-- dump date   	20140620_010314
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
351746000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
351746000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746000003	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746000004	Walker A motif; other site
351746000005	ATP binding site [chemical binding]; other site
351746000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
351746000007	Walker B motif; other site
351746000008	arginine finger; other site
351746000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
351746000010	DnaA box-binding interface [nucleotide binding]; other site
351746000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
351746000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
351746000013	putative DNA binding surface [nucleotide binding]; other site
351746000014	dimer interface [polypeptide binding]; other site
351746000015	beta-clamp/clamp loader binding surface; other site
351746000016	beta-clamp/translesion DNA polymerase binding surface; other site
351746000017	recombination protein F; Reviewed; Region: recF; PRK00064
351746000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746000019	Walker A/P-loop; other site
351746000020	ATP binding site [chemical binding]; other site
351746000021	Q-loop/lid; other site
351746000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746000023	ABC transporter signature motif; other site
351746000024	Walker B; other site
351746000025	D-loop; other site
351746000026	H-loop/switch region; other site
351746000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
351746000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000029	Mg2+ binding site [ion binding]; other site
351746000030	G-X-G motif; other site
351746000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
351746000032	anchoring element; other site
351746000033	dimer interface [polypeptide binding]; other site
351746000034	ATP binding site [chemical binding]; other site
351746000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
351746000036	active site
351746000037	putative metal-binding site [ion binding]; other site
351746000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
351746000039	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
351746000040	Integrase core domain; Region: rve; pfam00665
351746000041	Bacterial TniB protein; Region: TniB; pfam05621
351746000042	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746000043	TniQ; Region: TniQ; pfam06527
351746000044	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746000045	Predicted metal-binding protein [General function prediction only]; Region: COG3019
351746000046	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746000047	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
351746000048	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
351746000049	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
351746000050	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
351746000051	Multicopper oxidase; Region: Cu-oxidase; pfam00394
351746000052	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
351746000053	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
351746000054	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
351746000055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000056	active site
351746000057	phosphorylation site [posttranslational modification]
351746000058	intermolecular recognition site; other site
351746000059	dimerization interface [polypeptide binding]; other site
351746000060	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746000061	DNA binding site [nucleotide binding]
351746000062	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
351746000063	HAMP domain; Region: HAMP; pfam00672
351746000064	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746000065	dimer interface [polypeptide binding]; other site
351746000066	phosphorylation site [posttranslational modification]
351746000067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000068	ATP binding site [chemical binding]; other site
351746000069	Mg2+ binding site [ion binding]; other site
351746000070	G-X-G motif; other site
351746000071	Outer membrane efflux protein; Region: OEP; pfam02321
351746000072	Outer membrane efflux protein; Region: OEP; pfam02321
351746000073	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
351746000074	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746000075	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
351746000076	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
351746000077	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
351746000078	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
351746000079	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
351746000080	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
351746000081	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746000082	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746000083	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746000084	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746000085	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351746000086	metal-binding site [ion binding]
351746000087	YHS domain; Region: YHS; pfam04945
351746000088	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351746000089	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746000090	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746000091	motif II; other site
351746000092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
351746000093	ATP binding site [chemical binding]; other site
351746000094	Mg2+ binding site [ion binding]; other site
351746000095	G-X-G motif; other site
351746000096	putative metal dependent hydrolase; Provisional; Region: PRK11598
351746000097	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
351746000098	Sulfatase; Region: Sulfatase; pfam00884
351746000099	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
351746000100	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
351746000101	hypothetical protein; Provisional; Region: PRK09272
351746000102	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746000103	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
351746000104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000105	active site
351746000106	phosphorylation site [posttranslational modification]
351746000107	intermolecular recognition site; other site
351746000108	dimerization interface [polypeptide binding]; other site
351746000109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746000110	DNA binding site [nucleotide binding]
351746000111	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
351746000112	HAMP domain; Region: HAMP; pfam00672
351746000113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746000114	dimer interface [polypeptide binding]; other site
351746000115	phosphorylation site [posttranslational modification]
351746000116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000117	ATP binding site [chemical binding]; other site
351746000118	Mg2+ binding site [ion binding]; other site
351746000119	G-X-G motif; other site
351746000120	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
351746000121	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
351746000122	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
351746000123	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
351746000124	Ligand binding site; other site
351746000125	Putative Catalytic site; other site
351746000126	DXD motif; other site
351746000127	Membrane protein of unknown function; Region: DUF360; pfam04020
351746000128	Predicted membrane protein [Function unknown]; Region: COG2246
351746000129	GtrA-like protein; Region: GtrA; pfam04138
351746000130	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746000131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746000132	LysR substrate binding domain; Region: LysR_substrate; pfam03466
351746000133	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
351746000134	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
351746000135	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
351746000136	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746000137	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351746000138	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746000139	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
351746000140	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
351746000141	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746000142	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
351746000143	outer membrane porin, OprD family; Region: OprD; pfam03573
351746000144	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
351746000145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000146	active site
351746000147	phosphorylation site [posttranslational modification]
351746000148	intermolecular recognition site; other site
351746000149	dimerization interface [polypeptide binding]; other site
351746000150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746000151	DNA binding site [nucleotide binding]
351746000152	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
351746000153	PAS fold; Region: PAS_4; pfam08448
351746000154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746000155	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746000156	Walker A motif; other site
351746000157	ATP binding site [chemical binding]; other site
351746000158	Walker B motif; other site
351746000159	arginine finger; other site
351746000160	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746000161	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
351746000162	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
351746000163	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746000164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746000165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746000166	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746000167	dimerization interface [polypeptide binding]; other site
351746000168	choline dehydrogenase; Validated; Region: PRK02106
351746000169	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
351746000170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746000171	putative substrate translocation pore; other site
351746000172	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
351746000173	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
351746000174	putative acyl-acceptor binding pocket; other site
351746000175	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
351746000176	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746000177	active site
351746000178	motif I; other site
351746000179	motif II; other site
351746000180	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
351746000181	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
351746000182	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
351746000183	dimer interface [polypeptide binding]; other site
351746000184	motif 1; other site
351746000185	active site
351746000186	motif 2; other site
351746000187	motif 3; other site
351746000188	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
351746000189	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
351746000190	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
351746000191	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
351746000192	putative acyl-acceptor binding pocket; other site
351746000193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746000194	TPR motif; other site
351746000195	TPR repeat; Region: TPR_11; pfam13414
351746000196	binding surface
351746000197	K+ potassium transporter; Region: K_trans; cl15781
351746000198	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
351746000199	TrkA-N domain; Region: TrkA_N; pfam02254
351746000200	TrkA-C domain; Region: TrkA_C; pfam02080
351746000201	TrkA-N domain; Region: TrkA_N; pfam02254
351746000202	TrkA-C domain; Region: TrkA_C; pfam02080
351746000203	16S rRNA methyltransferase B; Provisional; Region: PRK10901
351746000204	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
351746000205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746000206	S-adenosylmethionine binding site [chemical binding]; other site
351746000207	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
351746000208	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
351746000209	putative active site [active]
351746000210	substrate binding site [chemical binding]; other site
351746000211	putative cosubstrate binding site; other site
351746000212	catalytic site [active]
351746000213	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
351746000214	substrate binding site [chemical binding]; other site
351746000215	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
351746000216	active site
351746000217	catalytic residues [active]
351746000218	metal binding site [ion binding]; metal-binding site
351746000219	DNA protecting protein DprA; Region: dprA; TIGR00732
351746000220	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
351746000221	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
351746000222	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746000223	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
351746000224	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
351746000225	NADP binding site [chemical binding]; other site
351746000226	dimer interface [polypeptide binding]; other site
351746000227	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
351746000228	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
351746000229	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
351746000230	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
351746000231	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
351746000232	shikimate binding site; other site
351746000233	NAD(P) binding site [chemical binding]; other site
351746000234	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
351746000235	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
351746000236	Sulfate transporter family; Region: Sulfate_transp; pfam00916
351746000237	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
351746000238	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
351746000239	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
351746000240	Sulfatase; Region: Sulfatase; cl17466
351746000241	choline-sulfatase; Region: chol_sulfatase; TIGR03417
351746000242	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
351746000243	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
351746000244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746000245	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746000246	dimerization interface [polypeptide binding]; other site
351746000247	substrate binding pocket [chemical binding]; other site
351746000248	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746000249	NADH(P)-binding; Region: NAD_binding_10; pfam13460
351746000250	NAD(P) binding site [chemical binding]; other site
351746000251	active site
351746000252	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
351746000253	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
351746000254	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
351746000255	substrate binding site [chemical binding]; other site
351746000256	active site
351746000257	catalytic residues [active]
351746000258	heterodimer interface [polypeptide binding]; other site
351746000259	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
351746000260	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
351746000261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746000262	catalytic residue [active]
351746000263	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746000264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746000265	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746000266	dimerization interface [polypeptide binding]; other site
351746000267	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
351746000268	Dodecin; Region: Dodecin; pfam07311
351746000269	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
351746000270	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
351746000271	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
351746000272	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
351746000273	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
351746000274	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
351746000275	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
351746000276	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
351746000277	Eukaryotic phosphomannomutase; Region: PMM; cl17107
351746000278	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746000279	motif II; other site
351746000280	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
351746000281	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
351746000282	trimer interface [polypeptide binding]; other site
351746000283	putative metal binding site [ion binding]; other site
351746000284	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
351746000285	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
351746000286	active site
351746000287	Zn binding site [ion binding]; other site
351746000288	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
351746000289	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
351746000290	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
351746000291	Zn binding site [ion binding]; other site
351746000292	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
351746000293	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746000294	FeS/SAM binding site; other site
351746000295	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
351746000296	active site clefts [active]
351746000297	zinc binding site [ion binding]; other site
351746000298	dimer interface [polypeptide binding]; other site
351746000299	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
351746000300	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
351746000301	Sulfate transporter family; Region: Sulfate_transp; pfam00916
351746000302	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
351746000303	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
351746000304	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
351746000305	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
351746000306	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746000307	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746000308	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
351746000309	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
351746000310	Subunit I/III interface [polypeptide binding]; other site
351746000311	D-pathway; other site
351746000312	Subunit I/VIIc interface [polypeptide binding]; other site
351746000313	Subunit I/IV interface [polypeptide binding]; other site
351746000314	Subunit I/II interface [polypeptide binding]; other site
351746000315	Low-spin heme (heme a) binding site [chemical binding]; other site
351746000316	Subunit I/VIIa interface [polypeptide binding]; other site
351746000317	Subunit I/VIa interface [polypeptide binding]; other site
351746000318	Dimer interface; other site
351746000319	Putative water exit pathway; other site
351746000320	Binuclear center (heme a3/CuB) [ion binding]; other site
351746000321	K-pathway; other site
351746000322	Subunit I/Vb interface [polypeptide binding]; other site
351746000323	Putative proton exit pathway; other site
351746000324	Subunit I/VIb interface; other site
351746000325	Subunit I/VIc interface [polypeptide binding]; other site
351746000326	Electron transfer pathway; other site
351746000327	Subunit I/VIIIb interface [polypeptide binding]; other site
351746000328	Subunit I/VIIb interface [polypeptide binding]; other site
351746000329	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
351746000330	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
351746000331	Subunit III/VIIa interface [polypeptide binding]; other site
351746000332	Phospholipid binding site [chemical binding]; other site
351746000333	Subunit I/III interface [polypeptide binding]; other site
351746000334	Subunit III/VIb interface [polypeptide binding]; other site
351746000335	Subunit III/VIa interface; other site
351746000336	Subunit III/Vb interface [polypeptide binding]; other site
351746000337	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
351746000338	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
351746000339	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
351746000340	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
351746000341	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
351746000342	UbiA prenyltransferase family; Region: UbiA; pfam01040
351746000343	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
351746000344	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746000345	Cu(I) binding site [ion binding]; other site
351746000346	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
351746000347	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
351746000348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000349	dimer interface [polypeptide binding]; other site
351746000350	conserved gate region; other site
351746000351	ABC-ATPase subunit interface; other site
351746000352	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
351746000353	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
351746000354	Walker A/P-loop; other site
351746000355	ATP binding site [chemical binding]; other site
351746000356	Q-loop/lid; other site
351746000357	ABC transporter signature motif; other site
351746000358	Walker B; other site
351746000359	D-loop; other site
351746000360	H-loop/switch region; other site
351746000361	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
351746000362	hydroperoxidase II; Provisional; Region: katE; PRK11249
351746000363	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
351746000364	tetramer interface [polypeptide binding]; other site
351746000365	heme binding pocket [chemical binding]; other site
351746000366	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
351746000367	domain interactions; other site
351746000368	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
351746000369	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351746000370	ABC-ATPase subunit  interface; other site
351746000371	dimer interface [polypeptide binding]; other site
351746000372	putative PBP binding regions; other site
351746000373	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
351746000374	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
351746000375	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
351746000376	metal binding site 2 [ion binding]; metal-binding site
351746000377	putative DNA binding helix; other site
351746000378	metal binding site 1 [ion binding]; metal-binding site
351746000379	dimer interface [polypeptide binding]; other site
351746000380	structural Zn2+ binding site [ion binding]; other site
351746000381	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
351746000382	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
351746000383	metal binding site [ion binding]; metal-binding site
351746000384	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
351746000385	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
351746000386	putative active site [active]
351746000387	putative substrate binding site [chemical binding]; other site
351746000388	ATP binding site [chemical binding]; other site
351746000389	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
351746000390	DNA polymerase I; Provisional; Region: PRK05755
351746000391	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
351746000392	active site
351746000393	metal binding site 1 [ion binding]; metal-binding site
351746000394	putative 5' ssDNA interaction site; other site
351746000395	metal binding site 3; metal-binding site
351746000396	metal binding site 2 [ion binding]; metal-binding site
351746000397	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
351746000398	putative DNA binding site [nucleotide binding]; other site
351746000399	putative metal binding site [ion binding]; other site
351746000400	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
351746000401	active site
351746000402	catalytic site [active]
351746000403	substrate binding site [chemical binding]; other site
351746000404	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
351746000405	active site
351746000406	DNA binding site [nucleotide binding]
351746000407	catalytic site [active]
351746000408	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
351746000409	G1 box; other site
351746000410	GTP/Mg2+ binding site [chemical binding]; other site
351746000411	Switch I region; other site
351746000412	G2 box; other site
351746000413	G3 box; other site
351746000414	Switch II region; other site
351746000415	G4 box; other site
351746000416	G5 box; other site
351746000417	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
351746000418	Cytochrome c553 [Energy production and conversion]; Region: COG2863
351746000419	Cytochrome c; Region: Cytochrom_C; cl11414
351746000420	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
351746000421	catalytic residues [active]
351746000422	hinge region; other site
351746000423	alpha helical domain; other site
351746000424	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
351746000425	putative catalytic site [active]
351746000426	putative metal binding site [ion binding]; other site
351746000427	putative phosphate binding site [ion binding]; other site
351746000428	putative catalytic site [active]
351746000429	putative phosphate binding site [ion binding]; other site
351746000430	putative metal binding site [ion binding]; other site
351746000431	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746000432	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746000433	metal binding site [ion binding]; metal-binding site
351746000434	active site
351746000435	I-site; other site
351746000436	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
351746000437	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
351746000438	amidase catalytic site [active]
351746000439	Zn binding residues [ion binding]; other site
351746000440	substrate binding site [chemical binding]; other site
351746000441	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
351746000442	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
351746000443	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
351746000444	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746000445	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746000446	dimerization interface [polypeptide binding]; other site
351746000447	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351746000448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746000449	dimer interface [polypeptide binding]; other site
351746000450	phosphorylation site [posttranslational modification]
351746000451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000452	ATP binding site [chemical binding]; other site
351746000453	Mg2+ binding site [ion binding]; other site
351746000454	G-X-G motif; other site
351746000455	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746000456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000457	active site
351746000458	phosphorylation site [posttranslational modification]
351746000459	intermolecular recognition site; other site
351746000460	dimerization interface [polypeptide binding]; other site
351746000461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746000462	Walker A motif; other site
351746000463	ATP binding site [chemical binding]; other site
351746000464	Walker B motif; other site
351746000465	arginine finger; other site
351746000466	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746000467	BON domain; Region: BON; pfam04972
351746000468	BON domain; Region: BON; pfam04972
351746000469	BON domain; Region: BON; pfam04972
351746000470	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
351746000471	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
351746000472	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746000473	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
351746000474	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
351746000475	Protein of unknown function (DUF330); Region: DUF330; cl01135
351746000476	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
351746000477	mce related protein; Region: MCE; pfam02470
351746000478	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
351746000479	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746000480	Walker A/P-loop; other site
351746000481	ATP binding site [chemical binding]; other site
351746000482	Q-loop/lid; other site
351746000483	ABC transporter signature motif; other site
351746000484	Walker B; other site
351746000485	D-loop; other site
351746000486	H-loop/switch region; other site
351746000487	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
351746000488	Permease; Region: Permease; pfam02405
351746000489	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
351746000490	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351746000491	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
351746000492	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351746000493	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
351746000494	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
351746000495	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
351746000496	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
351746000497	Citrate transporter; Region: CitMHS; pfam03600
351746000498	Uncharacterized conserved protein [Function unknown]; Region: COG3791
351746000499	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
351746000500	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
351746000501	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
351746000502	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
351746000503	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
351746000504	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
351746000505	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
351746000506	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
351746000507	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
351746000508	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
351746000509	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
351746000510	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
351746000511	ligand binding site [chemical binding]; other site
351746000512	homodimer interface [polypeptide binding]; other site
351746000513	NAD(P) binding site [chemical binding]; other site
351746000514	trimer interface B [polypeptide binding]; other site
351746000515	trimer interface A [polypeptide binding]; other site
351746000516	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746000517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746000518	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
351746000519	dimerization interface [polypeptide binding]; other site
351746000520	substrate binding pocket [chemical binding]; other site
351746000521	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
351746000522	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746000523	FAD binding site [chemical binding]; other site
351746000524	substrate binding pocket [chemical binding]; other site
351746000525	catalytic base [active]
351746000526	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
351746000527	CoA-transferase family III; Region: CoA_transf_3; pfam02515
351746000528	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746000529	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
351746000530	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746000531	N-terminal plug; other site
351746000532	ligand-binding site [chemical binding]; other site
351746000533	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746000534	FecR protein; Region: FecR; pfam04773
351746000535	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
351746000536	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746000537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746000538	DNA binding residues [nucleotide binding]
351746000539	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
351746000540	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746000541	DNA-binding site [nucleotide binding]; DNA binding site
351746000542	FCD domain; Region: FCD; pfam07729
351746000543	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
351746000544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746000545	dimerization interface [polypeptide binding]; other site
351746000546	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746000547	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746000548	metal binding site [ion binding]; metal-binding site
351746000549	active site
351746000550	I-site; other site
351746000551	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746000552	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
351746000553	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746000554	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746000555	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
351746000556	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
351746000557	putative active site [active]
351746000558	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746000559	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
351746000560	Walker A/P-loop; other site
351746000561	ATP binding site [chemical binding]; other site
351746000562	Q-loop/lid; other site
351746000563	ABC transporter signature motif; other site
351746000564	Walker B; other site
351746000565	D-loop; other site
351746000566	H-loop/switch region; other site
351746000567	Calx-beta domain; Region: Calx-beta; cl02522
351746000568	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
351746000569	metal ion-dependent adhesion site (MIDAS); other site
351746000570	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
351746000571	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
351746000572	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
351746000573	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
351746000574	NMT1-like family; Region: NMT1_2; pfam13379
351746000575	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
351746000576	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
351746000577	Walker A/P-loop; other site
351746000578	ATP binding site [chemical binding]; other site
351746000579	Q-loop/lid; other site
351746000580	ABC transporter signature motif; other site
351746000581	Walker B; other site
351746000582	D-loop; other site
351746000583	H-loop/switch region; other site
351746000584	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
351746000585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000586	putative PBP binding loops; other site
351746000587	ABC-ATPase subunit interface; other site
351746000588	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
351746000589	WYL domain; Region: WYL; pfam13280
351746000590	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
351746000591	Sel1-like repeats; Region: SEL1; smart00671
351746000592	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351746000593	MarR family; Region: MarR_2; cl17246
351746000594	Fusaric acid resistance protein family; Region: FUSC; pfam04632
351746000595	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
351746000596	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
351746000597	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
351746000598	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746000599	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746000600	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
351746000601	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746000602	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746000603	Cytochrome c; Region: Cytochrom_C; pfam00034
351746000604	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
351746000605	TIGR02647 family protein; Region: DNA
351746000606	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746000607	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
351746000608	C-terminal domain interface [polypeptide binding]; other site
351746000609	GSH binding site (G-site) [chemical binding]; other site
351746000610	dimer interface [polypeptide binding]; other site
351746000611	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
351746000612	putative N-terminal domain interface [polypeptide binding]; other site
351746000613	argininosuccinate lyase; Provisional; Region: PRK00855
351746000614	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
351746000615	active sites [active]
351746000616	tetramer interface [polypeptide binding]; other site
351746000617	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
351746000618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000619	active site
351746000620	phosphorylation site [posttranslational modification]
351746000621	intermolecular recognition site; other site
351746000622	dimerization interface [polypeptide binding]; other site
351746000623	LytTr DNA-binding domain; Region: LytTR; pfam04397
351746000624	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
351746000625	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
351746000626	domain interfaces; other site
351746000627	active site
351746000628	uroporphyrinogen-III synthase; Validated; Region: PRK05752
351746000629	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
351746000630	active site
351746000631	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
351746000632	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
351746000633	HemY protein N-terminus; Region: HemY_N; pfam07219
351746000634	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
351746000635	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
351746000636	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
351746000637	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
351746000638	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746000639	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
351746000640	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
351746000641	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746000642	Walker A/P-loop; other site
351746000643	ATP binding site [chemical binding]; other site
351746000644	Q-loop/lid; other site
351746000645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746000646	ABC transporter signature motif; other site
351746000647	Walker B; other site
351746000648	D-loop; other site
351746000649	ABC transporter; Region: ABC_tran_2; pfam12848
351746000650	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746000651	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
351746000652	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746000653	LysE type translocator; Region: LysE; cl00565
351746000654	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
351746000655	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
351746000656	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
351746000657	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
351746000658	dimer interface [polypeptide binding]; other site
351746000659	active site residues [active]
351746000660	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
351746000661	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
351746000662	putative deacylase active site [active]
351746000663	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
351746000664	FOG: CBS domain [General function prediction only]; Region: COG0517
351746000665	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
351746000666	hypothetical protein; Provisional; Region: PRK06156
351746000667	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
351746000668	active site
351746000669	metal binding site [ion binding]; metal-binding site
351746000670	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
351746000671	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
351746000672	tetramerization interface [polypeptide binding]; other site
351746000673	NAD(P) binding site [chemical binding]; other site
351746000674	catalytic residues [active]
351746000675	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
351746000676	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746000677	inhibitor-cofactor binding pocket; inhibition site
351746000678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746000679	catalytic residue [active]
351746000680	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746000681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000682	active site
351746000683	phosphorylation site [posttranslational modification]
351746000684	intermolecular recognition site; other site
351746000685	dimerization interface [polypeptide binding]; other site
351746000686	HDOD domain; Region: HDOD; pfam08668
351746000687	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746000688	PAS fold; Region: PAS_3; pfam08447
351746000689	putative active site [active]
351746000690	heme pocket [chemical binding]; other site
351746000691	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746000692	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746000693	metal binding site [ion binding]; metal-binding site
351746000694	active site
351746000695	I-site; other site
351746000696	Fatty acid desaturase; Region: FA_desaturase; pfam00487
351746000697	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
351746000698	Di-iron ligands [ion binding]; other site
351746000699	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
351746000700	Transposase; Region: DDE_Tnp_ISL3; pfam01610
351746000701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746000702	PAS domain; Region: PAS_9; pfam13426
351746000703	putative active site [active]
351746000704	heme pocket [chemical binding]; other site
351746000705	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746000706	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746000707	metal binding site [ion binding]; metal-binding site
351746000708	active site
351746000709	I-site; other site
351746000710	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746000711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000712	dimer interface [polypeptide binding]; other site
351746000713	conserved gate region; other site
351746000714	putative PBP binding loops; other site
351746000715	ABC-ATPase subunit interface; other site
351746000716	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
351746000717	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
351746000718	Walker A/P-loop; other site
351746000719	ATP binding site [chemical binding]; other site
351746000720	Q-loop/lid; other site
351746000721	ABC transporter signature motif; other site
351746000722	Walker B; other site
351746000723	D-loop; other site
351746000724	H-loop/switch region; other site
351746000725	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
351746000726	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
351746000727	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
351746000728	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
351746000729	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
351746000730	active site
351746000731	non-prolyl cis peptide bond; other site
351746000732	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
351746000733	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746000734	active site
351746000735	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
351746000736	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746000737	active site
351746000738	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
351746000739	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746000740	Walker A/P-loop; other site
351746000741	ATP binding site [chemical binding]; other site
351746000742	Q-loop/lid; other site
351746000743	ABC transporter signature motif; other site
351746000744	Walker B; other site
351746000745	D-loop; other site
351746000746	H-loop/switch region; other site
351746000747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000748	dimer interface [polypeptide binding]; other site
351746000749	conserved gate region; other site
351746000750	putative PBP binding loops; other site
351746000751	ABC-ATPase subunit interface; other site
351746000752	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746000753	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746000754	substrate binding pocket [chemical binding]; other site
351746000755	membrane-bound complex binding site; other site
351746000756	hinge residues; other site
351746000757	serine O-acetyltransferase; Region: cysE; TIGR01172
351746000758	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
351746000759	trimer interface [polypeptide binding]; other site
351746000760	active site
351746000761	substrate binding site [chemical binding]; other site
351746000762	CoA binding site [chemical binding]; other site
351746000763	BCCT family transporter; Region: BCCT; cl00569
351746000764	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
351746000765	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
351746000766	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
351746000767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000768	dimer interface [polypeptide binding]; other site
351746000769	conserved gate region; other site
351746000770	putative PBP binding loops; other site
351746000771	ABC-ATPase subunit interface; other site
351746000772	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
351746000773	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
351746000774	Walker A/P-loop; other site
351746000775	ATP binding site [chemical binding]; other site
351746000776	Q-loop/lid; other site
351746000777	ABC transporter signature motif; other site
351746000778	Walker B; other site
351746000779	D-loop; other site
351746000780	H-loop/switch region; other site
351746000781	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
351746000782	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746000783	substrate binding pocket [chemical binding]; other site
351746000784	membrane-bound complex binding site; other site
351746000785	hinge residues; other site
351746000786	outer membrane porin, OprD family; Region: OprD; pfam03573
351746000787	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
351746000788	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
351746000789	dimer interface [polypeptide binding]; other site
351746000790	decamer (pentamer of dimers) interface [polypeptide binding]; other site
351746000791	catalytic triad [active]
351746000792	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
351746000793	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746000794	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
351746000795	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746000796	substrate binding pocket [chemical binding]; other site
351746000797	membrane-bound complex binding site; other site
351746000798	hinge residues; other site
351746000799	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
351746000800	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
351746000801	active site
351746000802	dimer interface [polypeptide binding]; other site
351746000803	non-prolyl cis peptide bond; other site
351746000804	insertion regions; other site
351746000805	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
351746000806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000807	dimer interface [polypeptide binding]; other site
351746000808	conserved gate region; other site
351746000809	putative PBP binding loops; other site
351746000810	ABC-ATPase subunit interface; other site
351746000811	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
351746000812	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
351746000813	Walker A/P-loop; other site
351746000814	ATP binding site [chemical binding]; other site
351746000815	Q-loop/lid; other site
351746000816	ABC transporter signature motif; other site
351746000817	Walker B; other site
351746000818	D-loop; other site
351746000819	H-loop/switch region; other site
351746000820	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
351746000821	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746000822	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746000823	glutamate--cysteine ligase; Provisional; Region: PRK02107
351746000824	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
351746000825	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
351746000826	CoenzymeA binding site [chemical binding]; other site
351746000827	subunit interaction site [polypeptide binding]; other site
351746000828	PHB binding site; other site
351746000829	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
351746000830	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
351746000831	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
351746000832	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
351746000833	RNA binding site [nucleotide binding]; other site
351746000834	osmolarity response regulator; Provisional; Region: ompR; PRK09468
351746000835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000836	active site
351746000837	phosphorylation site [posttranslational modification]
351746000838	intermolecular recognition site; other site
351746000839	dimerization interface [polypeptide binding]; other site
351746000840	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746000841	DNA binding site [nucleotide binding]
351746000842	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
351746000843	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746000844	dimerization interface [polypeptide binding]; other site
351746000845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000846	ATP binding site [chemical binding]; other site
351746000847	Mg2+ binding site [ion binding]; other site
351746000848	G-X-G motif; other site
351746000849	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
351746000850	RimK-like ATP-grasp domain; Region: RimK; pfam08443
351746000851	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
351746000852	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746000853	RNA binding surface [nucleotide binding]; other site
351746000854	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
351746000855	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
351746000856	active site
351746000857	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
351746000858	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
351746000859	dimerization interface [polypeptide binding]; other site
351746000860	domain crossover interface; other site
351746000861	redox-dependent activation switch; other site
351746000862	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
351746000863	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
351746000864	active site
351746000865	substrate-binding site [chemical binding]; other site
351746000866	metal-binding site [ion binding]
351746000867	ATP binding site [chemical binding]; other site
351746000868	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
351746000869	active site
351746000870	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
351746000871	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
351746000872	putative molybdopterin cofactor binding site [chemical binding]; other site
351746000873	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
351746000874	putative molybdopterin cofactor binding site; other site
351746000875	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
351746000876	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
351746000877	BON domain; Region: BON; pfam04972
351746000878	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351746000879	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
351746000880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746000881	motif II; other site
351746000882	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
351746000883	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
351746000884	dimer interface [polypeptide binding]; other site
351746000885	ADP-ribose binding site [chemical binding]; other site
351746000886	active site
351746000887	nudix motif; other site
351746000888	metal binding site [ion binding]; metal-binding site
351746000889	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
351746000890	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
351746000891	active site
351746000892	thioesterase domain, putative; Region: yiiD_Cterm; TIGR02447
351746000893	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746000894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000895	active site
351746000896	phosphorylation site [posttranslational modification]
351746000897	intermolecular recognition site; other site
351746000898	dimerization interface [polypeptide binding]; other site
351746000899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746000900	Walker A motif; other site
351746000901	ATP binding site [chemical binding]; other site
351746000902	Walker B motif; other site
351746000903	arginine finger; other site
351746000904	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746000905	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
351746000906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746000907	dimer interface [polypeptide binding]; other site
351746000908	phosphorylation site [posttranslational modification]
351746000909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000910	ATP binding site [chemical binding]; other site
351746000911	G-X-G motif; other site
351746000912	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
351746000913	agmatine deiminase; Provisional; Region: PRK13551
351746000914	agmatine deiminase; Region: agmatine_aguA; TIGR03380
351746000915	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746000916	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746000917	N-terminal plug; other site
351746000918	ligand-binding site [chemical binding]; other site
351746000919	outer membrane porin, OprD family; Region: OprD; pfam03573
351746000920	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
351746000921	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
351746000922	active site
351746000923	FMN binding site [chemical binding]; other site
351746000924	substrate binding site [chemical binding]; other site
351746000925	3Fe-4S cluster binding site [ion binding]; other site
351746000926	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
351746000927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746000928	ATP binding site [chemical binding]; other site
351746000929	Mg2+ binding site [ion binding]; other site
351746000930	G-X-G motif; other site
351746000931	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746000932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746000933	active site
351746000934	phosphorylation site [posttranslational modification]
351746000935	intermolecular recognition site; other site
351746000936	dimerization interface [polypeptide binding]; other site
351746000937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746000938	DNA binding site [nucleotide binding]
351746000939	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
351746000940	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746000941	N-terminal plug; other site
351746000942	ligand-binding site [chemical binding]; other site
351746000943	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
351746000944	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
351746000945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746000946	non-specific DNA binding site [nucleotide binding]; other site
351746000947	salt bridge; other site
351746000948	sequence-specific DNA binding site [nucleotide binding]; other site
351746000949	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
351746000950	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746000951	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746000952	non-specific DNA binding site [nucleotide binding]; other site
351746000953	sequence-specific DNA binding site [nucleotide binding]; other site
351746000954	salt bridge; other site
351746000955	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746000956	Methyltransferase domain; Region: Methyltransf_32; pfam13679
351746000957	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746000958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000959	dimer interface [polypeptide binding]; other site
351746000960	conserved gate region; other site
351746000961	putative PBP binding loops; other site
351746000962	ABC-ATPase subunit interface; other site
351746000963	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746000964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746000965	dimer interface [polypeptide binding]; other site
351746000966	conserved gate region; other site
351746000967	putative PBP binding loops; other site
351746000968	ABC-ATPase subunit interface; other site
351746000969	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746000970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746000971	substrate binding pocket [chemical binding]; other site
351746000972	membrane-bound complex binding site; other site
351746000973	hinge residues; other site
351746000974	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
351746000975	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746000976	Walker A/P-loop; other site
351746000977	ATP binding site [chemical binding]; other site
351746000978	Q-loop/lid; other site
351746000979	ABC transporter signature motif; other site
351746000980	Walker B; other site
351746000981	D-loop; other site
351746000982	H-loop/switch region; other site
351746000983	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
351746000984	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
351746000985	oxidative damage protection protein; Provisional; Region: PRK05408
351746000986	adenine DNA glycosylase; Provisional; Region: PRK10880
351746000987	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
351746000988	minor groove reading motif; other site
351746000989	helix-hairpin-helix signature motif; other site
351746000990	substrate binding pocket [chemical binding]; other site
351746000991	active site
351746000992	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
351746000993	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
351746000994	DNA binding and oxoG recognition site [nucleotide binding]
351746000995	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
351746000996	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
351746000997	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
351746000998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746000999	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
351746001000	putative active site pocket [active]
351746001001	4-fold oligomerization interface [polypeptide binding]; other site
351746001002	metal binding residues [ion binding]; metal-binding site
351746001003	3-fold/trimer interface [polypeptide binding]; other site
351746001004	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
351746001005	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
351746001006	putative active site [active]
351746001007	oxyanion strand; other site
351746001008	catalytic triad [active]
351746001009	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
351746001010	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
351746001011	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
351746001012	catalytic residues [active]
351746001013	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
351746001014	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
351746001015	substrate binding site [chemical binding]; other site
351746001016	glutamase interaction surface [polypeptide binding]; other site
351746001017	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
351746001018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746001019	Walker A/P-loop; other site
351746001020	ATP binding site [chemical binding]; other site
351746001021	Q-loop/lid; other site
351746001022	ABC transporter signature motif; other site
351746001023	Walker B; other site
351746001024	D-loop; other site
351746001025	H-loop/switch region; other site
351746001026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746001027	dimer interface [polypeptide binding]; other site
351746001028	conserved gate region; other site
351746001029	putative PBP binding loops; other site
351746001030	ABC-ATPase subunit interface; other site
351746001031	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
351746001032	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
351746001033	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
351746001034	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
351746001035	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
351746001036	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746001037	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
351746001038	conserved cys residue [active]
351746001039	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746001040	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
351746001041	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
351746001042	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
351746001043	putative sugar binding sites [chemical binding]; other site
351746001044	Q-X-W motif; other site
351746001045	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
351746001046	active site
351746001047	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
351746001048	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
351746001049	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746001050	Uncharacterized conserved protein [Function unknown]; Region: COG3246
351746001051	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
351746001052	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
351746001053	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746001054	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
351746001055	conserved cys residue [active]
351746001056	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746001057	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
351746001058	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
351746001059	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
351746001060	active site
351746001061	V4R domain; Region: V4R; cl15268
351746001062	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
351746001063	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
351746001064	putative active site [active]
351746001065	putative FMN binding site [chemical binding]; other site
351746001066	putative substrate binding site [chemical binding]; other site
351746001067	putative catalytic residue [active]
351746001068	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
351746001069	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
351746001070	Cysteine-rich domain; Region: CCG; pfam02754
351746001071	Cysteine-rich domain; Region: CCG; pfam02754
351746001072	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
351746001073	Ligand Binding Site [chemical binding]; other site
351746001074	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
351746001075	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
351746001076	Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086
351746001077	Ligand Binding Site [chemical binding]; other site
351746001078	Electron transfer flavoprotein domain; Region: ETF; pfam01012
351746001079	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746001080	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
351746001081	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
351746001082	[2Fe-2S] cluster binding site [ion binding]; other site
351746001083	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
351746001084	putative alpha subunit interface [polypeptide binding]; other site
351746001085	putative active site [active]
351746001086	putative substrate binding site [chemical binding]; other site
351746001087	Fe binding site [ion binding]; other site
351746001088	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
351746001089	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
351746001090	FAD binding pocket [chemical binding]; other site
351746001091	FAD binding motif [chemical binding]; other site
351746001092	phosphate binding motif [ion binding]; other site
351746001093	beta-alpha-beta structure motif; other site
351746001094	NAD binding pocket [chemical binding]; other site
351746001095	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746001096	catalytic loop [active]
351746001097	iron binding site [ion binding]; other site
351746001098	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746001099	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
351746001100	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
351746001101	HAMP domain; Region: HAMP; pfam00672
351746001102	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746001103	dimer interface [polypeptide binding]; other site
351746001104	putative CheW interface [polypeptide binding]; other site
351746001105	Cell division protein ZapA; Region: ZapA; pfam05164
351746001106	Cache domain; Region: Cache_1; pfam02743
351746001107	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746001108	dimerization interface [polypeptide binding]; other site
351746001109	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746001110	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746001111	dimer interface [polypeptide binding]; other site
351746001112	putative CheW interface [polypeptide binding]; other site
351746001113	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
351746001114	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
351746001115	tetramer interface [polypeptide binding]; other site
351746001116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746001117	catalytic residue [active]
351746001118	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
351746001119	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
351746001120	dimer interface [polypeptide binding]; other site
351746001121	active site
351746001122	glycine-pyridoxal phosphate binding site [chemical binding]; other site
351746001123	folate binding site [chemical binding]; other site
351746001124	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
351746001125	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746001126	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
351746001127	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
351746001128	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
351746001129	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
351746001130	Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268
351746001131	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
351746001132	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
351746001133	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
351746001134	putative active site [active]
351746001135	putative substrate binding site [chemical binding]; other site
351746001136	putative cosubstrate binding site; other site
351746001137	catalytic site [active]
351746001138	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
351746001139	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
351746001140	NAD binding site [chemical binding]; other site
351746001141	catalytic Zn binding site [ion binding]; other site
351746001142	structural Zn binding site [ion binding]; other site
351746001143	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746001144	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
351746001145	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746001146	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
351746001147	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
351746001148	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
351746001149	putative acyl-acceptor binding pocket; other site
351746001150	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
351746001151	DNA-binding response regulator CreB; Provisional; Region: PRK11083
351746001152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746001153	active site
351746001154	phosphorylation site [posttranslational modification]
351746001155	intermolecular recognition site; other site
351746001156	dimerization interface [polypeptide binding]; other site
351746001157	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746001158	DNA binding site [nucleotide binding]
351746001159	sensory histidine kinase CreC; Provisional; Region: PRK11100
351746001160	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746001161	dimerization interface [polypeptide binding]; other site
351746001162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746001163	dimer interface [polypeptide binding]; other site
351746001164	phosphorylation site [posttranslational modification]
351746001165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746001166	ATP binding site [chemical binding]; other site
351746001167	G-X-G motif; other site
351746001168	inner membrane protein; Provisional; Region: PRK11715
351746001169	putative glutathione S-transferase; Provisional; Region: PRK10357
351746001170	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
351746001171	putative C-terminal domain interface [polypeptide binding]; other site
351746001172	putative GSH binding site (G-site) [chemical binding]; other site
351746001173	putative dimer interface [polypeptide binding]; other site
351746001174	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
351746001175	dimer interface [polypeptide binding]; other site
351746001176	N-terminal domain interface [polypeptide binding]; other site
351746001177	putative substrate binding pocket (H-site) [chemical binding]; other site
351746001178	methionine sulfoxide reductase A; Provisional; Region: PRK00058
351746001179	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
351746001180	GAF domain; Region: GAF; pfam01590
351746001181	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001182	PAS domain; Region: PAS_9; pfam13426
351746001183	putative active site [active]
351746001184	heme pocket [chemical binding]; other site
351746001185	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746001186	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746001187	metal binding site [ion binding]; metal-binding site
351746001188	active site
351746001189	I-site; other site
351746001190	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746001191	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
351746001192	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351746001193	E3 interaction surface; other site
351746001194	lipoyl attachment site [posttranslational modification]; other site
351746001195	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351746001196	E3 interaction surface; other site
351746001197	lipoyl attachment site [posttranslational modification]; other site
351746001198	e3 binding domain; Region: E3_binding; pfam02817
351746001199	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
351746001200	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
351746001201	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
351746001202	dimer interface [polypeptide binding]; other site
351746001203	TPP-binding site [chemical binding]; other site
351746001204	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
351746001205	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
351746001206	metal binding triad; other site
351746001207	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
351746001208	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
351746001209	metal binding triad; other site
351746001210	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
351746001211	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
351746001212	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
351746001213	putative active site [active]
351746001214	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
351746001215	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
351746001216	putative active site [active]
351746001217	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746001218	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
351746001219	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
351746001220	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
351746001221	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
351746001222	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
351746001223	active site
351746001224	ATP binding site [chemical binding]; other site
351746001225	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
351746001226	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
351746001227	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
351746001228	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746001229	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
351746001230	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746001231	N-terminal plug; other site
351746001232	ligand-binding site [chemical binding]; other site
351746001233	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746001234	FecR protein; Region: FecR; pfam04773
351746001235	RNA polymerase sigma factor; Reviewed; Region: PRK12523
351746001236	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746001237	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746001238	DNA binding residues [nucleotide binding]
351746001239	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
351746001240	active site
351746001241	catalytic site [active]
351746001242	substrate binding site [chemical binding]; other site
351746001243	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
351746001244	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351746001245	ligand binding site [chemical binding]; other site
351746001246	flexible hinge region; other site
351746001247	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
351746001248	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
351746001249	metal binding triad; other site
351746001250	Response regulator receiver domain; Region: Response_reg; pfam00072
351746001251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746001252	active site
351746001253	phosphorylation site [posttranslational modification]
351746001254	intermolecular recognition site; other site
351746001255	dimerization interface [polypeptide binding]; other site
351746001256	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
351746001257	active site
351746001258	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
351746001259	ACT domain; Region: ACT_6; pfam13740
351746001260	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
351746001261	Predicted permeases [General function prediction only]; Region: RarD; COG2962
351746001262	serine/threonine protein kinase; Provisional; Region: PRK11768
351746001263	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
351746001264	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
351746001265	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
351746001266	TOBE domain; Region: TOBE; cl01440
351746001267	DNA utilization protein GntX; Provisional; Region: PRK11595
351746001268	biotin synthase; Provisional; Region: PRK15108
351746001269	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746001270	FeS/SAM binding site; other site
351746001271	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
351746001272	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
351746001273	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
351746001274	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746001275	catalytic residue [active]
351746001276	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
351746001277	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
351746001278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746001279	S-adenosylmethionine binding site [chemical binding]; other site
351746001280	AAA domain; Region: AAA_26; pfam13500
351746001281	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
351746001282	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746001283	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
351746001284	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746001285	active site
351746001286	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746001287	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746001288	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746001289	metal binding site [ion binding]; metal-binding site
351746001290	active site
351746001291	I-site; other site
351746001292	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746001293	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
351746001294	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746001295	active site
351746001296	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746001297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746001298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746001299	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746001300	dimerization interface [polypeptide binding]; other site
351746001301	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
351746001302	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746001303	inhibitor-cofactor binding pocket; inhibition site
351746001304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746001305	catalytic residue [active]
351746001306	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
351746001307	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
351746001308	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746001309	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
351746001310	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746001311	FeS/SAM binding site; other site
351746001312	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
351746001313	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
351746001314	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
351746001315	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
351746001316	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
351746001317	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
351746001318	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
351746001319	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351746001320	Predicted amidohydrolase [General function prediction only]; Region: COG0388
351746001321	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
351746001322	putative active site [active]
351746001323	catalytic triad [active]
351746001324	putative dimer interface [polypeptide binding]; other site
351746001325	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
351746001326	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746001327	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
351746001328	putative DNA binding site [nucleotide binding]; other site
351746001329	putative Zn2+ binding site [ion binding]; other site
351746001330	AsnC family; Region: AsnC_trans_reg; pfam01037
351746001331	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
351746001332	trimer interface [polypeptide binding]; other site
351746001333	active site
351746001334	substrate binding site [chemical binding]; other site
351746001335	CoA binding site [chemical binding]; other site
351746001336	Domain of unknown function (DUF955); Region: DUF955; pfam06114
351746001337	Beta protein; Region: Beta_protein; pfam14350
351746001338	HTH-like domain; Region: HTH_21; pfam13276
351746001339	Integrase core domain; Region: rve; pfam00665
351746001340	Integrase core domain; Region: rve_2; pfam13333
351746001341	Transposase; Region: HTH_Tnp_1; pfam01527
351746001342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
351746001343	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746001344	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746001345	substrate binding pocket [chemical binding]; other site
351746001346	membrane-bound complex binding site; other site
351746001347	hinge residues; other site
351746001348	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
351746001349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001350	putative active site [active]
351746001351	heme pocket [chemical binding]; other site
351746001352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001353	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
351746001354	putative active site [active]
351746001355	heme pocket [chemical binding]; other site
351746001356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001357	putative active site [active]
351746001358	heme pocket [chemical binding]; other site
351746001359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001360	putative active site [active]
351746001361	heme pocket [chemical binding]; other site
351746001362	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746001363	metal binding site [ion binding]; metal-binding site
351746001364	active site
351746001365	I-site; other site
351746001366	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746001367	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
351746001368	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
351746001369	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
351746001370	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
351746001371	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746001372	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351746001373	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746001374	DNA binding residues [nucleotide binding]
351746001375	DNA primase, catalytic core; Region: dnaG; TIGR01391
351746001376	CHC2 zinc finger; Region: zf-CHC2; pfam01807
351746001377	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
351746001378	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
351746001379	active site
351746001380	metal binding site [ion binding]; metal-binding site
351746001381	interdomain interaction site; other site
351746001382	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
351746001383	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
351746001384	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
351746001385	UGMP family protein; Validated; Region: PRK09604
351746001386	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
351746001387	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
351746001388	Dihydroneopterin aldolase; Region: FolB; smart00905
351746001389	active site
351746001390	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
351746001391	catalytic center binding site [active]
351746001392	ATP binding site [chemical binding]; other site
351746001393	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
351746001394	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
351746001395	active site
351746001396	NTP binding site [chemical binding]; other site
351746001397	metal binding triad [ion binding]; metal-binding site
351746001398	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
351746001399	SpoVR family protein; Provisional; Region: PRK11767
351746001400	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
351746001401	hypothetical protein; Provisional; Region: PRK05325
351746001402	PrkA family serine protein kinase; Provisional; Region: PRK15455
351746001403	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
351746001404	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
351746001405	active site residue [active]
351746001406	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
351746001407	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
351746001408	active site
351746001409	metal binding site [ion binding]; metal-binding site
351746001410	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
351746001411	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
351746001412	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
351746001413	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
351746001414	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
351746001415	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
351746001416	SurA N-terminal domain; Region: SurA_N; pfam09312
351746001417	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
351746001418	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
351746001419	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
351746001420	OstA-like protein; Region: OstA; cl00844
351746001421	Organic solvent tolerance protein; Region: OstA_C; pfam04453
351746001422	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
351746001423	Phosphotransferase enzyme family; Region: APH; pfam01636
351746001424	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
351746001425	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
351746001426	Substrate binding site; other site
351746001427	metal-binding site
351746001428	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
351746001429	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
351746001430	putative metal binding site [ion binding]; other site
351746001431	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
351746001432	HSP70 interaction site [polypeptide binding]; other site
351746001433	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
351746001434	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746001435	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746001436	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746001437	substrate binding pocket [chemical binding]; other site
351746001438	membrane-bound complex binding site; other site
351746001439	hinge residues; other site
351746001440	PAS domain; Region: PAS_9; pfam13426
351746001441	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001442	putative active site [active]
351746001443	heme pocket [chemical binding]; other site
351746001444	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746001445	PAS fold; Region: PAS_3; pfam08447
351746001446	putative active site [active]
351746001447	heme pocket [chemical binding]; other site
351746001448	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
351746001449	Histidine kinase; Region: HisKA_3; pfam07730
351746001450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746001451	ATP binding site [chemical binding]; other site
351746001452	Mg2+ binding site [ion binding]; other site
351746001453	G-X-G motif; other site
351746001454	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746001455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746001456	active site
351746001457	phosphorylation site [posttranslational modification]
351746001458	intermolecular recognition site; other site
351746001459	dimerization interface [polypeptide binding]; other site
351746001460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746001461	DNA binding residues [nucleotide binding]
351746001462	dimerization interface [polypeptide binding]; other site
351746001463	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
351746001464	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
351746001465	Walker A/P-loop; other site
351746001466	ATP binding site [chemical binding]; other site
351746001467	Q-loop/lid; other site
351746001468	ABC transporter signature motif; other site
351746001469	Walker B; other site
351746001470	D-loop; other site
351746001471	H-loop/switch region; other site
351746001472	TOBE domain; Region: TOBE_2; pfam08402
351746001473	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
351746001474	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746001475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746001476	dimer interface [polypeptide binding]; other site
351746001477	conserved gate region; other site
351746001478	putative PBP binding loops; other site
351746001479	ABC-ATPase subunit interface; other site
351746001480	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746001481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746001482	dimer interface [polypeptide binding]; other site
351746001483	conserved gate region; other site
351746001484	putative PBP binding loops; other site
351746001485	ABC-ATPase subunit interface; other site
351746001486	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
351746001487	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
351746001488	substrate binding site [chemical binding]; other site
351746001489	hexamer interface [polypeptide binding]; other site
351746001490	metal binding site [ion binding]; metal-binding site
351746001491	phosphoglycolate phosphatase; Provisional; Region: PRK13223
351746001492	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351746001493	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746001494	motif II; other site
351746001495	anthranilate synthase component I; Provisional; Region: PRK13565
351746001496	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
351746001497	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
351746001498	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
351746001499	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
351746001500	active site
351746001501	catalytic triad [active]
351746001502	oxyanion hole [active]
351746001503	Autotransporter beta-domain; Region: Autotransporter; pfam03797
351746001504	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
351746001505	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
351746001506	glutamine binding [chemical binding]; other site
351746001507	catalytic triad [active]
351746001508	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
351746001509	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
351746001510	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
351746001511	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
351746001512	active site
351746001513	ribulose/triose binding site [chemical binding]; other site
351746001514	phosphate binding site [ion binding]; other site
351746001515	substrate (anthranilate) binding pocket [chemical binding]; other site
351746001516	product (indole) binding pocket [chemical binding]; other site
351746001517	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
351746001518	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
351746001519	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351746001520	ligand binding site [chemical binding]; other site
351746001521	flexible hinge region; other site
351746001522	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
351746001523	putative switch regulator; other site
351746001524	non-specific DNA interactions [nucleotide binding]; other site
351746001525	DNA binding site [nucleotide binding]
351746001526	sequence specific DNA binding site [nucleotide binding]; other site
351746001527	putative cAMP binding site [chemical binding]; other site
351746001528	OsmC-like protein; Region: OsmC; cl00767
351746001529	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
351746001530	diiron binding motif [ion binding]; other site
351746001531	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
351746001532	nucleotide binding site/active site [active]
351746001533	HIT family signature motif; other site
351746001534	catalytic residue [active]
351746001535	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
351746001536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746001537	NAD(P) binding site [chemical binding]; other site
351746001538	active site
351746001539	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
351746001540	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
351746001541	FMN binding site [chemical binding]; other site
351746001542	substrate binding site [chemical binding]; other site
351746001543	putative catalytic residue [active]
351746001544	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
351746001545	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
351746001546	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351746001547	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
351746001548	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
351746001549	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
351746001550	Peptidase family M23; Region: Peptidase_M23; pfam01551
351746001551	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
351746001552	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
351746001553	active site
351746001554	HIGH motif; other site
351746001555	dimer interface [polypeptide binding]; other site
351746001556	KMSKS motif; other site
351746001557	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
351746001558	Biotin operon repressor [Transcription]; Region: BirA; COG1654
351746001559	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
351746001560	pantothenate kinase; Reviewed; Region: PRK13322
351746001561	elongation factor Tu; Reviewed; Region: PRK00049
351746001562	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
351746001563	G1 box; other site
351746001564	GEF interaction site [polypeptide binding]; other site
351746001565	GTP/Mg2+ binding site [chemical binding]; other site
351746001566	Switch I region; other site
351746001567	G2 box; other site
351746001568	G3 box; other site
351746001569	Switch II region; other site
351746001570	G4 box; other site
351746001571	G5 box; other site
351746001572	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
351746001573	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
351746001574	Antibiotic Binding Site [chemical binding]; other site
351746001575	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
351746001576	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
351746001577	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
351746001578	putative homodimer interface [polypeptide binding]; other site
351746001579	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
351746001580	heterodimer interface [polypeptide binding]; other site
351746001581	homodimer interface [polypeptide binding]; other site
351746001582	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
351746001583	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
351746001584	23S rRNA interface [nucleotide binding]; other site
351746001585	L7/L12 interface [polypeptide binding]; other site
351746001586	putative thiostrepton binding site; other site
351746001587	L25 interface [polypeptide binding]; other site
351746001588	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
351746001589	mRNA/rRNA interface [nucleotide binding]; other site
351746001590	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
351746001591	23S rRNA interface [nucleotide binding]; other site
351746001592	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
351746001593	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
351746001594	core dimer interface [polypeptide binding]; other site
351746001595	peripheral dimer interface [polypeptide binding]; other site
351746001596	L10 interface [polypeptide binding]; other site
351746001597	L11 interface [polypeptide binding]; other site
351746001598	putative EF-Tu interaction site [polypeptide binding]; other site
351746001599	putative EF-G interaction site [polypeptide binding]; other site
351746001600	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
351746001601	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
351746001602	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
351746001603	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
351746001604	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
351746001605	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
351746001606	RPB3 interaction site [polypeptide binding]; other site
351746001607	RPB1 interaction site [polypeptide binding]; other site
351746001608	RPB11 interaction site [polypeptide binding]; other site
351746001609	RPB10 interaction site [polypeptide binding]; other site
351746001610	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
351746001611	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
351746001612	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
351746001613	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
351746001614	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
351746001615	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
351746001616	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
351746001617	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
351746001618	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
351746001619	DNA binding site [nucleotide binding]
351746001620	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
351746001621	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
351746001622	S17 interaction site [polypeptide binding]; other site
351746001623	S8 interaction site; other site
351746001624	16S rRNA interaction site [nucleotide binding]; other site
351746001625	streptomycin interaction site [chemical binding]; other site
351746001626	23S rRNA interaction site [nucleotide binding]; other site
351746001627	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
351746001628	30S ribosomal protein S7; Validated; Region: PRK05302
351746001629	elongation factor G; Reviewed; Region: PRK00007
351746001630	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
351746001631	G1 box; other site
351746001632	putative GEF interaction site [polypeptide binding]; other site
351746001633	GTP/Mg2+ binding site [chemical binding]; other site
351746001634	Switch I region; other site
351746001635	G2 box; other site
351746001636	G3 box; other site
351746001637	Switch II region; other site
351746001638	G4 box; other site
351746001639	G5 box; other site
351746001640	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
351746001641	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
351746001642	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
351746001643	elongation factor Tu; Reviewed; Region: PRK00049
351746001644	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
351746001645	G1 box; other site
351746001646	GEF interaction site [polypeptide binding]; other site
351746001647	GTP/Mg2+ binding site [chemical binding]; other site
351746001648	Switch I region; other site
351746001649	G2 box; other site
351746001650	G3 box; other site
351746001651	Switch II region; other site
351746001652	G4 box; other site
351746001653	G5 box; other site
351746001654	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
351746001655	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
351746001656	Antibiotic Binding Site [chemical binding]; other site
351746001657	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
351746001658	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
351746001659	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
351746001660	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
351746001661	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
351746001662	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
351746001663	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
351746001664	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
351746001665	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
351746001666	protein-rRNA interface [nucleotide binding]; other site
351746001667	putative translocon binding site; other site
351746001668	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
351746001669	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
351746001670	G-X-X-G motif; other site
351746001671	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
351746001672	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
351746001673	23S rRNA interface [nucleotide binding]; other site
351746001674	5S rRNA interface [nucleotide binding]; other site
351746001675	putative antibiotic binding site [chemical binding]; other site
351746001676	L25 interface [polypeptide binding]; other site
351746001677	L27 interface [polypeptide binding]; other site
351746001678	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
351746001679	23S rRNA interface [nucleotide binding]; other site
351746001680	putative translocon interaction site; other site
351746001681	signal recognition particle (SRP54) interaction site; other site
351746001682	L23 interface [polypeptide binding]; other site
351746001683	trigger factor interaction site; other site
351746001684	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
351746001685	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
351746001686	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
351746001687	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
351746001688	RNA binding site [nucleotide binding]; other site
351746001689	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
351746001690	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
351746001691	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
351746001692	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
351746001693	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
351746001694	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
351746001695	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
351746001696	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
351746001697	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
351746001698	5S rRNA interface [nucleotide binding]; other site
351746001699	23S rRNA interface [nucleotide binding]; other site
351746001700	L5 interface [polypeptide binding]; other site
351746001701	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
351746001702	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
351746001703	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
351746001704	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
351746001705	23S rRNA binding site [nucleotide binding]; other site
351746001706	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
351746001707	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
351746001708	SecY translocase; Region: SecY; pfam00344
351746001709	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
351746001710	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
351746001711	30S ribosomal protein S13; Region: bact_S13; TIGR03631
351746001712	30S ribosomal protein S11; Validated; Region: PRK05309
351746001713	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
351746001714	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
351746001715	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746001716	RNA binding surface [nucleotide binding]; other site
351746001717	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
351746001718	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
351746001719	alphaNTD homodimer interface [polypeptide binding]; other site
351746001720	alphaNTD - beta interaction site [polypeptide binding]; other site
351746001721	alphaNTD - beta' interaction site [polypeptide binding]; other site
351746001722	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
351746001723	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
351746001724	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
351746001725	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
351746001726	tetramer interface [polypeptide binding]; other site
351746001727	heme binding pocket [chemical binding]; other site
351746001728	NADPH binding site [chemical binding]; other site
351746001729	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
351746001730	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
351746001731	heme binding site [chemical binding]; other site
351746001732	ferroxidase pore; other site
351746001733	ferroxidase diiron center [ion binding]; other site
351746001734	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
351746001735	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
351746001736	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
351746001737	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
351746001738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746001739	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746001740	putative substrate translocation pore; other site
351746001741	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
351746001742	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351746001743	dimer interface [polypeptide binding]; other site
351746001744	ssDNA binding site [nucleotide binding]; other site
351746001745	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351746001746	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746001747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746001748	DNA-binding site [nucleotide binding]; DNA binding site
351746001749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746001750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746001751	homodimer interface [polypeptide binding]; other site
351746001752	catalytic residue [active]
351746001753	hypothetical protein; Provisional; Region: PRK10621
351746001754	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746001755	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
351746001756	malonic semialdehyde reductase; Provisional; Region: PRK10538
351746001757	putative NAD(P) binding site [chemical binding]; other site
351746001758	homotetramer interface [polypeptide binding]; other site
351746001759	homodimer interface [polypeptide binding]; other site
351746001760	active site
351746001761	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
351746001762	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
351746001763	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
351746001764	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
351746001765	molybdopterin cofactor binding site; other site
351746001766	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
351746001767	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351746001768	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
351746001769	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
351746001770	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
351746001771	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
351746001772	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
351746001773	selenocysteine synthase; Provisional; Region: PRK04311
351746001774	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
351746001775	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
351746001776	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746001777	catalytic residue [active]
351746001778	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
351746001779	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
351746001780	G1 box; other site
351746001781	putative GEF interaction site [polypeptide binding]; other site
351746001782	GTP/Mg2+ binding site [chemical binding]; other site
351746001783	Switch I region; other site
351746001784	G2 box; other site
351746001785	G3 box; other site
351746001786	Switch II region; other site
351746001787	G4 box; other site
351746001788	G5 box; other site
351746001789	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
351746001790	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
351746001791	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
351746001792	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
351746001793	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
351746001794	active site
351746001795	homodimer interface [polypeptide binding]; other site
351746001796	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
351746001797	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
351746001798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746001799	sequence-specific DNA binding site [nucleotide binding]; other site
351746001800	salt bridge; other site
351746001801	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
351746001802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746001803	NAD(P) binding site [chemical binding]; other site
351746001804	active site
351746001805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746001806	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
351746001807	NAD(P) binding site [chemical binding]; other site
351746001808	active site
351746001809	Predicted transcriptional regulators [Transcription]; Region: COG1733
351746001810	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
351746001811	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
351746001812	OmpW family; Region: OmpW; cl17427
351746001813	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
351746001814	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351746001815	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
351746001816	FtsX-like permease family; Region: FtsX; pfam02687
351746001817	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
351746001818	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351746001819	Walker A/P-loop; other site
351746001820	ATP binding site [chemical binding]; other site
351746001821	Q-loop/lid; other site
351746001822	ABC transporter signature motif; other site
351746001823	Walker B; other site
351746001824	D-loop; other site
351746001825	H-loop/switch region; other site
351746001826	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
351746001827	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
351746001828	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
351746001829	Predicted methyltransferase [General function prediction only]; Region: COG3897
351746001830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351746001831	S-adenosylmethionine binding site [chemical binding]; other site
351746001832	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
351746001833	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
351746001834	ATP cone domain; Region: ATP-cone; pfam03477
351746001835	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
351746001836	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
351746001837	catalytic motif [active]
351746001838	Zn binding site [ion binding]; other site
351746001839	RibD C-terminal domain; Region: RibD_C; cl17279
351746001840	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
351746001841	Lumazine binding domain; Region: Lum_binding; pfam00677
351746001842	Lumazine binding domain; Region: Lum_binding; pfam00677
351746001843	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
351746001844	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
351746001845	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
351746001846	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
351746001847	homopentamer interface [polypeptide binding]; other site
351746001848	active site
351746001849	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
351746001850	putative RNA binding site [nucleotide binding]; other site
351746001851	thiamine monophosphate kinase; Provisional; Region: PRK05731
351746001852	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
351746001853	ATP binding site [chemical binding]; other site
351746001854	dimerization interface [polypeptide binding]; other site
351746001855	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
351746001856	tetramer interfaces [polypeptide binding]; other site
351746001857	binuclear metal-binding site [ion binding]; other site
351746001858	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746001859	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746001860	membrane-bound complex binding site; other site
351746001861	hinge residues; other site
351746001862	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
351746001863	dimerization interface [polypeptide binding]; other site
351746001864	active site
351746001865	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
351746001866	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
351746001867	cobalamin binding residues [chemical binding]; other site
351746001868	putative BtuC binding residues; other site
351746001869	dimer interface [polypeptide binding]; other site
351746001870	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
351746001871	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746001872	N-terminal plug; other site
351746001873	ligand-binding site [chemical binding]; other site
351746001874	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
351746001875	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
351746001876	TPP-binding site; other site
351746001877	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
351746001878	PYR/PP interface [polypeptide binding]; other site
351746001879	dimer interface [polypeptide binding]; other site
351746001880	TPP binding site [chemical binding]; other site
351746001881	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351746001882	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
351746001883	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
351746001884	substrate binding pocket [chemical binding]; other site
351746001885	chain length determination region; other site
351746001886	substrate-Mg2+ binding site; other site
351746001887	catalytic residues [active]
351746001888	aspartate-rich region 1; other site
351746001889	active site lid residues [active]
351746001890	aspartate-rich region 2; other site
351746001891	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
351746001892	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
351746001893	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
351746001894	Zeta toxin; Region: Zeta_toxin; pfam06414
351746001895	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
351746001896	Putative esterase; Region: Esterase; pfam00756
351746001897	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746001898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746001899	phosphorylation site [posttranslational modification]
351746001900	dimer interface [polypeptide binding]; other site
351746001901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746001902	ATP binding site [chemical binding]; other site
351746001903	Mg2+ binding site [ion binding]; other site
351746001904	G-X-G motif; other site
351746001905	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746001906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746001907	active site
351746001908	phosphorylation site [posttranslational modification]
351746001909	intermolecular recognition site; other site
351746001910	dimerization interface [polypeptide binding]; other site
351746001911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746001912	DNA binding site [nucleotide binding]
351746001913	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
351746001914	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746001915	N-terminal plug; other site
351746001916	ligand-binding site [chemical binding]; other site
351746001917	Hemerythrin-like domain; Region: Hr-like; cd12108
351746001918	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746001919	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
351746001920	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
351746001921	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
351746001922	Multicopper oxidase; Region: Cu-oxidase; pfam00394
351746001923	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
351746001924	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
351746001925	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746001926	non-specific DNA binding site [nucleotide binding]; other site
351746001927	salt bridge; other site
351746001928	sequence-specific DNA binding site [nucleotide binding]; other site
351746001929	Predicted transcriptional regulator [Transcription]; Region: COG2932
351746001930	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
351746001931	dimer interface [polypeptide binding]; other site
351746001932	substrate binding site [chemical binding]; other site
351746001933	metal binding sites [ion binding]; metal-binding site
351746001934	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
351746001935	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
351746001936	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
351746001937	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
351746001938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746001939	Coenzyme A binding pocket [chemical binding]; other site
351746001940	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
351746001941	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
351746001942	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
351746001943	ethanolamine permease; Region: 2A0305; TIGR00908
351746001944	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
351746001945	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746001946	NAD(P) binding site [chemical binding]; other site
351746001947	catalytic residues [active]
351746001948	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
351746001949	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746001950	Walker A motif; other site
351746001951	ATP binding site [chemical binding]; other site
351746001952	Walker B motif; other site
351746001953	arginine finger; other site
351746001954	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746001955	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
351746001956	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351746001957	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351746001958	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351746001959	aromatic acid decarboxylase; Validated; Region: PRK05920
351746001960	Flavoprotein; Region: Flavoprotein; pfam02441
351746001961	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
351746001962	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
351746001963	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
351746001964	NAD binding site [chemical binding]; other site
351746001965	active site
351746001966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
351746001967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
351746001968	Peptidase C13 family; Region: Peptidase_C13; pfam01650
351746001969	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
351746001970	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
351746001971	putative NAD(P) binding site [chemical binding]; other site
351746001972	catalytic Zn binding site [ion binding]; other site
351746001973	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
351746001974	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351746001975	E3 interaction surface; other site
351746001976	lipoyl attachment site [posttranslational modification]; other site
351746001977	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
351746001978	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
351746001979	alpha subunit interface [polypeptide binding]; other site
351746001980	TPP binding site [chemical binding]; other site
351746001981	heterodimer interface [polypeptide binding]; other site
351746001982	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351746001983	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
351746001984	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
351746001985	tetramer interface [polypeptide binding]; other site
351746001986	TPP-binding site [chemical binding]; other site
351746001987	heterodimer interface [polypeptide binding]; other site
351746001988	phosphorylation loop region [posttranslational modification]
351746001989	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
351746001990	ATP-NAD kinase; Region: NAD_kinase; pfam01513
351746001991	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
351746001992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746001993	Walker A motif; other site
351746001994	ATP binding site [chemical binding]; other site
351746001995	Walker B motif; other site
351746001996	arginine finger; other site
351746001997	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746001998	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
351746001999	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351746002000	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
351746002001	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
351746002002	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
351746002003	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351746002004	carboxyltransferase (CT) interaction site; other site
351746002005	biotinylation site [posttranslational modification]; other site
351746002006	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
351746002007	Dehydroquinase class II; Region: DHquinase_II; pfam01220
351746002008	active site
351746002009	trimer interface [polypeptide binding]; other site
351746002010	dimer interface [polypeptide binding]; other site
351746002011	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
351746002012	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
351746002013	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
351746002014	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
351746002015	DsbD alpha interface [polypeptide binding]; other site
351746002016	catalytic residues [active]
351746002017	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
351746002018	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746002019	dimer interface [polypeptide binding]; other site
351746002020	putative CheW interface [polypeptide binding]; other site
351746002021	Response regulator receiver domain; Region: Response_reg; pfam00072
351746002022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
351746002023	active site
351746002024	phosphorylation site [posttranslational modification]
351746002025	intermolecular recognition site; other site
351746002026	dimerization interface [polypeptide binding]; other site
351746002027	Response regulator receiver domain; Region: Response_reg; pfam00072
351746002028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746002029	active site
351746002030	phosphorylation site [posttranslational modification]
351746002031	intermolecular recognition site; other site
351746002032	dimerization interface [polypeptide binding]; other site
351746002033	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746002034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746002035	metal binding site [ion binding]; metal-binding site
351746002036	active site
351746002037	I-site; other site
351746002038	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
351746002039	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
351746002040	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
351746002041	nudix motif; other site
351746002042	translation initiation factor Sui1; Validated; Region: PRK06824
351746002043	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
351746002044	putative rRNA binding site [nucleotide binding]; other site
351746002045	arginine decarboxylase; Provisional; Region: PRK05354
351746002046	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
351746002047	dimer interface [polypeptide binding]; other site
351746002048	active site
351746002049	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746002050	catalytic residues [active]
351746002051	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
351746002052	Transposase IS200 like; Region: Y1_Tnp; pfam01797
351746002053	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
351746002054	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
351746002055	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
351746002056	MG2 domain; Region: A2M_N; pfam01835
351746002057	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
351746002058	Alpha-2-macroglobulin family; Region: A2M; pfam00207
351746002059	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
351746002060	surface patch; other site
351746002061	thioester region; other site
351746002062	specificity defining residues; other site
351746002063	penicillin-binding protein 1C; Provisional; Region: PRK11240
351746002064	Transglycosylase; Region: Transgly; pfam00912
351746002065	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
351746002066	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
351746002067	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
351746002068	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
351746002069	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746002070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746002071	active site
351746002072	phosphorylation site [posttranslational modification]
351746002073	intermolecular recognition site; other site
351746002074	dimerization interface [polypeptide binding]; other site
351746002075	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746002076	DNA binding residues [nucleotide binding]
351746002077	dimerization interface [polypeptide binding]; other site
351746002078	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
351746002079	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
351746002080	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
351746002081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746002082	S-adenosylmethionine binding site [chemical binding]; other site
351746002083	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
351746002084	homodimer interface [polypeptide binding]; other site
351746002085	chemical substrate binding site [chemical binding]; other site
351746002086	oligomer interface [polypeptide binding]; other site
351746002087	metal binding site [ion binding]; metal-binding site
351746002088	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
351746002089	active site 2 [active]
351746002090	active site 1 [active]
351746002091	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
351746002092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746002093	NAD(P) binding site [chemical binding]; other site
351746002094	active site
351746002095	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
351746002096	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746002097	dimer interface [polypeptide binding]; other site
351746002098	active site
351746002099	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746002100	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746002101	Cache domain; Region: Cache_1; pfam02743
351746002102	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
351746002103	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746002104	dimerization interface [polypeptide binding]; other site
351746002105	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746002106	dimer interface [polypeptide binding]; other site
351746002107	putative CheW interface [polypeptide binding]; other site
351746002108	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
351746002109	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
351746002110	DNA binding residues [nucleotide binding]
351746002111	dimer interface [polypeptide binding]; other site
351746002112	copper binding site [ion binding]; other site
351746002113	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351746002114	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351746002115	metal-binding site [ion binding]
351746002116	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351746002117	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351746002118	metal-binding site [ion binding]
351746002119	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746002120	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351746002121	metal-binding site [ion binding]
351746002122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746002123	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
351746002124	putative substrate translocation pore; other site
351746002125	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
351746002126	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
351746002127	active site
351746002128	purine riboside binding site [chemical binding]; other site
351746002129	short chain dehydrogenase; Provisional; Region: PRK08177
351746002130	C factor cell-cell signaling protein; Provisional; Region: PRK09009
351746002131	NAD(P) binding site [chemical binding]; other site
351746002132	active site
351746002133	Uncharacterized conserved protein [Function unknown]; Region: COG1739
351746002134	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
351746002135	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
351746002136	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
351746002137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746002138	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
351746002139	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746002140	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746002141	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746002142	dimerization interface [polypeptide binding]; other site
351746002143	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
351746002144	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746002145	inhibitor-cofactor binding pocket; inhibition site
351746002146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746002147	catalytic residue [active]
351746002148	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
351746002149	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
351746002150	tetrameric interface [polypeptide binding]; other site
351746002151	NAD binding site [chemical binding]; other site
351746002152	catalytic residues [active]
351746002153	Paraquat-inducible protein A; Region: PqiA; pfam04403
351746002154	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
351746002155	Paraquat-inducible protein A; Region: PqiA; pfam04403
351746002156	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
351746002157	mce related protein; Region: MCE; pfam02470
351746002158	mce related protein; Region: MCE; pfam02470
351746002159	mce related protein; Region: MCE; pfam02470
351746002160	mce related protein; Region: MCE; pfam02470
351746002161	mce related protein; Region: MCE; pfam02470
351746002162	mce related protein; Region: MCE; pfam02470
351746002163	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
351746002164	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
351746002165	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
351746002166	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
351746002167	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
351746002168	active site
351746002169	Riboflavin kinase; Region: Flavokinase; pfam01687
351746002170	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
351746002171	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
351746002172	active site
351746002173	HIGH motif; other site
351746002174	nucleotide binding site [chemical binding]; other site
351746002175	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
351746002176	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
351746002177	active site
351746002178	KMSKS motif; other site
351746002179	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
351746002180	tRNA binding surface [nucleotide binding]; other site
351746002181	anticodon binding site; other site
351746002182	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
351746002183	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
351746002184	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
351746002185	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746002186	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
351746002187	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
351746002188	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
351746002189	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
351746002190	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
351746002191	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
351746002192	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
351746002193	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746002194	putative amidase; Provisional; Region: PRK06169
351746002195	Amidase; Region: Amidase; pfam01425
351746002196	allantoate amidohydrolase; Reviewed; Region: PRK12893
351746002197	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
351746002198	active site
351746002199	metal binding site [ion binding]; metal-binding site
351746002200	dimer interface [polypeptide binding]; other site
351746002201	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
351746002202	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351746002203	Walker A/P-loop; other site
351746002204	ATP binding site [chemical binding]; other site
351746002205	Q-loop/lid; other site
351746002206	ABC transporter signature motif; other site
351746002207	Walker B; other site
351746002208	D-loop; other site
351746002209	H-loop/switch region; other site
351746002210	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
351746002211	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351746002212	Walker A/P-loop; other site
351746002213	ATP binding site [chemical binding]; other site
351746002214	Q-loop/lid; other site
351746002215	ABC transporter signature motif; other site
351746002216	Walker B; other site
351746002217	D-loop; other site
351746002218	H-loop/switch region; other site
351746002219	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
351746002220	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351746002221	TM-ABC transporter signature motif; other site
351746002222	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351746002223	TM-ABC transporter signature motif; other site
351746002224	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
351746002225	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746002226	putative ligand binding site [chemical binding]; other site
351746002227	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746002228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746002229	DNA-binding site [nucleotide binding]; DNA binding site
351746002230	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746002231	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
351746002232	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
351746002233	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746002234	RNA binding surface [nucleotide binding]; other site
351746002235	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
351746002236	active site
351746002237	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
351746002238	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
351746002239	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
351746002240	Clp amino terminal domain; Region: Clp_N; pfam02861
351746002241	Clp amino terminal domain; Region: Clp_N; pfam02861
351746002242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746002243	Walker A motif; other site
351746002244	ATP binding site [chemical binding]; other site
351746002245	Walker B motif; other site
351746002246	arginine finger; other site
351746002247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746002248	Walker A motif; other site
351746002249	ATP binding site [chemical binding]; other site
351746002250	Walker B motif; other site
351746002251	arginine finger; other site
351746002252	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
351746002253	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
351746002254	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746002255	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
351746002256	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
351746002257	Predicted membrane protein [Function unknown]; Region: COG3235
351746002258	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
351746002259	DNA gyrase inhibitor; Reviewed; Region: PRK00418
351746002260	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
351746002261	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
351746002262	CoA-binding site [chemical binding]; other site
351746002263	ATP-binding [chemical binding]; other site
351746002264	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
351746002265	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
351746002266	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
351746002267	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
351746002268	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351746002269	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351746002270	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
351746002271	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
351746002272	Pilin (bacterial filament); Region: Pilin; pfam00114
351746002273	Fic family protein [Function unknown]; Region: COG3177
351746002274	Fic/DOC family; Region: Fic; pfam02661
351746002275	Protein of unknown function (DUF2806); Region: DUF2806; pfam10987
351746002276	GntP family permease; Region: GntP_permease; pfam02447
351746002277	fructuronate transporter; Provisional; Region: PRK10034; cl15264
351746002278	malate dehydrogenase; Reviewed; Region: PRK06223
351746002279	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
351746002280	NAD(P) binding site [chemical binding]; other site
351746002281	dimer interface [polypeptide binding]; other site
351746002282	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351746002283	substrate binding site [chemical binding]; other site
351746002284	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746002285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746002286	dimer interface [polypeptide binding]; other site
351746002287	conserved gate region; other site
351746002288	putative PBP binding loops; other site
351746002289	ABC-ATPase subunit interface; other site
351746002290	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746002291	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746002292	substrate binding pocket [chemical binding]; other site
351746002293	membrane-bound complex binding site; other site
351746002294	hinge residues; other site
351746002295	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
351746002296	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
351746002297	cystathionine gamma-synthase; Provisional; Region: PRK08249
351746002298	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351746002299	homodimer interface [polypeptide binding]; other site
351746002300	substrate-cofactor binding pocket; other site
351746002301	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746002302	catalytic residue [active]
351746002303	S-methylmethionine transporter; Provisional; Region: PRK11387
351746002304	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
351746002305	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746002306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746002307	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746002308	dimerization interface [polypeptide binding]; other site
351746002309	substrate binding pocket [chemical binding]; other site
351746002310	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
351746002311	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
351746002312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746002313	catalytic residue [active]
351746002314	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746002315	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
351746002316	AsnC family; Region: AsnC_trans_reg; pfam01037
351746002317	homoserine dehydrogenase; Provisional; Region: PRK06270
351746002318	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
351746002319	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
351746002320	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746002321	NAD(P) binding site [chemical binding]; other site
351746002322	catalytic residues [active]
351746002323	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
351746002324	homotrimer interaction site [polypeptide binding]; other site
351746002325	putative active site [active]
351746002326	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
351746002327	Sodium Bile acid symporter family; Region: SBF; cl17470
351746002328	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
351746002329	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
351746002330	dimer interface [polypeptide binding]; other site
351746002331	active site
351746002332	glycine-pyridoxal phosphate binding site [chemical binding]; other site
351746002333	folate binding site [chemical binding]; other site
351746002334	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
351746002335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746002336	putative active site [active]
351746002337	heme pocket [chemical binding]; other site
351746002338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746002339	putative active site [active]
351746002340	heme pocket [chemical binding]; other site
351746002341	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746002342	putative active site [active]
351746002343	heme pocket [chemical binding]; other site
351746002344	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746002345	metal binding site [ion binding]; metal-binding site
351746002346	active site
351746002347	I-site; other site
351746002348	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746002349	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
351746002350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746002351	Walker A/P-loop; other site
351746002352	ATP binding site [chemical binding]; other site
351746002353	Q-loop/lid; other site
351746002354	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746002355	ABC transporter signature motif; other site
351746002356	Walker B; other site
351746002357	D-loop; other site
351746002358	ABC transporter; Region: ABC_tran_2; pfam12848
351746002359	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746002360	glutamate dehydrogenase; Provisional; Region: PRK09414
351746002361	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
351746002362	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
351746002363	NAD(P) binding site [chemical binding]; other site
351746002364	transcription elongation factor regulatory protein; Validated; Region: PRK06342
351746002365	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
351746002366	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
351746002367	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
351746002368	AAA domain; Region: AAA_32; pfam13654
351746002369	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
351746002370	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
351746002371	hypothetical protein; Provisional; Region: PRK05208
351746002372	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
351746002373	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
351746002374	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746002375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
351746002376	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
351746002377	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
351746002378	PhnA protein; Region: PhnA; pfam03831
351746002379	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
351746002380	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
351746002381	substrate binding pocket [chemical binding]; other site
351746002382	chain length determination region; other site
351746002383	substrate-Mg2+ binding site; other site
351746002384	catalytic residues [active]
351746002385	aspartate-rich region 1; other site
351746002386	active site lid residues [active]
351746002387	aspartate-rich region 2; other site
351746002388	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
351746002389	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
351746002390	GTPase CgtA; Reviewed; Region: obgE; PRK12298
351746002391	GTP1/OBG; Region: GTP1_OBG; pfam01018
351746002392	Obg GTPase; Region: Obg; cd01898
351746002393	G1 box; other site
351746002394	GTP/Mg2+ binding site [chemical binding]; other site
351746002395	Switch I region; other site
351746002396	G2 box; other site
351746002397	G3 box; other site
351746002398	Switch II region; other site
351746002399	G4 box; other site
351746002400	G5 box; other site
351746002401	gamma-glutamyl kinase; Provisional; Region: PRK05429
351746002402	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
351746002403	nucleotide binding site [chemical binding]; other site
351746002404	homotetrameric interface [polypeptide binding]; other site
351746002405	putative phosphate binding site [ion binding]; other site
351746002406	putative allosteric binding site; other site
351746002407	PUA domain; Region: PUA; pfam01472
351746002408	hypothetical protein; Provisional; Region: PRK10756
351746002409	CreA protein; Region: CreA; pfam05981
351746002410	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
351746002411	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
351746002412	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
351746002413	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
351746002414	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746002415	Coenzyme A binding pocket [chemical binding]; other site
351746002416	Peptidase M15; Region: Peptidase_M15_3; cl01194
351746002417	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746002418	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746002419	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746002420	dimerization interface [polypeptide binding]; other site
351746002421	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746002422	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746002423	FecR protein; Region: FecR; pfam04773
351746002424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746002425	putative substrate translocation pore; other site
351746002426	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746002427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746002428	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746002429	putative substrate translocation pore; other site
351746002430	fec operon regulator FecR; Reviewed; Region: PRK09774
351746002431	FecR protein; Region: FecR; pfam04773
351746002432	RNA polymerase sigma factor; Provisional; Region: PRK12528
351746002433	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746002434	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746002435	DNA binding residues [nucleotide binding]
351746002436	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
351746002437	endonuclease III; Region: ENDO3c; smart00478
351746002438	minor groove reading motif; other site
351746002439	helix-hairpin-helix signature motif; other site
351746002440	substrate binding pocket [chemical binding]; other site
351746002441	active site
351746002442	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
351746002443	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
351746002444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746002445	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
351746002446	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
351746002447	DNA binding site [nucleotide binding]
351746002448	active site
351746002449	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
351746002450	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
351746002451	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746002452	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
351746002453	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746002454	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
351746002455	NAD(P) binding site [chemical binding]; other site
351746002456	catalytic residues [active]
351746002457	catalytic residues [active]
351746002458	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
351746002459	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
351746002460	Na binding site [ion binding]; other site
351746002461	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
351746002462	SnoaL-like domain; Region: SnoaL_3; pfam13474
351746002463	Isochorismatase family; Region: Isochorismatase; pfam00857
351746002464	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
351746002465	catalytic triad [active]
351746002466	dimer interface [polypeptide binding]; other site
351746002467	conserved cis-peptide bond; other site
351746002468	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
351746002469	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
351746002470	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
351746002471	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
351746002472	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
351746002473	multidrug resistance protein MdtN; Provisional; Region: PRK10476
351746002474	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746002475	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746002476	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
351746002477	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
351746002478	Sulfate transporter family; Region: Sulfate_transp; pfam00916
351746002479	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
351746002480	GTP-binding protein YchF; Reviewed; Region: PRK09601
351746002481	YchF GTPase; Region: YchF; cd01900
351746002482	G1 box; other site
351746002483	GTP/Mg2+ binding site [chemical binding]; other site
351746002484	Switch I region; other site
351746002485	G2 box; other site
351746002486	Switch II region; other site
351746002487	G3 box; other site
351746002488	G4 box; other site
351746002489	G5 box; other site
351746002490	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
351746002491	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
351746002492	putative active site [active]
351746002493	catalytic residue [active]
351746002494	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
351746002495	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
351746002496	5S rRNA interface [nucleotide binding]; other site
351746002497	CTC domain interface [polypeptide binding]; other site
351746002498	L16 interface [polypeptide binding]; other site
351746002499	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
351746002500	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
351746002501	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746002502	active site
351746002503	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
351746002504	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
351746002505	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
351746002506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746002507	TPR motif; other site
351746002508	binding surface
351746002509	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
351746002510	binding surface
351746002511	TPR motif; other site
351746002512	TPR repeat; Region: TPR_11; pfam13414
351746002513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746002514	binding surface
351746002515	TPR motif; other site
351746002516	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
351746002517	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
351746002518	tRNA; other site
351746002519	putative tRNA binding site [nucleotide binding]; other site
351746002520	putative NADP binding site [chemical binding]; other site
351746002521	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
351746002522	peptide chain release factor 1; Validated; Region: prfA; PRK00591
351746002523	This domain is found in peptide chain release factors; Region: PCRF; smart00937
351746002524	RF-1 domain; Region: RF-1; pfam00472
351746002525	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
351746002526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746002527	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
351746002528	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
351746002529	ATP binding site [chemical binding]; other site
351746002530	substrate interface [chemical binding]; other site
351746002531	glutamate racemase; Provisional; Region: PRK00865
351746002532	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
351746002533	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746002534	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
351746002535	DNA photolyase; Region: DNA_photolyase; pfam00875
351746002536	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
351746002537	DNA binding residues [nucleotide binding]
351746002538	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
351746002539	Protein of unknown function (DUF523); Region: DUF523; pfam04463
351746002540	Uncharacterized conserved protein [Function unknown]; Region: COG3272
351746002541	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
351746002542	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
351746002543	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746002544	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
351746002545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746002546	NAD(P) binding site [chemical binding]; other site
351746002547	active site
351746002548	ferrochelatase; Reviewed; Region: hemH; PRK00035
351746002549	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
351746002550	C-terminal domain interface [polypeptide binding]; other site
351746002551	active site
351746002552	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
351746002553	active site
351746002554	N-terminal domain interface [polypeptide binding]; other site
351746002555	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
351746002556	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746002557	active site
351746002558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746002559	active site
351746002560	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
351746002561	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
351746002562	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
351746002563	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
351746002564	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
351746002565	putative acyl-acceptor binding pocket; other site
351746002566	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
351746002567	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
351746002568	Uncharacterized conserved protein [Function unknown]; Region: COG2135
351746002569	Peptidase family M48; Region: Peptidase_M48; pfam01435
351746002570	Predicted membrane protein [Function unknown]; Region: COG2119
351746002571	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
351746002572	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
351746002573	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
351746002574	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
351746002575	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746002576	S-adenosylmethionine binding site [chemical binding]; other site
351746002577	glycerate dehydrogenase; Provisional; Region: PRK06487
351746002578	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
351746002579	putative ligand binding site [chemical binding]; other site
351746002580	putative NAD binding site [chemical binding]; other site
351746002581	catalytic site [active]
351746002582	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
351746002583	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746002584	acyl-activating enzyme (AAE) consensus motif; other site
351746002585	AMP binding site [chemical binding]; other site
351746002586	active site
351746002587	CoA binding site [chemical binding]; other site
351746002588	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
351746002589	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
351746002590	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
351746002591	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746002592	DNA binding residues [nucleotide binding]
351746002593	dimerization interface [polypeptide binding]; other site
351746002594	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
351746002595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746002596	active site
351746002597	phosphorylation site [posttranslational modification]
351746002598	intermolecular recognition site; other site
351746002599	dimerization interface [polypeptide binding]; other site
351746002600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746002601	binding surface
351746002602	TPR motif; other site
351746002603	TPR repeat; Region: TPR_11; pfam13414
351746002604	TPR repeat; Region: TPR_11; pfam13414
351746002605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746002606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746002607	ATP binding site [chemical binding]; other site
351746002608	Mg2+ binding site [ion binding]; other site
351746002609	G-X-G motif; other site
351746002610	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
351746002611	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746002612	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746002613	ligand binding site [chemical binding]; other site
351746002614	phosphate acetyltransferase; Reviewed; Region: PRK05632
351746002615	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351746002616	DRTGG domain; Region: DRTGG; pfam07085
351746002617	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
351746002618	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
351746002619	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
351746002620	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746002621	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
351746002622	catalytic residues [active]
351746002623	dimer interface [polypeptide binding]; other site
351746002624	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746002625	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
351746002626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746002627	PAS domain; Region: PAS_9; pfam13426
351746002628	putative active site [active]
351746002629	heme pocket [chemical binding]; other site
351746002630	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746002631	PAS domain; Region: PAS_9; pfam13426
351746002632	putative active site [active]
351746002633	heme pocket [chemical binding]; other site
351746002634	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746002635	dimer interface [polypeptide binding]; other site
351746002636	putative CheW interface [polypeptide binding]; other site
351746002637	GAD-like domain; Region: GAD-like; pfam08887
351746002638	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
351746002639	putative sulfate transport protein CysZ; Validated; Region: PRK04949
351746002640	thioredoxin reductase; Provisional; Region: PRK10262
351746002641	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746002642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746002643	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
351746002644	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
351746002645	dimerization interface [polypeptide binding]; other site
351746002646	active site
351746002647	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
351746002648	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
351746002649	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
351746002650	amidase catalytic site [active]
351746002651	Zn binding residues [ion binding]; other site
351746002652	substrate binding site [chemical binding]; other site
351746002653	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
351746002654	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
351746002655	active site
351746002656	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
351746002657	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351746002658	DNA binding site [nucleotide binding]
351746002659	domain linker motif; other site
351746002660	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
351746002661	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
351746002662	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
351746002663	active site
351746002664	phosphorylation site [posttranslational modification]
351746002665	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
351746002666	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
351746002667	dimerization domain swap beta strand [polypeptide binding]; other site
351746002668	regulatory protein interface [polypeptide binding]; other site
351746002669	active site
351746002670	regulatory phosphorylation site [posttranslational modification]; other site
351746002671	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
351746002672	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
351746002673	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
351746002674	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
351746002675	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
351746002676	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
351746002677	putative substrate binding site [chemical binding]; other site
351746002678	putative ATP binding site [chemical binding]; other site
351746002679	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
351746002680	active site
351746002681	P-loop; other site
351746002682	phosphorylation site [posttranslational modification]
351746002683	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
351746002684	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
351746002685	active site
351746002686	P-loop; other site
351746002687	phosphorylation site [posttranslational modification]
351746002688	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
351746002689	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
351746002690	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
351746002691	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746002692	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746002693	metal binding site [ion binding]; metal-binding site
351746002694	active site
351746002695	I-site; other site
351746002696	outer membrane porin, OprD family; Region: OprD; pfam03573
351746002697	Flagellin N-methylase; Region: FliB; pfam03692
351746002698	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351746002699	Response regulator receiver domain; Region: Response_reg; pfam00072
351746002700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746002701	active site
351746002702	phosphorylation site [posttranslational modification]
351746002703	intermolecular recognition site; other site
351746002704	dimerization interface [polypeptide binding]; other site
351746002705	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
351746002706	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746002707	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746002708	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
351746002709	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746002710	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746002711	Walker A/P-loop; other site
351746002712	ATP binding site [chemical binding]; other site
351746002713	Q-loop/lid; other site
351746002714	ABC transporter signature motif; other site
351746002715	Walker B; other site
351746002716	D-loop; other site
351746002717	H-loop/switch region; other site
351746002718	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
351746002719	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
351746002720	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
351746002721	GAF domain; Region: GAF; pfam01590
351746002722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746002723	Walker A motif; other site
351746002724	ATP binding site [chemical binding]; other site
351746002725	Walker B motif; other site
351746002726	arginine finger; other site
351746002727	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
351746002728	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
351746002729	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
351746002730	heme-binding site [chemical binding]; other site
351746002731	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
351746002732	FAD binding pocket [chemical binding]; other site
351746002733	FAD binding motif [chemical binding]; other site
351746002734	phosphate binding motif [ion binding]; other site
351746002735	beta-alpha-beta structure motif; other site
351746002736	NAD binding pocket [chemical binding]; other site
351746002737	Heme binding  pocket [chemical binding]; other site
351746002738	disulfide bond formation protein B; Provisional; Region: PRK02110
351746002739	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
351746002740	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
351746002741	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
351746002742	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
351746002743	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
351746002744	D-pathway; other site
351746002745	Putative ubiquinol binding site [chemical binding]; other site
351746002746	Low-spin heme (heme b) binding site [chemical binding]; other site
351746002747	Putative water exit pathway; other site
351746002748	Binuclear center (heme o3/CuB) [ion binding]; other site
351746002749	K-pathway; other site
351746002750	Putative proton exit pathway; other site
351746002751	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
351746002752	Subunit I/III interface [polypeptide binding]; other site
351746002753	Subunit III/IV interface [polypeptide binding]; other site
351746002754	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
351746002755	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
351746002756	UbiA prenyltransferase family; Region: UbiA; pfam01040
351746002757	aminotransferase; Validated; Region: PRK08175
351746002758	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746002759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746002760	homodimer interface [polypeptide binding]; other site
351746002761	catalytic residue [active]
351746002762	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
351746002763	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351746002764	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746002765	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
351746002766	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746002767	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
351746002768	DNA binding residues [nucleotide binding]
351746002769	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746002770	FecR protein; Region: FecR; pfam04773
351746002771	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746002772	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
351746002773	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746002774	N-terminal plug; other site
351746002775	ligand-binding site [chemical binding]; other site
351746002776	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
351746002777	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
351746002778	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
351746002779	active site residue [active]
351746002780	selenophosphate synthetase; Provisional; Region: PRK00943
351746002781	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
351746002782	dimerization interface [polypeptide binding]; other site
351746002783	putative ATP binding site [chemical binding]; other site
351746002784	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
351746002785	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746002786	substrate binding pocket [chemical binding]; other site
351746002787	membrane-bound complex binding site; other site
351746002788	hinge residues; other site
351746002789	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
351746002790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746002791	dimer interface [polypeptide binding]; other site
351746002792	conserved gate region; other site
351746002793	putative PBP binding loops; other site
351746002794	ABC-ATPase subunit interface; other site
351746002795	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
351746002796	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
351746002797	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
351746002798	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
351746002799	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
351746002800	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746002801	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746002802	Coenzyme A binding pocket [chemical binding]; other site
351746002803	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
351746002804	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
351746002805	dimer interface [polypeptide binding]; other site
351746002806	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746002807	ligand binding site [chemical binding]; other site
351746002808	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746002809	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746002810	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
351746002811	homotrimer interaction site [polypeptide binding]; other site
351746002812	putative active site [active]
351746002813	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
351746002814	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
351746002815	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
351746002816	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
351746002817	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
351746002818	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
351746002819	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
351746002820	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
351746002821	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
351746002822	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
351746002823	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
351746002824	Protein export membrane protein; Region: SecD_SecF; pfam02355
351746002825	hypothetical protein; Provisional; Region: PRK11280
351746002826	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
351746002827	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
351746002828	active site
351746002829	dimerization interface [polypeptide binding]; other site
351746002830	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
351746002831	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
351746002832	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
351746002833	serine O-acetyltransferase; Region: cysE; TIGR01172
351746002834	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
351746002835	trimer interface [polypeptide binding]; other site
351746002836	active site
351746002837	substrate binding site [chemical binding]; other site
351746002838	CoA binding site [chemical binding]; other site
351746002839	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
351746002840	Rrf2 family protein; Region: rrf2_super; TIGR00738
351746002841	cysteine desulfurase; Provisional; Region: PRK14012
351746002842	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
351746002843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746002844	catalytic residue [active]
351746002845	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
351746002846	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
351746002847	trimerization site [polypeptide binding]; other site
351746002848	active site
351746002849	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
351746002850	co-chaperone HscB; Provisional; Region: hscB; PRK00294
351746002851	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
351746002852	HSP70 interaction site [polypeptide binding]; other site
351746002853	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
351746002854	chaperone protein HscA; Provisional; Region: hscA; PRK05183
351746002855	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
351746002856	nucleotide binding site [chemical binding]; other site
351746002857	putative NEF/HSP70 interaction site [polypeptide binding]; other site
351746002858	SBD interface [polypeptide binding]; other site
351746002859	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
351746002860	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746002861	catalytic loop [active]
351746002862	iron binding site [ion binding]; other site
351746002863	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
351746002864	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
351746002865	active site
351746002866	multimer interface [polypeptide binding]; other site
351746002867	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
351746002868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746002869	FeS/SAM binding site; other site
351746002870	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
351746002871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746002872	TPR motif; other site
351746002873	binding surface
351746002874	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
351746002875	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746002876	non-specific DNA binding site [nucleotide binding]; other site
351746002877	salt bridge; other site
351746002878	sequence-specific DNA binding site [nucleotide binding]; other site
351746002879	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
351746002880	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
351746002881	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
351746002882	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
351746002883	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
351746002884	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
351746002885	dimer interface [polypeptide binding]; other site
351746002886	motif 1; other site
351746002887	active site
351746002888	motif 2; other site
351746002889	motif 3; other site
351746002890	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
351746002891	anticodon binding site; other site
351746002892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
351746002893	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
351746002894	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
351746002895	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
351746002896	Trp docking motif [polypeptide binding]; other site
351746002897	active site
351746002898	GTP-binding protein Der; Reviewed; Region: PRK00093
351746002899	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
351746002900	G1 box; other site
351746002901	GTP/Mg2+ binding site [chemical binding]; other site
351746002902	Switch I region; other site
351746002903	G2 box; other site
351746002904	Switch II region; other site
351746002905	G3 box; other site
351746002906	G4 box; other site
351746002907	G5 box; other site
351746002908	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
351746002909	G1 box; other site
351746002910	GTP/Mg2+ binding site [chemical binding]; other site
351746002911	Switch I region; other site
351746002912	G2 box; other site
351746002913	G3 box; other site
351746002914	Switch II region; other site
351746002915	G4 box; other site
351746002916	G5 box; other site
351746002917	methionine aminotransferase; Validated; Region: PRK09082
351746002918	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746002919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746002920	homodimer interface [polypeptide binding]; other site
351746002921	catalytic residue [active]
351746002922	C-N hydrolase family amidase; Provisional; Region: PRK10438
351746002923	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
351746002924	putative active site [active]
351746002925	catalytic triad [active]
351746002926	dimer interface [polypeptide binding]; other site
351746002927	multimer interface [polypeptide binding]; other site
351746002928	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
351746002929	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
351746002930	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
351746002931	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
351746002932	Flavodoxin; Region: Flavodoxin_1; pfam00258
351746002933	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
351746002934	FAD binding pocket [chemical binding]; other site
351746002935	FAD binding motif [chemical binding]; other site
351746002936	catalytic residues [active]
351746002937	NAD binding pocket [chemical binding]; other site
351746002938	phosphate binding motif [ion binding]; other site
351746002939	beta-alpha-beta structure motif; other site
351746002940	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
351746002941	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746002942	N-terminal plug; other site
351746002943	ligand-binding site [chemical binding]; other site
351746002944	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
351746002945	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
351746002946	Sel1 repeat; Region: Sel1; cl02723
351746002947	Sel1-like repeats; Region: SEL1; smart00671
351746002948	Sel1 repeat; Region: Sel1; cl02723
351746002949	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
351746002950	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
351746002951	dimer interface [polypeptide binding]; other site
351746002952	active site
351746002953	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746002954	catalytic residues [active]
351746002955	substrate binding site [chemical binding]; other site
351746002956	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746002957	RNA polymerase sigma factor; Reviewed; Region: PRK12527
351746002958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746002959	DNA binding residues [nucleotide binding]
351746002960	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746002961	FecR protein; Region: FecR; pfam04773
351746002962	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
351746002963	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746002964	N-terminal plug; other site
351746002965	ligand-binding site [chemical binding]; other site
351746002966	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
351746002967	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
351746002968	Walker A/P-loop; other site
351746002969	ATP binding site [chemical binding]; other site
351746002970	Q-loop/lid; other site
351746002971	ABC transporter signature motif; other site
351746002972	Walker B; other site
351746002973	D-loop; other site
351746002974	H-loop/switch region; other site
351746002975	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
351746002976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746002977	dimer interface [polypeptide binding]; other site
351746002978	conserved gate region; other site
351746002979	ABC-ATPase subunit interface; other site
351746002980	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
351746002981	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
351746002982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746002983	dimer interface [polypeptide binding]; other site
351746002984	conserved gate region; other site
351746002985	putative PBP binding loops; other site
351746002986	ABC-ATPase subunit interface; other site
351746002987	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
351746002988	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
351746002989	G1 box; other site
351746002990	putative GEF interaction site [polypeptide binding]; other site
351746002991	GTP/Mg2+ binding site [chemical binding]; other site
351746002992	Switch I region; other site
351746002993	G2 box; other site
351746002994	G3 box; other site
351746002995	Switch II region; other site
351746002996	G4 box; other site
351746002997	G5 box; other site
351746002998	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
351746002999	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746003000	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746003001	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
351746003002	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746003003	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746003004	SnoaL-like domain; Region: SnoaL_2; pfam12680
351746003005	Helix-turn-helix domain; Region: HTH_18; pfam12833
351746003006	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746003007	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
351746003008	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746003009	active site
351746003010	metal binding site [ion binding]; metal-binding site
351746003011	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
351746003012	hypothetical protein; Provisional; Region: PRK07206
351746003013	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
351746003014	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
351746003015	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
351746003016	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
351746003017	EamA-like transporter family; Region: EamA; cl17759
351746003018	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746003019	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746003020	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746003021	putative effector binding pocket; other site
351746003022	dimerization interface [polypeptide binding]; other site
351746003023	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
351746003024	Rubredoxin; Region: Rubredoxin; pfam00301
351746003025	iron binding site [ion binding]; other site
351746003026	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
351746003027	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351746003028	Walker A/P-loop; other site
351746003029	ATP binding site [chemical binding]; other site
351746003030	Q-loop/lid; other site
351746003031	ABC transporter signature motif; other site
351746003032	Walker B; other site
351746003033	D-loop; other site
351746003034	H-loop/switch region; other site
351746003035	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
351746003036	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
351746003037	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351746003038	Walker A/P-loop; other site
351746003039	ATP binding site [chemical binding]; other site
351746003040	Q-loop/lid; other site
351746003041	ABC transporter signature motif; other site
351746003042	Walker B; other site
351746003043	D-loop; other site
351746003044	H-loop/switch region; other site
351746003045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
351746003046	dipeptide transporter; Provisional; Region: PRK10913
351746003047	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
351746003048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746003049	putative PBP binding loops; other site
351746003050	dimer interface [polypeptide binding]; other site
351746003051	ABC-ATPase subunit interface; other site
351746003052	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
351746003053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746003054	dimer interface [polypeptide binding]; other site
351746003055	conserved gate region; other site
351746003056	putative PBP binding loops; other site
351746003057	ABC-ATPase subunit interface; other site
351746003058	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
351746003059	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
351746003060	peptide binding site [polypeptide binding]; other site
351746003061	outer membrane porin, OprD family; Region: OprD; pfam03573
351746003062	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
351746003063	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
351746003064	peptide binding site [polypeptide binding]; other site
351746003065	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
351746003066	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
351746003067	peptide binding site [polypeptide binding]; other site
351746003068	Protein of unknown function (DUF541); Region: SIMPL; cl01077
351746003069	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746003070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746003071	ATP binding site [chemical binding]; other site
351746003072	G-X-G motif; other site
351746003073	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
351746003074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746003075	active site
351746003076	phosphorylation site [posttranslational modification]
351746003077	intermolecular recognition site; other site
351746003078	dimerization interface [polypeptide binding]; other site
351746003079	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746003080	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
351746003081	Beta-lactamase; Region: Beta-lactamase; pfam00144
351746003082	YceI-like domain; Region: YceI; pfam04264
351746003083	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
351746003084	PLD-like domain; Region: PLDc_2; pfam13091
351746003085	putative active site [active]
351746003086	catalytic site [active]
351746003087	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
351746003088	PLD-like domain; Region: PLDc_2; pfam13091
351746003089	putative active site [active]
351746003090	catalytic site [active]
351746003091	intracellular protease, PfpI family; Region: PfpI; TIGR01382
351746003092	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
351746003093	conserved cys residue [active]
351746003094	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
351746003095	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746003096	Coenzyme A binding pocket [chemical binding]; other site
351746003097	Predicted amidohydrolase [General function prediction only]; Region: COG0388
351746003098	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
351746003099	putative active site [active]
351746003100	catalytic triad [active]
351746003101	putative dimer interface [polypeptide binding]; other site
351746003102	putative fumarate hydratase; Provisional; Region: PRK15392
351746003103	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
351746003104	Fumarase C-terminus; Region: Fumerase_C; pfam05683
351746003105	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
351746003106	hypothetical protein; Provisional; Region: PRK05713
351746003107	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746003108	catalytic loop [active]
351746003109	iron binding site [ion binding]; other site
351746003110	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
351746003111	FAD binding pocket [chemical binding]; other site
351746003112	FAD binding motif [chemical binding]; other site
351746003113	phosphate binding motif [ion binding]; other site
351746003114	beta-alpha-beta structure motif; other site
351746003115	NAD binding pocket [chemical binding]; other site
351746003116	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
351746003117	active site
351746003118	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746003119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746003120	active site
351746003121	phosphorylation site [posttranslational modification]
351746003122	intermolecular recognition site; other site
351746003123	dimerization interface [polypeptide binding]; other site
351746003124	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746003125	DNA binding site [nucleotide binding]
351746003126	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746003127	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
351746003128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746003129	dimer interface [polypeptide binding]; other site
351746003130	phosphorylation site [posttranslational modification]
351746003131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746003132	ATP binding site [chemical binding]; other site
351746003133	Mg2+ binding site [ion binding]; other site
351746003134	G-X-G motif; other site
351746003135	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351746003136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746003137	S-adenosylmethionine binding site [chemical binding]; other site
351746003138	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
351746003139	multidrug efflux protein; Reviewed; Region: PRK09579
351746003140	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746003141	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746003142	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746003143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
351746003144	Imelysin; Region: Peptidase_M75; cl09159
351746003145	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
351746003146	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
351746003147	Imelysin; Region: Peptidase_M75; cl09159
351746003148	biofilm formation regulator HmsP; Provisional; Region: PRK11829
351746003149	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746003150	metal binding site [ion binding]; metal-binding site
351746003151	active site
351746003152	I-site; other site
351746003153	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746003154	superoxide dismutase; Provisional; Region: PRK10543
351746003155	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
351746003156	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
351746003157	Lysine efflux permease [General function prediction only]; Region: COG1279
351746003158	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
351746003159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746003160	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746003161	dimerization interface [polypeptide binding]; other site
351746003162	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
351746003163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746003164	NAD(P) binding site [chemical binding]; other site
351746003165	active site
351746003166	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
351746003167	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
351746003168	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
351746003169	FMN binding site [chemical binding]; other site
351746003170	active site
351746003171	substrate binding site [chemical binding]; other site
351746003172	catalytic residue [active]
351746003173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746003174	dimerization interface [polypeptide binding]; other site
351746003175	putative DNA binding site [nucleotide binding]; other site
351746003176	putative Zn2+ binding site [ion binding]; other site
351746003177	Protein of unknown function, DUF479; Region: DUF479; cl01203
351746003178	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
351746003179	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
351746003180	putative acyl-acceptor binding pocket; other site
351746003181	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
351746003182	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746003183	Predicted permeases [General function prediction only]; Region: COG0679
351746003184	aromatic amino acid transporter; Provisional; Region: PRK10238
351746003185	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
351746003186	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
351746003187	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
351746003188	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
351746003189	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
351746003190	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
351746003191	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
351746003192	GatB domain; Region: GatB_Yqey; smart00845
351746003193	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
351746003194	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
351746003195	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
351746003196	rod shape-determining protein MreB; Provisional; Region: PRK13927
351746003197	MreB and similar proteins; Region: MreB_like; cd10225
351746003198	nucleotide binding site [chemical binding]; other site
351746003199	Mg binding site [ion binding]; other site
351746003200	putative protofilament interaction site [polypeptide binding]; other site
351746003201	RodZ interaction site [polypeptide binding]; other site
351746003202	rod shape-determining protein MreC; Provisional; Region: PRK13922
351746003203	rod shape-determining protein MreC; Region: MreC; pfam04085
351746003204	rod shape-determining protein MreD; Region: MreD; cl01087
351746003205	Maf-like protein; Region: Maf; pfam02545
351746003206	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
351746003207	active site
351746003208	dimer interface [polypeptide binding]; other site
351746003209	ribonuclease G; Provisional; Region: PRK11712
351746003210	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
351746003211	homodimer interface [polypeptide binding]; other site
351746003212	oligonucleotide binding site [chemical binding]; other site
351746003213	TIGR02099 family protein; Region: TIGR02099
351746003214	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
351746003215	nitrilase; Region: PLN02798
351746003216	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
351746003217	putative active site [active]
351746003218	catalytic triad [active]
351746003219	dimer interface [polypeptide binding]; other site
351746003220	protease TldD; Provisional; Region: tldD; PRK10735
351746003221	hypothetical protein; Provisional; Region: PRK05255
351746003222	peptidase PmbA; Provisional; Region: PRK11040
351746003223	fumarate hydratase; Reviewed; Region: fumC; PRK00485
351746003224	Class II fumarases; Region: Fumarase_classII; cd01362
351746003225	active site
351746003226	tetramer interface [polypeptide binding]; other site
351746003227	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
351746003228	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
351746003229	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
351746003230	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
351746003231	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
351746003232	dimerization domain swap beta strand [polypeptide binding]; other site
351746003233	regulatory protein interface [polypeptide binding]; other site
351746003234	active site
351746003235	regulatory phosphorylation site [posttranslational modification]; other site
351746003236	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
351746003237	AAA domain; Region: AAA_18; pfam13238
351746003238	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
351746003239	active site
351746003240	phosphorylation site [posttranslational modification]
351746003241	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
351746003242	30S subunit binding site; other site
351746003243	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
351746003244	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
351746003245	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
351746003246	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
351746003247	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
351746003248	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
351746003249	Walker A/P-loop; other site
351746003250	ATP binding site [chemical binding]; other site
351746003251	Q-loop/lid; other site
351746003252	ABC transporter signature motif; other site
351746003253	Walker B; other site
351746003254	D-loop; other site
351746003255	H-loop/switch region; other site
351746003256	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
351746003257	OstA-like protein; Region: OstA; pfam03968
351746003258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
351746003259	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
351746003260	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
351746003261	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
351746003262	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
351746003263	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
351746003264	putative active site [active]
351746003265	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
351746003266	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
351746003267	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
351746003268	Walker A/P-loop; other site
351746003269	ATP binding site [chemical binding]; other site
351746003270	Q-loop/lid; other site
351746003271	ABC transporter signature motif; other site
351746003272	Walker B; other site
351746003273	D-loop; other site
351746003274	H-loop/switch region; other site
351746003275	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
351746003276	Permease; Region: Permease; cl00510
351746003277	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
351746003278	mce related protein; Region: MCE; pfam02470
351746003279	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
351746003280	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
351746003281	anti sigma factor interaction site; other site
351746003282	regulatory phosphorylation site [posttranslational modification]; other site
351746003283	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
351746003284	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
351746003285	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
351746003286	hinge; other site
351746003287	active site
351746003288	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
351746003289	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
351746003290	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
351746003291	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
351746003292	NAD binding site [chemical binding]; other site
351746003293	dimerization interface [polypeptide binding]; other site
351746003294	product binding site; other site
351746003295	substrate binding site [chemical binding]; other site
351746003296	zinc binding site [ion binding]; other site
351746003297	catalytic residues [active]
351746003298	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
351746003299	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746003300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746003301	homodimer interface [polypeptide binding]; other site
351746003302	catalytic residue [active]
351746003303	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
351746003304	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746003305	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746003306	DNA-binding site [nucleotide binding]; DNA binding site
351746003307	FCD domain; Region: FCD; pfam07729
351746003308	cyanate transporter; Region: CynX; TIGR00896
351746003309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746003310	putative substrate translocation pore; other site
351746003311	SnoaL-like domain; Region: SnoaL_2; pfam12680
351746003312	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
351746003313	GIY-YIG motif/motif A; other site
351746003314	putative active site [active]
351746003315	putative metal binding site [ion binding]; other site
351746003316	Nucleoid-associated protein [General function prediction only]; Region: COG3081
351746003317	nucleoid-associated protein NdpA; Validated; Region: PRK00378
351746003318	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351746003319	IHF - DNA interface [nucleotide binding]; other site
351746003320	IHF dimer interface [polypeptide binding]; other site
351746003321	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
351746003322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746003323	S-adenosylmethionine binding site [chemical binding]; other site
351746003324	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
351746003325	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
351746003326	HIGH motif; other site
351746003327	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
351746003328	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
351746003329	active site
351746003330	KMSKS motif; other site
351746003331	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
351746003332	tRNA binding surface [nucleotide binding]; other site
351746003333	anticodon binding site; other site
351746003334	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
351746003335	DNA polymerase III subunit chi; Validated; Region: PRK05728
351746003336	multifunctional aminopeptidase A; Provisional; Region: PRK00913
351746003337	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
351746003338	interface (dimer of trimers) [polypeptide binding]; other site
351746003339	Substrate-binding/catalytic site; other site
351746003340	Zn-binding sites [ion binding]; other site
351746003341	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
351746003342	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
351746003343	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
351746003344	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
351746003345	RDD family; Region: RDD; pfam06271
351746003346	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351746003347	DNA-binding site [nucleotide binding]; DNA binding site
351746003348	RNA-binding motif; other site
351746003349	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
351746003350	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
351746003351	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
351746003352	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
351746003353	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
351746003354	glycine dehydrogenase; Provisional; Region: PRK05367
351746003355	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
351746003356	tetramer interface [polypeptide binding]; other site
351746003357	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746003358	catalytic residue [active]
351746003359	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
351746003360	tetramer interface [polypeptide binding]; other site
351746003361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746003362	catalytic residue [active]
351746003363	glycine cleavage system protein H; Provisional; Region: PRK13380
351746003364	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
351746003365	lipoyl attachment site [posttranslational modification]; other site
351746003366	Predicted membrane protein [Function unknown]; Region: COG2259
351746003367	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
351746003368	hypothetical protein; Provisional; Region: PRK05409
351746003369	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
351746003370	RNA polymerase sigma factor; Provisional; Region: PRK12536
351746003371	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746003372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746003373	DNA binding residues [nucleotide binding]
351746003374	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
351746003375	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
351746003376	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
351746003377	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
351746003378	putative aromatic amino acid binding site; other site
351746003379	PAS domain; Region: PAS; smart00091
351746003380	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746003381	Walker A motif; other site
351746003382	ATP binding site [chemical binding]; other site
351746003383	Walker B motif; other site
351746003384	arginine finger; other site
351746003385	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
351746003386	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
351746003387	putative substrate binding site [chemical binding]; other site
351746003388	nucleotide binding site [chemical binding]; other site
351746003389	nucleotide binding site [chemical binding]; other site
351746003390	homodimer interface [polypeptide binding]; other site
351746003391	ornithine carbamoyltransferase; Validated; Region: PRK02102
351746003392	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
351746003393	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
351746003394	arginine deiminase; Provisional; Region: PRK01388
351746003395	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
351746003396	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
351746003397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
351746003398	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
351746003399	heme binding pocket [chemical binding]; other site
351746003400	heme ligand [chemical binding]; other site
351746003401	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746003402	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
351746003403	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746003404	N-terminal plug; other site
351746003405	ligand-binding site [chemical binding]; other site
351746003406	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746003407	FecR protein; Region: FecR; pfam04773
351746003408	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
351746003409	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746003410	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746003411	DNA binding residues [nucleotide binding]
351746003412	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351746003413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351746003414	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351746003415	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
351746003416	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
351746003417	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
351746003418	phosphogluconate dehydratase; Validated; Region: PRK09054
351746003419	6-phosphogluconate dehydratase; Region: edd; TIGR01196
351746003420	glucokinase; Provisional; Region: glk; PRK00292
351746003421	glucokinase, proteobacterial type; Region: glk; TIGR00749
351746003422	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746003423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746003424	active site
351746003425	phosphorylation site [posttranslational modification]
351746003426	intermolecular recognition site; other site
351746003427	dimerization interface [polypeptide binding]; other site
351746003428	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746003429	DNA binding site [nucleotide binding]
351746003430	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
351746003431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746003432	ATP binding site [chemical binding]; other site
351746003433	Mg2+ binding site [ion binding]; other site
351746003434	G-X-G motif; other site
351746003435	dimerization interface [polypeptide binding]; other site
351746003436	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
351746003437	putative active cleft [active]
351746003438	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351746003439	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351746003440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746003441	dimer interface [polypeptide binding]; other site
351746003442	conserved gate region; other site
351746003443	putative PBP binding loops; other site
351746003444	ABC-ATPase subunit interface; other site
351746003445	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351746003446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746003447	dimer interface [polypeptide binding]; other site
351746003448	conserved gate region; other site
351746003449	putative PBP binding loops; other site
351746003450	ABC-ATPase subunit interface; other site
351746003451	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
351746003452	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
351746003453	Walker A/P-loop; other site
351746003454	ATP binding site [chemical binding]; other site
351746003455	Q-loop/lid; other site
351746003456	ABC transporter signature motif; other site
351746003457	Walker B; other site
351746003458	D-loop; other site
351746003459	H-loop/switch region; other site
351746003460	TOBE domain; Region: TOBE_2; pfam08402
351746003461	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
351746003462	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
351746003463	active site
351746003464	phosphate binding residues; other site
351746003465	catalytic residues [active]
351746003466	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
351746003467	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
351746003468	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
351746003469	putative active site [active]
351746003470	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
351746003471	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
351746003472	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
351746003473	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
351746003474	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
351746003475	putative active site [active]
351746003476	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
351746003477	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
351746003478	active site
351746003479	intersubunit interface [polypeptide binding]; other site
351746003480	catalytic residue [active]
351746003481	2-isopropylmalate synthase; Validated; Region: PRK03739
351746003482	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
351746003483	active site
351746003484	catalytic residues [active]
351746003485	metal binding site [ion binding]; metal-binding site
351746003486	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
351746003487	Glypican; Region: Glypican; pfam01153
351746003488	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351746003489	Peptidase family M23; Region: Peptidase_M23; pfam01551
351746003490	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
351746003491	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
351746003492	generic binding surface II; other site
351746003493	generic binding surface I; other site
351746003494	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746003495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746003496	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
351746003497	dimerization interface [polypeptide binding]; other site
351746003498	substrate binding pocket [chemical binding]; other site
351746003499	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746003500	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
351746003501	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
351746003502	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
351746003503	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
351746003504	active site
351746003505	GMP synthase; Reviewed; Region: guaA; PRK00074
351746003506	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
351746003507	AMP/PPi binding site [chemical binding]; other site
351746003508	candidate oxyanion hole; other site
351746003509	catalytic triad [active]
351746003510	potential glutamine specificity residues [chemical binding]; other site
351746003511	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
351746003512	ATP Binding subdomain [chemical binding]; other site
351746003513	Ligand Binding sites [chemical binding]; other site
351746003514	Dimerization subdomain; other site
351746003515	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
351746003516	NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129
351746003517	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
351746003518	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
351746003519	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
351746003520	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
351746003521	nucleoside/Zn binding site; other site
351746003522	dimer interface [polypeptide binding]; other site
351746003523	catalytic motif [active]
351746003524	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
351746003525	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746003526	substrate binding pocket [chemical binding]; other site
351746003527	membrane-bound complex binding site; other site
351746003528	hinge residues; other site
351746003529	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746003530	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746003531	catalytic residue [active]
351746003532	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
351746003533	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
351746003534	dimerization interface [polypeptide binding]; other site
351746003535	ATP binding site [chemical binding]; other site
351746003536	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
351746003537	dimerization interface [polypeptide binding]; other site
351746003538	ATP binding site [chemical binding]; other site
351746003539	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
351746003540	putative active site [active]
351746003541	catalytic triad [active]
351746003542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
351746003543	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
351746003544	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
351746003545	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
351746003546	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
351746003547	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
351746003548	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
351746003549	active site
351746003550	metal binding site [ion binding]; metal-binding site
351746003551	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
351746003552	type II secretion system protein D; Region: type_II_gspD; TIGR02517
351746003553	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
351746003554	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
351746003555	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
351746003556	type II secretion system protein E; Region: type_II_gspE; TIGR02533
351746003557	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
351746003558	Walker A motif; other site
351746003559	ATP binding site [chemical binding]; other site
351746003560	Walker B motif; other site
351746003561	type II secretion system protein F; Region: GspF; TIGR02120
351746003562	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351746003563	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351746003564	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
351746003565	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
351746003566	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
351746003567	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
351746003568	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
351746003569	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
351746003570	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
351746003571	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
351746003572	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
351746003573	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
351746003574	GspL periplasmic domain; Region: GspL_C; cl14909
351746003575	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
351746003576	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
351746003577	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
351746003578	FAD binding pocket [chemical binding]; other site
351746003579	FAD binding motif [chemical binding]; other site
351746003580	phosphate binding motif [ion binding]; other site
351746003581	NAD binding pocket [chemical binding]; other site
351746003582	Predicted transcriptional regulators [Transcription]; Region: COG1695
351746003583	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
351746003584	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
351746003585	Transglycosylase; Region: Transgly; pfam00912
351746003586	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
351746003587	Spore germination protein; Region: Spore_permease; cl17796
351746003588	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
351746003589	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
351746003590	active site
351746003591	FMN binding site [chemical binding]; other site
351746003592	substrate binding site [chemical binding]; other site
351746003593	3Fe-4S cluster binding site [ion binding]; other site
351746003594	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
351746003595	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746003596	ATP binding site [chemical binding]; other site
351746003597	putative Mg++ binding site [ion binding]; other site
351746003598	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746003599	nucleotide binding region [chemical binding]; other site
351746003600	ATP-binding site [chemical binding]; other site
351746003601	DEAD/H associated; Region: DEAD_assoc; pfam08494
351746003602	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
351746003603	nudix motif; other site
351746003604	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
351746003605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746003606	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
351746003607	putative dimerization interface [polypeptide binding]; other site
351746003608	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
351746003609	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
351746003610	GlpM protein; Region: GlpM; pfam06942
351746003611	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746003612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746003613	active site
351746003614	phosphorylation site [posttranslational modification]
351746003615	intermolecular recognition site; other site
351746003616	dimerization interface [polypeptide binding]; other site
351746003617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746003618	Walker A motif; other site
351746003619	ATP binding site [chemical binding]; other site
351746003620	Walker B motif; other site
351746003621	arginine finger; other site
351746003622	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746003623	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
351746003624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746003625	dimer interface [polypeptide binding]; other site
351746003626	phosphorylation site [posttranslational modification]
351746003627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746003628	Mg2+ binding site [ion binding]; other site
351746003629	G-X-G motif; other site
351746003630	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
351746003631	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746003632	Walker A/P-loop; other site
351746003633	ATP binding site [chemical binding]; other site
351746003634	Q-loop/lid; other site
351746003635	ABC transporter signature motif; other site
351746003636	Walker B; other site
351746003637	D-loop; other site
351746003638	H-loop/switch region; other site
351746003639	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746003640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746003641	dimer interface [polypeptide binding]; other site
351746003642	conserved gate region; other site
351746003643	putative PBP binding loops; other site
351746003644	ABC-ATPase subunit interface; other site
351746003645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746003646	dimer interface [polypeptide binding]; other site
351746003647	conserved gate region; other site
351746003648	putative PBP binding loops; other site
351746003649	ABC-ATPase subunit interface; other site
351746003650	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
351746003651	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746003652	substrate binding pocket [chemical binding]; other site
351746003653	membrane-bound complex binding site; other site
351746003654	hinge residues; other site
351746003655	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
351746003656	Leucine rich repeat; Region: LRR_8; pfam13855
351746003657	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
351746003658	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
351746003659	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
351746003660	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351746003661	glycerol kinase; Provisional; Region: glpK; PRK00047
351746003662	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
351746003663	N- and C-terminal domain interface [polypeptide binding]; other site
351746003664	active site
351746003665	MgATP binding site [chemical binding]; other site
351746003666	catalytic site [active]
351746003667	metal binding site [ion binding]; metal-binding site
351746003668	glycerol binding site [chemical binding]; other site
351746003669	homotetramer interface [polypeptide binding]; other site
351746003670	homodimer interface [polypeptide binding]; other site
351746003671	protein IIAGlc interface [polypeptide binding]; other site
351746003672	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
351746003673	amphipathic channel; other site
351746003674	Asn-Pro-Ala signature motifs; other site
351746003675	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
351746003676	putative deacylase active site [active]
351746003677	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
351746003678	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
351746003679	Walker A/P-loop; other site
351746003680	ATP binding site [chemical binding]; other site
351746003681	Q-loop/lid; other site
351746003682	ABC transporter signature motif; other site
351746003683	Walker B; other site
351746003684	D-loop; other site
351746003685	H-loop/switch region; other site
351746003686	TOBE domain; Region: TOBE_2; pfam08402
351746003687	ornithine carbamoyltransferase; Provisional; Region: PRK00779
351746003688	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
351746003689	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
351746003690	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
351746003691	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
351746003692	putative [Fe4-S4] binding site [ion binding]; other site
351746003693	putative molybdopterin cofactor binding site [chemical binding]; other site
351746003694	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
351746003695	putative molybdopterin cofactor binding site; other site
351746003696	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
351746003697	putative GSH binding site [chemical binding]; other site
351746003698	catalytic residues [active]
351746003699	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
351746003700	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
351746003701	heme binding site [chemical binding]; other site
351746003702	ferroxidase pore; other site
351746003703	ferroxidase diiron center [ion binding]; other site
351746003704	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
351746003705	peroxidase; Provisional; Region: PRK15000
351746003706	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
351746003707	dimer interface [polypeptide binding]; other site
351746003708	decamer (pentamer of dimers) interface [polypeptide binding]; other site
351746003709	catalytic triad [active]
351746003710	peroxidatic and resolving cysteines [active]
351746003711	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
351746003712	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
351746003713	dimer interface [polypeptide binding]; other site
351746003714	catalytic site [active]
351746003715	putative active site [active]
351746003716	putative substrate binding site [chemical binding]; other site
351746003717	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
351746003718	active site
351746003719	substrate binding pocket [chemical binding]; other site
351746003720	dimer interface [polypeptide binding]; other site
351746003721	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746003722	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746003723	ligand binding site [chemical binding]; other site
351746003724	argininosuccinate synthase; Provisional; Region: PRK13820
351746003725	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
351746003726	ANP binding site [chemical binding]; other site
351746003727	Substrate Binding Site II [chemical binding]; other site
351746003728	Substrate Binding Site I [chemical binding]; other site
351746003729	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746003730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746003731	active site
351746003732	phosphorylation site [posttranslational modification]
351746003733	intermolecular recognition site; other site
351746003734	dimerization interface [polypeptide binding]; other site
351746003735	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746003736	DNA binding residues [nucleotide binding]
351746003737	dimerization interface [polypeptide binding]; other site
351746003738	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
351746003739	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
351746003740	minor groove reading motif; other site
351746003741	helix-hairpin-helix signature motif; other site
351746003742	substrate binding pocket [chemical binding]; other site
351746003743	active site
351746003744	electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947
351746003745	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
351746003746	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
351746003747	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
351746003748	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
351746003749	active site
351746003750	HIGH motif; other site
351746003751	KMSKS motif; other site
351746003752	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
351746003753	tRNA binding surface [nucleotide binding]; other site
351746003754	anticodon binding site; other site
351746003755	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
351746003756	dimer interface [polypeptide binding]; other site
351746003757	putative tRNA-binding site [nucleotide binding]; other site
351746003758	antiporter inner membrane protein; Provisional; Region: PRK11670
351746003759	Domain of unknown function DUF59; Region: DUF59; pfam01883
351746003760	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
351746003761	Walker A motif; other site
351746003762	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351746003763	DNA-binding site [nucleotide binding]; DNA binding site
351746003764	RNA-binding motif; other site
351746003765	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
351746003766	trimer interface [polypeptide binding]; other site
351746003767	active site
351746003768	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
351746003769	putative active site [active]
351746003770	putative metal binding site [ion binding]; other site
351746003771	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
351746003772	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746003773	ATP binding site [chemical binding]; other site
351746003774	putative Mg++ binding site [ion binding]; other site
351746003775	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746003776	nucleotide binding region [chemical binding]; other site
351746003777	ATP-binding site [chemical binding]; other site
351746003778	DEAD/H associated; Region: DEAD_assoc; pfam08494
351746003779	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
351746003780	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
351746003781	active site
351746003782	Zn binding site [ion binding]; other site
351746003783	ATP-dependent DNA ligase; Validated; Region: PRK09247
351746003784	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
351746003785	active site
351746003786	DNA binding site [nucleotide binding]
351746003787	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
351746003788	DNA binding site [nucleotide binding]
351746003789	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
351746003790	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
351746003791	Penicillin amidase; Region: Penicil_amidase; pfam01804
351746003792	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
351746003793	active site
351746003794	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746003795	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746003796	DNA-binding site [nucleotide binding]; DNA binding site
351746003797	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746003798	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746003799	homodimer interface [polypeptide binding]; other site
351746003800	catalytic residue [active]
351746003801	serine O-acetyltransferase; Region: cysE; TIGR01172
351746003802	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
351746003803	trimer interface [polypeptide binding]; other site
351746003804	active site
351746003805	substrate binding site [chemical binding]; other site
351746003806	CoA binding site [chemical binding]; other site
351746003807	alanine-tRNA ligase; Region: PLN02961
351746003808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746003809	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746003810	putative substrate translocation pore; other site
351746003811	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
351746003812	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
351746003813	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746003814	catalytic residue [active]
351746003815	SEC-C motif; Region: SEC-C; pfam02810
351746003816	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
351746003817	hypothetical protein; Provisional; Region: PRK00183
351746003818	SEC-C motif; Region: SEC-C; pfam02810
351746003819	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746003820	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746003821	ligand binding site [chemical binding]; other site
351746003822	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746003823	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746003824	ligand binding site [chemical binding]; other site
351746003825	Protein of unknown function (DUF1145); Region: DUF1145; pfam06611
351746003826	Predicted integral membrane protein [Function unknown]; Region: COG5615
351746003827	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
351746003828	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
351746003829	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
351746003830	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
351746003831	Beta-lactamase; Region: Beta-lactamase; pfam00144
351746003832	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746003833	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746003834	ligand binding site [chemical binding]; other site
351746003835	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
351746003836	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
351746003837	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
351746003838	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
351746003839	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
351746003840	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
351746003841	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746003842	Predicted membrane protein [Function unknown]; Region: COG3650
351746003843	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
351746003844	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351746003845	Walker A/P-loop; other site
351746003846	ATP binding site [chemical binding]; other site
351746003847	Q-loop/lid; other site
351746003848	ABC transporter signature motif; other site
351746003849	Walker B; other site
351746003850	D-loop; other site
351746003851	H-loop/switch region; other site
351746003852	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
351746003853	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351746003854	Walker A/P-loop; other site
351746003855	ATP binding site [chemical binding]; other site
351746003856	Q-loop/lid; other site
351746003857	ABC transporter signature motif; other site
351746003858	Walker B; other site
351746003859	D-loop; other site
351746003860	H-loop/switch region; other site
351746003861	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
351746003862	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
351746003863	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351746003864	TM-ABC transporter signature motif; other site
351746003865	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746003866	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351746003867	TM-ABC transporter signature motif; other site
351746003868	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
351746003869	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
351746003870	dimerization interface [polypeptide binding]; other site
351746003871	ligand binding site [chemical binding]; other site
351746003872	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
351746003873	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
351746003874	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
351746003875	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
351746003876	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
351746003877	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
351746003878	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746003879	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746003880	metal binding site [ion binding]; metal-binding site
351746003881	active site
351746003882	I-site; other site
351746003883	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746003884	ATP-dependent helicase HepA; Validated; Region: PRK04914
351746003885	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746003886	ATP binding site [chemical binding]; other site
351746003887	putative Mg++ binding site [ion binding]; other site
351746003888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746003889	nucleotide binding region [chemical binding]; other site
351746003890	ATP-binding site [chemical binding]; other site
351746003891	Fusaric acid resistance protein family; Region: FUSC; pfam04632
351746003892	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
351746003893	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
351746003894	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746003895	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746003896	Protein of unknown function (DUF2025); Region: DUF2025; pfam09634
351746003897	CHASE4 domain; Region: CHASE4; pfam05228
351746003898	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746003899	PAS domain; Region: PAS_9; pfam13426
351746003900	putative active site [active]
351746003901	heme pocket [chemical binding]; other site
351746003902	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746003903	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746003904	metal binding site [ion binding]; metal-binding site
351746003905	active site
351746003906	I-site; other site
351746003907	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746003908	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
351746003909	MASE2 domain; Region: MASE2; pfam05230
351746003910	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746003911	metal binding site [ion binding]; metal-binding site
351746003912	active site
351746003913	I-site; other site
351746003914	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
351746003915	acetolactate synthase; Reviewed; Region: PRK08322
351746003916	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746003917	PYR/PP interface [polypeptide binding]; other site
351746003918	dimer interface [polypeptide binding]; other site
351746003919	TPP binding site [chemical binding]; other site
351746003920	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746003921	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
351746003922	TPP-binding site [chemical binding]; other site
351746003923	dimer interface [polypeptide binding]; other site
351746003924	Predicted amidohydrolase [General function prediction only]; Region: COG0388
351746003925	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
351746003926	putative active site [active]
351746003927	catalytic triad [active]
351746003928	putative dimer interface [polypeptide binding]; other site
351746003929	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
351746003930	active site
351746003931	homotetramer interface [polypeptide binding]; other site
351746003932	homodimer interface [polypeptide binding]; other site
351746003933	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
351746003934	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746003935	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
351746003936	putative C-terminal domain interface [polypeptide binding]; other site
351746003937	putative GSH binding site (G-site) [chemical binding]; other site
351746003938	putative dimer interface [polypeptide binding]; other site
351746003939	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
351746003940	putative N-terminal domain interface [polypeptide binding]; other site
351746003941	putative dimer interface [polypeptide binding]; other site
351746003942	putative substrate binding pocket (H-site) [chemical binding]; other site
351746003943	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
351746003944	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
351746003945	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
351746003946	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
351746003947	FAD binding pocket [chemical binding]; other site
351746003948	FAD binding motif [chemical binding]; other site
351746003949	phosphate binding motif [ion binding]; other site
351746003950	beta-alpha-beta structure motif; other site
351746003951	NAD binding pocket [chemical binding]; other site
351746003952	Heme binding  pocket [chemical binding]; other site
351746003953	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
351746003954	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746003955	catalytic loop [active]
351746003956	iron binding site [ion binding]; other site
351746003957	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746003958	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746003959	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
351746003960	putative effector binding pocket; other site
351746003961	putative dimerization interface [polypeptide binding]; other site
351746003962	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
351746003963	active site
351746003964	catalytic residues [active]
351746003965	DctM-like transporters; Region: DctM; pfam06808
351746003966	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
351746003967	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
351746003968	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
351746003969	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
351746003970	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
351746003971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746003972	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
351746003973	extended (e) SDRs; Region: SDR_e; cd08946
351746003974	active site
351746003975	active site
351746003976	substrate binding site [chemical binding]; other site
351746003977	outer membrane porin, OprD family; Region: OprD; pfam03573
351746003978	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
351746003979	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
351746003980	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
351746003981	dimer interface [polypeptide binding]; other site
351746003982	putative radical transfer pathway; other site
351746003983	diiron center [ion binding]; other site
351746003984	tyrosyl radical; other site
351746003985	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
351746003986	ATP cone domain; Region: ATP-cone; pfam03477
351746003987	ATP cone domain; Region: ATP-cone; pfam03477
351746003988	Class I ribonucleotide reductase; Region: RNR_I; cd01679
351746003989	active site
351746003990	dimer interface [polypeptide binding]; other site
351746003991	catalytic residues [active]
351746003992	effector binding site; other site
351746003993	R2 peptide binding site; other site
351746003994	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746003995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746003996	active site
351746003997	phosphorylation site [posttranslational modification]
351746003998	intermolecular recognition site; other site
351746003999	dimerization interface [polypeptide binding]; other site
351746004000	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746004001	DNA binding site [nucleotide binding]
351746004002	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746004003	dimerization interface [polypeptide binding]; other site
351746004004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746004005	dimer interface [polypeptide binding]; other site
351746004006	phosphorylation site [posttranslational modification]
351746004007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746004008	ATP binding site [chemical binding]; other site
351746004009	Mg2+ binding site [ion binding]; other site
351746004010	G-X-G motif; other site
351746004011	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
351746004012	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
351746004013	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
351746004014	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746004015	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
351746004016	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
351746004017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004018	active site
351746004019	phosphorylation site [posttranslational modification]
351746004020	intermolecular recognition site; other site
351746004021	dimerization interface [polypeptide binding]; other site
351746004022	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746004023	DNA binding site [nucleotide binding]
351746004024	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746004025	dimer interface [polypeptide binding]; other site
351746004026	phosphorylation site [posttranslational modification]
351746004027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746004028	ATP binding site [chemical binding]; other site
351746004029	Mg2+ binding site [ion binding]; other site
351746004030	G-X-G motif; other site
351746004031	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
351746004032	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746004033	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
351746004034	homodimer interaction site [polypeptide binding]; other site
351746004035	cofactor binding site; other site
351746004036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
351746004037	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
351746004038	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
351746004039	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
351746004040	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746004041	RNA binding surface [nucleotide binding]; other site
351746004042	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
351746004043	active site
351746004044	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
351746004045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746004046	Coenzyme A binding pocket [chemical binding]; other site
351746004047	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
351746004048	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
351746004049	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746004050	FeS/SAM binding site; other site
351746004051	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
351746004052	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
351746004053	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
351746004054	Predicted integral membrane protein [Function unknown]; Region: COG0392
351746004055	Uncharacterized conserved protein [Function unknown]; Region: COG2898
351746004056	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
351746004057	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
351746004058	active site
351746004059	DNA polymerase IV; Validated; Region: PRK02406
351746004060	DNA binding site [nucleotide binding]
351746004061	prolyl-tRNA synthetase; Provisional; Region: PRK09194
351746004062	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
351746004063	dimer interface [polypeptide binding]; other site
351746004064	motif 1; other site
351746004065	active site
351746004066	motif 2; other site
351746004067	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
351746004068	putative deacylase active site [active]
351746004069	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
351746004070	active site
351746004071	motif 3; other site
351746004072	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
351746004073	anticodon binding site; other site
351746004074	outer membrane porin, OprD family; Region: OprD; pfam03573
351746004075	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
351746004076	nucleotide binding site/active site [active]
351746004077	HIT family signature motif; other site
351746004078	catalytic residue [active]
351746004079	hypothetical protein; Provisional; Region: PRK00295
351746004080	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351746004081	DNA-binding site [nucleotide binding]; DNA binding site
351746004082	RNA-binding motif; other site
351746004083	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
351746004084	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
351746004085	dimerization interface [polypeptide binding]; other site
351746004086	DPS ferroxidase diiron center [ion binding]; other site
351746004087	ion pore; other site
351746004088	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
351746004089	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
351746004090	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
351746004091	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
351746004092	dimer interface [polypeptide binding]; other site
351746004093	anticodon binding site; other site
351746004094	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
351746004095	homodimer interface [polypeptide binding]; other site
351746004096	motif 1; other site
351746004097	active site
351746004098	motif 2; other site
351746004099	GAD domain; Region: GAD; pfam02938
351746004100	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
351746004101	active site
351746004102	motif 3; other site
351746004103	hypothetical protein; Validated; Region: PRK00110
351746004104	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
351746004105	active site
351746004106	putative DNA-binding cleft [nucleotide binding]; other site
351746004107	dimer interface [polypeptide binding]; other site
351746004108	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
351746004109	RuvA N terminal domain; Region: RuvA_N; pfam01330
351746004110	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
351746004111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746004112	Walker A motif; other site
351746004113	ATP binding site [chemical binding]; other site
351746004114	Walker B motif; other site
351746004115	arginine finger; other site
351746004116	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
351746004117	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
351746004118	active site
351746004119	TolQ protein; Region: tolQ; TIGR02796
351746004120	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
351746004121	TolR protein; Region: tolR; TIGR02801
351746004122	TolA protein; Region: tolA_full; TIGR02794
351746004123	TolA protein; Region: tolA_full; TIGR02794
351746004124	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
351746004125	translocation protein TolB; Provisional; Region: tolB; PRK00178
351746004126	TolB amino-terminal domain; Region: TolB_N; pfam04052
351746004127	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
351746004128	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
351746004129	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
351746004130	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746004131	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746004132	ligand binding site [chemical binding]; other site
351746004133	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
351746004134	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
351746004135	binding surface
351746004136	TPR motif; other site
351746004137	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
351746004138	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
351746004139	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
351746004140	Ligand Binding Site [chemical binding]; other site
351746004141	Cation efflux family; Region: Cation_efflux; cl00316
351746004142	Cache domain; Region: Cache_1; pfam02743
351746004143	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746004144	dimerization interface [polypeptide binding]; other site
351746004145	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746004146	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746004147	dimer interface [polypeptide binding]; other site
351746004148	putative CheW interface [polypeptide binding]; other site
351746004149	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
351746004150	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
351746004151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
351746004152	quinolinate synthetase; Provisional; Region: PRK09375
351746004153	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351746004154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351746004155	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351746004156	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
351746004157	Peptidase family M48; Region: Peptidase_M48; cl12018
351746004158	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
351746004159	CPxP  motif; other site
351746004160	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
351746004161	Domain of unknown function DUF20; Region: UPF0118; pfam01594
351746004162	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
351746004163	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
351746004164	catalytic triad [active]
351746004165	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
351746004166	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
351746004167	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
351746004168	dihydrodipicolinate synthase; Region: dapA; TIGR00674
351746004169	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
351746004170	dimer interface [polypeptide binding]; other site
351746004171	active site
351746004172	catalytic residue [active]
351746004173	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
351746004174	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
351746004175	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
351746004176	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
351746004177	ATP binding site [chemical binding]; other site
351746004178	active site
351746004179	substrate binding site [chemical binding]; other site
351746004180	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
351746004181	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746004182	Bacterial SH3 domain; Region: SH3_3; pfam08239
351746004183	LysE type translocator; Region: LysE; cl00565
351746004184	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
351746004185	malate:quinone oxidoreductase; Validated; Region: PRK05257
351746004186	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
351746004187	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746004188	dimerization interface [polypeptide binding]; other site
351746004189	putative DNA binding site [nucleotide binding]; other site
351746004190	putative Zn2+ binding site [ion binding]; other site
351746004191	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
351746004192	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
351746004193	active site
351746004194	FMN binding site [chemical binding]; other site
351746004195	substrate binding site [chemical binding]; other site
351746004196	homotetramer interface [polypeptide binding]; other site
351746004197	catalytic residue [active]
351746004198	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746004199	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351746004200	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
351746004201	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
351746004202	dimer interface [polypeptide binding]; other site
351746004203	NADP binding site [chemical binding]; other site
351746004204	catalytic residues [active]
351746004205	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
351746004206	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
351746004207	inhibitor site; inhibition site
351746004208	active site
351746004209	dimer interface [polypeptide binding]; other site
351746004210	catalytic residue [active]
351746004211	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
351746004212	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
351746004213	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
351746004214	PAS fold; Region: PAS_4; pfam08448
351746004215	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746004216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746004217	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746004218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004219	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746004220	dimerization interface [polypeptide binding]; other site
351746004221	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
351746004222	MPT binding site; other site
351746004223	trimer interface [polypeptide binding]; other site
351746004224	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
351746004225	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
351746004226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746004227	FeS/SAM binding site; other site
351746004228	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
351746004229	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
351746004230	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
351746004231	putative molybdopterin cofactor binding site [chemical binding]; other site
351746004232	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
351746004233	putative molybdopterin cofactor binding site; other site
351746004234	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746004235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746004236	putative DNA binding site [nucleotide binding]; other site
351746004237	putative Zn2+ binding site [ion binding]; other site
351746004238	AsnC family; Region: AsnC_trans_reg; pfam01037
351746004239	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
351746004240	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351746004241	homodimer interface [polypeptide binding]; other site
351746004242	substrate-cofactor binding pocket; other site
351746004243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746004244	catalytic residue [active]
351746004245	Protein of unknown function (DUF465); Region: DUF465; pfam04325
351746004246	putative metal dependent hydrolase; Provisional; Region: PRK11598
351746004247	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
351746004248	Sulfatase; Region: Sulfatase; pfam00884
351746004249	ribonuclease D; Region: rnd; TIGR01388
351746004250	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
351746004251	catalytic site [active]
351746004252	putative active site [active]
351746004253	putative substrate binding site [chemical binding]; other site
351746004254	HRDC domain; Region: HRDC; pfam00570
351746004255	YcgL domain; Region: YcgL; pfam05166
351746004256	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
351746004257	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
351746004258	NAD binding site [chemical binding]; other site
351746004259	ligand binding site [chemical binding]; other site
351746004260	catalytic site [active]
351746004261	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
351746004262	putative FMN binding site [chemical binding]; other site
351746004263	hypothetical protein; Provisional; Region: PRK05170
351746004264	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
351746004265	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
351746004266	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
351746004267	active site
351746004268	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
351746004269	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746004270	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
351746004271	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
351746004272	putative active site [active]
351746004273	putative dimer interface [polypeptide binding]; other site
351746004274	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
351746004275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746004276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746004278	dimerization interface [polypeptide binding]; other site
351746004279	benzoate transport; Region: 2A0115; TIGR00895
351746004280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746004281	putative substrate translocation pore; other site
351746004282	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
351746004283	putative active site [active]
351746004284	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
351746004285	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
351746004286	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
351746004287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
351746004288	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746004289	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746004290	Walker A motif; other site
351746004291	ATP binding site [chemical binding]; other site
351746004292	Walker B motif; other site
351746004293	arginine finger; other site
351746004294	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
351746004295	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
351746004296	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
351746004297	dimer interface [polypeptide binding]; other site
351746004298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746004299	catalytic residue [active]
351746004300	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
351746004301	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
351746004302	EamA-like transporter family; Region: EamA; pfam00892
351746004303	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
351746004304	EamA-like transporter family; Region: EamA; pfam00892
351746004305	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
351746004306	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
351746004307	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
351746004308	S1 domain; Region: S1_2; pfam13509
351746004309	S1 domain; Region: S1_2; pfam13509
351746004310	CsbD-like; Region: CsbD; pfam05532
351746004311	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
351746004312	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
351746004313	active site
351746004314	catalytic residues [active]
351746004315	metal binding site [ion binding]; metal-binding site
351746004316	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746004317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746004318	Coenzyme A binding pocket [chemical binding]; other site
351746004319	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746004320	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
351746004321	SnoaL-like domain; Region: SnoaL_3; pfam13474
351746004322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
351746004323	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
351746004324	putative hydrophobic ligand binding site [chemical binding]; other site
351746004325	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
351746004326	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746004327	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
351746004328	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
351746004329	dimer interaction site [polypeptide binding]; other site
351746004330	substrate-binding tunnel; other site
351746004331	active site
351746004332	catalytic site [active]
351746004333	substrate binding site [chemical binding]; other site
351746004334	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
351746004335	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746004336	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746004337	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
351746004338	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
351746004339	acyl-activating enzyme (AAE) consensus motif; other site
351746004340	putative AMP binding site [chemical binding]; other site
351746004341	putative active site [active]
351746004342	putative CoA binding site [chemical binding]; other site
351746004343	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
351746004344	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
351746004345	acyl-activating enzyme (AAE) consensus motif; other site
351746004346	putative AMP binding site [chemical binding]; other site
351746004347	putative active site [active]
351746004348	putative CoA binding site [chemical binding]; other site
351746004349	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746004350	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746004351	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746004352	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746004353	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
351746004354	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746004355	ATP binding site [chemical binding]; other site
351746004356	putative Mg++ binding site [ion binding]; other site
351746004357	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746004358	nucleotide binding region [chemical binding]; other site
351746004359	ATP-binding site [chemical binding]; other site
351746004360	Helicase associated domain (HA2); Region: HA2; pfam04408
351746004361	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
351746004362	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
351746004363	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
351746004364	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
351746004365	dimer interface [polypeptide binding]; other site
351746004366	active site
351746004367	CoA binding pocket [chemical binding]; other site
351746004368	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
351746004369	Protein of unknown function, DUF482; Region: DUF482; pfam04339
351746004370	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351746004371	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746004372	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
351746004373	Walker A/P-loop; other site
351746004374	ATP binding site [chemical binding]; other site
351746004375	Q-loop/lid; other site
351746004376	ABC transporter signature motif; other site
351746004377	Walker B; other site
351746004378	D-loop; other site
351746004379	H-loop/switch region; other site
351746004380	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
351746004381	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
351746004382	substrate binding site [chemical binding]; other site
351746004383	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
351746004384	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746004385	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746004386	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004387	LysR substrate binding domain; Region: LysR_substrate; pfam03466
351746004388	dimerization interface [polypeptide binding]; other site
351746004389	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
351746004390	azoreductase; Reviewed; Region: PRK00170
351746004391	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746004392	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
351746004393	Transposase domain (DUF772); Region: DUF772; pfam05598
351746004394	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
351746004395	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
351746004396	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
351746004397	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
351746004398	arogenate dehydrogenase; Region: PLN02256
351746004399	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
351746004400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
351746004401	hypothetical protein; Provisional; Region: PRK09262
351746004402	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
351746004403	outer membrane porin, OprD family; Region: OprD; pfam03573
351746004404	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
351746004405	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746004406	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
351746004407	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
351746004408	active site
351746004409	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746004410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004411	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
351746004412	putative dimerization interface [polypeptide binding]; other site
351746004413	hypothetical protein; Validated; Region: PRK06201
351746004414	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
351746004415	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
351746004416	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
351746004417	ligand binding site [chemical binding]; other site
351746004418	NAD binding site [chemical binding]; other site
351746004419	dimerization interface [polypeptide binding]; other site
351746004420	catalytic site [active]
351746004421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746004422	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746004423	putative substrate translocation pore; other site
351746004424	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
351746004425	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746004426	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
351746004427	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
351746004428	Transposase; Region: HTH_Tnp_1; pfam01527
351746004429	Transposase, Mutator family; Region: Transposase_mut; pfam00872
351746004430	MULE transposase domain; Region: MULE; pfam10551
351746004431	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746004432	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
351746004433	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746004434	helicase 45; Provisional; Region: PTZ00424
351746004435	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
351746004436	ATP binding site [chemical binding]; other site
351746004437	Mg++ binding site [ion binding]; other site
351746004438	motif III; other site
351746004439	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746004440	nucleotide binding region [chemical binding]; other site
351746004441	ATP-binding site [chemical binding]; other site
351746004442	Protein of unknown function (DUF497); Region: DUF497; pfam04365
351746004443	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
351746004444	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351746004445	EamA-like transporter family; Region: EamA; pfam00892
351746004446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746004447	putative substrate translocation pore; other site
351746004448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746004449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004450	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
351746004451	putative dimerization interface [polypeptide binding]; other site
351746004452	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
351746004453	Na binding site [ion binding]; other site
351746004454	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
351746004455	agmatinase; Region: agmatinase; TIGR01230
351746004456	oligomer interface [polypeptide binding]; other site
351746004457	putative active site [active]
351746004458	Mn binding site [ion binding]; other site
351746004459	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746004460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004461	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746004462	dimerization interface [polypeptide binding]; other site
351746004463	PAS domain; Region: PAS_9; pfam13426
351746004464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746004465	putative active site [active]
351746004466	heme pocket [chemical binding]; other site
351746004467	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746004468	dimer interface [polypeptide binding]; other site
351746004469	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
351746004470	putative CheW interface [polypeptide binding]; other site
351746004471	DTW domain; Region: DTW; cl01221
351746004472	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
351746004473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
351746004474	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
351746004475	yecA family protein; Region: ygfB_yecA; TIGR02292
351746004476	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
351746004477	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746004478	ATP binding site [chemical binding]; other site
351746004479	putative Mg++ binding site [ion binding]; other site
351746004480	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746004481	nucleotide binding region [chemical binding]; other site
351746004482	ATP-binding site [chemical binding]; other site
351746004483	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
351746004484	HRDC domain; Region: HRDC; pfam00570
351746004485	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351746004486	MarR family; Region: MarR_2; pfam12802
351746004487	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
351746004488	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
351746004489	active site
351746004490	nucleophile elbow; other site
351746004491	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746004492	Surface antigen; Region: Bac_surface_Ag; pfam01103
351746004493	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
351746004494	EamA-like transporter family; Region: EamA; pfam00892
351746004495	Cupin domain; Region: Cupin_2; cl17218
351746004496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746004497	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746004498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746004499	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
351746004500	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
351746004501	putative active site [active]
351746004502	putative metal binding site [ion binding]; other site
351746004503	Protein of unknown function (DUF962); Region: DUF962; pfam06127
351746004504	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746004505	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746004506	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746004507	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
351746004508	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
351746004509	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
351746004510	putative FMN binding site [chemical binding]; other site
351746004511	two-component sensor protein; Provisional; Region: cpxA; PRK09470
351746004512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
351746004513	dimerization interface [polypeptide binding]; other site
351746004514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746004515	ATP binding site [chemical binding]; other site
351746004516	Mg2+ binding site [ion binding]; other site
351746004517	G-X-G motif; other site
351746004518	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
351746004519	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746004520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004521	active site
351746004522	phosphorylation site [posttranslational modification]
351746004523	intermolecular recognition site; other site
351746004524	dimerization interface [polypeptide binding]; other site
351746004525	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746004526	DNA binding site [nucleotide binding]
351746004527	YciI-like protein; Reviewed; Region: PRK11370
351746004528	intracellular septation protein A; Reviewed; Region: PRK00259
351746004529	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
351746004530	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
351746004531	active site
351746004532	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
351746004533	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
351746004534	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
351746004535	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
351746004536	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
351746004537	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746004538	RNA binding surface [nucleotide binding]; other site
351746004539	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
351746004540	probable active site [active]
351746004541	aromatic amino acid transporter; Provisional; Region: PRK10238
351746004542	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746004543	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746004544	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746004545	dimerization interface [polypeptide binding]; other site
351746004546	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
351746004547	FAD binding domain; Region: FAD_binding_4; pfam01565
351746004548	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
351746004549	major facilitator superfamily transporter; Provisional; Region: PRK05122
351746004550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746004551	putative substrate translocation pore; other site
351746004552	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
351746004553	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
351746004554	aromatic arch; other site
351746004555	DCoH dimer interaction site [polypeptide binding]; other site
351746004556	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
351746004557	DCoH tetramer interaction site [polypeptide binding]; other site
351746004558	substrate binding site [chemical binding]; other site
351746004559	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
351746004560	cofactor binding site; other site
351746004561	metal binding site [ion binding]; metal-binding site
351746004562	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
351746004563	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
351746004564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746004565	putative active site [active]
351746004566	heme pocket [chemical binding]; other site
351746004567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746004568	Walker A motif; other site
351746004569	ATP binding site [chemical binding]; other site
351746004570	Walker B motif; other site
351746004571	arginine finger; other site
351746004572	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351746004573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351746004574	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351746004575	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746004576	acetyl-CoA synthetase; Provisional; Region: PRK00174
351746004577	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
351746004578	active site
351746004579	CoA binding site [chemical binding]; other site
351746004580	acyl-activating enzyme (AAE) consensus motif; other site
351746004581	AMP binding site [chemical binding]; other site
351746004582	acetate binding site [chemical binding]; other site
351746004583	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
351746004584	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746004585	substrate binding pocket [chemical binding]; other site
351746004586	membrane-bound complex binding site; other site
351746004587	hinge residues; other site
351746004588	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746004589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746004590	dimer interface [polypeptide binding]; other site
351746004591	conserved gate region; other site
351746004592	putative PBP binding loops; other site
351746004593	ABC-ATPase subunit interface; other site
351746004594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746004595	dimer interface [polypeptide binding]; other site
351746004596	conserved gate region; other site
351746004597	putative PBP binding loops; other site
351746004598	ABC-ATPase subunit interface; other site
351746004599	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
351746004600	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746004601	Walker A/P-loop; other site
351746004602	ATP binding site [chemical binding]; other site
351746004603	Q-loop/lid; other site
351746004604	ABC transporter signature motif; other site
351746004605	Walker B; other site
351746004606	D-loop; other site
351746004607	H-loop/switch region; other site
351746004608	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746004609	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
351746004610	conserved cys residue [active]
351746004611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746004612	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746004613	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
351746004614	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746004615	inhibitor-cofactor binding pocket; inhibition site
351746004616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746004617	catalytic residue [active]
351746004618	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
351746004619	arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245
351746004620	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
351746004621	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
351746004622	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
351746004623	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
351746004624	NAD(P) binding site [chemical binding]; other site
351746004625	catalytic residues [active]
351746004626	succinylarginine dihydrolase; Provisional; Region: PRK13281
351746004627	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
351746004628	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
351746004629	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
351746004630	putative active site [active]
351746004631	Zn binding site [ion binding]; other site
351746004632	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
351746004633	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
351746004634	motif 1; other site
351746004635	active site
351746004636	motif 2; other site
351746004637	motif 3; other site
351746004638	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
351746004639	DHHA1 domain; Region: DHHA1; pfam02272
351746004640	aspartate kinase; Reviewed; Region: PRK06635
351746004641	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
351746004642	putative nucleotide binding site [chemical binding]; other site
351746004643	putative catalytic residues [active]
351746004644	putative Mg ion binding site [ion binding]; other site
351746004645	putative aspartate binding site [chemical binding]; other site
351746004646	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
351746004647	putative allosteric regulatory site; other site
351746004648	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
351746004649	putative allosteric regulatory residue; other site
351746004650	carbon storage regulator; Provisional; Region: PRK01712
351746004651	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
351746004652	MgtE intracellular N domain; Region: MgtE_N; smart00924
351746004653	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
351746004654	Divalent cation transporter; Region: MgtE; pfam01769
351746004655	Arc-like DNA binding domain; Region: Arc; pfam03869
351746004656	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
351746004657	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
351746004658	active site
351746004659	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
351746004660	Spore germination protein; Region: Spore_permease; cl17796
351746004661	AAA domain; Region: AAA_32; pfam13654
351746004662	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746004663	PAS fold; Region: PAS_3; pfam08447
351746004664	putative active site [active]
351746004665	heme pocket [chemical binding]; other site
351746004666	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746004667	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746004668	metal binding site [ion binding]; metal-binding site
351746004669	active site
351746004670	I-site; other site
351746004671	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
351746004672	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746004673	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351746004674	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
351746004675	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351746004676	E3 interaction surface; other site
351746004677	lipoyl attachment site [posttranslational modification]; other site
351746004678	e3 binding domain; Region: E3_binding; pfam02817
351746004679	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
351746004680	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
351746004681	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
351746004682	alpha subunit interface [polypeptide binding]; other site
351746004683	TPP binding site [chemical binding]; other site
351746004684	heterodimer interface [polypeptide binding]; other site
351746004685	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351746004686	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
351746004687	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
351746004688	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
351746004689	tetramer interface [polypeptide binding]; other site
351746004690	TPP-binding site [chemical binding]; other site
351746004691	heterodimer interface [polypeptide binding]; other site
351746004692	phosphorylation loop region [posttranslational modification]
351746004693	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746004694	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
351746004695	putative DNA binding site [nucleotide binding]; other site
351746004696	putative Zn2+ binding site [ion binding]; other site
351746004697	AsnC family; Region: AsnC_trans_reg; pfam01037
351746004698	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746004699	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746004700	putative MFS family transporter protein; Provisional; Region: PRK03633
351746004701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746004702	putative substrate translocation pore; other site
351746004703	Flagellar regulator YcgR; Region: YcgR; pfam07317
351746004704	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
351746004705	PilZ domain; Region: PilZ; pfam07238
351746004706	FlgN protein; Region: FlgN; pfam05130
351746004707	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
351746004708	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
351746004709	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
351746004710	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351746004711	Response regulator receiver domain; Region: Response_reg; pfam00072
351746004712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004713	active site
351746004714	phosphorylation site [posttranslational modification]
351746004715	intermolecular recognition site; other site
351746004716	dimerization interface [polypeptide binding]; other site
351746004717	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
351746004718	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
351746004719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746004720	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
351746004721	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
351746004722	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
351746004723	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351746004724	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351746004725	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
351746004726	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
351746004727	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
351746004728	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351746004729	flagellar hook protein FlgE; Validated; Region: flgE; PRK05841
351746004730	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
351746004731	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
351746004732	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351746004733	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
351746004734	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351746004735	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
351746004736	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
351746004737	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351746004738	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351746004739	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
351746004740	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
351746004741	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
351746004742	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
351746004743	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
351746004744	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
351746004745	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
351746004746	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
351746004747	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351746004748	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
351746004749	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
351746004750	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
351746004751	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
351746004752	active site
351746004753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351746004754	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746004755	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351746004756	active site
351746004757	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746004758	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
351746004759	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351746004760	active site
351746004761	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
351746004762	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
351746004763	substrate binding site; other site
351746004764	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
351746004765	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
351746004766	NAD binding site [chemical binding]; other site
351746004767	homotetramer interface [polypeptide binding]; other site
351746004768	homodimer interface [polypeptide binding]; other site
351746004769	substrate binding site [chemical binding]; other site
351746004770	active site
351746004771	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
351746004772	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
351746004773	inhibitor-cofactor binding pocket; inhibition site
351746004774	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746004775	catalytic residue [active]
351746004776	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
351746004777	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
351746004778	Probable Catalytic site; other site
351746004779	metal-binding site
351746004780	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
351746004781	NeuB family; Region: NeuB; pfam03102
351746004782	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
351746004783	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746004784	PYR/PP interface [polypeptide binding]; other site
351746004785	dimer interface [polypeptide binding]; other site
351746004786	TPP binding site [chemical binding]; other site
351746004787	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746004788	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
351746004789	TPP-binding site [chemical binding]; other site
351746004790	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
351746004791	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
351746004792	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746004793	NAD(P) binding site [chemical binding]; other site
351746004794	active site
351746004795	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351746004796	Methyltransferase domain; Region: Methyltransf_12; pfam08242
351746004797	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
351746004798	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
351746004799	dimer interface [polypeptide binding]; other site
351746004800	active site
351746004801	CoA binding pocket [chemical binding]; other site
351746004802	flagellin; Provisional; Region: PRK12802
351746004803	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
351746004804	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
351746004805	FlaG protein; Region: FlaG; pfam03646
351746004806	flagellar capping protein; Reviewed; Region: fliD; PRK08032
351746004807	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
351746004808	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
351746004809	flagellar protein FliS; Validated; Region: fliS; PRK05685
351746004810	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746004811	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
351746004812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746004813	Walker A motif; other site
351746004814	ATP binding site [chemical binding]; other site
351746004815	Walker B motif; other site
351746004816	arginine finger; other site
351746004817	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746004818	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351746004819	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746004820	putative active site [active]
351746004821	heme pocket [chemical binding]; other site
351746004822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746004823	dimer interface [polypeptide binding]; other site
351746004824	phosphorylation site [posttranslational modification]
351746004825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746004826	ATP binding site [chemical binding]; other site
351746004827	Mg2+ binding site [ion binding]; other site
351746004828	G-X-G motif; other site
351746004829	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746004830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004831	active site
351746004832	phosphorylation site [posttranslational modification]
351746004833	intermolecular recognition site; other site
351746004834	dimerization interface [polypeptide binding]; other site
351746004835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746004836	Walker A motif; other site
351746004837	ATP binding site [chemical binding]; other site
351746004838	Walker B motif; other site
351746004839	arginine finger; other site
351746004840	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
351746004841	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
351746004842	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
351746004843	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
351746004844	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
351746004845	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
351746004846	MgtE intracellular N domain; Region: MgtE_N; smart00924
351746004847	FliG C-terminal domain; Region: FliG_C; pfam01706
351746004848	flagellar assembly protein H; Validated; Region: fliH; PRK05687
351746004849	Flagellar assembly protein FliH; Region: FliH; pfam02108
351746004850	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
351746004851	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
351746004852	Walker A motif/ATP binding site; other site
351746004853	Walker B motif; other site
351746004854	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
351746004855	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
351746004856	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
351746004857	anti sigma factor interaction site; other site
351746004858	regulatory phosphorylation site [posttranslational modification]; other site
351746004859	Response regulator receiver domain; Region: Response_reg; pfam00072
351746004860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004861	active site
351746004862	phosphorylation site [posttranslational modification]
351746004863	intermolecular recognition site; other site
351746004864	dimerization interface [polypeptide binding]; other site
351746004865	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
351746004866	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
351746004867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
351746004868	ATP binding site [chemical binding]; other site
351746004869	Mg2+ binding site [ion binding]; other site
351746004870	G-X-G motif; other site
351746004871	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746004872	putative binding surface; other site
351746004873	active site
351746004874	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
351746004875	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
351746004876	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
351746004877	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
351746004878	flagellar motor switch protein; Validated; Region: fliN; PRK05698
351746004879	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
351746004880	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
351746004881	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
351746004882	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
351746004883	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
351746004884	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
351746004885	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
351746004886	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
351746004887	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
351746004888	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
351746004889	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351746004890	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
351746004891	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
351746004892	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746004893	catalytic residue [active]
351746004894	cystathionine beta-lyase; Provisional; Region: PRK07050
351746004895	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746004896	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746004897	catalytic residue [active]
351746004898	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
351746004899	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
351746004900	B12 binding site [chemical binding]; other site
351746004901	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
351746004902	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
351746004903	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351746004904	Transcriptional regulators [Transcription]; Region: GntR; COG1802
351746004905	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746004906	DNA-binding site [nucleotide binding]; DNA binding site
351746004907	FCD domain; Region: FCD; pfam07729
351746004908	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
351746004909	FHIPEP family; Region: FHIPEP; pfam00771
351746004910	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
351746004911	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351746004912	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
351746004913	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351746004914	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351746004915	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
351746004916	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
351746004917	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746004918	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351746004919	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746004920	DNA binding residues [nucleotide binding]
351746004921	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
351746004922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004923	active site
351746004924	phosphorylation site [posttranslational modification]
351746004925	intermolecular recognition site; other site
351746004926	dimerization interface [polypeptide binding]; other site
351746004927	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
351746004928	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746004929	putative binding surface; other site
351746004930	active site
351746004931	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
351746004932	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
351746004933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746004934	ATP binding site [chemical binding]; other site
351746004935	Mg2+ binding site [ion binding]; other site
351746004936	G-X-G motif; other site
351746004937	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
351746004938	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
351746004939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746004940	active site
351746004941	phosphorylation site [posttranslational modification]
351746004942	intermolecular recognition site; other site
351746004943	dimerization interface [polypeptide binding]; other site
351746004944	CheB methylesterase; Region: CheB_methylest; pfam01339
351746004945	flagellar motor protein; Reviewed; Region: motC; PRK09109
351746004946	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
351746004947	flagellar motor protein MotD; Reviewed; Region: PRK09038
351746004948	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
351746004949	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746004950	ligand binding site [chemical binding]; other site
351746004951	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
351746004952	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351746004953	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746004954	Magnesium ion binding site [ion binding]; other site
351746004955	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
351746004956	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
351746004957	putative CheA interaction surface; other site
351746004958	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
351746004959	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
351746004960	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
351746004961	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
351746004962	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
351746004963	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
351746004964	Walker A/P-loop; other site
351746004965	ATP binding site [chemical binding]; other site
351746004966	Q-loop/lid; other site
351746004967	ABC transporter signature motif; other site
351746004968	Walker B; other site
351746004969	D-loop; other site
351746004970	H-loop/switch region; other site
351746004971	heme exporter protein CcmB; Region: ccmB; TIGR01190
351746004972	heme exporter protein CcmC; Region: ccmC; TIGR01191
351746004973	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
351746004974	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
351746004975	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
351746004976	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
351746004977	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746004978	catalytic residues [active]
351746004979	central insert; other site
351746004980	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
351746004981	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
351746004982	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
351746004983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746004984	binding surface
351746004985	TPR motif; other site
351746004986	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
351746004987	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
351746004988	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
351746004989	NAD binding site [chemical binding]; other site
351746004990	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
351746004991	Uncharacterized conserved protein [Function unknown]; Region: COG3791
351746004992	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
351746004993	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746004994	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
351746004995	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746004996	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
351746004997	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
351746004998	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
351746004999	Na binding site [ion binding]; other site
351746005000	putative substrate binding site [chemical binding]; other site
351746005001	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746005002	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
351746005003	AsnC family; Region: AsnC_trans_reg; pfam01037
351746005004	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351746005005	EamA-like transporter family; Region: EamA; pfam00892
351746005006	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
351746005007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746005008	S-adenosylmethionine binding site [chemical binding]; other site
351746005009	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
351746005010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746005011	peptide synthase; Validated; Region: PRK05691
351746005012	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
351746005013	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351746005014	Ion transport protein; Region: Ion_trans; pfam00520
351746005015	Ion channel; Region: Ion_trans_2; pfam07885
351746005016	Double zinc ribbon; Region: DZR; pfam12773
351746005017	Urea transporter; Region: UT; pfam03253
351746005018	pyruvate kinase; Provisional; Region: PRK06247
351746005019	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
351746005020	domain interfaces; other site
351746005021	active site
351746005022	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
351746005023	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
351746005024	MOFRL family; Region: MOFRL; pfam05161
351746005025	tartronate semialdehyde reductase; Provisional; Region: PRK15059
351746005026	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
351746005027	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
351746005028	glyoxylate carboligase; Provisional; Region: PRK11269
351746005029	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746005030	PYR/PP interface [polypeptide binding]; other site
351746005031	dimer interface [polypeptide binding]; other site
351746005032	TPP binding site [chemical binding]; other site
351746005033	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746005034	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
351746005035	TPP-binding site [chemical binding]; other site
351746005036	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
351746005037	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
351746005038	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746005039	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
351746005040	Protein of unknown function (DUF808); Region: DUF808; pfam05661
351746005041	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
351746005042	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
351746005043	xanthine permease; Region: pbuX; TIGR03173
351746005044	Predicted membrane protein [Function unknown]; Region: COG3748
351746005045	Protein of unknown function (DUF989); Region: DUF989; pfam06181
351746005046	Cytochrome c; Region: Cytochrom_C; pfam00034
351746005047	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
351746005048	ureidoglycolate hydrolase; Provisional; Region: PRK03606
351746005049	OHCU decarboxylase; Region: UHCUDC; TIGR03164
351746005050	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
351746005051	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
351746005052	active site
351746005053	catalytic site [active]
351746005054	tetramer interface [polypeptide binding]; other site
351746005055	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
351746005056	active site
351746005057	homotetramer interface [polypeptide binding]; other site
351746005058	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
351746005059	Transcriptional regulators [Transcription]; Region: GntR; COG1802
351746005060	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746005061	DNA-binding site [nucleotide binding]; DNA binding site
351746005062	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746005063	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
351746005064	amphipathic channel; other site
351746005065	Asn-Pro-Ala signature motifs; other site
351746005066	guanine deaminase; Provisional; Region: PRK09228
351746005067	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
351746005068	active site
351746005069	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
351746005070	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
351746005071	XdhC Rossmann domain; Region: XdhC_C; pfam13478
351746005072	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
351746005073	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
351746005074	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746005075	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
351746005076	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746005077	catalytic loop [active]
351746005078	iron binding site [ion binding]; other site
351746005079	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
351746005080	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
351746005081	Transcriptional regulators [Transcription]; Region: GntR; COG1802
351746005082	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746005083	DNA-binding site [nucleotide binding]; DNA binding site
351746005084	FCD domain; Region: FCD; cl11656
351746005085	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
351746005086	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
351746005087	Walker A/P-loop; other site
351746005088	ATP binding site [chemical binding]; other site
351746005089	Q-loop/lid; other site
351746005090	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
351746005091	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
351746005092	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
351746005093	ABC transporter signature motif; other site
351746005094	Walker B; other site
351746005095	D-loop; other site
351746005096	H-loop/switch region; other site
351746005097	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
351746005098	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
351746005099	FtsZ protein binding site [polypeptide binding]; other site
351746005100	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
351746005101	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
351746005102	nucleotide binding pocket [chemical binding]; other site
351746005103	K-X-D-G motif; other site
351746005104	catalytic site [active]
351746005105	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
351746005106	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
351746005107	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
351746005108	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
351746005109	Dimer interface [polypeptide binding]; other site
351746005110	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
351746005111	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
351746005112	DNA binding residues [nucleotide binding]
351746005113	putative dimer interface [polypeptide binding]; other site
351746005114	putative metal binding residues [ion binding]; other site
351746005115	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
351746005116	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746005117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746005118	substrate binding pocket [chemical binding]; other site
351746005119	membrane-bound complex binding site; other site
351746005120	hinge residues; other site
351746005121	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
351746005122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746005123	Walker A motif; other site
351746005124	ATP binding site [chemical binding]; other site
351746005125	Walker B motif; other site
351746005126	arginine finger; other site
351746005127	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
351746005128	hypothetical protein; Validated; Region: PRK00153
351746005129	recombination protein RecR; Reviewed; Region: recR; PRK00076
351746005130	RecR protein; Region: RecR; pfam02132
351746005131	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
351746005132	putative active site [active]
351746005133	putative metal-binding site [ion binding]; other site
351746005134	tetramer interface [polypeptide binding]; other site
351746005135	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746005136	active site
351746005137	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
351746005138	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351746005139	ligand binding site [chemical binding]; other site
351746005140	flexible hinge region; other site
351746005141	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
351746005142	putative switch regulator; other site
351746005143	non-specific DNA interactions [nucleotide binding]; other site
351746005144	DNA binding site [nucleotide binding]
351746005145	sequence specific DNA binding site [nucleotide binding]; other site
351746005146	putative cAMP binding site [chemical binding]; other site
351746005147	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
351746005148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746005149	FeS/SAM binding site; other site
351746005150	HemN C-terminal domain; Region: HemN_C; pfam06969
351746005151	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
351746005152	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
351746005153	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
351746005154	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351746005155	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351746005156	metal-binding site [ion binding]
351746005157	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746005158	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351746005159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
351746005160	FixH; Region: FixH; pfam05751
351746005161	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
351746005162	4Fe-4S binding domain; Region: Fer4_5; pfam12801
351746005163	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
351746005164	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
351746005165	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746005166	Cytochrome c; Region: Cytochrom_C; pfam00034
351746005167	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
351746005168	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
351746005169	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
351746005170	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
351746005171	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
351746005172	Low-spin heme binding site [chemical binding]; other site
351746005173	Putative water exit pathway; other site
351746005174	Binuclear center (active site) [active]
351746005175	Putative proton exit pathway; other site
351746005176	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
351746005177	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746005178	Cytochrome c; Region: Cytochrom_C; pfam00034
351746005179	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
351746005180	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
351746005181	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
351746005182	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
351746005183	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
351746005184	Low-spin heme binding site [chemical binding]; other site
351746005185	Putative water exit pathway; other site
351746005186	Binuclear center (active site) [active]
351746005187	Putative proton exit pathway; other site
351746005188	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
351746005189	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
351746005190	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
351746005191	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
351746005192	active site
351746005193	catalytic site [active]
351746005194	substrate binding site [chemical binding]; other site
351746005195	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
351746005196	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746005197	substrate binding pocket [chemical binding]; other site
351746005198	membrane-bound complex binding site; other site
351746005199	hinge residues; other site
351746005200	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
351746005201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746005202	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746005203	DNA binding residues [nucleotide binding]
351746005204	peptide synthase; Validated; Region: PRK05691
351746005205	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
351746005206	acyl-activating enzyme (AAE) consensus motif; other site
351746005207	active site
351746005208	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005209	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005210	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005211	acyl-activating enzyme (AAE) consensus motif; other site
351746005212	AMP binding site [chemical binding]; other site
351746005213	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005214	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005215	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005216	acyl-activating enzyme (AAE) consensus motif; other site
351746005217	AMP binding site [chemical binding]; other site
351746005218	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005219	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
351746005220	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005221	acyl-activating enzyme (AAE) consensus motif; other site
351746005222	AMP binding site [chemical binding]; other site
351746005223	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005224	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746005225	D-loop; other site
351746005226	H-loop/switch region; other site
351746005227	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
351746005228	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
351746005229	dimerization domain [polypeptide binding]; other site
351746005230	dimer interface [polypeptide binding]; other site
351746005231	catalytic residues [active]
351746005232	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
351746005233	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
351746005234	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746005235	catalytic residues [active]
351746005236	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
351746005237	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
351746005238	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
351746005239	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746005240	DsbD alpha interface [polypeptide binding]; other site
351746005241	catalytic residues [active]
351746005242	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
351746005243	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746005244	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
351746005245	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746005246	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
351746005247	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
351746005248	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
351746005249	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746005250	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746005251	Cytochrome c; Region: Cytochrom_C; pfam00034
351746005252	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
351746005253	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
351746005254	XdhC Rossmann domain; Region: XdhC_C; pfam13478
351746005255	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
351746005256	metal-binding site
351746005257	GAD-like domain; Region: GAD-like; pfam08887
351746005258	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
351746005259	GAD-like domain; Region: GAD-like; pfam08887
351746005260	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
351746005261	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746005262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746005263	active site
351746005264	phosphorylation site [posttranslational modification]
351746005265	intermolecular recognition site; other site
351746005266	dimerization interface [polypeptide binding]; other site
351746005267	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746005268	DNA binding site [nucleotide binding]
351746005269	sensor protein QseC; Provisional; Region: PRK10337
351746005270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746005271	dimer interface [polypeptide binding]; other site
351746005272	phosphorylation site [posttranslational modification]
351746005273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746005274	ATP binding site [chemical binding]; other site
351746005275	G-X-G motif; other site
351746005276	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
351746005277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746005278	inhibitor-cofactor binding pocket; inhibition site
351746005279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746005280	catalytic residue [active]
351746005281	SCP-2 sterol transfer family; Region: SCP2; pfam02036
351746005282	Cupin-like domain; Region: Cupin_8; pfam13621
351746005283	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
351746005284	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746005285	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746005286	catalytic residue [active]
351746005287	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
351746005288	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
351746005289	active site
351746005290	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
351746005291	RNA polymerase sigma factor; Reviewed; Region: PRK12527
351746005292	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746005293	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746005294	DNA binding residues [nucleotide binding]
351746005295	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
351746005296	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746005297	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
351746005298	peptide binding site [polypeptide binding]; other site
351746005299	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
351746005300	toxin interface [polypeptide binding]; other site
351746005301	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
351746005302	Zn binding site [ion binding]; other site
351746005303	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
351746005304	non-specific DNA binding site [nucleotide binding]; other site
351746005305	salt bridge; other site
351746005306	sequence-specific DNA binding site [nucleotide binding]; other site
351746005307	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
351746005308	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746005309	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
351746005310	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
351746005311	Ligand binding site [chemical binding]; other site
351746005312	Electron transfer flavoprotein domain; Region: ETF; pfam01012
351746005313	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
351746005314	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
351746005315	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
351746005316	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746005317	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746005318	substrate binding pocket [chemical binding]; other site
351746005319	membrane-bound complex binding site; other site
351746005320	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
351746005321	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746005322	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746005323	ligand binding site [chemical binding]; other site
351746005324	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746005325	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746005326	DNA-binding site [nucleotide binding]; DNA binding site
351746005327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746005328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746005329	homodimer interface [polypeptide binding]; other site
351746005330	catalytic residue [active]
351746005331	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
351746005332	putative lipid binding site [chemical binding]; other site
351746005333	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
351746005334	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
351746005335	dimer interface [polypeptide binding]; other site
351746005336	active site
351746005337	citrylCoA binding site [chemical binding]; other site
351746005338	NADH binding [chemical binding]; other site
351746005339	cationic pore residues; other site
351746005340	oxalacetate/citrate binding site [chemical binding]; other site
351746005341	coenzyme A binding site [chemical binding]; other site
351746005342	catalytic triad [active]
351746005343	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
351746005344	Iron-sulfur protein interface; other site
351746005345	proximal quinone binding site [chemical binding]; other site
351746005346	SdhD (CybS) interface [polypeptide binding]; other site
351746005347	proximal heme binding site [chemical binding]; other site
351746005348	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
351746005349	SdhC subunit interface [polypeptide binding]; other site
351746005350	proximal heme binding site [chemical binding]; other site
351746005351	cardiolipin binding site; other site
351746005352	Iron-sulfur protein interface; other site
351746005353	proximal quinone binding site [chemical binding]; other site
351746005354	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
351746005355	L-aspartate oxidase; Provisional; Region: PRK06175
351746005356	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
351746005357	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
351746005358	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
351746005359	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
351746005360	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
351746005361	TPP-binding site [chemical binding]; other site
351746005362	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
351746005363	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
351746005364	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351746005365	E3 interaction surface; other site
351746005366	lipoyl attachment site [posttranslational modification]; other site
351746005367	e3 binding domain; Region: E3_binding; pfam02817
351746005368	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
351746005369	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
351746005370	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
351746005371	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746005372	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351746005373	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
351746005374	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
351746005375	CoA-ligase; Region: Ligase_CoA; pfam00549
351746005376	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
351746005377	CoA binding domain; Region: CoA_binding; pfam02629
351746005378	CoA-ligase; Region: Ligase_CoA; pfam00549
351746005379	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
351746005380	Predicted membrane protein [Function unknown]; Region: COG3821
351746005381	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
351746005382	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
351746005383	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
351746005384	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
351746005385	peptide synthase; Provisional; Region: PRK12467
351746005386	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005387	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005388	acyl-activating enzyme (AAE) consensus motif; other site
351746005389	AMP binding site [chemical binding]; other site
351746005390	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005391	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005392	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005393	acyl-activating enzyme (AAE) consensus motif; other site
351746005394	AMP binding site [chemical binding]; other site
351746005395	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005396	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
351746005397	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005398	acyl-activating enzyme (AAE) consensus motif; other site
351746005399	AMP binding site [chemical binding]; other site
351746005400	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005401	Condensation domain; Region: Condensation; pfam00668
351746005402	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005403	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
351746005404	Condensation domain; Region: Condensation; pfam00668
351746005405	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005406	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005407	acyl-activating enzyme (AAE) consensus motif; other site
351746005408	AMP binding site [chemical binding]; other site
351746005409	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005410	Condensation domain; Region: Condensation; pfam00668
351746005411	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005412	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005413	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
351746005414	acyl-activating enzyme (AAE) consensus motif; other site
351746005415	AMP binding site [chemical binding]; other site
351746005416	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005417	Condensation domain; Region: Condensation; pfam00668
351746005418	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005419	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005420	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005421	acyl-activating enzyme (AAE) consensus motif; other site
351746005422	AMP binding site [chemical binding]; other site
351746005423	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005424	Condensation domain; Region: Condensation; pfam00668
351746005425	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005426	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
351746005427	Condensation domain; Region: Condensation; pfam00668
351746005428	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005429	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005430	acyl-activating enzyme (AAE) consensus motif; other site
351746005431	AMP binding site [chemical binding]; other site
351746005432	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005433	Condensation domain; Region: Condensation; pfam00668
351746005434	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
351746005435	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005436	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
351746005437	Condensation domain; Region: Condensation; pfam00668
351746005438	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005439	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
351746005440	acyl-activating enzyme (AAE) consensus motif; other site
351746005441	AMP binding site [chemical binding]; other site
351746005442	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005443	Secretin and TonB N terminus short domain; Region: STN; pfam07660
351746005444	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
351746005445	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746005446	N-terminal plug; other site
351746005447	ligand-binding site [chemical binding]; other site
351746005448	Uncharacterized conserved protein [Function unknown]; Region: COG1262
351746005449	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
351746005450	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
351746005451	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
351746005452	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746005453	acyl-activating enzyme (AAE) consensus motif; other site
351746005454	AMP binding site [chemical binding]; other site
351746005455	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746005456	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
351746005457	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746005458	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
351746005459	Walker A/P-loop; other site
351746005460	ATP binding site [chemical binding]; other site
351746005461	Q-loop/lid; other site
351746005462	ABC transporter signature motif; other site
351746005463	Walker B; other site
351746005464	D-loop; other site
351746005465	H-loop/switch region; other site
351746005466	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
351746005467	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
351746005468	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
351746005469	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
351746005470	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351746005471	Walker A/P-loop; other site
351746005472	ATP binding site [chemical binding]; other site
351746005473	Q-loop/lid; other site
351746005474	ABC transporter signature motif; other site
351746005475	Walker B; other site
351746005476	D-loop; other site
351746005477	H-loop/switch region; other site
351746005478	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351746005479	FtsX-like permease family; Region: FtsX; pfam02687
351746005480	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746005481	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746005482	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
351746005483	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746005484	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
351746005485	CoenzymeA binding site [chemical binding]; other site
351746005486	subunit interaction site [polypeptide binding]; other site
351746005487	PHB binding site; other site
351746005488	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
351746005489	CoenzymeA binding site [chemical binding]; other site
351746005490	subunit interaction site [polypeptide binding]; other site
351746005491	PHB binding site; other site
351746005492	heat shock protein 90; Provisional; Region: PRK05218
351746005493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746005494	ATP binding site [chemical binding]; other site
351746005495	Mg2+ binding site [ion binding]; other site
351746005496	G-X-G motif; other site
351746005497	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
351746005498	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746005499	Pirin-related protein [General function prediction only]; Region: COG1741
351746005500	Pirin; Region: Pirin; pfam02678
351746005501	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
351746005502	Amidohydrolase; Region: Amidohydro_2; pfam04909
351746005503	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
351746005504	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
351746005505	dimer interface [polypeptide binding]; other site
351746005506	active site
351746005507	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
351746005508	active site 1 [active]
351746005509	dimer interface [polypeptide binding]; other site
351746005510	active site 2 [active]
351746005511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746005512	dimerization interface [polypeptide binding]; other site
351746005513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746005514	dimer interface [polypeptide binding]; other site
351746005515	phosphorylation site [posttranslational modification]
351746005516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746005517	ATP binding site [chemical binding]; other site
351746005518	Mg2+ binding site [ion binding]; other site
351746005519	G-X-G motif; other site
351746005520	Response regulator receiver domain; Region: Response_reg; pfam00072
351746005521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746005522	active site
351746005523	phosphorylation site [posttranslational modification]
351746005524	intermolecular recognition site; other site
351746005525	dimerization interface [polypeptide binding]; other site
351746005526	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
351746005527	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746005528	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
351746005529	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
351746005530	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
351746005531	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
351746005532	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
351746005533	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
351746005534	catalytic core [active]
351746005535	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746005536	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746005537	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
351746005538	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
351746005539	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
351746005540	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746005541	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
351746005542	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351746005543	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
351746005544	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
351746005545	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
351746005546	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
351746005547	Ligand Binding Site [chemical binding]; other site
351746005548	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
351746005549	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746005550	dimer interface [polypeptide binding]; other site
351746005551	phosphorylation site [posttranslational modification]
351746005552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746005553	ATP binding site [chemical binding]; other site
351746005554	Mg2+ binding site [ion binding]; other site
351746005555	G-X-G motif; other site
351746005556	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
351746005557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746005558	active site
351746005559	phosphorylation site [posttranslational modification]
351746005560	intermolecular recognition site; other site
351746005561	dimerization interface [polypeptide binding]; other site
351746005562	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746005563	DNA binding site [nucleotide binding]
351746005564	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746005565	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746005566	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746005567	dimerization interface [polypeptide binding]; other site
351746005568	hypothetical protein; Provisional; Region: PRK06149
351746005569	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
351746005570	active site
351746005571	ATP binding site [chemical binding]; other site
351746005572	substrate binding site [chemical binding]; other site
351746005573	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746005574	inhibitor-cofactor binding pocket; inhibition site
351746005575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746005576	catalytic residue [active]
351746005577	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746005578	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746005579	N-terminal plug; other site
351746005580	ligand-binding site [chemical binding]; other site
351746005581	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
351746005582	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351746005583	Walker A/P-loop; other site
351746005584	ATP binding site [chemical binding]; other site
351746005585	Q-loop/lid; other site
351746005586	ABC transporter signature motif; other site
351746005587	Walker B; other site
351746005588	D-loop; other site
351746005589	H-loop/switch region; other site
351746005590	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
351746005591	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351746005592	Walker A/P-loop; other site
351746005593	ATP binding site [chemical binding]; other site
351746005594	Q-loop/lid; other site
351746005595	ABC transporter signature motif; other site
351746005596	Walker B; other site
351746005597	D-loop; other site
351746005598	H-loop/switch region; other site
351746005599	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
351746005600	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
351746005601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746005602	dimer interface [polypeptide binding]; other site
351746005603	conserved gate region; other site
351746005604	putative PBP binding loops; other site
351746005605	ABC-ATPase subunit interface; other site
351746005606	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
351746005607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746005608	dimer interface [polypeptide binding]; other site
351746005609	conserved gate region; other site
351746005610	putative PBP binding loops; other site
351746005611	ABC-ATPase subunit interface; other site
351746005612	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
351746005613	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
351746005614	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
351746005615	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
351746005616	MltD lipid attachment motif; Region: MLTD_N; pfam06474
351746005617	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
351746005618	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746005619	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746005620	catalytic residue [active]
351746005621	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351746005622	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351746005623	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
351746005624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746005625	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
351746005626	RNA/DNA hybrid binding site [nucleotide binding]; other site
351746005627	active site
351746005628	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
351746005629	active site
351746005630	catalytic site [active]
351746005631	substrate binding site [chemical binding]; other site
351746005632	arginine decarboxylase; Provisional; Region: PRK15029
351746005633	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
351746005634	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
351746005635	homodimer interface [polypeptide binding]; other site
351746005636	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746005637	catalytic residue [active]
351746005638	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
351746005639	Predicted flavoprotein [General function prediction only]; Region: COG0431
351746005640	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746005641	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
351746005642	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
351746005643	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746005644	DNA binding residues [nucleotide binding]
351746005645	dimerization interface [polypeptide binding]; other site
351746005646	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
351746005647	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
351746005648	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
351746005649	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
351746005650	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
351746005651	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
351746005652	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
351746005653	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
351746005654	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
351746005655	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
351746005656	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
351746005657	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
351746005658	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
351746005659	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
351746005660	4Fe-4S binding domain; Region: Fer4; pfam00037
351746005661	4Fe-4S binding domain; Region: Fer4; pfam00037
351746005662	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
351746005663	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
351746005664	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746005665	catalytic loop [active]
351746005666	iron binding site [ion binding]; other site
351746005667	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
351746005668	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
351746005669	[4Fe-4S] binding site [ion binding]; other site
351746005670	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
351746005671	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
351746005672	SLBB domain; Region: SLBB; pfam10531
351746005673	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
351746005674	NADH dehydrogenase subunit E; Validated; Region: PRK07539
351746005675	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
351746005676	putative dimer interface [polypeptide binding]; other site
351746005677	[2Fe-2S] cluster binding site [ion binding]; other site
351746005678	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
351746005679	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
351746005680	NADH dehydrogenase subunit D; Validated; Region: PRK06075
351746005681	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
351746005682	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
351746005683	YhhN-like protein; Region: YhhN; pfam07947
351746005684	isocitrate lyase; Provisional; Region: PRK15063
351746005685	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
351746005686	tetramer interface [polypeptide binding]; other site
351746005687	active site
351746005688	Mg2+/Mn2+ binding site [ion binding]; other site
351746005689	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
351746005690	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
351746005691	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
351746005692	active site
351746005693	catalytic residues [active]
351746005694	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
351746005695	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
351746005696	Sulfate transporter family; Region: Sulfate_transp; pfam00916
351746005697	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
351746005698	elongation factor G; Reviewed; Region: PRK00007
351746005699	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
351746005700	G1 box; other site
351746005701	putative GEF interaction site [polypeptide binding]; other site
351746005702	GTP/Mg2+ binding site [chemical binding]; other site
351746005703	Switch I region; other site
351746005704	G2 box; other site
351746005705	G3 box; other site
351746005706	Switch II region; other site
351746005707	G4 box; other site
351746005708	G5 box; other site
351746005709	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
351746005710	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
351746005711	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
351746005712	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
351746005713	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746005714	inhibitor-cofactor binding pocket; inhibition site
351746005715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746005716	catalytic residue [active]
351746005717	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746005718	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746005719	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
351746005720	dimerization interface [polypeptide binding]; other site
351746005721	substrate binding pocket [chemical binding]; other site
351746005722	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
351746005723	Spore germination protein; Region: Spore_permease; cl17796
351746005724	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
351746005725	CoenzymeA binding site [chemical binding]; other site
351746005726	subunit interaction site [polypeptide binding]; other site
351746005727	PHB binding site; other site
351746005728	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746005729	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
351746005730	C-terminal domain interface [polypeptide binding]; other site
351746005731	GSH binding site (G-site) [chemical binding]; other site
351746005732	dimer interface [polypeptide binding]; other site
351746005733	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
351746005734	dimer interface [polypeptide binding]; other site
351746005735	N-terminal domain interface [polypeptide binding]; other site
351746005736	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
351746005737	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
351746005738	Uncharacterized conserved protein [Function unknown]; Region: COG3189
351746005739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746005740	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
351746005741	Coenzyme A binding pocket [chemical binding]; other site
351746005742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
351746005743	sequence-specific DNA binding site [nucleotide binding]; other site
351746005744	salt bridge; other site
351746005745	response regulator; Provisional; Region: PRK09483
351746005746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746005747	active site
351746005748	phosphorylation site [posttranslational modification]
351746005749	intermolecular recognition site; other site
351746005750	dimerization interface [polypeptide binding]; other site
351746005751	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746005752	DNA binding residues [nucleotide binding]
351746005753	dimerization interface [polypeptide binding]; other site
351746005754	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
351746005755	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
351746005756	GIY-YIG motif/motif A; other site
351746005757	active site
351746005758	catalytic site [active]
351746005759	putative DNA binding site [nucleotide binding]; other site
351746005760	metal binding site [ion binding]; metal-binding site
351746005761	UvrB/uvrC motif; Region: UVR; pfam02151
351746005762	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
351746005763	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
351746005764	DNA binding site [nucleotide binding]
351746005765	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
351746005766	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
351746005767	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
351746005768	catalytic residues [active]
351746005769	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
351746005770	DNA binding residues [nucleotide binding]
351746005771	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
351746005772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746005773	non-specific DNA binding site [nucleotide binding]; other site
351746005774	salt bridge; other site
351746005775	sequence-specific DNA binding site [nucleotide binding]; other site
351746005776	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746005777	Catalytic site [active]
351746005778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746005779	non-specific DNA binding site [nucleotide binding]; other site
351746005780	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
351746005781	salt bridge; other site
351746005782	sequence-specific DNA binding site [nucleotide binding]; other site
351746005783	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746005784	Catalytic site [active]
351746005785	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
351746005786	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351746005787	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
351746005788	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
351746005789	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351746005790	carboxyltransferase (CT) interaction site; other site
351746005791	biotinylation site [posttranslational modification]; other site
351746005792	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
351746005793	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746005794	substrate binding site [chemical binding]; other site
351746005795	oxyanion hole (OAH) forming residues; other site
351746005796	trimer interface [polypeptide binding]; other site
351746005797	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
351746005798	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
351746005799	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
351746005800	isovaleryl-CoA dehydrogenase; Region: PLN02519
351746005801	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
351746005802	substrate binding site [chemical binding]; other site
351746005803	FAD binding site [chemical binding]; other site
351746005804	catalytic base [active]
351746005805	AMP-binding domain protein; Validated; Region: PRK08315
351746005806	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746005807	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
351746005808	acyl-activating enzyme (AAE) consensus motif; other site
351746005809	putative AMP binding site [chemical binding]; other site
351746005810	putative active site [active]
351746005811	putative CoA binding site [chemical binding]; other site
351746005812	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746005813	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746005814	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
351746005815	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
351746005816	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
351746005817	active site
351746005818	homodimer interface [polypeptide binding]; other site
351746005819	catalytic site [active]
351746005820	acceptor binding site [chemical binding]; other site
351746005821	trehalose synthase; Region: treS_nterm; TIGR02456
351746005822	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
351746005823	active site
351746005824	catalytic site [active]
351746005825	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
351746005826	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
351746005827	glycogen branching enzyme; Provisional; Region: PRK05402
351746005828	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
351746005829	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
351746005830	active site
351746005831	catalytic site [active]
351746005832	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
351746005833	Autotransporter beta-domain; Region: Autotransporter; smart00869
351746005834	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
351746005835	putative catalytic site [active]
351746005836	putative metal binding site [ion binding]; other site
351746005837	putative phosphate binding site [ion binding]; other site
351746005838	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
351746005839	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
351746005840	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
351746005841	active site
351746005842	catalytic site [active]
351746005843	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
351746005844	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
351746005845	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
351746005846	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
351746005847	active site
351746005848	catalytic site [active]
351746005849	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
351746005850	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
351746005851	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
351746005852	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
351746005853	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
351746005854	catalytic site [active]
351746005855	active site
351746005856	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
351746005857	glycogen synthase; Provisional; Region: glgA; PRK00654
351746005858	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
351746005859	ADP-binding pocket [chemical binding]; other site
351746005860	homodimer interface [polypeptide binding]; other site
351746005861	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
351746005862	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
351746005863	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
351746005864	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
351746005865	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
351746005866	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
351746005867	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
351746005868	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746005869	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
351746005870	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
351746005871	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746005872	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
351746005873	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
351746005874	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
351746005875	homodimer interface [polypeptide binding]; other site
351746005876	active site
351746005877	FMN binding site [chemical binding]; other site
351746005878	substrate binding site [chemical binding]; other site
351746005879	4Fe-4S binding domain; Region: Fer4_6; pfam12837
351746005880	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
351746005881	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351746005882	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746005883	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746005884	phenylhydantoinase; Validated; Region: PRK08323
351746005885	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
351746005886	tetramer interface [polypeptide binding]; other site
351746005887	active site
351746005888	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
351746005889	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
351746005890	Na binding site [ion binding]; other site
351746005891	putative substrate binding site [chemical binding]; other site
351746005892	allantoate amidohydrolase; Reviewed; Region: PRK12893
351746005893	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
351746005894	active site
351746005895	metal binding site [ion binding]; metal-binding site
351746005896	dimer interface [polypeptide binding]; other site
351746005897	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
351746005898	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
351746005899	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
351746005900	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
351746005901	enoyl-CoA hydratase; Provisional; Region: PRK06142
351746005902	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746005903	substrate binding site [chemical binding]; other site
351746005904	oxyanion hole (OAH) forming residues; other site
351746005905	trimer interface [polypeptide binding]; other site
351746005906	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
351746005907	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
351746005908	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
351746005909	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
351746005910	putative NADH binding site [chemical binding]; other site
351746005911	putative active site [active]
351746005912	nudix motif; other site
351746005913	putative metal binding site [ion binding]; other site
351746005914	hypothetical protein; Provisional; Region: PRK10621
351746005915	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746005916	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746005917	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746005918	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746005919	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746005920	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746005921	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746005922	DNA topoisomerase III; Provisional; Region: PRK07726
351746005923	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
351746005924	active site
351746005925	putative interdomain interaction site [polypeptide binding]; other site
351746005926	putative metal-binding site [ion binding]; other site
351746005927	putative nucleotide binding site [chemical binding]; other site
351746005928	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
351746005929	domain I; other site
351746005930	DNA binding groove [nucleotide binding]
351746005931	phosphate binding site [ion binding]; other site
351746005932	domain II; other site
351746005933	domain III; other site
351746005934	nucleotide binding site [chemical binding]; other site
351746005935	catalytic site [active]
351746005936	domain IV; other site
351746005937	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746005938	Coenzyme A binding pocket [chemical binding]; other site
351746005939	Uncharacterized conserved protein [Function unknown]; Region: COG2850
351746005940	Cupin domain; Region: Cupin_2; cl17218
351746005941	adenylosuccinate lyase; Provisional; Region: PRK09285
351746005942	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
351746005943	tetramer interface [polypeptide binding]; other site
351746005944	active site
351746005945	putative lysogenization regulator; Reviewed; Region: PRK00218
351746005946	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
351746005947	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
351746005948	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
351746005949	nudix motif; other site
351746005950	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
351746005951	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
351746005952	isocitrate dehydrogenase; Validated; Region: PRK07362
351746005953	isocitrate dehydrogenase; Reviewed; Region: PRK07006
351746005954	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351746005955	DNA-binding site [nucleotide binding]; DNA binding site
351746005956	RNA-binding motif; other site
351746005957	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
351746005958	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
351746005959	Clp amino terminal domain; Region: Clp_N; pfam02861
351746005960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746005961	Walker A motif; other site
351746005962	ATP binding site [chemical binding]; other site
351746005963	Walker B motif; other site
351746005964	arginine finger; other site
351746005965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746005966	Walker A motif; other site
351746005967	ATP binding site [chemical binding]; other site
351746005968	Walker B motif; other site
351746005969	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
351746005970	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
351746005971	rRNA binding site [nucleotide binding]; other site
351746005972	predicted 30S ribosome binding site; other site
351746005973	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
351746005974	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
351746005975	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
351746005976	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
351746005977	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
351746005978	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
351746005979	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
351746005980	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
351746005981	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
351746005982	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
351746005983	recombination factor protein RarA; Reviewed; Region: PRK13342
351746005984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746005985	Walker A motif; other site
351746005986	ATP binding site [chemical binding]; other site
351746005987	Walker B motif; other site
351746005988	arginine finger; other site
351746005989	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
351746005990	camphor resistance protein CrcB; Provisional; Region: PRK14234
351746005991	seryl-tRNA synthetase; Provisional; Region: PRK05431
351746005992	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
351746005993	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
351746005994	dimer interface [polypeptide binding]; other site
351746005995	active site
351746005996	motif 1; other site
351746005997	motif 2; other site
351746005998	motif 3; other site
351746005999	siroheme synthase; Provisional; Region: cysG; PRK10637
351746006000	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
351746006001	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
351746006002	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
351746006003	active site
351746006004	SAM binding site [chemical binding]; other site
351746006005	homodimer interface [polypeptide binding]; other site
351746006006	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
351746006007	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
351746006008	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
351746006009	putative dimer interface [polypeptide binding]; other site
351746006010	N-terminal domain interface [polypeptide binding]; other site
351746006011	putative substrate binding pocket (H-site) [chemical binding]; other site
351746006012	hypothetical protein; Validated; Region: PRK09071
351746006013	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
351746006014	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
351746006015	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
351746006016	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
351746006017	sulfur relay protein TusC; Validated; Region: PRK00211
351746006018	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
351746006019	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
351746006020	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
351746006021	YccA-like proteins; Region: YccA_like; cd10433
351746006022	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
351746006023	classical (c) SDRs; Region: SDR_c; cd05233
351746006024	NAD(P) binding site [chemical binding]; other site
351746006025	active site
351746006026	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746006027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006028	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746006029	dimerization interface [polypeptide binding]; other site
351746006030	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
351746006031	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
351746006032	dimer interface [polypeptide binding]; other site
351746006033	active site
351746006034	catalytic residue [active]
351746006035	metal binding site [ion binding]; metal-binding site
351746006036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
351746006037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006038	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746006039	putative substrate translocation pore; other site
351746006040	pyruvate kinase; Provisional; Region: PRK05826
351746006041	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
351746006042	domain interfaces; other site
351746006043	active site
351746006044	enolase; Provisional; Region: eno; PRK00077
351746006045	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
351746006046	dimer interface [polypeptide binding]; other site
351746006047	metal binding site [ion binding]; metal-binding site
351746006048	substrate binding pocket [chemical binding]; other site
351746006049	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006050	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006051	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746006052	putative effector binding pocket; other site
351746006053	dimerization interface [polypeptide binding]; other site
351746006054	short chain dehydrogenase; Provisional; Region: PRK06500
351746006055	classical (c) SDRs; Region: SDR_c; cd05233
351746006056	NAD(P) binding site [chemical binding]; other site
351746006057	active site
351746006058	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746006059	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
351746006060	C-terminal domain interface [polypeptide binding]; other site
351746006061	GSH binding site (G-site) [chemical binding]; other site
351746006062	dimer interface [polypeptide binding]; other site
351746006063	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
351746006064	N-terminal domain interface [polypeptide binding]; other site
351746006065	dimer interface [polypeptide binding]; other site
351746006066	substrate binding pocket (H-site) [chemical binding]; other site
351746006067	Flagellin N-methylase; Region: FliB; pfam03692
351746006068	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746006069	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746006070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746006071	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
351746006072	Isochorismatase family; Region: Isochorismatase; pfam00857
351746006073	catalytic triad [active]
351746006074	dimer interface [polypeptide binding]; other site
351746006075	conserved cis-peptide bond; other site
351746006076	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746006077	homotrimer interaction site [polypeptide binding]; other site
351746006078	putative active site [active]
351746006079	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006080	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006081	LysR substrate binding domain; Region: LysR_substrate; pfam03466
351746006082	dimerization interface [polypeptide binding]; other site
351746006083	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
351746006084	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
351746006085	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746006086	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746006087	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
351746006088	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
351746006089	putative ion selectivity filter; other site
351746006090	putative pore gating glutamate residue; other site
351746006091	putative H+/Cl- coupling transport residue; other site
351746006092	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
351746006093	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
351746006094	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
351746006095	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
351746006096	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
351746006097	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746006098	dimer interface [polypeptide binding]; other site
351746006099	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
351746006100	putative CheW interface [polypeptide binding]; other site
351746006101	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
351746006102	NADH(P)-binding; Region: NAD_binding_10; pfam13460
351746006103	extended (e) SDRs; Region: SDR_e; cd08946
351746006104	NAD(P) binding site [chemical binding]; other site
351746006105	active site
351746006106	substrate binding site [chemical binding]; other site
351746006107	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
351746006108	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
351746006109	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
351746006110	putative active site pocket [active]
351746006111	metal binding site [ion binding]; metal-binding site
351746006112	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
351746006113	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
351746006114	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
351746006115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746006116	dimer interface [polypeptide binding]; other site
351746006117	conserved gate region; other site
351746006118	putative PBP binding loops; other site
351746006119	ABC-ATPase subunit interface; other site
351746006120	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
351746006121	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
351746006122	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
351746006123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746006124	dimer interface [polypeptide binding]; other site
351746006125	conserved gate region; other site
351746006126	ABC-ATPase subunit interface; other site
351746006127	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
351746006128	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351746006129	Walker A/P-loop; other site
351746006130	ATP binding site [chemical binding]; other site
351746006131	Q-loop/lid; other site
351746006132	ABC transporter signature motif; other site
351746006133	Walker B; other site
351746006134	D-loop; other site
351746006135	H-loop/switch region; other site
351746006136	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
351746006137	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
351746006138	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351746006139	Walker A/P-loop; other site
351746006140	ATP binding site [chemical binding]; other site
351746006141	Q-loop/lid; other site
351746006142	ABC transporter signature motif; other site
351746006143	Walker B; other site
351746006144	D-loop; other site
351746006145	H-loop/switch region; other site
351746006146	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
351746006147	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
351746006148	Interdomain contacts; other site
351746006149	Cytokine receptor motif; other site
351746006150	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
351746006151	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746006152	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006153	DNA-binding site [nucleotide binding]; DNA binding site
351746006154	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746006155	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746006156	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006157	DNA-binding site [nucleotide binding]; DNA binding site
351746006158	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746006159	XdhC Rossmann domain; Region: XdhC_C; pfam13478
351746006160	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
351746006161	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746006162	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746006163	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
351746006164	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
351746006165	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746006166	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746006167	Cytochrome c; Region: Cytochrom_C; pfam00034
351746006168	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746006169	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746006170	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746006171	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
351746006172	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
351746006173	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
351746006174	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351746006175	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
351746006176	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
351746006177	hypothetical protein; Provisional; Region: PRK06847
351746006178	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
351746006179	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746006180	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
351746006181	Isochorismatase family; Region: Isochorismatase; pfam00857
351746006182	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
351746006183	catalytic triad [active]
351746006184	substrate binding site [chemical binding]; other site
351746006185	domain interfaces; other site
351746006186	conserved cis-peptide bond; other site
351746006187	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
351746006188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006189	putative substrate translocation pore; other site
351746006190	outer membrane porin, OprD family; Region: OprD; pfam03573
351746006191	similar to hypothetical protein
351746006192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006194	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746006195	putative effector binding pocket; other site
351746006196	dimerization interface [polypeptide binding]; other site
351746006197	hypothetical protein; Provisional; Region: PRK10621
351746006198	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746006199	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746006200	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746006201	metal binding site [ion binding]; metal-binding site
351746006202	active site
351746006203	I-site; other site
351746006204	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
351746006205	transmembrane helices; other site
351746006206	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
351746006207	TrkA-C domain; Region: TrkA_C; pfam02080
351746006208	TrkA-C domain; Region: TrkA_C; pfam02080
351746006209	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
351746006210	transmembrane helices; other site
351746006211	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
351746006212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746006213	S-adenosylmethionine binding site [chemical binding]; other site
351746006214	short chain dehydrogenase; Provisional; Region: PRK07035
351746006215	classical (c) SDRs; Region: SDR_c; cd05233
351746006216	NAD(P) binding site [chemical binding]; other site
351746006217	active site
351746006218	Phosphotransferase enzyme family; Region: APH; pfam01636
351746006219	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
351746006220	putative active site [active]
351746006221	putative substrate binding site [chemical binding]; other site
351746006222	ATP binding site [chemical binding]; other site
351746006223	SCP-2 sterol transfer family; Region: SCP2; pfam02036
351746006224	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
351746006225	catalytic core [active]
351746006226	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
351746006227	putative inner membrane peptidase; Provisional; Region: PRK11778
351746006228	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
351746006229	tandem repeat interface [polypeptide binding]; other site
351746006230	oligomer interface [polypeptide binding]; other site
351746006231	active site residues [active]
351746006232	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
351746006233	hypothetical protein; Provisional; Region: PRK04140
351746006234	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
351746006235	ERF superfamily; Region: ERF; pfam04404
351746006236	Isochorismatase family; Region: Isochorismatase; pfam00857
351746006237	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
351746006238	catalytic triad [active]
351746006239	conserved cis-peptide bond; other site
351746006240	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
351746006241	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
351746006242	putative NAD(P) binding site [chemical binding]; other site
351746006243	active site
351746006244	putative substrate binding site [chemical binding]; other site
351746006245	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
351746006246	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
351746006247	DNA binding residues [nucleotide binding]
351746006248	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
351746006249	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
351746006250	NAD binding site [chemical binding]; other site
351746006251	substrate binding site [chemical binding]; other site
351746006252	catalytic Zn binding site [ion binding]; other site
351746006253	tetramer interface [polypeptide binding]; other site
351746006254	structural Zn binding site [ion binding]; other site
351746006255	Predicted membrane protein [Function unknown]; Region: COG2259
351746006256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746006257	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
351746006258	putative active site [active]
351746006259	heme pocket [chemical binding]; other site
351746006260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746006261	dimer interface [polypeptide binding]; other site
351746006262	phosphorylation site [posttranslational modification]
351746006263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746006264	ATP binding site [chemical binding]; other site
351746006265	Mg2+ binding site [ion binding]; other site
351746006266	G-X-G motif; other site
351746006267	circadian clock protein KaiC; Reviewed; Region: PRK09302
351746006268	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746006269	Walker A motif; other site
351746006270	ATP binding site [chemical binding]; other site
351746006271	Walker B motif; other site
351746006272	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746006273	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746006274	Walker A motif; other site
351746006275	Walker A motif; other site
351746006276	ATP binding site [chemical binding]; other site
351746006277	Walker B motif; other site
351746006278	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006280	active site
351746006281	phosphorylation site [posttranslational modification]
351746006282	intermolecular recognition site; other site
351746006283	dimerization interface [polypeptide binding]; other site
351746006284	carbon storage regulator; Provisional; Region: PRK01712
351746006285	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
351746006286	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
351746006287	active site
351746006288	DNA binding site [nucleotide binding]
351746006289	Int/Topo IB signature motif; other site
351746006290	catalytic residues [active]
351746006291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746006292	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
351746006293	Walker A/P-loop; other site
351746006294	ATP binding site [chemical binding]; other site
351746006295	Q-loop/lid; other site
351746006296	ABC transporter signature motif; other site
351746006297	Walker B; other site
351746006298	D-loop; other site
351746006299	H-loop/switch region; other site
351746006300	TOBE domain; Region: TOBE; cl01440
351746006301	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
351746006302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746006303	dimer interface [polypeptide binding]; other site
351746006304	conserved gate region; other site
351746006305	putative PBP binding loops; other site
351746006306	ABC-ATPase subunit interface; other site
351746006307	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
351746006308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746006309	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
351746006310	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
351746006311	FMN binding site [chemical binding]; other site
351746006312	substrate binding site [chemical binding]; other site
351746006313	putative catalytic residue [active]
351746006314	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
351746006315	Cytochrome c553 [Energy production and conversion]; Region: COG2863
351746006316	Cytochrome c; Region: Cytochrom_C; cl11414
351746006317	Cytochrome c [Energy production and conversion]; Region: COG3258
351746006318	Cytochrome c; Region: Cytochrom_C; pfam00034
351746006319	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
351746006320	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
351746006321	active site
351746006322	tetramer interface; other site
351746006323	glutathione reductase; Validated; Region: PRK06116
351746006324	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746006325	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746006326	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351746006327	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
351746006328	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746006329	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746006330	ligand binding site [chemical binding]; other site
351746006331	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
351746006332	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746006333	Walker A/P-loop; other site
351746006334	ATP binding site [chemical binding]; other site
351746006335	Q-loop/lid; other site
351746006336	ABC transporter signature motif; other site
351746006337	Walker B; other site
351746006338	D-loop; other site
351746006339	H-loop/switch region; other site
351746006340	TOBE domain; Region: TOBE_2; pfam08402
351746006341	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746006342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746006343	dimer interface [polypeptide binding]; other site
351746006344	conserved gate region; other site
351746006345	putative PBP binding loops; other site
351746006346	ABC-ATPase subunit interface; other site
351746006347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746006348	dimer interface [polypeptide binding]; other site
351746006349	conserved gate region; other site
351746006350	putative PBP binding loops; other site
351746006351	ABC-ATPase subunit interface; other site
351746006352	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351746006353	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351746006354	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485
351746006355	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
351746006356	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
351746006357	dimerization interface [polypeptide binding]; other site
351746006358	active site
351746006359	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
351746006360	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
351746006361	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746006362	LysR family transcriptional regulator; Provisional; Region: PRK14997
351746006363	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006364	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746006365	putative effector binding pocket; other site
351746006366	dimerization interface [polypeptide binding]; other site
351746006367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
351746006368	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
351746006369	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
351746006370	catalytic triad [active]
351746006371	dimer interface [polypeptide binding]; other site
351746006372	conserved cis-peptide bond; other site
351746006373	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
351746006374	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
351746006375	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
351746006376	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
351746006377	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351746006378	ABC-ATPase subunit  interface; other site
351746006379	dimer interface [polypeptide binding]; other site
351746006380	putative PBP binding regions; other site
351746006381	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
351746006382	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
351746006383	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
351746006384	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
351746006385	metal binding site [ion binding]; metal-binding site
351746006386	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
351746006387	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
351746006388	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
351746006389	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
351746006390	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
351746006391	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746006392	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
351746006393	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
351746006394	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351746006395	active site
351746006396	DNA binding site [nucleotide binding]
351746006397	Int/Topo IB signature motif; other site
351746006398	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006399	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006400	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746006401	dimerization interface [polypeptide binding]; other site
351746006402	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
351746006403	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
351746006404	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
351746006405	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
351746006406	Thioredoxin; Region: Thioredoxin_4; pfam13462
351746006407	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
351746006408	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
351746006409	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746006410	Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977
351746006411	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746006412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746006413	homodimer interface [polypeptide binding]; other site
351746006414	catalytic residue [active]
351746006415	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351746006416	MarR family; Region: MarR_2; pfam12802
351746006417	Alginate lyase; Region: Alginate_lyase2; pfam08787
351746006418	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
351746006419	Predicted transcriptional regulator [Transcription]; Region: COG2932
351746006420	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746006421	Catalytic site [active]
351746006422	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
351746006423	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
351746006424	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
351746006425	shikimate binding site; other site
351746006426	NAD(P) binding site [chemical binding]; other site
351746006427	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
351746006428	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746006429	dimer interface [polypeptide binding]; other site
351746006430	active site
351746006431	metal binding site [ion binding]; metal-binding site
351746006432	glutathione binding site [chemical binding]; other site
351746006433	H-NS histone family; Region: Histone_HNS; pfam00816
351746006434	outer membrane porin, OprD family; Region: OprD; pfam03573
351746006435	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
351746006436	active site
351746006437	SAM binding site [chemical binding]; other site
351746006438	homodimer interface [polypeptide binding]; other site
351746006439	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006441	active site
351746006442	phosphorylation site [posttranslational modification]
351746006443	intermolecular recognition site; other site
351746006444	dimerization interface [polypeptide binding]; other site
351746006445	CHASE3 domain; Region: CHASE3; pfam05227
351746006446	GAF domain; Region: GAF; cl17456
351746006447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746006448	dimer interface [polypeptide binding]; other site
351746006449	phosphorylation site [posttranslational modification]
351746006450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746006451	ATP binding site [chemical binding]; other site
351746006452	Mg2+ binding site [ion binding]; other site
351746006453	G-X-G motif; other site
351746006454	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006456	active site
351746006457	phosphorylation site [posttranslational modification]
351746006458	intermolecular recognition site; other site
351746006459	dimerization interface [polypeptide binding]; other site
351746006460	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006462	active site
351746006463	phosphorylation site [posttranslational modification]
351746006464	intermolecular recognition site; other site
351746006465	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006467	active site
351746006468	phosphorylation site [posttranslational modification]
351746006469	intermolecular recognition site; other site
351746006470	dimerization interface [polypeptide binding]; other site
351746006471	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
351746006472	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
351746006473	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
351746006474	CheB methylesterase; Region: CheB_methylest; pfam01339
351746006475	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006477	active site
351746006478	phosphorylation site [posttranslational modification]
351746006479	intermolecular recognition site; other site
351746006480	dimerization interface [polypeptide binding]; other site
351746006481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746006482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746006483	dimer interface [polypeptide binding]; other site
351746006484	phosphorylation site [posttranslational modification]
351746006485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746006486	ATP binding site [chemical binding]; other site
351746006487	Mg2+ binding site [ion binding]; other site
351746006488	G-X-G motif; other site
351746006489	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006491	active site
351746006492	phosphorylation site [posttranslational modification]
351746006493	intermolecular recognition site; other site
351746006494	dimerization interface [polypeptide binding]; other site
351746006495	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746006496	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746006497	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
351746006498	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
351746006499	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746006500	beta-ketothiolase; Provisional; Region: PRK09051
351746006501	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746006502	dimer interface [polypeptide binding]; other site
351746006503	active site
351746006504	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746006505	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746006506	SurA N-terminal domain; Region: SurA_N; pfam09312
351746006507	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746006508	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
351746006509	Uncharacterized conserved protein [Function unknown]; Region: COG2128
351746006510	putative cyanate transporter; Provisional; Region: cynX; PRK09705
351746006511	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746006512	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006513	DNA-binding site [nucleotide binding]; DNA binding site
351746006514	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746006515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746006516	homodimer interface [polypeptide binding]; other site
351746006517	catalytic residue [active]
351746006518	Domain of unknown function (DUF336); Region: DUF336; cl01249
351746006519	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
351746006520	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351746006521	Cysteine-rich domain; Region: CCG; pfam02754
351746006522	Cysteine-rich domain; Region: CCG; pfam02754
351746006523	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
351746006524	FAD binding domain; Region: FAD_binding_4; pfam01565
351746006525	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
351746006526	FAD binding domain; Region: FAD_binding_4; pfam01565
351746006527	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
351746006528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006529	DNA-binding site [nucleotide binding]; DNA binding site
351746006530	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746006531	conserverd hypothetical protein; Region: TIGR02448
351746006532	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
351746006533	maleylacetoacetate isomerase; Region: maiA; TIGR01262
351746006534	putative C-terminal domain interface [polypeptide binding]; other site
351746006535	putative GSH binding site (G-site) [chemical binding]; other site
351746006536	putative dimer interface [polypeptide binding]; other site
351746006537	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
351746006538	N-terminal domain interface [polypeptide binding]; other site
351746006539	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
351746006540	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
351746006541	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351746006542	benzoate transport; Region: 2A0115; TIGR00895
351746006543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006544	outer membrane porin, OprD family; Region: OprD; pfam03573
351746006545	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746006546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006547	DNA-binding site [nucleotide binding]; DNA binding site
351746006548	FCD domain; Region: FCD; pfam07729
351746006549	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
351746006550	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
351746006551	FMN-binding pocket [chemical binding]; other site
351746006552	flavin binding motif; other site
351746006553	phosphate binding motif [ion binding]; other site
351746006554	beta-alpha-beta structure motif; other site
351746006555	NAD binding pocket [chemical binding]; other site
351746006556	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
351746006557	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746006558	catalytic loop [active]
351746006559	iron binding site [ion binding]; other site
351746006560	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
351746006561	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
351746006562	iron-sulfur cluster [ion binding]; other site
351746006563	[2Fe-2S] cluster binding site [ion binding]; other site
351746006564	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
351746006565	alpha subunit interface [polypeptide binding]; other site
351746006566	active site
351746006567	substrate binding site [chemical binding]; other site
351746006568	Fe binding site [ion binding]; other site
351746006569	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351746006570	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351746006571	Walker A/P-loop; other site
351746006572	ATP binding site [chemical binding]; other site
351746006573	Q-loop/lid; other site
351746006574	ABC transporter signature motif; other site
351746006575	Walker B; other site
351746006576	D-loop; other site
351746006577	H-loop/switch region; other site
351746006578	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351746006579	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
351746006580	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
351746006581	enoyl-CoA hydratase; Provisional; Region: PRK06688
351746006582	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746006583	substrate binding site [chemical binding]; other site
351746006584	oxyanion hole (OAH) forming residues; other site
351746006585	trimer interface [polypeptide binding]; other site
351746006586	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
351746006587	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746006588	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
351746006589	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
351746006590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006591	active site
351746006592	phosphorylation site [posttranslational modification]
351746006593	intermolecular recognition site; other site
351746006594	dimerization interface [polypeptide binding]; other site
351746006595	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746006596	DNA binding site [nucleotide binding]
351746006597	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746006598	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746006599	substrate binding pocket [chemical binding]; other site
351746006600	membrane-bound complex binding site; other site
351746006601	hinge residues; other site
351746006602	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746006603	dimer interface [polypeptide binding]; other site
351746006604	phosphorylation site [posttranslational modification]
351746006605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746006606	ATP binding site [chemical binding]; other site
351746006607	Mg2+ binding site [ion binding]; other site
351746006608	G-X-G motif; other site
351746006609	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006611	active site
351746006612	phosphorylation site [posttranslational modification]
351746006613	intermolecular recognition site; other site
351746006614	dimerization interface [polypeptide binding]; other site
351746006615	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
351746006616	putative binding surface; other site
351746006617	active site
351746006618	S-methylmethionine transporter; Provisional; Region: PRK11387
351746006619	enoyl-CoA hydratase; Provisional; Region: PRK06688
351746006620	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746006621	substrate binding site [chemical binding]; other site
351746006622	oxyanion hole (OAH) forming residues; other site
351746006623	trimer interface [polypeptide binding]; other site
351746006624	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746006625	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746006626	active site
351746006627	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
351746006628	CoA binding domain; Region: CoA_binding_2; pfam13380
351746006629	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
351746006630	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
351746006631	hypothetical protein; Provisional; Region: PRK07524
351746006632	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746006633	PYR/PP interface [polypeptide binding]; other site
351746006634	dimer interface [polypeptide binding]; other site
351746006635	TPP binding site [chemical binding]; other site
351746006636	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746006637	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
351746006638	TPP-binding site [chemical binding]; other site
351746006639	alanine racemase; Reviewed; Region: PRK13340
351746006640	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826
351746006641	active site
351746006642	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746006643	dimer interface [polypeptide binding]; other site
351746006644	substrate binding site [chemical binding]; other site
351746006645	catalytic residues [active]
351746006646	aspartate aminotransferase; Provisional; Region: PRK05764
351746006647	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746006648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746006649	homodimer interface [polypeptide binding]; other site
351746006650	catalytic residue [active]
351746006651	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
351746006652	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746006653	NAD binding site [chemical binding]; other site
351746006654	catalytic residues [active]
351746006655	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
351746006656	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746006657	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746006658	hypothetical protein; Provisional; Region: PRK07036
351746006659	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746006660	inhibitor-cofactor binding pocket; inhibition site
351746006661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746006662	catalytic residue [active]
351746006663	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746006664	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746006665	DNA binding residues [nucleotide binding]
351746006666	dimerization interface [polypeptide binding]; other site
351746006667	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
351746006668	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746006669	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746006670	DNA binding residues [nucleotide binding]
351746006671	dimerization interface [polypeptide binding]; other site
351746006672	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
351746006673	FAD binding domain; Region: FAD_binding_4; pfam01565
351746006674	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
351746006675	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
351746006676	classical (c) SDRs; Region: SDR_c; cd05233
351746006677	NAD(P) binding site [chemical binding]; other site
351746006678	active site
351746006679	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
351746006680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006681	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746006682	dimerization interface [polypeptide binding]; other site
351746006683	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
351746006684	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
351746006685	octamer interface [polypeptide binding]; other site
351746006686	active site
351746006687	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
351746006688	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
351746006689	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
351746006690	dimer interface [polypeptide binding]; other site
351746006691	active site
351746006692	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746006693	Coenzyme A binding pocket [chemical binding]; other site
351746006694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746006695	PAS domain; Region: PAS_9; pfam13426
351746006696	putative active site [active]
351746006697	heme pocket [chemical binding]; other site
351746006698	PAS fold; Region: PAS_4; pfam08448
351746006699	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746006700	putative active site [active]
351746006701	heme pocket [chemical binding]; other site
351746006702	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746006703	metal binding site [ion binding]; metal-binding site
351746006704	active site
351746006705	I-site; other site
351746006706	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746006707	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746006708	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746006709	active site
351746006710	catalytic tetrad [active]
351746006711	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351746006712	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006713	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006714	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
351746006715	putative substrate binding pocket [chemical binding]; other site
351746006716	putative dimerization interface [polypeptide binding]; other site
351746006717	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
351746006718	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
351746006719	dimer interface [polypeptide binding]; other site
351746006720	active site
351746006721	heme binding site [chemical binding]; other site
351746006722	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
351746006723	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
351746006724	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
351746006725	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
351746006726	active site
351746006727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006728	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746006729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006730	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746006731	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
351746006732	conserved cys residue [active]
351746006733	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746006734	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
351746006735	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
351746006736	domain interface [polypeptide binding]; other site
351746006737	putative active site [active]
351746006738	catalytic site [active]
351746006739	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
351746006740	domain interface [polypeptide binding]; other site
351746006741	putative active site [active]
351746006742	catalytic site [active]
351746006743	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746006744	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746006745	metal binding site [ion binding]; metal-binding site
351746006746	active site
351746006747	I-site; other site
351746006748	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
351746006749	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
351746006750	Predicted membrane protein [Function unknown]; Region: COG2855
351746006751	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006752	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006753	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
351746006754	putative dimerization interface [polypeptide binding]; other site
351746006755	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
351746006756	putative active site [active]
351746006757	putative catalytic site [active]
351746006758	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746006759	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746006760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746006761	benzoate transport; Region: 2A0115; TIGR00895
351746006762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006763	putative substrate translocation pore; other site
351746006764	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
351746006765	putative FMN binding site [chemical binding]; other site
351746006766	outer membrane porin, OprD family; Region: OprD; pfam03573
351746006767	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
351746006768	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
351746006769	Na binding site [ion binding]; other site
351746006770	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746006771	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746006772	putative DNA binding site [nucleotide binding]; other site
351746006773	putative Zn2+ binding site [ion binding]; other site
351746006774	AsnC family; Region: AsnC_trans_reg; pfam01037
351746006775	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746006776	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746006777	PAS fold; Region: PAS_4; pfam08448
351746006778	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
351746006779	GAF domain; Region: GAF; pfam01590
351746006780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746006781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746006782	dimer interface [polypeptide binding]; other site
351746006783	phosphorylation site [posttranslational modification]
351746006784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746006785	ATP binding site [chemical binding]; other site
351746006786	Mg2+ binding site [ion binding]; other site
351746006787	G-X-G motif; other site
351746006788	Response regulator receiver domain; Region: Response_reg; pfam00072
351746006789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746006790	active site
351746006791	phosphorylation site [posttranslational modification]
351746006792	intermolecular recognition site; other site
351746006793	dimerization interface [polypeptide binding]; other site
351746006794	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
351746006795	nudix motif; other site
351746006796	Transcriptional regulators [Transcription]; Region: GntR; COG1802
351746006797	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006798	DNA-binding site [nucleotide binding]; DNA binding site
351746006799	FCD domain; Region: FCD; pfam07729
351746006800	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
351746006801	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
351746006802	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746006803	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
351746006804	NAD(P) binding site [chemical binding]; other site
351746006805	catalytic residues [active]
351746006806	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
351746006807	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
351746006808	Amino acid synthesis; Region: AA_synth; pfam06684
351746006809	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
351746006810	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
351746006811	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
351746006812	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
351746006813	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
351746006814	Na binding site [ion binding]; other site
351746006815	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
351746006816	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746006817	dimerization interface [polypeptide binding]; other site
351746006818	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746006819	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746006820	dimer interface [polypeptide binding]; other site
351746006821	putative CheW interface [polypeptide binding]; other site
351746006822	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
351746006823	Cupin; Region: Cupin_6; pfam12852
351746006824	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746006825	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746006826	Uncharacterized conserved protein [Function unknown]; Region: COG2128
351746006827	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
351746006828	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746006829	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746006830	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
351746006831	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
351746006832	Walker A/P-loop; other site
351746006833	ATP binding site [chemical binding]; other site
351746006834	Q-loop/lid; other site
351746006835	ABC transporter signature motif; other site
351746006836	Walker B; other site
351746006837	D-loop; other site
351746006838	H-loop/switch region; other site
351746006839	NMT1-like family; Region: NMT1_2; pfam13379
351746006840	NMT1/THI5 like; Region: NMT1; pfam09084
351746006841	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
351746006842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746006843	dimer interface [polypeptide binding]; other site
351746006844	conserved gate region; other site
351746006845	putative PBP binding loops; other site
351746006846	ABC-ATPase subunit interface; other site
351746006847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746006848	Coenzyme A binding pocket [chemical binding]; other site
351746006849	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
351746006850	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351746006851	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746006852	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746006853	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746006854	dimerization interface [polypeptide binding]; other site
351746006855	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
351746006856	Bacterial SH3 domain; Region: SH3_3; pfam08239
351746006857	outer membrane porin, OprD family; Region: OprD; pfam03573
351746006858	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
351746006859	dimer interface [polypeptide binding]; other site
351746006860	BCCT family transporter; Region: BCCT; pfam02028
351746006861	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
351746006862	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746006863	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746006864	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746006865	substrate binding pocket [chemical binding]; other site
351746006866	membrane-bound complex binding site; other site
351746006867	hinge residues; other site
351746006868	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746006869	Cytochrome c; Region: Cytochrom_C; pfam00034
351746006870	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746006871	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
351746006872	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
351746006873	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746006874	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746006875	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
351746006876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746006877	catalytic loop [active]
351746006878	iron binding site [ion binding]; other site
351746006879	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
351746006880	YcaO domain protein; Region: TIGR03549
351746006881	OsmC-like protein; Region: OsmC; pfam02566
351746006882	YcaO-like family; Region: YcaO; pfam02624
351746006883	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
351746006884	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
351746006885	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
351746006886	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
351746006887	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
351746006888	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
351746006889	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
351746006890	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
351746006891	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
351746006892	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
351746006893	FHA domain; Region: FHA; pfam00498
351746006894	phosphopeptide binding site; other site
351746006895	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
351746006896	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
351746006897	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
351746006898	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
351746006899	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
351746006900	Protein of unknown function (DUF877); Region: DUF877; pfam05943
351746006901	Protein of unknown function (DUF770); Region: DUF770; pfam05591
351746006902	Protein of unknown function (DUF3121); Region: DUF3121; pfam11319
351746006903	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
351746006904	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
351746006905	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
351746006906	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
351746006907	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
351746006908	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351746006909	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746006910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746006911	Walker A/P-loop; other site
351746006912	ATP binding site [chemical binding]; other site
351746006913	Q-loop/lid; other site
351746006914	ABC transporter signature motif; other site
351746006915	Walker B; other site
351746006916	D-loop; other site
351746006917	H-loop/switch region; other site
351746006918	Protein of unknown function (DUF2819); Region: DUF2819; cl17862
351746006919	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
351746006920	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
351746006921	YhjQ protein; Region: YhjQ; pfam06564
351746006922	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
351746006923	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
351746006924	DXD motif; other site
351746006925	PilZ domain; Region: PilZ; pfam07238
351746006926	cellulose synthase regulator protein; Provisional; Region: PRK11114
351746006927	endo-1,4-D-glucanase; Provisional; Region: PRK11097
351746006928	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
351746006929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746006930	binding surface
351746006931	TPR motif; other site
351746006932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746006933	binding surface
351746006934	TPR motif; other site
351746006935	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
351746006936	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
351746006937	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
351746006938	dimer interface [polypeptide binding]; other site
351746006939	active site
351746006940	catalytic residue [active]
351746006941	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
351746006942	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
351746006943	multimer interface [polypeptide binding]; other site
351746006944	active site
351746006945	catalytic triad [active]
351746006946	dimer interface [polypeptide binding]; other site
351746006947	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
351746006948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746006949	Walker A motif; other site
351746006950	ATP binding site [chemical binding]; other site
351746006951	Walker B motif; other site
351746006952	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
351746006953	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746006954	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
351746006955	ligand binding site [chemical binding]; other site
351746006956	regulator interaction site; other site
351746006957	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
351746006958	ANTAR domain; Region: ANTAR; pfam03861
351746006959	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
351746006960	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
351746006961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746006962	Coenzyme A binding pocket [chemical binding]; other site
351746006963	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
351746006964	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746006965	catalytic loop [active]
351746006966	iron binding site [ion binding]; other site
351746006967	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
351746006968	FAD binding pocket [chemical binding]; other site
351746006969	FAD binding motif [chemical binding]; other site
351746006970	phosphate binding motif [ion binding]; other site
351746006971	beta-alpha-beta structure motif; other site
351746006972	NAD binding pocket [chemical binding]; other site
351746006973	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
351746006974	active site
351746006975	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746006976	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746006977	DNA-binding site [nucleotide binding]; DNA binding site
351746006978	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746006979	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746006980	homodimer interface [polypeptide binding]; other site
351746006981	catalytic residue [active]
351746006982	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
351746006983	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746006984	dimerization interface [polypeptide binding]; other site
351746006985	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746006986	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746006987	dimer interface [polypeptide binding]; other site
351746006988	putative CheW interface [polypeptide binding]; other site
351746006989	magnesium-transporting ATPase; Provisional; Region: PRK15122
351746006990	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
351746006991	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746006992	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
351746006993	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
351746006994	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351746006995	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
351746006996	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
351746006997	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
351746006998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746006999	putative substrate translocation pore; other site
351746007000	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351746007001	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
351746007002	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746007003	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007004	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746007005	Ligand Binding Site [chemical binding]; other site
351746007006	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746007007	Ligand Binding Site [chemical binding]; other site
351746007008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007010	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746007011	dimerization interface [polypeptide binding]; other site
351746007012	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351746007013	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
351746007014	putative active site [active]
351746007015	metal binding site [ion binding]; metal-binding site
351746007016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007017	D-galactonate transporter; Region: 2A0114; TIGR00893
351746007018	putative substrate translocation pore; other site
351746007019	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
351746007020	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746007021	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746007022	non-specific DNA binding site [nucleotide binding]; other site
351746007023	salt bridge; other site
351746007024	sequence-specific DNA binding site [nucleotide binding]; other site
351746007025	MAPEG family; Region: MAPEG; pfam01124
351746007026	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
351746007027	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
351746007028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746007029	dimer interface [polypeptide binding]; other site
351746007030	conserved gate region; other site
351746007031	putative PBP binding loops; other site
351746007032	ABC-ATPase subunit interface; other site
351746007033	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
351746007034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746007035	dimer interface [polypeptide binding]; other site
351746007036	conserved gate region; other site
351746007037	putative PBP binding loops; other site
351746007038	ABC-ATPase subunit interface; other site
351746007039	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
351746007040	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
351746007041	Walker A/P-loop; other site
351746007042	ATP binding site [chemical binding]; other site
351746007043	Q-loop/lid; other site
351746007044	ABC transporter signature motif; other site
351746007045	Walker B; other site
351746007046	D-loop; other site
351746007047	H-loop/switch region; other site
351746007048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
351746007049	active site
351746007050	motif I; other site
351746007051	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
351746007052	motif II; other site
351746007053	Gram-negative porin; Region: Porin_4; pfam13609
351746007054	Uncharacterized conserved protein [Function unknown]; Region: COG3287
351746007055	FIST N domain; Region: FIST; pfam08495
351746007056	FIST C domain; Region: FIST_C; pfam10442
351746007057	PAS fold; Region: PAS; pfam00989
351746007058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
351746007059	putative active site [active]
351746007060	heme pocket [chemical binding]; other site
351746007061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746007062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007063	dimer interface [polypeptide binding]; other site
351746007064	phosphorylation site [posttranslational modification]
351746007065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007066	ATP binding site [chemical binding]; other site
351746007067	Mg2+ binding site [ion binding]; other site
351746007068	G-X-G motif; other site
351746007069	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746007070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007071	active site
351746007072	phosphorylation site [posttranslational modification]
351746007073	intermolecular recognition site; other site
351746007074	dimerization interface [polypeptide binding]; other site
351746007075	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746007076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007077	active site
351746007078	phosphorylation site [posttranslational modification]
351746007079	intermolecular recognition site; other site
351746007080	dimerization interface [polypeptide binding]; other site
351746007081	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746007082	DNA binding residues [nucleotide binding]
351746007083	dimerization interface [polypeptide binding]; other site
351746007084	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
351746007085	active site residue [active]
351746007086	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
351746007087	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746007088	Walker A/P-loop; other site
351746007089	ATP binding site [chemical binding]; other site
351746007090	Q-loop/lid; other site
351746007091	ABC transporter signature motif; other site
351746007092	Walker B; other site
351746007093	D-loop; other site
351746007094	H-loop/switch region; other site
351746007095	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746007096	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351746007097	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746007098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
351746007099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746007100	dimer interface [polypeptide binding]; other site
351746007101	putative PBP binding loops; other site
351746007102	ABC-ATPase subunit interface; other site
351746007103	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746007104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746007105	dimer interface [polypeptide binding]; other site
351746007106	conserved gate region; other site
351746007107	putative PBP binding loops; other site
351746007108	ABC-ATPase subunit interface; other site
351746007109	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746007110	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746007111	substrate binding pocket [chemical binding]; other site
351746007112	membrane-bound complex binding site; other site
351746007113	hinge residues; other site
351746007114	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
351746007115	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
351746007116	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
351746007117	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
351746007118	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
351746007119	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746007120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746007121	homodimer interface [polypeptide binding]; other site
351746007122	catalytic residue [active]
351746007123	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
351746007124	serine transporter; Region: stp; TIGR00814
351746007125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007126	putative substrate translocation pore; other site
351746007127	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746007128	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
351746007129	dimer interface [polypeptide binding]; other site
351746007130	catalytic triad [active]
351746007131	peroxidatic and resolving cysteines [active]
351746007132	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746007133	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746007134	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746007135	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
351746007136	Protein export membrane protein; Region: SecD_SecF; cl14618
351746007137	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
351746007138	Protein export membrane protein; Region: SecD_SecF; cl14618
351746007139	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
351746007140	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
351746007141	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
351746007142	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
351746007143	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746007144	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746007145	metal binding site [ion binding]; metal-binding site
351746007146	active site
351746007147	I-site; other site
351746007148	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746007149	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
351746007150	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
351746007151	phosphoglucomutase; Validated; Region: PRK07564
351746007152	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
351746007153	active site
351746007154	substrate binding site [chemical binding]; other site
351746007155	metal binding site [ion binding]; metal-binding site
351746007156	RNA polymerase sigma factor; Provisional; Region: PRK12528
351746007157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746007158	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
351746007159	DNA binding residues [nucleotide binding]
351746007160	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746007161	FecR protein; Region: FecR; pfam04773
351746007162	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746007163	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746007164	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746007165	N-terminal plug; other site
351746007166	ligand-binding site [chemical binding]; other site
351746007167	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
351746007168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746007170	dimerization interface [polypeptide binding]; other site
351746007171	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
351746007172	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
351746007173	active site
351746007174	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
351746007175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746007176	NAD(P) binding site [chemical binding]; other site
351746007177	active site
351746007178	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746007179	homotrimer interaction site [polypeptide binding]; other site
351746007180	putative active site [active]
351746007181	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
351746007182	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746007183	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
351746007184	acetylornithine deacetylase; Provisional; Region: PRK07522
351746007185	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
351746007186	metal binding site [ion binding]; metal-binding site
351746007187	putative dimer interface [polypeptide binding]; other site
351746007188	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
351746007189	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
351746007190	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
351746007191	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
351746007192	Trp docking motif [polypeptide binding]; other site
351746007193	putative active site [active]
351746007194	Cupin domain; Region: Cupin_2; cl17218
351746007195	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007196	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007197	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746007198	putative effector binding pocket; other site
351746007199	dimerization interface [polypeptide binding]; other site
351746007200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007201	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
351746007202	LysE type translocator; Region: LysE; cl00565
351746007203	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746007204	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
351746007205	conserved cys residue [active]
351746007206	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007207	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
351746007208	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
351746007209	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
351746007210	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
351746007211	Predicted permeases [General function prediction only]; Region: COG0679
351746007212	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007213	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007214	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
351746007215	putative dimerization interface [polypeptide binding]; other site
351746007216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746007217	dimer interface [polypeptide binding]; other site
351746007218	conserved gate region; other site
351746007219	ABC-ATPase subunit interface; other site
351746007220	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
351746007221	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
351746007222	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746007223	dimerization interface [polypeptide binding]; other site
351746007224	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746007225	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746007226	dimer interface [polypeptide binding]; other site
351746007227	putative CheW interface [polypeptide binding]; other site
351746007228	Predicted permease [General function prediction only]; Region: COG2056
351746007229	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
351746007230	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
351746007231	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746007232	FecR protein; Region: FecR; pfam04773
351746007233	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
351746007234	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746007235	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746007236	active site
351746007237	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746007238	acyl-CoA synthetase; Validated; Region: PRK08162
351746007239	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
351746007240	acyl-activating enzyme (AAE) consensus motif; other site
351746007241	putative active site [active]
351746007242	AMP binding site [chemical binding]; other site
351746007243	putative CoA binding site [chemical binding]; other site
351746007244	PAS domain S-box; Region: sensory_box; TIGR00229
351746007245	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746007246	putative active site [active]
351746007247	heme pocket [chemical binding]; other site
351746007248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007249	dimer interface [polypeptide binding]; other site
351746007250	phosphorylation site [posttranslational modification]
351746007251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007252	ATP binding site [chemical binding]; other site
351746007253	G-X-G motif; other site
351746007254	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
351746007255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007256	active site
351746007257	phosphorylation site [posttranslational modification]
351746007258	intermolecular recognition site; other site
351746007259	dimerization interface [polypeptide binding]; other site
351746007260	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746007261	DNA binding residues [nucleotide binding]
351746007262	dimerization interface [polypeptide binding]; other site
351746007263	MarR family; Region: MarR_2; cl17246
351746007264	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351746007265	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
351746007266	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746007267	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746007268	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
351746007269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007270	putative substrate translocation pore; other site
351746007271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007272	short chain dehydrogenase; Provisional; Region: PRK06123
351746007273	classical (c) SDRs; Region: SDR_c; cd05233
351746007274	NAD(P) binding site [chemical binding]; other site
351746007275	active site
351746007276	PAS fold; Region: PAS_7; pfam12860
351746007277	PAS fold; Region: PAS_4; pfam08448
351746007278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007279	ATP binding site [chemical binding]; other site
351746007280	Mg2+ binding site [ion binding]; other site
351746007281	G-X-G motif; other site
351746007282	Response regulator receiver domain; Region: Response_reg; pfam00072
351746007283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007284	active site
351746007285	phosphorylation site [posttranslational modification]
351746007286	intermolecular recognition site; other site
351746007287	dimerization interface [polypeptide binding]; other site
351746007288	PAS fold; Region: PAS_4; pfam08448
351746007289	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007290	dimer interface [polypeptide binding]; other site
351746007291	phosphorylation site [posttranslational modification]
351746007292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007293	ATP binding site [chemical binding]; other site
351746007294	Mg2+ binding site [ion binding]; other site
351746007295	G-X-G motif; other site
351746007296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007297	active site
351746007298	phosphorylation site [posttranslational modification]
351746007299	intermolecular recognition site; other site
351746007300	dimerization interface [polypeptide binding]; other site
351746007301	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746007302	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746007303	DNA-binding site [nucleotide binding]; DNA binding site
351746007304	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746007305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746007306	homodimer interface [polypeptide binding]; other site
351746007307	catalytic residue [active]
351746007308	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
351746007309	4Fe-4S binding domain; Region: Fer4_5; pfam12801
351746007310	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
351746007311	Protein of unknown function (DUF3203); Region: DUF3203; pfam11462
351746007312	MgtC family; Region: MgtC; pfam02308
351746007313	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
351746007314	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
351746007315	active site
351746007316	catalytic residues [active]
351746007317	metal binding site [ion binding]; metal-binding site
351746007318	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
351746007319	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
351746007320	DNA binding residues [nucleotide binding]
351746007321	putative dimer interface [polypeptide binding]; other site
351746007322	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746007323	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746007324	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007325	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
351746007326	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
351746007327	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
351746007328	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
351746007329	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007330	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007331	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746007332	dimerization interface [polypeptide binding]; other site
351746007333	ornithine cyclodeaminase; Validated; Region: PRK07589
351746007334	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
351746007335	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746007336	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
351746007337	putative DNA binding site [nucleotide binding]; other site
351746007338	putative Zn2+ binding site [ion binding]; other site
351746007339	AsnC family; Region: AsnC_trans_reg; pfam01037
351746007340	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
351746007341	hydrophobic ligand binding site; other site
351746007342	hypothetical protein; Provisional; Region: PRK11171
351746007343	Cupin domain; Region: Cupin_2; pfam07883
351746007344	Cupin domain; Region: Cupin_2; pfam07883
351746007345	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
351746007346	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
351746007347	active site
351746007348	non-prolyl cis peptide bond; other site
351746007349	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
351746007350	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746007351	substrate binding pocket [chemical binding]; other site
351746007352	membrane-bound complex binding site; other site
351746007353	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746007354	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746007355	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746007356	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
351746007357	conserved cys residue [active]
351746007358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007359	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
351746007360	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746007361	homotrimer interaction site [polypeptide binding]; other site
351746007362	putative active site [active]
351746007363	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746007364	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
351746007365	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
351746007366	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
351746007367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746007368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007369	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
351746007370	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
351746007371	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
351746007372	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
351746007373	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
351746007374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007376	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746007377	dimerization interface [polypeptide binding]; other site
351746007378	Predicted membrane protein [Function unknown]; Region: COG4125
351746007379	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
351746007380	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
351746007381	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
351746007382	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
351746007383	homodimer interface [polypeptide binding]; other site
351746007384	substrate-cofactor binding pocket; other site
351746007385	catalytic residue [active]
351746007386	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
351746007387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746007388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746007389	Walker A/P-loop; other site
351746007390	Walker A/P-loop; other site
351746007391	ATP binding site [chemical binding]; other site
351746007392	ATP binding site [chemical binding]; other site
351746007393	Q-loop/lid; other site
351746007394	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746007395	ABC transporter signature motif; other site
351746007396	Walker B; other site
351746007397	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746007398	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746007399	Walker A motif; other site
351746007400	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
351746007401	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
351746007402	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
351746007403	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
351746007404	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
351746007405	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
351746007406	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
351746007407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746007408	Walker A motif; other site
351746007409	ATP binding site [chemical binding]; other site
351746007410	Walker B motif; other site
351746007411	arginine finger; other site
351746007412	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
351746007413	metal ion-dependent adhesion site (MIDAS); other site
351746007414	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746007415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746007416	Walker A motif; other site
351746007417	ATP binding site [chemical binding]; other site
351746007418	Walker B motif; other site
351746007419	arginine finger; other site
351746007420	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746007421	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
351746007422	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
351746007423	Peptidase family U32; Region: Peptidase_U32; pfam01136
351746007424	Collagenase; Region: DUF3656; pfam12392
351746007425	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746007426	homotrimer interaction site [polypeptide binding]; other site
351746007427	putative active site [active]
351746007428	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
351746007429	Family of unknown function (DUF633); Region: DUF633; pfam04816
351746007430	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746007431	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007433	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746007434	putative effector binding pocket; other site
351746007435	dimerization interface [polypeptide binding]; other site
351746007436	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746007437	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746007438	active site
351746007439	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
351746007440	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746007441	substrate binding site [chemical binding]; other site
351746007442	oxyanion hole (OAH) forming residues; other site
351746007443	trimer interface [polypeptide binding]; other site
351746007444	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
351746007445	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
351746007446	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746007447	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746007448	FixH; Region: FixH; pfam05751
351746007449	YtkA-like; Region: YtkA; pfam13115
351746007450	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
351746007451	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
351746007452	Cu(I) binding site [ion binding]; other site
351746007453	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
351746007454	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
351746007455	Cu(I) binding site [ion binding]; other site
351746007456	Cytochrome c; Region: Cytochrom_C; pfam00034
351746007457	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746007458	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
351746007459	SurA N-terminal domain; Region: SurA_N_3; cl07813
351746007460	Response regulator receiver domain; Region: Response_reg; pfam00072
351746007461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007462	active site
351746007463	phosphorylation site [posttranslational modification]
351746007464	intermolecular recognition site; other site
351746007465	dimerization interface [polypeptide binding]; other site
351746007466	Type II/IV secretion system protein; Region: T2SE; pfam00437
351746007467	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
351746007468	Walker A motif; other site
351746007469	ATP binding site [chemical binding]; other site
351746007470	Walker B motif; other site
351746007471	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
351746007472	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746007473	TPR motif; other site
351746007474	binding surface
351746007475	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
351746007476	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746007477	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
351746007478	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
351746007479	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
351746007480	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
351746007481	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
351746007482	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
351746007483	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
351746007484	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
351746007485	curli assembly protein CsgE; Provisional; Region: PRK10386
351746007486	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
351746007487	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
351746007488	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
351746007489	GAF domain; Region: GAF; pfam01590
351746007490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746007491	putative active site [active]
351746007492	heme pocket [chemical binding]; other site
351746007493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746007494	ATP binding site [chemical binding]; other site
351746007495	Walker A motif; other site
351746007496	Walker B motif; other site
351746007497	arginine finger; other site
351746007498	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746007499	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
351746007500	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746007501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746007502	Walker A/P-loop; other site
351746007503	ATP binding site [chemical binding]; other site
351746007504	Q-loop/lid; other site
351746007505	ABC transporter signature motif; other site
351746007506	Walker B; other site
351746007507	D-loop; other site
351746007508	H-loop/switch region; other site
351746007509	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
351746007510	active site
351746007511	catalytic residues [active]
351746007512	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
351746007513	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
351746007514	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
351746007515	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746007516	NAD(P) binding site [chemical binding]; other site
351746007517	catalytic residues [active]
351746007518	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
351746007519	Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098
351746007520	Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099
351746007521	Domain of unknown function (DUF1928); Region: DUF1928; pfam09100
351746007522	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
351746007523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746007524	FeS/SAM binding site; other site
351746007525	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
351746007526	Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992
351746007527	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
351746007528	MutS domain II; Region: MutS_II; pfam05188
351746007529	acyl-CoA synthetase; Provisional; Region: PRK12583
351746007530	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746007531	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
351746007532	acyl-activating enzyme (AAE) consensus motif; other site
351746007533	putative AMP binding site [chemical binding]; other site
351746007534	putative active site [active]
351746007535	putative CoA binding site [chemical binding]; other site
351746007536	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
351746007537	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
351746007538	GTP binding site; other site
351746007539	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
351746007540	Protein export membrane protein; Region: SecD_SecF; cl14618
351746007541	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
351746007542	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351746007543	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746007544	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746007545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007546	active site
351746007547	phosphorylation site [posttranslational modification]
351746007548	intermolecular recognition site; other site
351746007549	dimerization interface [polypeptide binding]; other site
351746007550	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746007551	DNA binding site [nucleotide binding]
351746007552	sensor protein RstB; Provisional; Region: PRK10604
351746007553	HAMP domain; Region: HAMP; pfam00672
351746007554	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
351746007555	dimer interface [polypeptide binding]; other site
351746007556	phosphorylation site [posttranslational modification]
351746007557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007558	ATP binding site [chemical binding]; other site
351746007559	Mg2+ binding site [ion binding]; other site
351746007560	G-X-G motif; other site
351746007561	Predicted membrane protein [Function unknown]; Region: COG4125
351746007562	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
351746007563	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
351746007564	threonine dehydratase; Reviewed; Region: PRK12483
351746007565	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
351746007566	tetramer interface [polypeptide binding]; other site
351746007567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746007568	catalytic residue [active]
351746007569	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
351746007570	putative Ile/Val binding site [chemical binding]; other site
351746007571	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
351746007572	putative Ile/Val binding site [chemical binding]; other site
351746007573	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
351746007574	putative dimer interface [polypeptide binding]; other site
351746007575	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746007576	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
351746007577	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746007578	tetrameric interface [polypeptide binding]; other site
351746007579	activator binding site; other site
351746007580	NADP binding site [chemical binding]; other site
351746007581	substrate binding site [chemical binding]; other site
351746007582	catalytic residues [active]
351746007583	Protein of unknown function (DUF563); Region: DUF563; pfam04577
351746007584	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746007585	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746007586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746007588	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746007589	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
351746007590	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
351746007591	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
351746007592	Transporter associated domain; Region: CorC_HlyC; smart01091
351746007593	Predicted permeases [General function prediction only]; Region: RarD; COG2962
351746007594	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
351746007595	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
351746007596	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746007597	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
351746007598	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
351746007599	dimer interface [polypeptide binding]; other site
351746007600	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
351746007601	active site
351746007602	Fe binding site [ion binding]; other site
351746007603	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
351746007604	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
351746007605	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
351746007606	potential catalytic triad [active]
351746007607	conserved cys residue [active]
351746007608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746007609	PAS domain; Region: PAS_9; pfam13426
351746007610	putative active site [active]
351746007611	heme pocket [chemical binding]; other site
351746007612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007613	ATP binding site [chemical binding]; other site
351746007614	Mg2+ binding site [ion binding]; other site
351746007615	G-X-G motif; other site
351746007616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007617	active site
351746007618	phosphorylation site [posttranslational modification]
351746007619	intermolecular recognition site; other site
351746007620	dimerization interface [polypeptide binding]; other site
351746007621	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
351746007622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007623	dimer interface [polypeptide binding]; other site
351746007624	phosphorylation site [posttranslational modification]
351746007625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007626	ATP binding site [chemical binding]; other site
351746007627	Mg2+ binding site [ion binding]; other site
351746007628	G-X-G motif; other site
351746007629	Response regulator receiver domain; Region: Response_reg; pfam00072
351746007630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007631	active site
351746007632	phosphorylation site [posttranslational modification]
351746007633	intermolecular recognition site; other site
351746007634	dimerization interface [polypeptide binding]; other site
351746007635	TPR repeat; Region: TPR_11; pfam13414
351746007636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746007637	binding surface
351746007638	TPR motif; other site
351746007639	TPR repeat; Region: TPR_11; pfam13414
351746007640	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
351746007641	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
351746007642	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746007643	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746007644	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746007645	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
351746007646	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351746007647	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351746007648	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
351746007649	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
351746007650	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
351746007651	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746007652	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746007653	catalytic residue [active]
351746007654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746007655	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007656	dimer interface [polypeptide binding]; other site
351746007657	phosphorylation site [posttranslational modification]
351746007658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007659	ATP binding site [chemical binding]; other site
351746007660	Mg2+ binding site [ion binding]; other site
351746007661	G-X-G motif; other site
351746007662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746007663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007664	dimer interface [polypeptide binding]; other site
351746007665	phosphorylation site [posttranslational modification]
351746007666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007667	ATP binding site [chemical binding]; other site
351746007668	Mg2+ binding site [ion binding]; other site
351746007669	G-X-G motif; other site
351746007670	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746007671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007672	active site
351746007673	phosphorylation site [posttranslational modification]
351746007674	intermolecular recognition site; other site
351746007675	dimerization interface [polypeptide binding]; other site
351746007676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746007677	Walker A motif; other site
351746007678	ATP binding site [chemical binding]; other site
351746007679	Walker B motif; other site
351746007680	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746007681	fructuronate transporter; Provisional; Region: PRK10034; cl15264
351746007682	GntP family permease; Region: GntP_permease; pfam02447
351746007683	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
351746007684	AAA domain; Region: AAA_33; pfam13671
351746007685	ATP-binding site [chemical binding]; other site
351746007686	Gluconate-6-phosphate binding site [chemical binding]; other site
351746007687	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351746007688	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351746007689	DNA binding site [nucleotide binding]
351746007690	domain linker motif; other site
351746007691	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
351746007692	putative ligand binding site [chemical binding]; other site
351746007693	putative dimerization interface [polypeptide binding]; other site
351746007694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746007695	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
351746007696	putative active site [active]
351746007697	heme pocket [chemical binding]; other site
351746007698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746007699	putative active site [active]
351746007700	heme pocket [chemical binding]; other site
351746007701	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746007702	dimer interface [polypeptide binding]; other site
351746007703	putative CheW interface [polypeptide binding]; other site
351746007704	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746007705	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
351746007706	substrate binding pocket [chemical binding]; other site
351746007707	membrane-bound complex binding site; other site
351746007708	hinge residues; other site
351746007709	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746007710	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746007711	substrate binding pocket [chemical binding]; other site
351746007712	membrane-bound complex binding site; other site
351746007713	hinge residues; other site
351746007714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746007715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007716	dimer interface [polypeptide binding]; other site
351746007717	phosphorylation site [posttranslational modification]
351746007718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007719	ATP binding site [chemical binding]; other site
351746007720	Mg2+ binding site [ion binding]; other site
351746007721	G-X-G motif; other site
351746007722	Response regulator receiver domain; Region: Response_reg; pfam00072
351746007723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007724	active site
351746007725	phosphorylation site [posttranslational modification]
351746007726	intermolecular recognition site; other site
351746007727	dimerization interface [polypeptide binding]; other site
351746007728	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746007729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007730	active site
351746007731	phosphorylation site [posttranslational modification]
351746007732	intermolecular recognition site; other site
351746007733	dimerization interface [polypeptide binding]; other site
351746007734	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746007735	DNA binding residues [nucleotide binding]
351746007736	dimerization interface [polypeptide binding]; other site
351746007737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
351746007738	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
351746007739	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
351746007740	active site
351746007741	SAM binding site [chemical binding]; other site
351746007742	homodimer interface [polypeptide binding]; other site
351746007743	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
351746007744	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
351746007745	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
351746007746	putative acetyltransferase; Provisional; Region: PRK03624
351746007747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746007748	Coenzyme A binding pocket [chemical binding]; other site
351746007749	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746007750	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746007751	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746007752	Pirin-related protein [General function prediction only]; Region: COG1741
351746007753	Pirin; Region: Pirin; pfam02678
351746007754	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
351746007755	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
351746007756	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
351746007757	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
351746007758	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
351746007759	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
351746007760	Curlin associated repeat; Region: Curlin_rpt; pfam07012
351746007761	Curlin associated repeat; Region: Curlin_rpt; pfam07012
351746007762	Curlin associated repeat; Region: Curlin_rpt; pfam07012
351746007763	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
351746007764	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
351746007765	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
351746007766	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
351746007767	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
351746007768	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
351746007769	active site
351746007770	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
351746007771	catalytic core [active]
351746007772	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
351746007773	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
351746007774	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
351746007775	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746007776	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746007777	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746007778	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351746007779	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351746007780	DNA binding site [nucleotide binding]
351746007781	domain linker motif; other site
351746007782	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
351746007783	putative dimerization interface [polypeptide binding]; other site
351746007784	putative ligand binding site [chemical binding]; other site
351746007785	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
351746007786	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
351746007787	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
351746007788	substrate binding site [chemical binding]; other site
351746007789	ATP binding site [chemical binding]; other site
351746007790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007791	D-galactonate transporter; Region: 2A0114; TIGR00893
351746007792	putative substrate translocation pore; other site
351746007793	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
351746007794	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
351746007795	dimerization interface [polypeptide binding]; other site
351746007796	ligand binding site [chemical binding]; other site
351746007797	NADP binding site [chemical binding]; other site
351746007798	catalytic site [active]
351746007799	DNA-specific endonuclease I; Provisional; Region: PRK15137
351746007800	Endonuclease I; Region: Endonuclease_1; pfam04231
351746007801	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
351746007802	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746007803	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746007804	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746007805	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746007806	Surface antigen; Region: Bac_surface_Ag; pfam01103
351746007807	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746007808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007809	active site
351746007810	phosphorylation site [posttranslational modification]
351746007811	intermolecular recognition site; other site
351746007812	dimerization interface [polypeptide binding]; other site
351746007813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746007814	DNA binding site [nucleotide binding]
351746007815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746007816	HAMP domain; Region: HAMP; pfam00672
351746007817	dimerization interface [polypeptide binding]; other site
351746007818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746007819	dimer interface [polypeptide binding]; other site
351746007820	phosphorylation site [posttranslational modification]
351746007821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746007822	ATP binding site [chemical binding]; other site
351746007823	Mg2+ binding site [ion binding]; other site
351746007824	G-X-G motif; other site
351746007825	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746007826	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746007827	active site
351746007828	catalytic tetrad [active]
351746007829	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007831	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746007832	dimerization interface [polypeptide binding]; other site
351746007833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007834	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
351746007835	putative substrate translocation pore; other site
351746007836	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
351746007837	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
351746007838	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007840	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746007841	dimerization interface [polypeptide binding]; other site
351746007842	acetolactate synthase; Reviewed; Region: PRK08322
351746007843	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746007844	PYR/PP interface [polypeptide binding]; other site
351746007845	dimer interface [polypeptide binding]; other site
351746007846	TPP binding site [chemical binding]; other site
351746007847	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746007848	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
351746007849	TPP-binding site [chemical binding]; other site
351746007850	dimer interface [polypeptide binding]; other site
351746007851	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
351746007852	GAF domain; Region: GAF; pfam01590
351746007853	Phytochrome region; Region: PHY; pfam00360
351746007854	HWE histidine kinase; Region: HWE_HK; pfam07536
351746007855	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746007856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746007857	active site
351746007858	phosphorylation site [posttranslational modification]
351746007859	intermolecular recognition site; other site
351746007860	dimerization interface [polypeptide binding]; other site
351746007861	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
351746007862	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
351746007863	TMP-binding site; other site
351746007864	ATP-binding site [chemical binding]; other site
351746007865	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746007866	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
351746007867	AsnC family; Region: AsnC_trans_reg; pfam01037
351746007868	hypothetical protein; Provisional; Region: PRK06148
351746007869	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
351746007870	active site
351746007871	ATP binding site [chemical binding]; other site
351746007872	substrate binding site [chemical binding]; other site
351746007873	Peptidase family M23; Region: Peptidase_M23; pfam01551
351746007874	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746007875	inhibitor-cofactor binding pocket; inhibition site
351746007876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746007877	catalytic residue [active]
351746007878	mechanosensitive channel MscS; Provisional; Region: PRK10334
351746007879	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746007880	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351746007881	MarR family; Region: MarR_2; pfam12802
351746007882	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
351746007883	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746007884	substrate binding site [chemical binding]; other site
351746007885	oxyanion hole (OAH) forming residues; other site
351746007886	trimer interface [polypeptide binding]; other site
351746007887	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746007888	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
351746007889	NAD(P) binding site [chemical binding]; other site
351746007890	catalytic residues [active]
351746007891	feruloyl-CoA synthase; Reviewed; Region: PRK08180
351746007892	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
351746007893	acyl-activating enzyme (AAE) consensus motif; other site
351746007894	putative AMP binding site [chemical binding]; other site
351746007895	putative active site [active]
351746007896	putative CoA binding site [chemical binding]; other site
351746007897	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746007898	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
351746007899	dimer interface [polypeptide binding]; other site
351746007900	active site
351746007901	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746007902	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746007903	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746007904	active site
351746007905	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746007906	Uncharacterized conserved protein [Function unknown]; Region: COG1262
351746007907	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
351746007908	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
351746007909	Sulfatase; Region: Sulfatase; pfam00884
351746007910	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
351746007911	benzoate transport; Region: 2A0115; TIGR00895
351746007912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007913	putative substrate translocation pore; other site
351746007914	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746007915	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746007916	metal binding site [ion binding]; metal-binding site
351746007917	active site
351746007918	I-site; other site
351746007919	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
351746007920	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746007921	N-terminal plug; other site
351746007922	ligand-binding site [chemical binding]; other site
351746007923	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746007924	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746007925	N-terminal plug; other site
351746007926	ligand-binding site [chemical binding]; other site
351746007927	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
351746007928	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746007929	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746007930	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746007931	dimerization interface [polypeptide binding]; other site
351746007932	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746007933	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
351746007934	putative metal binding site [ion binding]; other site
351746007935	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
351746007936	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746007937	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
351746007938	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746007939	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746007940	N-terminal plug; other site
351746007941	ligand-binding site [chemical binding]; other site
351746007942	putative GTP cyclohydrolase; Provisional; Region: PRK13674
351746007943	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
351746007944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746007945	putative substrate translocation pore; other site
351746007946	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
351746007947	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
351746007948	dimer interface [polypeptide binding]; other site
351746007949	active site
351746007950	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
351746007951	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746007952	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746007953	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746007954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746007955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746007956	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
351746007957	short chain dehydrogenase; Provisional; Region: PRK06139
351746007958	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
351746007959	putative NAD(P) binding site [chemical binding]; other site
351746007960	active site
351746007961	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
351746007962	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
351746007963	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
351746007964	NAD binding site [chemical binding]; other site
351746007965	catalytic Zn binding site [ion binding]; other site
351746007966	structural Zn binding site [ion binding]; other site
351746007967	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
351746007968	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
351746007969	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
351746007970	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
351746007971	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
351746007972	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
351746007973	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
351746007974	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
351746007975	thiamine pyrophosphate protein; Provisional; Region: PRK08273
351746007976	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
351746007977	PYR/PP interface [polypeptide binding]; other site
351746007978	dimer interface [polypeptide binding]; other site
351746007979	tetramer interface [polypeptide binding]; other site
351746007980	TPP binding site [chemical binding]; other site
351746007981	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746007982	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
351746007983	TPP-binding site [chemical binding]; other site
351746007984	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
351746007985	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
351746007986	hypothetical protein; Provisional; Region: PRK09256
351746007987	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
351746007988	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746007989	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746007990	substrate binding pocket [chemical binding]; other site
351746007991	membrane-bound complex binding site; other site
351746007992	hinge residues; other site
351746007993	putrescine transporter; Provisional; Region: potE; PRK10655
351746007994	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
351746007995	Predicted transporter component [General function prediction only]; Region: COG2391
351746007996	Sulphur transport; Region: Sulf_transp; pfam04143
351746007997	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
351746007998	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
351746007999	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
351746008000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008001	Ligand Binding Site [chemical binding]; other site
351746008002	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008003	Ligand Binding Site [chemical binding]; other site
351746008004	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008005	Ligand Binding Site [chemical binding]; other site
351746008006	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
351746008007	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746008008	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351746008009	Hemerythrin-like domain; Region: Hr-like; cd12108
351746008010	Fe binding site [ion binding]; other site
351746008011	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
351746008012	BON domain; Region: BON; pfam04972
351746008013	BON domain; Region: BON; pfam04972
351746008014	BON domain; Region: BON; pfam04972
351746008015	FtsH Extracellular; Region: FtsH_ext; pfam06480
351746008016	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
351746008017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746008018	Walker A motif; other site
351746008019	ATP binding site [chemical binding]; other site
351746008020	Walker B motif; other site
351746008021	arginine finger; other site
351746008022	Peptidase family M41; Region: Peptidase_M41; pfam01434
351746008023	Ion channel; Region: Ion_trans_2; pfam07885
351746008024	putative phosphoketolase; Provisional; Region: PRK05261
351746008025	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
351746008026	TPP-binding site; other site
351746008027	XFP C-terminal domain; Region: XFP_C; pfam09363
351746008028	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
351746008029	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
351746008030	putative dimer interface [polypeptide binding]; other site
351746008031	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351746008032	ligand binding site [chemical binding]; other site
351746008033	flexible hinge region; other site
351746008034	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
351746008035	putative switch regulator; other site
351746008036	non-specific DNA interactions [nucleotide binding]; other site
351746008037	DNA binding site [nucleotide binding]
351746008038	sequence specific DNA binding site [nucleotide binding]; other site
351746008039	putative cAMP binding site [chemical binding]; other site
351746008040	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
351746008041	Protein of unknown function, DUF399; Region: DUF399; cl01139
351746008042	Erythromycin esterase; Region: Erythro_esteras; pfam05139
351746008043	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746008044	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
351746008045	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351746008046	Beta-Casp domain; Region: Beta-Casp; smart01027
351746008047	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
351746008048	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008049	Ligand Binding Site [chemical binding]; other site
351746008050	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746008051	Coenzyme A binding pocket [chemical binding]; other site
351746008052	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008053	Ligand Binding Site [chemical binding]; other site
351746008054	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
351746008055	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351746008056	ligand binding site [chemical binding]; other site
351746008057	flexible hinge region; other site
351746008058	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
351746008059	putative switch regulator; other site
351746008060	non-specific DNA interactions [nucleotide binding]; other site
351746008061	DNA binding site [nucleotide binding]
351746008062	sequence specific DNA binding site [nucleotide binding]; other site
351746008063	putative cAMP binding site [chemical binding]; other site
351746008064	Predicted membrane protein [Function unknown]; Region: COG3174
351746008065	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
351746008066	PaaX-like protein; Region: PaaX; pfam07848
351746008067	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
351746008068	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
351746008069	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
351746008070	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
351746008071	putative trimer interface [polypeptide binding]; other site
351746008072	putative metal binding site [ion binding]; other site
351746008073	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
351746008074	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746008075	substrate binding site [chemical binding]; other site
351746008076	oxyanion hole (OAH) forming residues; other site
351746008077	trimer interface [polypeptide binding]; other site
351746008078	enoyl-CoA hydratase; Provisional; Region: PRK08140
351746008079	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746008080	substrate binding site [chemical binding]; other site
351746008081	oxyanion hole (OAH) forming residues; other site
351746008082	trimer interface [polypeptide binding]; other site
351746008083	3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279
351746008084	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
351746008085	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746008086	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746008087	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
351746008088	CoenzymeA binding site [chemical binding]; other site
351746008089	subunit interaction site [polypeptide binding]; other site
351746008090	PHB binding site; other site
351746008091	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
351746008092	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746008093	dimer interface [polypeptide binding]; other site
351746008094	active site
351746008095	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
351746008096	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
351746008097	active site
351746008098	AMP binding site [chemical binding]; other site
351746008099	homodimer interface [polypeptide binding]; other site
351746008100	acyl-activating enzyme (AAE) consensus motif; other site
351746008101	CoA binding site [chemical binding]; other site
351746008102	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
351746008103	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
351746008104	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
351746008105	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
351746008106	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
351746008107	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
351746008108	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
351746008109	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
351746008110	FAD binding pocket [chemical binding]; other site
351746008111	FAD binding motif [chemical binding]; other site
351746008112	phosphate binding motif [ion binding]; other site
351746008113	beta-alpha-beta structure motif; other site
351746008114	NAD(p) ribose binding residues [chemical binding]; other site
351746008115	NAD binding pocket [chemical binding]; other site
351746008116	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
351746008117	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746008118	catalytic loop [active]
351746008119	iron binding site [ion binding]; other site
351746008120	Protein of unknown function, DUF485; Region: DUF485; pfam04341
351746008121	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
351746008122	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
351746008123	Na binding site [ion binding]; other site
351746008124	outer membrane porin, OprD family; Region: OprD; pfam03573
351746008125	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
351746008126	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
351746008127	substrate binding site [chemical binding]; other site
351746008128	dimer interface [polypeptide binding]; other site
351746008129	NADP binding site [chemical binding]; other site
351746008130	catalytic residues [active]
351746008131	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
351746008132	substrate binding site [chemical binding]; other site
351746008133	General stress protein [General function prediction only]; Region: GsiB; COG3729
351746008134	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
351746008135	nudix motif; other site
351746008136	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
351746008137	active site
351746008138	Protein of unknown function DUF72; Region: DUF72; pfam01904
351746008139	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
351746008140	putative catalytic site [active]
351746008141	putative metal binding site [ion binding]; other site
351746008142	putative phosphate binding site [ion binding]; other site
351746008143	cardiolipin synthase 2; Provisional; Region: PRK11263
351746008144	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
351746008145	putative active site [active]
351746008146	catalytic site [active]
351746008147	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
351746008148	putative active site [active]
351746008149	catalytic site [active]
351746008150	Predicted integral membrane protein [Function unknown]; Region: COG0392
351746008151	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
351746008152	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
351746008153	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
351746008154	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
351746008155	active site
351746008156	DNA binding site [nucleotide binding]
351746008157	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
351746008158	DNA binding site [nucleotide binding]
351746008159	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
351746008160	nucleotide binding site [chemical binding]; other site
351746008161	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746008162	active site
351746008163	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746008164	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
351746008165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351746008166	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351746008167	active site
351746008168	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
351746008169	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
351746008170	putative DNA binding site [nucleotide binding]; other site
351746008171	putative homodimer interface [polypeptide binding]; other site
351746008172	nucleosidase; Provisional; Region: PRK05634
351746008173	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
351746008174	carboxylate-amine ligase; Provisional; Region: PRK13515
351746008175	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
351746008176	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
351746008177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746008178	S-adenosylmethionine binding site [chemical binding]; other site
351746008179	TLC ATP/ADP transporter; Region: TLC; cl03940
351746008180	TLC ATP/ADP transporter; Region: TLC; cl03940
351746008181	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746008182	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746008183	active site
351746008184	catalytic tetrad [active]
351746008185	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
351746008186	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
351746008187	Sodium Bile acid symporter family; Region: SBF; pfam01758
351746008188	beta-carotene hydroxylase; Region: PLN02601
351746008189	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
351746008190	MgtC family; Region: MgtC; pfam02308
351746008191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746008192	Coenzyme A binding pocket [chemical binding]; other site
351746008193	Cache domain; Region: Cache_1; pfam02743
351746008194	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746008195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746008196	metal binding site [ion binding]; metal-binding site
351746008197	active site
351746008198	I-site; other site
351746008199	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
351746008200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746008201	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
351746008202	Inter-alpha-trypsin inhibitor heavy chain C-terminus; Region: ITI_HC_C; pfam06668
351746008203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
351746008204	YheO-like PAS domain; Region: PAS_6; pfam08348
351746008205	HTH domain; Region: HTH_22; pfam13309
351746008206	hypothetical protein; Provisional; Region: PRK06815
351746008207	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
351746008208	tetramer interface [polypeptide binding]; other site
351746008209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746008210	catalytic residue [active]
351746008211	ornithine cyclodeaminase; Validated; Region: PRK06823
351746008212	ectoine utilization protein EutC; Validated; Region: PRK08291
351746008213	cytosine deaminase; Provisional; Region: PRK09230
351746008214	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
351746008215	active site
351746008216	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
351746008217	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
351746008218	cytosine permease; Provisional; Region: codB; PRK11017
351746008219	Na binding site [ion binding]; other site
351746008220	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
351746008221	Putative transcription activator [Transcription]; Region: TenA; COG0819
351746008222	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
351746008223	Transcription factor PAP1; Region: PAP1; pfam08601
351746008224	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
351746008225	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
351746008226	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
351746008227	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
351746008228	Cu(I) binding site [ion binding]; other site
351746008229	Cytochrome c; Region: Cytochrom_C; pfam00034
351746008230	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746008231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746008232	metal binding site [ion binding]; metal-binding site
351746008233	active site
351746008234	I-site; other site
351746008235	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746008236	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
351746008237	DNA binding site [nucleotide binding]
351746008238	dimer interface [polypeptide binding]; other site
351746008239	active site
351746008240	Int/Topo IB signature motif; other site
351746008241	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
351746008242	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
351746008243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008244	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
351746008245	dimerization interface [polypeptide binding]; other site
351746008246	substrate binding pocket [chemical binding]; other site
351746008247	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
351746008248	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
351746008249	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
351746008250	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
351746008251	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
351746008252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008253	putative substrate translocation pore; other site
351746008254	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
351746008255	[2Fe-2S] cluster binding site [ion binding]; other site
351746008256	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
351746008257	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746008258	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746008259	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746008260	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746008261	active site
351746008262	catalytic tetrad [active]
351746008263	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
351746008264	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
351746008265	FMN binding site [chemical binding]; other site
351746008266	active site
351746008267	substrate binding site [chemical binding]; other site
351746008268	catalytic residue [active]
351746008269	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
351746008270	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
351746008271	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
351746008272	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008273	LysR family transcriptional regulator; Provisional; Region: PRK14997
351746008274	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746008275	putative effector binding pocket; other site
351746008276	dimerization interface [polypeptide binding]; other site
351746008277	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
351746008278	outer membrane porin, OprD family; Region: OprD; pfam03573
351746008279	Benzoate membrane transport protein; Region: BenE; pfam03594
351746008280	benzoate transporter; Region: benE; TIGR00843
351746008281	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
351746008282	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
351746008283	dimer interface [polypeptide binding]; other site
351746008284	active site
351746008285	benzoate transport; Region: 2A0115; TIGR00895
351746008286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008287	putative substrate translocation pore; other site
351746008288	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
351746008289	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
351746008290	putative NAD(P) binding site [chemical binding]; other site
351746008291	active site
351746008292	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
351746008293	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746008294	catalytic loop [active]
351746008295	iron binding site [ion binding]; other site
351746008296	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
351746008297	FAD binding pocket [chemical binding]; other site
351746008298	FAD binding motif [chemical binding]; other site
351746008299	phosphate binding motif [ion binding]; other site
351746008300	beta-alpha-beta structure motif; other site
351746008301	NAD binding pocket [chemical binding]; other site
351746008302	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
351746008303	inter-subunit interface; other site
351746008304	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
351746008305	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
351746008306	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
351746008307	putative alpha subunit interface [polypeptide binding]; other site
351746008308	putative active site [active]
351746008309	putative substrate binding site [chemical binding]; other site
351746008310	Fe binding site [ion binding]; other site
351746008311	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746008312	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746008313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008314	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
351746008315	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
351746008316	active site
351746008317	universal stress protein UspE; Provisional; Region: PRK11175
351746008318	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008319	Ligand Binding Site [chemical binding]; other site
351746008320	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746008321	Ligand Binding Site [chemical binding]; other site
351746008322	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746008323	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746008324	N-terminal plug; other site
351746008325	ligand-binding site [chemical binding]; other site
351746008326	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
351746008327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008329	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
351746008330	putative dimerization interface [polypeptide binding]; other site
351746008331	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
351746008332	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
351746008333	NAD(P) binding site [chemical binding]; other site
351746008334	catalytic residues [active]
351746008335	AAA domain; Region: AAA_30; pfam13604
351746008336	Helix-turn-helix domain; Region: HTH_18; pfam12833
351746008337	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746008338	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746008339	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746008340	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746008341	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746008342	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746008343	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
351746008344	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
351746008345	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
351746008346	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
351746008347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008348	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746008349	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746008350	dimerization interface [polypeptide binding]; other site
351746008351	substrate binding pocket [chemical binding]; other site
351746008352	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
351746008353	Bacterial sugar transferase; Region: Bac_transf; pfam02397
351746008354	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
351746008355	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746008356	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
351746008357	DXD motif; other site
351746008358	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
351746008359	putative ADP-binding pocket [chemical binding]; other site
351746008360	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746008361	Protein of unknown function (DUF535); Region: DUF535; pfam04393
351746008362	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746008363	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351746008364	active site
351746008365	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
351746008366	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
351746008367	trimer interface [polypeptide binding]; other site
351746008368	active site
351746008369	substrate binding site [chemical binding]; other site
351746008370	CoA binding site [chemical binding]; other site
351746008371	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
351746008372	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
351746008373	Probable Catalytic site; other site
351746008374	metal-binding site
351746008375	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
351746008376	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
351746008377	trimer interface [polypeptide binding]; other site
351746008378	active site
351746008379	substrate binding site [chemical binding]; other site
351746008380	CoA binding site [chemical binding]; other site
351746008381	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
351746008382	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
351746008383	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
351746008384	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
351746008385	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
351746008386	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
351746008387	NAD binding site [chemical binding]; other site
351746008388	homodimer interface [polypeptide binding]; other site
351746008389	active site
351746008390	substrate binding site [chemical binding]; other site
351746008391	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
351746008392	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
351746008393	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
351746008394	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
351746008395	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
351746008396	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746008397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746008398	non-specific DNA binding site [nucleotide binding]; other site
351746008399	salt bridge; other site
351746008400	sequence-specific DNA binding site [nucleotide binding]; other site
351746008401	Cupin domain; Region: Cupin_2; pfam07883
351746008402	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
351746008403	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
351746008404	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
351746008405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008407	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
351746008408	putative dimerization interface [polypeptide binding]; other site
351746008409	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746008410	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746008411	active site
351746008412	catalytic tetrad [active]
351746008413	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351746008414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351746008415	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351746008416	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
351746008417	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
351746008418	putative active site [active]
351746008419	putative PHP Thumb interface [polypeptide binding]; other site
351746008420	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
351746008421	generic binding surface I; other site
351746008422	generic binding surface II; other site
351746008423	DNA Polymerase Y-family; Region: PolY_like; cd03468
351746008424	active site
351746008425	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
351746008426	DNA binding site [nucleotide binding]
351746008427	Uncharacterized conserved protein [Function unknown]; Region: COG4544
351746008428	LexA repressor; Provisional; Region: PRK12423
351746008429	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
351746008430	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746008431	Catalytic site [active]
351746008432	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
351746008433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746008434	motif II; other site
351746008435	benzoate transport; Region: 2A0115; TIGR00895
351746008436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008437	putative substrate translocation pore; other site
351746008438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008439	NIPSNAP; Region: NIPSNAP; pfam07978
351746008440	putative succinate dehydrogenase; Reviewed; Region: PRK12842
351746008441	Predicted oxidoreductase [General function prediction only]; Region: COG3573
351746008442	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
351746008443	classical (c) SDRs; Region: SDR_c; cd05233
351746008444	NAD(P) binding site [chemical binding]; other site
351746008445	active site
351746008446	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
351746008447	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008448	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
351746008449	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351746008450	amidase; Provisional; Region: PRK07486
351746008451	Amidase; Region: Amidase; cl11426
351746008452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008453	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746008454	putative substrate translocation pore; other site
351746008455	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
351746008456	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
351746008457	metal binding site [ion binding]; metal-binding site
351746008458	putative dimer interface [polypeptide binding]; other site
351746008459	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
351746008460	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
351746008461	RHS Repeat; Region: RHS_repeat; pfam05593
351746008462	RHS Repeat; Region: RHS_repeat; cl11982
351746008463	RHS Repeat; Region: RHS_repeat; cl11982
351746008464	RHS protein; Region: RHS; pfam03527
351746008465	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746008466	Pput_2613-like deaminase; Region: Pput2613-deam; pfam14427
351746008467	PAAR motif; Region: PAAR_motif; pfam05488
351746008468	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
351746008469	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
351746008470	RHS Repeat; Region: RHS_repeat; cl11982
351746008471	RHS Repeat; Region: RHS_repeat; pfam05593
351746008472	RHS protein; Region: RHS; pfam03527
351746008473	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746008474	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
351746008475	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
351746008476	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
351746008477	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
351746008478	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
351746008479	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
351746008480	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
351746008481	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
351746008482	Protein of unknown function (DUF770); Region: DUF770; pfam05591
351746008483	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
351746008484	Protein of unknown function (DUF877); Region: DUF877; pfam05943
351746008485	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
351746008486	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
351746008487	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
351746008488	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
351746008489	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
351746008490	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746008491	Walker A motif; other site
351746008492	ATP binding site [chemical binding]; other site
351746008493	Walker B motif; other site
351746008494	arginine finger; other site
351746008495	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746008496	Walker A motif; other site
351746008497	ATP binding site [chemical binding]; other site
351746008498	Walker B motif; other site
351746008499	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
351746008500	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
351746008501	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
351746008502	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
351746008503	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
351746008504	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
351746008505	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
351746008506	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
351746008507	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
351746008508	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
351746008509	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
351746008510	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746008511	ligand binding site [chemical binding]; other site
351746008512	Protein of unknown function (DUF796); Region: DUF796; pfam05638
351746008513	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
351746008514	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
351746008515	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
351746008516	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
351746008517	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
351746008518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746008519	Walker A/P-loop; other site
351746008520	ATP binding site [chemical binding]; other site
351746008521	Q-loop/lid; other site
351746008522	ABC transporter signature motif; other site
351746008523	Walker B; other site
351746008524	D-loop; other site
351746008525	H-loop/switch region; other site
351746008526	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
351746008527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008528	putative substrate translocation pore; other site
351746008529	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
351746008530	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746008531	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746008532	Predicted permeases [General function prediction only]; Region: COG0679
351746008533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008534	putative substrate translocation pore; other site
351746008535	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746008536	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
351746008537	substrate binding site [chemical binding]; other site
351746008538	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
351746008539	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
351746008540	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
351746008541	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
351746008542	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
351746008543	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
351746008544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746008545	dimer interface [polypeptide binding]; other site
351746008546	conserved gate region; other site
351746008547	putative PBP binding loops; other site
351746008548	ABC-ATPase subunit interface; other site
351746008549	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
351746008550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746008551	dimer interface [polypeptide binding]; other site
351746008552	conserved gate region; other site
351746008553	putative PBP binding loops; other site
351746008554	ABC-ATPase subunit interface; other site
351746008555	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
351746008556	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746008557	Walker B motif; other site
351746008558	arginine finger; other site
351746008559	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746008560	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
351746008561	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
351746008562	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
351746008563	NAD binding site [chemical binding]; other site
351746008564	homotetramer interface [polypeptide binding]; other site
351746008565	homodimer interface [polypeptide binding]; other site
351746008566	substrate binding site [chemical binding]; other site
351746008567	active site
351746008568	ecotin; Provisional; Region: PRK03719
351746008569	secondary substrate binding site; other site
351746008570	primary substrate binding site; other site
351746008571	inhibition loop; other site
351746008572	dimerization interface [polypeptide binding]; other site
351746008573	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
351746008574	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
351746008575	acyl-activating enzyme (AAE) consensus motif; other site
351746008576	putative AMP binding site [chemical binding]; other site
351746008577	putative active site [active]
351746008578	putative CoA binding site [chemical binding]; other site
351746008579	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
351746008580	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
351746008581	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
351746008582	Autotransporter beta-domain; Region: Autotransporter; smart00869
351746008583	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746008584	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746008585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008586	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746008587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008588	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746008589	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
351746008590	active site
351746008591	metal binding site [ion binding]; metal-binding site
351746008592	Predicted amidohydrolase [General function prediction only]; Region: COG0388
351746008593	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
351746008594	active site
351746008595	catalytic triad [active]
351746008596	dimer interface [polypeptide binding]; other site
351746008597	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
351746008598	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
351746008599	DNA binding site [nucleotide binding]
351746008600	active site
351746008601	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
351746008602	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
351746008603	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746008604	acyl-activating enzyme (AAE) consensus motif; other site
351746008605	AMP binding site [chemical binding]; other site
351746008606	active site
351746008607	CoA binding site [chemical binding]; other site
351746008608	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746008609	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
351746008610	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746008611	active site
351746008612	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746008613	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
351746008614	Protein export membrane protein; Region: SecD_SecF; cl14618
351746008615	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
351746008616	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
351746008617	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
351746008618	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
351746008619	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746008620	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746008621	SurA N-terminal domain; Region: SurA_N; pfam09312
351746008622	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746008623	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008624	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
351746008625	iron-sulfur cluster [ion binding]; other site
351746008626	[2Fe-2S] cluster binding site [ion binding]; other site
351746008627	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
351746008628	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
351746008629	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
351746008630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008631	putative substrate translocation pore; other site
351746008632	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
351746008633	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
351746008634	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
351746008635	substrate binding pocket [chemical binding]; other site
351746008636	active site
351746008637	iron coordination sites [ion binding]; other site
351746008638	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
351746008639	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
351746008640	NADP binding site [chemical binding]; other site
351746008641	dimer interface [polypeptide binding]; other site
351746008642	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
351746008643	RNA polymerase sigma factor; Provisional; Region: PRK12537
351746008644	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746008645	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746008646	DNA binding residues [nucleotide binding]
351746008647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
351746008648	Anti-sigma-K factor rskA; Region: RskA; pfam10099
351746008649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008650	putative substrate translocation pore; other site
351746008651	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008652	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
351746008653	Dehydroquinase class II; Region: DHquinase_II; pfam01220
351746008654	trimer interface [polypeptide binding]; other site
351746008655	active site
351746008656	dimer interface [polypeptide binding]; other site
351746008657	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
351746008658	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
351746008659	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
351746008660	shikimate binding site; other site
351746008661	NAD(P) binding site [chemical binding]; other site
351746008662	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
351746008663	CoA-transferase family III; Region: CoA_transf_3; pfam02515
351746008664	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
351746008665	active site
351746008666	catalytic site [active]
351746008667	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746008668	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
351746008669	active site
351746008670	metal binding site [ion binding]; metal-binding site
351746008671	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
351746008672	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
351746008673	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
351746008674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008676	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
351746008677	substrate binding pocket [chemical binding]; other site
351746008678	dimerization interface [polypeptide binding]; other site
351746008679	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
351746008680	classical (c) SDRs; Region: SDR_c; cd05233
351746008681	NAD(P) binding site [chemical binding]; other site
351746008682	active site
351746008683	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
351746008684	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
351746008685	putative active site [active]
351746008686	putative FMN binding site [chemical binding]; other site
351746008687	putative substrate binding site [chemical binding]; other site
351746008688	putative catalytic residue [active]
351746008689	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
351746008690	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
351746008691	potential catalytic triad [active]
351746008692	conserved cys residue [active]
351746008693	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
351746008694	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
351746008695	DNA binding residues [nucleotide binding]
351746008696	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
351746008697	classical (c) SDRs; Region: SDR_c; cd05233
351746008698	NAD(P) binding site [chemical binding]; other site
351746008699	active site
351746008700	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
351746008701	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
351746008702	putative NAD(P) binding site [chemical binding]; other site
351746008703	Predicted transcriptional regulators [Transcription]; Region: COG1733
351746008704	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
351746008705	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746008708	dimerization interface [polypeptide binding]; other site
351746008709	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
351746008710	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
351746008711	putative NADP binding site [chemical binding]; other site
351746008712	putative substrate binding site [chemical binding]; other site
351746008713	active site
351746008714	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
351746008715	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
351746008716	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
351746008717	putative NAD(P) binding site [chemical binding]; other site
351746008718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008720	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746008721	putative effector binding pocket; other site
351746008722	dimerization interface [polypeptide binding]; other site
351746008723	Cupin; Region: Cupin_6; pfam12852
351746008724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008725	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746008726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008727	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
351746008728	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
351746008729	GSH binding site [chemical binding]; other site
351746008730	catalytic residues [active]
351746008731	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
351746008732	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
351746008733	Peptidase_C39 like family; Region: DUF3335; pfam11814
351746008734	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
351746008735	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
351746008736	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351746008737	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
351746008738	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
351746008739	Cl binding site [ion binding]; other site
351746008740	oligomer interface [polypeptide binding]; other site
351746008741	Uncharacterized conserved protein [Function unknown]; Region: COG1359
351746008742	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
351746008743	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
351746008744	putative NAD(P) binding site [chemical binding]; other site
351746008745	dimer interface [polypeptide binding]; other site
351746008746	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008747	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008748	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746008749	putative effector binding pocket; other site
351746008750	dimerization interface [polypeptide binding]; other site
351746008751	putative transcriptional regulator; Provisional; Region: PRK11640
351746008752	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746008753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
351746008754	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
351746008755	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746008756	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
351746008757	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
351746008758	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
351746008759	heme-binding site [chemical binding]; other site
351746008760	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
351746008761	amidase; Provisional; Region: PRK07235
351746008762	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
351746008763	putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351
351746008764	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
351746008765	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
351746008766	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
351746008767	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
351746008768	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
351746008769	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
351746008770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
351746008771	PAS fold; Region: PAS_3; pfam08447
351746008772	heme pocket [chemical binding]; other site
351746008773	putative active site [active]
351746008774	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746008775	PAS fold; Region: PAS_3; pfam08447
351746008776	putative active site [active]
351746008777	heme pocket [chemical binding]; other site
351746008778	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351746008779	EamA-like transporter family; Region: EamA; pfam00892
351746008780	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746008781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746008782	DNA-binding site [nucleotide binding]; DNA binding site
351746008783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746008784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746008785	homodimer interface [polypeptide binding]; other site
351746008786	catalytic residue [active]
351746008787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746008788	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
351746008789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746008790	dimer interface [polypeptide binding]; other site
351746008791	phosphorylation site [posttranslational modification]
351746008792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746008793	ATP binding site [chemical binding]; other site
351746008794	Mg2+ binding site [ion binding]; other site
351746008795	G-X-G motif; other site
351746008796	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746008797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746008798	active site
351746008799	phosphorylation site [posttranslational modification]
351746008800	intermolecular recognition site; other site
351746008801	dimerization interface [polypeptide binding]; other site
351746008802	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746008803	DNA binding site [nucleotide binding]
351746008804	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
351746008805	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
351746008806	Flavodoxin; Region: Flavodoxin_1; pfam00258
351746008807	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
351746008808	FAD binding pocket [chemical binding]; other site
351746008809	FAD binding motif [chemical binding]; other site
351746008810	catalytic residues [active]
351746008811	NAD binding pocket [chemical binding]; other site
351746008812	phosphate binding motif [ion binding]; other site
351746008813	beta-alpha-beta structure motif; other site
351746008814	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
351746008815	ApbE family; Region: ApbE; pfam02424
351746008816	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
351746008817	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351746008818	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746008819	Coenzyme A binding pocket [chemical binding]; other site
351746008820	Response regulator receiver domain; Region: Response_reg; pfam00072
351746008821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746008822	active site
351746008823	phosphorylation site [posttranslational modification]
351746008824	intermolecular recognition site; other site
351746008825	dimerization interface [polypeptide binding]; other site
351746008826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
351746008827	dimer interface [polypeptide binding]; other site
351746008828	phosphorylation site [posttranslational modification]
351746008829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746008830	ATP binding site [chemical binding]; other site
351746008831	Mg2+ binding site [ion binding]; other site
351746008832	G-X-G motif; other site
351746008833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746008834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746008835	ATP binding site [chemical binding]; other site
351746008836	Mg2+ binding site [ion binding]; other site
351746008837	G-X-G motif; other site
351746008838	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
351746008839	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
351746008840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746008841	active site
351746008842	phosphorylation site [posttranslational modification]
351746008843	intermolecular recognition site; other site
351746008844	dimerization interface [polypeptide binding]; other site
351746008845	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351746008846	Zn2+ binding site [ion binding]; other site
351746008847	Mg2+ binding site [ion binding]; other site
351746008848	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
351746008849	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
351746008850	HTH domain; Region: HTH_11; pfam08279
351746008851	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
351746008852	diaminopimelate epimerase; Provisional; Region: PRK13577
351746008853	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
351746008854	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
351746008855	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
351746008856	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
351746008857	OsmC-like protein; Region: OsmC; cl00767
351746008858	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
351746008859	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746008860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746008861	Walker A/P-loop; other site
351746008862	ATP binding site [chemical binding]; other site
351746008863	ABC transporter signature motif; other site
351746008864	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746008865	Walker B; other site
351746008866	ABC transporter; Region: ABC_tran_2; pfam12848
351746008867	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746008868	major facilitator superfamily transporter; Provisional; Region: PRK05122
351746008869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008870	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
351746008871	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746008872	putative S-transferase; Provisional; Region: PRK11752
351746008873	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
351746008874	C-terminal domain interface [polypeptide binding]; other site
351746008875	GSH binding site (G-site) [chemical binding]; other site
351746008876	dimer interface [polypeptide binding]; other site
351746008877	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
351746008878	dimer interface [polypeptide binding]; other site
351746008879	N-terminal domain interface [polypeptide binding]; other site
351746008880	active site
351746008881	amidase; Validated; Region: PRK06565
351746008882	Amidase; Region: Amidase; cl11426
351746008883	Amidase; Region: Amidase; cl11426
351746008884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
351746008885	YheO-like PAS domain; Region: PAS_6; pfam08348
351746008886	HTH domain; Region: HTH_22; pfam13309
351746008887	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
351746008888	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
351746008889	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746008890	catalytic residue [active]
351746008891	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
351746008892	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
351746008893	dimer interface [polypeptide binding]; other site
351746008894	active site
351746008895	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746008896	catalytic residues [active]
351746008897	substrate binding site [chemical binding]; other site
351746008898	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
351746008899	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
351746008900	NAD(P) binding pocket [chemical binding]; other site
351746008901	Methyltransferase domain; Region: Methyltransf_31; pfam13847
351746008902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746008903	S-adenosylmethionine binding site [chemical binding]; other site
351746008904	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
351746008905	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
351746008906	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
351746008907	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
351746008908	malate:quinone oxidoreductase; Validated; Region: PRK05257
351746008909	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
351746008910	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
351746008911	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746008912	FeS/SAM binding site; other site
351746008913	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
351746008914	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
351746008915	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
351746008916	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
351746008917	hypothetical protein; Provisional; Region: PRK12569
351746008918	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746008919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746008920	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
351746008921	putative substrate binding pocket [chemical binding]; other site
351746008922	dimerization interface [polypeptide binding]; other site
351746008923	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
351746008924	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
351746008925	Lumazine binding domain; Region: Lum_binding; pfam00677
351746008926	Lumazine binding domain; Region: Lum_binding; pfam00677
351746008927	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
351746008928	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
351746008929	proline/glycine betaine transporter; Provisional; Region: PRK10642
351746008930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746008931	putative substrate translocation pore; other site
351746008932	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
351746008933	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
351746008934	dimer interface [polypeptide binding]; other site
351746008935	active site
351746008936	Schiff base residues; other site
351746008937	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
351746008938	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
351746008939	ATP binding site [chemical binding]; other site
351746008940	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
351746008941	Spore germination protein; Region: Spore_permease; cl17796
351746008942	Predicted dehydrogenase [General function prediction only]; Region: COG0579
351746008943	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351746008944	carbon starvation induced protein; Validated; Region: PRK02963
351746008945	substrate binding pocket [chemical binding]; other site
351746008946	active site
351746008947	iron coordination sites [ion binding]; other site
351746008948	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
351746008949	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746008950	DNA-binding site [nucleotide binding]; DNA binding site
351746008951	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746008952	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746008953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746008954	active site
351746008955	phosphorylation site [posttranslational modification]
351746008956	intermolecular recognition site; other site
351746008957	dimerization interface [polypeptide binding]; other site
351746008958	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746008959	DNA binding site [nucleotide binding]
351746008960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746008961	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746008962	dimerization interface [polypeptide binding]; other site
351746008963	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746008964	dimer interface [polypeptide binding]; other site
351746008965	phosphorylation site [posttranslational modification]
351746008966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746008967	ATP binding site [chemical binding]; other site
351746008968	Mg2+ binding site [ion binding]; other site
351746008969	G-X-G motif; other site
351746008970	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
351746008971	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
351746008972	active site
351746008973	HIGH motif; other site
351746008974	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
351746008975	KMSKS motif; other site
351746008976	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
351746008977	tRNA binding surface [nucleotide binding]; other site
351746008978	anticodon binding site; other site
351746008979	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
351746008980	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
351746008981	active site
351746008982	HIGH motif; other site
351746008983	nucleotide binding site [chemical binding]; other site
351746008984	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
351746008985	KMSKS motif; other site
351746008986	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
351746008987	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
351746008988	substrate binding site [chemical binding]; other site
351746008989	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
351746008990	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
351746008991	putative active site [active]
351746008992	putative metal binding site [ion binding]; other site
351746008993	Penicillin amidase; Region: Penicil_amidase; pfam01804
351746008994	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
351746008995	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
351746008996	active site
351746008997	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
351746008998	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
351746008999	Mor transcription activator family; Region: Mor; cl02360
351746009000	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
351746009001	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
351746009002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
351746009003	Family of unknown function (DUF490); Region: DUF490; pfam04357
351746009004	Family of unknown function (DUF490); Region: DUF490; pfam04357
351746009005	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
351746009006	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746009007	Surface antigen; Region: Bac_surface_Ag; pfam01103
351746009008	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
351746009009	Coenzyme A binding pocket [chemical binding]; other site
351746009010	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
351746009011	putative catalytic site [active]
351746009012	putative phosphate binding site [ion binding]; other site
351746009013	active site
351746009014	metal binding site A [ion binding]; metal-binding site
351746009015	DNA binding site [nucleotide binding]
351746009016	putative AP binding site [nucleotide binding]; other site
351746009017	putative metal binding site B [ion binding]; other site
351746009018	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
351746009019	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
351746009020	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746009021	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746009022	DNA binding residues [nucleotide binding]
351746009023	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
351746009024	putative heme binding pocket [chemical binding]; other site
351746009025	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
351746009026	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746009027	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
351746009028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746009029	non-specific DNA binding site [nucleotide binding]; other site
351746009030	salt bridge; other site
351746009031	sequence-specific DNA binding site [nucleotide binding]; other site
351746009032	Cupin domain; Region: Cupin_2; pfam07883
351746009033	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
351746009034	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
351746009035	putative catalytic residue [active]
351746009036	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
351746009037	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
351746009038	putative NAD(P) binding site [chemical binding]; other site
351746009039	active site
351746009040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746009041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746009042	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
351746009043	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
351746009044	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
351746009045	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
351746009046	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
351746009047	Uncharacterized conserved protein [Function unknown]; Region: COG0393
351746009048	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
351746009049	EamA-like transporter family; Region: EamA; pfam00892
351746009050	aldolase II superfamily protein; Provisional; Region: PRK07044
351746009051	intersubunit interface [polypeptide binding]; other site
351746009052	active site
351746009053	Zn2+ binding site [ion binding]; other site
351746009054	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351746009055	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
351746009056	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
351746009057	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
351746009058	putative active site [active]
351746009059	putative FMN binding site [chemical binding]; other site
351746009060	putative substrate binding site [chemical binding]; other site
351746009061	putative catalytic residue [active]
351746009062	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
351746009063	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746009064	non-specific DNA binding site [nucleotide binding]; other site
351746009065	salt bridge; other site
351746009066	sequence-specific DNA binding site [nucleotide binding]; other site
351746009067	Cupin domain; Region: Cupin_2; pfam07883
351746009068	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
351746009069	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746009070	azoreductase; Reviewed; Region: PRK00170
351746009071	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746009072	LysR family transcriptional regulator; Provisional; Region: PRK14997
351746009073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746009075	dimerization interface [polypeptide binding]; other site
351746009076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
351746009077	Predicted membrane protein [Function unknown]; Region: COG3326
351746009078	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
351746009079	Cache domain; Region: Cache_2; pfam08269
351746009080	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746009081	dimerization interface [polypeptide binding]; other site
351746009082	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746009083	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746009084	dimer interface [polypeptide binding]; other site
351746009085	putative CheW interface [polypeptide binding]; other site
351746009086	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
351746009087	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
351746009088	AAA domain; Region: AAA_28; pfam13521
351746009089	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
351746009090	putative active site [active]
351746009091	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
351746009092	Sulfatase; Region: Sulfatase; pfam00884
351746009093	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
351746009094	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
351746009095	active site
351746009096	catalytic site [active]
351746009097	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
351746009098	G1 box; other site
351746009099	GTP/Mg2+ binding site [chemical binding]; other site
351746009100	Switch I region; other site
351746009101	Switch II region; other site
351746009102	G4 box; other site
351746009103	G5 box; other site
351746009104	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
351746009105	UreF; Region: UreF; pfam01730
351746009106	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
351746009107	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
351746009108	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
351746009109	dimer interface [polypeptide binding]; other site
351746009110	catalytic residues [active]
351746009111	urease subunit alpha; Reviewed; Region: ureC; PRK13207
351746009112	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
351746009113	subunit interactions [polypeptide binding]; other site
351746009114	active site
351746009115	flap region; other site
351746009116	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
351746009117	gamma-beta subunit interface [polypeptide binding]; other site
351746009118	alpha-beta subunit interface [polypeptide binding]; other site
351746009119	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
351746009120	alpha-gamma subunit interface [polypeptide binding]; other site
351746009121	beta-gamma subunit interface [polypeptide binding]; other site
351746009122	UreD urease accessory protein; Region: UreD; cl00530
351746009123	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
351746009124	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351746009125	active site
351746009126	DNA binding site [nucleotide binding]
351746009127	Int/Topo IB signature motif; other site
351746009128	NnrS protein; Region: NnrS; pfam05940
351746009129	DEAD-like helicases superfamily; Region: DEXDc2; smart00488
351746009130	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
351746009131	DEAD_2; Region: DEAD_2; pfam06733
351746009132	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
351746009133	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
351746009134	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
351746009135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746009136	D-galactonate transporter; Region: 2A0114; TIGR00893
351746009137	putative substrate translocation pore; other site
351746009138	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
351746009139	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
351746009140	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
351746009141	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
351746009142	galactarate dehydratase; Region: galactar-dH20; TIGR03248
351746009143	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
351746009144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009146	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
351746009147	putative dimerization interface [polypeptide binding]; other site
351746009148	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009150	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
351746009151	putative dimerization interface [polypeptide binding]; other site
351746009152	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
351746009153	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
351746009154	putative active site pocket [active]
351746009155	metal binding site [ion binding]; metal-binding site
351746009156	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
351746009157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746009158	putative substrate translocation pore; other site
351746009159	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746009160	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746009161	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
351746009162	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
351746009163	putative NAD(P) binding site [chemical binding]; other site
351746009164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009166	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
351746009167	putative substrate binding pocket [chemical binding]; other site
351746009168	putative dimerization interface [polypeptide binding]; other site
351746009169	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
351746009170	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
351746009171	active site
351746009172	Int/Topo IB signature motif; other site
351746009173	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351746009174	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351746009175	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746009176	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
351746009177	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746009178	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746009179	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
351746009180	Protein export membrane protein; Region: SecD_SecF; cl14618
351746009181	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
351746009182	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
351746009183	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
351746009184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746009185	active site
351746009186	phosphorylation site [posttranslational modification]
351746009187	intermolecular recognition site; other site
351746009188	dimerization interface [polypeptide binding]; other site
351746009189	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746009190	DNA binding residues [nucleotide binding]
351746009191	dimerization interface [polypeptide binding]; other site
351746009192	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746009193	PAS domain; Region: PAS_9; pfam13426
351746009194	putative active site [active]
351746009195	heme pocket [chemical binding]; other site
351746009196	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746009197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746009198	dimer interface [polypeptide binding]; other site
351746009199	phosphorylation site [posttranslational modification]
351746009200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746009201	ATP binding site [chemical binding]; other site
351746009202	Mg2+ binding site [ion binding]; other site
351746009203	G-X-G motif; other site
351746009204	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746009205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746009206	active site
351746009207	phosphorylation site [posttranslational modification]
351746009208	intermolecular recognition site; other site
351746009209	dimerization interface [polypeptide binding]; other site
351746009210	PAS domain S-box; Region: sensory_box; TIGR00229
351746009211	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746009212	putative active site [active]
351746009213	heme pocket [chemical binding]; other site
351746009214	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746009215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746009216	dimer interface [polypeptide binding]; other site
351746009217	phosphorylation site [posttranslational modification]
351746009218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746009219	ATP binding site [chemical binding]; other site
351746009220	Mg2+ binding site [ion binding]; other site
351746009221	G-X-G motif; other site
351746009222	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
351746009223	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
351746009224	active site
351746009225	catalytic residues [active]
351746009226	metal binding site [ion binding]; metal-binding site
351746009227	DmpG-like communication domain; Region: DmpG_comm; pfam07836
351746009228	acetaldehyde dehydrogenase; Validated; Region: PRK08300
351746009229	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351746009230	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
351746009231	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
351746009232	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
351746009233	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
351746009234	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
351746009235	active site
351746009236	Fe binding site [ion binding]; other site
351746009237	cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Region: BphB_TodD; TIGR03325
351746009238	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
351746009239	NAD binding site [chemical binding]; other site
351746009240	active site
351746009241	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
351746009242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746009243	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
351746009244	[2Fe-2S] cluster binding site [ion binding]; other site
351746009245	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
351746009246	inter-subunit interface; other site
351746009247	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
351746009248	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
351746009249	iron-sulfur cluster [ion binding]; other site
351746009250	[2Fe-2S] cluster binding site [ion binding]; other site
351746009251	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
351746009252	beta subunit interface [polypeptide binding]; other site
351746009253	alpha subunit interface [polypeptide binding]; other site
351746009254	active site
351746009255	substrate binding site [chemical binding]; other site
351746009256	Fe binding site [ion binding]; other site
351746009257	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
351746009258	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
351746009259	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
351746009260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009261	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
351746009262	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746009263	substrate binding site [chemical binding]; other site
351746009264	oxyanion hole (OAH) forming residues; other site
351746009265	trimer interface [polypeptide binding]; other site
351746009266	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
351746009267	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
351746009268	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
351746009269	active site
351746009270	catalytic residues [active]
351746009271	metal binding site [ion binding]; metal-binding site
351746009272	DmpG-like communication domain; Region: DmpG_comm; pfam07836
351746009273	acetaldehyde dehydrogenase; Validated; Region: PRK08300
351746009274	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351746009275	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
351746009276	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
351746009277	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746009278	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746009279	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746009280	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746009281	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
351746009282	intersubunit interface [polypeptide binding]; other site
351746009283	active site
351746009284	Zn2+ binding site [ion binding]; other site
351746009285	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
351746009286	[2Fe-2S] cluster binding site [ion binding]; other site
351746009287	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
351746009288	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
351746009289	putative NAD(P) binding site [chemical binding]; other site
351746009290	active site
351746009291	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
351746009292	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
351746009293	active site
351746009294	metal binding site [ion binding]; metal-binding site
351746009295	C-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC); Region: PpCmtC_C; cd07258
351746009296	putative active site [active]
351746009297	putative metal binding site [ion binding]; other site
351746009298	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
351746009299	inter-subunit interface; other site
351746009300	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
351746009301	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
351746009302	[2Fe-2S] cluster binding site [ion binding]; other site
351746009303	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
351746009304	putative alpha subunit interface [polypeptide binding]; other site
351746009305	putative active site [active]
351746009306	putative substrate binding site [chemical binding]; other site
351746009307	Fe binding site [ion binding]; other site
351746009308	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
351746009309	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
351746009310	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746009311	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
351746009312	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746009313	acyl-activating enzyme (AAE) consensus motif; other site
351746009314	AMP binding site [chemical binding]; other site
351746009315	active site
351746009316	CoA binding site [chemical binding]; other site
351746009317	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
351746009318	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
351746009319	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746009320	catalytic loop [active]
351746009321	iron binding site [ion binding]; other site
351746009322	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213
351746009323	FAD binding pocket [chemical binding]; other site
351746009324	FAD binding motif [chemical binding]; other site
351746009325	phosphate binding motif [ion binding]; other site
351746009326	beta-alpha-beta structure motif; other site
351746009327	NAD binding pocket [chemical binding]; other site
351746009328	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
351746009329	Fatty acid desaturase; Region: FA_desaturase; pfam00487
351746009330	Di-iron ligands [ion binding]; other site
351746009331	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
351746009332	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
351746009333	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746009334	NAD(P) binding site [chemical binding]; other site
351746009335	catalytic residues [active]
351746009336	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
351746009337	classical (c) SDRs; Region: SDR_c; cd05233
351746009338	NAD(P) binding site [chemical binding]; other site
351746009339	active site
351746009340	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
351746009341	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
351746009342	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746009343	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
351746009344	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
351746009345	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746009346	P-loop; other site
351746009347	Magnesium ion binding site [ion binding]; other site
351746009348	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746009349	Magnesium ion binding site [ion binding]; other site
351746009350	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
351746009351	ParB-like nuclease domain; Region: ParBc; pfam02195
351746009352	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
351746009353	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
351746009354	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
351746009355	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
351746009356	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351746009357	dimer interface [polypeptide binding]; other site
351746009358	ssDNA binding site [nucleotide binding]; other site
351746009359	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351746009360	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746009361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746009362	non-specific DNA binding site [nucleotide binding]; other site
351746009363	salt bridge; other site
351746009364	sequence-specific DNA binding site [nucleotide binding]; other site
351746009365	DNA topoisomerase III; Provisional; Region: PRK07726
351746009366	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
351746009367	active site
351746009368	putative interdomain interaction site [polypeptide binding]; other site
351746009369	putative metal-binding site [ion binding]; other site
351746009370	putative nucleotide binding site [chemical binding]; other site
351746009371	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
351746009372	domain I; other site
351746009373	DNA binding groove [nucleotide binding]
351746009374	phosphate binding site [ion binding]; other site
351746009375	domain II; other site
351746009376	domain III; other site
351746009377	nucleotide binding site [chemical binding]; other site
351746009378	catalytic site [active]
351746009379	domain IV; other site
351746009380	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
351746009381	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
351746009382	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
351746009383	MPN+ (JAMM) motif; other site
351746009384	Zinc-binding site [ion binding]; other site
351746009385	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
351746009386	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
351746009387	integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765
351746009388	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
351746009389	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
351746009390	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
351746009391	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
351746009392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009394	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746009395	dimerization interface [polypeptide binding]; other site
351746009396	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
351746009397	nudix motif; other site
351746009398	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
351746009399	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
351746009400	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
351746009401	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
351746009402	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
351746009403	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
351746009404	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
351746009405	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
351746009406	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
351746009407	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
351746009408	Protein of unknown function (DUF327); Region: DUF327; cl00753
351746009409	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
351746009410	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
351746009411	active site
351746009412	DNA binding site [nucleotide binding]
351746009413	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
351746009414	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746009415	Catalytic site [active]
351746009416	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
351746009417	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
351746009418	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
351746009419	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
351746009420	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
351746009421	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
351746009422	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
351746009423	Putative helicase; Region: TraI_2; pfam07514
351746009424	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
351746009425	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
351746009426	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746009427	AAA domain; Region: AAA_23; pfam13476
351746009428	Walker A/P-loop; other site
351746009429	ATP binding site [chemical binding]; other site
351746009430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746009431	ABC transporter signature motif; other site
351746009432	Walker B; other site
351746009433	D-loop; other site
351746009434	H-loop/switch region; other site
351746009435	Restriction endonuclease; Region: Mrr_cat; pfam04471
351746009436	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
351746009437	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746009438	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
351746009439	Helix-Turn-Helix DNA binding domain of MerR2-like transcription regulators; Region: HTH_MerR2; cd04769
351746009440	DNA binding residues [nucleotide binding]
351746009441	putative dimer interface [polypeptide binding]; other site
351746009442	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
351746009443	anti-sigma E factor; Provisional; Region: rseB; PRK09455
351746009444	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
351746009445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746009446	NAD(P) binding site [chemical binding]; other site
351746009447	active site
351746009448	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
351746009449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746009450	NAD(P) binding site [chemical binding]; other site
351746009451	active site
351746009452	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746009453	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746009454	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746009455	catalytic residue [active]
351746009456	Predicted dehydrogenase [General function prediction only]; Region: COG5322
351746009457	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
351746009458	active site
351746009459	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
351746009460	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
351746009461	dimer interface [polypeptide binding]; other site
351746009462	active site
351746009463	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
351746009464	active site
351746009465	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
351746009466	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
351746009467	dimer interface [polypeptide binding]; other site
351746009468	active site
351746009469	acyl carrier protein; Provisional; Region: acpP; PRK00982
351746009470	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746009471	Walker A/P-loop; other site
351746009472	ATP binding site [chemical binding]; other site
351746009473	Q-loop/lid; other site
351746009474	ABC transporter signature motif; other site
351746009475	Walker B; other site
351746009476	D-loop; other site
351746009477	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
351746009478	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
351746009479	Flavin binding site [chemical binding]; other site
351746009480	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
351746009481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746009482	Walker A motif; other site
351746009483	ATP binding site [chemical binding]; other site
351746009484	Walker B motif; other site
351746009485	arginine finger; other site
351746009486	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
351746009487	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746009488	putative ligand binding site [chemical binding]; other site
351746009489	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
351746009490	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351746009491	TM-ABC transporter signature motif; other site
351746009492	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351746009493	TM-ABC transporter signature motif; other site
351746009494	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
351746009495	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351746009496	Walker A/P-loop; other site
351746009497	ATP binding site [chemical binding]; other site
351746009498	Q-loop/lid; other site
351746009499	ABC transporter signature motif; other site
351746009500	Walker B; other site
351746009501	D-loop; other site
351746009502	H-loop/switch region; other site
351746009503	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746009504	acyl-activating enzyme (AAE) consensus motif; other site
351746009505	CoA binding site [chemical binding]; other site
351746009506	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
351746009507	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
351746009508	active site
351746009509	dimer interface [polypeptide binding]; other site
351746009510	non-prolyl cis peptide bond; other site
351746009511	insertion regions; other site
351746009512	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746009513	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
351746009514	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
351746009515	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
351746009516	Flavin binding site [chemical binding]; other site
351746009517	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351746009518	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746009519	TM-ABC transporter signature motif; other site
351746009520	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351746009521	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746009522	TM-ABC transporter signature motif; other site
351746009523	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
351746009524	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351746009525	Walker A/P-loop; other site
351746009526	ATP binding site [chemical binding]; other site
351746009527	Q-loop/lid; other site
351746009528	ABC transporter signature motif; other site
351746009529	Walker B; other site
351746009530	D-loop; other site
351746009531	H-loop/switch region; other site
351746009532	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351746009533	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
351746009534	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
351746009535	putative ligand binding site [chemical binding]; other site
351746009536	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
351746009537	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
351746009538	putative ligand binding site [chemical binding]; other site
351746009539	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
351746009540	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746009541	active site
351746009542	outer membrane porin, OprD family; Region: OprD; pfam03573
351746009543	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
351746009544	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351746009545	Walker A/P-loop; other site
351746009546	ATP binding site [chemical binding]; other site
351746009547	Q-loop/lid; other site
351746009548	ABC transporter signature motif; other site
351746009549	Walker B; other site
351746009550	D-loop; other site
351746009551	H-loop/switch region; other site
351746009552	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
351746009553	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746009554	putative ligand binding site [chemical binding]; other site
351746009555	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
351746009556	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746009557	putative ligand binding site [chemical binding]; other site
351746009558	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
351746009559	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351746009560	TM-ABC transporter signature motif; other site
351746009561	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746009562	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351746009563	TM-ABC transporter signature motif; other site
351746009564	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
351746009565	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351746009566	Walker A/P-loop; other site
351746009567	ATP binding site [chemical binding]; other site
351746009568	Q-loop/lid; other site
351746009569	ABC transporter signature motif; other site
351746009570	Walker B; other site
351746009571	D-loop; other site
351746009572	H-loop/switch region; other site
351746009573	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746009574	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
351746009575	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
351746009576	active site
351746009577	non-prolyl cis peptide bond; other site
351746009578	universal stress protein UspE; Provisional; Region: PRK11175
351746009579	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746009580	Ligand Binding Site [chemical binding]; other site
351746009581	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746009582	Ligand Binding Site [chemical binding]; other site
351746009583	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
351746009584	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
351746009585	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746009586	active site
351746009587	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
351746009588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746009589	Coenzyme A binding pocket [chemical binding]; other site
351746009590	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
351746009591	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
351746009592	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746009593	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
351746009594	DNA binding residues [nucleotide binding]
351746009595	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
351746009596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746009597	PAS domain; Region: PAS_9; pfam13426
351746009598	putative active site [active]
351746009599	heme pocket [chemical binding]; other site
351746009600	SnoaL-like domain; Region: SnoaL_2; pfam12680
351746009601	short chain dehydrogenase; Provisional; Region: PRK06101
351746009602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746009603	NAD(P) binding site [chemical binding]; other site
351746009604	active site
351746009605	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
351746009606	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746009607	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
351746009608	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
351746009609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746009610	S-adenosylmethionine binding site [chemical binding]; other site
351746009611	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
351746009612	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
351746009613	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
351746009614	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
351746009615	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
351746009616	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
351746009617	C factor cell-cell signaling protein; Provisional; Region: PRK09009
351746009618	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
351746009619	NADP binding site [chemical binding]; other site
351746009620	homodimer interface [polypeptide binding]; other site
351746009621	active site
351746009622	Predicted membrane protein [Function unknown]; Region: COG2323
351746009623	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
351746009624	intracellular protease, PfpI family; Region: PfpI; TIGR01382
351746009625	proposed catalytic triad [active]
351746009626	conserved cys residue [active]
351746009627	short chain dehydrogenase; Provisional; Region: PRK06701
351746009628	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
351746009629	NAD binding site [chemical binding]; other site
351746009630	metal binding site [ion binding]; metal-binding site
351746009631	active site
351746009632	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
351746009633	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746009634	dimerization interface [polypeptide binding]; other site
351746009635	putative DNA binding site [nucleotide binding]; other site
351746009636	putative Zn2+ binding site [ion binding]; other site
351746009637	arsenical pump membrane protein; Provisional; Region: PRK15445
351746009638	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
351746009639	transmembrane helices; other site
351746009640	Low molecular weight phosphatase family; Region: LMWPc; cd00115
351746009641	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
351746009642	active site
351746009643	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
351746009644	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746009645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746009646	dimer interface [polypeptide binding]; other site
351746009647	phosphorylation site [posttranslational modification]
351746009648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746009649	ATP binding site [chemical binding]; other site
351746009650	Mg2+ binding site [ion binding]; other site
351746009651	G-X-G motif; other site
351746009652	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
351746009653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746009654	active site
351746009655	phosphorylation site [posttranslational modification]
351746009656	intermolecular recognition site; other site
351746009657	dimerization interface [polypeptide binding]; other site
351746009658	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746009659	DNA binding site [nucleotide binding]
351746009660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746009661	TPR motif; other site
351746009662	binding surface
351746009663	short chain dehydrogenase; Provisional; Region: PRK09072
351746009664	classical (c) SDRs; Region: SDR_c; cd05233
351746009665	NAD(P) binding site [chemical binding]; other site
351746009666	active site
351746009667	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
351746009668	heme binding pocket [chemical binding]; other site
351746009669	heme ligand [chemical binding]; other site
351746009670	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
351746009671	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
351746009672	acyl-activating enzyme (AAE) consensus motif; other site
351746009673	putative AMP binding site [chemical binding]; other site
351746009674	putative active site [active]
351746009675	putative CoA binding site [chemical binding]; other site
351746009676	Thermostable hemolysin; Region: T_hemolysin; pfam12261
351746009677	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
351746009678	putative catalytic site [active]
351746009679	putative phosphate binding site [ion binding]; other site
351746009680	active site
351746009681	metal binding site A [ion binding]; metal-binding site
351746009682	DNA binding site [nucleotide binding]
351746009683	putative AP binding site [nucleotide binding]; other site
351746009684	putative metal binding site B [ion binding]; other site
351746009685	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
351746009686	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
351746009687	metal binding site [ion binding]; metal-binding site
351746009688	putative dimer interface [polypeptide binding]; other site
351746009689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746009690	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746009691	putative substrate translocation pore; other site
351746009692	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
351746009693	trimer interface [polypeptide binding]; other site
351746009694	eyelet of channel; other site
351746009695	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
351746009696	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009698	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746009699	dimerization interface [polypeptide binding]; other site
351746009700	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
351746009701	catalytic triad [active]
351746009702	dimer interface [polypeptide binding]; other site
351746009703	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
351746009704	methionine synthase; Provisional; Region: PRK01207
351746009705	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
351746009706	substrate binding site [chemical binding]; other site
351746009707	THF binding site; other site
351746009708	zinc-binding site [ion binding]; other site
351746009709	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
351746009710	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
351746009711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009712	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
351746009713	putative dimerization interface [polypeptide binding]; other site
351746009714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009716	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
351746009717	putative dimerization interface [polypeptide binding]; other site
351746009718	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
351746009719	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746009720	NAD(P) binding site [chemical binding]; other site
351746009721	catalytic residues [active]
351746009722	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
351746009723	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
351746009724	active site
351746009725	BCCT family transporter; Region: BCCT; pfam02028
351746009726	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
351746009727	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746009728	homotrimer interaction site [polypeptide binding]; other site
351746009729	putative active site [active]
351746009730	Uncharacterized conserved protein [Function unknown]; Region: COG2308
351746009731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
351746009732	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
351746009733	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
351746009734	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
351746009735	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
351746009736	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
351746009737	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
351746009738	GntP family permease; Region: GntP_permease; pfam02447
351746009739	fructuronate transporter; Provisional; Region: PRK10034; cl15264
351746009740	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
351746009741	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
351746009742	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746009743	catalytic residue [active]
351746009744	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
351746009745	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009746	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746009747	dimerization interface [polypeptide binding]; other site
351746009748	substrate binding pocket [chemical binding]; other site
351746009749	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746009750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746009751	DNA-binding site [nucleotide binding]; DNA binding site
351746009752	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746009753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746009754	homodimer interface [polypeptide binding]; other site
351746009755	catalytic residue [active]
351746009756	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
351746009757	homodimer interface [polypeptide binding]; other site
351746009758	catalytic residues [active]
351746009759	NAD binding site [chemical binding]; other site
351746009760	substrate binding pocket [chemical binding]; other site
351746009761	flexible flap; other site
351746009762	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
351746009763	active site
351746009764	catalytic residues [active]
351746009765	metal binding site [ion binding]; metal-binding site
351746009766	outer membrane porin, OprD family; Region: OprD; pfam03573
351746009767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
351746009768	PAS domain S-box; Region: sensory_box; TIGR00229
351746009769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746009770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746009771	dimer interface [polypeptide binding]; other site
351746009772	phosphorylation site [posttranslational modification]
351746009773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746009774	ATP binding site [chemical binding]; other site
351746009775	Mg2+ binding site [ion binding]; other site
351746009776	G-X-G motif; other site
351746009777	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746009778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746009779	active site
351746009780	phosphorylation site [posttranslational modification]
351746009781	intermolecular recognition site; other site
351746009782	dimerization interface [polypeptide binding]; other site
351746009783	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
351746009784	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351746009785	putative active site [active]
351746009786	metal binding site [ion binding]; metal-binding site
351746009787	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
351746009788	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
351746009789	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
351746009790	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746009791	NAD(P) binding site [chemical binding]; other site
351746009792	catalytic residues [active]
351746009793	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
351746009794	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
351746009795	dimer interface [polypeptide binding]; other site
351746009796	Trp docking motif [polypeptide binding]; other site
351746009797	active site
351746009798	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351746009799	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
351746009800	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
351746009801	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746009802	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746009803	substrate binding pocket [chemical binding]; other site
351746009804	membrane-bound complex binding site; other site
351746009805	hinge residues; other site
351746009806	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
351746009807	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
351746009808	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
351746009809	dimer interface [polypeptide binding]; other site
351746009810	Trp docking motif [polypeptide binding]; other site
351746009811	active site
351746009812	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
351746009813	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
351746009814	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
351746009815	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
351746009816	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
351746009817	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746009818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746009819	active site
351746009820	phosphorylation site [posttranslational modification]
351746009821	intermolecular recognition site; other site
351746009822	dimerization interface [polypeptide binding]; other site
351746009823	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746009824	DNA binding residues [nucleotide binding]
351746009825	dimerization interface [polypeptide binding]; other site
351746009826	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
351746009827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
351746009828	Histidine kinase; Region: HisKA_3; pfam07730
351746009829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746009830	ATP binding site [chemical binding]; other site
351746009831	Mg2+ binding site [ion binding]; other site
351746009832	G-X-G motif; other site
351746009833	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
351746009834	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
351746009835	ligand binding site [chemical binding]; other site
351746009836	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
351746009837	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746009838	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746009839	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
351746009840	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
351746009841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746009842	Walker A/P-loop; other site
351746009843	ATP binding site [chemical binding]; other site
351746009844	Q-loop/lid; other site
351746009845	ABC transporter signature motif; other site
351746009846	Walker B; other site
351746009847	D-loop; other site
351746009848	H-loop/switch region; other site
351746009849	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
351746009850	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
351746009851	Peptidase C26; Region: Peptidase_C26; pfam07722
351746009852	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
351746009853	catalytic triad [active]
351746009854	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
351746009855	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
351746009856	putative active site [active]
351746009857	catalytic residue [active]
351746009858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746009859	D-galactonate transporter; Region: 2A0114; TIGR00893
351746009860	putative substrate translocation pore; other site
351746009861	galactarate dehydratase; Region: galactar-dH20; TIGR03248
351746009862	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
351746009863	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
351746009864	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
351746009865	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
351746009866	dimer interface [polypeptide binding]; other site
351746009867	NADP binding site [chemical binding]; other site
351746009868	catalytic residues [active]
351746009869	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746009870	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746009871	DNA-binding site [nucleotide binding]; DNA binding site
351746009872	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746009873	Protein of unknown function (DUF998); Region: DUF998; pfam06197
351746009874	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009875	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009876	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
351746009877	putative substrate binding pocket [chemical binding]; other site
351746009878	putative dimerization interface [polypeptide binding]; other site
351746009879	Protein of unknown function, DUF606; Region: DUF606; pfam04657
351746009880	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
351746009881	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
351746009882	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746009883	N-terminal plug; other site
351746009884	ligand-binding site [chemical binding]; other site
351746009885	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
351746009886	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
351746009887	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
351746009888	PAAR motif; Region: PAAR_motif; pfam05488
351746009889	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
351746009890	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351746009891	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746009892	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
351746009893	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
351746009894	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
351746009895	shikimate binding site; other site
351746009896	NAD(P) binding site [chemical binding]; other site
351746009897	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
351746009898	Predicted oxidoreductase [General function prediction only]; Region: COG3573
351746009899	NIPSNAP; Region: NIPSNAP; pfam07978
351746009900	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
351746009901	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746009902	Predicted oxidoreductase [General function prediction only]; Region: COG3573
351746009903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746009904	D-galactonate transporter; Region: 2A0114; TIGR00893
351746009905	putative substrate translocation pore; other site
351746009906	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
351746009907	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351746009908	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351746009909	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351746009910	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351746009911	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746009912	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
351746009913	Predicted oxidoreductase [General function prediction only]; Region: COG3573
351746009914	Cache domain; Region: Cache_1; pfam02743
351746009915	GAF domain; Region: GAF_2; pfam13185
351746009916	GAF domain; Region: GAF_3; pfam13492
351746009917	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351746009918	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
351746009919	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
351746009920	NAD(P) binding site [chemical binding]; other site
351746009921	catalytic residues [active]
351746009922	putative aminotransferase; Provisional; Region: PRK12403
351746009923	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746009924	inhibitor-cofactor binding pocket; inhibition site
351746009925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746009926	catalytic residue [active]
351746009927	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746009928	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746009929	DNA binding residues [nucleotide binding]
351746009930	dimerization interface [polypeptide binding]; other site
351746009931	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
351746009932	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
351746009933	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
351746009934	dimer interface [polypeptide binding]; other site
351746009935	NADP binding site [chemical binding]; other site
351746009936	catalytic residues [active]
351746009937	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
351746009938	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
351746009939	active site
351746009940	putative substrate binding pocket [chemical binding]; other site
351746009941	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351746009942	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746009943	Coenzyme A binding pocket [chemical binding]; other site
351746009944	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
351746009945	heme binding pocket [chemical binding]; other site
351746009946	heme ligand [chemical binding]; other site
351746009947	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
351746009948	hypothetical protein; Provisional; Region: PRK10649
351746009949	Sulfatase; Region: Sulfatase; pfam00884
351746009950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
351746009951	Protein of unknown function (DUF330); Region: DUF330; pfam03886
351746009952	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
351746009953	mce related protein; Region: MCE; pfam02470
351746009954	mce related protein; Region: MCE; pfam02470
351746009955	mce related protein; Region: MCE; pfam02470
351746009956	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
351746009957	Paraquat-inducible protein A; Region: PqiA; pfam04403
351746009958	Paraquat-inducible protein A; Region: PqiA; pfam04403
351746009959	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746009960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746009961	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
351746009962	putative substrate binding pocket [chemical binding]; other site
351746009963	dimerization interface [polypeptide binding]; other site
351746009964	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746009965	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
351746009966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746009967	putative substrate translocation pore; other site
351746009968	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
351746009969	dimer interface [polypeptide binding]; other site
351746009970	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746009971	metal binding site [ion binding]; metal-binding site
351746009972	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746009973	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746009974	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
351746009975	Leucine-rich repeats; other site
351746009976	Substrate binding site [chemical binding]; other site
351746009977	Leucine rich repeat; Region: LRR_8; pfam13855
351746009978	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
351746009979	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
351746009980	Family description; Region: UvrD_C_2; pfam13538
351746009981	Pirin-related protein [General function prediction only]; Region: COG1741
351746009982	Pirin; Region: Pirin; pfam02678
351746009983	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
351746009984	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
351746009985	acyl-activating enzyme (AAE) consensus motif; other site
351746009986	AMP binding site [chemical binding]; other site
351746009987	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
351746009988	Acyltransferase family; Region: Acyl_transf_3; pfam01757
351746009989	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
351746009990	Isochorismatase family; Region: Isochorismatase; pfam00857
351746009991	catalytic triad [active]
351746009992	conserved cis-peptide bond; other site
351746009993	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
351746009994	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
351746009995	putative heme binding site [chemical binding]; other site
351746009996	putative substrate binding site [chemical binding]; other site
351746009997	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
351746009998	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
351746009999	putative heme binding site [chemical binding]; other site
351746010000	putative substrate binding site [chemical binding]; other site
351746010001	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
351746010002	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746010003	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
351746010004	Walker A/P-loop; other site
351746010005	ATP binding site [chemical binding]; other site
351746010006	Q-loop/lid; other site
351746010007	ABC transporter signature motif; other site
351746010008	Walker B; other site
351746010009	D-loop; other site
351746010010	H-loop/switch region; other site
351746010011	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
351746010012	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
351746010013	lipoyl-biotinyl attachment site [posttranslational modification]; other site
351746010014	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746010015	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
351746010016	PAS domain S-box; Region: sensory_box; TIGR00229
351746010017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746010018	putative active site [active]
351746010019	heme pocket [chemical binding]; other site
351746010020	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746010021	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746010022	metal binding site [ion binding]; metal-binding site
351746010023	active site
351746010024	I-site; other site
351746010025	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
351746010026	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
351746010027	Chromate transporter; Region: Chromate_transp; pfam02417
351746010028	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351746010029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746010030	S-adenosylmethionine binding site [chemical binding]; other site
351746010031	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
351746010032	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
351746010033	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
351746010034	dimer interface [polypeptide binding]; other site
351746010035	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
351746010036	active site
351746010037	Fe binding site [ion binding]; other site
351746010038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010039	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746010040	putative substrate translocation pore; other site
351746010041	tyrosine decarboxylase; Region: PLN02880
351746010042	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746010043	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746010044	catalytic residue [active]
351746010045	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010047	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
351746010048	substrate binding pocket [chemical binding]; other site
351746010049	dimerization interface [polypeptide binding]; other site
351746010050	hypothetical protein; Provisional; Region: PRK12378
351746010051	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746010052	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746010053	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
351746010054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010055	putative substrate translocation pore; other site
351746010056	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
351746010057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010058	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746010059	dimerization interface [polypeptide binding]; other site
351746010060	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
351746010061	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
351746010062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746010063	S-adenosylmethionine binding site [chemical binding]; other site
351746010064	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
351746010065	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746010066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746010067	DNA-binding site [nucleotide binding]; DNA binding site
351746010068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746010069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746010070	homodimer interface [polypeptide binding]; other site
351746010071	catalytic residue [active]
351746010072	WYL domain; Region: WYL; pfam13280
351746010073	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
351746010074	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
351746010075	putative NAD(P) binding site [chemical binding]; other site
351746010076	putative active site [active]
351746010077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010078	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
351746010079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746010080	dimerization interface [polypeptide binding]; other site
351746010081	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746010082	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746010083	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
351746010084	putative C-terminal domain interface [polypeptide binding]; other site
351746010085	putative GSH binding site (G-site) [chemical binding]; other site
351746010086	putative dimer interface [polypeptide binding]; other site
351746010087	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
351746010088	putative N-terminal domain interface [polypeptide binding]; other site
351746010089	putative dimer interface [polypeptide binding]; other site
351746010090	putative substrate binding pocket (H-site) [chemical binding]; other site
351746010091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010092	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746010093	putative substrate translocation pore; other site
351746010094	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010095	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
351746010096	putative effector binding pocket; other site
351746010097	putative dimerization interface [polypeptide binding]; other site
351746010098	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746010099	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746010100	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
351746010101	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
351746010102	active site
351746010103	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
351746010104	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
351746010105	dimerization interface [polypeptide binding]; other site
351746010106	NAD binding site [chemical binding]; other site
351746010107	ligand binding site [chemical binding]; other site
351746010108	catalytic site [active]
351746010109	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
351746010110	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
351746010111	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351746010112	homodimer interface [polypeptide binding]; other site
351746010113	substrate-cofactor binding pocket; other site
351746010114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746010115	catalytic residue [active]
351746010116	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
351746010117	Predicted ATPase [General function prediction only]; Region: COG4637
351746010118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746010119	Walker A/P-loop; other site
351746010120	ATP binding site [chemical binding]; other site
351746010121	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
351746010122	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351746010123	Zn2+ binding site [ion binding]; other site
351746010124	Mg2+ binding site [ion binding]; other site
351746010125	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746010126	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
351746010127	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746010128	N-terminal plug; other site
351746010129	ligand-binding site [chemical binding]; other site
351746010130	glutaminase; Provisional; Region: PRK00971
351746010131	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
351746010132	benzoate transport; Region: 2A0115; TIGR00895
351746010133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010134	putative substrate translocation pore; other site
351746010135	protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367
351746010136	The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950
351746010137	putative active site [active]
351746010138	Fe(II) binding site [ion binding]; other site
351746010139	putative dimer interface [polypeptide binding]; other site
351746010140	The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923
351746010141	putative dimer interface [polypeptide binding]; other site
351746010142	putative N- and C-terminal domain interface [polypeptide binding]; other site
351746010143	outer membrane porin, OprD family; Region: OprD; pfam03573
351746010144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010146	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
351746010147	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010148	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
351746010149	putative dimerization interface [polypeptide binding]; other site
351746010150	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
351746010151	hypothetical protein; Provisional; Region: PRK09262
351746010152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
351746010153	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
351746010154	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
351746010155	homodecamer interface [polypeptide binding]; other site
351746010156	GTP cyclohydrolase I; Provisional; Region: PLN03044
351746010157	active site
351746010158	putative catalytic site residues [active]
351746010159	zinc binding site [ion binding]; other site
351746010160	GTP-CH-I/GFRP interaction surface; other site
351746010161	Protein of unknown function, DUF393; Region: DUF393; pfam04134
351746010162	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746010163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746010164	Coenzyme A binding pocket [chemical binding]; other site
351746010165	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
351746010166	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
351746010167	active site
351746010168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746010169	NAD(P) binding site [chemical binding]; other site
351746010170	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
351746010171	active site
351746010172	Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290
351746010173	GAF domain; Region: GAF; pfam01590
351746010174	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
351746010175	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746010176	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746010177	metal binding site [ion binding]; metal-binding site
351746010178	active site
351746010179	I-site; other site
351746010180	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
351746010181	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
351746010182	DNA binding residues [nucleotide binding]
351746010183	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351746010184	IHF dimer interface [polypeptide binding]; other site
351746010185	IHF - DNA interface [nucleotide binding]; other site
351746010186	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
351746010187	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
351746010188	putative tRNA-binding site [nucleotide binding]; other site
351746010189	B3/4 domain; Region: B3_4; pfam03483
351746010190	tRNA synthetase B5 domain; Region: B5; smart00874
351746010191	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
351746010192	dimer interface [polypeptide binding]; other site
351746010193	motif 1; other site
351746010194	motif 3; other site
351746010195	motif 2; other site
351746010196	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
351746010197	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
351746010198	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
351746010199	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
351746010200	dimer interface [polypeptide binding]; other site
351746010201	motif 1; other site
351746010202	active site
351746010203	motif 2; other site
351746010204	motif 3; other site
351746010205	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
351746010206	23S rRNA binding site [nucleotide binding]; other site
351746010207	L21 binding site [polypeptide binding]; other site
351746010208	L13 binding site [polypeptide binding]; other site
351746010209	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
351746010210	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
351746010211	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
351746010212	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
351746010213	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
351746010214	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
351746010215	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
351746010216	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
351746010217	active site
351746010218	dimer interface [polypeptide binding]; other site
351746010219	motif 1; other site
351746010220	motif 2; other site
351746010221	motif 3; other site
351746010222	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
351746010223	anticodon binding site; other site
351746010224	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351746010225	DNA-binding site [nucleotide binding]; DNA binding site
351746010226	RNA-binding motif; other site
351746010227	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
351746010228	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
351746010229	active site
351746010230	tetramer interface [polypeptide binding]; other site
351746010231	D-ribose pyranase; Provisional; Region: PRK11797
351746010232	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
351746010233	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
351746010234	substrate binding site [chemical binding]; other site
351746010235	dimer interface [polypeptide binding]; other site
351746010236	ATP binding site [chemical binding]; other site
351746010237	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351746010238	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351746010239	DNA binding site [nucleotide binding]
351746010240	domain linker motif; other site
351746010241	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
351746010242	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746010243	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351746010244	TM-ABC transporter signature motif; other site
351746010245	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
351746010246	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351746010247	Walker A/P-loop; other site
351746010248	ATP binding site [chemical binding]; other site
351746010249	Q-loop/lid; other site
351746010250	ABC transporter signature motif; other site
351746010251	Walker B; other site
351746010252	D-loop; other site
351746010253	H-loop/switch region; other site
351746010254	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351746010255	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
351746010256	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
351746010257	ligand binding site [chemical binding]; other site
351746010258	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
351746010259	homodimer interface [polypeptide binding]; other site
351746010260	active site
351746010261	PAS domain S-box; Region: sensory_box; TIGR00229
351746010262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746010263	putative active site [active]
351746010264	heme pocket [chemical binding]; other site
351746010265	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
351746010266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746010267	Walker A motif; other site
351746010268	ATP binding site [chemical binding]; other site
351746010269	Walker B motif; other site
351746010270	arginine finger; other site
351746010271	cyanate hydratase; Validated; Region: PRK02866
351746010272	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
351746010273	oligomer interface [polypeptide binding]; other site
351746010274	active site
351746010275	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
351746010276	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
351746010277	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
351746010278	DNA-specific endonuclease I; Provisional; Region: PRK15137
351746010279	HD domain; Region: HD_4; pfam13328
351746010280	Sporulation related domain; Region: SPOR; pfam05036
351746010281	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746010282	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746010283	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
351746010284	putative active site [active]
351746010285	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
351746010286	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
351746010287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010288	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
351746010289	putative dimerization interface [polypeptide binding]; other site
351746010290	serine/threonine transporter SstT; Provisional; Region: PRK13628
351746010291	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746010292	Protein of unknown function, DUF480; Region: DUF480; pfam04337
351746010293	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
351746010294	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
351746010295	catalytic residue [active]
351746010296	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
351746010297	catalytic residues [active]
351746010298	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746010299	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746010300	peroxiredoxin; Region: AhpC; TIGR03137
351746010301	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
351746010302	dimer interface [polypeptide binding]; other site
351746010303	decamer (pentamer of dimers) interface [polypeptide binding]; other site
351746010304	catalytic triad [active]
351746010305	peroxidatic and resolving cysteines [active]
351746010306	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
351746010307	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746010308	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
351746010309	FAD binding site [chemical binding]; other site
351746010310	substrate binding site [chemical binding]; other site
351746010311	catalytic base [active]
351746010312	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
351746010313	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010314	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
351746010315	substrate binding pocket [chemical binding]; other site
351746010316	dimerization interface [polypeptide binding]; other site
351746010317	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746010318	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
351746010319	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746010320	catalytic residue [active]
351746010321	RES domain; Region: RES; pfam08808
351746010322	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
351746010323	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
351746010324	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
351746010325	FMN binding site [chemical binding]; other site
351746010326	dimer interface [polypeptide binding]; other site
351746010327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010329	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746010330	putative effector binding pocket; other site
351746010331	dimerization interface [polypeptide binding]; other site
351746010332	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746010333	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746010334	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010336	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746010337	putative arabinose transporter; Provisional; Region: PRK03545
351746010338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010339	putative substrate translocation pore; other site
351746010340	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
351746010341	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
351746010342	putative NAD(P) binding site [chemical binding]; other site
351746010343	putative substrate binding site [chemical binding]; other site
351746010344	catalytic Zn binding site [ion binding]; other site
351746010345	structural Zn binding site [ion binding]; other site
351746010346	dimer interface [polypeptide binding]; other site
351746010347	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
351746010348	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746010349	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010351	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
351746010352	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
351746010353	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
351746010354	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
351746010355	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
351746010356	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
351746010357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746010358	Coenzyme A binding pocket [chemical binding]; other site
351746010359	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746010360	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746010361	N-terminal plug; other site
351746010362	ligand-binding site [chemical binding]; other site
351746010363	Predicted membrane protein [Function unknown]; Region: COG3503
351746010364	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
351746010365	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
351746010366	putative ligand binding residues [chemical binding]; other site
351746010367	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351746010368	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
351746010369	dimer interface [polypeptide binding]; other site
351746010370	putative PBP binding regions; other site
351746010371	ABC-ATPase subunit  interface; other site
351746010372	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
351746010373	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
351746010374	Walker A/P-loop; other site
351746010375	ATP binding site [chemical binding]; other site
351746010376	Q-loop/lid; other site
351746010377	ABC transporter signature motif; other site
351746010378	Walker B; other site
351746010379	D-loop; other site
351746010380	H-loop/switch region; other site
351746010381	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
351746010382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746010383	Coenzyme A binding pocket [chemical binding]; other site
351746010384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746010385	Cache domain; Region: Cache_1; pfam02743
351746010386	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746010387	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746010388	metal binding site [ion binding]; metal-binding site
351746010389	active site
351746010390	I-site; other site
351746010391	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
351746010392	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746010393	P-loop; other site
351746010394	Magnesium ion binding site [ion binding]; other site
351746010395	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746010396	Magnesium ion binding site [ion binding]; other site
351746010397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010398	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746010399	putative substrate translocation pore; other site
351746010400	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
351746010401	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
351746010402	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746010403	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
351746010404	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
351746010405	Dehydroquinase class II; Region: DHquinase_II; pfam01220
351746010406	trimer interface [polypeptide binding]; other site
351746010407	active site
351746010408	dimer interface [polypeptide binding]; other site
351746010409	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
351746010410	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
351746010411	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
351746010412	shikimate binding site; other site
351746010413	NAD(P) binding site [chemical binding]; other site
351746010414	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
351746010415	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746010416	catalytic residues [active]
351746010417	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
351746010418	osmolarity response regulator; Provisional; Region: ompR; PRK09468
351746010419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746010420	active site
351746010421	phosphorylation site [posttranslational modification]
351746010422	intermolecular recognition site; other site
351746010423	dimerization interface [polypeptide binding]; other site
351746010424	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746010425	DNA binding site [nucleotide binding]
351746010426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
351746010427	dimer interface [polypeptide binding]; other site
351746010428	phosphorylation site [posttranslational modification]
351746010429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746010430	ATP binding site [chemical binding]; other site
351746010431	Mg2+ binding site [ion binding]; other site
351746010432	G-X-G motif; other site
351746010433	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
351746010434	Predicted membrane protein [Function unknown]; Region: COG2259
351746010435	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
351746010436	hypothetical protein; Provisional; Region: PRK05409
351746010437	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
351746010438	EF-hand domain pair; Region: EF_hand_5; pfam13499
351746010439	Ca2+ binding site [ion binding]; other site
351746010440	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
351746010441	Leucine rich repeat; Region: LRR_8; pfam13855
351746010442	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
351746010443	Leucine-rich repeats; other site
351746010444	Substrate binding site [chemical binding]; other site
351746010445	Leucine rich repeat; Region: LRR_8; pfam13855
351746010446	DNA polymerase II; Reviewed; Region: PRK05762
351746010447	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
351746010448	active site
351746010449	catalytic site [active]
351746010450	substrate binding site [chemical binding]; other site
351746010451	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
351746010452	active site
351746010453	metal-binding site
351746010454	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
351746010455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010456	putative substrate translocation pore; other site
351746010457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010459	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
351746010460	putative effector binding pocket; other site
351746010461	putative dimerization interface [polypeptide binding]; other site
351746010462	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746010463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746010465	dimerization interface [polypeptide binding]; other site
351746010466	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
351746010467	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746010468	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
351746010469	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
351746010470	Predicted membrane protein [Function unknown]; Region: COG4392
351746010471	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746010472	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746010473	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010474	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010475	H+ Antiporter protein; Region: 2A0121; TIGR00900
351746010476	Protein of unknown function (DUF461); Region: DUF461; pfam04314
351746010477	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
351746010478	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
351746010479	Cu(I) binding site [ion binding]; other site
351746010480	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
351746010481	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
351746010482	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
351746010483	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
351746010484	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
351746010485	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
351746010486	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
351746010487	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
351746010488	substrate binding pocket [chemical binding]; other site
351746010489	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
351746010490	B12 binding site [chemical binding]; other site
351746010491	cobalt ligand [ion binding]; other site
351746010492	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
351746010493	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
351746010494	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
351746010495	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
351746010496	putative ligand binding site [chemical binding]; other site
351746010497	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
351746010498	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
351746010499	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
351746010500	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
351746010501	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
351746010502	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746010503	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746010504	active site
351746010505	catalytic tetrad [active]
351746010506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010507	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746010508	putative substrate translocation pore; other site
351746010509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010510	putative substrate translocation pore; other site
351746010511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746010512	Cupin domain; Region: Cupin_2; cl17218
351746010513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010514	Helix-turn-helix domain; Region: HTH_18; pfam12833
351746010515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010516	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
351746010517	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
351746010518	active site
351746010519	Zn binding site [ion binding]; other site
351746010520	Spore Coat Protein U domain; Region: SCPU; pfam05229
351746010521	Spore Coat Protein U domain; Region: SCPU; pfam05229
351746010522	PapC N-terminal domain; Region: PapC_N; pfam13954
351746010523	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
351746010524	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
351746010525	PapC C-terminal domain; Region: PapC_C; pfam13953
351746010526	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
351746010527	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
351746010528	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
351746010529	Spore Coat Protein U domain; Region: SCPU; pfam05229
351746010530	Spore Coat Protein U domain; Region: SCPU; pfam05229
351746010531	Spore Coat Protein U domain; Region: SCPU; pfam05229
351746010532	Spore Coat Protein U domain; Region: SCPU; pfam05229
351746010533	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
351746010534	GAF domain; Region: GAF; pfam01590
351746010535	Phytochrome region; Region: PHY; pfam00360
351746010536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746010537	dimer interface [polypeptide binding]; other site
351746010538	phosphorylation site [posttranslational modification]
351746010539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746010540	ATP binding site [chemical binding]; other site
351746010541	Mg2+ binding site [ion binding]; other site
351746010542	G-X-G motif; other site
351746010543	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746010544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746010545	active site
351746010546	phosphorylation site [posttranslational modification]
351746010547	intermolecular recognition site; other site
351746010548	dimerization interface [polypeptide binding]; other site
351746010549	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746010550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746010551	active site
351746010552	phosphorylation site [posttranslational modification]
351746010553	intermolecular recognition site; other site
351746010554	dimerization interface [polypeptide binding]; other site
351746010555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746010556	PAS fold; Region: PAS_3; pfam08447
351746010557	putative active site [active]
351746010558	heme pocket [chemical binding]; other site
351746010559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746010560	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
351746010561	putative active site [active]
351746010562	heme pocket [chemical binding]; other site
351746010563	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746010564	dimer interface [polypeptide binding]; other site
351746010565	phosphorylation site [posttranslational modification]
351746010566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746010567	ATP binding site [chemical binding]; other site
351746010568	Mg2+ binding site [ion binding]; other site
351746010569	G-X-G motif; other site
351746010570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746010571	Response regulator receiver domain; Region: Response_reg; pfam00072
351746010572	intermolecular recognition site; other site
351746010573	active site
351746010574	dimerization interface [polypeptide binding]; other site
351746010575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
351746010576	Predicted ATPase [General function prediction only]; Region: COG1485
351746010577	Walker A motif; other site
351746010578	ATP binding site [chemical binding]; other site
351746010579	Walker B motif; other site
351746010580	arginine finger; other site
351746010581	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
351746010582	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
351746010583	acyl-activating enzyme (AAE) consensus motif; other site
351746010584	putative AMP binding site [chemical binding]; other site
351746010585	putative active site [active]
351746010586	putative CoA binding site [chemical binding]; other site
351746010587	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010589	LysR substrate binding domain; Region: LysR_substrate; pfam03466
351746010590	dimerization interface [polypeptide binding]; other site
351746010591	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
351746010592	HPP family; Region: HPP; pfam04982
351746010593	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
351746010594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
351746010595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746010596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746010597	ATP binding site [chemical binding]; other site
351746010598	Mg2+ binding site [ion binding]; other site
351746010599	G-X-G motif; other site
351746010600	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746010601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746010602	active site
351746010603	phosphorylation site [posttranslational modification]
351746010604	intermolecular recognition site; other site
351746010605	dimerization interface [polypeptide binding]; other site
351746010606	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746010607	DNA binding site [nucleotide binding]
351746010608	Predicted membrane protein [Function unknown]; Region: COG3212
351746010609	Predicted membrane protein [Function unknown]; Region: COG3212
351746010610	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
351746010611	integrase; Provisional; Region: PRK09692
351746010612	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
351746010613	active site
351746010614	Int/Topo IB signature motif; other site
351746010615	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
351746010616	virion protein; Provisional; Region: V; PHA02564
351746010617	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
351746010618	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
351746010619	Phage-related minor tail protein [Function unknown]; Region: COG5281
351746010620	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
351746010621	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
351746010622	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
351746010623	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
351746010624	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
351746010625	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
351746010626	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
351746010627	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
351746010628	Terminase-like family; Region: Terminase_6; pfam03237
351746010629	Phage terminase large subunit; Region: Terminase_3; cl12054
351746010630	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
351746010631	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
351746010632	active site
351746010633	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
351746010634	NinB protein; Region: NinB; pfam05772
351746010635	Replication protein P; Region: Phage_lambda_P; pfam06992
351746010636	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
351746010637	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
351746010638	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746010639	sequence-specific DNA binding site [nucleotide binding]; other site
351746010640	salt bridge; other site
351746010641	Predicted transcriptional regulator [Transcription]; Region: COG2932
351746010642	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746010643	Catalytic site [active]
351746010644	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
351746010645	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
351746010646	Protein of unknown function (DUF551); Region: DUF551; pfam04448
351746010647	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
351746010648	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351746010649	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
351746010650	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
351746010651	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
351746010652	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
351746010653	active site
351746010654	Predicted Fe-S protein [General function prediction only]; Region: COG3313
351746010655	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
351746010656	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
351746010657	substrate binding site [chemical binding]; other site
351746010658	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
351746010659	substrate binding site [chemical binding]; other site
351746010660	ligand binding site [chemical binding]; other site
351746010661	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
351746010662	2-methylcitrate dehydratase; Region: prpD; TIGR02330
351746010663	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
351746010664	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
351746010665	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
351746010666	substrate binding site [chemical binding]; other site
351746010667	ligand binding site [chemical binding]; other site
351746010668	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
351746010669	substrate binding site [chemical binding]; other site
351746010670	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
351746010671	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
351746010672	dimer interface [polypeptide binding]; other site
351746010673	active site
351746010674	citrylCoA binding site [chemical binding]; other site
351746010675	oxalacetate/citrate binding site [chemical binding]; other site
351746010676	coenzyme A binding site [chemical binding]; other site
351746010677	catalytic triad [active]
351746010678	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
351746010679	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
351746010680	tetramer interface [polypeptide binding]; other site
351746010681	active site
351746010682	Mg2+/Mn2+ binding site [ion binding]; other site
351746010683	Transcriptional regulators [Transcription]; Region: GntR; COG1802
351746010684	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746010685	DNA-binding site [nucleotide binding]; DNA binding site
351746010686	FCD domain; Region: FCD; pfam07729
351746010687	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
351746010688	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
351746010689	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
351746010690	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
351746010691	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
351746010692	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
351746010693	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
351746010694	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
351746010695	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
351746010696	Active Sites [active]
351746010697	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
351746010698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010699	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
351746010700	substrate binding site [chemical binding]; other site
351746010701	dimerization interface [polypeptide binding]; other site
351746010702	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746010703	Ligand Binding Site [chemical binding]; other site
351746010704	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
351746010705	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
351746010706	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
351746010707	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
351746010708	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
351746010709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746010710	Coenzyme A binding pocket [chemical binding]; other site
351746010711	L,D-transpeptidase; Provisional; Region: PRK10260
351746010712	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
351746010713	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
351746010714	active site
351746010715	catalytic triad [active]
351746010716	oxyanion hole [active]
351746010717	switch loop; other site
351746010718	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
351746010719	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351746010720	Walker A/P-loop; other site
351746010721	ATP binding site [chemical binding]; other site
351746010722	Q-loop/lid; other site
351746010723	ABC transporter signature motif; other site
351746010724	Walker B; other site
351746010725	D-loop; other site
351746010726	H-loop/switch region; other site
351746010727	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
351746010728	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
351746010729	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
351746010730	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
351746010731	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
351746010732	Predicted membrane protein [Function unknown]; Region: COG2259
351746010733	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746010734	substrate binding pocket [chemical binding]; other site
351746010735	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
351746010736	membrane-bound complex binding site; other site
351746010737	hinge residues; other site
351746010738	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746010739	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746010740	catalytic residue [active]
351746010741	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
351746010742	active site
351746010743	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746010744	dimerization interface [polypeptide binding]; other site
351746010745	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746010746	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746010747	dimer interface [polypeptide binding]; other site
351746010748	putative CheW interface [polypeptide binding]; other site
351746010749	Terminase small subunit; Region: Terminase_2; cl01513
351746010750	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
351746010751	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
351746010752	active site
351746010753	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
351746010754	active site 2 [active]
351746010755	active site 1 [active]
351746010756	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
351746010757	hypothetical protein; Provisional; Region: PRK10279
351746010758	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
351746010759	active site
351746010760	nucleophile elbow; other site
351746010761	periplasmic folding chaperone; Provisional; Region: PRK10788
351746010762	SurA N-terminal domain; Region: SurA_N_3; pfam13624
351746010763	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
351746010764	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351746010765	IHF dimer interface [polypeptide binding]; other site
351746010766	IHF - DNA interface [nucleotide binding]; other site
351746010767	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
351746010768	Found in ATP-dependent protease La (LON); Region: LON; smart00464
351746010769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746010770	Walker A motif; other site
351746010771	ATP binding site [chemical binding]; other site
351746010772	Walker B motif; other site
351746010773	arginine finger; other site
351746010774	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
351746010775	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
351746010776	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
351746010777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746010778	Walker A motif; other site
351746010779	ATP binding site [chemical binding]; other site
351746010780	Walker B motif; other site
351746010781	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
351746010782	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
351746010783	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
351746010784	oligomer interface [polypeptide binding]; other site
351746010785	active site residues [active]
351746010786	trigger factor; Provisional; Region: tig; PRK01490
351746010787	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746010788	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
351746010789	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
351746010790	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
351746010791	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
351746010792	homodimer interface [polypeptide binding]; other site
351746010793	NADP binding site [chemical binding]; other site
351746010794	substrate binding site [chemical binding]; other site
351746010795	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351746010796	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
351746010797	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351746010798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746010799	dimer interface [polypeptide binding]; other site
351746010800	conserved gate region; other site
351746010801	putative PBP binding loops; other site
351746010802	ABC-ATPase subunit interface; other site
351746010803	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351746010804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746010805	dimer interface [polypeptide binding]; other site
351746010806	conserved gate region; other site
351746010807	putative PBP binding loops; other site
351746010808	ABC-ATPase subunit interface; other site
351746010809	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
351746010810	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
351746010811	Walker A/P-loop; other site
351746010812	ATP binding site [chemical binding]; other site
351746010813	Q-loop/lid; other site
351746010814	ABC transporter signature motif; other site
351746010815	Walker B; other site
351746010816	D-loop; other site
351746010817	H-loop/switch region; other site
351746010818	TOBE domain; Region: TOBE_2; pfam08402
351746010819	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
351746010820	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
351746010821	Walker A/P-loop; other site
351746010822	ATP binding site [chemical binding]; other site
351746010823	Q-loop/lid; other site
351746010824	ABC transporter signature motif; other site
351746010825	Walker B; other site
351746010826	D-loop; other site
351746010827	H-loop/switch region; other site
351746010828	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
351746010829	GAF domain; Region: GAF; pfam01590
351746010830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746010831	Walker A motif; other site
351746010832	ATP binding site [chemical binding]; other site
351746010833	Walker B motif; other site
351746010834	arginine finger; other site
351746010835	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746010836	PAS domain; Region: PAS_9; pfam13426
351746010837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746010838	putative active site [active]
351746010839	heme pocket [chemical binding]; other site
351746010840	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746010841	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746010842	metal binding site [ion binding]; metal-binding site
351746010843	active site
351746010844	I-site; other site
351746010845	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746010846	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746010847	PAS fold; Region: PAS_3; pfam08447
351746010848	putative active site [active]
351746010849	heme pocket [chemical binding]; other site
351746010850	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746010851	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746010852	dimer interface [polypeptide binding]; other site
351746010853	putative CheW interface [polypeptide binding]; other site
351746010854	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746010855	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746010856	non-specific DNA binding site [nucleotide binding]; other site
351746010857	salt bridge; other site
351746010858	sequence-specific DNA binding site [nucleotide binding]; other site
351746010859	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
351746010860	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746010861	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746010862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746010863	DNA-binding site [nucleotide binding]; DNA binding site
351746010864	FCD domain; Region: FCD; pfam07729
351746010865	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746010866	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746010867	DNA-binding site [nucleotide binding]; DNA binding site
351746010868	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746010869	Predicted membrane protein [Function unknown]; Region: COG4125
351746010870	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
351746010871	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
351746010872	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746010873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010874	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746010875	dimerization interface [polypeptide binding]; other site
351746010876	Cache domain; Region: Cache_1; pfam02743
351746010877	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746010878	dimerization interface [polypeptide binding]; other site
351746010879	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746010880	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746010881	dimer interface [polypeptide binding]; other site
351746010882	putative CheW interface [polypeptide binding]; other site
351746010883	Uncharacterized membrane protein [Function unknown]; Region: COG3949
351746010884	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746010885	homotrimer interaction site [polypeptide binding]; other site
351746010886	putative active site [active]
351746010887	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746010888	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351746010889	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746010890	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746010891	non-specific DNA binding site [nucleotide binding]; other site
351746010892	salt bridge; other site
351746010893	sequence-specific DNA binding site [nucleotide binding]; other site
351746010894	Cupin domain; Region: Cupin_2; pfam07883
351746010895	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746010896	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
351746010897	outer membrane receptor FepA; Provisional; Region: PRK13524
351746010898	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746010899	N-terminal plug; other site
351746010900	ligand-binding site [chemical binding]; other site
351746010901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746010902	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746010903	putative substrate translocation pore; other site
351746010904	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
351746010905	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
351746010906	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
351746010907	threonine and homoserine efflux system; Provisional; Region: PRK10532
351746010908	EamA-like transporter family; Region: EamA; pfam00892
351746010909	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
351746010910	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
351746010911	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
351746010912	active site
351746010913	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
351746010914	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746010915	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746010916	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
351746010917	conserved cys residue [active]
351746010918	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010919	Isochorismatase family; Region: Isochorismatase; pfam00857
351746010920	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
351746010921	catalytic triad [active]
351746010922	conserved cis-peptide bond; other site
351746010923	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746010924	non-specific DNA binding site [nucleotide binding]; other site
351746010925	salt bridge; other site
351746010926	sequence-specific DNA binding site [nucleotide binding]; other site
351746010927	Cupin domain; Region: Cupin_2; pfam07883
351746010928	EamA-like transporter family; Region: EamA; pfam00892
351746010929	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
351746010930	EamA-like transporter family; Region: EamA; cl17759
351746010931	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
351746010932	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
351746010933	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
351746010934	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
351746010935	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
351746010936	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
351746010937	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
351746010938	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
351746010939	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
351746010940	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
351746010941	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
351746010942	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
351746010943	Helix-turn-helix domain; Region: HTH_28; pfam13518
351746010944	putative transposase OrfB; Reviewed; Region: PHA02517
351746010945	Homeodomain-like domain; Region: HTH_32; pfam13565
351746010946	Integrase core domain; Region: rve; pfam00665
351746010947	Integrase core domain; Region: rve_3; pfam13683
351746010948	enoyl-CoA hydratase; Provisional; Region: PRK05862
351746010949	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746010950	substrate binding site [chemical binding]; other site
351746010951	oxyanion hole (OAH) forming residues; other site
351746010952	trimer interface [polypeptide binding]; other site
351746010953	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746010954	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
351746010955	FAD binding site [chemical binding]; other site
351746010956	homotetramer interface [polypeptide binding]; other site
351746010957	substrate binding pocket [chemical binding]; other site
351746010958	catalytic base [active]
351746010959	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
351746010960	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746010961	dimer interface [polypeptide binding]; other site
351746010962	active site
351746010963	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
351746010964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746010965	NAD(P) binding site [chemical binding]; other site
351746010966	active site
351746010967	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
351746010968	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746010969	acyl-activating enzyme (AAE) consensus motif; other site
351746010970	AMP binding site [chemical binding]; other site
351746010971	active site
351746010972	CoA binding site [chemical binding]; other site
351746010973	Leucine rich repeat; Region: LRR_8; pfam13855
351746010974	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746010975	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746010976	SurA N-terminal domain; Region: SurA_N; pfam09312
351746010977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746010978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746010979	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
351746010980	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746010981	dimerization interface [polypeptide binding]; other site
351746010982	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
351746010983	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746010984	catalytic residue [active]
351746010985	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
351746010986	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746010987	motif II; other site
351746010988	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
351746010989	Domain of unknown function DUF20; Region: UPF0118; pfam01594
351746010990	putative protease; Provisional; Region: PRK15452
351746010991	Peptidase family U32; Region: Peptidase_U32; pfam01136
351746010992	Protein of unknown function, DUF; Region: DUF411; cl01142
351746010993	Predicted membrane protein [Function unknown]; Region: COG1238
351746010994	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
351746010995	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746010996	DinB family; Region: DinB; cl17821
351746010997	DinB superfamily; Region: DinB_2; pfam12867
351746010998	Predicted ATPase [General function prediction only]; Region: COG1485
351746010999	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
351746011000	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
351746011001	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
351746011002	agmatinase; Region: agmatinase; TIGR01230
351746011003	oligomer interface [polypeptide binding]; other site
351746011004	putative active site [active]
351746011005	Mn binding site [ion binding]; other site
351746011006	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746011007	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746011008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011010	LysR substrate binding domain; Region: LysR_substrate; pfam03466
351746011011	dimerization interface [polypeptide binding]; other site
351746011012	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746011013	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746011014	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746011015	N-terminal plug; other site
351746011016	ligand-binding site [chemical binding]; other site
351746011017	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746011018	RNA polymerase sigma factor; Reviewed; Region: PRK12527
351746011019	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746011020	DNA binding residues [nucleotide binding]
351746011021	FecR protein; Region: FecR; pfam04773
351746011022	Water Stress and Hypersensitive response; Region: WHy; smart00769
351746011023	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
351746011024	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
351746011025	active site
351746011026	dinuclear metal binding site [ion binding]; other site
351746011027	dimerization interface [polypeptide binding]; other site
351746011028	universal stress protein UspE; Provisional; Region: PRK11175
351746011029	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746011030	Ligand Binding Site [chemical binding]; other site
351746011031	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746011032	Ligand Binding Site [chemical binding]; other site
351746011033	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
351746011034	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
351746011035	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746011036	catalytic loop [active]
351746011037	iron binding site [ion binding]; other site
351746011038	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
351746011039	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351746011040	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
351746011041	[4Fe-4S] binding site [ion binding]; other site
351746011042	molybdopterin cofactor binding site; other site
351746011043	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
351746011044	molybdopterin cofactor binding site; other site
351746011045	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
351746011046	putative dimer interface [polypeptide binding]; other site
351746011047	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
351746011048	SLBB domain; Region: SLBB; pfam10531
351746011049	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
351746011050	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
351746011051	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
351746011052	putative dimer interface [polypeptide binding]; other site
351746011053	[2Fe-2S] cluster binding site [ion binding]; other site
351746011054	putative kissing complex interaction region; other site
351746011055	putative RNA binding sites [nucleotide binding]; other site
351746011056	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
351746011057	ProQ/FINO family; Region: ProQ; pfam04352
351746011058	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746011059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746011060	non-specific DNA binding site [nucleotide binding]; other site
351746011061	salt bridge; other site
351746011062	sequence-specific DNA binding site [nucleotide binding]; other site
351746011063	Cupin domain; Region: Cupin_2; pfam07883
351746011064	putative aminotransferase; Validated; Region: PRK07480
351746011065	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746011066	inhibitor-cofactor binding pocket; inhibition site
351746011067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746011068	catalytic residue [active]
351746011069	Peptidase C26; Region: Peptidase_C26; pfam07722
351746011070	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
351746011071	catalytic triad [active]
351746011072	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746011073	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746011074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746011075	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351746011076	non-specific DNA binding site [nucleotide binding]; other site
351746011077	salt bridge; other site
351746011078	sequence-specific DNA binding site [nucleotide binding]; other site
351746011079	Cupin domain; Region: Cupin_2; pfam07883
351746011080	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746011081	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011082	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746011083	dimerization interface [polypeptide binding]; other site
351746011084	substrate binding pocket [chemical binding]; other site
351746011085	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
351746011086	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06463
351746011087	putative NAD(P) binding site [chemical binding]; other site
351746011088	putative active site [active]
351746011089	Uncharacterized conserved protein [Function unknown]; Region: COG3791
351746011090	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011091	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746011092	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011093	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
351746011094	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746011095	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746011096	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
351746011097	Chorismate mutase type II; Region: CM_2; smart00830
351746011098	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351746011099	protein binding site [polypeptide binding]; other site
351746011100	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
351746011101	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
351746011102	FMN binding site [chemical binding]; other site
351746011103	active site
351746011104	catalytic residues [active]
351746011105	substrate binding site [chemical binding]; other site
351746011106	transaldolase-like protein; Provisional; Region: PTZ00411
351746011107	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
351746011108	active site
351746011109	dimer interface [polypeptide binding]; other site
351746011110	catalytic residue [active]
351746011111	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
351746011112	metal binding site [ion binding]; metal-binding site
351746011113	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
351746011114	putative active site [active]
351746011115	putative metal binding site [ion binding]; other site
351746011116	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
351746011117	anti sigma factor interaction site; other site
351746011118	regulatory phosphorylation site [posttranslational modification]; other site
351746011119	Response regulator receiver domain; Region: Response_reg; pfam00072
351746011120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011121	active site
351746011122	phosphorylation site [posttranslational modification]
351746011123	intermolecular recognition site; other site
351746011124	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
351746011125	dimerization interface [polypeptide binding]; other site
351746011126	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
351746011127	PilZ domain; Region: PilZ; pfam07238
351746011128	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
351746011129	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
351746011130	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
351746011131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
351746011132	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
351746011133	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
351746011134	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
351746011135	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
351746011136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011137	active site
351746011138	phosphorylation site [posttranslational modification]
351746011139	intermolecular recognition site; other site
351746011140	dimerization interface [polypeptide binding]; other site
351746011141	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746011142	DNA binding site [nucleotide binding]
351746011143	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
351746011144	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746011145	dimerization interface [polypeptide binding]; other site
351746011146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746011147	dimer interface [polypeptide binding]; other site
351746011148	phosphorylation site [posttranslational modification]
351746011149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746011150	ATP binding site [chemical binding]; other site
351746011151	Mg2+ binding site [ion binding]; other site
351746011152	G-X-G motif; other site
351746011153	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
351746011154	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351746011155	FtsX-like permease family; Region: FtsX; pfam02687
351746011156	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
351746011157	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351746011158	Walker A/P-loop; other site
351746011159	ATP binding site [chemical binding]; other site
351746011160	Q-loop/lid; other site
351746011161	ABC transporter signature motif; other site
351746011162	Walker B; other site
351746011163	D-loop; other site
351746011164	H-loop/switch region; other site
351746011165	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
351746011166	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351746011167	FtsX-like permease family; Region: FtsX; pfam02687
351746011168	PilZ domain; Region: PilZ; pfam07238
351746011169	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
351746011170	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
351746011171	active site
351746011172	catalytic site [active]
351746011173	metal binding site [ion binding]; metal-binding site
351746011174	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
351746011175	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746011176	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351746011177	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
351746011178	ApbE family; Region: ApbE; pfam02424
351746011179	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
351746011180	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
351746011181	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
351746011182	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
351746011183	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
351746011184	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746011185	ATP binding site [chemical binding]; other site
351746011186	putative Mg++ binding site [ion binding]; other site
351746011187	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746011188	nucleotide binding region [chemical binding]; other site
351746011189	ATP-binding site [chemical binding]; other site
351746011190	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
351746011191	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
351746011192	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
351746011193	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
351746011194	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746011195	ATP binding site [chemical binding]; other site
351746011196	putative Mg++ binding site [ion binding]; other site
351746011197	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746011198	nucleotide binding region [chemical binding]; other site
351746011199	ATP-binding site [chemical binding]; other site
351746011200	beta-hexosaminidase; Provisional; Region: PRK05337
351746011201	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
351746011202	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746011203	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746011204	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
351746011205	LexA repressor; Validated; Region: PRK00215
351746011206	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
351746011207	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746011208	Catalytic site [active]
351746011209	Cell division inhibitor SulA; Region: SulA; cl01880
351746011210	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
351746011211	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
351746011212	active site
351746011213	interdomain interaction site; other site
351746011214	putative metal-binding site [ion binding]; other site
351746011215	nucleotide binding site [chemical binding]; other site
351746011216	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
351746011217	domain I; other site
351746011218	DNA binding groove [nucleotide binding]
351746011219	phosphate binding site [ion binding]; other site
351746011220	domain II; other site
351746011221	domain III; other site
351746011222	nucleotide binding site [chemical binding]; other site
351746011223	catalytic site [active]
351746011224	domain IV; other site
351746011225	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
351746011226	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
351746011227	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
351746011228	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
351746011229	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
351746011230	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
351746011231	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746011232	dimer interface [polypeptide binding]; other site
351746011233	active site
351746011234	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
351746011235	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746011236	substrate binding site [chemical binding]; other site
351746011237	oxyanion hole (OAH) forming residues; other site
351746011238	trimer interface [polypeptide binding]; other site
351746011239	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
351746011240	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746011241	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746011242	Ligand Binding Site [chemical binding]; other site
351746011243	ABC transporter ATPase component; Reviewed; Region: PRK11147
351746011244	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746011245	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746011246	ABC transporter; Region: ABC_tran_2; pfam12848
351746011247	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
351746011248	lytic murein transglycosylase; Provisional; Region: PRK11619
351746011249	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746011250	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746011251	catalytic residue [active]
351746011252	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
351746011253	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
351746011254	MOSC domain; Region: MOSC; pfam03473
351746011255	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351746011256	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746011257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011258	active site
351746011259	phosphorylation site [posttranslational modification]
351746011260	intermolecular recognition site; other site
351746011261	dimerization interface [polypeptide binding]; other site
351746011262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
351746011263	Histidine kinase; Region: HisKA_3; pfam07730
351746011264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746011265	ATP binding site [chemical binding]; other site
351746011266	Mg2+ binding site [ion binding]; other site
351746011267	G-X-G motif; other site
351746011268	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746011269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011270	active site
351746011271	phosphorylation site [posttranslational modification]
351746011272	intermolecular recognition site; other site
351746011273	dimerization interface [polypeptide binding]; other site
351746011274	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746011275	DNA binding residues [nucleotide binding]
351746011276	dimerization interface [polypeptide binding]; other site
351746011277	lipid kinase; Reviewed; Region: PRK13054
351746011278	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
351746011279	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746011280	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
351746011281	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
351746011282	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
351746011283	dimer interface [polypeptide binding]; other site
351746011284	putative functional site; other site
351746011285	putative MPT binding site; other site
351746011286	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
351746011287	MPT binding site; other site
351746011288	trimer interface [polypeptide binding]; other site
351746011289	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
351746011290	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
351746011291	dimerization interface [polypeptide binding]; other site
351746011292	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746011293	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746011294	dimer interface [polypeptide binding]; other site
351746011295	putative CheW interface [polypeptide binding]; other site
351746011296	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
351746011297	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746011298	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746011299	Walker A/P-loop; other site
351746011300	ATP binding site [chemical binding]; other site
351746011301	Q-loop/lid; other site
351746011302	ABC transporter signature motif; other site
351746011303	Walker B; other site
351746011304	D-loop; other site
351746011305	H-loop/switch region; other site
351746011306	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
351746011307	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
351746011308	ligand binding site [chemical binding]; other site
351746011309	NAD binding site [chemical binding]; other site
351746011310	catalytic site [active]
351746011311	homodimer interface [polypeptide binding]; other site
351746011312	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
351746011313	CPxP  motif; other site
351746011314	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
351746011315	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
351746011316	aconitate hydratase; Validated; Region: PRK09277
351746011317	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
351746011318	substrate binding site [chemical binding]; other site
351746011319	ligand binding site [chemical binding]; other site
351746011320	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
351746011321	substrate binding site [chemical binding]; other site
351746011322	PAS domain; Region: PAS_9; pfam13426
351746011323	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011324	putative active site [active]
351746011325	heme pocket [chemical binding]; other site
351746011326	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746011327	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746011328	dimer interface [polypeptide binding]; other site
351746011329	putative CheW interface [polypeptide binding]; other site
351746011330	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
351746011331	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
351746011332	active site
351746011333	Peptidase M15; Region: Peptidase_M15_3; pfam08291
351746011334	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
351746011335	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
351746011336	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
351746011337	Predicted membrane protein [Function unknown]; Region: COG5393
351746011338	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
351746011339	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
351746011340	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746011341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011342	active site
351746011343	phosphorylation site [posttranslational modification]
351746011344	intermolecular recognition site; other site
351746011345	dimerization interface [polypeptide binding]; other site
351746011346	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746011347	DNA binding residues [nucleotide binding]
351746011348	dimerization interface [polypeptide binding]; other site
351746011349	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
351746011350	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746011351	substrate binding pocket [chemical binding]; other site
351746011352	membrane-bound complex binding site; other site
351746011353	hinge residues; other site
351746011354	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746011355	substrate binding pocket [chemical binding]; other site
351746011356	membrane-bound complex binding site; other site
351746011357	hinge residues; other site
351746011358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011359	putative active site [active]
351746011360	heme pocket [chemical binding]; other site
351746011361	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746011362	dimer interface [polypeptide binding]; other site
351746011363	phosphorylation site [posttranslational modification]
351746011364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746011365	ATP binding site [chemical binding]; other site
351746011366	Mg2+ binding site [ion binding]; other site
351746011367	G-X-G motif; other site
351746011368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011369	active site
351746011370	phosphorylation site [posttranslational modification]
351746011371	intermolecular recognition site; other site
351746011372	dimerization interface [polypeptide binding]; other site
351746011373	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
351746011374	putative binding surface; other site
351746011375	active site
351746011376	hypothetical protein; Provisional; Region: PRK11702
351746011377	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
351746011378	CHASE domain; Region: CHASE; pfam03924
351746011379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011380	PAS domain; Region: PAS_9; pfam13426
351746011381	putative active site [active]
351746011382	heme pocket [chemical binding]; other site
351746011383	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746011384	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746011385	metal binding site [ion binding]; metal-binding site
351746011386	active site
351746011387	I-site; other site
351746011388	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
351746011389	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
351746011390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351746011391	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746011392	S-adenosylmethionine binding site [chemical binding]; other site
351746011393	Ribosome modulation factor; Region: RMF; pfam04957
351746011394	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
351746011395	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
351746011396	quinone interaction residues [chemical binding]; other site
351746011397	active site
351746011398	catalytic residues [active]
351746011399	FMN binding site [chemical binding]; other site
351746011400	substrate binding site [chemical binding]; other site
351746011401	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
351746011402	NMT1-like family; Region: NMT1_2; pfam13379
351746011403	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
351746011404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011405	active site
351746011406	phosphorylation site [posttranslational modification]
351746011407	intermolecular recognition site; other site
351746011408	dimerization interface [polypeptide binding]; other site
351746011409	ANTAR domain; Region: ANTAR; pfam03861
351746011410	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
351746011411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746011412	putative substrate translocation pore; other site
351746011413	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
351746011414	active site
351746011415	Catalytic domain of Protein Kinases; Region: PKc; cd00180
351746011416	active site
351746011417	ATP binding site [chemical binding]; other site
351746011418	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
351746011419	substrate binding site [chemical binding]; other site
351746011420	activation loop (A-loop); other site
351746011421	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
351746011422	active site
351746011423	SAM binding site [chemical binding]; other site
351746011424	homodimer interface [polypeptide binding]; other site
351746011425	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
351746011426	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746011427	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746011428	ligand binding site [chemical binding]; other site
351746011429	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
351746011430	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746011431	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746011432	DNA binding residues [nucleotide binding]
351746011433	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
351746011434	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
351746011435	Cl binding site [ion binding]; other site
351746011436	oligomer interface [polypeptide binding]; other site
351746011437	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
351746011438	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746011439	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746011440	phosphoenolpyruvate synthase; Validated; Region: PRK06464
351746011441	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
351746011442	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
351746011443	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
351746011444	PEP synthetase regulatory protein; Provisional; Region: PRK05339
351746011445	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
351746011446	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
351746011447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011448	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746011449	dimerization interface [polypeptide binding]; other site
351746011450	diaminopimelate decarboxylase; Provisional; Region: PRK11165
351746011451	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
351746011452	active site
351746011453	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746011454	substrate binding site [chemical binding]; other site
351746011455	catalytic residues [active]
351746011456	dimer interface [polypeptide binding]; other site
351746011457	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
351746011458	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746011459	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
351746011460	DNA binding residues [nucleotide binding]
351746011461	fec operon regulator FecR; Reviewed; Region: PRK09774
351746011462	FecR protein; Region: FecR; pfam04773
351746011463	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746011464	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
351746011465	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746011466	N-terminal plug; other site
351746011467	ligand-binding site [chemical binding]; other site
351746011468	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011470	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
351746011471	putative substrate binding pocket [chemical binding]; other site
351746011472	putative dimerization interface [polypeptide binding]; other site
351746011473	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
351746011474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746011475	Coenzyme A binding pocket [chemical binding]; other site
351746011476	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746011477	Helix-turn-helix domain; Region: HTH_18; pfam12833
351746011478	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011479	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
351746011480	Cupin domain; Region: Cupin_2; cl17218
351746011481	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746011482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011483	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
351746011484	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746011485	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
351746011486	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746011487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746011488	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
351746011489	putative substrate translocation pore; other site
351746011490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746011491	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
351746011492	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746011493	DNA-binding site [nucleotide binding]; DNA binding site
351746011494	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
351746011495	multidrug efflux protein; Reviewed; Region: PRK09579
351746011496	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746011497	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746011498	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746011499	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
351746011500	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
351746011501	DNA binding residues [nucleotide binding]
351746011502	dimer interface [polypeptide binding]; other site
351746011503	[2Fe-2S] cluster binding site [ion binding]; other site
351746011504	CsbD-like; Region: CsbD; pfam05532
351746011505	outer membrane porin, OprD family; Region: OprD; pfam03573
351746011506	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
351746011507	Citrate transporter; Region: CitMHS; pfam03600
351746011508	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
351746011509	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746011510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
351746011511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011513	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
351746011514	putative dimerization interface [polypeptide binding]; other site
351746011515	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746011516	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
351746011517	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
351746011518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746011519	motif II; other site
351746011520	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
351746011521	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
351746011522	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
351746011523	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746011524	dimer interface [polypeptide binding]; other site
351746011525	active site
351746011526	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
351746011527	active site
351746011528	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351746011529	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
351746011530	putative active site [active]
351746011531	metal binding site [ion binding]; metal-binding site
351746011532	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
351746011533	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746011534	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746011535	active site
351746011536	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746011537	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
351746011538	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
351746011539	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746011540	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
351746011541	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011543	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746011544	dimerization interface [polypeptide binding]; other site
351746011545	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
351746011546	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351746011547	Domain of unknown function (DUF202); Region: DUF202; pfam02656
351746011548	Domain of unknown function (DUF202); Region: DUF202; cl09954
351746011549	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
351746011550	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
351746011551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011553	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
351746011554	putative dimerization interface [polypeptide binding]; other site
351746011555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746011556	D-galactonate transporter; Region: 2A0114; TIGR00893
351746011557	putative substrate translocation pore; other site
351746011558	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746011559	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
351746011560	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
351746011561	active site
351746011562	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
351746011563	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351746011564	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
351746011565	acyl-activating enzyme (AAE) consensus motif; other site
351746011566	acyl-activating enzyme (AAE) consensus motif; other site
351746011567	putative AMP binding site [chemical binding]; other site
351746011568	putative active site [active]
351746011569	putative CoA binding site [chemical binding]; other site
351746011570	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
351746011571	intersubunit interface [polypeptide binding]; other site
351746011572	active site
351746011573	Zn2+ binding site [ion binding]; other site
351746011574	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
351746011575	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
351746011576	inhibitor site; inhibition site
351746011577	active site
351746011578	dimer interface [polypeptide binding]; other site
351746011579	catalytic residue [active]
351746011580	benzoate transporter; Region: benE; TIGR00843
351746011581	Benzoate membrane transport protein; Region: BenE; pfam03594
351746011582	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
351746011583	MoxR-like ATPases [General function prediction only]; Region: COG0714
351746011584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746011585	Walker A motif; other site
351746011586	ATP binding site [chemical binding]; other site
351746011587	Walker B motif; other site
351746011588	arginine finger; other site
351746011589	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
351746011590	Protein of unknown function DUF58; Region: DUF58; pfam01882
351746011591	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
351746011592	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
351746011593	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
351746011594	metal ion-dependent adhesion site (MIDAS); other site
351746011595	von Willebrand factor type A domain; Region: VWA_2; pfam13519
351746011596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746011597	Tetratricopeptide repeat; Region: TPR_16; pfam13432
351746011598	TPR motif; other site
351746011599	binding surface
351746011600	Oxygen tolerance; Region: BatD; pfam13584
351746011601	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351746011602	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
351746011603	exonuclease subunit SbcD; Provisional; Region: PRK10966
351746011604	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
351746011605	active site
351746011606	metal binding site [ion binding]; metal-binding site
351746011607	DNA binding site [nucleotide binding]
351746011608	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
351746011609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746011610	AAA domain; Region: AAA_23; pfam13476
351746011611	Walker A/P-loop; other site
351746011612	ATP binding site [chemical binding]; other site
351746011613	Q-loop/lid; other site
351746011614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746011615	ABC transporter signature motif; other site
351746011616	Walker B; other site
351746011617	D-loop; other site
351746011618	H-loop/switch region; other site
351746011619	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746011620	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
351746011621	putative GSH binding site (G-site) [chemical binding]; other site
351746011622	active site cysteine [active]
351746011623	putative C-terminal domain interface [polypeptide binding]; other site
351746011624	putative dimer interface [polypeptide binding]; other site
351746011625	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
351746011626	putative N-terminal domain interface [polypeptide binding]; other site
351746011627	putative dimer interface [polypeptide binding]; other site
351746011628	putative substrate binding pocket (H-site) [chemical binding]; other site
351746011629	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
351746011630	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
351746011631	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
351746011632	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
351746011633	aminopeptidase N; Provisional; Region: pepN; PRK14015
351746011634	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
351746011635	active site
351746011636	Zn binding site [ion binding]; other site
351746011637	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
351746011638	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
351746011639	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
351746011640	Rhomboid family; Region: Rhomboid; pfam01694
351746011641	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
351746011642	active site
351746011643	metal binding site [ion binding]; metal-binding site
351746011644	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
351746011645	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
351746011646	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
351746011647	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
351746011648	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
351746011649	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
351746011650	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
351746011651	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
351746011652	active site
351746011653	FMN binding site [chemical binding]; other site
351746011654	2,4-decadienoyl-CoA binding site; other site
351746011655	catalytic residue [active]
351746011656	4Fe-4S cluster binding site [ion binding]; other site
351746011657	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
351746011658	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746011659	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
351746011660	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746011661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011662	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
351746011663	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
351746011664	putative NAD(P) binding site [chemical binding]; other site
351746011665	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
351746011666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746011667	NAD(P) binding site [chemical binding]; other site
351746011668	active site
351746011669	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
351746011670	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746011671	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011672	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011673	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011674	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011675	LysR substrate binding domain; Region: LysR_substrate; pfam03466
351746011676	dimerization interface [polypeptide binding]; other site
351746011677	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
351746011678	classical (c) SDRs; Region: SDR_c; cd05233
351746011679	NAD(P) binding site [chemical binding]; other site
351746011680	active site
351746011681	Uncharacterized conserved protein [Function unknown]; Region: COG1359
351746011682	short chain dehydrogenase; Provisional; Region: PRK06180
351746011683	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
351746011684	NADP binding site [chemical binding]; other site
351746011685	active site
351746011686	steroid binding site; other site
351746011687	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
351746011688	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
351746011689	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
351746011690	Fimbrial protein; Region: Fimbrial; pfam00419
351746011691	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351746011692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746011693	dimer interface [polypeptide binding]; other site
351746011694	phosphorylation site [posttranslational modification]
351746011695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746011696	ATP binding site [chemical binding]; other site
351746011697	Mg2+ binding site [ion binding]; other site
351746011698	G-X-G motif; other site
351746011699	Response regulator receiver domain; Region: Response_reg; pfam00072
351746011700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011701	active site
351746011702	phosphorylation site [posttranslational modification]
351746011703	intermolecular recognition site; other site
351746011704	dimerization interface [polypeptide binding]; other site
351746011705	Response regulator receiver domain; Region: Response_reg; pfam00072
351746011706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011707	active site
351746011708	phosphorylation site [posttranslational modification]
351746011709	intermolecular recognition site; other site
351746011710	dimerization interface [polypeptide binding]; other site
351746011711	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746011712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746011713	dimer interface [polypeptide binding]; other site
351746011714	phosphorylation site [posttranslational modification]
351746011715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746011716	ATP binding site [chemical binding]; other site
351746011717	Mg2+ binding site [ion binding]; other site
351746011718	G-X-G motif; other site
351746011719	Response regulator receiver domain; Region: Response_reg; pfam00072
351746011720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011721	active site
351746011722	phosphorylation site [posttranslational modification]
351746011723	intermolecular recognition site; other site
351746011724	dimerization interface [polypeptide binding]; other site
351746011725	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746011726	putative binding surface; other site
351746011727	active site
351746011728	transcriptional regulator RcsB; Provisional; Region: PRK10840
351746011729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746011730	active site
351746011731	phosphorylation site [posttranslational modification]
351746011732	intermolecular recognition site; other site
351746011733	dimerization interface [polypeptide binding]; other site
351746011734	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746011735	DNA binding residues [nucleotide binding]
351746011736	dimerization interface [polypeptide binding]; other site
351746011737	Fimbrial protein; Region: Fimbrial; pfam00419
351746011738	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
351746011739	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
351746011740	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
351746011741	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
351746011742	PapC N-terminal domain; Region: PapC_N; pfam13954
351746011743	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
351746011744	PapC C-terminal domain; Region: PapC_C; pfam13953
351746011745	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
351746011746	active site
351746011747	catalytic triad [active]
351746011748	Predicted amidohydrolase [General function prediction only]; Region: COG0388
351746011749	dimer interface [polypeptide binding]; other site
351746011750	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746011751	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746011752	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746011753	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
351746011754	oxidoreductase; Validated; Region: PRK05717
351746011755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746011756	NAD(P) binding site [chemical binding]; other site
351746011757	active site
351746011758	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
351746011759	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351746011760	homodimer interface [polypeptide binding]; other site
351746011761	substrate-cofactor binding pocket; other site
351746011762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746011763	catalytic residue [active]
351746011764	amidophosphoribosyltransferase; Provisional; Region: PRK09246
351746011765	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
351746011766	active site
351746011767	tetramer interface [polypeptide binding]; other site
351746011768	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746011769	active site
351746011770	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
351746011771	Colicin V production protein; Region: Colicin_V; cl00567
351746011772	Sporulation related domain; Region: SPOR; pfam05036
351746011773	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
351746011774	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351746011775	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
351746011776	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
351746011777	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
351746011778	active site
351746011779	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
351746011780	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
351746011781	dimerization interface 3.5A [polypeptide binding]; other site
351746011782	active site
351746011783	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351746011784	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
351746011785	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
351746011786	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351746011787	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
351746011788	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351746011789	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
351746011790	tartrate dehydrogenase; Region: TTC; TIGR02089
351746011791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746011792	S-adenosylmethionine binding site [chemical binding]; other site
351746011793	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
351746011794	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
351746011795	substrate binding site [chemical binding]; other site
351746011796	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
351746011797	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
351746011798	substrate binding site [chemical binding]; other site
351746011799	ligand binding site [chemical binding]; other site
351746011800	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746011801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746011802	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746011803	dimerization interface [polypeptide binding]; other site
351746011804	PAS fold; Region: PAS_3; pfam08447
351746011805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011806	putative active site [active]
351746011807	heme pocket [chemical binding]; other site
351746011808	PAS domain S-box; Region: sensory_box; TIGR00229
351746011809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011810	putative active site [active]
351746011811	PAS fold; Region: PAS_3; pfam08447
351746011812	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
351746011813	PAS domain S-box; Region: sensory_box; TIGR00229
351746011814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011815	putative active site [active]
351746011816	heme pocket [chemical binding]; other site
351746011817	PAS domain S-box; Region: sensory_box; TIGR00229
351746011818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746011819	putative active site [active]
351746011820	heme pocket [chemical binding]; other site
351746011821	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746011822	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746011823	metal binding site [ion binding]; metal-binding site
351746011824	active site
351746011825	I-site; other site
351746011826	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746011827	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
351746011828	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
351746011829	putative dimer interface [polypeptide binding]; other site
351746011830	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
351746011831	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
351746011832	FMN binding site [chemical binding]; other site
351746011833	active site
351746011834	catalytic residues [active]
351746011835	substrate binding site [chemical binding]; other site
351746011836	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
351746011837	active site
351746011838	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746011839	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746011840	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746011841	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
351746011842	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351746011843	active site
351746011844	HIGH motif; other site
351746011845	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351746011846	active site
351746011847	KMSKS motif; other site
351746011848	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
351746011849	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746011850	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
351746011851	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746011852	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
351746011853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746011854	putative substrate translocation pore; other site
351746011855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746011856	excinuclease ABC subunit B; Provisional; Region: PRK05298
351746011857	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746011858	ATP binding site [chemical binding]; other site
351746011859	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746011860	nucleotide binding region [chemical binding]; other site
351746011861	ATP-binding site [chemical binding]; other site
351746011862	Ultra-violet resistance protein B; Region: UvrB; pfam12344
351746011863	UvrB/uvrC motif; Region: UVR; pfam02151
351746011864	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
351746011865	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746011866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746011867	homodimer interface [polypeptide binding]; other site
351746011868	catalytic residue [active]
351746011869	Cupin domain; Region: Cupin_2; pfam07883
351746011870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
351746011871	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
351746011872	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
351746011873	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746011874	FeS/SAM binding site; other site
351746011875	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
351746011876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746011877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746011878	WHG domain; Region: WHG; pfam13305
351746011879	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
351746011880	active site
351746011881	DNA polymerase III subunit delta'; Validated; Region: PRK05707
351746011882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746011883	Walker A motif; other site
351746011884	ATP binding site [chemical binding]; other site
351746011885	Walker B motif; other site
351746011886	arginine finger; other site
351746011887	thymidylate kinase; Validated; Region: tmk; PRK00698
351746011888	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
351746011889	TMP-binding site; other site
351746011890	ATP-binding site [chemical binding]; other site
351746011891	YceG-like family; Region: YceG; pfam02618
351746011892	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
351746011893	dimerization interface [polypeptide binding]; other site
351746011894	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
351746011895	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
351746011896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746011897	catalytic residue [active]
351746011898	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
351746011899	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
351746011900	dimer interface [polypeptide binding]; other site
351746011901	active site
351746011902	acyl carrier protein; Provisional; Region: acpP; PRK00982
351746011903	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
351746011904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746011905	NAD(P) binding site [chemical binding]; other site
351746011906	active site
351746011907	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
351746011908	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
351746011909	putative phosphate acyltransferase; Provisional; Region: PRK05331
351746011910	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
351746011911	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
351746011912	Maf-like protein; Region: Maf; pfam02545
351746011913	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
351746011914	active site
351746011915	dimer interface [polypeptide binding]; other site
351746011916	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
351746011917	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
351746011918	tandem repeat interface [polypeptide binding]; other site
351746011919	oligomer interface [polypeptide binding]; other site
351746011920	active site residues [active]
351746011921	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
351746011922	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746011923	motif II; other site
351746011924	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
351746011925	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746011926	RNA binding surface [nucleotide binding]; other site
351746011927	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
351746011928	active site
351746011929	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
351746011930	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
351746011931	homodimer interface [polypeptide binding]; other site
351746011932	oligonucleotide binding site [chemical binding]; other site
351746011933	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
351746011934	FAD binding domain; Region: FAD_binding_4; pfam01565
351746011935	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
351746011936	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
351746011937	Low molecular weight phosphatase family; Region: LMWPc; cd00115
351746011938	active site
351746011939	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
351746011940	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
351746011941	Ligand binding site; other site
351746011942	oligomer interface; other site
351746011943	Uncharacterized conserved protein [Function unknown]; Region: COG2835
351746011944	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
351746011945	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
351746011946	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
351746011947	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
351746011948	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
351746011949	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
351746011950	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
351746011951	Competence protein; Region: Competence; pfam03772
351746011952	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
351746011953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
351746011954	inner membrane transport permease; Provisional; Region: PRK15066
351746011955	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
351746011956	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351746011957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746011958	Walker A/P-loop; other site
351746011959	ATP binding site [chemical binding]; other site
351746011960	Q-loop/lid; other site
351746011961	ABC transporter signature motif; other site
351746011962	Walker B; other site
351746011963	D-loop; other site
351746011964	H-loop/switch region; other site
351746011965	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746011966	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
351746011967	putative C-terminal domain interface [polypeptide binding]; other site
351746011968	putative GSH binding site (G-site) [chemical binding]; other site
351746011969	putative dimer interface [polypeptide binding]; other site
351746011970	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
351746011971	putative N-terminal domain interface [polypeptide binding]; other site
351746011972	putative dimer interface [polypeptide binding]; other site
351746011973	putative substrate binding pocket (H-site) [chemical binding]; other site
351746011974	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
351746011975	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
351746011976	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
351746011977	active site
351746011978	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
351746011979	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
351746011980	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
351746011981	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
351746011982	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
351746011983	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
351746011984	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
351746011985	Autotransporter beta-domain; Region: Autotransporter; pfam03797
351746011986	aspartate aminotransferase; Provisional; Region: PRK05764
351746011987	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
351746011988	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351746011989	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
351746011990	PapC N-terminal domain; Region: PapC_N; pfam13954
351746011991	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
351746011992	PapC C-terminal domain; Region: PapC_C; pfam13953
351746011993	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
351746011994	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
351746011995	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
351746011996	GAF domain; Region: GAF_2; pfam13185
351746011997	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
351746011998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746011999	Walker A motif; other site
351746012000	ATP binding site [chemical binding]; other site
351746012001	Walker B motif; other site
351746012002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746012003	dimer interface [polypeptide binding]; other site
351746012004	phosphorylation site [posttranslational modification]
351746012005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746012006	ATP binding site [chemical binding]; other site
351746012007	Mg2+ binding site [ion binding]; other site
351746012008	G-X-G motif; other site
351746012009	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746012010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746012011	active site
351746012012	phosphorylation site [posttranslational modification]
351746012013	intermolecular recognition site; other site
351746012014	dimerization interface [polypeptide binding]; other site
351746012015	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
351746012016	catalytic residues [active]
351746012017	dimer interface [polypeptide binding]; other site
351746012018	methionine sulfoxide reductase B; Provisional; Region: PRK00222
351746012019	SelR domain; Region: SelR; pfam01641
351746012020	aminotransferase AlaT; Validated; Region: PRK09265
351746012021	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746012022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746012023	homodimer interface [polypeptide binding]; other site
351746012024	catalytic residue [active]
351746012025	heat shock protein HtpX; Provisional; Region: PRK05457
351746012026	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
351746012027	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
351746012028	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
351746012029	putative active site [active]
351746012030	metal binding site [ion binding]; metal-binding site
351746012031	helicase 45; Provisional; Region: PTZ00424
351746012032	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
351746012033	ATP binding site [chemical binding]; other site
351746012034	Mg++ binding site [ion binding]; other site
351746012035	motif III; other site
351746012036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746012037	nucleotide binding region [chemical binding]; other site
351746012038	ATP-binding site [chemical binding]; other site
351746012039	DbpA RNA binding domain; Region: DbpA; pfam03880
351746012040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746012041	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
351746012042	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
351746012043	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746012044	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012045	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746012046	dimerization interface [polypeptide binding]; other site
351746012047	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746012048	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746012049	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012050	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746012051	putative effector binding pocket; other site
351746012052	dimerization interface [polypeptide binding]; other site
351746012053	Transcriptional regulators [Transcription]; Region: MarR; COG1846
351746012054	MarR family; Region: MarR; pfam01047
351746012055	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
351746012056	elongation factor P; Validated; Region: PRK00529
351746012057	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
351746012058	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
351746012059	RNA binding site [nucleotide binding]; other site
351746012060	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
351746012061	RNA binding site [nucleotide binding]; other site
351746012062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
351746012063	conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837
351746012064	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
351746012065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746012066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012067	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746012068	putative effector binding pocket; other site
351746012069	dimerization interface [polypeptide binding]; other site
351746012070	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
351746012071	classical (c) SDRs; Region: SDR_c; cd05233
351746012072	NAD(P) binding site [chemical binding]; other site
351746012073	active site
351746012074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746012075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012076	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
351746012077	putative dimerization interface [polypeptide binding]; other site
351746012078	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
351746012079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746012080	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746012081	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746012082	N-terminal plug; other site
351746012083	ligand-binding site [chemical binding]; other site
351746012084	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
351746012085	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746012086	substrate binding site [chemical binding]; other site
351746012087	oxyanion hole (OAH) forming residues; other site
351746012088	trimer interface [polypeptide binding]; other site
351746012089	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
351746012090	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
351746012091	putative acyl-acceptor binding pocket; other site
351746012092	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
351746012093	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
351746012094	oligomer interface [polypeptide binding]; other site
351746012095	metal binding site [ion binding]; metal-binding site
351746012096	metal binding site [ion binding]; metal-binding site
351746012097	putative Cl binding site [ion binding]; other site
351746012098	basic sphincter; other site
351746012099	hydrophobic gate; other site
351746012100	periplasmic entrance; other site
351746012101	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
351746012102	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
351746012103	catalytic triad [active]
351746012104	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
351746012105	Cytochrome c; Region: Cytochrom_C; pfam00034
351746012106	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
351746012107	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
351746012108	Sulfatase; Region: Sulfatase; pfam00884
351746012109	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
351746012110	ZIP Zinc transporter; Region: Zip; pfam02535
351746012111	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
351746012112	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
351746012113	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
351746012114	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
351746012115	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
351746012116	Cupin domain; Region: Cupin_2; cl17218
351746012117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746012118	putative substrate translocation pore; other site
351746012119	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
351746012120	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
351746012121	Tetramer interface [polypeptide binding]; other site
351746012122	active site
351746012123	FMN-binding site [chemical binding]; other site
351746012124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746012125	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351746012126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351746012127	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351746012128	HemK family putative methylases; Region: hemK_fam; TIGR00536
351746012129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746012130	S-adenosylmethionine binding site [chemical binding]; other site
351746012131	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
351746012132	Isochorismatase family; Region: Isochorismatase; pfam00857
351746012133	catalytic triad [active]
351746012134	conserved cis-peptide bond; other site
351746012135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
351746012136	Smr domain; Region: Smr; pfam01713
351746012137	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
351746012138	GTP cyclohydrolase I; Provisional; Region: PLN03044
351746012139	active site
351746012140	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
351746012141	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746012142	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
351746012143	putative C-terminal domain interface [polypeptide binding]; other site
351746012144	putative GSH binding site (G-site) [chemical binding]; other site
351746012145	putative dimer interface [polypeptide binding]; other site
351746012146	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
351746012147	N-terminal domain interface [polypeptide binding]; other site
351746012148	dimer interface [polypeptide binding]; other site
351746012149	substrate binding pocket (H-site) [chemical binding]; other site
351746012150	benzoate transporter; Region: benE; TIGR00843
351746012151	Benzoate membrane transport protein; Region: BenE; pfam03594
351746012152	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746012153	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746012154	dimer interface [polypeptide binding]; other site
351746012155	putative CheW interface [polypeptide binding]; other site
351746012156	short chain dehydrogenase; Provisional; Region: PRK06172
351746012157	classical (c) SDRs; Region: SDR_c; cd05233
351746012158	NAD(P) binding site [chemical binding]; other site
351746012159	active site
351746012160	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
351746012161	Prostaglandin dehydrogenases; Region: PGDH; cd05288
351746012162	NAD(P) binding site [chemical binding]; other site
351746012163	substrate binding site [chemical binding]; other site
351746012164	dimer interface [polypeptide binding]; other site
351746012165	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
351746012166	active site
351746012167	dimer interface [polypeptide binding]; other site
351746012168	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
351746012169	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
351746012170	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746012171	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
351746012172	trimer interface [polypeptide binding]; other site
351746012173	active site
351746012174	substrate binding site [chemical binding]; other site
351746012175	CoA binding site [chemical binding]; other site
351746012176	ABC-2 type transporter; Region: ABC2_membrane; cl17235
351746012177	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
351746012178	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
351746012179	Walker A/P-loop; other site
351746012180	ATP binding site [chemical binding]; other site
351746012181	Q-loop/lid; other site
351746012182	ABC transporter signature motif; other site
351746012183	Walker B; other site
351746012184	D-loop; other site
351746012185	H-loop/switch region; other site
351746012186	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
351746012187	Chain length determinant protein; Region: Wzz; cl15801
351746012188	polysaccharide export protein Wza; Provisional; Region: PRK15078
351746012189	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
351746012190	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
351746012191	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
351746012192	active site
351746012193	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
351746012194	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
351746012195	TPR repeat; Region: TPR_11; pfam13414
351746012196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746012197	TPR motif; other site
351746012198	binding surface
351746012199	UDP-glucose 4-epimerase; Region: PLN02240
351746012200	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
351746012201	NAD binding site [chemical binding]; other site
351746012202	homodimer interface [polypeptide binding]; other site
351746012203	active site
351746012204	substrate binding site [chemical binding]; other site
351746012205	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457
351746012206	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
351746012207	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
351746012208	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
351746012209	Ligand binding site; other site
351746012210	oligomer interface; other site
351746012211	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
351746012212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746012213	active site
351746012214	motif I; other site
351746012215	motif II; other site
351746012216	KpsF/GutQ family protein; Region: kpsF; TIGR00393
351746012217	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
351746012218	putative active site [active]
351746012219	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
351746012220	Phosphotransferase enzyme family; Region: APH; pfam01636
351746012221	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
351746012222	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
351746012223	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
351746012224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746012225	NAD(P) binding site [chemical binding]; other site
351746012226	active site
351746012227	Sulfatase; Region: Sulfatase; pfam00884
351746012228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746012229	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
351746012230	Coenzyme A binding pocket [chemical binding]; other site
351746012231	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
351746012232	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
351746012233	Transposase IS200 like; Region: Y1_Tnp; pfam01797
351746012234	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
351746012235	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
351746012236	substrate-cofactor binding pocket; other site
351746012237	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746012238	catalytic residue [active]
351746012239	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
351746012240	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
351746012241	active site
351746012242	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
351746012243	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
351746012244	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746012245	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
351746012246	Enoylreductase; Region: PKS_ER; smart00829
351746012247	NAD(P) binding site [chemical binding]; other site
351746012248	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
351746012249	KR domain; Region: KR; pfam08659
351746012250	putative NADP binding site [chemical binding]; other site
351746012251	active site
351746012252	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
351746012253	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
351746012254	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
351746012255	Probable Catalytic site; other site
351746012256	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
351746012257	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
351746012258	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
351746012259	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
351746012260	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
351746012261	Walker A/P-loop; other site
351746012262	ATP binding site [chemical binding]; other site
351746012263	Q-loop/lid; other site
351746012264	ABC transporter signature motif; other site
351746012265	Walker B; other site
351746012266	D-loop; other site
351746012267	H-loop/switch region; other site
351746012268	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
351746012269	putative carbohydrate binding site [chemical binding]; other site
351746012270	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351746012271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746012272	S-adenosylmethionine binding site [chemical binding]; other site
351746012273	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
351746012274	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
351746012275	Probable Catalytic site; other site
351746012276	metal-binding site
351746012277	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746012278	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
351746012279	Probable Catalytic site; other site
351746012280	metal-binding site
351746012281	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
351746012282	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
351746012283	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
351746012284	inhibitor-cofactor binding pocket; inhibition site
351746012285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746012286	catalytic residue [active]
351746012287	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
351746012288	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
351746012289	Ligand binding site; other site
351746012290	Putative Catalytic site; other site
351746012291	DXD motif; other site
351746012292	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
351746012293	putative trimer interface [polypeptide binding]; other site
351746012294	putative active site [active]
351746012295	putative substrate binding site [chemical binding]; other site
351746012296	putative CoA binding site [chemical binding]; other site
351746012297	WxcM-like, C-terminal; Region: FdtA; pfam05523
351746012298	Predicted membrane protein [Function unknown]; Region: COG2246
351746012299	GtrA-like protein; Region: GtrA; pfam04138
351746012300	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
351746012301	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351746012302	active site
351746012303	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
351746012304	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
351746012305	substrate binding site; other site
351746012306	tetramer interface; other site
351746012307	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
351746012308	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
351746012309	NADP binding site [chemical binding]; other site
351746012310	active site
351746012311	putative substrate binding site [chemical binding]; other site
351746012312	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
351746012313	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
351746012314	NAD binding site [chemical binding]; other site
351746012315	substrate binding site [chemical binding]; other site
351746012316	homodimer interface [polypeptide binding]; other site
351746012317	active site
351746012318	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
351746012319	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
351746012320	NAD(P) binding site [chemical binding]; other site
351746012321	homodimer interface [polypeptide binding]; other site
351746012322	substrate binding site [chemical binding]; other site
351746012323	active site
351746012324	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
351746012325	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
351746012326	Mg++ binding site [ion binding]; other site
351746012327	putative catalytic motif [active]
351746012328	putative substrate binding site [chemical binding]; other site
351746012329	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
351746012330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746012331	NAD(P) binding site [chemical binding]; other site
351746012332	active site
351746012333	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
351746012334	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351746012335	Beta-Casp domain; Region: Beta-Casp; smart01027
351746012336	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
351746012337	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351746012338	IHF dimer interface [polypeptide binding]; other site
351746012339	IHF - DNA interface [nucleotide binding]; other site
351746012340	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
351746012341	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
351746012342	RNA binding site [nucleotide binding]; other site
351746012343	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
351746012344	RNA binding site [nucleotide binding]; other site
351746012345	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
351746012346	RNA binding site [nucleotide binding]; other site
351746012347	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351746012348	RNA binding site [nucleotide binding]; other site
351746012349	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351746012350	RNA binding site [nucleotide binding]; other site
351746012351	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
351746012352	RNA binding site [nucleotide binding]; other site
351746012353	cytidylate kinase; Provisional; Region: cmk; PRK00023
351746012354	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
351746012355	CMP-binding site; other site
351746012356	The sites determining sugar specificity; other site
351746012357	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
351746012358	prephenate dehydrogenase; Validated; Region: PRK08507
351746012359	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
351746012360	hinge; other site
351746012361	active site
351746012362	Chorismate mutase type II; Region: CM_2; cl00693
351746012363	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
351746012364	Prephenate dehydratase; Region: PDT; pfam00800
351746012365	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
351746012366	putative L-Phe binding site [chemical binding]; other site
351746012367	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
351746012368	homodimer interface [polypeptide binding]; other site
351746012369	substrate-cofactor binding pocket; other site
351746012370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746012371	catalytic residue [active]
351746012372	DNA gyrase subunit A; Validated; Region: PRK05560
351746012373	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
351746012374	CAP-like domain; other site
351746012375	active site
351746012376	primary dimer interface [polypeptide binding]; other site
351746012377	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351746012378	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351746012379	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351746012380	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351746012381	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351746012382	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351746012383	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
351746012384	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
351746012385	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
351746012386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746012387	S-adenosylmethionine binding site [chemical binding]; other site
351746012388	phosphoglycolate phosphatase; Provisional; Region: PRK13222
351746012389	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351746012390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746012391	motif II; other site
351746012392	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
351746012393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746012394	NAD(P) binding site [chemical binding]; other site
351746012395	active site
351746012396	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
351746012397	PAS domain S-box; Region: sensory_box; TIGR00229
351746012398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746012399	putative active site [active]
351746012400	heme pocket [chemical binding]; other site
351746012401	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746012402	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746012403	metal binding site [ion binding]; metal-binding site
351746012404	active site
351746012405	I-site; other site
351746012406	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746012407	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746012408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746012409	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
351746012410	Walker A/P-loop; other site
351746012411	ATP binding site [chemical binding]; other site
351746012412	Q-loop/lid; other site
351746012413	ABC transporter signature motif; other site
351746012414	Walker B; other site
351746012415	D-loop; other site
351746012416	H-loop/switch region; other site
351746012417	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
351746012418	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
351746012419	catalytic residues [active]
351746012420	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
351746012421	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
351746012422	active site residue [active]
351746012423	BolA-like protein; Region: BolA; pfam01722
351746012424	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
351746012425	fumarate hydratase; Provisional; Region: PRK12425
351746012426	Class II fumarases; Region: Fumarase_classII; cd01362
351746012427	active site
351746012428	tetramer interface [polypeptide binding]; other site
351746012429	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
351746012430	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351746012431	EamA-like transporter family; Region: EamA; pfam00892
351746012432	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
351746012433	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
351746012434	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
351746012435	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
351746012436	Uncharacterized conserved protein [Function unknown]; Region: COG4121
351746012437	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
351746012438	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
351746012439	active site
351746012440	dimer interface [polypeptide binding]; other site
351746012441	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
351746012442	Ligand Binding Site [chemical binding]; other site
351746012443	Molecular Tunnel; other site
351746012444	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
351746012445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746012446	Coenzyme A binding pocket [chemical binding]; other site
351746012447	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351746012448	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
351746012449	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
351746012450	putative oligomer interface [polypeptide binding]; other site
351746012451	putative active site [active]
351746012452	metal binding site [ion binding]; metal-binding site
351746012453	hypothetical protein; Provisional; Region: PRK00304
351746012454	Global regulator protein family; Region: CsrA; pfam02599
351746012455	short chain dehydrogenase; Provisional; Region: PRK05650
351746012456	classical (c) SDRs; Region: SDR_c; cd05233
351746012457	NAD(P) binding site [chemical binding]; other site
351746012458	active site
351746012459	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
351746012460	putative fimbrial protein TcfA; Provisional; Region: PRK15308
351746012461	Baculoviral E56 protein, specific to ODV envelope; Region: Baculo_E56; pfam04639
351746012462	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
351746012463	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
351746012464	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
351746012465	Na binding site [ion binding]; other site
351746012466	Predicted membrane protein [Function unknown]; Region: COG3162
351746012467	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
351746012468	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
351746012469	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
351746012470	VacJ like lipoprotein; Region: VacJ; cl01073
351746012471	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
351746012472	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
351746012473	active site
351746012474	nucleophile elbow; other site
351746012475	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
351746012476	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
351746012477	putative acyl-acceptor binding pocket; other site
351746012478	septum formation inhibitor; Reviewed; Region: minC; PRK00339
351746012479	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
351746012480	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
351746012481	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
351746012482	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
351746012483	Switch I; other site
351746012484	Switch II; other site
351746012485	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
351746012486	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
351746012487	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
351746012488	active site
351746012489	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
351746012490	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
351746012491	active site
351746012492	metal binding site [ion binding]; metal-binding site
351746012493	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
351746012494	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746012495	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746012496	transcriptional regulator protein; Region: phnR; TIGR03337
351746012497	DNA-binding site [nucleotide binding]; DNA binding site
351746012498	UTRA domain; Region: UTRA; pfam07702
351746012499	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
351746012500	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351746012501	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
351746012502	Sulfatase; Region: Sulfatase; cl17466
351746012503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746012504	dimer interface [polypeptide binding]; other site
351746012505	conserved gate region; other site
351746012506	putative PBP binding loops; other site
351746012507	ABC-ATPase subunit interface; other site
351746012508	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746012509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746012510	dimer interface [polypeptide binding]; other site
351746012511	conserved gate region; other site
351746012512	putative PBP binding loops; other site
351746012513	ABC-ATPase subunit interface; other site
351746012514	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
351746012515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746012516	Walker A/P-loop; other site
351746012517	ATP binding site [chemical binding]; other site
351746012518	Q-loop/lid; other site
351746012519	ABC transporter signature motif; other site
351746012520	Walker B; other site
351746012521	D-loop; other site
351746012522	H-loop/switch region; other site
351746012523	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
351746012524	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351746012525	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
351746012526	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
351746012527	NAD(P) binding site [chemical binding]; other site
351746012528	carboxy-terminal protease; Provisional; Region: PRK11186
351746012529	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
351746012530	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
351746012531	protein binding site [polypeptide binding]; other site
351746012532	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
351746012533	Catalytic dyad [active]
351746012534	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
351746012535	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746012536	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
351746012537	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746012538	salt bridge; other site
351746012539	non-specific DNA binding site [nucleotide binding]; other site
351746012540	sequence-specific DNA binding site [nucleotide binding]; other site
351746012541	Uncharacterized conserved protein [Function unknown]; Region: COG3339
351746012542	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
351746012543	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
351746012544	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351746012545	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
351746012546	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012547	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746012548	dimerization interface [polypeptide binding]; other site
351746012549	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746012550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746012551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746012552	D-galactonate transporter; Region: 2A0114; TIGR00893
351746012553	putative substrate translocation pore; other site
351746012554	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
351746012555	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
351746012556	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
351746012557	classical (c) SDRs; Region: SDR_c; cd05233
351746012558	NAD(P) binding site [chemical binding]; other site
351746012559	active site
351746012560	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
351746012561	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
351746012562	putative ligand binding site [chemical binding]; other site
351746012563	NAD binding site [chemical binding]; other site
351746012564	catalytic site [active]
351746012565	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
351746012566	nitrite reductase subunit NirD; Provisional; Region: PRK14989
351746012567	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746012568	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
351746012569	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
351746012570	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
351746012571	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
351746012572	[4Fe-4S] binding site [ion binding]; other site
351746012573	molybdopterin cofactor binding site; other site
351746012574	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
351746012575	molybdopterin cofactor binding site; other site
351746012576	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
351746012577	Flavodoxin; Region: Flavodoxin_1; pfam00258
351746012578	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
351746012579	FAD binding pocket [chemical binding]; other site
351746012580	FAD binding motif [chemical binding]; other site
351746012581	catalytic residues [active]
351746012582	NAD binding pocket [chemical binding]; other site
351746012583	phosphate binding motif [ion binding]; other site
351746012584	beta-alpha-beta structure motif; other site
351746012585	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
351746012586	active site
351746012587	recombination associated protein; Reviewed; Region: rdgC; PRK00321
351746012588	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
351746012589	H+ Antiporter protein; Region: 2A0121; TIGR00900
351746012590	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
351746012591	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
351746012592	putative acyl-acceptor binding pocket; other site
351746012593	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
351746012594	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
351746012595	active site
351746012596	benzoate transport; Region: 2A0115; TIGR00895
351746012597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746012598	putative substrate translocation pore; other site
351746012599	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
351746012600	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746012601	DNA-binding site [nucleotide binding]; DNA binding site
351746012602	UTRA domain; Region: UTRA; pfam07702
351746012603	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746012604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746012605	putative substrate translocation pore; other site
351746012606	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
351746012607	Na binding site [ion binding]; other site
351746012608	PAS domain; Region: PAS; smart00091
351746012609	PAS fold; Region: PAS_7; pfam12860
351746012610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746012611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746012612	dimer interface [polypeptide binding]; other site
351746012613	phosphorylation site [posttranslational modification]
351746012614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746012615	ATP binding site [chemical binding]; other site
351746012616	Mg2+ binding site [ion binding]; other site
351746012617	G-X-G motif; other site
351746012618	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
351746012619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746012620	active site
351746012621	phosphorylation site [posttranslational modification]
351746012622	intermolecular recognition site; other site
351746012623	dimerization interface [polypeptide binding]; other site
351746012624	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
351746012625	RmuC family; Region: RmuC; pfam02646
351746012626	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
351746012627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746012628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012629	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746012630	putative effector binding pocket; other site
351746012631	dimerization interface [polypeptide binding]; other site
351746012632	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
351746012633	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
351746012634	catalytic residues [active]
351746012635	dimer interface [polypeptide binding]; other site
351746012636	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
351746012637	Transcriptional regulators [Transcription]; Region: MarR; COG1846
351746012638	MarR family; Region: MarR_2; pfam12802
351746012639	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351746012640	cobalamin synthase; Reviewed; Region: cobS; PRK00235
351746012641	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
351746012642	catalytic core [active]
351746012643	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
351746012644	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
351746012645	putative dimer interface [polypeptide binding]; other site
351746012646	active site pocket [active]
351746012647	putative cataytic base [active]
351746012648	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
351746012649	homotrimer interface [polypeptide binding]; other site
351746012650	Walker A motif; other site
351746012651	GTP binding site [chemical binding]; other site
351746012652	cobyric acid synthase; Provisional; Region: PRK00784
351746012653	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
351746012654	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
351746012655	catalytic triad [active]
351746012656	threonine-phosphate decarboxylase; Reviewed; Region: PRK05664
351746012657	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
351746012658	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746012659	catalytic residue [active]
351746012660	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
351746012661	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
351746012662	putative FMN binding site [chemical binding]; other site
351746012663	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
351746012664	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351746012665	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
351746012666	catalytic triad [active]
351746012667	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
351746012668	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
351746012669	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
351746012670	Walker A motif; other site
351746012671	homodimer interface [polypeptide binding]; other site
351746012672	ATP binding site [chemical binding]; other site
351746012673	hydroxycobalamin binding site [chemical binding]; other site
351746012674	Walker B motif; other site
351746012675	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
351746012676	NlpC/P60 family; Region: NLPC_P60; pfam00877
351746012677	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
351746012678	NlpC/P60 family; Region: NLPC_P60; pfam00877
351746012679	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
351746012680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746012681	Walker A motif; other site
351746012682	ATP binding site [chemical binding]; other site
351746012683	Walker B motif; other site
351746012684	arginine finger; other site
351746012685	Domain of unknown function DUF20; Region: UPF0118; pfam01594
351746012686	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
351746012687	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
351746012688	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
351746012689	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
351746012690	dimerization interface [polypeptide binding]; other site
351746012691	putative ATP binding site [chemical binding]; other site
351746012692	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
351746012693	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
351746012694	active site
351746012695	substrate binding site [chemical binding]; other site
351746012696	cosubstrate binding site; other site
351746012697	catalytic site [active]
351746012698	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
351746012699	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
351746012700	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
351746012701	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
351746012702	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
351746012703	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
351746012704	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
351746012705	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
351746012706	homodimer interface [polypeptide binding]; other site
351746012707	metal binding site [ion binding]; metal-binding site
351746012708	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
351746012709	homodimer interface [polypeptide binding]; other site
351746012710	active site
351746012711	putative chemical substrate binding site [chemical binding]; other site
351746012712	metal binding site [ion binding]; metal-binding site
351746012713	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
351746012714	HD domain; Region: HD_4; pfam13328
351746012715	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
351746012716	synthetase active site [active]
351746012717	NTP binding site [chemical binding]; other site
351746012718	metal binding site [ion binding]; metal-binding site
351746012719	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
351746012720	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
351746012721	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
351746012722	TRAM domain; Region: TRAM; pfam01938
351746012723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746012724	S-adenosylmethionine binding site [chemical binding]; other site
351746012725	cysteine synthase B; Region: cysM; TIGR01138
351746012726	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
351746012727	dimer interface [polypeptide binding]; other site
351746012728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746012729	catalytic residue [active]
351746012730	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746012731	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746012732	dimerization interface [polypeptide binding]; other site
351746012733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746012734	dimer interface [polypeptide binding]; other site
351746012735	phosphorylation site [posttranslational modification]
351746012736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746012737	ATP binding site [chemical binding]; other site
351746012738	Mg2+ binding site [ion binding]; other site
351746012739	G-X-G motif; other site
351746012740	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746012741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746012742	active site
351746012743	phosphorylation site [posttranslational modification]
351746012744	intermolecular recognition site; other site
351746012745	dimerization interface [polypeptide binding]; other site
351746012746	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746012747	DNA binding site [nucleotide binding]
351746012748	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
351746012749	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746012750	dimerization interface [polypeptide binding]; other site
351746012751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746012752	dimer interface [polypeptide binding]; other site
351746012753	phosphorylation site [posttranslational modification]
351746012754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746012755	ATP binding site [chemical binding]; other site
351746012756	Mg2+ binding site [ion binding]; other site
351746012757	G-X-G motif; other site
351746012758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746012759	active site
351746012760	phosphorylation site [posttranslational modification]
351746012761	intermolecular recognition site; other site
351746012762	dimerization interface [polypeptide binding]; other site
351746012763	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746012764	putative binding surface; other site
351746012765	active site
351746012766	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
351746012767	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
351746012768	putative ligand binding site [chemical binding]; other site
351746012769	putative NAD binding site [chemical binding]; other site
351746012770	catalytic site [active]
351746012771	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
351746012772	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
351746012773	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746012774	catalytic residues [active]
351746012775	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
351746012776	ArsC family; Region: ArsC; pfam03960
351746012777	catalytic residues [active]
351746012778	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
351746012779	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351746012780	Predicted membrane protein [Function unknown]; Region: COG3308
351746012781	3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818
351746012782	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
351746012783	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
351746012784	Ligand Binding Site [chemical binding]; other site
351746012785	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
351746012786	hypothetical protein; Provisional; Region: PRK04860
351746012787	SprT homologues; Region: SprT; cl01182
351746012788	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
351746012789	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
351746012790	FAD binding pocket [chemical binding]; other site
351746012791	FAD binding motif [chemical binding]; other site
351746012792	phosphate binding motif [ion binding]; other site
351746012793	beta-alpha-beta structure motif; other site
351746012794	NAD binding pocket [chemical binding]; other site
351746012795	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
351746012796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012797	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
351746012798	putative dimerization interface [polypeptide binding]; other site
351746012799	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
351746012800	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746012801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746012802	active site
351746012803	phosphorylation site [posttranslational modification]
351746012804	intermolecular recognition site; other site
351746012805	dimerization interface [polypeptide binding]; other site
351746012806	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746012807	DNA binding residues [nucleotide binding]
351746012808	dimerization interface [polypeptide binding]; other site
351746012809	Uncharacterized conserved protein [Function unknown]; Region: COG3148
351746012810	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
351746012811	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
351746012812	recombination regulator RecX; Reviewed; Region: recX; PRK00117
351746012813	recombinase A; Provisional; Region: recA; PRK09354
351746012814	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
351746012815	hexamer interface [polypeptide binding]; other site
351746012816	Walker A motif; other site
351746012817	ATP binding site [chemical binding]; other site
351746012818	Walker B motif; other site
351746012819	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
351746012820	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
351746012821	active site
351746012822	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
351746012823	virion protein; Provisional; Region: V; PHA02564
351746012824	Ubiquitin-like proteins; Region: UBQ; cl00155
351746012825	charged pocket; other site
351746012826	hydrophobic patch; other site
351746012827	Putative phage tail protein; Region: Phage-tail_3; pfam13550
351746012828	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
351746012829	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
351746012830	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
351746012831	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
351746012832	Short C-terminal domain; Region: SHOCT; pfam09851
351746012833	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
351746012834	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
351746012835	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
351746012836	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
351746012837	oligomerization interface [polypeptide binding]; other site
351746012838	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
351746012839	Phage-related protein [Function unknown]; Region: COG4695
351746012840	Phage portal protein; Region: Phage_portal; pfam04860
351746012841	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
351746012842	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
351746012843	Phage capsid family; Region: Phage_capsid; pfam05065
351746012844	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
351746012845	Terminase small subunit; Region: Terminase_2; cl01513
351746012846	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
351746012847	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
351746012848	active site
351746012849	Protein of unknown function (DUF754); Region: DUF754; pfam05449
351746012850	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351746012851	active site
351746012852	DNA binding site [nucleotide binding]
351746012853	Int/Topo IB signature motif; other site
351746012854	VRR-NUC domain; Region: VRR_NUC; pfam08774
351746012855	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
351746012856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746012857	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746012858	Walker A motif; other site
351746012859	ATP binding site [chemical binding]; other site
351746012860	Walker B motif; other site
351746012861	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
351746012862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746012863	non-specific DNA binding site [nucleotide binding]; other site
351746012864	salt bridge; other site
351746012865	sequence-specific DNA binding site [nucleotide binding]; other site
351746012866	Predicted transcriptional regulator [Transcription]; Region: COG2932
351746012867	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746012868	Catalytic site [active]
351746012869	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
351746012870	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351746012871	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746012872	DNA binding residues [nucleotide binding]
351746012873	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
351746012874	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351746012875	dimer interface [polypeptide binding]; other site
351746012876	ssDNA binding site [nucleotide binding]; other site
351746012877	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351746012878	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
351746012879	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
351746012880	Ligand Binding Site [chemical binding]; other site
351746012881	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
351746012882	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
351746012883	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
351746012884	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351746012885	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
351746012886	dimer interface [polypeptide binding]; other site
351746012887	active site
351746012888	Int/Topo IB signature motif; other site
351746012889	Zeta toxin; Region: Zeta_toxin; pfam06414
351746012890	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
351746012891	MutS domain I; Region: MutS_I; pfam01624
351746012892	MutS domain II; Region: MutS_II; pfam05188
351746012893	MutS domain III; Region: MutS_III; pfam05192
351746012894	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
351746012895	Walker A/P-loop; other site
351746012896	ATP binding site [chemical binding]; other site
351746012897	Q-loop/lid; other site
351746012898	ABC transporter signature motif; other site
351746012899	Walker B; other site
351746012900	D-loop; other site
351746012901	H-loop/switch region; other site
351746012902	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
351746012903	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
351746012904	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
351746012905	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
351746012906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746012907	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351746012908	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746012909	DNA binding residues [nucleotide binding]
351746012910	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351746012911	Peptidase family M23; Region: Peptidase_M23; pfam01551
351746012912	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
351746012913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746012914	S-adenosylmethionine binding site [chemical binding]; other site
351746012915	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
351746012916	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
351746012917	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
351746012918	Permutation of conserved domain; other site
351746012919	active site
351746012920	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
351746012921	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
351746012922	homotrimer interaction site [polypeptide binding]; other site
351746012923	zinc binding site [ion binding]; other site
351746012924	CDP-binding sites; other site
351746012925	S-formylglutathione hydrolase; Region: PLN02442
351746012926	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
351746012927	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
351746012928	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
351746012929	substrate binding site [chemical binding]; other site
351746012930	catalytic Zn binding site [ion binding]; other site
351746012931	NAD binding site [chemical binding]; other site
351746012932	structural Zn binding site [ion binding]; other site
351746012933	dimer interface [polypeptide binding]; other site
351746012934	LysR family transcriptional regulator; Provisional; Region: PRK14997
351746012935	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746012936	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
351746012937	putative effector binding pocket; other site
351746012938	putative dimerization interface [polypeptide binding]; other site
351746012939	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
351746012940	substrate binding site; other site
351746012941	dimer interface; other site
351746012942	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
351746012943	Septum formation initiator; Region: DivIC; cl17659
351746012944	enolase; Provisional; Region: eno; PRK00077
351746012945	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
351746012946	dimer interface [polypeptide binding]; other site
351746012947	metal binding site [ion binding]; metal-binding site
351746012948	substrate binding pocket [chemical binding]; other site
351746012949	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
351746012950	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
351746012951	CTP synthetase; Validated; Region: pyrG; PRK05380
351746012952	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
351746012953	Catalytic site [active]
351746012954	active site
351746012955	UTP binding site [chemical binding]; other site
351746012956	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
351746012957	active site
351746012958	putative oxyanion hole; other site
351746012959	catalytic triad [active]
351746012960	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
351746012961	Ligand Binding Site [chemical binding]; other site
351746012962	TilS substrate binding domain; Region: TilS; pfam09179
351746012963	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
351746012964	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
351746012965	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
351746012966	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
351746012967	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
351746012968	putative active site [active]
351746012969	putative PHP Thumb interface [polypeptide binding]; other site
351746012970	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
351746012971	generic binding surface II; other site
351746012972	generic binding surface I; other site
351746012973	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
351746012974	RNA/DNA hybrid binding site [nucleotide binding]; other site
351746012975	active site
351746012976	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
351746012977	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
351746012978	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
351746012979	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
351746012980	active site
351746012981	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
351746012982	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
351746012983	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
351746012984	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
351746012985	trimer interface [polypeptide binding]; other site
351746012986	active site
351746012987	UDP-GlcNAc binding site [chemical binding]; other site
351746012988	lipid binding site [chemical binding]; lipid-binding site
351746012989	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
351746012990	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
351746012991	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746012992	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746012993	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746012994	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
351746012995	Surface antigen; Region: Bac_surface_Ag; pfam01103
351746012996	zinc metallopeptidase RseP; Provisional; Region: PRK10779
351746012997	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
351746012998	active site
351746012999	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
351746013000	protein binding site [polypeptide binding]; other site
351746013001	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
351746013002	protein binding site [polypeptide binding]; other site
351746013003	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
351746013004	putative substrate binding region [chemical binding]; other site
351746013005	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
351746013006	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
351746013007	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
351746013008	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
351746013009	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
351746013010	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
351746013011	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
351746013012	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
351746013013	catalytic residue [active]
351746013014	putative FPP diphosphate  binding site; other site
351746013015	putative FPP binding hydrophobic cleft; other site
351746013016	dimer interface [polypeptide binding]; other site
351746013017	putative IPP diphosphate binding site; other site
351746013018	ribosome recycling factor; Reviewed; Region: frr; PRK00083
351746013019	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
351746013020	hinge region; other site
351746013021	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
351746013022	putative nucleotide binding site [chemical binding]; other site
351746013023	uridine monophosphate binding site [chemical binding]; other site
351746013024	homohexameric interface [polypeptide binding]; other site
351746013025	elongation factor Ts; Provisional; Region: tsf; PRK09377
351746013026	UBA/TS-N domain; Region: UBA; pfam00627
351746013027	Elongation factor TS; Region: EF_TS; pfam00889
351746013028	Elongation factor TS; Region: EF_TS; pfam00889
351746013029	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
351746013030	rRNA interaction site [nucleotide binding]; other site
351746013031	S8 interaction site; other site
351746013032	putative laminin-1 binding site; other site
351746013033	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
351746013034	active site
351746013035	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
351746013036	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
351746013037	metal binding triad; other site
351746013038	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
351746013039	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351746013040	Zn2+ binding site [ion binding]; other site
351746013041	Mg2+ binding site [ion binding]; other site
351746013042	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
351746013043	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
351746013044	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
351746013045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746013046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746013047	homodimer interface [polypeptide binding]; other site
351746013048	catalytic residue [active]
351746013049	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
351746013050	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
351746013051	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
351746013052	addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607
351746013053	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
351746013054	ArsC family; Region: ArsC; pfam03960
351746013055	putative catalytic residues [active]
351746013056	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
351746013057	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
351746013058	putative trimer interface [polypeptide binding]; other site
351746013059	putative CoA binding site [chemical binding]; other site
351746013060	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
351746013061	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
351746013062	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351746013063	catalytic residue [active]
351746013064	Fe-S metabolism associated domain; Region: SufE; cl00951
351746013065	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
351746013066	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
351746013067	putative ATP binding site [chemical binding]; other site
351746013068	putative substrate interface [chemical binding]; other site
351746013069	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
351746013070	PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758
351746013071	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746013072	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
351746013073	Ligand binding site; other site
351746013074	DXD motif; other site
351746013075	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
351746013076	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
351746013077	metal binding site [ion binding]; metal-binding site
351746013078	dimer interface [polypeptide binding]; other site
351746013079	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
351746013080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746013081	S-adenosylmethionine binding site [chemical binding]; other site
351746013082	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351746013083	DNA-binding site [nucleotide binding]; DNA binding site
351746013084	RNA-binding motif; other site
351746013085	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
351746013086	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
351746013087	putative acyl-acceptor binding pocket; other site
351746013088	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
351746013089	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
351746013090	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
351746013091	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746013092	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746013093	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746013094	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746013095	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746013096	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
351746013097	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
351746013098	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
351746013099	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
351746013100	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
351746013101	tetramer interface [polypeptide binding]; other site
351746013102	active site
351746013103	Mg2+/Mn2+ binding site [ion binding]; other site
351746013104	Protein of unknown function DUF72; Region: DUF72; cl00777
351746013105	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
351746013106	Glycoprotease family; Region: Peptidase_M22; pfam00814
351746013107	adenylate kinase; Reviewed; Region: adk; PRK00279
351746013108	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
351746013109	AMP-binding site [chemical binding]; other site
351746013110	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
351746013111	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
351746013112	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
351746013113	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
351746013114	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746013115	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746013116	ligand binding site [chemical binding]; other site
351746013117	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746013118	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746013119	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746013120	conserved hypothetical protein; Region: QEGLA; TIGR02421
351746013121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
351746013122	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
351746013123	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
351746013124	dimer interface [polypeptide binding]; other site
351746013125	putative anticodon binding site; other site
351746013126	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
351746013127	motif 1; other site
351746013128	active site
351746013129	motif 2; other site
351746013130	motif 3; other site
351746013131	peptide chain release factor 2; Provisional; Region: PRK08787
351746013132	This domain is found in peptide chain release factors; Region: PCRF; smart00937
351746013133	RF-1 domain; Region: RF-1; pfam00472
351746013134	Response regulator receiver domain; Region: Response_reg; pfam00072
351746013135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746013136	active site
351746013137	phosphorylation site [posttranslational modification]
351746013138	intermolecular recognition site; other site
351746013139	dimerization interface [polypeptide binding]; other site
351746013140	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746013141	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746013142	metal binding site [ion binding]; metal-binding site
351746013143	active site
351746013144	I-site; other site
351746013145	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
351746013146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746013147	active site
351746013148	phosphorylation site [posttranslational modification]
351746013149	intermolecular recognition site; other site
351746013150	CheB methylesterase; Region: CheB_methylest; pfam01339
351746013151	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746013152	putative binding surface; other site
351746013153	active site
351746013154	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
351746013155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746013156	ATP binding site [chemical binding]; other site
351746013157	Mg2+ binding site [ion binding]; other site
351746013158	G-X-G motif; other site
351746013159	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
351746013160	Response regulator receiver domain; Region: Response_reg; pfam00072
351746013161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746013162	active site
351746013163	phosphorylation site [posttranslational modification]
351746013164	intermolecular recognition site; other site
351746013165	dimerization interface [polypeptide binding]; other site
351746013166	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
351746013167	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
351746013168	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
351746013169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746013170	S-adenosylmethionine binding site [chemical binding]; other site
351746013171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
351746013172	TPR motif; other site
351746013173	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351746013174	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
351746013175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746013176	dimerization interface [polypeptide binding]; other site
351746013177	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746013178	dimer interface [polypeptide binding]; other site
351746013179	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
351746013180	putative CheW interface [polypeptide binding]; other site
351746013181	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
351746013182	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
351746013183	putative metal binding site [ion binding]; other site
351746013184	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351746013185	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746013186	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
351746013187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746013188	Walker A/P-loop; other site
351746013189	ATP binding site [chemical binding]; other site
351746013190	Q-loop/lid; other site
351746013191	ABC transporter signature motif; other site
351746013192	Walker B; other site
351746013193	D-loop; other site
351746013194	H-loop/switch region; other site
351746013195	TOBE domain; Region: TOBE_2; pfam08402
351746013196	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746013197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746013198	putative PBP binding loops; other site
351746013199	dimer interface [polypeptide binding]; other site
351746013200	ABC-ATPase subunit interface; other site
351746013201	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746013202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746013203	dimer interface [polypeptide binding]; other site
351746013204	conserved gate region; other site
351746013205	ABC-ATPase subunit interface; other site
351746013206	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
351746013207	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
351746013208	tetrameric interface [polypeptide binding]; other site
351746013209	NAD binding site [chemical binding]; other site
351746013210	catalytic residues [active]
351746013211	substrate binding site [chemical binding]; other site
351746013212	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
351746013213	HicB family; Region: HicB; pfam05534
351746013214	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
351746013215	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
351746013216	active site
351746013217	FMN binding site [chemical binding]; other site
351746013218	substrate binding site [chemical binding]; other site
351746013219	homotetramer interface [polypeptide binding]; other site
351746013220	catalytic residue [active]
351746013221	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
351746013222	DHH family; Region: DHH; pfam01368
351746013223	DHHA1 domain; Region: DHHA1; pfam02272
351746013224	YaeQ protein; Region: YaeQ; pfam07152
351746013225	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
351746013226	CoA-transferase family III; Region: CoA_transf_3; pfam02515
351746013227	conserved hypothetical protein; Region: TIGR02285
351746013228	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
351746013229	Response regulator receiver domain; Region: Response_reg; pfam00072
351746013230	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
351746013231	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
351746013232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746013233	catalytic residue [active]
351746013234	homoserine dehydrogenase; Provisional; Region: PRK06349
351746013235	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
351746013236	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
351746013237	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
351746013238	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
351746013239	dimerization domain [polypeptide binding]; other site
351746013240	dimer interface [polypeptide binding]; other site
351746013241	catalytic residues [active]
351746013242	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
351746013243	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
351746013244	active site
351746013245	Int/Topo IB signature motif; other site
351746013246	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
351746013247	TrkA-N domain; Region: TrkA_N; pfam02254
351746013248	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
351746013249	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
351746013250	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
351746013251	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
351746013252	RimM N-terminal domain; Region: RimM; pfam01782
351746013253	PRC-barrel domain; Region: PRC; pfam05239
351746013254	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
351746013255	signal recognition particle protein; Provisional; Region: PRK10867
351746013256	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
351746013257	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
351746013258	P loop; other site
351746013259	GTP binding site [chemical binding]; other site
351746013260	Signal peptide binding domain; Region: SRP_SPB; pfam02978
351746013261	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
351746013262	FOG: CBS domain [General function prediction only]; Region: COG0517
351746013263	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
351746013264	Transporter associated domain; Region: CorC_HlyC; smart01091
351746013265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013266	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746013267	putative substrate translocation pore; other site
351746013268	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
351746013269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746013270	ATP-grasp domain; Region: ATP-grasp; pfam02222
351746013271	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
351746013272	Predicted Fe-S protein [General function prediction only]; Region: COG3313
351746013273	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
351746013274	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
351746013275	trimer interface [polypeptide binding]; other site
351746013276	putative metal binding site [ion binding]; other site
351746013277	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
351746013278	putative active site [active]
351746013279	putative CoA binding site [chemical binding]; other site
351746013280	nudix motif; other site
351746013281	metal binding site [ion binding]; metal-binding site
351746013282	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
351746013283	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
351746013284	nudix motif; other site
351746013285	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
351746013286	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
351746013287	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
351746013288	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
351746013289	haemagglutination activity domain; Region: Haemagg_act; pfam05860
351746013290	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
351746013291	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
351746013292	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
351746013293	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
351746013294	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
351746013295	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
351746013296	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
351746013297	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746013298	N-terminal plug; other site
351746013299	ligand-binding site [chemical binding]; other site
351746013300	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
351746013301	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
351746013302	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
351746013303	Trp docking motif [polypeptide binding]; other site
351746013304	putative active site [active]
351746013305	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
351746013306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746013307	Walker A motif; other site
351746013308	ATP binding site [chemical binding]; other site
351746013309	Walker B motif; other site
351746013310	arginine finger; other site
351746013311	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
351746013312	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
351746013313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746013314	active site
351746013315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746013316	S-adenosylmethionine binding site [chemical binding]; other site
351746013317	Methyltransferase domain; Region: Methyltransf_31; pfam13847
351746013318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746013319	S-adenosylmethionine binding site [chemical binding]; other site
351746013320	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
351746013321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746013322	active site
351746013323	phosphorylation site [posttranslational modification]
351746013324	intermolecular recognition site; other site
351746013325	dimerization interface [polypeptide binding]; other site
351746013326	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746013327	DNA binding site [nucleotide binding]
351746013328	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
351746013329	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746013330	dimerization interface [polypeptide binding]; other site
351746013331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746013332	dimer interface [polypeptide binding]; other site
351746013333	phosphorylation site [posttranslational modification]
351746013334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746013335	ATP binding site [chemical binding]; other site
351746013336	Mg2+ binding site [ion binding]; other site
351746013337	G-X-G motif; other site
351746013338	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
351746013339	active site
351746013340	hydrophilic channel; other site
351746013341	dimerization interface [polypeptide binding]; other site
351746013342	catalytic residues [active]
351746013343	active site lid [active]
351746013344	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
351746013345	Recombination protein O N terminal; Region: RecO_N; pfam11967
351746013346	Recombination protein O C terminal; Region: RecO_C; pfam02565
351746013347	GTPase Era; Reviewed; Region: era; PRK00089
351746013348	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
351746013349	G1 box; other site
351746013350	GTP/Mg2+ binding site [chemical binding]; other site
351746013351	Switch I region; other site
351746013352	G2 box; other site
351746013353	Switch II region; other site
351746013354	G3 box; other site
351746013355	G4 box; other site
351746013356	G5 box; other site
351746013357	KH domain; Region: KH_2; pfam07650
351746013358	ribonuclease III; Reviewed; Region: rnc; PRK00102
351746013359	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
351746013360	dimerization interface [polypeptide binding]; other site
351746013361	active site
351746013362	metal binding site [ion binding]; metal-binding site
351746013363	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
351746013364	dsRNA binding site [nucleotide binding]; other site
351746013365	signal peptidase I; Provisional; Region: PRK10861
351746013366	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
351746013367	Catalytic site [active]
351746013368	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
351746013369	GTP-binding protein LepA; Provisional; Region: PRK05433
351746013370	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
351746013371	G1 box; other site
351746013372	putative GEF interaction site [polypeptide binding]; other site
351746013373	GTP/Mg2+ binding site [chemical binding]; other site
351746013374	Switch I region; other site
351746013375	G2 box; other site
351746013376	G3 box; other site
351746013377	Switch II region; other site
351746013378	G4 box; other site
351746013379	G5 box; other site
351746013380	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
351746013381	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
351746013382	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
351746013383	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
351746013384	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
351746013385	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351746013386	protein binding site [polypeptide binding]; other site
351746013387	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351746013388	protein binding site [polypeptide binding]; other site
351746013389	anti-sigma E factor; Provisional; Region: rseB; PRK09455
351746013390	MucB/RseB family; Region: MucB_RseB; pfam03888
351746013391	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
351746013392	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
351746013393	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
351746013394	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
351746013395	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746013396	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746013397	DNA binding residues [nucleotide binding]
351746013398	L-aspartate oxidase; Provisional; Region: PRK09077
351746013399	L-aspartate oxidase; Provisional; Region: PRK06175
351746013400	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
351746013401	Uncharacterized conserved protein [Function unknown]; Region: COG2938
351746013402	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
351746013403	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
351746013404	HDOD domain; Region: HDOD; pfam08668
351746013405	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
351746013406	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746013407	dimerization interface [polypeptide binding]; other site
351746013408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746013409	dimer interface [polypeptide binding]; other site
351746013410	phosphorylation site [posttranslational modification]
351746013411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746013412	ATP binding site [chemical binding]; other site
351746013413	Mg2+ binding site [ion binding]; other site
351746013414	G-X-G motif; other site
351746013415	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
351746013416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746013417	active site
351746013418	phosphorylation site [posttranslational modification]
351746013419	intermolecular recognition site; other site
351746013420	dimerization interface [polypeptide binding]; other site
351746013421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746013422	DNA binding site [nucleotide binding]
351746013423	outer membrane porin, OprD family; Region: OprD; pfam03573
351746013424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
351746013425	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
351746013426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
351746013427	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
351746013428	Putative ammonia monooxygenase; Region: AmoA; pfam05145
351746013429	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
351746013430	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
351746013431	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
351746013432	putative active site [active]
351746013433	putative metal binding site [ion binding]; other site
351746013434	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
351746013435	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
351746013436	ligand binding site [chemical binding]; other site
351746013437	active site
351746013438	UGI interface [polypeptide binding]; other site
351746013439	catalytic site [active]
351746013440	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
351746013441	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
351746013442	substrate binding site [chemical binding]; other site
351746013443	oxyanion hole (OAH) forming residues; other site
351746013444	trimer interface [polypeptide binding]; other site
351746013445	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
351746013446	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746013447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746013448	metal binding site [ion binding]; metal-binding site
351746013449	active site
351746013450	I-site; other site
351746013451	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
351746013452	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
351746013453	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351746013454	RNA binding surface [nucleotide binding]; other site
351746013455	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
351746013456	active site
351746013457	uracil binding [chemical binding]; other site
351746013458	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746013459	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
351746013460	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
351746013461	Sulfate transporter family; Region: Sulfate_transp; pfam00916
351746013462	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
351746013463	Methyltransferase domain; Region: Methyltransf_31; pfam13847
351746013464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746013465	S-adenosylmethionine binding site [chemical binding]; other site
351746013466	Repair protein; Region: Repair_PSII; cl01535
351746013467	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
351746013468	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
351746013469	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
351746013470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746013471	dimer interface [polypeptide binding]; other site
351746013472	phosphorylation site [posttranslational modification]
351746013473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746013474	ATP binding site [chemical binding]; other site
351746013475	Mg2+ binding site [ion binding]; other site
351746013476	G-X-G motif; other site
351746013477	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746013478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746013479	active site
351746013480	phosphorylation site [posttranslational modification]
351746013481	intermolecular recognition site; other site
351746013482	dimerization interface [polypeptide binding]; other site
351746013483	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746013484	Walker A motif; other site
351746013485	ATP binding site [chemical binding]; other site
351746013486	Walker B motif; other site
351746013487	arginine finger; other site
351746013488	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746013489	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
351746013490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013491	putative substrate translocation pore; other site
351746013492	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
351746013493	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
351746013494	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
351746013495	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746013496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746013497	hypothetical protein; Provisional; Region: PRK07524
351746013498	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746013499	PYR/PP interface [polypeptide binding]; other site
351746013500	dimer interface [polypeptide binding]; other site
351746013501	TPP binding site [chemical binding]; other site
351746013502	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746013503	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
351746013504	TPP-binding site [chemical binding]; other site
351746013505	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746013506	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746013507	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746013508	substrate binding pocket [chemical binding]; other site
351746013509	dimerization interface [polypeptide binding]; other site
351746013510	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
351746013511	NADH(P)-binding; Region: NAD_binding_10; pfam13460
351746013512	NAD binding site [chemical binding]; other site
351746013513	substrate binding site [chemical binding]; other site
351746013514	putative active site [active]
351746013515	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746013516	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746013517	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746013518	putative effector binding pocket; other site
351746013519	dimerization interface [polypeptide binding]; other site
351746013520	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
351746013521	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
351746013522	tetramer interface [polypeptide binding]; other site
351746013523	active site
351746013524	Mg2+/Mn2+ binding site [ion binding]; other site
351746013525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013526	putative substrate translocation pore; other site
351746013527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013528	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
351746013529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746013530	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
351746013531	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746013532	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746013533	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746013534	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
351746013535	Protein export membrane protein; Region: SecD_SecF; cl14618
351746013536	Protein export membrane protein; Region: SecD_SecF; cl14618
351746013537	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
351746013538	outer membrane porin, OprD family; Region: OprD; pfam03573
351746013539	Predicted membrane protein [Function unknown]; Region: COG4539
351746013540	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
351746013541	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
351746013542	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
351746013543	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
351746013544	tetramer interface [polypeptide binding]; other site
351746013545	active site
351746013546	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
351746013547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013548	putative substrate translocation pore; other site
351746013549	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
351746013550	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746013551	dimer interface [polypeptide binding]; other site
351746013552	active site
351746013553	benzoate transport; Region: 2A0115; TIGR00895
351746013554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013555	putative substrate translocation pore; other site
351746013556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013557	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
351746013558	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351746013559	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746013560	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
351746013561	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
351746013562	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
351746013563	Cache domain; Region: Cache_1; pfam02743
351746013564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746013565	dimerization interface [polypeptide binding]; other site
351746013566	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746013567	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746013568	dimer interface [polypeptide binding]; other site
351746013569	putative CheW interface [polypeptide binding]; other site
351746013570	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746013571	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
351746013572	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
351746013573	Predicted deacetylase [General function prediction only]; Region: COG3233
351746013574	putative active site [active]
351746013575	putative Zn binding site [ion binding]; other site
351746013576	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
351746013577	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
351746013578	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
351746013579	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
351746013580	putative active site [active]
351746013581	putative substrate binding site [chemical binding]; other site
351746013582	putative cosubstrate binding site; other site
351746013583	catalytic site [active]
351746013584	exonuclease I; Provisional; Region: sbcB; PRK11779
351746013585	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
351746013586	active site
351746013587	catalytic site [active]
351746013588	substrate binding site [chemical binding]; other site
351746013589	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
351746013590	PilZ domain; Region: PilZ; pfam07238
351746013591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
351746013592	pyruvate kinase; Provisional; Region: PRK05826
351746013593	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
351746013594	domain interfaces; other site
351746013595	active site
351746013596	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
351746013597	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
351746013598	ring oligomerisation interface [polypeptide binding]; other site
351746013599	ATP/Mg binding site [chemical binding]; other site
351746013600	stacking interactions; other site
351746013601	hinge regions; other site
351746013602	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
351746013603	oligomerisation interface [polypeptide binding]; other site
351746013604	mobile loop; other site
351746013605	roof hairpin; other site
351746013606	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
351746013607	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
351746013608	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
351746013609	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
351746013610	Protein of unknown function, DUF481; Region: DUF481; pfam04338
351746013611	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
351746013612	DNA binding site [nucleotide binding]
351746013613	active site
351746013614	muropeptide transporter; Validated; Region: ampG; cl17669
351746013615	muropeptide transporter; Validated; Region: ampG; cl17669
351746013616	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
351746013617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013618	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
351746013619	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746013620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
351746013621	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
351746013622	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
351746013623	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
351746013624	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
351746013625	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746013626	dimerization interface [polypeptide binding]; other site
351746013627	PAS domain; Region: PAS; smart00091
351746013628	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
351746013629	putative active site [active]
351746013630	heme pocket [chemical binding]; other site
351746013631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746013632	dimer interface [polypeptide binding]; other site
351746013633	phosphorylation site [posttranslational modification]
351746013634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746013635	ATP binding site [chemical binding]; other site
351746013636	Mg2+ binding site [ion binding]; other site
351746013637	G-X-G motif; other site
351746013638	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
351746013639	hypothetical protein; Provisional; Region: PRK08999
351746013640	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
351746013641	active site
351746013642	8-oxo-dGMP binding site [chemical binding]; other site
351746013643	nudix motif; other site
351746013644	metal binding site [ion binding]; metal-binding site
351746013645	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
351746013646	thiamine phosphate binding site [chemical binding]; other site
351746013647	active site
351746013648	pyrophosphate binding site [ion binding]; other site
351746013649	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
351746013650	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
351746013651	putative C-terminal domain interface [polypeptide binding]; other site
351746013652	putative GSH binding site (G-site) [chemical binding]; other site
351746013653	putative dimer interface [polypeptide binding]; other site
351746013654	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
351746013655	putative substrate binding pocket (H-site) [chemical binding]; other site
351746013656	putative N-terminal domain interface [polypeptide binding]; other site
351746013657	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
351746013658	heterotetramer interface [polypeptide binding]; other site
351746013659	active site pocket [active]
351746013660	cleavage site
351746013661	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
351746013662	DEAD/DEAH box helicase; Region: DEAD; pfam00270
351746013663	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
351746013664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
351746013665	nucleotide binding region [chemical binding]; other site
351746013666	ATP-binding site [chemical binding]; other site
351746013667	SEC-C motif; Region: SEC-C; pfam02810
351746013668	Protein of unknown function (DUF721); Region: DUF721; pfam05258
351746013669	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
351746013670	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
351746013671	cell division protein FtsZ; Validated; Region: PRK09330
351746013672	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
351746013673	nucleotide binding site [chemical binding]; other site
351746013674	SulA interaction site; other site
351746013675	cell division protein FtsA; Region: ftsA; TIGR01174
351746013676	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
351746013677	nucleotide binding site [chemical binding]; other site
351746013678	Cell division protein FtsA; Region: FtsA; pfam14450
351746013679	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
351746013680	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
351746013681	Cell division protein FtsQ; Region: FtsQ; pfam03799
351746013682	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
351746013683	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
351746013684	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351746013685	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
351746013686	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351746013687	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351746013688	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351746013689	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
351746013690	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
351746013691	active site
351746013692	homodimer interface [polypeptide binding]; other site
351746013693	cell division protein FtsW; Region: ftsW; TIGR02614
351746013694	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
351746013695	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351746013696	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
351746013697	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
351746013698	Mg++ binding site [ion binding]; other site
351746013699	putative catalytic motif [active]
351746013700	putative substrate binding site [chemical binding]; other site
351746013701	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351746013702	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
351746013703	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351746013704	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351746013705	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
351746013706	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351746013707	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351746013708	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351746013709	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
351746013710	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
351746013711	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351746013712	Cell division protein FtsL; Region: FtsL; pfam04999
351746013713	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
351746013714	MraW methylase family; Region: Methyltransf_5; cl17771
351746013715	cell division protein MraZ; Reviewed; Region: PRK00326
351746013716	MraZ protein; Region: MraZ; pfam02381
351746013717	MraZ protein; Region: MraZ; pfam02381
351746013718	Predicted methyltransferases [General function prediction only]; Region: COG0313
351746013719	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
351746013720	putative SAM binding site [chemical binding]; other site
351746013721	putative homodimer interface [polypeptide binding]; other site
351746013722	LppC putative lipoprotein; Region: LppC; pfam04348
351746013723	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
351746013724	putative ligand binding site [chemical binding]; other site
351746013725	hypothetical protein; Reviewed; Region: PRK12497
351746013726	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
351746013727	dimer interface [polypeptide binding]; other site
351746013728	active site
351746013729	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
351746013730	BON domain; Region: BON; pfam04972
351746013731	BON domain; Region: BON; pfam04972
351746013732	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
351746013733	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
351746013734	stringent starvation protein A; Provisional; Region: sspA; PRK09481
351746013735	C-terminal domain interface [polypeptide binding]; other site
351746013736	putative GSH binding site (G-site) [chemical binding]; other site
351746013737	dimer interface [polypeptide binding]; other site
351746013738	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
351746013739	dimer interface [polypeptide binding]; other site
351746013740	N-terminal domain interface [polypeptide binding]; other site
351746013741	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
351746013742	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
351746013743	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
351746013744	Qi binding site; other site
351746013745	intrachain domain interface; other site
351746013746	interchain domain interface [polypeptide binding]; other site
351746013747	heme bH binding site [chemical binding]; other site
351746013748	heme bL binding site [chemical binding]; other site
351746013749	Qo binding site; other site
351746013750	interchain domain interface [polypeptide binding]; other site
351746013751	intrachain domain interface; other site
351746013752	Qi binding site; other site
351746013753	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
351746013754	Qo binding site; other site
351746013755	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
351746013756	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
351746013757	[2Fe-2S] cluster binding site [ion binding]; other site
351746013758	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
351746013759	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
351746013760	23S rRNA interface [nucleotide binding]; other site
351746013761	L3 interface [polypeptide binding]; other site
351746013762	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746013763	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746013764	active site
351746013765	catalytic tetrad [active]
351746013766	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746013767	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
351746013768	conserved cys residue [active]
351746013769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746013770	Predicted ATPase [General function prediction only]; Region: COG1485
351746013771	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
351746013772	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
351746013773	active site
351746013774	HIGH motif; other site
351746013775	dimer interface [polypeptide binding]; other site
351746013776	KMSKS motif; other site
351746013777	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
351746013778	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
351746013779	methionine gamma-lyase; Provisional; Region: PRK07503
351746013780	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351746013781	homodimer interface [polypeptide binding]; other site
351746013782	substrate-cofactor binding pocket; other site
351746013783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746013784	catalytic residue [active]
351746013785	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746013786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746013787	putative DNA binding site [nucleotide binding]; other site
351746013788	putative Zn2+ binding site [ion binding]; other site
351746013789	AsnC family; Region: AsnC_trans_reg; pfam01037
351746013790	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
351746013791	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
351746013792	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
351746013793	CysD dimerization site [polypeptide binding]; other site
351746013794	G1 box; other site
351746013795	putative GEF interaction site [polypeptide binding]; other site
351746013796	GTP/Mg2+ binding site [chemical binding]; other site
351746013797	Switch I region; other site
351746013798	G2 box; other site
351746013799	G3 box; other site
351746013800	Switch II region; other site
351746013801	G4 box; other site
351746013802	G5 box; other site
351746013803	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
351746013804	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
351746013805	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
351746013806	ligand-binding site [chemical binding]; other site
351746013807	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
351746013808	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
351746013809	Active Sites [active]
351746013810	Uncharacterized conserved protein [Function unknown]; Region: COG0327
351746013811	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
351746013812	serine endoprotease; Provisional; Region: PRK10898
351746013813	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
351746013814	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351746013815	protein binding site [polypeptide binding]; other site
351746013816	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
351746013817	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746013818	Walker A/P-loop; other site
351746013819	ATP binding site [chemical binding]; other site
351746013820	Q-loop/lid; other site
351746013821	ABC transporter signature motif; other site
351746013822	Walker B; other site
351746013823	D-loop; other site
351746013824	H-loop/switch region; other site
351746013825	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746013826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746013827	dimer interface [polypeptide binding]; other site
351746013828	conserved gate region; other site
351746013829	putative PBP binding loops; other site
351746013830	ABC-ATPase subunit interface; other site
351746013831	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
351746013832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746013833	conserved gate region; other site
351746013834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746013835	dimer interface [polypeptide binding]; other site
351746013836	ABC-ATPase subunit interface; other site
351746013837	putative PBP binding loops; other site
351746013838	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746013839	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
351746013840	substrate binding pocket [chemical binding]; other site
351746013841	membrane-bound complex binding site; other site
351746013842	hinge residues; other site
351746013843	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
351746013844	putative hydrolase; Provisional; Region: PRK11460
351746013845	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
351746013846	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
351746013847	ATP binding site [chemical binding]; other site
351746013848	Mg++ binding site [ion binding]; other site
351746013849	motif III; other site
351746013850	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746013851	nucleotide binding region [chemical binding]; other site
351746013852	ATP-binding site [chemical binding]; other site
351746013853	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
351746013854	MoaD interaction [polypeptide binding]; other site
351746013855	active site residues [active]
351746013856	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
351746013857	MoaE interaction surface [polypeptide binding]; other site
351746013858	MoeB interaction surface [polypeptide binding]; other site
351746013859	thiocarboxylated glycine; other site
351746013860	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
351746013861	trimer interface [polypeptide binding]; other site
351746013862	dimer interface [polypeptide binding]; other site
351746013863	putative active site [active]
351746013864	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
351746013865	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
351746013866	putative active site [active]
351746013867	PhoH-like protein; Region: PhoH; pfam02562
351746013868	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
351746013869	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
351746013870	NodB motif; other site
351746013871	active site
351746013872	catalytic site [active]
351746013873	metal binding site [ion binding]; metal-binding site
351746013874	hypothetical protein; Validated; Region: PRK02101
351746013875	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
351746013876	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
351746013877	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
351746013878	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
351746013879	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746013880	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
351746013881	PilZ domain; Region: PilZ; pfam07238
351746013882	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746013883	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
351746013884	Sel1-like repeats; Region: SEL1; smart00671
351746013885	Right handed beta helix region; Region: Beta_helix; pfam13229
351746013886	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
351746013887	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244
351746013888	active site
351746013889	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
351746013890	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
351746013891	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
351746013892	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
351746013893	Substrate binding site; other site
351746013894	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
351746013895	short chain dehydrogenase; Provisional; Region: PRK05693
351746013896	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
351746013897	NADP binding site [chemical binding]; other site
351746013898	active site
351746013899	steroid binding site; other site
351746013900	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
351746013901	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
351746013902	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746013903	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746013904	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
351746013905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746013906	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746013907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746013908	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
351746013909	putative substrate binding pocket [chemical binding]; other site
351746013910	putative dimerization interface [polypeptide binding]; other site
351746013911	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
351746013912	Ligand Binding Site [chemical binding]; other site
351746013913	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
351746013914	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746013915	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746013916	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
351746013917	Fusaric acid resistance protein family; Region: FUSC; pfam04632
351746013918	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
351746013919	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
351746013920	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746013921	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746013922	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
351746013923	putative effector binding pocket; other site
351746013924	dimerization interface [polypeptide binding]; other site
351746013925	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
351746013926	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
351746013927	dimerization interface [polypeptide binding]; other site
351746013928	ligand binding site [chemical binding]; other site
351746013929	NADP binding site [chemical binding]; other site
351746013930	catalytic site [active]
351746013931	EamA-like transporter family; Region: EamA; pfam00892
351746013932	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746013933	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746013934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746013935	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
351746013936	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746013937	N-terminal plug; other site
351746013938	ligand-binding site [chemical binding]; other site
351746013939	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
351746013940	FecR protein; Region: FecR; pfam04773
351746013941	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
351746013942	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746013943	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746013944	DNA binding residues [nucleotide binding]
351746013945	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
351746013946	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
351746013947	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
351746013948	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
351746013949	Protein of unknown function (DUF3649); Region: DUF3649; pfam12365
351746013950	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
351746013951	30S subunit binding site; other site
351746013952	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
351746013953	Predicted membrane protein [Function unknown]; Region: COG3223
351746013954	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746013955	YebG protein; Region: YebG; pfam07130
351746013956	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
351746013957	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
351746013958	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
351746013959	NAD binding site [chemical binding]; other site
351746013960	Phe binding site; other site
351746013961	Uncharacterized conserved protein [Function unknown]; Region: COG2912
351746013962	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
351746013963	maleylacetoacetate isomerase; Region: maiA; TIGR01262
351746013964	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
351746013965	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
351746013966	dimer interface [polypeptide binding]; other site
351746013967	N-terminal domain interface [polypeptide binding]; other site
351746013968	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
351746013969	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
351746013970	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
351746013971	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
351746013972	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
351746013973	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351746013974	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351746013975	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746013976	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746013977	LrgB-like family; Region: LrgB; pfam04172
351746013978	LrgA family; Region: LrgA; pfam03788
351746013979	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746013980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746013981	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
351746013982	putative dimerization interface [polypeptide binding]; other site
351746013983	flavodoxin; Provisional; Region: PRK05723
351746013984	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746013985	PAS domain; Region: PAS_9; pfam13426
351746013986	putative active site [active]
351746013987	heme pocket [chemical binding]; other site
351746013988	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
351746013989	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
351746013990	DNA binding residues [nucleotide binding]
351746013991	B12 binding domain; Region: B12-binding_2; pfam02607
351746013992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
351746013993	dihydromonapterin reductase; Provisional; Region: PRK06483
351746013994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746013995	NAD(P) binding site [chemical binding]; other site
351746013996	active site
351746013997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
351746013998	HopJ type III effector protein; Region: HopJ; pfam08888
351746013999	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
351746014000	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746014001	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
351746014002	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
351746014003	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
351746014004	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
351746014005	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
351746014006	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
351746014007	dimer interface [polypeptide binding]; other site
351746014008	active site
351746014009	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
351746014010	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
351746014011	FAD binding site [chemical binding]; other site
351746014012	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
351746014013	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
351746014014	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
351746014015	P-loop, Walker A motif; other site
351746014016	Base recognition motif; other site
351746014017	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
351746014018	Protein of unknown function (DUF466); Region: DUF466; pfam04328
351746014019	carbon starvation protein A; Provisional; Region: PRK15015
351746014020	Carbon starvation protein CstA; Region: CstA; pfam02554
351746014021	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
351746014022	xanthine permease; Region: pbuX; TIGR03173
351746014023	DNA repair protein RadA; Provisional; Region: PRK11823
351746014024	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746014025	Walker A motif; other site
351746014026	ATP binding site [chemical binding]; other site
351746014027	Walker B motif; other site
351746014028	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
351746014029	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
351746014030	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
351746014031	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
351746014032	ferredoxin-NADP reductase; Provisional; Region: PRK10926
351746014033	FAD binding pocket [chemical binding]; other site
351746014034	FAD binding motif [chemical binding]; other site
351746014035	phosphate binding motif [ion binding]; other site
351746014036	beta-alpha-beta structure motif; other site
351746014037	NAD binding pocket [chemical binding]; other site
351746014038	Autoinducer binding domain; Region: Autoind_bind; pfam03472
351746014039	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746014040	DNA binding residues [nucleotide binding]
351746014041	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
351746014042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746014043	S-adenosylmethionine binding site [chemical binding]; other site
351746014044	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
351746014045	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
351746014046	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
351746014047	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
351746014048	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
351746014049	H+ Antiporter protein; Region: 2A0121; TIGR00900
351746014050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746014051	putative substrate translocation pore; other site
351746014052	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
351746014053	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
351746014054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746014055	S-adenosylmethionine binding site [chemical binding]; other site
351746014056	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
351746014057	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
351746014058	heterodimer interface [polypeptide binding]; other site
351746014059	active site
351746014060	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
351746014061	heterodimer interface [polypeptide binding]; other site
351746014062	multimer interface [polypeptide binding]; other site
351746014063	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
351746014064	active site
351746014065	Predicted metalloprotease [General function prediction only]; Region: COG2321
351746014066	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
351746014067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746014068	dimerization interface [polypeptide binding]; other site
351746014069	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746014070	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746014071	dimer interface [polypeptide binding]; other site
351746014072	putative CheW interface [polypeptide binding]; other site
351746014073	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
351746014074	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
351746014075	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746014076	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746014077	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746014078	dimerization interface [polypeptide binding]; other site
351746014079	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
351746014080	Uncharacterized conserved protein [Function unknown]; Region: COG1359
351746014081	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746014082	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746014083	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
351746014084	putative dimerization interface [polypeptide binding]; other site
351746014085	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
351746014086	putative metal binding site [ion binding]; other site
351746014087	putative homodimer interface [polypeptide binding]; other site
351746014088	putative homotetramer interface [polypeptide binding]; other site
351746014089	putative homodimer-homodimer interface [polypeptide binding]; other site
351746014090	putative allosteric switch controlling residues; other site
351746014091	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
351746014092	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
351746014093	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
351746014094	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
351746014095	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
351746014096	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
351746014097	tetrameric interface [polypeptide binding]; other site
351746014098	NAD binding site [chemical binding]; other site
351746014099	catalytic residues [active]
351746014100	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746014101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746014102	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746014103	dimerization interface [polypeptide binding]; other site
351746014104	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
351746014105	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746014106	ligand binding site [chemical binding]; other site
351746014107	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
351746014108	HAMP domain; Region: HAMP; pfam00672
351746014109	dimerization interface [polypeptide binding]; other site
351746014110	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746014111	metal binding site [ion binding]; metal-binding site
351746014112	active site
351746014113	I-site; other site
351746014114	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
351746014115	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
351746014116	AAA domain; Region: AAA_30; pfam13604
351746014117	Family description; Region: UvrD_C_2; pfam13538
351746014118	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
351746014119	Family description; Region: UvrD_C_2; pfam13538
351746014120	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
351746014121	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
351746014122	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
351746014123	TMAO/DMSO reductase; Reviewed; Region: PRK05363
351746014124	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
351746014125	Moco binding site; other site
351746014126	metal coordination site [ion binding]; other site
351746014127	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
351746014128	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
351746014129	ketol-acid reductoisomerase; Provisional; Region: PRK05479
351746014130	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
351746014131	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
351746014132	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
351746014133	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
351746014134	putative valine binding site [chemical binding]; other site
351746014135	dimer interface [polypeptide binding]; other site
351746014136	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
351746014137	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
351746014138	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351746014139	PYR/PP interface [polypeptide binding]; other site
351746014140	dimer interface [polypeptide binding]; other site
351746014141	TPP binding site [chemical binding]; other site
351746014142	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351746014143	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
351746014144	TPP-binding site [chemical binding]; other site
351746014145	dimer interface [polypeptide binding]; other site
351746014146	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
351746014147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351746014148	TPR motif; other site
351746014149	binding surface
351746014150	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
351746014151	Transglycosylase; Region: Transgly; pfam00912
351746014152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
351746014153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
351746014154	AAA domain; Region: AAA_33; pfam13671
351746014155	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
351746014156	ATP-binding site [chemical binding]; other site
351746014157	Gluconate-6-phosphate binding site [chemical binding]; other site
351746014158	TfoX C-terminal domain; Region: TfoX_C; pfam04994
351746014159	Protein of unknown function, DUF399; Region: DUF399; cl01139
351746014160	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
351746014161	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
351746014162	Walker A/P-loop; other site
351746014163	ATP binding site [chemical binding]; other site
351746014164	Q-loop/lid; other site
351746014165	ABC transporter signature motif; other site
351746014166	Walker B; other site
351746014167	D-loop; other site
351746014168	H-loop/switch region; other site
351746014169	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
351746014170	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351746014171	ABC-ATPase subunit  interface; other site
351746014172	dimer interface [polypeptide binding]; other site
351746014173	putative PBP binding regions; other site
351746014174	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
351746014175	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
351746014176	intersubunit interface [polypeptide binding]; other site
351746014177	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
351746014178	iron-sulfur cluster [ion binding]; other site
351746014179	[2Fe-2S] cluster binding site [ion binding]; other site
351746014180	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
351746014181	hypothetical protein; Provisional; Region: PRK08960
351746014182	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746014183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746014184	homodimer interface [polypeptide binding]; other site
351746014185	catalytic residue [active]
351746014186	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
351746014187	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
351746014188	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
351746014189	active site
351746014190	nucleotide binding site [chemical binding]; other site
351746014191	HIGH motif; other site
351746014192	KMSKS motif; other site
351746014193	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
351746014194	Na binding site [ion binding]; other site
351746014195	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351746014196	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746014197	putative active site [active]
351746014198	heme pocket [chemical binding]; other site
351746014199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746014200	dimer interface [polypeptide binding]; other site
351746014201	phosphorylation site [posttranslational modification]
351746014202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746014203	ATP binding site [chemical binding]; other site
351746014204	Mg2+ binding site [ion binding]; other site
351746014205	G-X-G motif; other site
351746014206	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
351746014207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746014208	active site
351746014209	phosphorylation site [posttranslational modification]
351746014210	intermolecular recognition site; other site
351746014211	dimerization interface [polypeptide binding]; other site
351746014212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746014213	Walker A motif; other site
351746014214	ATP binding site [chemical binding]; other site
351746014215	Walker B motif; other site
351746014216	arginine finger; other site
351746014217	poly(A) polymerase; Region: pcnB; TIGR01942
351746014218	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
351746014219	active site
351746014220	NTP binding site [chemical binding]; other site
351746014221	metal binding triad [ion binding]; metal-binding site
351746014222	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
351746014223	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
351746014224	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
351746014225	catalytic center binding site [active]
351746014226	ATP binding site [chemical binding]; other site
351746014227	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
351746014228	oligomerization interface [polypeptide binding]; other site
351746014229	active site
351746014230	metal binding site [ion binding]; metal-binding site
351746014231	Pantoate-beta-alanine ligase; Region: PanC; cd00560
351746014232	pantoate--beta-alanine ligase; Region: panC; TIGR00018
351746014233	active site
351746014234	ATP-binding site [chemical binding]; other site
351746014235	pantoate-binding site; other site
351746014236	HXXH motif; other site
351746014237	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
351746014238	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
351746014239	active site
351746014240	dimer interface [polypeptide binding]; other site
351746014241	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
351746014242	dimer interface [polypeptide binding]; other site
351746014243	active site
351746014244	acetyl-CoA synthetase; Provisional; Region: PRK00174
351746014245	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
351746014246	active site
351746014247	CoA binding site [chemical binding]; other site
351746014248	acyl-activating enzyme (AAE) consensus motif; other site
351746014249	AMP binding site [chemical binding]; other site
351746014250	acetate binding site [chemical binding]; other site
351746014251	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
351746014252	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
351746014253	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
351746014254	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
351746014255	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
351746014256	ligand binding site [chemical binding]; other site
351746014257	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
351746014258	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351746014259	active site
351746014260	metal binding site [ion binding]; metal-binding site
351746014261	Uncharacterized conserved protein [Function unknown]; Region: COG1359
351746014262	BON domain; Region: BON; pfam04972
351746014263	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
351746014264	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
351746014265	RNase E interface [polypeptide binding]; other site
351746014266	trimer interface [polypeptide binding]; other site
351746014267	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
351746014268	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
351746014269	RNase E interface [polypeptide binding]; other site
351746014270	trimer interface [polypeptide binding]; other site
351746014271	active site
351746014272	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
351746014273	putative nucleic acid binding region [nucleotide binding]; other site
351746014274	G-X-X-G motif; other site
351746014275	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
351746014276	RNA binding site [nucleotide binding]; other site
351746014277	domain interface; other site
351746014278	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
351746014279	16S/18S rRNA binding site [nucleotide binding]; other site
351746014280	S13e-L30e interaction site [polypeptide binding]; other site
351746014281	25S rRNA binding site [nucleotide binding]; other site
351746014282	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
351746014283	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
351746014284	RNA binding site [nucleotide binding]; other site
351746014285	active site
351746014286	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
351746014287	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
351746014288	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
351746014289	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
351746014290	translation initiation factor IF-2; Region: IF-2; TIGR00487
351746014291	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
351746014292	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
351746014293	G1 box; other site
351746014294	putative GEF interaction site [polypeptide binding]; other site
351746014295	GTP/Mg2+ binding site [chemical binding]; other site
351746014296	Switch I region; other site
351746014297	G2 box; other site
351746014298	G3 box; other site
351746014299	Switch II region; other site
351746014300	G4 box; other site
351746014301	G5 box; other site
351746014302	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
351746014303	Translation-initiation factor 2; Region: IF-2; pfam11987
351746014304	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
351746014305	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
351746014306	NusA N-terminal domain; Region: NusA_N; pfam08529
351746014307	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
351746014308	RNA binding site [nucleotide binding]; other site
351746014309	homodimer interface [polypeptide binding]; other site
351746014310	NusA-like KH domain; Region: KH_5; pfam13184
351746014311	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
351746014312	G-X-X-G motif; other site
351746014313	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
351746014314	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
351746014315	ribosome maturation protein RimP; Reviewed; Region: PRK00092
351746014316	Sm and related proteins; Region: Sm_like; cl00259
351746014317	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
351746014318	putative oligomer interface [polypeptide binding]; other site
351746014319	putative RNA binding site [nucleotide binding]; other site
351746014320	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
351746014321	triosephosphate isomerase; Provisional; Region: PRK14567
351746014322	substrate binding site [chemical binding]; other site
351746014323	dimer interface [polypeptide binding]; other site
351746014324	catalytic triad [active]
351746014325	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
351746014326	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
351746014327	active site
351746014328	substrate binding site [chemical binding]; other site
351746014329	metal binding site [ion binding]; metal-binding site
351746014330	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
351746014331	dihydropteroate synthase; Region: DHPS; TIGR01496
351746014332	substrate binding pocket [chemical binding]; other site
351746014333	dimer interface [polypeptide binding]; other site
351746014334	inhibitor binding site; inhibition site
351746014335	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
351746014336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746014337	Walker A motif; other site
351746014338	ATP binding site [chemical binding]; other site
351746014339	Walker B motif; other site
351746014340	arginine finger; other site
351746014341	Peptidase family M41; Region: Peptidase_M41; pfam01434
351746014342	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
351746014343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746014344	S-adenosylmethionine binding site [chemical binding]; other site
351746014345	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
351746014346	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
351746014347	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
351746014348	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
351746014349	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
351746014350	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351746014351	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
351746014352	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
351746014353	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351746014354	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351746014355	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
351746014356	IMP binding site; other site
351746014357	dimer interface [polypeptide binding]; other site
351746014358	interdomain contacts; other site
351746014359	partial ornithine binding site; other site
351746014360	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
351746014361	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
351746014362	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
351746014363	catalytic site [active]
351746014364	subunit interface [polypeptide binding]; other site
351746014365	dihydrodipicolinate reductase; Provisional; Region: PRK00048
351746014366	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
351746014367	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
351746014368	chaperone protein DnaJ; Provisional; Region: PRK10767
351746014369	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
351746014370	HSP70 interaction site [polypeptide binding]; other site
351746014371	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
351746014372	substrate binding site [polypeptide binding]; other site
351746014373	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
351746014374	Zn binding sites [ion binding]; other site
351746014375	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
351746014376	dimer interface [polypeptide binding]; other site
351746014377	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
351746014378	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
351746014379	nucleotide binding site [chemical binding]; other site
351746014380	NEF interaction site [polypeptide binding]; other site
351746014381	SBD interface [polypeptide binding]; other site
351746014382	GrpE; Region: GrpE; pfam01025
351746014383	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
351746014384	dimer interface [polypeptide binding]; other site
351746014385	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
351746014386	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
351746014387	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
351746014388	Walker A/P-loop; other site
351746014389	ATP binding site [chemical binding]; other site
351746014390	Q-loop/lid; other site
351746014391	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
351746014392	ABC transporter signature motif; other site
351746014393	Walker B; other site
351746014394	D-loop; other site
351746014395	H-loop/switch region; other site
351746014396	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
351746014397	metal binding site 2 [ion binding]; metal-binding site
351746014398	putative DNA binding helix; other site
351746014399	metal binding site 1 [ion binding]; metal-binding site
351746014400	dimer interface [polypeptide binding]; other site
351746014401	structural Zn2+ binding site [ion binding]; other site
351746014402	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
351746014403	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
351746014404	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
351746014405	putative coenzyme Q binding site [chemical binding]; other site
351746014406	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
351746014407	SmpB-tmRNA interface; other site
351746014408	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
351746014409	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746014410	DNA-binding site [nucleotide binding]; DNA binding site
351746014411	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746014412	glycolate transporter; Provisional; Region: PRK09695
351746014413	L-lactate permease; Region: Lactate_perm; cl00701
351746014414	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
351746014415	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
351746014416	phosphate binding site [ion binding]; other site
351746014417	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
351746014418	FAD binding domain; Region: FAD_binding_4; pfam01565
351746014419	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351746014420	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
351746014421	integrase; Provisional; Region: PRK09692
351746014422	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
351746014423	active site
351746014424	Int/Topo IB signature motif; other site
351746014425	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
351746014426	Integrase; Region: Integrase_1; pfam12835
351746014427	Protein of unknown function DUF262; Region: DUF262; pfam03235
351746014428	Protein of unknown function DUF262; Region: DUF262; pfam03235
351746014429	Uncharacterized conserved protein [Function unknown]; Region: COG1479
351746014430	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
351746014431	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
351746014432	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
351746014433	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
351746014434	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
351746014435	HsdM N-terminal domain; Region: HsdM_N; pfam12161
351746014436	Methyltransferase domain; Region: Methyltransf_26; pfam13659
351746014437	HNH endonuclease; Region: HNH_2; pfam13391
351746014438	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
351746014439	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
351746014440	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746014441	ATP binding site [chemical binding]; other site
351746014442	putative Mg++ binding site [ion binding]; other site
351746014443	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
351746014444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746014445	ATP binding site [chemical binding]; other site
351746014446	putative Mg++ binding site [ion binding]; other site
351746014447	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746014448	nucleotide binding region [chemical binding]; other site
351746014449	ATP-binding site [chemical binding]; other site
351746014450	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
351746014451	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
351746014452	ligand binding site [chemical binding]; other site
351746014453	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
351746014454	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
351746014455	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
351746014456	WYL domain; Region: WYL; pfam13280
351746014457	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746014458	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
351746014459	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746014460	N-terminal plug; other site
351746014461	ligand-binding site [chemical binding]; other site
351746014462	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
351746014463	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
351746014464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746014465	D-galactonate transporter; Region: 2A0114; TIGR00893
351746014466	putative substrate translocation pore; other site
351746014467	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
351746014468	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
351746014469	putative ligand binding site [chemical binding]; other site
351746014470	NAD binding site [chemical binding]; other site
351746014471	catalytic site [active]
351746014472	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
351746014473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746014474	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
351746014475	putative dimerization interface [polypeptide binding]; other site
351746014476	putative substrate binding pocket [chemical binding]; other site
351746014477	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
351746014478	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
351746014479	active site
351746014480	tetramer interface [polypeptide binding]; other site
351746014481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746014482	D-galactonate transporter; Region: 2A0114; TIGR00893
351746014483	putative substrate translocation pore; other site
351746014484	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351746014485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746014486	DNA-binding site [nucleotide binding]; DNA binding site
351746014487	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
351746014488	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
351746014489	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
351746014490	putative NAD(P) binding site [chemical binding]; other site
351746014491	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
351746014492	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746014493	active site
351746014494	motif I; other site
351746014495	motif II; other site
351746014496	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
351746014497	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
351746014498	active site
351746014499	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
351746014500	catalytic triad [active]
351746014501	dimer interface [polypeptide binding]; other site
351746014502	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351746014503	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
351746014504	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
351746014505	catalytic core [active]
351746014506	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
351746014507	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
351746014508	putative active site [active]
351746014509	Zn binding site [ion binding]; other site
351746014510	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
351746014511	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
351746014512	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
351746014513	ATP binding site [chemical binding]; other site
351746014514	Mg++ binding site [ion binding]; other site
351746014515	motif III; other site
351746014516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746014517	nucleotide binding region [chemical binding]; other site
351746014518	ATP-binding site [chemical binding]; other site
351746014519	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
351746014520	EamA-like transporter family; Region: EamA; pfam00892
351746014521	EamA-like transporter family; Region: EamA; pfam00892
351746014522	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
351746014523	active site
351746014524	catalytic site [active]
351746014525	substrate binding site [chemical binding]; other site
351746014526	Uncharacterized conserved protein [Function unknown]; Region: COG1432
351746014527	LabA_like proteins; Region: LabA; cd10911
351746014528	putative metal binding site [ion binding]; other site
351746014529	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
351746014530	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
351746014531	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746014532	ATP binding site [chemical binding]; other site
351746014533	putative Mg++ binding site [ion binding]; other site
351746014534	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746014535	nucleotide binding region [chemical binding]; other site
351746014536	ATP-binding site [chemical binding]; other site
351746014537	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
351746014538	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
351746014539	Cation efflux family; Region: Cation_efflux; cl00316
351746014540	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
351746014541	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746014542	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746014543	putative DNA binding site [nucleotide binding]; other site
351746014544	putative Zn2+ binding site [ion binding]; other site
351746014545	AsnC family; Region: AsnC_trans_reg; pfam01037
351746014546	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
351746014547	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
351746014548	pseudouridine synthase; Region: TIGR00093
351746014549	active site
351746014550	AMP nucleosidase; Provisional; Region: PRK08292
351746014551	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
351746014552	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
351746014553	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746014554	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351746014555	active site
351746014556	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
351746014557	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
351746014558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746014559	dimer interface [polypeptide binding]; other site
351746014560	phosphorylation site [posttranslational modification]
351746014561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746014562	ATP binding site [chemical binding]; other site
351746014563	Mg2+ binding site [ion binding]; other site
351746014564	G-X-G motif; other site
351746014565	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
351746014566	dimer interface [polypeptide binding]; other site
351746014567	substrate binding site [chemical binding]; other site
351746014568	ATP binding site [chemical binding]; other site
351746014569	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
351746014570	thiamine phosphate binding site [chemical binding]; other site
351746014571	active site
351746014572	pyrophosphate binding site [ion binding]; other site
351746014573	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
351746014574	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746014575	inhibitor-cofactor binding pocket; inhibition site
351746014576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746014577	catalytic residue [active]
351746014578	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
351746014579	Sel1-like repeats; Region: SEL1; smart00671
351746014580	Sel1-like repeats; Region: SEL1; smart00671
351746014581	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
351746014582	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
351746014583	PhoH-like protein; Region: PhoH; pfam02562
351746014584	metal-binding heat shock protein; Provisional; Region: PRK00016
351746014585	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
351746014586	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
351746014587	Transporter associated domain; Region: CorC_HlyC; smart01091
351746014588	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
351746014589	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
351746014590	putative active site [active]
351746014591	catalytic triad [active]
351746014592	putative dimer interface [polypeptide binding]; other site
351746014593	Uncharacterized conserved protein [Function unknown]; Region: COG1434
351746014594	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
351746014595	putative active site [active]
351746014596	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
351746014597	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
351746014598	HIGH motif; other site
351746014599	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
351746014600	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
351746014601	active site
351746014602	KMSKS motif; other site
351746014603	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
351746014604	tRNA binding surface [nucleotide binding]; other site
351746014605	Lipopolysaccharide-assembly; Region: LptE; cl01125
351746014606	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
351746014607	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
351746014608	Domain of unknown function; Region: DUF331; cl01149
351746014609	Transglycosylase SLT domain; Region: SLT_2; pfam13406
351746014610	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746014611	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746014612	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
351746014613	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
351746014614	dimer interface [polypeptide binding]; other site
351746014615	catalytic triad [active]
351746014616	lipoyl synthase; Provisional; Region: PRK05481
351746014617	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746014618	FeS/SAM binding site; other site
351746014619	lipoate-protein ligase B; Provisional; Region: PRK14342
351746014620	hypothetical protein; Provisional; Region: PRK00341
351746014621	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
351746014622	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
351746014623	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
351746014624	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
351746014625	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
351746014626	Sporulation related domain; Region: SPOR; pfam05036
351746014627	Transglycosylase SLT domain; Region: SLT_2; pfam13406
351746014628	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351746014629	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351746014630	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
351746014631	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
351746014632	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
351746014633	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351746014634	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
351746014635	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
351746014636	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
351746014637	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
351746014638	active site
351746014639	(T/H)XGH motif; other site
351746014640	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
351746014641	putative catalytic cysteine [active]
351746014642	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
351746014643	active site
351746014644	DNA binding site [nucleotide binding]
351746014645	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
351746014646	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
351746014647	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
351746014648	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
351746014649	active site
351746014650	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
351746014651	LrgB-like family; Region: LrgB; pfam04172
351746014652	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
351746014653	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
351746014654	putative active site [active]
351746014655	putative catalytic site [active]
351746014656	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
351746014657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351746014658	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
351746014659	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
351746014660	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
351746014661	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
351746014662	FMN binding site [chemical binding]; other site
351746014663	active site
351746014664	catalytic residues [active]
351746014665	substrate binding site [chemical binding]; other site
351746014666	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
351746014667	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
351746014668	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
351746014669	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
351746014670	purine monophosphate binding site [chemical binding]; other site
351746014671	dimer interface [polypeptide binding]; other site
351746014672	putative catalytic residues [active]
351746014673	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
351746014674	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
351746014675	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
351746014676	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
351746014677	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
351746014678	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
351746014679	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
351746014680	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
351746014681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746014682	dimer interface [polypeptide binding]; other site
351746014683	phosphorylation site [posttranslational modification]
351746014684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746014685	ATP binding site [chemical binding]; other site
351746014686	Mg2+ binding site [ion binding]; other site
351746014687	G-X-G motif; other site
351746014688	Response regulator receiver domain; Region: Response_reg; pfam00072
351746014689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746014690	active site
351746014691	phosphorylation site [posttranslational modification]
351746014692	intermolecular recognition site; other site
351746014693	dimerization interface [polypeptide binding]; other site
351746014694	Response regulator receiver domain; Region: Response_reg; pfam00072
351746014695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746014696	active site
351746014697	phosphorylation site [posttranslational modification]
351746014698	intermolecular recognition site; other site
351746014699	dimerization interface [polypeptide binding]; other site
351746014700	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
351746014701	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
351746014702	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
351746014703	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
351746014704	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
351746014705	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
351746014706	active site
351746014707	SAM binding site [chemical binding]; other site
351746014708	homodimer interface [polypeptide binding]; other site
351746014709	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
351746014710	homodimer interface [polypeptide binding]; other site
351746014711	active site
351746014712	SAM binding site [chemical binding]; other site
351746014713	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
351746014714	Precorrin-8X methylmutase; Region: CbiC; pfam02570
351746014715	precorrin-3B synthase; Region: CobG; TIGR02435
351746014716	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
351746014717	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
351746014718	active site
351746014719	putative homodimer interface [polypeptide binding]; other site
351746014720	SAM binding site [chemical binding]; other site
351746014721	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
351746014722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746014723	S-adenosylmethionine binding site [chemical binding]; other site
351746014724	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
351746014725	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
351746014726	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
351746014727	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
351746014728	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
351746014729	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
351746014730	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
351746014731	Protein of unknown function (DUF461); Region: DUF461; pfam04314
351746014732	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
351746014733	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
351746014734	N-terminal plug; other site
351746014735	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
351746014736	ligand-binding site [chemical binding]; other site
351746014737	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
351746014738	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
351746014739	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
351746014740	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
351746014741	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
351746014742	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
351746014743	Spore germination protein; Region: Spore_permease; cl17796
351746014744	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351746014745	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
351746014746	putative ligand binding site [chemical binding]; other site
351746014747	HEAT repeats; Region: HEAT_2; pfam13646
351746014748	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351746014749	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746014750	TM-ABC transporter signature motif; other site
351746014751	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
351746014752	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351746014753	TM-ABC transporter signature motif; other site
351746014754	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
351746014755	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351746014756	Walker A/P-loop; other site
351746014757	ATP binding site [chemical binding]; other site
351746014758	Q-loop/lid; other site
351746014759	ABC transporter signature motif; other site
351746014760	Walker B; other site
351746014761	D-loop; other site
351746014762	H-loop/switch region; other site
351746014763	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
351746014764	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351746014765	Walker A/P-loop; other site
351746014766	ATP binding site [chemical binding]; other site
351746014767	Q-loop/lid; other site
351746014768	ABC transporter signature motif; other site
351746014769	Walker B; other site
351746014770	D-loop; other site
351746014771	H-loop/switch region; other site
351746014772	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
351746014773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746014774	Coenzyme A binding pocket [chemical binding]; other site
351746014775	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
351746014776	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
351746014777	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
351746014778	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
351746014779	HSP70 interaction site [polypeptide binding]; other site
351746014780	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
351746014781	substrate binding site [polypeptide binding]; other site
351746014782	dimer interface [polypeptide binding]; other site
351746014783	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
351746014784	putative chaperone; Provisional; Region: PRK11678
351746014785	nucleotide binding site [chemical binding]; other site
351746014786	putative NEF/HSP70 interaction site [polypeptide binding]; other site
351746014787	SBD interface [polypeptide binding]; other site
351746014788	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
351746014789	hypothetical protein; Provisional; Region: PRK11505
351746014790	psiF repeat; Region: PsiF_repeat; pfam07769
351746014791	psiF repeat; Region: PsiF_repeat; pfam07769
351746014792	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351746014793	Helix-turn-helix domain; Region: HTH_18; pfam12833
351746014794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746014795	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351746014796	EamA-like transporter family; Region: EamA; pfam00892
351746014797	EamA-like transporter family; Region: EamA; pfam00892
351746014798	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
351746014799	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
351746014800	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
351746014801	Ferritin-like domain; Region: Ferritin; pfam00210
351746014802	dinuclear metal binding motif [ion binding]; other site
351746014803	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
351746014804	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
351746014805	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
351746014806	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
351746014807	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746014808	dimerization interface [polypeptide binding]; other site
351746014809	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
351746014810	putative active cleft [active]
351746014811	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
351746014812	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
351746014813	putative NAD(P) binding site [chemical binding]; other site
351746014814	homotetramer interface [polypeptide binding]; other site
351746014815	homodimer interface [polypeptide binding]; other site
351746014816	active site
351746014817	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
351746014818	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351746014819	Walker A/P-loop; other site
351746014820	ATP binding site [chemical binding]; other site
351746014821	Q-loop/lid; other site
351746014822	ABC transporter signature motif; other site
351746014823	Walker B; other site
351746014824	D-loop; other site
351746014825	H-loop/switch region; other site
351746014826	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
351746014827	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351746014828	Walker A/P-loop; other site
351746014829	ATP binding site [chemical binding]; other site
351746014830	Q-loop/lid; other site
351746014831	ABC transporter signature motif; other site
351746014832	Walker B; other site
351746014833	D-loop; other site
351746014834	H-loop/switch region; other site
351746014835	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
351746014836	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
351746014837	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351746014838	TM-ABC transporter signature motif; other site
351746014839	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351746014840	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351746014841	TM-ABC transporter signature motif; other site
351746014842	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
351746014843	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
351746014844	dimerization interface [polypeptide binding]; other site
351746014845	ligand binding site [chemical binding]; other site
351746014846	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
351746014847	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
351746014848	active site
351746014849	NAD+ synthetase; Region: nadE; TIGR00552
351746014850	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
351746014851	homodimer interface [polypeptide binding]; other site
351746014852	NAD binding pocket [chemical binding]; other site
351746014853	ATP binding pocket [chemical binding]; other site
351746014854	Mg binding site [ion binding]; other site
351746014855	active-site loop [active]
351746014856	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
351746014857	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
351746014858	hypothetical protein; Provisional; Region: PRK01254
351746014859	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
351746014860	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
351746014861	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746014862	YcaO-like family; Region: YcaO; pfam02624
351746014863	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351746014864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746014865	Walker A/P-loop; other site
351746014866	ATP binding site [chemical binding]; other site
351746014867	Q-loop/lid; other site
351746014868	ABC transporter signature motif; other site
351746014869	Walker B; other site
351746014870	D-loop; other site
351746014871	H-loop/switch region; other site
351746014872	replicative DNA helicase; Provisional; Region: PRK05748
351746014873	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
351746014874	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
351746014875	Walker A motif; other site
351746014876	ATP binding site [chemical binding]; other site
351746014877	Walker B motif; other site
351746014878	DNA binding loops [nucleotide binding]
351746014879	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
351746014880	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
351746014881	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
351746014882	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
351746014883	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
351746014884	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
351746014885	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
351746014886	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
351746014887	ribonuclease R; Region: RNase_R; TIGR02063
351746014888	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
351746014889	RNB domain; Region: RNB; pfam00773
351746014890	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
351746014891	RNA binding site [nucleotide binding]; other site
351746014892	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351746014893	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
351746014894	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
351746014895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746014896	dimer interface [polypeptide binding]; other site
351746014897	conserved gate region; other site
351746014898	putative PBP binding loops; other site
351746014899	ABC-ATPase subunit interface; other site
351746014900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746014901	dimer interface [polypeptide binding]; other site
351746014902	conserved gate region; other site
351746014903	putative PBP binding loops; other site
351746014904	ABC-ATPase subunit interface; other site
351746014905	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
351746014906	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746014907	dimerization interface [polypeptide binding]; other site
351746014908	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746014909	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746014910	dimer interface [polypeptide binding]; other site
351746014911	putative CheW interface [polypeptide binding]; other site
351746014912	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
351746014913	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
351746014914	GDP-binding site [chemical binding]; other site
351746014915	ACT binding site; other site
351746014916	IMP binding site; other site
351746014917	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
351746014918	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
351746014919	dimer interface [polypeptide binding]; other site
351746014920	motif 1; other site
351746014921	active site
351746014922	motif 2; other site
351746014923	motif 3; other site
351746014924	FtsH protease regulator HflC; Provisional; Region: PRK11029
351746014925	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
351746014926	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
351746014927	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
351746014928	HflK protein; Region: hflK; TIGR01933
351746014929	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
351746014930	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
351746014931	HflX GTPase family; Region: HflX; cd01878
351746014932	G1 box; other site
351746014933	GTP/Mg2+ binding site [chemical binding]; other site
351746014934	Switch I region; other site
351746014935	G2 box; other site
351746014936	G3 box; other site
351746014937	Switch II region; other site
351746014938	G4 box; other site
351746014939	G5 box; other site
351746014940	bacterial Hfq-like; Region: Hfq; cd01716
351746014941	hexamer interface [polypeptide binding]; other site
351746014942	Sm1 motif; other site
351746014943	RNA binding site [nucleotide binding]; other site
351746014944	Sm2 motif; other site
351746014945	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
351746014946	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
351746014947	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
351746014948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746014949	ATP binding site [chemical binding]; other site
351746014950	Mg2+ binding site [ion binding]; other site
351746014951	G-X-G motif; other site
351746014952	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
351746014953	ATP binding site [chemical binding]; other site
351746014954	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
351746014955	AMIN domain; Region: AMIN; pfam11741
351746014956	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
351746014957	active site
351746014958	metal binding site [ion binding]; metal-binding site
351746014959	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351746014960	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
351746014961	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
351746014962	putative ATP binding site [chemical binding]; other site
351746014963	putative substrate binding site [chemical binding]; other site
351746014964	epoxyqueuosine reductase; Region: TIGR00276
351746014965	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
351746014966	Predicted membrane protein [Function unknown]; Region: COG2860
351746014967	UPF0126 domain; Region: UPF0126; pfam03458
351746014968	UPF0126 domain; Region: UPF0126; pfam03458
351746014969	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
351746014970	catalytic site [active]
351746014971	putative active site [active]
351746014972	putative substrate binding site [chemical binding]; other site
351746014973	dimer interface [polypeptide binding]; other site
351746014974	GTPase RsgA; Reviewed; Region: PRK12288
351746014975	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351746014976	RNA binding site [nucleotide binding]; other site
351746014977	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
351746014978	GTPase/Zn-binding domain interface [polypeptide binding]; other site
351746014979	GTP/Mg2+ binding site [chemical binding]; other site
351746014980	G4 box; other site
351746014981	G5 box; other site
351746014982	G1 box; other site
351746014983	Switch I region; other site
351746014984	G2 box; other site
351746014985	G3 box; other site
351746014986	Switch II region; other site
351746014987	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
351746014988	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
351746014989	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351746014990	ligand binding site [chemical binding]; other site
351746014991	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
351746014992	flagellar motor protein MotA; Validated; Region: PRK09110
351746014993	HDOD domain; Region: HDOD; pfam08668
351746014994	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
351746014995	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
351746014996	active site residue [active]
351746014997	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
351746014998	active site residue [active]
351746014999	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
351746015000	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
351746015001	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
351746015002	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
351746015003	phosphoserine phosphatase SerB; Region: serB; TIGR00338
351746015004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746015005	motif II; other site
351746015006	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
351746015007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
351746015008	Protein of unknown function (DUF330); Region: DUF330; pfam03886
351746015009	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
351746015010	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
351746015011	CAP-like domain; other site
351746015012	active site
351746015013	primary dimer interface [polypeptide binding]; other site
351746015014	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
351746015015	catalytic motif [active]
351746015016	Catalytic residue [active]
351746015017	SdiA-regulated; Region: SdiA-regulated; cd09971
351746015018	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
351746015019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746015020	ATP binding site [chemical binding]; other site
351746015021	Mg2+ binding site [ion binding]; other site
351746015022	G-X-G motif; other site
351746015023	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
351746015024	anchoring element; other site
351746015025	dimer interface [polypeptide binding]; other site
351746015026	ATP binding site [chemical binding]; other site
351746015027	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
351746015028	active site
351746015029	metal binding site [ion binding]; metal-binding site
351746015030	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
351746015031	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
351746015032	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351746015033	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
351746015034	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
351746015035	active site
351746015036	metal binding site [ion binding]; metal-binding site
351746015037	hexamer interface [polypeptide binding]; other site
351746015038	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
351746015039	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
351746015040	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
351746015041	dimer interface [polypeptide binding]; other site
351746015042	ADP-ribose binding site [chemical binding]; other site
351746015043	active site
351746015044	nudix motif; other site
351746015045	metal binding site [ion binding]; metal-binding site
351746015046	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
351746015047	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
351746015048	Na binding site [ion binding]; other site
351746015049	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
351746015050	ThiC-associated domain; Region: ThiC-associated; pfam13667
351746015051	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
351746015052	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
351746015053	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
351746015054	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
351746015055	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
351746015056	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746015057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746015058	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746015059	dimerization interface [polypeptide binding]; other site
351746015060	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
351746015061	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
351746015062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746015063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351746015064	active site
351746015065	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351746015066	catalytic tetrad [active]
351746015067	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
351746015068	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
351746015069	putative ribose interaction site [chemical binding]; other site
351746015070	putative ADP binding site [chemical binding]; other site
351746015071	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
351746015072	active site
351746015073	nucleotide binding site [chemical binding]; other site
351746015074	HIGH motif; other site
351746015075	KMSKS motif; other site
351746015076	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
351746015077	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351746015078	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
351746015079	Walker A/P-loop; other site
351746015080	ATP binding site [chemical binding]; other site
351746015081	Q-loop/lid; other site
351746015082	ABC transporter signature motif; other site
351746015083	Walker B; other site
351746015084	D-loop; other site
351746015085	H-loop/switch region; other site
351746015086	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
351746015087	O-Antigen ligase; Region: Wzy_C; pfam04932
351746015088	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
351746015089	active site
351746015090	substrate binding site [chemical binding]; other site
351746015091	ATP binding site [chemical binding]; other site
351746015092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746015093	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
351746015094	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746015095	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
351746015096	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
351746015097	Mig-14; Region: Mig-14; pfam07395
351746015098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
351746015099	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
351746015100	putative ADP-binding pocket [chemical binding]; other site
351746015101	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351746015102	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
351746015103	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
351746015104	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
351746015105	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
351746015106	Na binding site [ion binding]; other site
351746015107	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
351746015108	Predicted transcriptional regulator [Transcription]; Region: COG3905
351746015109	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
351746015110	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
351746015111	Glutamate binding site [chemical binding]; other site
351746015112	NAD binding site [chemical binding]; other site
351746015113	catalytic residues [active]
351746015114	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
351746015115	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
351746015116	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
351746015117	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351746015118	active site
351746015119	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
351746015120	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
351746015121	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
351746015122	putative transporter; Provisional; Region: PRK10504
351746015123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746015124	putative substrate translocation pore; other site
351746015125	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
351746015126	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
351746015127	ATP binding site [chemical binding]; other site
351746015128	Mg++ binding site [ion binding]; other site
351746015129	motif III; other site
351746015130	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746015131	nucleotide binding region [chemical binding]; other site
351746015132	ATP-binding site [chemical binding]; other site
351746015133	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
351746015134	putative RNA binding site [nucleotide binding]; other site
351746015135	HI0933-like protein; Region: HI0933_like; pfam03486
351746015136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746015137	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
351746015138	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
351746015139	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
351746015140	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746015141	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746015142	substrate binding pocket [chemical binding]; other site
351746015143	membrane-bound complex binding site; other site
351746015144	hinge residues; other site
351746015145	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351746015146	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
351746015147	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
351746015148	Response regulator receiver domain; Region: Response_reg; pfam00072
351746015149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746015150	active site
351746015151	phosphorylation site [posttranslational modification]
351746015152	intermolecular recognition site; other site
351746015153	dimerization interface [polypeptide binding]; other site
351746015154	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746015155	PAS domain; Region: PAS_9; pfam13426
351746015156	putative active site [active]
351746015157	heme pocket [chemical binding]; other site
351746015158	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746015159	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746015160	metal binding site [ion binding]; metal-binding site
351746015161	active site
351746015162	I-site; other site
351746015163	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746015164	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
351746015165	intersubunit interface [polypeptide binding]; other site
351746015166	active site
351746015167	zinc binding site [ion binding]; other site
351746015168	Na+ binding site [ion binding]; other site
351746015169	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
351746015170	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
351746015171	Phosphoglycerate kinase; Region: PGK; pfam00162
351746015172	substrate binding site [chemical binding]; other site
351746015173	hinge regions; other site
351746015174	ADP binding site [chemical binding]; other site
351746015175	catalytic site [active]
351746015176	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
351746015177	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
351746015178	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
351746015179	transketolase; Reviewed; Region: PRK12753
351746015180	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
351746015181	TPP-binding site [chemical binding]; other site
351746015182	dimer interface [polypeptide binding]; other site
351746015183	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
351746015184	PYR/PP interface [polypeptide binding]; other site
351746015185	dimer interface [polypeptide binding]; other site
351746015186	TPP binding site [chemical binding]; other site
351746015187	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351746015188	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746015189	putative DNA binding site [nucleotide binding]; other site
351746015190	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351746015191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746015192	S-adenosylmethionine binding site [chemical binding]; other site
351746015193	S-adenosylmethionine synthetase; Validated; Region: PRK05250
351746015194	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
351746015195	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
351746015196	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
351746015197	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
351746015198	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
351746015199	nucleotide binding pocket [chemical binding]; other site
351746015200	K-X-D-G motif; other site
351746015201	catalytic site [active]
351746015202	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
351746015203	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
351746015204	Cytochrome C' Region: Cytochrom_C_2; pfam01322
351746015205	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
351746015206	MltA specific insert domain; Region: MltA; pfam03562
351746015207	3D domain; Region: 3D; pfam06725
351746015208	MAPEG family; Region: MAPEG; cl09190
351746015209	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
351746015210	EamA-like transporter family; Region: EamA; pfam00892
351746015211	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
351746015212	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
351746015213	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
351746015214	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
351746015215	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
351746015216	homotetramer interface [polypeptide binding]; other site
351746015217	ligand binding site [chemical binding]; other site
351746015218	catalytic site [active]
351746015219	NAD binding site [chemical binding]; other site
351746015220	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
351746015221	FAD binding site [chemical binding]; other site
351746015222	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746015223	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746015224	substrate binding pocket [chemical binding]; other site
351746015225	membrane-bound complex binding site; other site
351746015226	hinge residues; other site
351746015227	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
351746015228	DEAD-like helicases superfamily; Region: DEXDc; smart00487
351746015229	ATP binding site [chemical binding]; other site
351746015230	Mg++ binding site [ion binding]; other site
351746015231	motif III; other site
351746015232	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746015233	nucleotide binding region [chemical binding]; other site
351746015234	ATP-binding site [chemical binding]; other site
351746015235	hypothetical protein; Provisional; Region: PRK03757
351746015236	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
351746015237	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
351746015238	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
351746015239	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746015240	inhibitor-cofactor binding pocket; inhibition site
351746015241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746015242	catalytic residue [active]
351746015243	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
351746015244	RNA methyltransferase, RsmE family; Region: TIGR00046
351746015245	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
351746015246	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
351746015247	CheW-like domain; Region: CheW; pfam01584
351746015248	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746015249	putative binding surface; other site
351746015250	active site
351746015251	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746015252	putative binding surface; other site
351746015253	active site
351746015254	Hpt domain; Region: Hpt; pfam01627
351746015255	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351746015256	putative binding surface; other site
351746015257	active site
351746015258	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
351746015259	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
351746015260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746015261	ATP binding site [chemical binding]; other site
351746015262	Mg2+ binding site [ion binding]; other site
351746015263	G-X-G motif; other site
351746015264	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
351746015265	Response regulator receiver domain; Region: Response_reg; pfam00072
351746015266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746015267	active site
351746015268	phosphorylation site [posttranslational modification]
351746015269	intermolecular recognition site; other site
351746015270	dimerization interface [polypeptide binding]; other site
351746015271	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
351746015272	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746015273	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746015274	dimer interface [polypeptide binding]; other site
351746015275	putative CheW interface [polypeptide binding]; other site
351746015276	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351746015277	Response regulator receiver domain; Region: Response_reg; pfam00072
351746015278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746015279	active site
351746015280	phosphorylation site [posttranslational modification]
351746015281	intermolecular recognition site; other site
351746015282	dimerization interface [polypeptide binding]; other site
351746015283	Response regulator receiver domain; Region: Response_reg; pfam00072
351746015284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746015285	active site
351746015286	phosphorylation site [posttranslational modification]
351746015287	intermolecular recognition site; other site
351746015288	dimerization interface [polypeptide binding]; other site
351746015289	glutathione synthetase; Provisional; Region: PRK05246
351746015290	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
351746015291	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
351746015292	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
351746015293	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
351746015294	hypothetical protein; Validated; Region: PRK00228
351746015295	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
351746015296	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
351746015297	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746015298	active site
351746015299	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
351746015300	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
351746015301	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
351746015302	dihydroorotase; Validated; Region: pyrC; PRK09357
351746015303	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
351746015304	active site
351746015305	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
351746015306	active site
351746015307	HslU subunit interaction site [polypeptide binding]; other site
351746015308	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
351746015309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746015310	Walker A motif; other site
351746015311	ATP binding site [chemical binding]; other site
351746015312	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
351746015313	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
351746015314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
351746015315	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
351746015316	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
351746015317	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
351746015318	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
351746015319	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
351746015320	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
351746015321	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746015322	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746015323	Bacterial transcriptional repressor; Region: TetR; pfam13972
351746015324	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
351746015325	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
351746015326	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
351746015327	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
351746015328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746015329	S-adenosylmethionine binding site [chemical binding]; other site
351746015330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
351746015331	SCP-2 sterol transfer family; Region: SCP2; pfam02036
351746015332	ABC1 family; Region: ABC1; cl17513
351746015333	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
351746015334	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
351746015335	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
351746015336	metal binding site [ion binding]; metal-binding site
351746015337	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
351746015338	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
351746015339	sec-independent translocase; Provisional; Region: tatB; PRK00404
351746015340	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
351746015341	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
351746015342	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
351746015343	RNA methyltransferase, RsmE family; Region: TIGR00046
351746015344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746015345	dimerization interface [polypeptide binding]; other site
351746015346	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746015347	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746015348	dimer interface [polypeptide binding]; other site
351746015349	putative CheW interface [polypeptide binding]; other site
351746015350	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746015351	dimerization interface [polypeptide binding]; other site
351746015352	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351746015353	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351746015354	dimer interface [polypeptide binding]; other site
351746015355	putative CheW interface [polypeptide binding]; other site
351746015356	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
351746015357	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351746015358	Walker A/P-loop; other site
351746015359	ATP binding site [chemical binding]; other site
351746015360	Q-loop/lid; other site
351746015361	ABC transporter signature motif; other site
351746015362	Walker B; other site
351746015363	D-loop; other site
351746015364	H-loop/switch region; other site
351746015365	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351746015366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015367	dimer interface [polypeptide binding]; other site
351746015368	conserved gate region; other site
351746015369	putative PBP binding loops; other site
351746015370	ABC-ATPase subunit interface; other site
351746015371	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351746015372	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746015373	substrate binding pocket [chemical binding]; other site
351746015374	membrane-bound complex binding site; other site
351746015375	hinge residues; other site
351746015376	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
351746015377	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
351746015378	Ligand binding site; other site
351746015379	DXD motif; other site
351746015380	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
351746015381	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
351746015382	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
351746015383	putative active site [active]
351746015384	dimerization interface [polypeptide binding]; other site
351746015385	putative tRNAtyr binding site [nucleotide binding]; other site
351746015386	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
351746015387	TAP-like protein; Region: Abhydrolase_4; pfam08386
351746015388	N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017
351746015389	imidazolonepropionase; Validated; Region: PRK09356
351746015390	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
351746015391	active site
351746015392	putative proline-specific permease; Provisional; Region: proY; PRK10580
351746015393	Spore germination protein; Region: Spore_permease; cl17796
351746015394	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
351746015395	active sites [active]
351746015396	tetramer interface [polypeptide binding]; other site
351746015397	urocanate hydratase; Provisional; Region: PRK05414
351746015398	HutD; Region: HutD; pfam05962
351746015399	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
351746015400	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746015401	DNA-binding site [nucleotide binding]; DNA binding site
351746015402	UTRA domain; Region: UTRA; pfam07702
351746015403	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
351746015404	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
351746015405	active site
351746015406	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
351746015407	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
351746015408	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
351746015409	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
351746015410	fructose-1,6-bisphosphatase family protein; Region: PLN02628
351746015411	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
351746015412	AMP binding site [chemical binding]; other site
351746015413	metal binding site [ion binding]; metal-binding site
351746015414	active site
351746015415	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
351746015416	homodimer interface [polypeptide binding]; other site
351746015417	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
351746015418	active site pocket [active]
351746015419	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
351746015420	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142
351746015421	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
351746015422	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
351746015423	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
351746015424	G1 box; other site
351746015425	putative GEF interaction site [polypeptide binding]; other site
351746015426	GTP/Mg2+ binding site [chemical binding]; other site
351746015427	Switch I region; other site
351746015428	G2 box; other site
351746015429	G3 box; other site
351746015430	Switch II region; other site
351746015431	G4 box; other site
351746015432	G5 box; other site
351746015433	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
351746015434	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
351746015435	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
351746015436	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
351746015437	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
351746015438	Ligand Binding Site [chemical binding]; other site
351746015439	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
351746015440	glutamine synthetase; Provisional; Region: glnA; PRK09469
351746015441	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
351746015442	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746015443	chorismate mutase; Provisional; Region: PRK09269
351746015444	Chorismate mutase type II; Region: CM_2; cl00693
351746015445	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
351746015446	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746015447	dimer interface [polypeptide binding]; other site
351746015448	phosphorylation site [posttranslational modification]
351746015449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746015450	ATP binding site [chemical binding]; other site
351746015451	Mg2+ binding site [ion binding]; other site
351746015452	G-X-G motif; other site
351746015453	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
351746015454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746015455	active site
351746015456	phosphorylation site [posttranslational modification]
351746015457	intermolecular recognition site; other site
351746015458	dimerization interface [polypeptide binding]; other site
351746015459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746015460	Walker A motif; other site
351746015461	ATP binding site [chemical binding]; other site
351746015462	Walker B motif; other site
351746015463	arginine finger; other site
351746015464	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
351746015465	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
351746015466	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
351746015467	SecA binding site; other site
351746015468	Preprotein binding site; other site
351746015469	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
351746015470	GSH binding site [chemical binding]; other site
351746015471	catalytic residues [active]
351746015472	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
351746015473	active site residue [active]
351746015474	phosphoglyceromutase; Provisional; Region: PRK05434
351746015475	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
351746015476	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
351746015477	Peptidase family M23; Region: Peptidase_M23; pfam01551
351746015478	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
351746015479	C-terminal peptidase (prc); Region: prc; TIGR00225
351746015480	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
351746015481	protein binding site [polypeptide binding]; other site
351746015482	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
351746015483	Catalytic dyad [active]
351746015484	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
351746015485	NodB motif; other site
351746015486	putative active site [active]
351746015487	putative catalytic site [active]
351746015488	Zn binding site [ion binding]; other site
351746015489	BCCT family transporter; Region: BCCT; cl00569
351746015490	transcriptional regulator BetI; Validated; Region: PRK00767
351746015491	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746015492	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
351746015493	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
351746015494	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
351746015495	NAD(P) binding site [chemical binding]; other site
351746015496	catalytic residues [active]
351746015497	choline dehydrogenase; Validated; Region: PRK02106
351746015498	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
351746015499	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
351746015500	potassium/proton antiporter; Reviewed; Region: PRK05326
351746015501	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
351746015502	TrkA-C domain; Region: TrkA_C; pfam02080
351746015503	Transporter associated domain; Region: CorC_HlyC; smart01091
351746015504	hypothetical protein; Provisional; Region: PRK11281
351746015505	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
351746015506	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746015507	Uncharacterized conserved protein [Function unknown]; Region: COG0397
351746015508	hypothetical protein; Validated; Region: PRK00029
351746015509	thioredoxin 2; Provisional; Region: PRK10996
351746015510	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
351746015511	catalytic residues [active]
351746015512	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
351746015513	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746015514	P-loop; other site
351746015515	Magnesium ion binding site [ion binding]; other site
351746015516	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746015517	Magnesium ion binding site [ion binding]; other site
351746015518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746015519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746015520	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
351746015521	dimerization interface [polypeptide binding]; other site
351746015522	substrate binding pocket [chemical binding]; other site
351746015523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746015524	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351746015525	putative substrate translocation pore; other site
351746015526	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
351746015527	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
351746015528	substrate binding site [chemical binding]; other site
351746015529	active site
351746015530	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
351746015531	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351746015532	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351746015533	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
351746015534	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
351746015535	active site
351746015536	dimer interface [polypeptide binding]; other site
351746015537	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
351746015538	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
351746015539	active site
351746015540	FMN binding site [chemical binding]; other site
351746015541	substrate binding site [chemical binding]; other site
351746015542	3Fe-4S cluster binding site [ion binding]; other site
351746015543	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
351746015544	domain interface; other site
351746015545	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
351746015546	Sporulation related domain; Region: SPOR; pfam05036
351746015547	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
351746015548	active site
351746015549	dimer interface [polypeptide binding]; other site
351746015550	metal binding site [ion binding]; metal-binding site
351746015551	shikimate kinase; Reviewed; Region: aroK; PRK00131
351746015552	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
351746015553	ADP binding site [chemical binding]; other site
351746015554	magnesium binding site [ion binding]; other site
351746015555	putative shikimate binding site; other site
351746015556	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
351746015557	Secretin and TonB N terminus short domain; Region: STN; smart00965
351746015558	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
351746015559	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
351746015560	Pilus assembly protein, PilO; Region: PilO; cl01234
351746015561	Pilus assembly protein, PilP; Region: PilP; pfam04351
351746015562	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
351746015563	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
351746015564	Competence protein A; Region: Competence_A; pfam11104
351746015565	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
351746015566	Transglycosylase; Region: Transgly; pfam00912
351746015567	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
351746015568	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
351746015569	Malic enzyme, N-terminal domain; Region: malic; pfam00390
351746015570	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
351746015571	putative NAD(P) binding site [chemical binding]; other site
351746015572	Staphylococcal nuclease homologues; Region: SNc; smart00318
351746015573	Catalytic site; other site
351746015574	Staphylococcal nuclease homologue; Region: SNase; pfam00565
351746015575	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
351746015576	primosome assembly protein PriA; Validated; Region: PRK05580
351746015577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746015578	ATP binding site [chemical binding]; other site
351746015579	putative Mg++ binding site [ion binding]; other site
351746015580	helicase superfamily c-terminal domain; Region: HELICc; smart00490
351746015581	ATP-binding site [chemical binding]; other site
351746015582	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
351746015583	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
351746015584	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
351746015585	active site
351746015586	HIGH motif; other site
351746015587	KMSK motif region; other site
351746015588	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
351746015589	tRNA binding surface [nucleotide binding]; other site
351746015590	anticodon binding site; other site
351746015591	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
351746015592	Sporulation related domain; Region: SPOR; pfam05036
351746015593	TM2 domain; Region: TM2; cl00984
351746015594	TM2 domain; Region: TM2; cl00984
351746015595	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
351746015596	NlpC/P60 family; Region: NLPC_P60; pfam00877
351746015597	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
351746015598	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746015599	Walker A motif; other site
351746015600	ATP binding site [chemical binding]; other site
351746015601	Walker B motif; other site
351746015602	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
351746015603	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746015604	catalytic residue [active]
351746015605	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
351746015606	pyrroline-5-carboxylate reductase; Region: PLN02688
351746015607	YGGT family; Region: YGGT; pfam02325
351746015608	YGGT family; Region: YGGT; pfam02325
351746015609	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
351746015610	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
351746015611	hypothetical protein; Provisional; Region: PRK08317
351746015612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746015613	S-adenosylmethionine binding site [chemical binding]; other site
351746015614	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
351746015615	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
351746015616	active site
351746015617	dimerization interface [polypeptide binding]; other site
351746015618	HemN family oxidoreductase; Provisional; Region: PRK05660
351746015619	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351746015620	FeS/SAM binding site; other site
351746015621	HemN C-terminal domain; Region: HemN_C; pfam06969
351746015622	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
351746015623	Methyltransferase domain; Region: Methyltransf_31; pfam13847
351746015624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746015625	S-adenosylmethionine binding site [chemical binding]; other site
351746015626	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
351746015627	ThiS interaction site; other site
351746015628	putative active site [active]
351746015629	tetramer interface [polypeptide binding]; other site
351746015630	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
351746015631	thiS-thiF/thiG interaction site; other site
351746015632	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
351746015633	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
351746015634	Transglycosylase; Region: Transgly; cl17702
351746015635	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
351746015636	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351746015637	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351746015638	DNA binding residues [nucleotide binding]
351746015639	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
351746015640	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
351746015641	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
351746015642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746015643	Walker A/P-loop; other site
351746015644	ATP binding site [chemical binding]; other site
351746015645	Q-loop/lid; other site
351746015646	ABC transporter signature motif; other site
351746015647	Walker B; other site
351746015648	D-loop; other site
351746015649	H-loop/switch region; other site
351746015650	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
351746015651	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
351746015652	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
351746015653	P loop; other site
351746015654	GTP binding site [chemical binding]; other site
351746015655	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351746015656	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
351746015657	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351746015658	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351746015659	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351746015660	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
351746015661	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746015662	S-adenosylmethionine binding site [chemical binding]; other site
351746015663	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351746015664	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
351746015665	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351746015666	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351746015667	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351746015668	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
351746015669	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351746015670	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351746015671	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351746015672	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
351746015673	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
351746015674	active site residue [active]
351746015675	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
351746015676	active site residue [active]
351746015677	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351746015678	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351746015679	Bacterial transcriptional repressor; Region: TetR; pfam13972
351746015680	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
351746015681	NAD(P) binding site [chemical binding]; other site
351746015682	catalytic residues [active]
351746015683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
351746015684	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
351746015685	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
351746015686	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
351746015687	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
351746015688	active site
351746015689	(T/H)XGH motif; other site
351746015690	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
351746015691	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
351746015692	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
351746015693	DNA binding site [nucleotide binding]
351746015694	catalytic residue [active]
351746015695	H2TH interface [polypeptide binding]; other site
351746015696	putative catalytic residues [active]
351746015697	turnover-facilitating residue; other site
351746015698	intercalation triad [nucleotide binding]; other site
351746015699	8OG recognition residue [nucleotide binding]; other site
351746015700	putative reading head residues; other site
351746015701	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
351746015702	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
351746015703	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
351746015704	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
351746015705	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
351746015706	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
351746015707	putative RNA binding site [nucleotide binding]; other site
351746015708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746015709	S-adenosylmethionine binding site [chemical binding]; other site
351746015710	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
351746015711	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351746015712	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
351746015713	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
351746015714	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
351746015715	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
351746015716	folate binding site [chemical binding]; other site
351746015717	NADP+ binding site [chemical binding]; other site
351746015718	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
351746015719	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
351746015720	G1 box; other site
351746015721	GTP/Mg2+ binding site [chemical binding]; other site
351746015722	G2 box; other site
351746015723	Switch I region; other site
351746015724	G3 box; other site
351746015725	Switch II region; other site
351746015726	G4 box; other site
351746015727	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
351746015728	G5 box; other site
351746015729	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746015730	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351746015731	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
351746015732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015733	dimer interface [polypeptide binding]; other site
351746015734	conserved gate region; other site
351746015735	putative PBP binding loops; other site
351746015736	ABC-ATPase subunit interface; other site
351746015737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015738	dimer interface [polypeptide binding]; other site
351746015739	conserved gate region; other site
351746015740	putative PBP binding loops; other site
351746015741	ABC-ATPase subunit interface; other site
351746015742	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
351746015743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746015744	Walker A/P-loop; other site
351746015745	ATP binding site [chemical binding]; other site
351746015746	Q-loop/lid; other site
351746015747	ABC transporter signature motif; other site
351746015748	Walker B; other site
351746015749	D-loop; other site
351746015750	H-loop/switch region; other site
351746015751	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
351746015752	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746015753	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746015754	dimerization interface [polypeptide binding]; other site
351746015755	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351746015756	Heavy-metal-associated domain; Region: HMA; pfam00403
351746015757	metal-binding site [ion binding]
351746015758	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351746015759	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351746015760	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
351746015761	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
351746015762	DNA binding residues [nucleotide binding]
351746015763	dimer interface [polypeptide binding]; other site
351746015764	putative metal binding site [ion binding]; other site
351746015765	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
351746015766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746015767	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746015768	Walker A motif; other site
351746015769	ATP binding site [chemical binding]; other site
351746015770	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
351746015771	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
351746015772	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
351746015773	substrate binding site [chemical binding]; other site
351746015774	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
351746015775	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
351746015776	substrate binding site [chemical binding]; other site
351746015777	ligand binding site [chemical binding]; other site
351746015778	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
351746015779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746015780	putative substrate translocation pore; other site
351746015781	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
351746015782	active site
351746015783	catalytic residues [active]
351746015784	metal binding site [ion binding]; metal-binding site
351746015785	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
351746015786	CoA-transferase family III; Region: CoA_transf_3; pfam02515
351746015787	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746015788	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746015789	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
351746015790	putative dimerization interface [polypeptide binding]; other site
351746015791	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
351746015792	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
351746015793	active site
351746015794	DNA binding site [nucleotide binding]
351746015795	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
351746015796	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
351746015797	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351746015798	Catalytic site [active]
351746015799	enterobactin receptor protein; Provisional; Region: PRK13483
351746015800	AAA domain; Region: AAA_21; pfam13304
351746015801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
351746015802	Q-loop/lid; other site
351746015803	ABC transporter signature motif; other site
351746015804	Walker B; other site
351746015805	D-loop; other site
351746015806	H-loop/switch region; other site
351746015807	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
351746015808	thymidylate synthase; Reviewed; Region: thyA; PRK01827
351746015809	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
351746015810	dimerization interface [polypeptide binding]; other site
351746015811	active site
351746015812	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
351746015813	active site
351746015814	Int/Topo IB signature motif; other site
351746015815	catalytic residues [active]
351746015816	DNA binding site [nucleotide binding]
351746015817	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
351746015818	DNA binding site [nucleotide binding]
351746015819	active site
351746015820	Int/Topo IB signature motif; other site
351746015821	catalytic residues [active]
351746015822	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
351746015823	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351746015824	active site
351746015825	DNA binding site [nucleotide binding]
351746015826	Int/Topo IB signature motif; other site
351746015827	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
351746015828	dimerization interface [polypeptide binding]; other site
351746015829	active site
351746015830	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
351746015831	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
351746015832	NRDE protein; Region: NRDE; cl01315
351746015833	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
351746015834	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
351746015835	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
351746015836	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
351746015837	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
351746015838	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
351746015839	putative active site [active]
351746015840	Ap4A binding site [chemical binding]; other site
351746015841	nudix motif; other site
351746015842	putative metal binding site [ion binding]; other site
351746015843	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
351746015844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746015845	motif II; other site
351746015846	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
351746015847	threonine dehydratase; Reviewed; Region: PRK09224
351746015848	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
351746015849	tetramer interface [polypeptide binding]; other site
351746015850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746015851	catalytic residue [active]
351746015852	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
351746015853	putative Ile/Val binding site [chemical binding]; other site
351746015854	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
351746015855	putative Ile/Val binding site [chemical binding]; other site
351746015856	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
351746015857	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351746015858	active site
351746015859	dimer interface [polypeptide binding]; other site
351746015860	SdiA-regulated; Region: SdiA-regulated; pfam06977
351746015861	SdiA-regulated; Region: SdiA-regulated; cd09971
351746015862	putative active site [active]
351746015863	SdiA-regulated; Region: SdiA-regulated; pfam06977
351746015864	SdiA-regulated; Region: SdiA-regulated; cd09971
351746015865	putative active site [active]
351746015866	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
351746015867	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
351746015868	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
351746015869	FAD binding domain; Region: FAD_binding_4; pfam01565
351746015870	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
351746015871	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
351746015872	ligand binding site [chemical binding]; other site
351746015873	NAD binding site [chemical binding]; other site
351746015874	tetramer interface [polypeptide binding]; other site
351746015875	catalytic site [active]
351746015876	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
351746015877	L-serine binding site [chemical binding]; other site
351746015878	ACT domain interface; other site
351746015879	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
351746015880	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351746015881	substrate binding pocket [chemical binding]; other site
351746015882	Uncharacterized conserved protein [Function unknown]; Region: COG1683
351746015883	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
351746015884	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
351746015885	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
351746015886	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746015887	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
351746015888	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
351746015889	maltose O-acetyltransferase; Provisional; Region: PRK10092
351746015890	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
351746015891	active site
351746015892	substrate binding site [chemical binding]; other site
351746015893	trimer interface [polypeptide binding]; other site
351746015894	CoA binding site [chemical binding]; other site
351746015895	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
351746015896	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
351746015897	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
351746015898	active site
351746015899	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
351746015900	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
351746015901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351746015902	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351746015903	Walker A motif; other site
351746015904	ATP binding site [chemical binding]; other site
351746015905	Walker B motif; other site
351746015906	arginine finger; other site
351746015907	Serine hydrolase; Region: Ser_hydrolase; pfam06821
351746015908	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
351746015909	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
351746015910	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
351746015911	Walker A/P-loop; other site
351746015912	ATP binding site [chemical binding]; other site
351746015913	Q-loop/lid; other site
351746015914	ABC transporter signature motif; other site
351746015915	Walker B; other site
351746015916	D-loop; other site
351746015917	H-loop/switch region; other site
351746015918	TOBE-like domain; Region: TOBE_3; pfam12857
351746015919	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
351746015920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015921	dimer interface [polypeptide binding]; other site
351746015922	conserved gate region; other site
351746015923	putative PBP binding loops; other site
351746015924	ABC-ATPase subunit interface; other site
351746015925	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
351746015926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015927	dimer interface [polypeptide binding]; other site
351746015928	conserved gate region; other site
351746015929	putative PBP binding loops; other site
351746015930	ABC-ATPase subunit interface; other site
351746015931	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
351746015932	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351746015933	Uncharacterized small protein [Function unknown]; Region: COG5583
351746015934	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
351746015935	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746015936	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746015937	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746015938	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
351746015939	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351746015940	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746015941	Transposase IS200 like; Region: Y1_Tnp; pfam01797
351746015942	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746015943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015944	dimer interface [polypeptide binding]; other site
351746015945	conserved gate region; other site
351746015946	putative PBP binding loops; other site
351746015947	ABC-ATPase subunit interface; other site
351746015948	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351746015949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746015950	dimer interface [polypeptide binding]; other site
351746015951	conserved gate region; other site
351746015952	putative PBP binding loops; other site
351746015953	ABC-ATPase subunit interface; other site
351746015954	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
351746015955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746015956	Walker A/P-loop; other site
351746015957	ATP binding site [chemical binding]; other site
351746015958	Q-loop/lid; other site
351746015959	ABC transporter signature motif; other site
351746015960	Walker B; other site
351746015961	D-loop; other site
351746015962	H-loop/switch region; other site
351746015963	TOBE domain; Region: TOBE_2; pfam08402
351746015964	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746015965	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746015966	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746015967	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746015968	putative aminotransferase; Validated; Region: PRK07480
351746015969	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351746015970	inhibitor-cofactor binding pocket; inhibition site
351746015971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746015972	catalytic residue [active]
351746015973	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746015974	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746015975	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746015976	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746015977	N-acetylglutamate synthase; Validated; Region: PRK05279
351746015978	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
351746015979	putative feedback inhibition sensing region; other site
351746015980	putative nucleotide binding site [chemical binding]; other site
351746015981	putative substrate binding site [chemical binding]; other site
351746015982	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746015983	Coenzyme A binding pocket [chemical binding]; other site
351746015984	acetylornithine deacetylase; Provisional; Region: PRK05111
351746015985	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
351746015986	metal binding site [ion binding]; metal-binding site
351746015987	putative dimer interface [polypeptide binding]; other site
351746015988	Uncharacterized conserved protein [Function unknown]; Region: COG3025
351746015989	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
351746015990	putative active site; other site
351746015991	putative metal binding residues [ion binding]; other site
351746015992	signature motif; other site
351746015993	putative triphosphate binding site [ion binding]; other site
351746015994	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351746015995	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746015996	putative DNA binding site [nucleotide binding]; other site
351746015997	putative Zn2+ binding site [ion binding]; other site
351746015998	AsnC family; Region: AsnC_trans_reg; pfam01037
351746015999	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
351746016000	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
351746016001	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351746016002	Walker A motif; other site
351746016003	ATP binding site [chemical binding]; other site
351746016004	Walker B motif; other site
351746016005	conserverd hypothetical protein; Region: TIGR02448
351746016006	glycine dehydrogenase; Provisional; Region: PRK12566
351746016007	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
351746016008	tetramer interface [polypeptide binding]; other site
351746016009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746016010	catalytic residue [active]
351746016011	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
351746016012	tetramer interface [polypeptide binding]; other site
351746016013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746016014	catalytic residue [active]
351746016015	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
351746016016	lipoyl attachment site [posttranslational modification]; other site
351746016017	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
351746016018	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
351746016019	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
351746016020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746016021	dimer interface [polypeptide binding]; other site
351746016022	conserved gate region; other site
351746016023	putative PBP binding loops; other site
351746016024	ABC-ATPase subunit interface; other site
351746016025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746016026	dimer interface [polypeptide binding]; other site
351746016027	conserved gate region; other site
351746016028	putative PBP binding loops; other site
351746016029	ABC-ATPase subunit interface; other site
351746016030	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
351746016031	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351746016032	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
351746016033	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
351746016034	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
351746016035	active site 2 [active]
351746016036	active site 1 [active]
351746016037	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
351746016038	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
351746016039	proline aminopeptidase P II; Provisional; Region: PRK10879
351746016040	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
351746016041	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
351746016042	active site
351746016043	hypothetical protein; Reviewed; Region: PRK02166
351746016044	TIGR02449 family protein; Region: TIGR02449
351746016045	Cell division protein ZapA; Region: ZapA; pfam05164
351746016046	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
351746016047	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
351746016048	EVE domain; Region: EVE; cl00728
351746016049	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351746016050	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
351746016051	HlyD family secretion protein; Region: HlyD_3; pfam13437
351746016052	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
351746016053	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351746016054	Walker A/P-loop; other site
351746016055	ATP binding site [chemical binding]; other site
351746016056	Q-loop/lid; other site
351746016057	ABC transporter signature motif; other site
351746016058	Walker B; other site
351746016059	D-loop; other site
351746016060	H-loop/switch region; other site
351746016061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351746016062	Walker A/P-loop; other site
351746016063	ATP binding site [chemical binding]; other site
351746016064	Q-loop/lid; other site
351746016065	ABC transporter signature motif; other site
351746016066	Walker B; other site
351746016067	D-loop; other site
351746016068	H-loop/switch region; other site
351746016069	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
351746016070	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
351746016071	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
351746016072	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
351746016073	PemK-like protein; Region: PemK; cl00995
351746016074	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
351746016075	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
351746016076	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
351746016077	NAD(P) binding site [chemical binding]; other site
351746016078	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
351746016079	putative active site pocket [active]
351746016080	dimerization interface [polypeptide binding]; other site
351746016081	putative catalytic residue [active]
351746016082	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
351746016083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351746016084	catalytic loop [active]
351746016085	iron binding site [ion binding]; other site
351746016086	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
351746016087	FAD binding pocket [chemical binding]; other site
351746016088	FAD binding motif [chemical binding]; other site
351746016089	phosphate binding motif [ion binding]; other site
351746016090	beta-alpha-beta structure motif; other site
351746016091	NAD binding pocket [chemical binding]; other site
351746016092	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
351746016093	transcription termination factor Rho; Provisional; Region: rho; PRK09376
351746016094	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
351746016095	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
351746016096	RNA binding site [nucleotide binding]; other site
351746016097	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
351746016098	multimer interface [polypeptide binding]; other site
351746016099	Walker A motif; other site
351746016100	ATP binding site [chemical binding]; other site
351746016101	Walker B motif; other site
351746016102	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
351746016103	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351746016104	catalytic residues [active]
351746016105	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
351746016106	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
351746016107	polyphosphate kinase; Provisional; Region: PRK05443
351746016108	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
351746016109	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
351746016110	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
351746016111	putative active site [active]
351746016112	catalytic site [active]
351746016113	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
351746016114	putative domain interface [polypeptide binding]; other site
351746016115	putative active site [active]
351746016116	catalytic site [active]
351746016117	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
351746016118	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
351746016119	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
351746016120	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
351746016121	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
351746016122	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
351746016123	conserved cys residue [active]
351746016124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
351746016125	adenylate cyclase; Provisional; Region: cyaA; PRK09450
351746016126	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
351746016127	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
351746016128	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
351746016129	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
351746016130	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
351746016131	frataxin-like protein; Provisional; Region: cyaY; PRK00446
351746016132	putative iron binding site [ion binding]; other site
351746016133	diaminopimelate decarboxylase; Region: lysA; TIGR01048
351746016134	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
351746016135	active site
351746016136	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746016137	substrate binding site [chemical binding]; other site
351746016138	catalytic residues [active]
351746016139	dimer interface [polypeptide binding]; other site
351746016140	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
351746016141	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
351746016142	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
351746016143	Protein of unknown function, DUF484; Region: DUF484; cl17449
351746016144	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
351746016145	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351746016146	active site
351746016147	DNA binding site [nucleotide binding]
351746016148	Int/Topo IB signature motif; other site
351746016149	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
351746016150	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351746016151	motif II; other site
351746016152	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
351746016153	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
351746016154	Nitrogen regulatory protein P-II; Region: P-II; smart00938
351746016155	Membrane fusogenic activity; Region: BMFP; pfam04380
351746016156	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
351746016157	putative active site pocket [active]
351746016158	dimerization interface [polypeptide binding]; other site
351746016159	putative catalytic residue [active]
351746016160	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
351746016161	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
351746016162	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
351746016163	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
351746016164	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
351746016165	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
351746016166	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
351746016167	Response regulator receiver domain; Region: Response_reg; pfam00072
351746016168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746016169	active site
351746016170	phosphorylation site [posttranslational modification]
351746016171	intermolecular recognition site; other site
351746016172	dimerization interface [polypeptide binding]; other site
351746016173	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351746016174	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746016175	DNA binding site [nucleotide binding]
351746016176	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
351746016177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746016178	active site
351746016179	phosphorylation site [posttranslational modification]
351746016180	intermolecular recognition site; other site
351746016181	dimerization interface [polypeptide binding]; other site
351746016182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351746016183	DNA binding residues [nucleotide binding]
351746016184	dimerization interface [polypeptide binding]; other site
351746016185	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
351746016186	active site
351746016187	substrate binding site [chemical binding]; other site
351746016188	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
351746016189	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
351746016190	AAA ATPase domain; Region: AAA_16; pfam13191
351746016191	Predicted ATPase [General function prediction only]; Region: COG3899
351746016192	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
351746016193	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
351746016194	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351746016195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746016196	dimer interface [polypeptide binding]; other site
351746016197	phosphorylation site [posttranslational modification]
351746016198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746016199	ATP binding site [chemical binding]; other site
351746016200	Mg2+ binding site [ion binding]; other site
351746016201	G-X-G motif; other site
351746016202	Isochorismatase family; Region: Isochorismatase; pfam00857
351746016203	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
351746016204	catalytic triad [active]
351746016205	dimer interface [polypeptide binding]; other site
351746016206	conserved cis-peptide bond; other site
351746016207	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351746016208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746016209	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746016210	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
351746016211	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
351746016212	conserved cys residue [active]
351746016213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746016214	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351746016215	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
351746016216	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
351746016217	TrkA-N domain; Region: TrkA_N; pfam02254
351746016218	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
351746016219	Isochorismatase family; Region: Isochorismatase; pfam00857
351746016220	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
351746016221	catalytic triad [active]
351746016222	dimer interface [polypeptide binding]; other site
351746016223	conserved cis-peptide bond; other site
351746016224	LysR family transcriptional regulator; Provisional; Region: PRK14997
351746016225	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016226	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
351746016227	putative effector binding pocket; other site
351746016228	putative dimerization interface [polypeptide binding]; other site
351746016229	outer membrane porin, OprD family; Region: OprD; pfam03573
351746016230	Transmembrane secretion effector; Region: MFS_3; pfam05977
351746016231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746016232	putative substrate translocation pore; other site
351746016233	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
351746016234	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
351746016235	active site
351746016236	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
351746016237	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
351746016238	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351746016239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
351746016240	Isochorismatase family; Region: Isochorismatase; pfam00857
351746016241	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
351746016242	catalytic triad [active]
351746016243	dimer interface [polypeptide binding]; other site
351746016244	conserved cis-peptide bond; other site
351746016245	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
351746016246	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351746016247	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
351746016248	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351746016249	ligand binding site [chemical binding]; other site
351746016250	flexible hinge region; other site
351746016251	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746016252	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746016253	aldehyde dehydrogenase family 7 member; Region: PLN02315
351746016254	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
351746016255	tetrameric interface [polypeptide binding]; other site
351746016256	NAD binding site [chemical binding]; other site
351746016257	catalytic residues [active]
351746016258	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746016259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016260	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746016261	dimerization interface [polypeptide binding]; other site
351746016262	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
351746016263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
351746016264	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746016265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016266	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746016267	dimerization interface [polypeptide binding]; other site
351746016268	multidrug efflux protein NorA; Provisional; Region: PRK00187
351746016269	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
351746016270	cation binding site [ion binding]; other site
351746016271	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351746016272	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351746016273	metal binding site [ion binding]; metal-binding site
351746016274	active site
351746016275	I-site; other site
351746016276	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351746016277	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
351746016278	Part of AAA domain; Region: AAA_19; pfam13245
351746016279	Family description; Region: UvrD_C_2; pfam13538
351746016280	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746016281	active site
351746016282	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
351746016283	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
351746016284	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
351746016285	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
351746016286	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351746016287	non-specific DNA binding site [nucleotide binding]; other site
351746016288	salt bridge; other site
351746016289	sequence-specific DNA binding site [nucleotide binding]; other site
351746016290	Cupin domain; Region: Cupin_2; pfam07883
351746016291	alanine racemase; Reviewed; Region: dadX; PRK03646
351746016292	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
351746016293	active site
351746016294	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351746016295	substrate binding site [chemical binding]; other site
351746016296	catalytic residues [active]
351746016297	dimer interface [polypeptide binding]; other site
351746016298	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
351746016299	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
351746016300	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351746016301	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
351746016302	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351746016303	putative DNA binding site [nucleotide binding]; other site
351746016304	putative Zn2+ binding site [ion binding]; other site
351746016305	AsnC family; Region: AsnC_trans_reg; pfam01037
351746016306	Flagellin N-methylase; Region: FliB; pfam03692
351746016307	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
351746016308	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
351746016309	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
351746016310	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746016311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746016312	DNA-binding site [nucleotide binding]; DNA binding site
351746016313	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746016314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746016315	homodimer interface [polypeptide binding]; other site
351746016316	catalytic residue [active]
351746016317	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
351746016318	PLD-like domain; Region: PLDc_2; pfam13091
351746016319	putative active site [active]
351746016320	catalytic site [active]
351746016321	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
351746016322	PLD-like domain; Region: PLDc_2; pfam13091
351746016323	putative active site [active]
351746016324	catalytic site [active]
351746016325	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
351746016326	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
351746016327	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
351746016328	NAD(P) binding site [chemical binding]; other site
351746016329	catalytic residues [active]
351746016330	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
351746016331	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
351746016332	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
351746016333	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
351746016334	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
351746016335	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
351746016336	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
351746016337	peptide binding site [polypeptide binding]; other site
351746016338	hypothetical protein; Reviewed; Region: PRK00024
351746016339	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
351746016340	MPN+ (JAMM) motif; other site
351746016341	Zinc-binding site [ion binding]; other site
351746016342	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
351746016343	Flavoprotein; Region: Flavoprotein; pfam02441
351746016344	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
351746016345	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
351746016346	trimer interface [polypeptide binding]; other site
351746016347	active site
351746016348	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
351746016349	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
351746016350	active site
351746016351	substrate binding site [chemical binding]; other site
351746016352	metal binding site [ion binding]; metal-binding site
351746016353	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
351746016354	feedback inhibition sensing region; other site
351746016355	homohexameric interface [polypeptide binding]; other site
351746016356	nucleotide binding site [chemical binding]; other site
351746016357	N-acetyl-L-glutamate binding site [chemical binding]; other site
351746016358	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351746016359	active site
351746016360	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
351746016361	putative active site [active]
351746016362	putative catalytic site [active]
351746016363	putative DNA binding site [nucleotide binding]; other site
351746016364	putative phosphate binding site [ion binding]; other site
351746016365	metal binding site A [ion binding]; metal-binding site
351746016366	putative AP binding site [nucleotide binding]; other site
351746016367	putative metal binding site B [ion binding]; other site
351746016368	Tic20-like protein; Region: Tic20; pfam09685
351746016369	ribonuclease PH; Reviewed; Region: rph; PRK00173
351746016370	Ribonuclease PH; Region: RNase_PH_bact; cd11362
351746016371	hexamer interface [polypeptide binding]; other site
351746016372	active site
351746016373	hypothetical protein; Provisional; Region: PRK11820
351746016374	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
351746016375	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
351746016376	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
351746016377	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
351746016378	catalytic site [active]
351746016379	G-X2-G-X-G-K; other site
351746016380	similar to hypothetical protein
351746016381	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
351746016382	Peptidase C26; Region: Peptidase_C26; pfam07722
351746016383	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
351746016384	catalytic triad [active]
351746016385	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351746016386	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351746016387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746016388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
351746016390	dimerization interface [polypeptide binding]; other site
351746016391	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
351746016392	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
351746016393	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351746016394	Zn2+ binding site [ion binding]; other site
351746016395	Mg2+ binding site [ion binding]; other site
351746016396	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
351746016397	synthetase active site [active]
351746016398	NTP binding site [chemical binding]; other site
351746016399	metal binding site [ion binding]; metal-binding site
351746016400	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
351746016401	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
351746016402	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351746016403	homotrimer interaction site [polypeptide binding]; other site
351746016404	putative active site [active]
351746016405	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
351746016406	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
351746016407	putative NAD(P) binding site [chemical binding]; other site
351746016408	tonB-system energizer ExbB; Region: exbB; TIGR02797
351746016409	biopolymer transport protein ExbD; Provisional; Region: PRK11267
351746016410	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
351746016411	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
351746016412	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
351746016413	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
351746016414	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016415	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
351746016416	dimerization interface [polypeptide binding]; other site
351746016417	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
351746016418	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
351746016419	generic binding surface II; other site
351746016420	ssDNA binding site; other site
351746016421	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351746016422	ATP binding site [chemical binding]; other site
351746016423	putative Mg++ binding site [ion binding]; other site
351746016424	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351746016425	nucleotide binding region [chemical binding]; other site
351746016426	ATP-binding site [chemical binding]; other site
351746016427	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
351746016428	putative deacylase active site [active]
351746016429	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
351746016430	SCP-2 sterol transfer family; Region: SCP2; pfam02036
351746016431	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351746016432	IHF dimer interface [polypeptide binding]; other site
351746016433	IHF - DNA interface [nucleotide binding]; other site
351746016434	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
351746016435	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746016436	Rubredoxin [Energy production and conversion]; Region: COG1773
351746016437	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
351746016438	iron binding site [ion binding]; other site
351746016439	Chorismate lyase; Region: Chor_lyase; cl01230
351746016440	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
351746016441	UbiA prenyltransferase family; Region: UbiA; pfam01040
351746016442	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
351746016443	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
351746016444	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
351746016445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746016446	active site
351746016447	phosphorylation site [posttranslational modification]
351746016448	intermolecular recognition site; other site
351746016449	dimerization interface [polypeptide binding]; other site
351746016450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746016451	DNA binding site [nucleotide binding]
351746016452	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
351746016453	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351746016454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351746016455	putative active site [active]
351746016456	heme pocket [chemical binding]; other site
351746016457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746016458	dimer interface [polypeptide binding]; other site
351746016459	phosphorylation site [posttranslational modification]
351746016460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746016461	ATP binding site [chemical binding]; other site
351746016462	Mg2+ binding site [ion binding]; other site
351746016463	G-X-G motif; other site
351746016464	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
351746016465	Domain of unknown function DUF21; Region: DUF21; pfam01595
351746016466	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
351746016467	Transporter associated domain; Region: CorC_HlyC; smart01091
351746016468	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
351746016469	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351746016470	Peptidase family M23; Region: Peptidase_M23; pfam01551
351746016471	Response regulator receiver domain; Region: Response_reg; pfam00072
351746016472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746016473	active site
351746016474	phosphorylation site [posttranslational modification]
351746016475	intermolecular recognition site; other site
351746016476	dimerization interface [polypeptide binding]; other site
351746016477	transcriptional regulator PhoU; Provisional; Region: PRK11115
351746016478	PhoU domain; Region: PhoU; pfam01895
351746016479	PhoU domain; Region: PhoU; pfam01895
351746016480	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
351746016481	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
351746016482	Walker A/P-loop; other site
351746016483	ATP binding site [chemical binding]; other site
351746016484	Q-loop/lid; other site
351746016485	ABC transporter signature motif; other site
351746016486	Walker B; other site
351746016487	D-loop; other site
351746016488	H-loop/switch region; other site
351746016489	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
351746016490	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
351746016491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746016492	dimer interface [polypeptide binding]; other site
351746016493	conserved gate region; other site
351746016494	putative PBP binding loops; other site
351746016495	ABC-ATPase subunit interface; other site
351746016496	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
351746016497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351746016498	dimer interface [polypeptide binding]; other site
351746016499	conserved gate region; other site
351746016500	putative PBP binding loops; other site
351746016501	ABC-ATPase subunit interface; other site
351746016502	phosphate binding protein; Region: ptsS_2; TIGR02136
351746016503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746016504	metabolite-proton symporter; Region: 2A0106; TIGR00883
351746016505	putative substrate translocation pore; other site
351746016506	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
351746016507	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
351746016508	active site
351746016509	phosphate binding residues; other site
351746016510	catalytic residues [active]
351746016511	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
351746016512	Predicted membrane protein [Function unknown]; Region: COG2261
351746016513	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
351746016514	ATP-grasp domain; Region: ATP-grasp; pfam02222
351746016515	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
351746016516	cell density-dependent motility repressor; Provisional; Region: PRK10082
351746016517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016518	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
351746016519	dimerization interface [polypeptide binding]; other site
351746016520	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
351746016521	Aspartase; Region: Aspartase; cd01357
351746016522	active sites [active]
351746016523	tetramer interface [polypeptide binding]; other site
351746016524	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
351746016525	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351746016526	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
351746016527	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
351746016528	active site
351746016529	Zn binding site [ion binding]; other site
351746016530	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
351746016531	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351746016532	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351746016533	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351746016534	DNA-binding site [nucleotide binding]; DNA binding site
351746016535	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351746016536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351746016537	homodimer interface [polypeptide binding]; other site
351746016538	catalytic residue [active]
351746016539	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
351746016540	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
351746016541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351746016542	Coenzyme A binding pocket [chemical binding]; other site
351746016543	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
351746016544	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
351746016545	pyruvate carboxylase subunit B; Validated; Region: PRK09282
351746016546	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
351746016547	active site
351746016548	catalytic residues [active]
351746016549	metal binding site [ion binding]; metal-binding site
351746016550	homodimer binding site [polypeptide binding]; other site
351746016551	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351746016552	carboxyltransferase (CT) interaction site; other site
351746016553	biotinylation site [posttranslational modification]; other site
351746016554	pyruvate carboxylase subunit A; Validated; Region: PRK07178
351746016555	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351746016556	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
351746016557	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
351746016558	Transcriptional regulator [Transcription]; Region: LysR; COG0583
351746016559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016560	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
351746016561	putative dimerization interface [polypeptide binding]; other site
351746016562	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
351746016563	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
351746016564	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
351746016565	putative active site [active]
351746016566	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
351746016567	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
351746016568	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
351746016569	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
351746016570	Part of AAA domain; Region: AAA_19; pfam13245
351746016571	Family description; Region: UvrD_C_2; pfam13538
351746016572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
351746016573	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
351746016574	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
351746016575	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
351746016576	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
351746016577	pyridoxamine kinase; Validated; Region: PRK05756
351746016578	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
351746016579	pyridoxal binding site [chemical binding]; other site
351746016580	dimer interface [polypeptide binding]; other site
351746016581	ATP binding site [chemical binding]; other site
351746016582	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
351746016583	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
351746016584	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
351746016585	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
351746016586	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
351746016587	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
351746016588	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
351746016589	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
351746016590	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
351746016591	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
351746016592	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
351746016593	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
351746016594	putative active site [active]
351746016595	catalytic site [active]
351746016596	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
351746016597	putative active site [active]
351746016598	catalytic site [active]
351746016599	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
351746016600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746016601	S-adenosylmethionine binding site [chemical binding]; other site
351746016602	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
351746016603	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
351746016604	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351746016605	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351746016606	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
351746016607	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
351746016608	PYR/PP interface [polypeptide binding]; other site
351746016609	dimer interface [polypeptide binding]; other site
351746016610	TPP binding site [chemical binding]; other site
351746016611	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351746016612	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
351746016613	TPP-binding site [chemical binding]; other site
351746016614	dimer interface [polypeptide binding]; other site
351746016615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746016616	putative substrate translocation pore; other site
351746016617	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
351746016618	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351746016619	NAD(P) binding site [chemical binding]; other site
351746016620	active site
351746016621	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
351746016622	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351746016623	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
351746016624	dimerization interface [polypeptide binding]; other site
351746016625	substrate binding pocket [chemical binding]; other site
351746016626	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351746016627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746016628	S-adenosylmethionine binding site [chemical binding]; other site
351746016629	outer membrane porin, OprD family; Region: OprD; pfam03573
351746016630	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
351746016631	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
351746016632	inhibitor site; inhibition site
351746016633	active site
351746016634	dimer interface [polypeptide binding]; other site
351746016635	catalytic residue [active]
351746016636	benzoate transport; Region: 2A0115; TIGR00895
351746016637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746016638	putative substrate translocation pore; other site
351746016639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351746016640	osmolarity response regulator; Provisional; Region: ompR; PRK09468
351746016641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351746016642	active site
351746016643	phosphorylation site [posttranslational modification]
351746016644	intermolecular recognition site; other site
351746016645	dimerization interface [polypeptide binding]; other site
351746016646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351746016647	DNA binding site [nucleotide binding]
351746016648	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
351746016649	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351746016650	dimerization interface [polypeptide binding]; other site
351746016651	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351746016652	dimer interface [polypeptide binding]; other site
351746016653	phosphorylation site [posttranslational modification]
351746016654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351746016655	ATP binding site [chemical binding]; other site
351746016656	Mg2+ binding site [ion binding]; other site
351746016657	G-X-G motif; other site
351746016658	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351746016659	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351746016660	Bacterial transcriptional regulator; Region: IclR; pfam01614
351746016661	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
351746016662	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
351746016663	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
351746016664	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
351746016665	glutaminase active site [active]
351746016666	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
351746016667	dimer interface [polypeptide binding]; other site
351746016668	active site
351746016669	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
351746016670	dimer interface [polypeptide binding]; other site
351746016671	active site
351746016672	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
351746016673	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
351746016674	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351746016675	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
351746016676	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
351746016677	Substrate binding site; other site
351746016678	Mg++ binding site; other site
351746016679	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
351746016680	active site
351746016681	substrate binding site [chemical binding]; other site
351746016682	CoA binding site [chemical binding]; other site
351746016683	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
351746016684	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
351746016685	gamma subunit interface [polypeptide binding]; other site
351746016686	epsilon subunit interface [polypeptide binding]; other site
351746016687	LBP interface [polypeptide binding]; other site
351746016688	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
351746016689	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
351746016690	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
351746016691	alpha subunit interaction interface [polypeptide binding]; other site
351746016692	Walker A motif; other site
351746016693	ATP binding site [chemical binding]; other site
351746016694	Walker B motif; other site
351746016695	inhibitor binding site; inhibition site
351746016696	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
351746016697	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
351746016698	core domain interface [polypeptide binding]; other site
351746016699	delta subunit interface [polypeptide binding]; other site
351746016700	epsilon subunit interface [polypeptide binding]; other site
351746016701	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
351746016702	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
351746016703	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
351746016704	beta subunit interaction interface [polypeptide binding]; other site
351746016705	Walker A motif; other site
351746016706	ATP binding site [chemical binding]; other site
351746016707	Walker B motif; other site
351746016708	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
351746016709	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
351746016710	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
351746016711	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
351746016712	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
351746016713	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
351746016714	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
351746016715	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
351746016716	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
351746016717	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
351746016718	ParB-like nuclease domain; Region: ParBc; pfam02195
351746016719	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
351746016720	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
351746016721	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351746016722	Magnesium ion binding site [ion binding]; other site
351746016723	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
351746016724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351746016725	S-adenosylmethionine binding site [chemical binding]; other site
351746016726	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
351746016727	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
351746016728	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
351746016729	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
351746016730	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
351746016731	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
351746016732	trmE is a tRNA modification GTPase; Region: trmE; cd04164
351746016733	G1 box; other site
351746016734	GTP/Mg2+ binding site [chemical binding]; other site
351746016735	Switch I region; other site
351746016736	G2 box; other site
351746016737	Switch II region; other site
351746016738	G3 box; other site
351746016739	G4 box; other site
351746016740	G5 box; other site
351746016741	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
351746016742	membrane protein insertase; Provisional; Region: PRK01318
351746016743	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
351746016744	hypothetical protein; Provisional; Region: PRK14371
351746016745	ribonuclease P; Reviewed; Region: rnpA; PRK00396