-- dump date   	20140620_010410
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
76869000001	ribonuclease P; Reviewed; Region: rnpA; PRK00396
76869000002	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
76869000003	DnaA N-terminal domain; Region: DnaA_N; pfam11638
76869000004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869000005	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869000006	Walker A motif; other site
76869000007	ATP binding site [chemical binding]; other site
76869000008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
76869000009	Walker B motif; other site
76869000010	arginine finger; other site
76869000011	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
76869000012	DnaA box-binding interface [nucleotide binding]; other site
76869000013	DNA polymerase III subunit beta; Validated; Region: PRK05643
76869000014	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
76869000015	putative DNA binding surface [nucleotide binding]; other site
76869000016	dimer interface [polypeptide binding]; other site
76869000017	beta-clamp/clamp loader binding surface; other site
76869000018	beta-clamp/translesion DNA polymerase binding surface; other site
76869000019	recombination protein F; Reviewed; Region: recF; PRK00064
76869000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869000021	Walker A/P-loop; other site
76869000022	ATP binding site [chemical binding]; other site
76869000023	Q-loop/lid; other site
76869000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869000025	ABC transporter signature motif; other site
76869000026	Walker B; other site
76869000027	D-loop; other site
76869000028	H-loop/switch region; other site
76869000029	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
76869000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000031	Mg2+ binding site [ion binding]; other site
76869000032	G-X-G motif; other site
76869000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
76869000034	anchoring element; other site
76869000035	dimer interface [polypeptide binding]; other site
76869000036	ATP binding site [chemical binding]; other site
76869000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
76869000038	active site
76869000039	putative metal-binding site [ion binding]; other site
76869000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
76869000041	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
76869000042	Integrase core domain; Region: rve; pfam00665
76869000043	Bacterial TniB protein; Region: TniB; pfam05621
76869000044	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869000045	TniQ; Region: TniQ; pfam06527
76869000046	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869000047	Predicted metal-binding protein [General function prediction only]; Region: COG3019
76869000048	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869000049	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
76869000050	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
76869000051	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
76869000052	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
76869000053	Multicopper oxidase; Region: Cu-oxidase; pfam00394
76869000054	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
76869000055	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
76869000056	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
76869000057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000058	active site
76869000059	phosphorylation site [posttranslational modification]
76869000060	intermolecular recognition site; other site
76869000061	dimerization interface [polypeptide binding]; other site
76869000062	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869000063	DNA binding site [nucleotide binding]
76869000064	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
76869000065	HAMP domain; Region: HAMP; pfam00672
76869000066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869000067	dimer interface [polypeptide binding]; other site
76869000068	phosphorylation site [posttranslational modification]
76869000069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000070	ATP binding site [chemical binding]; other site
76869000071	Mg2+ binding site [ion binding]; other site
76869000072	G-X-G motif; other site
76869000073	Outer membrane efflux protein; Region: OEP; pfam02321
76869000074	Outer membrane efflux protein; Region: OEP; pfam02321
76869000075	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
76869000076	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869000077	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
76869000078	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
76869000079	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
76869000080	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
76869000081	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
76869000082	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
76869000083	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869000084	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869000085	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869000086	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869000087	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
76869000088	metal-binding site [ion binding]
76869000089	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
76869000090	YHS domain; Region: YHS; pfam04945
76869000091	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
76869000092	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869000093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869000094	motif II; other site
76869000095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
76869000096	ATP binding site [chemical binding]; other site
76869000097	Mg2+ binding site [ion binding]; other site
76869000098	G-X-G motif; other site
76869000099	putative metal dependent hydrolase; Provisional; Region: PRK11598
76869000100	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
76869000101	Sulfatase; Region: Sulfatase; pfam00884
76869000102	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
76869000103	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
76869000104	hypothetical protein; Provisional; Region: PRK09272
76869000105	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869000106	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
76869000107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000108	active site
76869000109	phosphorylation site [posttranslational modification]
76869000110	intermolecular recognition site; other site
76869000111	dimerization interface [polypeptide binding]; other site
76869000112	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869000113	DNA binding site [nucleotide binding]
76869000114	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
76869000115	HAMP domain; Region: HAMP; pfam00672
76869000116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869000117	dimer interface [polypeptide binding]; other site
76869000118	phosphorylation site [posttranslational modification]
76869000119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000120	ATP binding site [chemical binding]; other site
76869000121	Mg2+ binding site [ion binding]; other site
76869000122	G-X-G motif; other site
76869000123	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
76869000124	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
76869000125	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
76869000126	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
76869000127	Ligand binding site; other site
76869000128	Putative Catalytic site; other site
76869000129	DXD motif; other site
76869000130	Membrane protein of unknown function; Region: DUF360; pfam04020
76869000131	Predicted membrane protein [Function unknown]; Region: COG2246
76869000132	GtrA-like protein; Region: GtrA; pfam04138
76869000133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869000134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869000135	LysR substrate binding domain; Region: LysR_substrate; pfam03466
76869000136	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
76869000137	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
76869000138	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
76869000139	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869000140	Soluble P-type ATPase [General function prediction only]; Region: COG4087
76869000141	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869000142	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
76869000143	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
76869000144	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869000145	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
76869000146	outer membrane porin, OprD family; Region: OprD; pfam03573
76869000147	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
76869000148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000149	active site
76869000150	phosphorylation site [posttranslational modification]
76869000151	intermolecular recognition site; other site
76869000152	dimerization interface [polypeptide binding]; other site
76869000153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869000154	DNA binding site [nucleotide binding]
76869000155	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
76869000156	PAS fold; Region: PAS_4; pfam08448
76869000157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869000158	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869000159	Walker A motif; other site
76869000160	ATP binding site [chemical binding]; other site
76869000161	Walker B motif; other site
76869000162	arginine finger; other site
76869000163	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869000164	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
76869000165	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
76869000166	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869000167	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869000168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869000169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869000170	dimerization interface [polypeptide binding]; other site
76869000171	choline dehydrogenase; Validated; Region: PRK02106
76869000172	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869000173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869000174	putative substrate translocation pore; other site
76869000175	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
76869000176	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
76869000177	putative acyl-acceptor binding pocket; other site
76869000178	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
76869000179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869000180	active site
76869000181	motif I; other site
76869000182	motif II; other site
76869000183	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
76869000184	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
76869000185	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
76869000186	dimer interface [polypeptide binding]; other site
76869000187	motif 1; other site
76869000188	active site
76869000189	motif 2; other site
76869000190	motif 3; other site
76869000191	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
76869000192	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
76869000193	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
76869000194	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
76869000195	putative acyl-acceptor binding pocket; other site
76869000196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869000197	TPR motif; other site
76869000198	TPR repeat; Region: TPR_11; pfam13414
76869000199	binding surface
76869000200	K+ potassium transporter; Region: K_trans; cl15781
76869000201	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
76869000202	TrkA-N domain; Region: TrkA_N; pfam02254
76869000203	TrkA-C domain; Region: TrkA_C; pfam02080
76869000204	TrkA-N domain; Region: TrkA_N; pfam02254
76869000205	TrkA-C domain; Region: TrkA_C; pfam02080
76869000206	16S rRNA methyltransferase B; Provisional; Region: PRK10901
76869000207	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
76869000208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869000209	S-adenosylmethionine binding site [chemical binding]; other site
76869000210	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
76869000211	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
76869000212	putative active site [active]
76869000213	substrate binding site [chemical binding]; other site
76869000214	putative cosubstrate binding site; other site
76869000215	catalytic site [active]
76869000216	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
76869000217	substrate binding site [chemical binding]; other site
76869000218	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
76869000219	active site
76869000220	catalytic residues [active]
76869000221	metal binding site [ion binding]; metal-binding site
76869000222	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
76869000223	DNA protecting protein DprA; Region: dprA; TIGR00732
76869000224	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
76869000225	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
76869000226	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
76869000227	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
76869000228	NADP binding site [chemical binding]; other site
76869000229	dimer interface [polypeptide binding]; other site
76869000230	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
76869000231	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
76869000232	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
76869000233	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
76869000234	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
76869000235	shikimate binding site; other site
76869000236	NAD(P) binding site [chemical binding]; other site
76869000237	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
76869000238	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
76869000239	Sulfate transporter family; Region: Sulfate_transp; pfam00916
76869000240	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
76869000241	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
76869000242	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
76869000243	Sulfatase; Region: Sulfatase; cl17466
76869000244	choline-sulfatase; Region: chol_sulfatase; TIGR03417
76869000245	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
76869000246	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
76869000247	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869000248	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
76869000249	dimerization interface [polypeptide binding]; other site
76869000250	substrate binding pocket [chemical binding]; other site
76869000251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869000252	NADH(P)-binding; Region: NAD_binding_10; pfam13460
76869000253	NAD(P) binding site [chemical binding]; other site
76869000254	active site
76869000255	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
76869000256	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
76869000257	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
76869000258	substrate binding site [chemical binding]; other site
76869000259	active site
76869000260	catalytic residues [active]
76869000261	heterodimer interface [polypeptide binding]; other site
76869000262	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
76869000263	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
76869000264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869000265	catalytic residue [active]
76869000266	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869000267	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869000268	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869000269	dimerization interface [polypeptide binding]; other site
76869000270	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
76869000271	Dodecin; Region: Dodecin; pfam07311
76869000272	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
76869000273	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
76869000274	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869000275	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
76869000276	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
76869000277	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
76869000278	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
76869000279	Eukaryotic phosphomannomutase; Region: PMM; cl17107
76869000280	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
76869000281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869000282	motif II; other site
76869000283	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
76869000284	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
76869000285	trimer interface [polypeptide binding]; other site
76869000286	putative metal binding site [ion binding]; other site
76869000287	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
76869000288	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
76869000289	active site
76869000290	Zn binding site [ion binding]; other site
76869000291	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
76869000292	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
76869000293	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869000294	FeS/SAM binding site; other site
76869000295	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
76869000296	active site clefts [active]
76869000297	zinc binding site [ion binding]; other site
76869000298	dimer interface [polypeptide binding]; other site
76869000299	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
76869000300	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
76869000301	Sulfate transporter family; Region: Sulfate_transp; pfam00916
76869000302	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
76869000303	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
76869000304	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
76869000305	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
76869000306	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869000307	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869000308	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
76869000309	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
76869000310	Subunit I/III interface [polypeptide binding]; other site
76869000311	D-pathway; other site
76869000312	Subunit I/VIIc interface [polypeptide binding]; other site
76869000313	Subunit I/IV interface [polypeptide binding]; other site
76869000314	Subunit I/II interface [polypeptide binding]; other site
76869000315	Low-spin heme (heme a) binding site [chemical binding]; other site
76869000316	Subunit I/VIIa interface [polypeptide binding]; other site
76869000317	Subunit I/VIa interface [polypeptide binding]; other site
76869000318	Dimer interface; other site
76869000319	Putative water exit pathway; other site
76869000320	Binuclear center (heme a3/CuB) [ion binding]; other site
76869000321	K-pathway; other site
76869000322	Subunit I/Vb interface [polypeptide binding]; other site
76869000323	Putative proton exit pathway; other site
76869000324	Subunit I/VIb interface; other site
76869000325	Subunit I/VIc interface [polypeptide binding]; other site
76869000326	Electron transfer pathway; other site
76869000327	Subunit I/VIIIb interface [polypeptide binding]; other site
76869000328	Subunit I/VIIb interface [polypeptide binding]; other site
76869000329	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
76869000330	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
76869000331	Subunit III/VIIa interface [polypeptide binding]; other site
76869000332	Phospholipid binding site [chemical binding]; other site
76869000333	Subunit I/III interface [polypeptide binding]; other site
76869000334	Subunit III/VIb interface [polypeptide binding]; other site
76869000335	Subunit III/VIa interface; other site
76869000336	Subunit III/Vb interface [polypeptide binding]; other site
76869000337	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
76869000338	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
76869000339	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
76869000340	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
76869000341	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
76869000342	UbiA prenyltransferase family; Region: UbiA; pfam01040
76869000343	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
76869000344	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869000345	Cu(I) binding site [ion binding]; other site
76869000346	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
76869000347	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
76869000348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000349	dimer interface [polypeptide binding]; other site
76869000350	conserved gate region; other site
76869000351	ABC-ATPase subunit interface; other site
76869000352	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
76869000353	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
76869000354	Walker A/P-loop; other site
76869000355	ATP binding site [chemical binding]; other site
76869000356	Q-loop/lid; other site
76869000357	ABC transporter signature motif; other site
76869000358	Walker B; other site
76869000359	D-loop; other site
76869000360	H-loop/switch region; other site
76869000361	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
76869000362	hydroperoxidase II; Provisional; Region: katE; PRK11249
76869000363	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
76869000364	tetramer interface [polypeptide binding]; other site
76869000365	heme binding pocket [chemical binding]; other site
76869000366	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
76869000367	domain interactions; other site
76869000368	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
76869000369	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
76869000370	ABC-ATPase subunit  interface; other site
76869000371	dimer interface [polypeptide binding]; other site
76869000372	putative PBP binding regions; other site
76869000373	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
76869000374	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
76869000375	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
76869000376	metal binding site 2 [ion binding]; metal-binding site
76869000377	putative DNA binding helix; other site
76869000378	metal binding site 1 [ion binding]; metal-binding site
76869000379	dimer interface [polypeptide binding]; other site
76869000380	structural Zn2+ binding site [ion binding]; other site
76869000381	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
76869000382	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
76869000383	metal binding site [ion binding]; metal-binding site
76869000384	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
76869000385	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
76869000386	putative active site [active]
76869000387	putative substrate binding site [chemical binding]; other site
76869000388	ATP binding site [chemical binding]; other site
76869000389	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
76869000390	DNA polymerase I; Provisional; Region: PRK05755
76869000391	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
76869000392	active site
76869000393	metal binding site 1 [ion binding]; metal-binding site
76869000394	putative 5' ssDNA interaction site; other site
76869000395	metal binding site 3; metal-binding site
76869000396	metal binding site 2 [ion binding]; metal-binding site
76869000397	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
76869000398	putative DNA binding site [nucleotide binding]; other site
76869000399	putative metal binding site [ion binding]; other site
76869000400	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
76869000401	active site
76869000402	catalytic site [active]
76869000403	substrate binding site [chemical binding]; other site
76869000404	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
76869000405	active site
76869000406	DNA binding site [nucleotide binding]
76869000407	catalytic site [active]
76869000408	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
76869000409	G1 box; other site
76869000410	GTP/Mg2+ binding site [chemical binding]; other site
76869000411	Switch I region; other site
76869000412	G2 box; other site
76869000413	G3 box; other site
76869000414	Switch II region; other site
76869000415	G4 box; other site
76869000416	G5 box; other site
76869000417	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
76869000418	Cytochrome c553 [Energy production and conversion]; Region: COG2863
76869000419	Cytochrome c; Region: Cytochrom_C; cl11414
76869000420	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
76869000421	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
76869000422	catalytic residues [active]
76869000423	hinge region; other site
76869000424	alpha helical domain; other site
76869000425	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
76869000426	putative catalytic site [active]
76869000427	putative metal binding site [ion binding]; other site
76869000428	putative phosphate binding site [ion binding]; other site
76869000429	putative catalytic site [active]
76869000430	putative phosphate binding site [ion binding]; other site
76869000431	putative metal binding site [ion binding]; other site
76869000432	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869000433	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869000434	metal binding site [ion binding]; metal-binding site
76869000435	active site
76869000436	I-site; other site
76869000437	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
76869000438	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
76869000439	amidase catalytic site [active]
76869000440	Zn binding residues [ion binding]; other site
76869000441	substrate binding site [chemical binding]; other site
76869000442	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
76869000443	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
76869000444	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
76869000445	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869000446	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869000447	dimerization interface [polypeptide binding]; other site
76869000448	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
76869000449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869000450	dimer interface [polypeptide binding]; other site
76869000451	phosphorylation site [posttranslational modification]
76869000452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000453	ATP binding site [chemical binding]; other site
76869000454	Mg2+ binding site [ion binding]; other site
76869000455	G-X-G motif; other site
76869000456	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869000457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000458	active site
76869000459	phosphorylation site [posttranslational modification]
76869000460	intermolecular recognition site; other site
76869000461	dimerization interface [polypeptide binding]; other site
76869000462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869000463	Walker A motif; other site
76869000464	ATP binding site [chemical binding]; other site
76869000465	Walker B motif; other site
76869000466	arginine finger; other site
76869000467	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869000468	BON domain; Region: BON; pfam04972
76869000469	BON domain; Region: BON; pfam04972
76869000470	BON domain; Region: BON; pfam04972
76869000471	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
76869000472	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
76869000473	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
76869000474	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
76869000475	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
76869000476	Protein of unknown function (DUF330); Region: DUF330; cl01135
76869000477	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
76869000478	mce related protein; Region: MCE; pfam02470
76869000479	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
76869000480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869000481	Walker A/P-loop; other site
76869000482	ATP binding site [chemical binding]; other site
76869000483	Q-loop/lid; other site
76869000484	ABC transporter signature motif; other site
76869000485	Walker B; other site
76869000486	D-loop; other site
76869000487	H-loop/switch region; other site
76869000488	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
76869000489	Permease; Region: Permease; pfam02405
76869000490	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
76869000491	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
76869000492	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
76869000493	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869000494	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
76869000495	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
76869000496	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
76869000497	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
76869000498	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
76869000499	Citrate transporter; Region: CitMHS; pfam03600
76869000500	Uncharacterized conserved protein [Function unknown]; Region: COG3791
76869000501	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
76869000502	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
76869000503	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
76869000504	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
76869000505	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
76869000506	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
76869000507	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
76869000508	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
76869000509	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
76869000510	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
76869000511	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
76869000512	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
76869000513	ligand binding site [chemical binding]; other site
76869000514	homodimer interface [polypeptide binding]; other site
76869000515	NAD(P) binding site [chemical binding]; other site
76869000516	trimer interface B [polypeptide binding]; other site
76869000517	trimer interface A [polypeptide binding]; other site
76869000518	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869000519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869000520	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
76869000521	dimerization interface [polypeptide binding]; other site
76869000522	substrate binding pocket [chemical binding]; other site
76869000523	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
76869000524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869000525	FAD binding site [chemical binding]; other site
76869000526	substrate binding pocket [chemical binding]; other site
76869000527	catalytic base [active]
76869000528	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
76869000529	CoA-transferase family III; Region: CoA_transf_3; pfam02515
76869000530	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869000531	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
76869000532	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869000533	N-terminal plug; other site
76869000534	ligand-binding site [chemical binding]; other site
76869000535	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869000536	FecR protein; Region: FecR; pfam04773
76869000537	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869000538	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869000539	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869000540	DNA binding residues [nucleotide binding]
76869000541	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
76869000542	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869000543	DNA-binding site [nucleotide binding]; DNA binding site
76869000544	FCD domain; Region: FCD; pfam07729
76869000545	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
76869000546	biofilm formation regulator HmsP; Provisional; Region: PRK11829
76869000547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869000548	dimerization interface [polypeptide binding]; other site
76869000549	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869000550	metal binding site [ion binding]; metal-binding site
76869000551	active site
76869000552	I-site; other site
76869000553	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869000554	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
76869000555	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869000556	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869000557	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
76869000558	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
76869000559	putative active site [active]
76869000560	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869000561	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
76869000562	Walker A/P-loop; other site
76869000563	ATP binding site [chemical binding]; other site
76869000564	Q-loop/lid; other site
76869000565	ABC transporter signature motif; other site
76869000566	Walker B; other site
76869000567	D-loop; other site
76869000568	H-loop/switch region; other site
76869000569	Calx-beta domain; Region: Calx-beta; cl02522
76869000570	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
76869000571	metal ion-dependent adhesion site (MIDAS); other site
76869000572	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
76869000573	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
76869000574	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869000575	NMT1-like family; Region: NMT1_2; pfam13379
76869000576	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
76869000577	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869000578	Walker A/P-loop; other site
76869000579	ATP binding site [chemical binding]; other site
76869000580	Q-loop/lid; other site
76869000581	ABC transporter signature motif; other site
76869000582	Walker B; other site
76869000583	D-loop; other site
76869000584	H-loop/switch region; other site
76869000585	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869000586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000587	putative PBP binding loops; other site
76869000588	ABC-ATPase subunit interface; other site
76869000589	Protein of unknown function (DUF796); Region: DUF796; pfam05638
76869000590	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
76869000591	WYL domain; Region: WYL; pfam13280
76869000592	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
76869000593	Sel1-like repeats; Region: SEL1; smart00671
76869000594	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869000595	MarR family; Region: MarR_2; cl17246
76869000596	Fusaric acid resistance protein family; Region: FUSC; pfam04632
76869000597	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
76869000598	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
76869000599	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
76869000600	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869000601	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869000602	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
76869000603	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869000604	Cytochrome c; Region: Cytochrom_C; pfam00034
76869000605	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
76869000606	TIGR02647 family protein; Region: DNA
76869000607	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869000608	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
76869000609	C-terminal domain interface [polypeptide binding]; other site
76869000610	GSH binding site (G-site) [chemical binding]; other site
76869000611	dimer interface [polypeptide binding]; other site
76869000612	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
76869000613	putative N-terminal domain interface [polypeptide binding]; other site
76869000614	putative dimer interface [polypeptide binding]; other site
76869000615	putative substrate binding pocket (H-site) [chemical binding]; other site
76869000616	argininosuccinate lyase; Provisional; Region: PRK00855
76869000617	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
76869000618	active sites [active]
76869000619	tetramer interface [polypeptide binding]; other site
76869000620	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
76869000621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000622	active site
76869000623	phosphorylation site [posttranslational modification]
76869000624	intermolecular recognition site; other site
76869000625	dimerization interface [polypeptide binding]; other site
76869000626	LytTr DNA-binding domain; Region: LytTR; pfam04397
76869000627	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
76869000628	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
76869000629	domain interfaces; other site
76869000630	active site
76869000631	uroporphyrinogen-III synthase; Validated; Region: PRK05752
76869000632	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
76869000633	active site
76869000634	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
76869000635	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
76869000636	HemY protein N-terminus; Region: HemY_N; pfam07219
76869000637	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
76869000638	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
76869000639	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
76869000640	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
76869000641	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869000642	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
76869000643	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
76869000644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869000645	Walker A/P-loop; other site
76869000646	ATP binding site [chemical binding]; other site
76869000647	Q-loop/lid; other site
76869000648	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869000649	ABC transporter signature motif; other site
76869000650	Walker B; other site
76869000651	D-loop; other site
76869000652	ABC transporter; Region: ABC_tran_2; pfam12848
76869000653	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869000654	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
76869000655	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869000656	LysE type translocator; Region: LysE; cl00565
76869000657	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
76869000658	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
76869000659	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
76869000660	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
76869000661	dimer interface [polypeptide binding]; other site
76869000662	active site residues [active]
76869000663	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
76869000664	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
76869000665	putative deacylase active site [active]
76869000666	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
76869000667	FOG: CBS domain [General function prediction only]; Region: COG0517
76869000668	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
76869000669	hypothetical protein; Provisional; Region: PRK06156
76869000670	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
76869000671	active site
76869000672	metal binding site [ion binding]; metal-binding site
76869000673	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
76869000674	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869000675	Walker A/P-loop; other site
76869000676	ATP binding site [chemical binding]; other site
76869000677	Q-loop/lid; other site
76869000678	ABC transporter signature motif; other site
76869000679	Walker B; other site
76869000680	D-loop; other site
76869000681	H-loop/switch region; other site
76869000682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869000683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869000684	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869000685	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869000686	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869000687	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
76869000688	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
76869000689	active site
76869000690	iron coordination sites [ion binding]; other site
76869000691	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869000692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869000693	LysR substrate binding domain; Region: LysR_substrate; pfam03466
76869000694	dimerization interface [polypeptide binding]; other site
76869000695	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
76869000696	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869000697	N-terminal plug; other site
76869000698	ligand-binding site [chemical binding]; other site
76869000699	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
76869000700	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
76869000701	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
76869000702	tetramerization interface [polypeptide binding]; other site
76869000703	NAD(P) binding site [chemical binding]; other site
76869000704	catalytic residues [active]
76869000705	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
76869000706	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869000707	inhibitor-cofactor binding pocket; inhibition site
76869000708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869000709	catalytic residue [active]
76869000710	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869000711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000712	active site
76869000713	phosphorylation site [posttranslational modification]
76869000714	intermolecular recognition site; other site
76869000715	dimerization interface [polypeptide binding]; other site
76869000716	HDOD domain; Region: HDOD; pfam08668
76869000717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869000718	PAS fold; Region: PAS_3; pfam08447
76869000719	putative active site [active]
76869000720	heme pocket [chemical binding]; other site
76869000721	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869000722	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869000723	metal binding site [ion binding]; metal-binding site
76869000724	active site
76869000725	I-site; other site
76869000726	Fatty acid desaturase; Region: FA_desaturase; pfam00487
76869000727	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
76869000728	Di-iron ligands [ion binding]; other site
76869000729	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
76869000730	Transposase; Region: DDE_Tnp_ISL3; pfam01610
76869000731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869000732	PAS domain; Region: PAS_9; pfam13426
76869000733	putative active site [active]
76869000734	heme pocket [chemical binding]; other site
76869000735	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869000736	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869000737	metal binding site [ion binding]; metal-binding site
76869000738	active site
76869000739	I-site; other site
76869000740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869000741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000742	dimer interface [polypeptide binding]; other site
76869000743	conserved gate region; other site
76869000744	ABC-ATPase subunit interface; other site
76869000745	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
76869000746	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
76869000747	Walker A/P-loop; other site
76869000748	ATP binding site [chemical binding]; other site
76869000749	Q-loop/lid; other site
76869000750	ABC transporter signature motif; other site
76869000751	Walker B; other site
76869000752	D-loop; other site
76869000753	H-loop/switch region; other site
76869000754	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
76869000755	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
76869000756	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
76869000757	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869000758	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869000759	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869000760	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
76869000761	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
76869000762	Flavin binding site [chemical binding]; other site
76869000763	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
76869000764	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869000765	active site
76869000766	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
76869000767	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869000768	Walker A/P-loop; other site
76869000769	ATP binding site [chemical binding]; other site
76869000770	Q-loop/lid; other site
76869000771	ABC transporter signature motif; other site
76869000772	Walker B; other site
76869000773	D-loop; other site
76869000774	H-loop/switch region; other site
76869000775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000776	dimer interface [polypeptide binding]; other site
76869000777	conserved gate region; other site
76869000778	putative PBP binding loops; other site
76869000779	ABC-ATPase subunit interface; other site
76869000780	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869000781	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869000782	substrate binding pocket [chemical binding]; other site
76869000783	membrane-bound complex binding site; other site
76869000784	hinge residues; other site
76869000785	serine O-acetyltransferase; Region: cysE; TIGR01172
76869000786	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
76869000787	trimer interface [polypeptide binding]; other site
76869000788	active site
76869000789	substrate binding site [chemical binding]; other site
76869000790	CoA binding site [chemical binding]; other site
76869000791	BCCT family transporter; Region: BCCT; cl00569
76869000792	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
76869000793	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
76869000794	active site
76869000795	iron coordination sites [ion binding]; other site
76869000796	substrate binding pocket [chemical binding]; other site
76869000797	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869000798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000799	dimer interface [polypeptide binding]; other site
76869000800	conserved gate region; other site
76869000801	putative PBP binding loops; other site
76869000802	ABC-ATPase subunit interface; other site
76869000803	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
76869000804	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869000805	Walker A/P-loop; other site
76869000806	ATP binding site [chemical binding]; other site
76869000807	Q-loop/lid; other site
76869000808	ABC transporter signature motif; other site
76869000809	Walker B; other site
76869000810	D-loop; other site
76869000811	H-loop/switch region; other site
76869000812	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
76869000813	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869000814	substrate binding pocket [chemical binding]; other site
76869000815	membrane-bound complex binding site; other site
76869000816	hinge residues; other site
76869000817	outer membrane porin, OprD family; Region: OprD; pfam03573
76869000818	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
76869000819	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
76869000820	dimer interface [polypeptide binding]; other site
76869000821	decamer (pentamer of dimers) interface [polypeptide binding]; other site
76869000822	catalytic triad [active]
76869000823	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
76869000824	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869000825	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869000826	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869000827	substrate binding pocket [chemical binding]; other site
76869000828	membrane-bound complex binding site; other site
76869000829	hinge residues; other site
76869000830	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
76869000831	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
76869000832	active site
76869000833	dimer interface [polypeptide binding]; other site
76869000834	non-prolyl cis peptide bond; other site
76869000835	insertion regions; other site
76869000836	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869000837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000838	dimer interface [polypeptide binding]; other site
76869000839	conserved gate region; other site
76869000840	putative PBP binding loops; other site
76869000841	ABC-ATPase subunit interface; other site
76869000842	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
76869000843	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869000844	Walker A/P-loop; other site
76869000845	ATP binding site [chemical binding]; other site
76869000846	Q-loop/lid; other site
76869000847	ABC transporter signature motif; other site
76869000848	Walker B; other site
76869000849	D-loop; other site
76869000850	H-loop/switch region; other site
76869000851	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
76869000852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869000853	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869000854	glutamate--cysteine ligase; Provisional; Region: PRK02107
76869000855	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
76869000856	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
76869000857	CoenzymeA binding site [chemical binding]; other site
76869000858	subunit interaction site [polypeptide binding]; other site
76869000859	PHB binding site; other site
76869000860	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
76869000861	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
76869000862	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
76869000863	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
76869000864	RNA binding site [nucleotide binding]; other site
76869000865	osmolarity response regulator; Provisional; Region: ompR; PRK09468
76869000866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000867	active site
76869000868	phosphorylation site [posttranslational modification]
76869000869	intermolecular recognition site; other site
76869000870	dimerization interface [polypeptide binding]; other site
76869000871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869000872	DNA binding site [nucleotide binding]
76869000873	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
76869000874	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869000875	dimerization interface [polypeptide binding]; other site
76869000876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000877	ATP binding site [chemical binding]; other site
76869000878	Mg2+ binding site [ion binding]; other site
76869000879	G-X-G motif; other site
76869000880	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
76869000881	RimK-like ATP-grasp domain; Region: RimK; pfam08443
76869000882	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
76869000883	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
76869000884	RNA binding surface [nucleotide binding]; other site
76869000885	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
76869000886	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
76869000887	active site
76869000888	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
76869000889	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
76869000890	dimerization interface [polypeptide binding]; other site
76869000891	domain crossover interface; other site
76869000892	redox-dependent activation switch; other site
76869000893	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
76869000894	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
76869000895	active site
76869000896	substrate-binding site [chemical binding]; other site
76869000897	metal-binding site [ion binding]
76869000898	ATP binding site [chemical binding]; other site
76869000899	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
76869000900	active site
76869000901	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
76869000902	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
76869000903	putative molybdopterin cofactor binding site [chemical binding]; other site
76869000904	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
76869000905	putative molybdopterin cofactor binding site; other site
76869000906	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
76869000907	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
76869000908	BON domain; Region: BON; pfam04972
76869000909	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
76869000910	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
76869000911	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869000912	motif II; other site
76869000913	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
76869000914	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
76869000915	dimer interface [polypeptide binding]; other site
76869000916	ADP-ribose binding site [chemical binding]; other site
76869000917	active site
76869000918	nudix motif; other site
76869000919	metal binding site [ion binding]; metal-binding site
76869000920	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
76869000921	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
76869000922	active site
76869000923	thioesterase domain, putative; Region: yiiD_Cterm; TIGR02447
76869000924	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869000925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000926	active site
76869000927	phosphorylation site [posttranslational modification]
76869000928	intermolecular recognition site; other site
76869000929	dimerization interface [polypeptide binding]; other site
76869000930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869000931	Walker A motif; other site
76869000932	ATP binding site [chemical binding]; other site
76869000933	Walker B motif; other site
76869000934	arginine finger; other site
76869000935	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
76869000936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869000937	dimer interface [polypeptide binding]; other site
76869000938	phosphorylation site [posttranslational modification]
76869000939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000940	ATP binding site [chemical binding]; other site
76869000941	G-X-G motif; other site
76869000942	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
76869000943	agmatine deiminase; Provisional; Region: PRK13551
76869000944	agmatine deiminase; Region: agmatine_aguA; TIGR03380
76869000945	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
76869000946	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869000947	N-terminal plug; other site
76869000948	ligand-binding site [chemical binding]; other site
76869000949	outer membrane porin, OprD family; Region: OprD; pfam03573
76869000950	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
76869000951	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
76869000952	active site
76869000953	FMN binding site [chemical binding]; other site
76869000954	substrate binding site [chemical binding]; other site
76869000955	3Fe-4S cluster binding site [ion binding]; other site
76869000956	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
76869000957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869000958	ATP binding site [chemical binding]; other site
76869000959	Mg2+ binding site [ion binding]; other site
76869000960	G-X-G motif; other site
76869000961	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869000962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869000963	active site
76869000964	phosphorylation site [posttranslational modification]
76869000965	intermolecular recognition site; other site
76869000966	dimerization interface [polypeptide binding]; other site
76869000967	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869000968	DNA binding site [nucleotide binding]
76869000969	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869000970	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869000971	N-terminal plug; other site
76869000972	ligand-binding site [chemical binding]; other site
76869000973	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
76869000974	Methyltransferase domain; Region: Methyltransf_32; pfam13679
76869000975	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869000976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000977	dimer interface [polypeptide binding]; other site
76869000978	conserved gate region; other site
76869000979	putative PBP binding loops; other site
76869000980	ABC-ATPase subunit interface; other site
76869000981	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869000982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869000983	dimer interface [polypeptide binding]; other site
76869000984	conserved gate region; other site
76869000985	putative PBP binding loops; other site
76869000986	ABC-ATPase subunit interface; other site
76869000987	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869000988	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869000989	substrate binding pocket [chemical binding]; other site
76869000990	membrane-bound complex binding site; other site
76869000991	hinge residues; other site
76869000992	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
76869000993	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869000994	Walker A/P-loop; other site
76869000995	ATP binding site [chemical binding]; other site
76869000996	Q-loop/lid; other site
76869000997	ABC transporter signature motif; other site
76869000998	Walker B; other site
76869000999	D-loop; other site
76869001000	H-loop/switch region; other site
76869001001	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
76869001002	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
76869001003	oxidative damage protection protein; Provisional; Region: PRK05408
76869001004	adenine DNA glycosylase; Provisional; Region: PRK10880
76869001005	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
76869001006	minor groove reading motif; other site
76869001007	helix-hairpin-helix signature motif; other site
76869001008	substrate binding pocket [chemical binding]; other site
76869001009	active site
76869001010	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
76869001011	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
76869001012	DNA binding and oxoG recognition site [nucleotide binding]
76869001013	AsmA family; Region: AsmA; pfam05170
76869001014	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
76869001015	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
76869001016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869001017	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
76869001018	putative active site pocket [active]
76869001019	4-fold oligomerization interface [polypeptide binding]; other site
76869001020	metal binding residues [ion binding]; metal-binding site
76869001021	3-fold/trimer interface [polypeptide binding]; other site
76869001022	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
76869001023	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
76869001024	putative active site [active]
76869001025	oxyanion strand; other site
76869001026	catalytic triad [active]
76869001027	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
76869001028	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
76869001029	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
76869001030	catalytic residues [active]
76869001031	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
76869001032	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
76869001033	substrate binding site [chemical binding]; other site
76869001034	glutamase interaction surface [polypeptide binding]; other site
76869001035	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
76869001036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869001037	Walker A/P-loop; other site
76869001038	ATP binding site [chemical binding]; other site
76869001039	Q-loop/lid; other site
76869001040	ABC transporter signature motif; other site
76869001041	Walker B; other site
76869001042	D-loop; other site
76869001043	H-loop/switch region; other site
76869001044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869001045	dimer interface [polypeptide binding]; other site
76869001046	conserved gate region; other site
76869001047	putative PBP binding loops; other site
76869001048	ABC-ATPase subunit interface; other site
76869001049	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
76869001050	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
76869001051	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
76869001052	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
76869001053	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
76869001054	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869001055	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869001056	conserved cys residue [active]
76869001057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869001058	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
76869001059	active site
76869001060	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
76869001061	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
76869001062	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
76869001063	Uncharacterized conserved protein [Function unknown]; Region: COG3246
76869001064	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
76869001065	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
76869001066	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869001067	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869001068	conserved cys residue [active]
76869001069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869001070	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
76869001071	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
76869001072	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
76869001073	active site
76869001074	V4R domain; Region: V4R; cl15268
76869001075	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
76869001076	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
76869001077	putative active site [active]
76869001078	putative FMN binding site [chemical binding]; other site
76869001079	putative substrate binding site [chemical binding]; other site
76869001080	putative catalytic residue [active]
76869001081	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
76869001082	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
76869001083	Cysteine-rich domain; Region: CCG; pfam02754
76869001084	Cysteine-rich domain; Region: CCG; pfam02754
76869001085	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
76869001086	Ligand Binding Site [chemical binding]; other site
76869001087	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
76869001088	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
76869001089	Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086
76869001090	Ligand Binding Site [chemical binding]; other site
76869001091	Electron transfer flavoprotein domain; Region: ETF; pfam01012
76869001092	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869001093	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
76869001094	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
76869001095	[2Fe-2S] cluster binding site [ion binding]; other site
76869001096	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
76869001097	putative alpha subunit interface [polypeptide binding]; other site
76869001098	putative active site [active]
76869001099	putative substrate binding site [chemical binding]; other site
76869001100	Fe binding site [ion binding]; other site
76869001101	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
76869001102	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
76869001103	FAD binding pocket [chemical binding]; other site
76869001104	FAD binding motif [chemical binding]; other site
76869001105	phosphate binding motif [ion binding]; other site
76869001106	beta-alpha-beta structure motif; other site
76869001107	NAD binding pocket [chemical binding]; other site
76869001108	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869001109	catalytic loop [active]
76869001110	iron binding site [ion binding]; other site
76869001111	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
76869001112	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
76869001113	HAMP domain; Region: HAMP; pfam00672
76869001114	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869001115	dimer interface [polypeptide binding]; other site
76869001116	putative CheW interface [polypeptide binding]; other site
76869001117	rod shape-determining protein MreC; Provisional; Region: PRK13922
76869001118	Cell division protein ZapA; Region: ZapA; pfam05164
76869001119	Cache domain; Region: Cache_1; pfam02743
76869001120	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869001121	dimerization interface [polypeptide binding]; other site
76869001122	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869001123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869001124	dimer interface [polypeptide binding]; other site
76869001125	putative CheW interface [polypeptide binding]; other site
76869001126	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
76869001127	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
76869001128	tetramer interface [polypeptide binding]; other site
76869001129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869001130	catalytic residue [active]
76869001131	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
76869001132	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
76869001133	dimer interface [polypeptide binding]; other site
76869001134	active site
76869001135	glycine-pyridoxal phosphate binding site [chemical binding]; other site
76869001136	folate binding site [chemical binding]; other site
76869001137	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
76869001138	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869001139	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
76869001140	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
76869001141	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
76869001142	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
76869001143	Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268
76869001144	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
76869001145	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
76869001146	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
76869001147	putative active site [active]
76869001148	putative substrate binding site [chemical binding]; other site
76869001149	putative cosubstrate binding site; other site
76869001150	catalytic site [active]
76869001151	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
76869001152	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
76869001153	NAD binding site [chemical binding]; other site
76869001154	catalytic Zn binding site [ion binding]; other site
76869001155	structural Zn binding site [ion binding]; other site
76869001156	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869001157	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869001158	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
76869001159	amino acid transporter; Region: 2A0306; TIGR00909
76869001160	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
76869001161	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
76869001162	putative acyl-acceptor binding pocket; other site
76869001163	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
76869001164	DNA-binding response regulator CreB; Provisional; Region: PRK11083
76869001165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869001166	active site
76869001167	phosphorylation site [posttranslational modification]
76869001168	intermolecular recognition site; other site
76869001169	dimerization interface [polypeptide binding]; other site
76869001170	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869001171	DNA binding site [nucleotide binding]
76869001172	sensory histidine kinase CreC; Provisional; Region: PRK11100
76869001173	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869001174	dimer interface [polypeptide binding]; other site
76869001175	phosphorylation site [posttranslational modification]
76869001176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869001177	ATP binding site [chemical binding]; other site
76869001178	G-X-G motif; other site
76869001179	inner membrane protein; Provisional; Region: PRK11715
76869001180	putative glutathione S-transferase; Provisional; Region: PRK10357
76869001181	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
76869001182	putative C-terminal domain interface [polypeptide binding]; other site
76869001183	putative GSH binding site (G-site) [chemical binding]; other site
76869001184	putative dimer interface [polypeptide binding]; other site
76869001185	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
76869001186	dimer interface [polypeptide binding]; other site
76869001187	N-terminal domain interface [polypeptide binding]; other site
76869001188	putative substrate binding pocket (H-site) [chemical binding]; other site
76869001189	methionine sulfoxide reductase A; Provisional; Region: PRK00058
76869001190	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
76869001191	GAF domain; Region: GAF; pfam01590
76869001192	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001193	PAS domain; Region: PAS_9; pfam13426
76869001194	putative active site [active]
76869001195	heme pocket [chemical binding]; other site
76869001196	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869001197	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869001198	metal binding site [ion binding]; metal-binding site
76869001199	active site
76869001200	I-site; other site
76869001201	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869001202	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
76869001203	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869001204	E3 interaction surface; other site
76869001205	lipoyl attachment site [posttranslational modification]; other site
76869001206	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869001207	E3 interaction surface; other site
76869001208	lipoyl attachment site [posttranslational modification]; other site
76869001209	e3 binding domain; Region: E3_binding; pfam02817
76869001210	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
76869001211	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
76869001212	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
76869001213	dimer interface [polypeptide binding]; other site
76869001214	TPP-binding site [chemical binding]; other site
76869001215	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
76869001216	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
76869001217	metal binding triad; other site
76869001218	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
76869001219	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
76869001220	metal binding triad; other site
76869001221	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
76869001222	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
76869001223	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
76869001224	putative active site [active]
76869001225	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
76869001226	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
76869001227	putative active site [active]
76869001228	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869001229	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
76869001230	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
76869001231	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
76869001232	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
76869001233	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
76869001234	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
76869001235	active site
76869001236	ATP binding site [chemical binding]; other site
76869001237	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
76869001238	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
76869001239	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
76869001240	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869001241	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
76869001242	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869001243	N-terminal plug; other site
76869001244	ligand-binding site [chemical binding]; other site
76869001245	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869001246	FecR protein; Region: FecR; pfam04773
76869001247	RNA polymerase sigma factor; Reviewed; Region: PRK12523
76869001248	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869001249	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869001250	DNA binding residues [nucleotide binding]
76869001251	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
76869001252	active site
76869001253	catalytic site [active]
76869001254	substrate binding site [chemical binding]; other site
76869001255	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
76869001256	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
76869001257	ligand binding site [chemical binding]; other site
76869001258	flexible hinge region; other site
76869001259	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
76869001260	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
76869001261	metal binding triad; other site
76869001262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869001263	Response regulator receiver domain; Region: Response_reg; pfam00072
76869001264	active site
76869001265	phosphorylation site [posttranslational modification]
76869001266	intermolecular recognition site; other site
76869001267	dimerization interface [polypeptide binding]; other site
76869001268	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
76869001269	active site
76869001270	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
76869001271	ACT domain; Region: ACT_6; pfam13740
76869001272	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
76869001273	Predicted permeases [General function prediction only]; Region: RarD; COG2962
76869001274	serine/threonine protein kinase; Provisional; Region: PRK11768
76869001275	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
76869001276	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
76869001277	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
76869001278	TOBE domain; Region: TOBE; cl01440
76869001279	TOBE domain; Region: TOBE; cl01440
76869001280	DNA utilization protein GntX; Provisional; Region: PRK11595
76869001281	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869001282	active site
76869001283	biotin synthase; Provisional; Region: PRK15108
76869001284	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869001285	FeS/SAM binding site; other site
76869001286	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
76869001287	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
76869001288	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
76869001289	substrate-cofactor binding pocket; other site
76869001290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869001291	catalytic residue [active]
76869001292	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
76869001293	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
76869001294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869001295	S-adenosylmethionine binding site [chemical binding]; other site
76869001296	AAA domain; Region: AAA_26; pfam13500
76869001297	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
76869001298	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
76869001299	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
76869001300	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869001301	active site
76869001302	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
76869001303	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869001304	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869001305	metal binding site [ion binding]; metal-binding site
76869001306	active site
76869001307	I-site; other site
76869001308	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
76869001309	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
76869001310	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869001311	active site
76869001312	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
76869001313	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869001314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869001315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869001316	dimerization interface [polypeptide binding]; other site
76869001317	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
76869001318	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869001319	inhibitor-cofactor binding pocket; inhibition site
76869001320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869001321	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
76869001322	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
76869001323	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869001324	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
76869001325	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869001326	FeS/SAM binding site; other site
76869001327	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
76869001328	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
76869001329	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
76869001330	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
76869001331	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
76869001332	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
76869001333	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
76869001334	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869001335	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869001336	Predicted amidohydrolase [General function prediction only]; Region: COG0388
76869001337	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
76869001338	putative active site [active]
76869001339	catalytic triad [active]
76869001340	putative dimer interface [polypeptide binding]; other site
76869001341	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
76869001342	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869001343	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869001344	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
76869001345	putative DNA binding site [nucleotide binding]; other site
76869001346	putative Zn2+ binding site [ion binding]; other site
76869001347	AsnC family; Region: AsnC_trans_reg; pfam01037
76869001348	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
76869001349	trimer interface [polypeptide binding]; other site
76869001350	active site
76869001351	substrate binding site [chemical binding]; other site
76869001352	CoA binding site [chemical binding]; other site
76869001353	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869001354	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869001355	substrate binding pocket [chemical binding]; other site
76869001356	membrane-bound complex binding site; other site
76869001357	hinge residues; other site
76869001358	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
76869001359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001360	putative active site [active]
76869001361	heme pocket [chemical binding]; other site
76869001362	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001363	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
76869001364	putative active site [active]
76869001365	heme pocket [chemical binding]; other site
76869001366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001367	putative active site [active]
76869001368	heme pocket [chemical binding]; other site
76869001369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001370	putative active site [active]
76869001371	heme pocket [chemical binding]; other site
76869001372	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869001373	metal binding site [ion binding]; metal-binding site
76869001374	active site
76869001375	I-site; other site
76869001376	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869001377	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
76869001378	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
76869001379	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
76869001380	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
76869001381	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869001382	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
76869001383	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869001384	DNA binding residues [nucleotide binding]
76869001385	DNA primase, catalytic core; Region: dnaG; TIGR01391
76869001386	CHC2 zinc finger; Region: zf-CHC2; pfam01807
76869001387	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
76869001388	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
76869001389	active site
76869001390	metal binding site [ion binding]; metal-binding site
76869001391	interdomain interaction site; other site
76869001392	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
76869001393	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
76869001394	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
76869001395	UGMP family protein; Validated; Region: PRK09604
76869001396	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
76869001397	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
76869001398	Dihydroneopterin aldolase; Region: FolB; smart00905
76869001399	active site
76869001400	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
76869001401	catalytic center binding site [active]
76869001402	ATP binding site [chemical binding]; other site
76869001403	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
76869001404	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
76869001405	active site
76869001406	NTP binding site [chemical binding]; other site
76869001407	metal binding triad [ion binding]; metal-binding site
76869001408	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
76869001409	SpoVR family protein; Provisional; Region: PRK11767
76869001410	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
76869001411	hypothetical protein; Provisional; Region: PRK05325
76869001412	PrkA family serine protein kinase; Provisional; Region: PRK15455
76869001413	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
76869001414	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
76869001415	active site residue [active]
76869001416	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
76869001417	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
76869001418	active site
76869001419	metal binding site [ion binding]; metal-binding site
76869001420	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
76869001421	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
76869001422	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
76869001423	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
76869001424	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
76869001425	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
76869001426	SurA N-terminal domain; Region: SurA_N; pfam09312
76869001427	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
76869001428	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
76869001429	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
76869001430	OstA-like protein; Region: OstA; cl00844
76869001431	Organic solvent tolerance protein; Region: OstA_C; pfam04453
76869001432	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
76869001433	Phosphotransferase enzyme family; Region: APH; pfam01636
76869001434	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
76869001435	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
76869001436	Substrate binding site; other site
76869001437	metal-binding site
76869001438	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
76869001439	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
76869001440	putative metal binding site [ion binding]; other site
76869001441	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
76869001442	HSP70 interaction site [polypeptide binding]; other site
76869001443	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
76869001444	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869001445	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869001446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869001447	substrate binding pocket [chemical binding]; other site
76869001448	membrane-bound complex binding site; other site
76869001449	hinge residues; other site
76869001450	PAS domain; Region: PAS_9; pfam13426
76869001451	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001452	putative active site [active]
76869001453	heme pocket [chemical binding]; other site
76869001454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869001455	PAS fold; Region: PAS_3; pfam08447
76869001456	putative active site [active]
76869001457	heme pocket [chemical binding]; other site
76869001458	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
76869001459	Histidine kinase; Region: HisKA_3; pfam07730
76869001460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869001461	ATP binding site [chemical binding]; other site
76869001462	Mg2+ binding site [ion binding]; other site
76869001463	G-X-G motif; other site
76869001464	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869001465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869001466	active site
76869001467	phosphorylation site [posttranslational modification]
76869001468	intermolecular recognition site; other site
76869001469	dimerization interface [polypeptide binding]; other site
76869001470	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869001471	DNA binding residues [nucleotide binding]
76869001472	dimerization interface [polypeptide binding]; other site
76869001473	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
76869001474	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
76869001475	Walker A/P-loop; other site
76869001476	ATP binding site [chemical binding]; other site
76869001477	Q-loop/lid; other site
76869001478	ABC transporter signature motif; other site
76869001479	Walker B; other site
76869001480	D-loop; other site
76869001481	H-loop/switch region; other site
76869001482	TOBE domain; Region: TOBE_2; pfam08402
76869001483	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
76869001484	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869001485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869001486	dimer interface [polypeptide binding]; other site
76869001487	conserved gate region; other site
76869001488	putative PBP binding loops; other site
76869001489	ABC-ATPase subunit interface; other site
76869001490	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869001491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869001492	dimer interface [polypeptide binding]; other site
76869001493	conserved gate region; other site
76869001494	putative PBP binding loops; other site
76869001495	ABC-ATPase subunit interface; other site
76869001496	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
76869001497	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
76869001498	substrate binding site [chemical binding]; other site
76869001499	hexamer interface [polypeptide binding]; other site
76869001500	metal binding site [ion binding]; metal-binding site
76869001501	phosphoglycolate phosphatase; Provisional; Region: PRK13223
76869001502	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
76869001503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869001504	motif II; other site
76869001505	anthranilate synthase component I; Provisional; Region: PRK13565
76869001506	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
76869001507	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
76869001508	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
76869001509	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
76869001510	active site
76869001511	catalytic triad [active]
76869001512	oxyanion hole [active]
76869001513	Autotransporter beta-domain; Region: Autotransporter; pfam03797
76869001514	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
76869001515	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
76869001516	glutamine binding [chemical binding]; other site
76869001517	catalytic triad [active]
76869001518	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
76869001519	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
76869001520	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
76869001521	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
76869001522	active site
76869001523	ribulose/triose binding site [chemical binding]; other site
76869001524	phosphate binding site [ion binding]; other site
76869001525	substrate (anthranilate) binding pocket [chemical binding]; other site
76869001526	product (indole) binding pocket [chemical binding]; other site
76869001527	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
76869001528	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
76869001529	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
76869001530	ligand binding site [chemical binding]; other site
76869001531	flexible hinge region; other site
76869001532	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
76869001533	putative switch regulator; other site
76869001534	non-specific DNA interactions [nucleotide binding]; other site
76869001535	DNA binding site [nucleotide binding]
76869001536	sequence specific DNA binding site [nucleotide binding]; other site
76869001537	putative cAMP binding site [chemical binding]; other site
76869001538	OsmC-like protein; Region: OsmC; cl00767
76869001539	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
76869001540	diiron binding motif [ion binding]; other site
76869001541	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
76869001542	nucleotide binding site/active site [active]
76869001543	HIT family signature motif; other site
76869001544	catalytic residue [active]
76869001545	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
76869001546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869001547	NAD(P) binding site [chemical binding]; other site
76869001548	active site
76869001549	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
76869001550	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
76869001551	FMN binding site [chemical binding]; other site
76869001552	substrate binding site [chemical binding]; other site
76869001553	putative catalytic residue [active]
76869001554	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
76869001555	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
76869001556	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
76869001557	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
76869001558	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
76869001559	putative peptidase; Provisional; Region: PRK11649
76869001560	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
76869001561	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869001562	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
76869001563	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
76869001564	active site
76869001565	HIGH motif; other site
76869001566	dimer interface [polypeptide binding]; other site
76869001567	KMSKS motif; other site
76869001568	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
76869001569	Biotin operon repressor [Transcription]; Region: BirA; COG1654
76869001570	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
76869001571	pantothenate kinase; Reviewed; Region: PRK13322
76869001572	elongation factor Tu; Reviewed; Region: PRK00049
76869001573	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
76869001574	G1 box; other site
76869001575	GEF interaction site [polypeptide binding]; other site
76869001576	GTP/Mg2+ binding site [chemical binding]; other site
76869001577	Switch I region; other site
76869001578	G2 box; other site
76869001579	G3 box; other site
76869001580	Switch II region; other site
76869001581	G4 box; other site
76869001582	G5 box; other site
76869001583	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
76869001584	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
76869001585	Antibiotic Binding Site [chemical binding]; other site
76869001586	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
76869001587	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
76869001588	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
76869001589	putative homodimer interface [polypeptide binding]; other site
76869001590	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
76869001591	heterodimer interface [polypeptide binding]; other site
76869001592	homodimer interface [polypeptide binding]; other site
76869001593	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
76869001594	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
76869001595	23S rRNA interface [nucleotide binding]; other site
76869001596	L7/L12 interface [polypeptide binding]; other site
76869001597	putative thiostrepton binding site; other site
76869001598	L25 interface [polypeptide binding]; other site
76869001599	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
76869001600	mRNA/rRNA interface [nucleotide binding]; other site
76869001601	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
76869001602	23S rRNA interface [nucleotide binding]; other site
76869001603	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
76869001604	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
76869001605	core dimer interface [polypeptide binding]; other site
76869001606	peripheral dimer interface [polypeptide binding]; other site
76869001607	L10 interface [polypeptide binding]; other site
76869001608	L11 interface [polypeptide binding]; other site
76869001609	putative EF-Tu interaction site [polypeptide binding]; other site
76869001610	putative EF-G interaction site [polypeptide binding]; other site
76869001611	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
76869001612	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
76869001613	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
76869001614	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
76869001615	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
76869001616	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
76869001617	RPB3 interaction site [polypeptide binding]; other site
76869001618	RPB1 interaction site [polypeptide binding]; other site
76869001619	RPB11 interaction site [polypeptide binding]; other site
76869001620	RPB10 interaction site [polypeptide binding]; other site
76869001621	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
76869001622	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
76869001623	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
76869001624	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
76869001625	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
76869001626	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
76869001627	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
76869001628	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
76869001629	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
76869001630	DNA binding site [nucleotide binding]
76869001631	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
76869001632	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
76869001633	S17 interaction site [polypeptide binding]; other site
76869001634	S8 interaction site; other site
76869001635	16S rRNA interaction site [nucleotide binding]; other site
76869001636	streptomycin interaction site [chemical binding]; other site
76869001637	23S rRNA interaction site [nucleotide binding]; other site
76869001638	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
76869001639	30S ribosomal protein S7; Validated; Region: PRK05302
76869001640	elongation factor G; Reviewed; Region: PRK00007
76869001641	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
76869001642	G1 box; other site
76869001643	putative GEF interaction site [polypeptide binding]; other site
76869001644	GTP/Mg2+ binding site [chemical binding]; other site
76869001645	Switch I region; other site
76869001646	G2 box; other site
76869001647	G3 box; other site
76869001648	Switch II region; other site
76869001649	G4 box; other site
76869001650	G5 box; other site
76869001651	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
76869001652	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
76869001653	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
76869001654	elongation factor Tu; Reviewed; Region: PRK00049
76869001655	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
76869001656	G1 box; other site
76869001657	GEF interaction site [polypeptide binding]; other site
76869001658	GTP/Mg2+ binding site [chemical binding]; other site
76869001659	Switch I region; other site
76869001660	G2 box; other site
76869001661	G3 box; other site
76869001662	Switch II region; other site
76869001663	G4 box; other site
76869001664	G5 box; other site
76869001665	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
76869001666	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
76869001667	Antibiotic Binding Site [chemical binding]; other site
76869001668	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
76869001669	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
76869001670	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
76869001671	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
76869001672	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
76869001673	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
76869001674	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
76869001675	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
76869001676	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
76869001677	protein-rRNA interface [nucleotide binding]; other site
76869001678	putative translocon binding site; other site
76869001679	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
76869001680	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
76869001681	G-X-X-G motif; other site
76869001682	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
76869001683	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
76869001684	23S rRNA interface [nucleotide binding]; other site
76869001685	5S rRNA interface [nucleotide binding]; other site
76869001686	putative antibiotic binding site [chemical binding]; other site
76869001687	L25 interface [polypeptide binding]; other site
76869001688	L27 interface [polypeptide binding]; other site
76869001689	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
76869001690	23S rRNA interface [nucleotide binding]; other site
76869001691	putative translocon interaction site; other site
76869001692	signal recognition particle (SRP54) interaction site; other site
76869001693	L23 interface [polypeptide binding]; other site
76869001694	trigger factor interaction site; other site
76869001695	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
76869001696	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
76869001697	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
76869001698	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
76869001699	RNA binding site [nucleotide binding]; other site
76869001700	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
76869001701	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
76869001702	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
76869001703	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
76869001704	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
76869001705	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
76869001706	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
76869001707	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
76869001708	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
76869001709	5S rRNA interface [nucleotide binding]; other site
76869001710	23S rRNA interface [nucleotide binding]; other site
76869001711	L5 interface [polypeptide binding]; other site
76869001712	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
76869001713	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
76869001714	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
76869001715	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
76869001716	23S rRNA binding site [nucleotide binding]; other site
76869001717	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
76869001718	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
76869001719	SecY translocase; Region: SecY; pfam00344
76869001720	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
76869001721	30S ribosomal protein S13; Region: bact_S13; TIGR03631
76869001722	30S ribosomal protein S11; Validated; Region: PRK05309
76869001723	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
76869001724	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
76869001725	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
76869001726	RNA binding surface [nucleotide binding]; other site
76869001727	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
76869001728	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
76869001729	alphaNTD homodimer interface [polypeptide binding]; other site
76869001730	alphaNTD - beta interaction site [polypeptide binding]; other site
76869001731	alphaNTD - beta' interaction site [polypeptide binding]; other site
76869001732	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
76869001733	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
76869001734	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
76869001735	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
76869001736	tetramer interface [polypeptide binding]; other site
76869001737	heme binding pocket [chemical binding]; other site
76869001738	NADPH binding site [chemical binding]; other site
76869001739	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
76869001740	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
76869001741	heme binding site [chemical binding]; other site
76869001742	ferroxidase pore; other site
76869001743	ferroxidase diiron center [ion binding]; other site
76869001744	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
76869001745	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
76869001746	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
76869001747	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
76869001748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869001749	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869001750	putative substrate translocation pore; other site
76869001751	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
76869001752	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
76869001753	dimer interface [polypeptide binding]; other site
76869001754	ssDNA binding site [nucleotide binding]; other site
76869001755	tetramer (dimer of dimers) interface [polypeptide binding]; other site
76869001756	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869001757	active site
76869001758	Int/Topo IB signature motif; other site
76869001759	catalytic residues [active]
76869001760	DNA binding site [nucleotide binding]
76869001761	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869001762	active site
76869001763	catalytic residues [active]
76869001764	DNA binding site [nucleotide binding]
76869001765	Int/Topo IB signature motif; other site
76869001766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688
76869001767	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869001768	DNA binding site [nucleotide binding]
76869001769	active site
76869001770	Int/Topo IB signature motif; other site
76869001771	catalytic residues [active]
76869001772	Protein of unknown function (DUF972); Region: DUF972; pfam06156
76869001773	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869001774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869001775	non-specific DNA binding site [nucleotide binding]; other site
76869001776	salt bridge; other site
76869001777	sequence-specific DNA binding site [nucleotide binding]; other site
76869001778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
76869001779	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
76869001780	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
76869001781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
76869001782	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
76869001783	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
76869001784	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
76869001785	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
76869001786	ATP binding site [chemical binding]; other site
76869001787	Mg2+ binding site [ion binding]; other site
76869001788	G-X-G motif; other site
76869001789	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
76869001790	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
76869001791	cofactor binding site; other site
76869001792	DNA binding site [nucleotide binding]
76869001793	substrate interaction site [chemical binding]; other site
76869001794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
76869001795	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
76869001796	additional DNA contacts [nucleotide binding]; other site
76869001797	mismatch recognition site; other site
76869001798	active site
76869001799	zinc binding site [ion binding]; other site
76869001800	DNA intercalation site [nucleotide binding]; other site
76869001801	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
76869001802	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
76869001803	molybdopterin cofactor binding site; other site
76869001804	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
76869001805	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
76869001806	molybdopterin cofactor binding site; other site
76869001807	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
76869001808	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
76869001809	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
76869001810	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
76869001811	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
76869001812	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
76869001813	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
76869001814	selenocysteine synthase; Provisional; Region: PRK04311
76869001815	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
76869001816	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
76869001817	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869001818	catalytic residue [active]
76869001819	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
76869001820	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
76869001821	G1 box; other site
76869001822	putative GEF interaction site [polypeptide binding]; other site
76869001823	GTP/Mg2+ binding site [chemical binding]; other site
76869001824	Switch I region; other site
76869001825	G2 box; other site
76869001826	G3 box; other site
76869001827	Switch II region; other site
76869001828	G4 box; other site
76869001829	G5 box; other site
76869001830	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
76869001831	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
76869001832	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
76869001833	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
76869001834	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
76869001835	active site
76869001836	homodimer interface [polypeptide binding]; other site
76869001837	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
76869001838	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
76869001839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869001840	sequence-specific DNA binding site [nucleotide binding]; other site
76869001841	salt bridge; other site
76869001842	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869001843	hypothetical protein; Provisional; Region: PRK10621
76869001844	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869001845	trimethyllysine dioxygenase; Region: carnitine_TMLD; TIGR02410
76869001846	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
76869001847	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
76869001848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869001849	NAD(P) binding site [chemical binding]; other site
76869001850	active site
76869001851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869001852	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
76869001853	NAD(P) binding site [chemical binding]; other site
76869001854	active site
76869001855	Predicted transcriptional regulators [Transcription]; Region: COG1733
76869001856	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
76869001857	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869001858	OmpW family; Region: OmpW; cl17427
76869001859	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
76869001860	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
76869001861	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
76869001862	FtsX-like permease family; Region: FtsX; pfam02687
76869001863	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
76869001864	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
76869001865	Walker A/P-loop; other site
76869001866	ATP binding site [chemical binding]; other site
76869001867	Q-loop/lid; other site
76869001868	ABC transporter signature motif; other site
76869001869	Walker B; other site
76869001870	D-loop; other site
76869001871	H-loop/switch region; other site
76869001872	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
76869001873	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
76869001874	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
76869001875	Predicted methyltransferase [General function prediction only]; Region: COG3897
76869001876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
76869001877	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
76869001878	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
76869001879	ATP cone domain; Region: ATP-cone; pfam03477
76869001880	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
76869001881	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
76869001882	catalytic motif [active]
76869001883	Zn binding site [ion binding]; other site
76869001884	RibD C-terminal domain; Region: RibD_C; cl17279
76869001885	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
76869001886	Lumazine binding domain; Region: Lum_binding; pfam00677
76869001887	Lumazine binding domain; Region: Lum_binding; pfam00677
76869001888	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
76869001889	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
76869001890	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
76869001891	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
76869001892	homopentamer interface [polypeptide binding]; other site
76869001893	active site
76869001894	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
76869001895	putative RNA binding site [nucleotide binding]; other site
76869001896	thiamine monophosphate kinase; Provisional; Region: PRK05731
76869001897	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
76869001898	ATP binding site [chemical binding]; other site
76869001899	dimerization interface [polypeptide binding]; other site
76869001900	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
76869001901	tetramer interfaces [polypeptide binding]; other site
76869001902	binuclear metal-binding site [ion binding]; other site
76869001903	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869001904	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869001905	membrane-bound complex binding site; other site
76869001906	hinge residues; other site
76869001907	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
76869001908	dimerization interface [polypeptide binding]; other site
76869001909	active site
76869001910	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
76869001911	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
76869001912	cobalamin binding residues [chemical binding]; other site
76869001913	putative BtuC binding residues; other site
76869001914	dimer interface [polypeptide binding]; other site
76869001915	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869001916	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
76869001917	N-terminal plug; other site
76869001918	ligand-binding site [chemical binding]; other site
76869001919	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
76869001920	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
76869001921	TPP-binding site; other site
76869001922	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
76869001923	PYR/PP interface [polypeptide binding]; other site
76869001924	dimer interface [polypeptide binding]; other site
76869001925	TPP binding site [chemical binding]; other site
76869001926	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
76869001927	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
76869001928	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
76869001929	substrate binding pocket [chemical binding]; other site
76869001930	chain length determination region; other site
76869001931	substrate-Mg2+ binding site; other site
76869001932	catalytic residues [active]
76869001933	aspartate-rich region 1; other site
76869001934	active site lid residues [active]
76869001935	aspartate-rich region 2; other site
76869001936	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
76869001937	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
76869001938	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
76869001939	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
76869001940	hypothetical protein; Reviewed; Region: PRK09588
76869001941	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
76869001942	Putative esterase; Region: Esterase; pfam00756
76869001943	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869001944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869001945	phosphorylation site [posttranslational modification]
76869001946	dimer interface [polypeptide binding]; other site
76869001947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869001948	ATP binding site [chemical binding]; other site
76869001949	Mg2+ binding site [ion binding]; other site
76869001950	G-X-G motif; other site
76869001951	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869001952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869001953	active site
76869001954	phosphorylation site [posttranslational modification]
76869001955	intermolecular recognition site; other site
76869001956	dimerization interface [polypeptide binding]; other site
76869001957	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869001958	DNA binding site [nucleotide binding]
76869001959	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869001960	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869001961	N-terminal plug; other site
76869001962	ligand-binding site [chemical binding]; other site
76869001963	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869001964	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
76869001965	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869001966	non-specific DNA binding site [nucleotide binding]; other site
76869001967	salt bridge; other site
76869001968	sequence-specific DNA binding site [nucleotide binding]; other site
76869001969	Predicted transcriptional regulator [Transcription]; Region: COG2932
76869001970	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869001971	Catalytic site [active]
76869001972	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
76869001973	dimer interface [polypeptide binding]; other site
76869001974	substrate binding site [chemical binding]; other site
76869001975	metal binding sites [ion binding]; metal-binding site
76869001976	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
76869001977	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
76869001978	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
76869001979	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
76869001980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869001981	Coenzyme A binding pocket [chemical binding]; other site
76869001982	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
76869001983	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
76869001984	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
76869001985	ethanolamine permease; Region: 2A0305; TIGR00908
76869001986	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869001987	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869001988	NAD(P) binding site [chemical binding]; other site
76869001989	catalytic residues [active]
76869001990	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
76869001991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869001992	Walker A motif; other site
76869001993	ATP binding site [chemical binding]; other site
76869001994	Walker B motif; other site
76869001995	arginine finger; other site
76869001996	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869001997	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
76869001998	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
76869001999	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
76869002000	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
76869002001	aromatic acid decarboxylase; Validated; Region: PRK05920
76869002002	Flavoprotein; Region: Flavoprotein; pfam02441
76869002003	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
76869002004	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
76869002005	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
76869002006	NAD binding site [chemical binding]; other site
76869002007	active site
76869002008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
76869002009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
76869002010	Peptidase C13 family; Region: Peptidase_C13; pfam01650
76869002011	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
76869002012	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
76869002013	putative NAD(P) binding site [chemical binding]; other site
76869002014	catalytic Zn binding site [ion binding]; other site
76869002015	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
76869002016	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869002017	E3 interaction surface; other site
76869002018	lipoyl attachment site [posttranslational modification]; other site
76869002019	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
76869002020	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
76869002021	alpha subunit interface [polypeptide binding]; other site
76869002022	TPP binding site [chemical binding]; other site
76869002023	heterodimer interface [polypeptide binding]; other site
76869002024	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
76869002025	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
76869002026	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
76869002027	tetramer interface [polypeptide binding]; other site
76869002028	TPP-binding site [chemical binding]; other site
76869002029	heterodimer interface [polypeptide binding]; other site
76869002030	phosphorylation loop region [posttranslational modification]
76869002031	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
76869002032	ATP-NAD kinase; Region: NAD_kinase; pfam01513
76869002033	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
76869002034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869002035	Walker A motif; other site
76869002036	ATP binding site [chemical binding]; other site
76869002037	Walker B motif; other site
76869002038	arginine finger; other site
76869002039	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869002040	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
76869002041	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
76869002042	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
76869002043	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
76869002044	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
76869002045	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
76869002046	carboxyltransferase (CT) interaction site; other site
76869002047	biotinylation site [posttranslational modification]; other site
76869002048	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
76869002049	Dehydroquinase class II; Region: DHquinase_II; pfam01220
76869002050	active site
76869002051	trimer interface [polypeptide binding]; other site
76869002052	dimer interface [polypeptide binding]; other site
76869002053	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
76869002054	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
76869002055	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
76869002056	DsbD alpha interface [polypeptide binding]; other site
76869002057	catalytic residues [active]
76869002058	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869002059	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869002060	dimer interface [polypeptide binding]; other site
76869002061	putative CheW interface [polypeptide binding]; other site
76869002062	Response regulator receiver domain; Region: Response_reg; pfam00072
76869002063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
76869002064	active site
76869002065	phosphorylation site [posttranslational modification]
76869002066	intermolecular recognition site; other site
76869002067	dimerization interface [polypeptide binding]; other site
76869002068	Response regulator receiver domain; Region: Response_reg; pfam00072
76869002069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869002070	active site
76869002071	phosphorylation site [posttranslational modification]
76869002072	intermolecular recognition site; other site
76869002073	dimerization interface [polypeptide binding]; other site
76869002074	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869002075	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869002076	metal binding site [ion binding]; metal-binding site
76869002077	active site
76869002078	I-site; other site
76869002079	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
76869002080	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
76869002081	nudix motif; other site
76869002082	translation initiation factor Sui1; Validated; Region: PRK06824
76869002083	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
76869002084	putative rRNA binding site [nucleotide binding]; other site
76869002085	arginine decarboxylase; Provisional; Region: PRK05354
76869002086	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
76869002087	dimer interface [polypeptide binding]; other site
76869002088	active site
76869002089	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869002090	catalytic residues [active]
76869002091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
76869002092	Transposase IS200 like; Region: Y1_Tnp; pfam01797
76869002093	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
76869002094	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
76869002095	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
76869002096	MG2 domain; Region: A2M_N; pfam01835
76869002097	Alpha-2-macroglobulin family; Region: A2M; pfam00207
76869002098	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
76869002099	surface patch; other site
76869002100	thioester region; other site
76869002101	specificity defining residues; other site
76869002102	penicillin-binding protein 1C; Provisional; Region: PRK11240
76869002103	Transglycosylase; Region: Transgly; pfam00912
76869002104	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
76869002105	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
76869002106	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
76869002107	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
76869002108	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869002109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869002110	active site
76869002111	phosphorylation site [posttranslational modification]
76869002112	intermolecular recognition site; other site
76869002113	dimerization interface [polypeptide binding]; other site
76869002114	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869002115	DNA binding residues [nucleotide binding]
76869002116	dimerization interface [polypeptide binding]; other site
76869002117	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
76869002118	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
76869002119	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
76869002120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869002121	S-adenosylmethionine binding site [chemical binding]; other site
76869002122	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
76869002123	homodimer interface [polypeptide binding]; other site
76869002124	chemical substrate binding site [chemical binding]; other site
76869002125	oligomer interface [polypeptide binding]; other site
76869002126	metal binding site [ion binding]; metal-binding site
76869002127	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
76869002128	active site 2 [active]
76869002129	active site 1 [active]
76869002130	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
76869002131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869002132	NAD(P) binding site [chemical binding]; other site
76869002133	active site
76869002134	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
76869002135	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869002136	dimer interface [polypeptide binding]; other site
76869002137	active site
76869002138	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869002139	Cache domain; Region: Cache_1; pfam02743
76869002140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869002141	dimerization interface [polypeptide binding]; other site
76869002142	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869002143	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869002144	dimer interface [polypeptide binding]; other site
76869002145	putative CheW interface [polypeptide binding]; other site
76869002146	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
76869002147	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
76869002148	DNA binding residues [nucleotide binding]
76869002149	dimer interface [polypeptide binding]; other site
76869002150	copper binding site [ion binding]; other site
76869002151	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
76869002152	metal-binding site [ion binding]
76869002153	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
76869002154	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
76869002155	metal-binding site [ion binding]
76869002156	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869002157	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
76869002158	metal-binding site [ion binding]
76869002159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869002160	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
76869002161	putative substrate translocation pore; other site
76869002162	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
76869002163	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
76869002164	active site
76869002165	purine riboside binding site [chemical binding]; other site
76869002166	short chain dehydrogenase; Provisional; Region: PRK08177
76869002167	C factor cell-cell signaling protein; Provisional; Region: PRK09009
76869002168	NAD(P) binding site [chemical binding]; other site
76869002169	active site
76869002170	Uncharacterized conserved protein [Function unknown]; Region: COG1739
76869002171	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
76869002172	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
76869002173	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
76869002174	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869002175	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
76869002176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869002177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869002178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869002179	dimerization interface [polypeptide binding]; other site
76869002180	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
76869002181	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869002182	inhibitor-cofactor binding pocket; inhibition site
76869002183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869002184	catalytic residue [active]
76869002185	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
76869002186	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
76869002187	tetrameric interface [polypeptide binding]; other site
76869002188	NAD binding site [chemical binding]; other site
76869002189	catalytic residues [active]
76869002190	Paraquat-inducible protein A; Region: PqiA; pfam04403
76869002191	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
76869002192	Paraquat-inducible protein A; Region: PqiA; pfam04403
76869002193	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
76869002194	mce related protein; Region: MCE; pfam02470
76869002195	mce related protein; Region: MCE; pfam02470
76869002196	mce related protein; Region: MCE; pfam02470
76869002197	mce related protein; Region: MCE; pfam02470
76869002198	mce related protein; Region: MCE; pfam02470
76869002199	mce related protein; Region: MCE; pfam02470
76869002200	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
76869002201	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
76869002202	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
76869002203	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
76869002204	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
76869002205	active site
76869002206	Riboflavin kinase; Region: Flavokinase; pfam01687
76869002207	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
76869002208	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
76869002209	active site
76869002210	HIGH motif; other site
76869002211	nucleotide binding site [chemical binding]; other site
76869002212	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
76869002213	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
76869002214	active site
76869002215	KMSKS motif; other site
76869002216	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
76869002217	tRNA binding surface [nucleotide binding]; other site
76869002218	anticodon binding site; other site
76869002219	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
76869002220	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
76869002221	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
76869002222	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869002223	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
76869002224	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
76869002225	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
76869002226	Type II transport protein GspH; Region: GspH; pfam12019
76869002227	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
76869002228	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
76869002229	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
76869002230	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
76869002231	putative amidase; Provisional; Region: PRK06169
76869002232	Amidase; Region: Amidase; pfam01425
76869002233	allantoate amidohydrolase; Reviewed; Region: PRK12893
76869002234	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
76869002235	active site
76869002236	metal binding site [ion binding]; metal-binding site
76869002237	dimer interface [polypeptide binding]; other site
76869002238	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
76869002239	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
76869002240	Walker A/P-loop; other site
76869002241	ATP binding site [chemical binding]; other site
76869002242	Q-loop/lid; other site
76869002243	ABC transporter signature motif; other site
76869002244	Walker B; other site
76869002245	D-loop; other site
76869002246	H-loop/switch region; other site
76869002247	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
76869002248	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
76869002249	Walker A/P-loop; other site
76869002250	ATP binding site [chemical binding]; other site
76869002251	Q-loop/lid; other site
76869002252	ABC transporter signature motif; other site
76869002253	Walker B; other site
76869002254	D-loop; other site
76869002255	H-loop/switch region; other site
76869002256	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
76869002257	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
76869002258	TM-ABC transporter signature motif; other site
76869002259	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
76869002260	TM-ABC transporter signature motif; other site
76869002261	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
76869002262	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
76869002263	putative ligand binding site [chemical binding]; other site
76869002264	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869002265	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869002266	DNA-binding site [nucleotide binding]; DNA binding site
76869002267	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869002268	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
76869002269	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
76869002270	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
76869002271	RNA binding surface [nucleotide binding]; other site
76869002272	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
76869002273	active site
76869002274	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
76869002275	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
76869002276	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
76869002277	Clp amino terminal domain; Region: Clp_N; pfam02861
76869002278	Clp amino terminal domain; Region: Clp_N; pfam02861
76869002279	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869002280	Walker A motif; other site
76869002281	ATP binding site [chemical binding]; other site
76869002282	Walker B motif; other site
76869002283	arginine finger; other site
76869002284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869002285	Walker A motif; other site
76869002286	ATP binding site [chemical binding]; other site
76869002287	Walker B motif; other site
76869002288	arginine finger; other site
76869002289	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
76869002290	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
76869002291	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869002292	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
76869002293	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
76869002294	Predicted membrane protein [Function unknown]; Region: COG3235
76869002295	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
76869002296	DNA gyrase inhibitor; Reviewed; Region: PRK00418
76869002297	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
76869002298	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
76869002299	CoA-binding site [chemical binding]; other site
76869002300	ATP-binding [chemical binding]; other site
76869002301	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
76869002302	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
76869002303	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
76869002304	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
76869002305	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
76869002306	Pilin (bacterial filament); Region: Pilin; pfam00114
76869002307	integrase; Provisional; Region: PRK09692
76869002308	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
76869002309	active site
76869002310	Int/Topo IB signature motif; other site
76869002311	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
76869002312	TrfA protein; Region: TrfA; pfam07042
76869002313	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869002314	active site
76869002315	catalytic residues [active]
76869002316	DNA binding site [nucleotide binding]
76869002317	Int/Topo IB signature motif; other site
76869002318	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869002319	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002320	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869002321	DNA binding residues [nucleotide binding]
76869002322	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869002323	FecR protein; Region: FecR; pfam04773
76869002324	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002325	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
76869002326	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002327	N-terminal plug; other site
76869002328	ligand-binding site [chemical binding]; other site
76869002329	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002330	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869002331	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002332	N-terminal plug; other site
76869002333	ligand-binding site [chemical binding]; other site
76869002334	fec operon regulator FecR; Reviewed; Region: PRK09774
76869002335	FecR protein; Region: FecR; pfam04773
76869002336	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869002337	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002338	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869002339	DNA binding residues [nucleotide binding]
76869002340	fructuronate transporter; Provisional; Region: PRK10034; cl15264
76869002341	GntP family permease; Region: GntP_permease; pfam02447
76869002342	malate dehydrogenase; Reviewed; Region: PRK06223
76869002343	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
76869002344	NAD(P) binding site [chemical binding]; other site
76869002345	dimer interface [polypeptide binding]; other site
76869002346	tetramer (dimer of dimers) interface [polypeptide binding]; other site
76869002347	substrate binding site [chemical binding]; other site
76869002348	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869002349	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
76869002350	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002351	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869002352	DNA binding residues [nucleotide binding]
76869002353	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869002354	FecR protein; Region: FecR; pfam04773
76869002355	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002356	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
76869002357	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002358	N-terminal plug; other site
76869002359	ligand-binding site [chemical binding]; other site
76869002360	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
76869002361	Sodium Bile acid symporter family; Region: SBF; cl17470
76869002362	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
76869002363	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
76869002364	dimer interface [polypeptide binding]; other site
76869002365	active site
76869002366	glycine-pyridoxal phosphate binding site [chemical binding]; other site
76869002367	folate binding site [chemical binding]; other site
76869002368	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
76869002369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869002370	putative active site [active]
76869002371	heme pocket [chemical binding]; other site
76869002372	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
76869002373	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869002374	putative active site [active]
76869002375	heme pocket [chemical binding]; other site
76869002376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869002377	metal binding site [ion binding]; metal-binding site
76869002378	active site
76869002379	I-site; other site
76869002380	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869002381	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
76869002382	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869002383	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869002384	ABC transporter; Region: ABC_tran_2; pfam12848
76869002385	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869002386	glutamate dehydrogenase; Provisional; Region: PRK09414
76869002387	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
76869002388	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
76869002389	NAD(P) binding site [chemical binding]; other site
76869002390	transcription elongation factor regulatory protein; Validated; Region: PRK06342
76869002391	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
76869002392	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
76869002393	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
76869002394	AAA domain; Region: AAA_32; pfam13654
76869002395	ATP-dependent protease Lon; Provisional; Region: PRK13765
76869002396	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
76869002397	hypothetical protein; Provisional; Region: PRK05208
76869002398	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
76869002399	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
76869002400	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869002401	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355
76869002402	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
76869002403	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
76869002404	PhnA protein; Region: PhnA; pfam03831
76869002405	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
76869002406	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
76869002407	substrate binding pocket [chemical binding]; other site
76869002408	chain length determination region; other site
76869002409	substrate-Mg2+ binding site; other site
76869002410	catalytic residues [active]
76869002411	aspartate-rich region 1; other site
76869002412	active site lid residues [active]
76869002413	aspartate-rich region 2; other site
76869002414	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
76869002415	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
76869002416	GTPase CgtA; Reviewed; Region: obgE; PRK12298
76869002417	GTP1/OBG; Region: GTP1_OBG; pfam01018
76869002418	Obg GTPase; Region: Obg; cd01898
76869002419	G1 box; other site
76869002420	GTP/Mg2+ binding site [chemical binding]; other site
76869002421	Switch I region; other site
76869002422	G2 box; other site
76869002423	G3 box; other site
76869002424	Switch II region; other site
76869002425	G4 box; other site
76869002426	G5 box; other site
76869002427	gamma-glutamyl kinase; Provisional; Region: PRK05429
76869002428	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
76869002429	nucleotide binding site [chemical binding]; other site
76869002430	homotetrameric interface [polypeptide binding]; other site
76869002431	putative phosphate binding site [ion binding]; other site
76869002432	putative allosteric binding site; other site
76869002433	PUA domain; Region: PUA; pfam01472
76869002434	hypothetical protein; Provisional; Region: PRK10756
76869002435	CreA protein; Region: CreA; pfam05981
76869002436	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
76869002437	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
76869002438	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
76869002439	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
76869002440	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869002441	Coenzyme A binding pocket [chemical binding]; other site
76869002442	Peptidase M15; Region: Peptidase_M15_3; cl01194
76869002443	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869002444	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869002445	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869002446	dimerization interface [polypeptide binding]; other site
76869002447	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869002448	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869002449	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869002450	FecR protein; Region: FecR; pfam04773
76869002451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869002452	putative substrate translocation pore; other site
76869002453	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869002454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869002455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869002456	putative substrate translocation pore; other site
76869002457	fec operon regulator FecR; Reviewed; Region: PRK09774
76869002458	FecR protein; Region: FecR; pfam04773
76869002459	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869002460	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002461	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869002462	DNA binding residues [nucleotide binding]
76869002463	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
76869002464	endonuclease III; Region: ENDO3c; smart00478
76869002465	minor groove reading motif; other site
76869002466	helix-hairpin-helix signature motif; other site
76869002467	substrate binding pocket [chemical binding]; other site
76869002468	active site
76869002469	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
76869002470	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
76869002471	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869002472	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
76869002473	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
76869002474	DNA binding site [nucleotide binding]
76869002475	active site
76869002476	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
76869002477	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
76869002478	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869002479	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869002480	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
76869002481	NAD(P) binding site [chemical binding]; other site
76869002482	catalytic residues [active]
76869002483	catalytic residues [active]
76869002484	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
76869002485	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869002486	Na binding site [ion binding]; other site
76869002487	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
76869002488	SnoaL-like domain; Region: SnoaL_3; pfam13474
76869002489	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869002490	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002491	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869002492	DNA binding residues [nucleotide binding]
76869002493	fec operon regulator FecR; Reviewed; Region: PRK09774
76869002494	FecR protein; Region: FecR; pfam04773
76869002495	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002496	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
76869002497	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002498	N-terminal plug; other site
76869002499	ligand-binding site [chemical binding]; other site
76869002500	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
76869002501	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
76869002502	Cl binding site [ion binding]; other site
76869002503	oligomer interface [polypeptide binding]; other site
76869002504	Isochorismatase family; Region: Isochorismatase; pfam00857
76869002505	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
76869002506	catalytic triad [active]
76869002507	dimer interface [polypeptide binding]; other site
76869002508	conserved cis-peptide bond; other site
76869002509	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
76869002510	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
76869002511	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
76869002512	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
76869002513	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
76869002514	multidrug resistance protein MdtN; Provisional; Region: PRK10476
76869002515	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869002516	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869002517	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
76869002518	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
76869002519	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
76869002520	Sulfate transporter family; Region: Sulfate_transp; pfam00916
76869002521	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
76869002522	RNA polymerase sigma factor; Provisional; Region: PRK12525
76869002523	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002524	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869002525	DNA binding residues [nucleotide binding]
76869002526	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869002527	FecR protein; Region: FecR; pfam04773
76869002528	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002529	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869002530	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002531	N-terminal plug; other site
76869002532	ligand-binding site [chemical binding]; other site
76869002533	Dynamin family; Region: Dynamin_N; pfam00350
76869002534	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
76869002535	G3 box; other site
76869002536	Switch II region; other site
76869002537	GTP-binding protein YchF; Reviewed; Region: PRK09601
76869002538	YchF GTPase; Region: YchF; cd01900
76869002539	G1 box; other site
76869002540	GTP/Mg2+ binding site [chemical binding]; other site
76869002541	Switch I region; other site
76869002542	G2 box; other site
76869002543	Switch II region; other site
76869002544	G3 box; other site
76869002545	G4 box; other site
76869002546	G5 box; other site
76869002547	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
76869002548	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
76869002549	putative active site [active]
76869002550	catalytic residue [active]
76869002551	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
76869002552	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
76869002553	5S rRNA interface [nucleotide binding]; other site
76869002554	CTC domain interface [polypeptide binding]; other site
76869002555	L16 interface [polypeptide binding]; other site
76869002556	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
76869002557	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
76869002558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869002559	active site
76869002560	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
76869002561	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
76869002562	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
76869002563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869002564	TPR motif; other site
76869002565	binding surface
76869002566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
76869002567	binding surface
76869002568	TPR motif; other site
76869002569	TPR repeat; Region: TPR_11; pfam13414
76869002570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869002571	binding surface
76869002572	TPR motif; other site
76869002573	Protein of unknown function (DUF796); Region: DUF796; pfam05638
76869002574	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
76869002575	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
76869002576	tRNA; other site
76869002577	putative tRNA binding site [nucleotide binding]; other site
76869002578	putative NADP binding site [chemical binding]; other site
76869002579	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
76869002580	peptide chain release factor 1; Validated; Region: prfA; PRK00591
76869002581	This domain is found in peptide chain release factors; Region: PCRF; smart00937
76869002582	RF-1 domain; Region: RF-1; pfam00472
76869002583	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
76869002584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869002585	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
76869002586	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
76869002587	ATP binding site [chemical binding]; other site
76869002588	substrate interface [chemical binding]; other site
76869002589	glutamate racemase; Provisional; Region: PRK00865
76869002590	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
76869002591	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869002592	NAD(P) binding site [chemical binding]; other site
76869002593	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
76869002594	DNA photolyase; Region: DNA_photolyase; pfam00875
76869002595	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
76869002596	DNA binding residues [nucleotide binding]
76869002597	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
76869002598	B12 binding domain; Region: B12-binding_2; pfam02607
76869002599	Protein of unknown function (DUF523); Region: DUF523; pfam04463
76869002600	Uncharacterized conserved protein [Function unknown]; Region: COG3272
76869002601	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
76869002602	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869002603	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
76869002604	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
76869002605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869002606	NAD(P) binding site [chemical binding]; other site
76869002607	active site
76869002608	ferrochelatase; Reviewed; Region: hemH; PRK00035
76869002609	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
76869002610	C-terminal domain interface [polypeptide binding]; other site
76869002611	active site
76869002612	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
76869002613	active site
76869002614	N-terminal domain interface [polypeptide binding]; other site
76869002615	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
76869002616	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869002617	active site
76869002618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869002619	active site
76869002620	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
76869002621	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
76869002622	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
76869002623	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
76869002624	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
76869002625	putative acyl-acceptor binding pocket; other site
76869002626	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
76869002627	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
76869002628	Uncharacterized conserved protein [Function unknown]; Region: COG2135
76869002629	Peptidase family M48; Region: Peptidase_M48; pfam01435
76869002630	Predicted membrane protein [Function unknown]; Region: COG2119
76869002631	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
76869002632	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
76869002633	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
76869002634	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
76869002635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869002636	S-adenosylmethionine binding site [chemical binding]; other site
76869002637	glycerate dehydrogenase; Provisional; Region: PRK06487
76869002638	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
76869002639	putative ligand binding site [chemical binding]; other site
76869002640	putative NAD binding site [chemical binding]; other site
76869002641	catalytic site [active]
76869002642	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
76869002643	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
76869002644	acyl-activating enzyme (AAE) consensus motif; other site
76869002645	AMP binding site [chemical binding]; other site
76869002646	active site
76869002647	CoA binding site [chemical binding]; other site
76869002648	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
76869002649	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
76869002650	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
76869002651	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869002652	DNA binding residues [nucleotide binding]
76869002653	dimerization interface [polypeptide binding]; other site
76869002654	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
76869002655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869002656	active site
76869002657	phosphorylation site [posttranslational modification]
76869002658	intermolecular recognition site; other site
76869002659	dimerization interface [polypeptide binding]; other site
76869002660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869002661	binding surface
76869002662	TPR motif; other site
76869002663	TPR repeat; Region: TPR_11; pfam13414
76869002664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
76869002665	binding surface
76869002666	TPR motif; other site
76869002667	TPR repeat; Region: TPR_11; pfam13414
76869002668	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869002669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869002670	ATP binding site [chemical binding]; other site
76869002671	Mg2+ binding site [ion binding]; other site
76869002672	G-X-G motif; other site
76869002673	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
76869002674	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
76869002675	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869002676	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869002677	ligand binding site [chemical binding]; other site
76869002678	phosphate acetyltransferase; Reviewed; Region: PRK05632
76869002679	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
76869002680	DRTGG domain; Region: DRTGG; pfam07085
76869002681	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
76869002682	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
76869002683	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
76869002684	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869002685	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
76869002686	catalytic residues [active]
76869002687	dimer interface [polypeptide binding]; other site
76869002688	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
76869002689	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869002690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869002691	PAS domain; Region: PAS_9; pfam13426
76869002692	putative active site [active]
76869002693	heme pocket [chemical binding]; other site
76869002694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869002695	PAS domain; Region: PAS_9; pfam13426
76869002696	putative active site [active]
76869002697	heme pocket [chemical binding]; other site
76869002698	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869002699	dimer interface [polypeptide binding]; other site
76869002700	putative CheW interface [polypeptide binding]; other site
76869002701	putative sulfate transport protein CysZ; Validated; Region: PRK04949
76869002702	thioredoxin reductase; Provisional; Region: PRK10262
76869002703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869002704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869002705	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
76869002706	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
76869002707	dimerization interface [polypeptide binding]; other site
76869002708	active site
76869002709	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
76869002710	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
76869002711	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
76869002712	amidase catalytic site [active]
76869002713	Zn binding residues [ion binding]; other site
76869002714	substrate binding site [chemical binding]; other site
76869002715	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
76869002716	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
76869002717	active site
76869002718	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
76869002719	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
76869002720	DNA binding site [nucleotide binding]
76869002721	domain linker motif; other site
76869002722	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
76869002723	dimerization interface [polypeptide binding]; other site
76869002724	ligand binding site [chemical binding]; other site
76869002725	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
76869002726	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
76869002727	active site
76869002728	phosphorylation site [posttranslational modification]
76869002729	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
76869002730	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
76869002731	dimerization domain swap beta strand [polypeptide binding]; other site
76869002732	regulatory protein interface [polypeptide binding]; other site
76869002733	active site
76869002734	regulatory phosphorylation site [posttranslational modification]; other site
76869002735	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
76869002736	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
76869002737	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
76869002738	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
76869002739	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
76869002740	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
76869002741	putative substrate binding site [chemical binding]; other site
76869002742	putative ATP binding site [chemical binding]; other site
76869002743	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
76869002744	active site
76869002745	P-loop; other site
76869002746	phosphorylation site [posttranslational modification]
76869002747	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
76869002748	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
76869002749	active site
76869002750	P-loop; other site
76869002751	phosphorylation site [posttranslational modification]
76869002752	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
76869002753	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
76869002754	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
76869002755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869002756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869002757	metal binding site [ion binding]; metal-binding site
76869002758	active site
76869002759	I-site; other site
76869002760	outer membrane porin, OprD family; Region: OprD; pfam03573
76869002761	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
76869002762	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869002763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869002764	dimer interface [polypeptide binding]; other site
76869002765	phosphorylation site [posttranslational modification]
76869002766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869002767	ATP binding site [chemical binding]; other site
76869002768	G-X-G motif; other site
76869002769	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
76869002770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869002771	active site
76869002772	phosphorylation site [posttranslational modification]
76869002773	intermolecular recognition site; other site
76869002774	dimerization interface [polypeptide binding]; other site
76869002775	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869002776	DNA binding site [nucleotide binding]
76869002777	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
76869002778	Protein export membrane protein; Region: SecD_SecF; cl14618
76869002779	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869002780	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869002781	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869002782	Flagellin N-methylase; Region: FliB; pfam03692
76869002783	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
76869002784	Response regulator receiver domain; Region: Response_reg; pfam00072
76869002785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869002786	active site
76869002787	phosphorylation site [posttranslational modification]
76869002788	intermolecular recognition site; other site
76869002789	dimerization interface [polypeptide binding]; other site
76869002790	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
76869002791	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869002792	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869002793	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
76869002794	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869002795	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869002796	Walker A/P-loop; other site
76869002797	ATP binding site [chemical binding]; other site
76869002798	Q-loop/lid; other site
76869002799	ABC transporter signature motif; other site
76869002800	Walker B; other site
76869002801	D-loop; other site
76869002802	H-loop/switch region; other site
76869002803	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
76869002804	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
76869002805	GAF domain; Region: GAF; pfam01590
76869002806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869002807	Walker A motif; other site
76869002808	ATP binding site [chemical binding]; other site
76869002809	Walker B motif; other site
76869002810	arginine finger; other site
76869002811	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
76869002812	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
76869002813	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
76869002814	heme-binding site [chemical binding]; other site
76869002815	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
76869002816	FAD binding pocket [chemical binding]; other site
76869002817	FAD binding motif [chemical binding]; other site
76869002818	phosphate binding motif [ion binding]; other site
76869002819	beta-alpha-beta structure motif; other site
76869002820	NAD binding pocket [chemical binding]; other site
76869002821	Heme binding  pocket [chemical binding]; other site
76869002822	disulfide bond formation protein B; Provisional; Region: PRK02110
76869002823	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
76869002824	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
76869002825	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
76869002826	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
76869002827	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
76869002828	D-pathway; other site
76869002829	Putative ubiquinol binding site [chemical binding]; other site
76869002830	Low-spin heme (heme b) binding site [chemical binding]; other site
76869002831	Putative water exit pathway; other site
76869002832	Binuclear center (heme o3/CuB) [ion binding]; other site
76869002833	K-pathway; other site
76869002834	Putative proton exit pathway; other site
76869002835	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
76869002836	Subunit I/III interface [polypeptide binding]; other site
76869002837	Subunit III/IV interface [polypeptide binding]; other site
76869002838	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
76869002839	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
76869002840	UbiA prenyltransferase family; Region: UbiA; pfam01040
76869002841	aminotransferase; Validated; Region: PRK08175
76869002842	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869002843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869002844	homodimer interface [polypeptide binding]; other site
76869002845	catalytic residue [active]
76869002846	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
76869002847	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
76869002848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869002849	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869002850	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002851	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869002852	DNA binding residues [nucleotide binding]
76869002853	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869002854	FecR protein; Region: FecR; pfam04773
76869002855	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002856	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869002857	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002858	N-terminal plug; other site
76869002859	ligand-binding site [chemical binding]; other site
76869002860	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
76869002861	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
76869002862	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
76869002863	active site residue [active]
76869002864	selenophosphate synthetase; Provisional; Region: PRK00943
76869002865	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
76869002866	dimerization interface [polypeptide binding]; other site
76869002867	putative ATP binding site [chemical binding]; other site
76869002868	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
76869002869	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869002870	substrate binding pocket [chemical binding]; other site
76869002871	membrane-bound complex binding site; other site
76869002872	hinge residues; other site
76869002873	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
76869002874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869002875	Walker A/P-loop; other site
76869002876	ATP binding site [chemical binding]; other site
76869002877	Q-loop/lid; other site
76869002878	ABC transporter signature motif; other site
76869002879	Walker B; other site
76869002880	D-loop; other site
76869002881	H-loop/switch region; other site
76869002882	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
76869002883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869002884	dimer interface [polypeptide binding]; other site
76869002885	conserved gate region; other site
76869002886	putative PBP binding loops; other site
76869002887	ABC-ATPase subunit interface; other site
76869002888	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
76869002889	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
76869002890	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
76869002891	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869002892	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869002893	Coenzyme A binding pocket [chemical binding]; other site
76869002894	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
76869002895	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869002896	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869002897	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869002898	fec operon regulator FecR; Reviewed; Region: PRK09774
76869002899	FecR protein; Region: FecR; pfam04773
76869002900	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869002901	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869002902	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869002903	N-terminal plug; other site
76869002904	ligand-binding site [chemical binding]; other site
76869002905	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
76869002906	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
76869002907	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
76869002908	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
76869002909	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
76869002910	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
76869002911	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
76869002912	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
76869002913	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
76869002914	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
76869002915	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
76869002916	Protein export membrane protein; Region: SecD_SecF; pfam02355
76869002917	hypothetical protein; Provisional; Region: PRK11280
76869002918	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
76869002919	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
76869002920	active site
76869002921	dimerization interface [polypeptide binding]; other site
76869002922	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
76869002923	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
76869002924	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
76869002925	serine O-acetyltransferase; Region: cysE; TIGR01172
76869002926	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
76869002927	trimer interface [polypeptide binding]; other site
76869002928	active site
76869002929	substrate binding site [chemical binding]; other site
76869002930	CoA binding site [chemical binding]; other site
76869002931	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
76869002932	Rrf2 family protein; Region: rrf2_super; TIGR00738
76869002933	cysteine desulfurase; Provisional; Region: PRK14012
76869002934	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
76869002935	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869002936	catalytic residue [active]
76869002937	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
76869002938	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
76869002939	trimerization site [polypeptide binding]; other site
76869002940	active site
76869002941	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
76869002942	co-chaperone HscB; Provisional; Region: hscB; PRK00294
76869002943	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
76869002944	HSP70 interaction site [polypeptide binding]; other site
76869002945	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
76869002946	chaperone protein HscA; Provisional; Region: hscA; PRK05183
76869002947	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
76869002948	nucleotide binding site [chemical binding]; other site
76869002949	putative NEF/HSP70 interaction site [polypeptide binding]; other site
76869002950	SBD interface [polypeptide binding]; other site
76869002951	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
76869002952	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869002953	catalytic loop [active]
76869002954	iron binding site [ion binding]; other site
76869002955	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
76869002956	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
76869002957	active site
76869002958	multimer interface [polypeptide binding]; other site
76869002959	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
76869002960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869002961	FeS/SAM binding site; other site
76869002962	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
76869002963	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869002964	TPR motif; other site
76869002965	binding surface
76869002966	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
76869002967	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869002968	non-specific DNA binding site [nucleotide binding]; other site
76869002969	salt bridge; other site
76869002970	sequence-specific DNA binding site [nucleotide binding]; other site
76869002971	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
76869002972	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
76869002973	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
76869002974	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
76869002975	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
76869002976	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
76869002977	dimer interface [polypeptide binding]; other site
76869002978	motif 1; other site
76869002979	active site
76869002980	motif 2; other site
76869002981	motif 3; other site
76869002982	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
76869002983	anticodon binding site; other site
76869002984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
76869002985	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
76869002986	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
76869002987	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
76869002988	Trp docking motif [polypeptide binding]; other site
76869002989	active site
76869002990	GTP-binding protein Der; Reviewed; Region: PRK00093
76869002991	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
76869002992	G1 box; other site
76869002993	GTP/Mg2+ binding site [chemical binding]; other site
76869002994	Switch I region; other site
76869002995	G2 box; other site
76869002996	Switch II region; other site
76869002997	G3 box; other site
76869002998	G4 box; other site
76869002999	G5 box; other site
76869003000	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
76869003001	G1 box; other site
76869003002	GTP/Mg2+ binding site [chemical binding]; other site
76869003003	Switch I region; other site
76869003004	G2 box; other site
76869003005	G3 box; other site
76869003006	Switch II region; other site
76869003007	G4 box; other site
76869003008	G5 box; other site
76869003009	methionine aminotransferase; Validated; Region: PRK09082
76869003010	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869003011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869003012	homodimer interface [polypeptide binding]; other site
76869003013	catalytic residue [active]
76869003014	C-N hydrolase family amidase; Provisional; Region: PRK10438
76869003015	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
76869003016	putative active site [active]
76869003017	catalytic triad [active]
76869003018	dimer interface [polypeptide binding]; other site
76869003019	multimer interface [polypeptide binding]; other site
76869003020	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
76869003021	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
76869003022	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
76869003023	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
76869003024	Flavodoxin; Region: Flavodoxin_1; pfam00258
76869003025	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
76869003026	FAD binding pocket [chemical binding]; other site
76869003027	FAD binding motif [chemical binding]; other site
76869003028	catalytic residues [active]
76869003029	NAD binding pocket [chemical binding]; other site
76869003030	phosphate binding motif [ion binding]; other site
76869003031	beta-alpha-beta structure motif; other site
76869003032	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
76869003033	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869003034	N-terminal plug; other site
76869003035	ligand-binding site [chemical binding]; other site
76869003036	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
76869003037	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
76869003038	Sel1 repeat; Region: Sel1; cl02723
76869003039	Sel1-like repeats; Region: SEL1; smart00671
76869003040	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
76869003041	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
76869003042	dimer interface [polypeptide binding]; other site
76869003043	active site
76869003044	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869003045	catalytic residues [active]
76869003046	substrate binding site [chemical binding]; other site
76869003047	RNA polymerase sigma factor; Reviewed; Region: PRK12527
76869003048	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869003049	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869003050	DNA binding residues [nucleotide binding]
76869003051	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869003052	FecR protein; Region: FecR; pfam04773
76869003053	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
76869003054	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869003055	N-terminal plug; other site
76869003056	ligand-binding site [chemical binding]; other site
76869003057	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
76869003058	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
76869003059	Walker A/P-loop; other site
76869003060	ATP binding site [chemical binding]; other site
76869003061	Q-loop/lid; other site
76869003062	ABC transporter signature motif; other site
76869003063	Walker B; other site
76869003064	D-loop; other site
76869003065	H-loop/switch region; other site
76869003066	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
76869003067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003068	dimer interface [polypeptide binding]; other site
76869003069	conserved gate region; other site
76869003070	ABC-ATPase subunit interface; other site
76869003071	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
76869003072	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
76869003073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003074	dimer interface [polypeptide binding]; other site
76869003075	conserved gate region; other site
76869003076	putative PBP binding loops; other site
76869003077	ABC-ATPase subunit interface; other site
76869003078	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
76869003079	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
76869003080	G1 box; other site
76869003081	putative GEF interaction site [polypeptide binding]; other site
76869003082	GTP/Mg2+ binding site [chemical binding]; other site
76869003083	Switch I region; other site
76869003084	G2 box; other site
76869003085	G3 box; other site
76869003086	Switch II region; other site
76869003087	G4 box; other site
76869003088	G5 box; other site
76869003089	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
76869003090	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869003091	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869003092	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
76869003093	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869003094	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869003095	SnoaL-like domain; Region: SnoaL_2; pfam12680
76869003096	Helix-turn-helix domain; Region: HTH_18; pfam12833
76869003097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869003098	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
76869003099	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869003100	Walker A/P-loop; other site
76869003101	ATP binding site [chemical binding]; other site
76869003102	Q-loop/lid; other site
76869003103	ABC transporter signature motif; other site
76869003104	Walker B; other site
76869003105	D-loop; other site
76869003106	H-loop/switch region; other site
76869003107	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
76869003108	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
76869003109	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869003110	Walker A/P-loop; other site
76869003111	ATP binding site [chemical binding]; other site
76869003112	Q-loop/lid; other site
76869003113	ABC transporter signature motif; other site
76869003114	Walker B; other site
76869003115	D-loop; other site
76869003116	H-loop/switch region; other site
76869003117	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
76869003118	dipeptide transporter; Provisional; Region: PRK10913
76869003119	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
76869003120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003121	dimer interface [polypeptide binding]; other site
76869003122	conserved gate region; other site
76869003123	putative PBP binding loops; other site
76869003124	ABC-ATPase subunit interface; other site
76869003125	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
76869003126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003127	dimer interface [polypeptide binding]; other site
76869003128	conserved gate region; other site
76869003129	putative PBP binding loops; other site
76869003130	ABC-ATPase subunit interface; other site
76869003131	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
76869003132	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
76869003133	peptide binding site [polypeptide binding]; other site
76869003134	outer membrane porin, OprD family; Region: OprD; pfam03573
76869003135	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
76869003136	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
76869003137	peptide binding site [polypeptide binding]; other site
76869003138	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
76869003139	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
76869003140	peptide binding site [polypeptide binding]; other site
76869003141	Protein of unknown function (DUF541); Region: SIMPL; cl01077
76869003142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869003143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869003144	ATP binding site [chemical binding]; other site
76869003145	G-X-G motif; other site
76869003146	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
76869003147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869003148	active site
76869003149	phosphorylation site [posttranslational modification]
76869003150	intermolecular recognition site; other site
76869003151	dimerization interface [polypeptide binding]; other site
76869003152	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869003153	Predicted permeases [General function prediction only]; Region: COG0679
76869003154	aromatic amino acid transporter; Provisional; Region: PRK10238
76869003155	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
76869003156	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
76869003157	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
76869003158	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
76869003159	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
76869003160	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
76869003161	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
76869003162	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
76869003163	GatB domain; Region: GatB_Yqey; smart00845
76869003164	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
76869003165	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
76869003166	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
76869003167	rod shape-determining protein MreB; Provisional; Region: PRK13927
76869003168	MreB and similar proteins; Region: MreB_like; cd10225
76869003169	nucleotide binding site [chemical binding]; other site
76869003170	Mg binding site [ion binding]; other site
76869003171	putative protofilament interaction site [polypeptide binding]; other site
76869003172	RodZ interaction site [polypeptide binding]; other site
76869003173	rod shape-determining protein MreC; Provisional; Region: PRK13922
76869003174	rod shape-determining protein MreC; Region: MreC; pfam04085
76869003175	rod shape-determining protein MreD; Region: MreD; cl01087
76869003176	Maf-like protein; Region: Maf; pfam02545
76869003177	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
76869003178	active site
76869003179	dimer interface [polypeptide binding]; other site
76869003180	ribonuclease G; Provisional; Region: PRK11712
76869003181	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
76869003182	homodimer interface [polypeptide binding]; other site
76869003183	oligonucleotide binding site [chemical binding]; other site
76869003184	TIGR02099 family protein; Region: TIGR02099
76869003185	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
76869003186	nitrilase; Region: PLN02798
76869003187	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
76869003188	putative active site [active]
76869003189	catalytic triad [active]
76869003190	dimer interface [polypeptide binding]; other site
76869003191	protease TldD; Provisional; Region: tldD; PRK10735
76869003192	hypothetical protein; Provisional; Region: PRK05255
76869003193	peptidase PmbA; Provisional; Region: PRK11040
76869003194	fumarate hydratase; Reviewed; Region: fumC; PRK00485
76869003195	Class II fumarases; Region: Fumarase_classII; cd01362
76869003196	active site
76869003197	tetramer interface [polypeptide binding]; other site
76869003198	Protein of unknown function (DUF2753); Region: DUF2753; pfam10952
76869003199	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
76869003200	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
76869003201	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
76869003202	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
76869003203	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
76869003204	dimerization domain swap beta strand [polypeptide binding]; other site
76869003205	regulatory protein interface [polypeptide binding]; other site
76869003206	active site
76869003207	regulatory phosphorylation site [posttranslational modification]; other site
76869003208	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
76869003209	AAA domain; Region: AAA_18; pfam13238
76869003210	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
76869003211	active site
76869003212	phosphorylation site [posttranslational modification]
76869003213	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
76869003214	30S subunit binding site; other site
76869003215	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
76869003216	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
76869003217	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
76869003218	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
76869003219	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
76869003220	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
76869003221	Walker A/P-loop; other site
76869003222	ATP binding site [chemical binding]; other site
76869003223	Q-loop/lid; other site
76869003224	ABC transporter signature motif; other site
76869003225	Walker B; other site
76869003226	D-loop; other site
76869003227	H-loop/switch region; other site
76869003228	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
76869003229	OstA-like protein; Region: OstA; pfam03968
76869003230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
76869003231	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
76869003232	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
76869003233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869003234	active site
76869003235	motif I; other site
76869003236	motif II; other site
76869003237	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
76869003238	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
76869003239	putative active site [active]
76869003240	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
76869003241	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
76869003242	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
76869003243	Walker A/P-loop; other site
76869003244	ATP binding site [chemical binding]; other site
76869003245	Q-loop/lid; other site
76869003246	ABC transporter signature motif; other site
76869003247	Walker B; other site
76869003248	D-loop; other site
76869003249	H-loop/switch region; other site
76869003250	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
76869003251	Permease; Region: Permease; cl00510
76869003252	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
76869003253	mce related protein; Region: MCE; pfam02470
76869003254	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
76869003255	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
76869003256	anti sigma factor interaction site; other site
76869003257	regulatory phosphorylation site [posttranslational modification]; other site
76869003258	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
76869003259	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
76869003260	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
76869003261	hinge; other site
76869003262	active site
76869003263	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
76869003264	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
76869003265	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
76869003266	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
76869003267	NAD binding site [chemical binding]; other site
76869003268	dimerization interface [polypeptide binding]; other site
76869003269	product binding site; other site
76869003270	substrate binding site [chemical binding]; other site
76869003271	zinc binding site [ion binding]; other site
76869003272	catalytic residues [active]
76869003273	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
76869003274	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869003275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869003276	homodimer interface [polypeptide binding]; other site
76869003277	catalytic residue [active]
76869003278	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
76869003279	Sulfatase; Region: Sulfatase; cl17466
76869003280	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869003281	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869003282	DNA-binding site [nucleotide binding]; DNA binding site
76869003283	FCD domain; Region: FCD; pfam07729
76869003284	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
76869003285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869003286	SnoaL-like domain; Region: SnoaL_2; pfam12680
76869003287	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
76869003288	GIY-YIG motif/motif A; other site
76869003289	putative active site [active]
76869003290	putative metal binding site [ion binding]; other site
76869003291	Nucleoid-associated protein [General function prediction only]; Region: COG3081
76869003292	nucleoid-associated protein NdpA; Validated; Region: PRK00378
76869003293	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
76869003294	IHF - DNA interface [nucleotide binding]; other site
76869003295	IHF dimer interface [polypeptide binding]; other site
76869003296	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
76869003297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869003298	S-adenosylmethionine binding site [chemical binding]; other site
76869003299	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
76869003300	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
76869003301	HIGH motif; other site
76869003302	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
76869003303	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
76869003304	active site
76869003305	KMSKS motif; other site
76869003306	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
76869003307	tRNA binding surface [nucleotide binding]; other site
76869003308	anticodon binding site; other site
76869003309	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
76869003310	DNA polymerase III subunit chi; Validated; Region: PRK05728
76869003311	multifunctional aminopeptidase A; Provisional; Region: PRK00913
76869003312	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
76869003313	interface (dimer of trimers) [polypeptide binding]; other site
76869003314	Substrate-binding/catalytic site; other site
76869003315	Zn-binding sites [ion binding]; other site
76869003316	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
76869003317	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
76869003318	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
76869003319	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
76869003320	RDD family; Region: RDD; pfam06271
76869003321	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
76869003322	DNA-binding site [nucleotide binding]; DNA binding site
76869003323	RNA-binding motif; other site
76869003324	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
76869003325	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
76869003326	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
76869003327	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
76869003328	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
76869003329	glycine dehydrogenase; Provisional; Region: PRK05367
76869003330	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
76869003331	tetramer interface [polypeptide binding]; other site
76869003332	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869003333	catalytic residue [active]
76869003334	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
76869003335	tetramer interface [polypeptide binding]; other site
76869003336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869003337	catalytic residue [active]
76869003338	glycine cleavage system protein H; Provisional; Region: PRK13380
76869003339	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
76869003340	lipoyl attachment site [posttranslational modification]; other site
76869003341	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
76869003342	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
76869003343	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
76869003344	putative aromatic amino acid binding site; other site
76869003345	PAS domain; Region: PAS; smart00091
76869003346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869003347	Walker A motif; other site
76869003348	ATP binding site [chemical binding]; other site
76869003349	Walker B motif; other site
76869003350	arginine finger; other site
76869003351	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
76869003352	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
76869003353	putative substrate binding site [chemical binding]; other site
76869003354	nucleotide binding site [chemical binding]; other site
76869003355	nucleotide binding site [chemical binding]; other site
76869003356	homodimer interface [polypeptide binding]; other site
76869003357	ornithine carbamoyltransferase; Validated; Region: PRK02102
76869003358	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
76869003359	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
76869003360	arginine deiminase; Provisional; Region: PRK01388
76869003361	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
76869003362	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
76869003363	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
76869003364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
76869003365	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
76869003366	heme binding pocket [chemical binding]; other site
76869003367	heme ligand [chemical binding]; other site
76869003368	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869003369	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
76869003370	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869003371	N-terminal plug; other site
76869003372	ligand-binding site [chemical binding]; other site
76869003373	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869003374	FecR protein; Region: FecR; pfam04773
76869003375	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
76869003376	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869003377	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869003378	DNA binding residues [nucleotide binding]
76869003379	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
76869003380	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
76869003381	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
76869003382	phosphogluconate dehydratase; Validated; Region: PRK09054
76869003383	6-phosphogluconate dehydratase; Region: edd; TIGR01196
76869003384	glucokinase; Provisional; Region: glk; PRK00292
76869003385	glucokinase, proteobacterial type; Region: glk; TIGR00749
76869003386	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869003387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869003388	active site
76869003389	phosphorylation site [posttranslational modification]
76869003390	intermolecular recognition site; other site
76869003391	dimerization interface [polypeptide binding]; other site
76869003392	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869003393	DNA binding site [nucleotide binding]
76869003394	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869003395	dimerization interface [polypeptide binding]; other site
76869003396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869003397	ATP binding site [chemical binding]; other site
76869003398	Mg2+ binding site [ion binding]; other site
76869003399	G-X-G motif; other site
76869003400	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
76869003401	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
76869003402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003403	dimer interface [polypeptide binding]; other site
76869003404	conserved gate region; other site
76869003405	putative PBP binding loops; other site
76869003406	ABC-ATPase subunit interface; other site
76869003407	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
76869003408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003409	dimer interface [polypeptide binding]; other site
76869003410	conserved gate region; other site
76869003411	putative PBP binding loops; other site
76869003412	ABC-ATPase subunit interface; other site
76869003413	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
76869003414	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
76869003415	Walker A/P-loop; other site
76869003416	ATP binding site [chemical binding]; other site
76869003417	Q-loop/lid; other site
76869003418	ABC transporter signature motif; other site
76869003419	Walker B; other site
76869003420	D-loop; other site
76869003421	H-loop/switch region; other site
76869003422	TOBE domain; Region: TOBE_2; pfam08402
76869003423	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
76869003424	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
76869003425	active site
76869003426	phosphate binding residues; other site
76869003427	catalytic residues [active]
76869003428	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
76869003429	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
76869003430	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
76869003431	putative active site [active]
76869003432	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
76869003433	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
76869003434	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
76869003435	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
76869003436	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
76869003437	putative active site [active]
76869003438	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
76869003439	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
76869003440	active site
76869003441	intersubunit interface [polypeptide binding]; other site
76869003442	catalytic residue [active]
76869003443	2-isopropylmalate synthase; Validated; Region: PRK03739
76869003444	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
76869003445	active site
76869003446	catalytic residues [active]
76869003447	metal binding site [ion binding]; metal-binding site
76869003448	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
76869003449	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
76869003450	Glypican; Region: Glypican; pfam01153
76869003451	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869003452	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
76869003453	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
76869003454	generic binding surface II; other site
76869003455	generic binding surface I; other site
76869003456	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869003457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869003458	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
76869003459	dimerization interface [polypeptide binding]; other site
76869003460	substrate binding pocket [chemical binding]; other site
76869003461	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869003462	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
76869003463	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
76869003464	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
76869003465	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
76869003466	active site
76869003467	GMP synthase; Reviewed; Region: guaA; PRK00074
76869003468	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
76869003469	AMP/PPi binding site [chemical binding]; other site
76869003470	candidate oxyanion hole; other site
76869003471	catalytic triad [active]
76869003472	potential glutamine specificity residues [chemical binding]; other site
76869003473	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
76869003474	ATP Binding subdomain [chemical binding]; other site
76869003475	Ligand Binding sites [chemical binding]; other site
76869003476	Dimerization subdomain; other site
76869003477	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
76869003478	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
76869003479	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
76869003480	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
76869003481	nucleoside/Zn binding site; other site
76869003482	dimer interface [polypeptide binding]; other site
76869003483	catalytic motif [active]
76869003484	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
76869003485	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869003486	substrate binding pocket [chemical binding]; other site
76869003487	membrane-bound complex binding site; other site
76869003488	hinge residues; other site
76869003489	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869003490	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869003491	catalytic residue [active]
76869003492	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
76869003493	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
76869003494	dimerization interface [polypeptide binding]; other site
76869003495	ATP binding site [chemical binding]; other site
76869003496	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
76869003497	dimerization interface [polypeptide binding]; other site
76869003498	ATP binding site [chemical binding]; other site
76869003499	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
76869003500	putative active site [active]
76869003501	catalytic triad [active]
76869003502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
76869003503	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
76869003504	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
76869003505	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
76869003506	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
76869003507	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
76869003508	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
76869003509	active site
76869003510	metal binding site [ion binding]; metal-binding site
76869003511	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
76869003512	type II secretion system protein D; Region: type_II_gspD; TIGR02517
76869003513	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
76869003514	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
76869003515	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
76869003516	type II secretion system protein E; Region: type_II_gspE; TIGR02533
76869003517	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
76869003518	Walker A motif; other site
76869003519	ATP binding site [chemical binding]; other site
76869003520	Walker B motif; other site
76869003521	type II secretion system protein F; Region: GspF; TIGR02120
76869003522	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
76869003523	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
76869003524	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
76869003525	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
76869003526	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
76869003527	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
76869003528	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
76869003529	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
76869003530	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
76869003531	type II secretion system protein J; Region: gspJ; TIGR01711
76869003532	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
76869003533	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
76869003534	GspL periplasmic domain; Region: GspL_C; pfam12693
76869003535	haemagglutination activity domain; Region: Haemagg_act; pfam05860
76869003536	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
76869003537	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
76869003538	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
76869003539	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
76869003540	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
76869003541	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
76869003542	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
76869003543	nudix motif; other site
76869003544	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
76869003545	putative active site [active]
76869003546	putative CoA binding site [chemical binding]; other site
76869003547	nudix motif; other site
76869003548	metal binding site [ion binding]; metal-binding site
76869003549	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
76869003550	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
76869003551	trimer interface [polypeptide binding]; other site
76869003552	putative metal binding site [ion binding]; other site
76869003553	Predicted Fe-S protein [General function prediction only]; Region: COG3313
76869003554	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
76869003555	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
76869003556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869003557	ATP-grasp domain; Region: ATP-grasp; pfam02222
76869003558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869003559	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869003560	putative substrate translocation pore; other site
76869003561	Domain of unknown function DUF21; Region: DUF21; pfam01595
76869003562	FOG: CBS domain [General function prediction only]; Region: COG0517
76869003563	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
76869003564	Transporter associated domain; Region: CorC_HlyC; smart01091
76869003565	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
76869003566	signal recognition particle protein; Provisional; Region: PRK10867
76869003567	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
76869003568	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
76869003569	P loop; other site
76869003570	GTP binding site [chemical binding]; other site
76869003571	Signal peptide binding domain; Region: SRP_SPB; pfam02978
76869003572	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
76869003573	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
76869003574	RimM N-terminal domain; Region: RimM; pfam01782
76869003575	PRC-barrel domain; Region: PRC; pfam05239
76869003576	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
76869003577	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
76869003578	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
76869003579	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
76869003580	TrkA-N domain; Region: TrkA_N; pfam02254
76869003581	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
76869003582	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
76869003583	active site
76869003584	Int/Topo IB signature motif; other site
76869003585	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
76869003586	dimerization domain [polypeptide binding]; other site
76869003587	dimer interface [polypeptide binding]; other site
76869003588	catalytic residues [active]
76869003589	homoserine dehydrogenase; Provisional; Region: PRK06349
76869003590	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
76869003591	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
76869003592	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
76869003593	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
76869003594	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
76869003595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869003596	catalytic residue [active]
76869003597	Response regulator receiver domain; Region: Response_reg; pfam00072
76869003598	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
76869003599	conserved hypothetical protein; Region: TIGR02285
76869003600	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
76869003601	CoA-transferase family III; Region: CoA_transf_3; pfam02515
76869003602	YaeQ protein; Region: YaeQ; pfam07152
76869003603	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
76869003604	DHH family; Region: DHH; pfam01368
76869003605	DHHA1 domain; Region: DHHA1; pfam02272
76869003606	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
76869003607	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
76869003608	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
76869003609	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
76869003610	active site
76869003611	FMN binding site [chemical binding]; other site
76869003612	substrate binding site [chemical binding]; other site
76869003613	homotetramer interface [polypeptide binding]; other site
76869003614	catalytic residue [active]
76869003615	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
76869003616	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
76869003617	tetrameric interface [polypeptide binding]; other site
76869003618	NAD binding site [chemical binding]; other site
76869003619	catalytic residues [active]
76869003620	substrate binding site [chemical binding]; other site
76869003621	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869003622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003623	dimer interface [polypeptide binding]; other site
76869003624	conserved gate region; other site
76869003625	ABC-ATPase subunit interface; other site
76869003626	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869003627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869003628	putative PBP binding loops; other site
76869003629	dimer interface [polypeptide binding]; other site
76869003630	ABC-ATPase subunit interface; other site
76869003631	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
76869003632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869003633	Walker A/P-loop; other site
76869003634	ATP binding site [chemical binding]; other site
76869003635	Q-loop/lid; other site
76869003636	ABC transporter signature motif; other site
76869003637	Walker B; other site
76869003638	D-loop; other site
76869003639	H-loop/switch region; other site
76869003640	TOBE domain; Region: TOBE_2; pfam08402
76869003641	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
76869003642	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869003643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
76869003644	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
76869003645	putative metal binding site [ion binding]; other site
76869003646	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
76869003647	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
76869003648	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869003649	dimerization interface [polypeptide binding]; other site
76869003650	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869003651	dimer interface [polypeptide binding]; other site
76869003652	putative CheW interface [polypeptide binding]; other site
76869003653	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
76869003654	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
76869003655	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
76869003656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869003657	S-adenosylmethionine binding site [chemical binding]; other site
76869003658	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
76869003659	CheW-like domain; Region: CheW; pfam01584
76869003660	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869003661	putative binding surface; other site
76869003662	active site
76869003663	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
76869003664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869003665	ATP binding site [chemical binding]; other site
76869003666	Mg2+ binding site [ion binding]; other site
76869003667	G-X-G motif; other site
76869003668	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
76869003669	Response regulator receiver domain; Region: Response_reg; pfam00072
76869003670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869003671	active site
76869003672	phosphorylation site [posttranslational modification]
76869003673	intermolecular recognition site; other site
76869003674	dimerization interface [polypeptide binding]; other site
76869003675	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
76869003676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869003677	active site
76869003678	phosphorylation site [posttranslational modification]
76869003679	intermolecular recognition site; other site
76869003680	CheB methylesterase; Region: CheB_methylest; pfam01339
76869003681	Response regulator receiver domain; Region: Response_reg; pfam00072
76869003682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869003683	active site
76869003684	phosphorylation site [posttranslational modification]
76869003685	intermolecular recognition site; other site
76869003686	dimerization interface [polypeptide binding]; other site
76869003687	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869003688	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869003689	metal binding site [ion binding]; metal-binding site
76869003690	active site
76869003691	I-site; other site
76869003692	peptide chain release factor 2; Provisional; Region: PRK08787
76869003693	This domain is found in peptide chain release factors; Region: PCRF; smart00937
76869003694	RF-1 domain; Region: RF-1; pfam00472
76869003695	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
76869003696	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
76869003697	dimer interface [polypeptide binding]; other site
76869003698	putative anticodon binding site; other site
76869003699	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
76869003700	motif 1; other site
76869003701	active site
76869003702	motif 2; other site
76869003703	motif 3; other site
76869003704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
76869003705	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
76869003706	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869003707	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869003708	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869003709	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869003710	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869003711	ligand binding site [chemical binding]; other site
76869003712	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
76869003713	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
76869003714	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
76869003715	adenylate kinase; Reviewed; Region: adk; PRK00279
76869003716	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
76869003717	AMP-binding site [chemical binding]; other site
76869003718	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
76869003719	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
76869003720	Glycoprotease family; Region: Peptidase_M22; pfam00814
76869003721	Protein of unknown function DUF72; Region: DUF72; cl00777
76869003722	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
76869003723	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
76869003724	tetramer interface [polypeptide binding]; other site
76869003725	active site
76869003726	Mg2+/Mn2+ binding site [ion binding]; other site
76869003727	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
76869003728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869003729	S-adenosylmethionine binding site [chemical binding]; other site
76869003730	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869003731	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869003732	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
76869003733	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869003734	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
76869003735	active site
76869003736	non-prolyl cis peptide bond; other site
76869003737	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
76869003738	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
76869003739	Flavin binding site [chemical binding]; other site
76869003740	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869003741	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869003742	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869003743	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
76869003744	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
76869003745	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
76869003746	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
76869003747	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
76869003748	putative acyl-acceptor binding pocket; other site
76869003749	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
76869003750	DNA-binding site [nucleotide binding]; DNA binding site
76869003751	RNA-binding motif; other site
76869003752	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
76869003753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869003754	S-adenosylmethionine binding site [chemical binding]; other site
76869003755	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
76869003756	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
76869003757	metal binding site [ion binding]; metal-binding site
76869003758	dimer interface [polypeptide binding]; other site
76869003759	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
76869003760	putative fimbrial chaperone protein; Provisional; Region: PRK09918
76869003761	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
76869003762	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
76869003763	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
76869003764	PapC N-terminal domain; Region: PapC_N; pfam13954
76869003765	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
76869003766	PapC C-terminal domain; Region: PapC_C; pfam13953
76869003767	hypothetical protein; Provisional; Region: PRK15301
76869003768	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
76869003769	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
76869003770	PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758
76869003771	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
76869003772	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
76869003773	active site
76869003774	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
76869003775	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
76869003776	putative ATP binding site [chemical binding]; other site
76869003777	putative substrate interface [chemical binding]; other site
76869003778	Fe-S metabolism associated domain; Region: SufE; cl00951
76869003779	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
76869003780	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
76869003781	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869003782	catalytic residue [active]
76869003783	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
76869003784	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
76869003785	putative trimer interface [polypeptide binding]; other site
76869003786	putative CoA binding site [chemical binding]; other site
76869003787	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
76869003788	ArsC family; Region: ArsC; pfam03960
76869003789	putative catalytic residues [active]
76869003790	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
76869003791	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
76869003792	Ca2+ binding site [ion binding]; other site
76869003793	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
76869003794	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869003795	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869003796	homodimer interface [polypeptide binding]; other site
76869003797	catalytic residue [active]
76869003798	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
76869003799	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
76869003800	metal binding triad; other site
76869003801	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
76869003802	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
76869003803	Zn2+ binding site [ion binding]; other site
76869003804	Mg2+ binding site [ion binding]; other site
76869003805	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
76869003806	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
76869003807	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
76869003808	active site
76869003809	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
76869003810	rRNA interaction site [nucleotide binding]; other site
76869003811	S8 interaction site; other site
76869003812	putative laminin-1 binding site; other site
76869003813	elongation factor Ts; Provisional; Region: tsf; PRK09377
76869003814	UBA/TS-N domain; Region: UBA; pfam00627
76869003815	Elongation factor TS; Region: EF_TS; pfam00889
76869003816	Elongation factor TS; Region: EF_TS; pfam00889
76869003817	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
76869003818	putative nucleotide binding site [chemical binding]; other site
76869003819	uridine monophosphate binding site [chemical binding]; other site
76869003820	homohexameric interface [polypeptide binding]; other site
76869003821	ribosome recycling factor; Reviewed; Region: frr; PRK00083
76869003822	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
76869003823	hinge region; other site
76869003824	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
76869003825	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
76869003826	catalytic residue [active]
76869003827	putative FPP diphosphate  binding site; other site
76869003828	putative FPP binding hydrophobic cleft; other site
76869003829	dimer interface [polypeptide binding]; other site
76869003830	putative IPP diphosphate binding site; other site
76869003831	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
76869003832	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
76869003833	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
76869003834	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
76869003835	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
76869003836	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
76869003837	zinc metallopeptidase RseP; Provisional; Region: PRK10779
76869003838	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
76869003839	active site
76869003840	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
76869003841	protein binding site [polypeptide binding]; other site
76869003842	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
76869003843	protein binding site [polypeptide binding]; other site
76869003844	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
76869003845	putative substrate binding region [chemical binding]; other site
76869003846	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
76869003847	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869003848	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869003849	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869003850	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869003851	Surface antigen; Region: Bac_surface_Ag; pfam01103
76869003852	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
76869003853	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
76869003854	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
76869003855	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
76869003856	trimer interface [polypeptide binding]; other site
76869003857	active site
76869003858	UDP-GlcNAc binding site [chemical binding]; other site
76869003859	lipid binding site [chemical binding]; lipid-binding site
76869003860	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
76869003861	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
76869003862	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
76869003863	active site
76869003864	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
76869003865	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
76869003866	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
76869003867	RNA/DNA hybrid binding site [nucleotide binding]; other site
76869003868	active site
76869003869	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
76869003870	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
76869003871	putative active site [active]
76869003872	putative PHP Thumb interface [polypeptide binding]; other site
76869003873	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
76869003874	generic binding surface II; other site
76869003875	generic binding surface I; other site
76869003876	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
76869003877	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
76869003878	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
76869003879	Ligand Binding Site [chemical binding]; other site
76869003880	TilS substrate binding domain; Region: TilS; pfam09179
76869003881	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
76869003882	CTP synthetase; Validated; Region: pyrG; PRK05380
76869003883	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
76869003884	Catalytic site [active]
76869003885	active site
76869003886	UTP binding site [chemical binding]; other site
76869003887	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
76869003888	active site
76869003889	putative oxyanion hole; other site
76869003890	catalytic triad [active]
76869003891	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
76869003892	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
76869003893	enolase; Provisional; Region: eno; PRK00077
76869003894	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
76869003895	dimer interface [polypeptide binding]; other site
76869003896	metal binding site [ion binding]; metal-binding site
76869003897	substrate binding pocket [chemical binding]; other site
76869003898	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
76869003899	Septum formation initiator; Region: DivIC; cl17659
76869003900	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
76869003901	substrate binding site; other site
76869003902	dimer interface; other site
76869003903	LysR family transcriptional regulator; Provisional; Region: PRK14997
76869003904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869003905	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
76869003906	putative effector binding pocket; other site
76869003907	putative dimerization interface [polypeptide binding]; other site
76869003908	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
76869003909	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
76869003910	substrate binding site [chemical binding]; other site
76869003911	catalytic Zn binding site [ion binding]; other site
76869003912	NAD binding site [chemical binding]; other site
76869003913	structural Zn binding site [ion binding]; other site
76869003914	dimer interface [polypeptide binding]; other site
76869003915	S-formylglutathione hydrolase; Region: PLN02442
76869003916	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
76869003917	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
76869003918	homotrimer interaction site [polypeptide binding]; other site
76869003919	zinc binding site [ion binding]; other site
76869003920	CDP-binding sites; other site
76869003921	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
76869003922	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
76869003923	Permutation of conserved domain; other site
76869003924	active site
76869003925	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
76869003926	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
76869003927	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
76869003928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869003929	S-adenosylmethionine binding site [chemical binding]; other site
76869003930	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
76869003931	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869003932	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
76869003933	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
76869003934	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869003935	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
76869003936	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869003937	DNA binding residues [nucleotide binding]
76869003938	Ferredoxin [Energy production and conversion]; Region: COG1146
76869003939	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
76869003940	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
76869003941	MutS domain I; Region: MutS_I; pfam01624
76869003942	MutS domain II; Region: MutS_II; pfam05188
76869003943	MutS domain III; Region: MutS_III; pfam05192
76869003944	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
76869003945	Walker A/P-loop; other site
76869003946	ATP binding site [chemical binding]; other site
76869003947	Q-loop/lid; other site
76869003948	ABC transporter signature motif; other site
76869003949	Walker B; other site
76869003950	D-loop; other site
76869003951	H-loop/switch region; other site
76869003952	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
76869003953	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
76869003954	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869003955	active site
76869003956	DNA binding site [nucleotide binding]
76869003957	Int/Topo IB signature motif; other site
76869003958	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
76869003959	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
76869003960	substrate interaction site [chemical binding]; other site
76869003961	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
76869003962	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869003963	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869003964	non-specific DNA binding site [nucleotide binding]; other site
76869003965	salt bridge; other site
76869003966	sequence-specific DNA binding site [nucleotide binding]; other site
76869003967	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869003968	Predicted transcriptional regulator [Transcription]; Region: COG2932
76869003969	Catalytic site [active]
76869003970	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
76869003971	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
76869003972	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
76869003973	polymerase nucleotide-binding site; other site
76869003974	DNA-binding residues [nucleotide binding]; DNA binding site
76869003975	nucleotide binding site [chemical binding]; other site
76869003976	primase nucleotide-binding site [nucleotide binding]; other site
76869003977	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
76869003978	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
76869003979	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
76869003980	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
76869003981	oligomer interface [polypeptide binding]; other site
76869003982	active site residues [active]
76869003983	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
76869003984	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
76869003985	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
76869003986	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
76869003987	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
76869003988	Baseplate J-like protein; Region: Baseplate_J; cl01294
76869003989	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
76869003990	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
76869003991	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
76869003992	Phage tail tube protein FII; Region: Phage_tube; pfam04985
76869003993	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
76869003994	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
76869003995	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
76869003996	Phage Tail Protein X; Region: Phage_tail_X; cl02088
76869003997	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
76869003998	Predicted chitinase [General function prediction only]; Region: COG3179
76869003999	catalytic residue [active]
76869004000	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
76869004001	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
76869004002	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
76869004003	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
76869004004	recombinase A; Provisional; Region: recA; PRK09354
76869004005	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
76869004006	hexamer interface [polypeptide binding]; other site
76869004007	Walker A motif; other site
76869004008	ATP binding site [chemical binding]; other site
76869004009	Walker B motif; other site
76869004010	recombination regulator RecX; Reviewed; Region: recX; PRK00117
76869004011	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
76869004012	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
76869004013	Uncharacterized conserved protein [Function unknown]; Region: COG3148
76869004014	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869004015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869004016	active site
76869004017	phosphorylation site [posttranslational modification]
76869004018	intermolecular recognition site; other site
76869004019	dimerization interface [polypeptide binding]; other site
76869004020	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869004021	DNA binding residues [nucleotide binding]
76869004022	dimerization interface [polypeptide binding]; other site
76869004023	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
76869004024	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
76869004025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004026	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
76869004027	putative dimerization interface [polypeptide binding]; other site
76869004028	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
76869004029	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
76869004030	FAD binding pocket [chemical binding]; other site
76869004031	FAD binding motif [chemical binding]; other site
76869004032	phosphate binding motif [ion binding]; other site
76869004033	beta-alpha-beta structure motif; other site
76869004034	NAD binding pocket [chemical binding]; other site
76869004035	hypothetical protein; Provisional; Region: PRK04860
76869004036	SprT homologues; Region: SprT; cl01182
76869004037	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
76869004038	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
76869004039	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
76869004040	Ligand Binding Site [chemical binding]; other site
76869004041	3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818
76869004042	Predicted membrane protein [Function unknown]; Region: COG3308
76869004043	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
76869004044	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869004045	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
76869004046	ArsC family; Region: ArsC; pfam03960
76869004047	catalytic residues [active]
76869004048	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
76869004049	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869004050	catalytic residues [active]
76869004051	META domain; Region: META; pfam03724
76869004052	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
76869004053	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
76869004054	putative ligand binding site [chemical binding]; other site
76869004055	putative NAD binding site [chemical binding]; other site
76869004056	catalytic site [active]
76869004057	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
76869004058	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869004059	dimerization interface [polypeptide binding]; other site
76869004060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869004061	dimer interface [polypeptide binding]; other site
76869004062	phosphorylation site [posttranslational modification]
76869004063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869004064	ATP binding site [chemical binding]; other site
76869004065	Mg2+ binding site [ion binding]; other site
76869004066	G-X-G motif; other site
76869004067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869004068	active site
76869004069	phosphorylation site [posttranslational modification]
76869004070	intermolecular recognition site; other site
76869004071	dimerization interface [polypeptide binding]; other site
76869004072	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869004073	putative binding surface; other site
76869004074	active site
76869004075	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869004076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869004077	active site
76869004078	phosphorylation site [posttranslational modification]
76869004079	intermolecular recognition site; other site
76869004080	dimerization interface [polypeptide binding]; other site
76869004081	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869004082	DNA binding site [nucleotide binding]
76869004083	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869004084	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869004085	dimerization interface [polypeptide binding]; other site
76869004086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869004087	dimer interface [polypeptide binding]; other site
76869004088	phosphorylation site [posttranslational modification]
76869004089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869004090	ATP binding site [chemical binding]; other site
76869004091	Mg2+ binding site [ion binding]; other site
76869004092	G-X-G motif; other site
76869004093	cysteine synthase B; Region: cysM; TIGR01138
76869004094	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
76869004095	dimer interface [polypeptide binding]; other site
76869004096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004097	catalytic residue [active]
76869004098	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
76869004099	TRAM domain; Region: TRAM; pfam01938
76869004100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869004101	S-adenosylmethionine binding site [chemical binding]; other site
76869004102	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
76869004103	HD domain; Region: HD_4; pfam13328
76869004104	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
76869004105	synthetase active site [active]
76869004106	NTP binding site [chemical binding]; other site
76869004107	metal binding site [ion binding]; metal-binding site
76869004108	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
76869004109	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
76869004110	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
76869004111	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
76869004112	homodimer interface [polypeptide binding]; other site
76869004113	metal binding site [ion binding]; metal-binding site
76869004114	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
76869004115	homodimer interface [polypeptide binding]; other site
76869004116	active site
76869004117	putative chemical substrate binding site [chemical binding]; other site
76869004118	metal binding site [ion binding]; metal-binding site
76869004119	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
76869004120	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
76869004121	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
76869004122	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
76869004123	active site
76869004124	substrate binding site [chemical binding]; other site
76869004125	cosubstrate binding site; other site
76869004126	catalytic site [active]
76869004127	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
76869004128	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
76869004129	dimerization interface [polypeptide binding]; other site
76869004130	putative ATP binding site [chemical binding]; other site
76869004131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
76869004132	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
76869004133	Domain of unknown function DUF20; Region: UPF0118; pfam01594
76869004134	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
76869004135	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
76869004136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869004137	Walker A motif; other site
76869004138	ATP binding site [chemical binding]; other site
76869004139	Walker B motif; other site
76869004140	arginine finger; other site
76869004141	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
76869004142	NlpC/P60 family; Region: NLPC_P60; pfam00877
76869004143	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
76869004144	NlpC/P60 family; Region: NLPC_P60; pfam00877
76869004145	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
76869004146	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
76869004147	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
76869004148	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
76869004149	Walker A motif; other site
76869004150	homodimer interface [polypeptide binding]; other site
76869004151	ATP binding site [chemical binding]; other site
76869004152	hydroxycobalamin binding site [chemical binding]; other site
76869004153	Walker B motif; other site
76869004154	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
76869004155	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
76869004156	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
76869004157	catalytic triad [active]
76869004158	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
76869004159	FMN binding site [chemical binding]; other site
76869004160	dimer interface [polypeptide binding]; other site
76869004161	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
76869004162	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
76869004163	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869004164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004165	homodimer interface [polypeptide binding]; other site
76869004166	catalytic residue [active]
76869004167	cobyric acid synthase; Provisional; Region: PRK00784
76869004168	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
76869004169	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
76869004170	catalytic triad [active]
76869004171	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
76869004172	homotrimer interface [polypeptide binding]; other site
76869004173	Walker A motif; other site
76869004174	GTP binding site [chemical binding]; other site
76869004175	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
76869004176	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
76869004177	putative dimer interface [polypeptide binding]; other site
76869004178	active site pocket [active]
76869004179	putative cataytic base [active]
76869004180	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
76869004181	catalytic core [active]
76869004182	cobalamin synthase; Reviewed; Region: cobS; PRK00235
76869004183	Transcriptional regulators [Transcription]; Region: MarR; COG1846
76869004184	MarR family; Region: MarR_2; pfam12802
76869004185	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
76869004186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004187	putative substrate translocation pore; other site
76869004188	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
76869004189	catalytic residues [active]
76869004190	dimer interface [polypeptide binding]; other site
76869004191	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
76869004192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869004193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004194	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869004195	putative effector binding pocket; other site
76869004196	dimerization interface [polypeptide binding]; other site
76869004197	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
76869004198	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
76869004199	RmuC family; Region: RmuC; pfam02646
76869004200	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
76869004201	Na binding site [ion binding]; other site
76869004202	PAS domain; Region: PAS; smart00091
76869004203	PAS fold; Region: PAS_7; pfam12860
76869004204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869004205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869004206	dimer interface [polypeptide binding]; other site
76869004207	phosphorylation site [posttranslational modification]
76869004208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869004209	ATP binding site [chemical binding]; other site
76869004210	Mg2+ binding site [ion binding]; other site
76869004211	G-X-G motif; other site
76869004212	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869004213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869004214	active site
76869004215	phosphorylation site [posttranslational modification]
76869004216	intermolecular recognition site; other site
76869004217	dimerization interface [polypeptide binding]; other site
76869004218	putative transporter; Provisional; Region: PRK10054
76869004219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004220	putative substrate translocation pore; other site
76869004221	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
76869004222	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869004223	DNA-binding site [nucleotide binding]; DNA binding site
76869004224	UTRA domain; Region: UTRA; pfam07702
76869004225	benzoate transport; Region: 2A0115; TIGR00895
76869004226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004227	putative substrate translocation pore; other site
76869004228	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
76869004229	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
76869004230	active site
76869004231	H+ Antiporter protein; Region: 2A0121; TIGR00900
76869004232	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
76869004233	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
76869004234	putative acyl-acceptor binding pocket; other site
76869004235	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
76869004236	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
76869004237	Sodium Bile acid symporter family; Region: SBF; cl17470
76869004238	recombination associated protein; Reviewed; Region: rdgC; PRK00321
76869004239	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
76869004240	methionine aminopeptidase; Provisional; Region: PRK08671
76869004241	active site
76869004242	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
76869004243	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
76869004244	[4Fe-4S] binding site [ion binding]; other site
76869004245	molybdopterin cofactor binding site; other site
76869004246	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
76869004247	molybdopterin cofactor binding site; other site
76869004248	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
76869004249	Flavodoxin; Region: Flavodoxin_1; pfam00258
76869004250	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
76869004251	FAD binding pocket [chemical binding]; other site
76869004252	FAD binding motif [chemical binding]; other site
76869004253	catalytic residues [active]
76869004254	NAD binding pocket [chemical binding]; other site
76869004255	phosphate binding motif [ion binding]; other site
76869004256	beta-alpha-beta structure motif; other site
76869004257	nitrite reductase subunit NirD; Provisional; Region: PRK14989
76869004258	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869004259	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
76869004260	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
76869004261	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
76869004262	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004263	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869004264	dimerization interface [polypeptide binding]; other site
76869004265	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
76869004266	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
76869004267	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869004268	Uncharacterized conserved protein [Function unknown]; Region: COG3339
76869004269	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869004270	salt bridge; other site
76869004271	non-specific DNA binding site [nucleotide binding]; other site
76869004272	sequence-specific DNA binding site [nucleotide binding]; other site
76869004273	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869004274	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
76869004275	carboxy-terminal protease; Provisional; Region: PRK11186
76869004276	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
76869004277	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
76869004278	protein binding site [polypeptide binding]; other site
76869004279	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
76869004280	Catalytic dyad [active]
76869004281	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
76869004282	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
76869004283	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
76869004284	NAD(P) binding site [chemical binding]; other site
76869004285	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
76869004286	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
76869004287	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
76869004288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869004289	Walker A/P-loop; other site
76869004290	ATP binding site [chemical binding]; other site
76869004291	Q-loop/lid; other site
76869004292	ABC transporter signature motif; other site
76869004293	Walker B; other site
76869004294	D-loop; other site
76869004295	H-loop/switch region; other site
76869004296	TOBE domain; Region: TOBE_2; pfam08402
76869004297	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869004298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869004299	dimer interface [polypeptide binding]; other site
76869004300	conserved gate region; other site
76869004301	ABC-ATPase subunit interface; other site
76869004302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869004303	dimer interface [polypeptide binding]; other site
76869004304	conserved gate region; other site
76869004305	putative PBP binding loops; other site
76869004306	ABC-ATPase subunit interface; other site
76869004307	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
76869004308	Sulfatase; Region: Sulfatase; cl17466
76869004309	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869004310	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
76869004311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869004312	transcriptional regulator protein; Region: phnR; TIGR03337
76869004313	DNA-binding site [nucleotide binding]; DNA binding site
76869004314	UTRA domain; Region: UTRA; pfam07702
76869004315	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
76869004316	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869004317	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
76869004318	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
76869004319	active site
76869004320	metal binding site [ion binding]; metal-binding site
76869004321	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
76869004322	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
76869004323	active site
76869004324	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
76869004325	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
76869004326	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
76869004327	Switch I; other site
76869004328	Switch II; other site
76869004329	septum formation inhibitor; Reviewed; Region: minC; PRK00339
76869004330	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
76869004331	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
76869004332	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
76869004333	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
76869004334	putative acyl-acceptor binding pocket; other site
76869004335	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
76869004336	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
76869004337	active site
76869004338	nucleophile elbow; other site
76869004339	VacJ like lipoprotein; Region: VacJ; cl01073
76869004340	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
76869004341	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
76869004342	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
76869004343	Predicted membrane protein [Function unknown]; Region: COG3162
76869004344	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
76869004345	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
76869004346	Na binding site [ion binding]; other site
76869004347	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
76869004348	short chain dehydrogenase; Provisional; Region: PRK05650
76869004349	classical (c) SDRs; Region: SDR_c; cd05233
76869004350	NAD(P) binding site [chemical binding]; other site
76869004351	active site
76869004352	Global regulator protein family; Region: CsrA; pfam02599
76869004353	hypothetical protein; Provisional; Region: PRK00304
76869004354	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
76869004355	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
76869004356	putative oligomer interface [polypeptide binding]; other site
76869004357	putative active site [active]
76869004358	metal binding site [ion binding]; metal-binding site
76869004359	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
76869004360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869004361	Coenzyme A binding pocket [chemical binding]; other site
76869004362	ATP-grasp domain; Region: ATP-grasp_4; cl17255
76869004363	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
76869004364	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
76869004365	active site
76869004366	dimer interface [polypeptide binding]; other site
76869004367	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
76869004368	Ligand Binding Site [chemical binding]; other site
76869004369	Molecular Tunnel; other site
76869004370	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
76869004371	Uncharacterized conserved protein [Function unknown]; Region: COG4121
76869004372	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
76869004373	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
76869004374	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
76869004375	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869004376	EamA-like transporter family; Region: EamA; pfam00892
76869004377	fumarate hydratase; Provisional; Region: PRK12425
76869004378	Class II fumarases; Region: Fumarase_classII; cd01362
76869004379	active site
76869004380	tetramer interface [polypeptide binding]; other site
76869004381	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
76869004382	BolA-like protein; Region: BolA; pfam01722
76869004383	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
76869004384	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
76869004385	active site residue [active]
76869004386	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
76869004387	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
76869004388	catalytic residues [active]
76869004389	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869004390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869004391	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
76869004392	Walker A/P-loop; other site
76869004393	ATP binding site [chemical binding]; other site
76869004394	Q-loop/lid; other site
76869004395	ABC transporter signature motif; other site
76869004396	Walker B; other site
76869004397	D-loop; other site
76869004398	H-loop/switch region; other site
76869004399	PAS domain S-box; Region: sensory_box; TIGR00229
76869004400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869004401	putative active site [active]
76869004402	heme pocket [chemical binding]; other site
76869004403	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869004404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869004405	metal binding site [ion binding]; metal-binding site
76869004406	active site
76869004407	I-site; other site
76869004408	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869004409	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
76869004410	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
76869004411	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869004412	NAD(P) binding site [chemical binding]; other site
76869004413	active site
76869004414	phosphoglycolate phosphatase; Provisional; Region: PRK13222
76869004415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869004416	motif II; other site
76869004417	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
76869004418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869004419	S-adenosylmethionine binding site [chemical binding]; other site
76869004420	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
76869004421	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
76869004422	DNA gyrase subunit A; Validated; Region: PRK05560
76869004423	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
76869004424	CAP-like domain; other site
76869004425	active site
76869004426	primary dimer interface [polypeptide binding]; other site
76869004427	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
76869004428	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
76869004429	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
76869004430	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
76869004431	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
76869004432	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
76869004433	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
76869004434	homodimer interface [polypeptide binding]; other site
76869004435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004436	substrate-cofactor binding pocket; other site
76869004437	catalytic residue [active]
76869004438	Chorismate mutase type II; Region: CM_2; cl00693
76869004439	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
76869004440	Prephenate dehydratase; Region: PDT; pfam00800
76869004441	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
76869004442	putative L-Phe binding site [chemical binding]; other site
76869004443	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
76869004444	prephenate dehydrogenase; Validated; Region: PRK08507
76869004445	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
76869004446	hinge; other site
76869004447	active site
76869004448	cytidylate kinase; Provisional; Region: cmk; PRK00023
76869004449	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
76869004450	CMP-binding site; other site
76869004451	The sites determining sugar specificity; other site
76869004452	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
76869004453	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
76869004454	RNA binding site [nucleotide binding]; other site
76869004455	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
76869004456	RNA binding site [nucleotide binding]; other site
76869004457	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
76869004458	RNA binding site [nucleotide binding]; other site
76869004459	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
76869004460	RNA binding site [nucleotide binding]; other site
76869004461	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
76869004462	RNA binding site [nucleotide binding]; other site
76869004463	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
76869004464	RNA binding site [nucleotide binding]; other site
76869004465	Transposase IS200 like; Region: Y1_Tnp; pfam01797
76869004466	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
76869004467	IHF dimer interface [polypeptide binding]; other site
76869004468	IHF - DNA interface [nucleotide binding]; other site
76869004469	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
76869004470	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
76869004471	Beta-Casp domain; Region: Beta-Casp; smart01027
76869004472	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
76869004473	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
76869004474	Chain length determinant protein; Region: Wzz; cl15801
76869004475	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
76869004476	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
76869004477	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869004478	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
76869004479	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
76869004480	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
76869004481	NAD(P) binding site [chemical binding]; other site
76869004482	homodimer interface [polypeptide binding]; other site
76869004483	substrate binding site [chemical binding]; other site
76869004484	active site
76869004485	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
76869004486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869004487	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
76869004488	NAD(P) binding site [chemical binding]; other site
76869004489	active site
76869004490	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
76869004491	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
76869004492	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
76869004493	active site
76869004494	homodimer interface [polypeptide binding]; other site
76869004495	putative glycosyl transferase; Provisional; Region: PRK10307
76869004496	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
76869004497	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
76869004498	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
76869004499	putative NAD(P) binding site [chemical binding]; other site
76869004500	active site
76869004501	putative substrate binding site [chemical binding]; other site
76869004502	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
76869004503	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
76869004504	Mg++ binding site [ion binding]; other site
76869004505	putative catalytic motif [active]
76869004506	putative substrate binding site [chemical binding]; other site
76869004507	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
76869004508	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
76869004509	NAD(P) binding site [chemical binding]; other site
76869004510	homodimer interface [polypeptide binding]; other site
76869004511	substrate binding site [chemical binding]; other site
76869004512	active site
76869004513	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
76869004514	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
76869004515	NAD binding site [chemical binding]; other site
76869004516	substrate binding site [chemical binding]; other site
76869004517	homodimer interface [polypeptide binding]; other site
76869004518	active site
76869004519	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
76869004520	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
76869004521	NADP binding site [chemical binding]; other site
76869004522	active site
76869004523	putative substrate binding site [chemical binding]; other site
76869004524	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
76869004525	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
76869004526	substrate binding site; other site
76869004527	tetramer interface; other site
76869004528	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869004529	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
76869004530	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
76869004531	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869004532	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
76869004533	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
76869004534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869004535	S-adenosylmethionine binding site [chemical binding]; other site
76869004536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
76869004537	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
76869004538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869004539	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
76869004540	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
76869004541	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
76869004542	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
76869004543	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
76869004544	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
76869004545	active site
76869004546	homodimer interface [polypeptide binding]; other site
76869004547	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
76869004548	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
76869004549	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
76869004550	active site
76869004551	dimer interface [polypeptide binding]; other site
76869004552	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
76869004553	Prostaglandin dehydrogenases; Region: PGDH; cd05288
76869004554	NAD(P) binding site [chemical binding]; other site
76869004555	substrate binding site [chemical binding]; other site
76869004556	dimer interface [polypeptide binding]; other site
76869004557	short chain dehydrogenase; Provisional; Region: PRK06172
76869004558	classical (c) SDRs; Region: SDR_c; cd05233
76869004559	NAD(P) binding site [chemical binding]; other site
76869004560	active site
76869004561	HAMP domain; Region: HAMP; pfam00672
76869004562	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869004563	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869004564	dimer interface [polypeptide binding]; other site
76869004565	putative CheW interface [polypeptide binding]; other site
76869004566	benzoate transporter; Region: benE; TIGR00843
76869004567	Benzoate membrane transport protein; Region: BenE; pfam03594
76869004568	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869004569	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
76869004570	putative C-terminal domain interface [polypeptide binding]; other site
76869004571	putative GSH binding site (G-site) [chemical binding]; other site
76869004572	putative dimer interface [polypeptide binding]; other site
76869004573	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
76869004574	N-terminal domain interface [polypeptide binding]; other site
76869004575	dimer interface [polypeptide binding]; other site
76869004576	substrate binding pocket (H-site) [chemical binding]; other site
76869004577	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
76869004578	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
76869004579	GTP cyclohydrolase I; Provisional; Region: PLN03044
76869004580	active site
76869004581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
76869004582	Smr domain; Region: Smr; pfam01713
76869004583	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
76869004584	Isochorismatase family; Region: Isochorismatase; pfam00857
76869004585	catalytic triad [active]
76869004586	conserved cis-peptide bond; other site
76869004587	HemK family putative methylases; Region: hemK_fam; TIGR00536
76869004588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869004589	S-adenosylmethionine binding site [chemical binding]; other site
76869004590	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869004591	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
76869004592	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
76869004593	Tetramer interface [polypeptide binding]; other site
76869004594	active site
76869004595	FMN-binding site [chemical binding]; other site
76869004596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004597	putative substrate translocation pore; other site
76869004598	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
76869004599	Cupin domain; Region: Cupin_2; cl17218
76869004600	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
76869004601	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
76869004602	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
76869004603	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
76869004604	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
76869004605	ZIP Zinc transporter; Region: Zip; pfam02535
76869004606	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
76869004607	Sulfatase; Region: Sulfatase; pfam00884
76869004608	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
76869004609	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869004610	Cytochrome c; Region: Cytochrom_C; pfam00034
76869004611	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
76869004612	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
76869004613	catalytic triad [active]
76869004614	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
76869004615	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
76869004616	oligomer interface [polypeptide binding]; other site
76869004617	metal binding site [ion binding]; metal-binding site
76869004618	metal binding site [ion binding]; metal-binding site
76869004619	putative Cl binding site [ion binding]; other site
76869004620	basic sphincter; other site
76869004621	hydrophobic gate; other site
76869004622	periplasmic entrance; other site
76869004623	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
76869004624	putative acyl-acceptor binding pocket; other site
76869004625	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
76869004626	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869004627	substrate binding site [chemical binding]; other site
76869004628	oxyanion hole (OAH) forming residues; other site
76869004629	trimer interface [polypeptide binding]; other site
76869004630	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869004631	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869004632	N-terminal plug; other site
76869004633	ligand-binding site [chemical binding]; other site
76869004634	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869004635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004636	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869004637	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004638	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
76869004639	putative dimerization interface [polypeptide binding]; other site
76869004640	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
76869004641	classical (c) SDRs; Region: SDR_c; cd05233
76869004642	NAD(P) binding site [chemical binding]; other site
76869004643	active site
76869004644	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869004645	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004646	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869004647	putative effector binding pocket; other site
76869004648	dimerization interface [polypeptide binding]; other site
76869004649	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
76869004650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
76869004651	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
76869004652	elongation factor P; Validated; Region: PRK00529
76869004653	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
76869004654	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
76869004655	RNA binding site [nucleotide binding]; other site
76869004656	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
76869004657	RNA binding site [nucleotide binding]; other site
76869004658	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
76869004659	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869004660	MarR family; Region: MarR; pfam01047
76869004661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869004662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004663	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869004664	putative effector binding pocket; other site
76869004665	dimerization interface [polypeptide binding]; other site
76869004666	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869004667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869004668	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004669	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869004670	dimerization interface [polypeptide binding]; other site
76869004671	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
76869004672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
76869004673	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
76869004674	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
76869004675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869004676	helicase 45; Provisional; Region: PTZ00424
76869004677	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
76869004678	ATP binding site [chemical binding]; other site
76869004679	Mg++ binding site [ion binding]; other site
76869004680	motif III; other site
76869004681	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869004682	nucleotide binding region [chemical binding]; other site
76869004683	ATP-binding site [chemical binding]; other site
76869004684	DbpA RNA binding domain; Region: DbpA; pfam03880
76869004685	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
76869004686	putative active site [active]
76869004687	metal binding site [ion binding]; metal-binding site
76869004688	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
76869004689	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
76869004690	heat shock protein HtpX; Provisional; Region: PRK05457
76869004691	aminotransferase AlaT; Validated; Region: PRK09265
76869004692	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869004693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004694	homodimer interface [polypeptide binding]; other site
76869004695	catalytic residue [active]
76869004696	methionine sulfoxide reductase B; Provisional; Region: PRK00222
76869004697	SelR domain; Region: SelR; pfam01641
76869004698	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
76869004699	catalytic residues [active]
76869004700	dimer interface [polypeptide binding]; other site
76869004701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869004702	dimer interface [polypeptide binding]; other site
76869004703	phosphorylation site [posttranslational modification]
76869004704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869004705	ATP binding site [chemical binding]; other site
76869004706	Mg2+ binding site [ion binding]; other site
76869004707	G-X-G motif; other site
76869004708	Response regulator receiver domain; Region: Response_reg; pfam00072
76869004709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869004710	active site
76869004711	phosphorylation site [posttranslational modification]
76869004712	intermolecular recognition site; other site
76869004713	dimerization interface [polypeptide binding]; other site
76869004714	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
76869004715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869004716	Walker A motif; other site
76869004717	ATP binding site [chemical binding]; other site
76869004718	Walker B motif; other site
76869004719	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
76869004720	GAF domain; Region: GAF_2; pfam13185
76869004721	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
76869004722	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
76869004723	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
76869004724	PapC N-terminal domain; Region: PapC_N; pfam13954
76869004725	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
76869004726	PapC C-terminal domain; Region: PapC_C; pfam13953
76869004727	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869004728	RHS Repeat; Region: RHS_repeat; cl11982
76869004729	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
76869004730	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
76869004731	Autotransporter beta-domain; Region: Autotransporter; pfam03797
76869004732	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
76869004733	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
76869004734	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
76869004735	Fimbrial protein; Region: Fimbrial; cl01416
76869004736	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
76869004737	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
76869004738	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
76869004739	active site
76869004740	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
76869004741	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869004742	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
76869004743	putative C-terminal domain interface [polypeptide binding]; other site
76869004744	putative GSH binding site (G-site) [chemical binding]; other site
76869004745	putative dimer interface [polypeptide binding]; other site
76869004746	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
76869004747	putative N-terminal domain interface [polypeptide binding]; other site
76869004748	putative dimer interface [polypeptide binding]; other site
76869004749	putative substrate binding pocket (H-site) [chemical binding]; other site
76869004750	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
76869004751	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869004752	Walker A/P-loop; other site
76869004753	ATP binding site [chemical binding]; other site
76869004754	Q-loop/lid; other site
76869004755	ABC transporter signature motif; other site
76869004756	Walker B; other site
76869004757	D-loop; other site
76869004758	H-loop/switch region; other site
76869004759	inner membrane transport permease; Provisional; Region: PRK15066
76869004760	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
76869004761	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
76869004762	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
76869004763	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
76869004764	Competence protein; Region: Competence; pfam03772
76869004765	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
76869004766	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
76869004767	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
76869004768	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
76869004769	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
76869004770	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
76869004771	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
76869004772	Uncharacterized conserved protein [Function unknown]; Region: COG2835
76869004773	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
76869004774	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
76869004775	Ligand binding site; other site
76869004776	oligomer interface; other site
76869004777	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
76869004778	Low molecular weight phosphatase family; Region: LMWPc; cd00115
76869004779	active site
76869004780	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
76869004781	FAD binding domain; Region: FAD_binding_4; pfam01565
76869004782	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
76869004783	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
76869004784	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
76869004785	homodimer interface [polypeptide binding]; other site
76869004786	oligonucleotide binding site [chemical binding]; other site
76869004787	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
76869004788	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
76869004789	RNA binding surface [nucleotide binding]; other site
76869004790	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
76869004791	active site
76869004792	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
76869004793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869004794	motif II; other site
76869004795	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
76869004796	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
76869004797	tandem repeat interface [polypeptide binding]; other site
76869004798	oligomer interface [polypeptide binding]; other site
76869004799	active site residues [active]
76869004800	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
76869004801	active site
76869004802	dimer interface [polypeptide binding]; other site
76869004803	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
76869004804	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
76869004805	putative phosphate acyltransferase; Provisional; Region: PRK05331
76869004806	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
76869004807	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
76869004808	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
76869004809	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
76869004810	NAD(P) binding site [chemical binding]; other site
76869004811	homotetramer interface [polypeptide binding]; other site
76869004812	homodimer interface [polypeptide binding]; other site
76869004813	active site
76869004814	acyl carrier protein; Provisional; Region: acpP; PRK00982
76869004815	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
76869004816	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
76869004817	dimer interface [polypeptide binding]; other site
76869004818	active site
76869004819	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
76869004820	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
76869004821	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004822	catalytic residue [active]
76869004823	YceG-like family; Region: YceG; pfam02618
76869004824	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
76869004825	dimerization interface [polypeptide binding]; other site
76869004826	thymidylate kinase; Validated; Region: tmk; PRK00698
76869004827	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
76869004828	TMP-binding site; other site
76869004829	ATP-binding site [chemical binding]; other site
76869004830	DNA polymerase III subunit delta'; Validated; Region: PRK05707
76869004831	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869004832	Walker A motif; other site
76869004833	ATP binding site [chemical binding]; other site
76869004834	Walker B motif; other site
76869004835	arginine finger; other site
76869004836	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
76869004837	active site
76869004838	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869004839	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869004840	WHG domain; Region: WHG; pfam13305
76869004841	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
76869004842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869004843	FeS/SAM binding site; other site
76869004844	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
76869004845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
76869004846	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
76869004847	Cupin domain; Region: Cupin_2; pfam07883
76869004848	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
76869004849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869004850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004851	homodimer interface [polypeptide binding]; other site
76869004852	catalytic residue [active]
76869004853	excinuclease ABC subunit B; Provisional; Region: PRK05298
76869004854	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869004855	ATP binding site [chemical binding]; other site
76869004856	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869004857	nucleotide binding region [chemical binding]; other site
76869004858	ATP-binding site [chemical binding]; other site
76869004859	Ultra-violet resistance protein B; Region: UvrB; pfam12344
76869004860	UvrB/uvrC motif; Region: UVR; pfam02151
76869004861	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
76869004862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004863	putative substrate translocation pore; other site
76869004864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869004865	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
76869004866	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869004867	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
76869004868	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869004869	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
76869004870	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
76869004871	active site
76869004872	HIGH motif; other site
76869004873	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
76869004874	active site
76869004875	KMSKS motif; other site
76869004876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869004877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869004878	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869004879	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
76869004880	active site
76869004881	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
76869004882	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
76869004883	FMN binding site [chemical binding]; other site
76869004884	active site
76869004885	catalytic residues [active]
76869004886	substrate binding site [chemical binding]; other site
76869004887	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
76869004888	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
76869004889	putative dimer interface [polypeptide binding]; other site
76869004890	PAS fold; Region: PAS_3; pfam08447
76869004891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869004892	putative active site [active]
76869004893	heme pocket [chemical binding]; other site
76869004894	PAS domain S-box; Region: sensory_box; TIGR00229
76869004895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869004896	putative active site [active]
76869004897	PAS fold; Region: PAS_3; pfam08447
76869004898	PAS domain S-box; Region: sensory_box; TIGR00229
76869004899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869004900	putative active site [active]
76869004901	heme pocket [chemical binding]; other site
76869004902	PAS domain S-box; Region: sensory_box; TIGR00229
76869004903	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869004904	putative active site [active]
76869004905	heme pocket [chemical binding]; other site
76869004906	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869004907	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869004908	metal binding site [ion binding]; metal-binding site
76869004909	active site
76869004910	I-site; other site
76869004911	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869004912	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869004913	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869004914	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869004915	dimerization interface [polypeptide binding]; other site
76869004916	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
76869004917	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
76869004918	substrate binding site [chemical binding]; other site
76869004919	ligand binding site [chemical binding]; other site
76869004920	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
76869004921	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
76869004922	substrate binding site [chemical binding]; other site
76869004923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869004924	S-adenosylmethionine binding site [chemical binding]; other site
76869004925	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
76869004926	tartrate dehydrogenase; Region: TTC; TIGR02089
76869004927	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
76869004928	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
76869004929	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
76869004930	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869004931	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869004932	DNA binding residues [nucleotide binding]
76869004933	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869004934	FecR protein; Region: FecR; pfam04773
76869004935	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
76869004936	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
76869004937	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
76869004938	Protein of unknown function (DUF560); Region: DUF560; pfam04575
76869004939	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
76869004940	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
76869004941	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
76869004942	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
76869004943	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
76869004944	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
76869004945	dimerization interface 3.5A [polypeptide binding]; other site
76869004946	active site
76869004947	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
76869004948	active site
76869004949	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
76869004950	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
76869004951	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
76869004952	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
76869004953	Sporulation related domain; Region: SPOR; pfam05036
76869004954	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
76869004955	Colicin V production protein; Region: Colicin_V; cl00567
76869004956	amidophosphoribosyltransferase; Provisional; Region: PRK09246
76869004957	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
76869004958	active site
76869004959	tetramer interface [polypeptide binding]; other site
76869004960	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869004961	active site
76869004962	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
76869004963	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
76869004964	homodimer interface [polypeptide binding]; other site
76869004965	substrate-cofactor binding pocket; other site
76869004966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869004967	catalytic residue [active]
76869004968	oxidoreductase; Validated; Region: PRK05717
76869004969	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869004970	NAD(P) binding site [chemical binding]; other site
76869004971	active site
76869004972	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
76869004973	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869004974	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869004975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869004976	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
76869004977	active site
76869004978	catalytic triad [active]
76869004979	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
76869004980	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
76869004981	active site
76869004982	FMN binding site [chemical binding]; other site
76869004983	2,4-decadienoyl-CoA binding site; other site
76869004984	catalytic residue [active]
76869004985	4Fe-4S cluster binding site [ion binding]; other site
76869004986	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
76869004987	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
76869004988	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
76869004989	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
76869004990	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
76869004991	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
76869004992	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
76869004993	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
76869004994	active site
76869004995	metal binding site [ion binding]; metal-binding site
76869004996	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
76869004997	Rhomboid family; Region: Rhomboid; pfam01694
76869004998	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
76869004999	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
76869005000	aminopeptidase N; Provisional; Region: pepN; PRK14015
76869005001	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
76869005002	active site
76869005003	Zn binding site [ion binding]; other site
76869005004	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
76869005005	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
76869005006	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
76869005007	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869005008	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
76869005009	putative GSH binding site (G-site) [chemical binding]; other site
76869005010	active site cysteine [active]
76869005011	putative C-terminal domain interface [polypeptide binding]; other site
76869005012	putative dimer interface [polypeptide binding]; other site
76869005013	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
76869005014	putative dimer interface [polypeptide binding]; other site
76869005015	putative N-terminal domain interface [polypeptide binding]; other site
76869005016	putative substrate binding pocket (H-site) [chemical binding]; other site
76869005017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869005018	AAA domain; Region: AAA_23; pfam13476
76869005019	Walker A/P-loop; other site
76869005020	ATP binding site [chemical binding]; other site
76869005021	Q-loop/lid; other site
76869005022	exonuclease subunit SbcC; Provisional; Region: PRK10246
76869005023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869005024	ABC transporter signature motif; other site
76869005025	Walker B; other site
76869005026	D-loop; other site
76869005027	H-loop/switch region; other site
76869005028	exonuclease subunit SbcD; Provisional; Region: PRK10966
76869005029	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
76869005030	active site
76869005031	metal binding site [ion binding]; metal-binding site
76869005032	DNA binding site [nucleotide binding]
76869005033	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
76869005034	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869005035	Oxygen tolerance; Region: BatD; pfam13584
76869005036	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
76869005037	von Willebrand factor type A domain; Region: VWA_2; pfam13519
76869005038	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869005039	Tetratricopeptide repeat; Region: TPR_16; pfam13432
76869005040	TPR motif; other site
76869005041	binding surface
76869005042	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
76869005043	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
76869005044	metal ion-dependent adhesion site (MIDAS); other site
76869005045	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
76869005046	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
76869005047	Protein of unknown function DUF58; Region: DUF58; pfam01882
76869005048	MoxR-like ATPases [General function prediction only]; Region: COG0714
76869005049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869005050	Walker A motif; other site
76869005051	ATP binding site [chemical binding]; other site
76869005052	Walker B motif; other site
76869005053	arginine finger; other site
76869005054	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
76869005055	benzoate transporter; Region: benE; TIGR00843
76869005056	Benzoate membrane transport protein; Region: BenE; pfam03594
76869005057	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
76869005058	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
76869005059	inhibitor site; inhibition site
76869005060	active site
76869005061	dimer interface [polypeptide binding]; other site
76869005062	catalytic residue [active]
76869005063	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
76869005064	intersubunit interface [polypeptide binding]; other site
76869005065	active site
76869005066	Zn2+ binding site [ion binding]; other site
76869005067	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
76869005068	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
76869005069	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
76869005070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869005071	motif II; other site
76869005072	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
76869005073	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
76869005074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869005075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005076	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
76869005077	putative dimerization interface [polypeptide binding]; other site
76869005078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
76869005079	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
76869005080	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
76869005081	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
76869005082	Citrate transporter; Region: CitMHS; pfam03600
76869005083	outer membrane porin, OprD family; Region: OprD; pfam03573
76869005084	CsbD-like; Region: CsbD; pfam05532
76869005085	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
76869005086	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
76869005087	DNA binding residues [nucleotide binding]
76869005088	dimer interface [polypeptide binding]; other site
76869005089	[2Fe-2S] cluster binding site [ion binding]; other site
76869005090	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869005091	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869005092	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869005093	multidrug efflux protein; Reviewed; Region: PRK09579
76869005094	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
76869005095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869005096	DNA-binding site [nucleotide binding]; DNA binding site
76869005097	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
76869005098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
76869005099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869005100	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869005101	Coenzyme A binding pocket [chemical binding]; other site
76869005102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869005103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005104	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
76869005105	putative substrate binding pocket [chemical binding]; other site
76869005106	putative dimerization interface [polypeptide binding]; other site
76869005107	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869005108	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869005109	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869005110	N-terminal plug; other site
76869005111	ligand-binding site [chemical binding]; other site
76869005112	fec operon regulator FecR; Reviewed; Region: PRK09774
76869005113	FecR protein; Region: FecR; pfam04773
76869005114	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869005115	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869005116	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869005117	DNA binding residues [nucleotide binding]
76869005118	diaminopimelate decarboxylase; Provisional; Region: PRK11165
76869005119	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
76869005120	active site
76869005121	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869005122	substrate binding site [chemical binding]; other site
76869005123	catalytic residues [active]
76869005124	dimer interface [polypeptide binding]; other site
76869005125	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
76869005126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005127	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869005128	dimerization interface [polypeptide binding]; other site
76869005129	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
76869005130	PEP synthetase regulatory protein; Provisional; Region: PRK05339
76869005131	phosphoenolpyruvate synthase; Validated; Region: PRK06464
76869005132	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
76869005133	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
76869005134	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
76869005135	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869005136	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
76869005137	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
76869005138	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
76869005139	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
76869005140	Cl binding site [ion binding]; other site
76869005141	oligomer interface [polypeptide binding]; other site
76869005142	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
76869005143	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869005144	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869005145	DNA binding residues [nucleotide binding]
76869005146	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
76869005147	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869005148	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869005149	ligand binding site [chemical binding]; other site
76869005150	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
76869005151	active site
76869005152	SAM binding site [chemical binding]; other site
76869005153	homodimer interface [polypeptide binding]; other site
76869005154	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
76869005155	active site
76869005156	Catalytic domain of Protein Kinases; Region: PKc; cd00180
76869005157	active site
76869005158	ATP binding site [chemical binding]; other site
76869005159	substrate binding site [chemical binding]; other site
76869005160	activation loop (A-loop); other site
76869005161	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
76869005162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869005163	putative substrate translocation pore; other site
76869005164	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
76869005165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005166	active site
76869005167	phosphorylation site [posttranslational modification]
76869005168	intermolecular recognition site; other site
76869005169	dimerization interface [polypeptide binding]; other site
76869005170	ANTAR domain; Region: ANTAR; pfam03861
76869005171	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869005172	NMT1-like family; Region: NMT1_2; pfam13379
76869005173	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
76869005174	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
76869005175	quinone interaction residues [chemical binding]; other site
76869005176	active site
76869005177	catalytic residues [active]
76869005178	FMN binding site [chemical binding]; other site
76869005179	substrate binding site [chemical binding]; other site
76869005180	Ribosome modulation factor; Region: RMF; pfam04957
76869005181	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
76869005182	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
76869005183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
76869005184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869005185	S-adenosylmethionine binding site [chemical binding]; other site
76869005186	CHASE domain; Region: CHASE; pfam03924
76869005187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869005188	PAS domain; Region: PAS_9; pfam13426
76869005189	putative active site [active]
76869005190	heme pocket [chemical binding]; other site
76869005191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869005192	heme pocket [chemical binding]; other site
76869005193	putative active site [active]
76869005194	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869005195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869005196	metal binding site [ion binding]; metal-binding site
76869005197	active site
76869005198	I-site; other site
76869005199	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
76869005200	hypothetical protein; Provisional; Region: PRK11702
76869005201	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869005202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869005203	ATP binding site [chemical binding]; other site
76869005204	Mg2+ binding site [ion binding]; other site
76869005205	G-X-G motif; other site
76869005206	Response regulator receiver domain; Region: Response_reg; pfam00072
76869005207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005208	active site
76869005209	phosphorylation site [posttranslational modification]
76869005210	intermolecular recognition site; other site
76869005211	dimerization interface [polypeptide binding]; other site
76869005212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
76869005213	Transposase; Region: HTH_Tnp_1; pfam01527
76869005214	putative transposase OrfB; Reviewed; Region: PHA02517
76869005215	HTH-like domain; Region: HTH_21; pfam13276
76869005216	Integrase core domain; Region: rve; pfam00665
76869005217	Integrase core domain; Region: rve_2; pfam13333
76869005218	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
76869005219	nucleotide binding site [chemical binding]; other site
76869005220	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
76869005221	nucleotide binding site [chemical binding]; other site
76869005222	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
76869005223	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
76869005224	KxxxW cyclic peptide radical SAM maturase; Region: rSAM_pep_cyc; TIGR04080
76869005225	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869005226	FeS/SAM binding site; other site
76869005227	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
76869005228	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869005229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005230	non-specific DNA binding site [nucleotide binding]; other site
76869005231	salt bridge; other site
76869005232	sequence-specific DNA binding site [nucleotide binding]; other site
76869005233	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
76869005234	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869005235	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005236	non-specific DNA binding site [nucleotide binding]; other site
76869005237	salt bridge; other site
76869005238	sequence-specific DNA binding site [nucleotide binding]; other site
76869005239	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
76869005240	Transposase; Region: DEDD_Tnp_IS110; pfam01548
76869005241	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
76869005242	active site
76869005243	NTP binding site [chemical binding]; other site
76869005244	nucleic acid binding site [nucleotide binding]; other site
76869005245	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
76869005246	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
76869005247	putative active site [active]
76869005248	putative NTP binding site [chemical binding]; other site
76869005249	putative nucleic acid binding site [nucleotide binding]; other site
76869005250	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
76869005251	active site
76869005252	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869005253	active site
76869005254	catalytic residues [active]
76869005255	DNA binding site [nucleotide binding]
76869005256	Int/Topo IB signature motif; other site
76869005257	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869005258	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869005259	substrate binding pocket [chemical binding]; other site
76869005260	membrane-bound complex binding site; other site
76869005261	hinge residues; other site
76869005262	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869005263	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869005264	substrate binding pocket [chemical binding]; other site
76869005265	membrane-bound complex binding site; other site
76869005266	hinge residues; other site
76869005267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869005268	PAS domain; Region: PAS_9; pfam13426
76869005269	putative active site [active]
76869005270	heme pocket [chemical binding]; other site
76869005271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869005272	dimer interface [polypeptide binding]; other site
76869005273	phosphorylation site [posttranslational modification]
76869005274	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869005275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005276	active site
76869005277	phosphorylation site [posttranslational modification]
76869005278	intermolecular recognition site; other site
76869005279	dimerization interface [polypeptide binding]; other site
76869005280	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869005281	DNA binding residues [nucleotide binding]
76869005282	dimerization interface [polypeptide binding]; other site
76869005283	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
76869005284	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
76869005285	Zn2+ binding site [ion binding]; other site
76869005286	Mg2+ binding site [ion binding]; other site
76869005287	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
76869005288	Predicted membrane protein [Function unknown]; Region: COG5393
76869005289	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
76869005290	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
76869005291	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
76869005292	Peptidase M15; Region: Peptidase_M15_3; pfam08291
76869005293	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
76869005294	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
76869005295	active site
76869005296	PAS domain; Region: PAS_9; pfam13426
76869005297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869005298	putative active site [active]
76869005299	heme pocket [chemical binding]; other site
76869005300	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869005301	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869005302	dimer interface [polypeptide binding]; other site
76869005303	putative CheW interface [polypeptide binding]; other site
76869005304	aconitate hydratase; Validated; Region: PRK09277
76869005305	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
76869005306	substrate binding site [chemical binding]; other site
76869005307	ligand binding site [chemical binding]; other site
76869005308	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
76869005309	substrate binding site [chemical binding]; other site
76869005310	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
76869005311	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
76869005312	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
76869005313	CPxP  motif; other site
76869005314	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
76869005315	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
76869005316	ligand binding site [chemical binding]; other site
76869005317	NAD binding site [chemical binding]; other site
76869005318	catalytic site [active]
76869005319	homodimer interface [polypeptide binding]; other site
76869005320	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
76869005321	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869005322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869005323	Walker A/P-loop; other site
76869005324	ATP binding site [chemical binding]; other site
76869005325	Q-loop/lid; other site
76869005326	ABC transporter signature motif; other site
76869005327	Walker B; other site
76869005328	D-loop; other site
76869005329	H-loop/switch region; other site
76869005330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869005331	dimerization interface [polypeptide binding]; other site
76869005332	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869005333	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869005334	dimer interface [polypeptide binding]; other site
76869005335	putative CheW interface [polypeptide binding]; other site
76869005336	malate:quinone oxidoreductase; Validated; Region: PRK05257
76869005337	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
76869005338	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
76869005339	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
76869005340	MPT binding site; other site
76869005341	trimer interface [polypeptide binding]; other site
76869005342	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
76869005343	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
76869005344	dimer interface [polypeptide binding]; other site
76869005345	putative functional site; other site
76869005346	putative MPT binding site; other site
76869005347	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
76869005348	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
76869005349	lipid kinase; Reviewed; Region: PRK13054
76869005350	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
76869005351	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869005352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005353	active site
76869005354	phosphorylation site [posttranslational modification]
76869005355	intermolecular recognition site; other site
76869005356	dimerization interface [polypeptide binding]; other site
76869005357	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869005358	DNA binding residues [nucleotide binding]
76869005359	dimerization interface [polypeptide binding]; other site
76869005360	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
76869005361	Histidine kinase; Region: HisKA_3; pfam07730
76869005362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869005363	ATP binding site [chemical binding]; other site
76869005364	Mg2+ binding site [ion binding]; other site
76869005365	G-X-G motif; other site
76869005366	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
76869005367	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869005368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005369	active site
76869005370	phosphorylation site [posttranslational modification]
76869005371	intermolecular recognition site; other site
76869005372	dimerization interface [polypeptide binding]; other site
76869005373	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
76869005374	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
76869005375	MOSC domain; Region: MOSC; pfam03473
76869005376	lytic murein transglycosylase; Provisional; Region: PRK11619
76869005377	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869005378	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869005379	catalytic residue [active]
76869005380	ABC transporter ATPase component; Reviewed; Region: PRK11147
76869005381	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869005382	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869005383	ABC transporter; Region: ABC_tran_2; pfam12848
76869005384	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869005385	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869005386	Ligand Binding Site [chemical binding]; other site
76869005387	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
76869005388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869005389	substrate binding site [chemical binding]; other site
76869005390	oxyanion hole (OAH) forming residues; other site
76869005391	trimer interface [polypeptide binding]; other site
76869005392	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
76869005393	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
76869005394	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
76869005395	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869005396	dimer interface [polypeptide binding]; other site
76869005397	active site
76869005398	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
76869005399	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
76869005400	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
76869005401	active site
76869005402	interdomain interaction site; other site
76869005403	putative metal-binding site [ion binding]; other site
76869005404	nucleotide binding site [chemical binding]; other site
76869005405	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
76869005406	domain I; other site
76869005407	DNA binding groove [nucleotide binding]
76869005408	phosphate binding site [ion binding]; other site
76869005409	domain II; other site
76869005410	domain III; other site
76869005411	nucleotide binding site [chemical binding]; other site
76869005412	catalytic site [active]
76869005413	domain IV; other site
76869005414	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
76869005415	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
76869005416	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
76869005417	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
76869005418	Cell division inhibitor SulA; Region: SulA; cl01880
76869005419	LexA repressor; Validated; Region: PRK00215
76869005420	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
76869005421	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869005422	Catalytic site [active]
76869005423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869005424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869005425	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
76869005426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
76869005427	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
76869005428	beta-hexosaminidase; Provisional; Region: PRK05337
76869005429	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
76869005430	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
76869005431	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
76869005432	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869005433	ATP binding site [chemical binding]; other site
76869005434	putative Mg++ binding site [ion binding]; other site
76869005435	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869005436	nucleotide binding region [chemical binding]; other site
76869005437	ATP-binding site [chemical binding]; other site
76869005438	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
76869005439	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
76869005440	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
76869005441	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869005442	ATP binding site [chemical binding]; other site
76869005443	putative Mg++ binding site [ion binding]; other site
76869005444	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869005445	nucleotide binding region [chemical binding]; other site
76869005446	ATP-binding site [chemical binding]; other site
76869005447	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
76869005448	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
76869005449	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
76869005450	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
76869005451	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
76869005452	ApbE family; Region: ApbE; pfam02424
76869005453	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
76869005454	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869005455	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
76869005456	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
76869005457	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
76869005458	active site
76869005459	catalytic site [active]
76869005460	metal binding site [ion binding]; metal-binding site
76869005461	PilZ domain; Region: PilZ; pfam07238
76869005462	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
76869005463	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
76869005464	FtsX-like permease family; Region: FtsX; pfam02687
76869005465	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
76869005466	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
76869005467	Walker A/P-loop; other site
76869005468	ATP binding site [chemical binding]; other site
76869005469	Q-loop/lid; other site
76869005470	ABC transporter signature motif; other site
76869005471	Walker B; other site
76869005472	D-loop; other site
76869005473	H-loop/switch region; other site
76869005474	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
76869005475	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
76869005476	FtsX-like permease family; Region: FtsX; pfam02687
76869005477	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
76869005478	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869005479	dimerization interface [polypeptide binding]; other site
76869005480	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869005481	dimer interface [polypeptide binding]; other site
76869005482	phosphorylation site [posttranslational modification]
76869005483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869005484	ATP binding site [chemical binding]; other site
76869005485	Mg2+ binding site [ion binding]; other site
76869005486	G-X-G motif; other site
76869005487	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
76869005488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005489	active site
76869005490	phosphorylation site [posttranslational modification]
76869005491	intermolecular recognition site; other site
76869005492	dimerization interface [polypeptide binding]; other site
76869005493	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869005494	DNA binding site [nucleotide binding]
76869005495	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
76869005496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
76869005497	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
76869005498	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
76869005499	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
76869005500	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
76869005501	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
76869005502	PilZ domain; Region: PilZ; pfam07238
76869005503	Response regulator receiver domain; Region: Response_reg; pfam00072
76869005504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869005505	active site
76869005506	phosphorylation site [posttranslational modification]
76869005507	intermolecular recognition site; other site
76869005508	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
76869005509	dimerization interface [polypeptide binding]; other site
76869005510	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
76869005511	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
76869005512	anti sigma factor interaction site; other site
76869005513	regulatory phosphorylation site [posttranslational modification]; other site
76869005514	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
76869005515	metal binding site [ion binding]; metal-binding site
76869005516	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
76869005517	putative active site [active]
76869005518	putative metal binding site [ion binding]; other site
76869005519	transaldolase-like protein; Provisional; Region: PTZ00411
76869005520	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
76869005521	active site
76869005522	dimer interface [polypeptide binding]; other site
76869005523	catalytic residue [active]
76869005524	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
76869005525	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
76869005526	FMN binding site [chemical binding]; other site
76869005527	active site
76869005528	catalytic residues [active]
76869005529	substrate binding site [chemical binding]; other site
76869005530	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869005531	active site
76869005532	DNA binding site [nucleotide binding]
76869005533	Int/Topo IB signature motif; other site
76869005534	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
76869005535	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
76869005536	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
76869005537	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
76869005538	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
76869005539	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
76869005540	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
76869005541	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
76869005542	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
76869005543	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
76869005544	substrate interaction site [chemical binding]; other site
76869005545	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
76869005546	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
76869005547	active site
76869005548	catalytic site [active]
76869005549	substrate binding site [chemical binding]; other site
76869005550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869005551	AAA domain; Region: AAA_23; pfam13476
76869005552	Walker A/P-loop; other site
76869005553	ATP binding site [chemical binding]; other site
76869005554	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
76869005555	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
76869005556	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
76869005557	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
76869005558	Predicted transcriptional regulator [Transcription]; Region: COG2932
76869005559	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005560	non-specific DNA binding site [nucleotide binding]; other site
76869005561	salt bridge; other site
76869005562	sequence-specific DNA binding site [nucleotide binding]; other site
76869005563	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
76869005564	active site
76869005565	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869005566	Catalytic site [active]
76869005567	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005568	non-specific DNA binding site [nucleotide binding]; other site
76869005569	salt bridge; other site
76869005570	sequence-specific DNA binding site [nucleotide binding]; other site
76869005571	Bacteriophage CII protein; Region: Phage_CII; pfam05269
76869005572	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
76869005573	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
76869005574	Lysis protein S; Region: Lysis_S; pfam04971
76869005575	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
76869005576	catalytic residue [active]
76869005577	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
76869005578	Terminase small subunit; Region: Terminase_2; pfam03592
76869005579	hypothetical protein; Region: PHA00670
76869005580	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
76869005581	putative protease; Region: PHA00666
76869005582	major capsid protein; Region: PHA00665
76869005583	hypothetical protein; Region: PHA00664
76869005584	hypothetical protein; Region: PHA00662
76869005585	hypothetical protein; Region: PHA00661
76869005586	hypothetical protein; Region: PHA01733
76869005587	putative lysin; Region: PHA00658
76869005588	structural protein; Region: PHA01972
76869005589	Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219
76869005590	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
76869005591	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
76869005592	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
76869005593	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
76869005594	Malic enzyme, N-terminal domain; Region: malic; pfam00390
76869005595	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
76869005596	putative NAD(P) binding site [chemical binding]; other site
76869005597	dihydroorotase; Reviewed; Region: PRK09236
76869005598	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
76869005599	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
76869005600	active site
76869005601	allantoate amidohydrolase; Reviewed; Region: PRK09290
76869005602	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
76869005603	active site
76869005604	metal binding site [ion binding]; metal-binding site
76869005605	dimer interface [polypeptide binding]; other site
76869005606	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
76869005607	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
76869005608	heterodimer interface [polypeptide binding]; other site
76869005609	active site
76869005610	FMN binding site [chemical binding]; other site
76869005611	homodimer interface [polypeptide binding]; other site
76869005612	substrate binding site [chemical binding]; other site
76869005613	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
76869005614	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
76869005615	FAD binding pocket [chemical binding]; other site
76869005616	FAD binding motif [chemical binding]; other site
76869005617	phosphate binding motif [ion binding]; other site
76869005618	beta-alpha-beta structure motif; other site
76869005619	NAD binding pocket [chemical binding]; other site
76869005620	Iron coordination center [ion binding]; other site
76869005621	benzoate transport; Region: 2A0115; TIGR00895
76869005622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869005623	putative substrate translocation pore; other site
76869005624	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
76869005625	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869005626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005627	non-specific DNA binding site [nucleotide binding]; other site
76869005628	salt bridge; other site
76869005629	sequence-specific DNA binding site [nucleotide binding]; other site
76869005630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869005631	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869005632	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869005633	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
76869005634	Uncharacterized conserved protein [Function unknown]; Region: COG3791
76869005635	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
76869005636	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
76869005637	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869005638	Na binding site [ion binding]; other site
76869005639	putative substrate binding site [chemical binding]; other site
76869005640	hypothetical protein; Provisional; Region: PRK06132
76869005641	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
76869005642	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
76869005643	Protein of unknown function (DUF533); Region: DUF533; pfam04391
76869005644	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
76869005645	putative metal binding site [ion binding]; other site
76869005646	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
76869005647	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869005648	catalytic residue [active]
76869005649	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869005650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005651	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
76869005652	dimerization interface [polypeptide binding]; other site
76869005653	substrate binding pocket [chemical binding]; other site
76869005654	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
76869005655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005656	non-specific DNA binding site [nucleotide binding]; other site
76869005657	salt bridge; other site
76869005658	sequence-specific DNA binding site [nucleotide binding]; other site
76869005659	Cupin domain; Region: Cupin_2; pfam07883
76869005660	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869005661	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869005662	Peptidase C26; Region: Peptidase_C26; pfam07722
76869005663	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
76869005664	catalytic triad [active]
76869005665	putative aminotransferase; Validated; Region: PRK07480
76869005666	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869005667	inhibitor-cofactor binding pocket; inhibition site
76869005668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869005669	catalytic residue [active]
76869005670	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869005671	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005672	non-specific DNA binding site [nucleotide binding]; other site
76869005673	salt bridge; other site
76869005674	sequence-specific DNA binding site [nucleotide binding]; other site
76869005675	Cupin domain; Region: Cupin_2; pfam07883
76869005676	putative kissing complex interaction region; other site
76869005677	putative RNA binding sites [nucleotide binding]; other site
76869005678	ProQ/FINO family; Region: ProQ; pfam04352
76869005679	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
76869005680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869005681	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869005682	putative substrate translocation pore; other site
76869005683	Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
76869005684	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869005685	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869005686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869005687	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
76869005688	active site
76869005689	substrate binding site [chemical binding]; other site
76869005690	Phosphotransferase enzyme family; Region: APH; pfam01636
76869005691	ATP binding site [chemical binding]; other site
76869005692	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
76869005693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869005694	NAD(P) binding site [chemical binding]; other site
76869005695	active site
76869005696	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869005697	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
76869005698	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869005699	inhibitor-cofactor binding pocket; inhibition site
76869005700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869005701	catalytic residue [active]
76869005702	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
76869005703	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
76869005704	acyl-activating enzyme (AAE) consensus motif; other site
76869005705	AMP binding site [chemical binding]; other site
76869005706	active site
76869005707	CoA binding site [chemical binding]; other site
76869005708	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
76869005709	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
76869005710	active site
76869005711	dimer interface [polypeptide binding]; other site
76869005712	non-prolyl cis peptide bond; other site
76869005713	insertion regions; other site
76869005714	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869005715	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
76869005716	active site
76869005717	non-prolyl cis peptide bond; other site
76869005718	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869005719	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869005720	N-terminal plug; other site
76869005721	ligand-binding site [chemical binding]; other site
76869005722	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
76869005723	Transcriptional regulator [Transcription]; Region: IclR; COG1414
76869005724	Bacterial transcriptional regulator; Region: IclR; pfam01614
76869005725	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
76869005726	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
76869005727	Walker A/P-loop; other site
76869005728	ATP binding site [chemical binding]; other site
76869005729	Q-loop/lid; other site
76869005730	ABC transporter signature motif; other site
76869005731	Walker B; other site
76869005732	D-loop; other site
76869005733	H-loop/switch region; other site
76869005734	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
76869005735	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
76869005736	intersubunit interface [polypeptide binding]; other site
76869005737	FecCD transport family; Region: FecCD; pfam01032
76869005738	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
76869005739	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
76869005740	ABC-ATPase subunit  interface; other site
76869005741	dimer interface [polypeptide binding]; other site
76869005742	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
76869005743	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
76869005744	putative dimer interface [polypeptide binding]; other site
76869005745	[2Fe-2S] cluster binding site [ion binding]; other site
76869005746	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
76869005747	putative dimer interface [polypeptide binding]; other site
76869005748	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
76869005749	SLBB domain; Region: SLBB; pfam10531
76869005750	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
76869005751	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
76869005752	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869005753	catalytic loop [active]
76869005754	iron binding site [ion binding]; other site
76869005755	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
76869005756	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
76869005757	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
76869005758	[4Fe-4S] binding site [ion binding]; other site
76869005759	molybdopterin cofactor binding site; other site
76869005760	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
76869005761	molybdopterin cofactor binding site; other site
76869005762	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
76869005763	universal stress protein UspE; Provisional; Region: PRK11175
76869005764	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869005765	Ligand Binding Site [chemical binding]; other site
76869005766	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869005767	Ligand Binding Site [chemical binding]; other site
76869005768	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
76869005769	active site
76869005770	dinuclear metal binding site [ion binding]; other site
76869005771	dimerization interface [polypeptide binding]; other site
76869005772	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
76869005773	Water Stress and Hypersensitive response; Region: WHy; smart00769
76869005774	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869005775	RNA polymerase sigma factor; Reviewed; Region: PRK12527
76869005776	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869005777	DNA binding residues [nucleotide binding]
76869005778	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869005779	FecR protein; Region: FecR; pfam04773
76869005780	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869005781	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869005782	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869005783	N-terminal plug; other site
76869005784	ligand-binding site [chemical binding]; other site
76869005785	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869005786	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005787	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869005788	dimerization interface [polypeptide binding]; other site
76869005789	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869005790	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869005791	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
76869005792	agmatinase; Region: agmatinase; TIGR01230
76869005793	oligomer interface [polypeptide binding]; other site
76869005794	putative active site [active]
76869005795	Mn binding site [ion binding]; other site
76869005796	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
76869005797	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
76869005798	Predicted ATPase [General function prediction only]; Region: COG1485
76869005799	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
76869005800	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869005801	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
76869005802	Predicted membrane protein [Function unknown]; Region: COG1238
76869005803	Protein of unknown function, DUF; Region: DUF411; cl01142
76869005804	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
76869005805	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
76869005806	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
76869005807	Multicopper oxidase; Region: Cu-oxidase; pfam00394
76869005808	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
76869005809	putative protease; Provisional; Region: PRK15452
76869005810	Peptidase family U32; Region: Peptidase_U32; pfam01136
76869005811	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
76869005812	Domain of unknown function DUF20; Region: UPF0118; pfam01594
76869005813	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869005814	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869005815	DNA-binding site [nucleotide binding]; DNA binding site
76869005816	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869005817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869005818	homodimer interface [polypeptide binding]; other site
76869005819	catalytic residue [active]
76869005820	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
76869005821	oligomerization interface [polypeptide binding]; other site
76869005822	active site
76869005823	metal binding site [ion binding]; metal-binding site
76869005824	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
76869005825	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869005826	motif II; other site
76869005827	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
76869005828	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869005829	catalytic residue [active]
76869005830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005831	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
76869005832	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869005833	dimerization interface [polypeptide binding]; other site
76869005834	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869005835	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869005836	SurA N-terminal domain; Region: SurA_N; pfam09312
76869005837	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869005838	Leucine rich repeat; Region: LRR_8; pfam13855
76869005839	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
76869005840	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
76869005841	Leucine rich repeat; Region: LRR_8; pfam13855
76869005842	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
76869005843	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
76869005844	acyl-activating enzyme (AAE) consensus motif; other site
76869005845	AMP binding site [chemical binding]; other site
76869005846	active site
76869005847	CoA binding site [chemical binding]; other site
76869005848	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
76869005849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869005850	NAD(P) binding site [chemical binding]; other site
76869005851	active site
76869005852	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
76869005853	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869005854	dimer interface [polypeptide binding]; other site
76869005855	active site
76869005856	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869005857	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
76869005858	FAD binding site [chemical binding]; other site
76869005859	homotetramer interface [polypeptide binding]; other site
76869005860	substrate binding pocket [chemical binding]; other site
76869005861	catalytic base [active]
76869005862	enoyl-CoA hydratase; Provisional; Region: PRK05862
76869005863	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869005864	substrate binding site [chemical binding]; other site
76869005865	oxyanion hole (OAH) forming residues; other site
76869005866	trimer interface [polypeptide binding]; other site
76869005867	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
76869005868	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
76869005869	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
76869005870	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
76869005871	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
76869005872	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
76869005873	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
76869005874	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
76869005875	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
76869005876	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
76869005877	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
76869005878	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
76869005879	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869005880	EamA-like transporter family; Region: EamA; pfam00892
76869005881	EamA-like transporter family; Region: EamA; pfam00892
76869005882	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005883	non-specific DNA binding site [nucleotide binding]; other site
76869005884	salt bridge; other site
76869005885	sequence-specific DNA binding site [nucleotide binding]; other site
76869005886	Cupin domain; Region: Cupin_2; pfam07883
76869005887	Isochorismatase family; Region: Isochorismatase; pfam00857
76869005888	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
76869005889	catalytic triad [active]
76869005890	conserved cis-peptide bond; other site
76869005891	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869005892	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
76869005893	conserved cys residue [active]
76869005894	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869005895	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869005896	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
76869005897	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
76869005898	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
76869005899	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
76869005900	active site
76869005901	threonine and homoserine efflux system; Provisional; Region: PRK10532
76869005902	EamA-like transporter family; Region: EamA; cl17759
76869005903	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
76869005904	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
76869005905	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
76869005906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869005907	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869005908	putative substrate translocation pore; other site
76869005909	transcriptional regulator BetI; Validated; Region: PRK00767
76869005910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869005911	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
76869005912	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
76869005913	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869005914	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
76869005915	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
76869005916	putative active site [active]
76869005917	metal binding site [ion binding]; metal-binding site
76869005918	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
76869005919	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
76869005920	NAD(P) binding site [chemical binding]; other site
76869005921	catalytic residues [active]
76869005922	outer membrane receptor FepA; Provisional; Region: PRK13524
76869005923	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869005924	N-terminal plug; other site
76869005925	ligand-binding site [chemical binding]; other site
76869005926	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
76869005927	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
76869005928	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
76869005929	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
76869005930	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
76869005931	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869005932	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869005933	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005934	non-specific DNA binding site [nucleotide binding]; other site
76869005935	salt bridge; other site
76869005936	sequence-specific DNA binding site [nucleotide binding]; other site
76869005937	Cupin domain; Region: Cupin_2; pfam07883
76869005938	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869005939	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869005940	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
76869005941	homotrimer interaction site [polypeptide binding]; other site
76869005942	putative active site [active]
76869005943	Uncharacterized membrane protein [Function unknown]; Region: COG3949
76869005944	Cache domain; Region: Cache_1; pfam02743
76869005945	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869005946	dimerization interface [polypeptide binding]; other site
76869005947	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869005948	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869005949	dimer interface [polypeptide binding]; other site
76869005950	putative CheW interface [polypeptide binding]; other site
76869005951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869005952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869005953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869005954	dimerization interface [polypeptide binding]; other site
76869005955	Predicted membrane protein [Function unknown]; Region: COG4125
76869005956	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
76869005957	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
76869005958	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869005959	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869005960	DNA-binding site [nucleotide binding]; DNA binding site
76869005961	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869005962	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869005963	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869005964	DNA-binding site [nucleotide binding]; DNA binding site
76869005965	FCD domain; Region: FCD; pfam07729
76869005966	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
76869005967	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
76869005968	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869005969	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869005970	non-specific DNA binding site [nucleotide binding]; other site
76869005971	salt bridge; other site
76869005972	sequence-specific DNA binding site [nucleotide binding]; other site
76869005973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869005974	PAS fold; Region: PAS_3; pfam08447
76869005975	putative active site [active]
76869005976	heme pocket [chemical binding]; other site
76869005977	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869005978	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869005979	dimer interface [polypeptide binding]; other site
76869005980	putative CheW interface [polypeptide binding]; other site
76869005981	PAS domain; Region: PAS_9; pfam13426
76869005982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869005983	putative active site [active]
76869005984	heme pocket [chemical binding]; other site
76869005985	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869005986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869005987	metal binding site [ion binding]; metal-binding site
76869005988	active site
76869005989	I-site; other site
76869005990	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869005991	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869005992	AsnC family; Region: AsnC_trans_reg; pfam01037
76869005993	ornithine cyclodeaminase; Validated; Region: PRK07589
76869005994	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
76869005995	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
76869005996	GAF domain; Region: GAF; pfam01590
76869005997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869005998	Walker A motif; other site
76869005999	ATP binding site [chemical binding]; other site
76869006000	Walker B motif; other site
76869006001	arginine finger; other site
76869006002	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869006003	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
76869006004	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
76869006005	Walker A/P-loop; other site
76869006006	ATP binding site [chemical binding]; other site
76869006007	Q-loop/lid; other site
76869006008	ABC transporter signature motif; other site
76869006009	Walker B; other site
76869006010	D-loop; other site
76869006011	H-loop/switch region; other site
76869006012	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
76869006013	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
76869006014	Walker A/P-loop; other site
76869006015	ATP binding site [chemical binding]; other site
76869006016	Q-loop/lid; other site
76869006017	ABC transporter signature motif; other site
76869006018	Walker B; other site
76869006019	D-loop; other site
76869006020	H-loop/switch region; other site
76869006021	TOBE domain; Region: TOBE_2; pfam08402
76869006022	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
76869006023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869006024	dimer interface [polypeptide binding]; other site
76869006025	conserved gate region; other site
76869006026	putative PBP binding loops; other site
76869006027	ABC-ATPase subunit interface; other site
76869006028	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
76869006029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869006030	dimer interface [polypeptide binding]; other site
76869006031	conserved gate region; other site
76869006032	putative PBP binding loops; other site
76869006033	ABC-ATPase subunit interface; other site
76869006034	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
76869006035	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
76869006036	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
76869006037	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
76869006038	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
76869006039	homodimer interface [polypeptide binding]; other site
76869006040	NADP binding site [chemical binding]; other site
76869006041	substrate binding site [chemical binding]; other site
76869006042	trigger factor; Provisional; Region: tig; PRK01490
76869006043	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869006044	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
76869006045	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
76869006046	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
76869006047	oligomer interface [polypeptide binding]; other site
76869006048	active site residues [active]
76869006049	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
76869006050	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
76869006051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869006052	Walker A motif; other site
76869006053	ATP binding site [chemical binding]; other site
76869006054	Walker B motif; other site
76869006055	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
76869006056	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
76869006057	Found in ATP-dependent protease La (LON); Region: LON; smart00464
76869006058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869006059	Walker A motif; other site
76869006060	ATP binding site [chemical binding]; other site
76869006061	Walker B motif; other site
76869006062	arginine finger; other site
76869006063	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
76869006064	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
76869006065	IHF dimer interface [polypeptide binding]; other site
76869006066	IHF - DNA interface [nucleotide binding]; other site
76869006067	periplasmic folding chaperone; Provisional; Region: PRK10788
76869006068	SurA N-terminal domain; Region: SurA_N_3; pfam13624
76869006069	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
76869006070	hypothetical protein; Provisional; Region: PRK10279
76869006071	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
76869006072	active site
76869006073	nucleophile elbow; other site
76869006074	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
76869006075	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
76869006076	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
76869006077	active site
76869006078	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
76869006079	active site 2 [active]
76869006080	active site 1 [active]
76869006081	Terminase small subunit; Region: Terminase_2; cl01513
76869006082	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
76869006083	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869006084	dimerization interface [polypeptide binding]; other site
76869006085	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869006086	dimer interface [polypeptide binding]; other site
76869006087	putative CheW interface [polypeptide binding]; other site
76869006088	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
76869006089	active site
76869006090	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869006091	substrate binding pocket [chemical binding]; other site
76869006092	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869006093	membrane-bound complex binding site; other site
76869006094	hinge residues; other site
76869006095	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869006096	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869006097	catalytic residue [active]
76869006098	Predicted membrane protein [Function unknown]; Region: COG2259
76869006099	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
76869006100	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
76869006101	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
76869006102	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
76869006103	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
76869006104	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
76869006105	Walker A/P-loop; other site
76869006106	ATP binding site [chemical binding]; other site
76869006107	Q-loop/lid; other site
76869006108	ABC transporter signature motif; other site
76869006109	Walker B; other site
76869006110	D-loop; other site
76869006111	H-loop/switch region; other site
76869006112	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
76869006113	active site
76869006114	catalytic triad [active]
76869006115	oxyanion hole [active]
76869006116	switch loop; other site
76869006117	L,D-transpeptidase; Provisional; Region: PRK10260
76869006118	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
76869006119	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869006120	Coenzyme A binding pocket [chemical binding]; other site
76869006121	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
76869006122	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
76869006123	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
76869006124	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
76869006125	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
76869006126	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869006127	Ligand Binding Site [chemical binding]; other site
76869006128	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
76869006129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006130	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
76869006131	substrate binding site [chemical binding]; other site
76869006132	dimerization interface [polypeptide binding]; other site
76869006133	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
76869006134	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
76869006135	Active Sites [active]
76869006136	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
76869006137	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
76869006138	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
76869006139	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
76869006140	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
76869006141	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
76869006142	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
76869006143	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869006144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869006145	DNA-binding site [nucleotide binding]; DNA binding site
76869006146	FCD domain; Region: FCD; pfam07729
76869006147	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
76869006148	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
76869006149	tetramer interface [polypeptide binding]; other site
76869006150	active site
76869006151	Mg2+/Mn2+ binding site [ion binding]; other site
76869006152	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
76869006153	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
76869006154	dimer interface [polypeptide binding]; other site
76869006155	active site
76869006156	citrylCoA binding site [chemical binding]; other site
76869006157	oxalacetate/citrate binding site [chemical binding]; other site
76869006158	coenzyme A binding site [chemical binding]; other site
76869006159	catalytic triad [active]
76869006160	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
76869006161	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
76869006162	substrate binding site [chemical binding]; other site
76869006163	ligand binding site [chemical binding]; other site
76869006164	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
76869006165	substrate binding site [chemical binding]; other site
76869006166	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
76869006167	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
76869006168	2-methylcitrate dehydratase; Region: prpD; TIGR02330
76869006169	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
76869006170	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
76869006171	substrate binding site [chemical binding]; other site
76869006172	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
76869006173	substrate binding site [chemical binding]; other site
76869006174	ligand binding site [chemical binding]; other site
76869006175	Predicted Fe-S protein [General function prediction only]; Region: COG3313
76869006176	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
76869006177	active site
76869006178	Predicted membrane protein [Function unknown]; Region: COG3212
76869006179	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
76869006180	Predicted membrane protein [Function unknown]; Region: COG3212
76869006181	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869006182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006183	active site
76869006184	phosphorylation site [posttranslational modification]
76869006185	intermolecular recognition site; other site
76869006186	dimerization interface [polypeptide binding]; other site
76869006187	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869006188	DNA binding site [nucleotide binding]
76869006189	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869006190	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869006191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006192	ATP binding site [chemical binding]; other site
76869006193	Mg2+ binding site [ion binding]; other site
76869006194	G-X-G motif; other site
76869006195	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
76869006196	HPP family; Region: HPP; pfam04982
76869006197	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
76869006198	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
76869006199	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869006200	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006201	LysR substrate binding domain; Region: LysR_substrate; pfam03466
76869006202	dimerization interface [polypeptide binding]; other site
76869006203	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
76869006204	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
76869006205	acyl-activating enzyme (AAE) consensus motif; other site
76869006206	putative AMP binding site [chemical binding]; other site
76869006207	putative active site [active]
76869006208	putative CoA binding site [chemical binding]; other site
76869006209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
76869006210	Predicted ATPase [General function prediction only]; Region: COG1485
76869006211	Walker A motif; other site
76869006212	ATP binding site [chemical binding]; other site
76869006213	Walker B motif; other site
76869006214	arginine finger; other site
76869006215	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869006216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006217	active site
76869006218	phosphorylation site [posttranslational modification]
76869006219	intermolecular recognition site; other site
76869006220	dimerization interface [polypeptide binding]; other site
76869006221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
76869006222	PAS fold; Region: PAS_3; pfam08447
76869006223	putative active site [active]
76869006224	heme pocket [chemical binding]; other site
76869006225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869006226	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
76869006227	putative active site [active]
76869006228	heme pocket [chemical binding]; other site
76869006229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869006230	dimer interface [polypeptide binding]; other site
76869006231	phosphorylation site [posttranslational modification]
76869006232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006233	ATP binding site [chemical binding]; other site
76869006234	Mg2+ binding site [ion binding]; other site
76869006235	G-X-G motif; other site
76869006236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006237	intermolecular recognition site; other site
76869006238	active site
76869006239	dimerization interface [polypeptide binding]; other site
76869006240	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869006241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006242	active site
76869006243	phosphorylation site [posttranslational modification]
76869006244	intermolecular recognition site; other site
76869006245	dimerization interface [polypeptide binding]; other site
76869006246	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
76869006247	GAF domain; Region: GAF; pfam01590
76869006248	Phytochrome region; Region: PHY; pfam00360
76869006249	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869006250	dimer interface [polypeptide binding]; other site
76869006251	phosphorylation site [posttranslational modification]
76869006252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006253	ATP binding site [chemical binding]; other site
76869006254	Mg2+ binding site [ion binding]; other site
76869006255	G-X-G motif; other site
76869006256	Spore Coat Protein U domain; Region: SCPU; pfam05229
76869006257	Spore Coat Protein U domain; Region: SCPU; pfam05229
76869006258	Spore Coat Protein U domain; Region: SCPU; pfam05229
76869006259	Spore Coat Protein U domain; Region: SCPU; pfam05229
76869006260	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
76869006261	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
76869006262	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
76869006263	PapC N-terminal domain; Region: PapC_N; pfam13954
76869006264	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
76869006265	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
76869006266	PapC C-terminal domain; Region: PapC_C; pfam13953
76869006267	Spore Coat Protein U domain; Region: SCPU; pfam05229
76869006268	Spore Coat Protein U domain; Region: SCPU; pfam05229
76869006269	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
76869006270	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
76869006271	active site
76869006272	Zn binding site [ion binding]; other site
76869006273	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869006274	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869006275	membrane-bound complex binding site; other site
76869006276	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869006277	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869006278	substrate binding pocket [chemical binding]; other site
76869006279	membrane-bound complex binding site; other site
76869006280	hinge residues; other site
76869006281	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869006282	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869006283	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006285	putative substrate translocation pore; other site
76869006286	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869006287	VacJ like lipoprotein; Region: VacJ; cl01073
76869006288	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869006289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006290	active site
76869006291	phosphorylation site [posttranslational modification]
76869006292	intermolecular recognition site; other site
76869006293	dimerization interface [polypeptide binding]; other site
76869006294	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869006295	DNA binding site [nucleotide binding]
76869006296	HAMP domain; Region: HAMP; pfam00672
76869006297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869006298	dimer interface [polypeptide binding]; other site
76869006299	phosphorylation site [posttranslational modification]
76869006300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006301	ATP binding site [chemical binding]; other site
76869006302	Mg2+ binding site [ion binding]; other site
76869006303	G-X-G motif; other site
76869006304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
76869006305	SnoaL-like domain; Region: SnoaL_2; pfam12680
76869006306	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869006307	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869006308	active site
76869006309	catalytic tetrad [active]
76869006310	Leucine rich repeat; Region: LRR_8; pfam13855
76869006311	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
76869006312	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
76869006313	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
76869006314	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
76869006315	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
76869006316	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
76869006317	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
76869006318	putative ligand binding site [chemical binding]; other site
76869006319	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
76869006320	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
76869006321	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
76869006322	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
76869006323	substrate binding pocket [chemical binding]; other site
76869006324	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
76869006325	B12 binding site [chemical binding]; other site
76869006326	cobalt ligand [ion binding]; other site
76869006327	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
76869006328	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
76869006329	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
76869006330	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
76869006331	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
76869006332	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
76869006333	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
76869006334	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
76869006335	Cu(I) binding site [ion binding]; other site
76869006336	Protein of unknown function (DUF461); Region: DUF461; pfam04314
76869006337	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869006338	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869006339	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006341	Predicted membrane protein [Function unknown]; Region: COG4392
76869006342	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
76869006343	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869006344	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
76869006345	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869006346	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006347	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869006348	dimerization interface [polypeptide binding]; other site
76869006349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869006350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006351	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
76869006352	putative effector binding pocket; other site
76869006353	putative dimerization interface [polypeptide binding]; other site
76869006354	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869006355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006356	putative substrate translocation pore; other site
76869006357	DNA polymerase II; Reviewed; Region: PRK05762
76869006358	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
76869006359	active site
76869006360	catalytic site [active]
76869006361	substrate binding site [chemical binding]; other site
76869006362	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
76869006363	active site
76869006364	metal-binding site
76869006365	Leucine rich repeat; Region: LRR_8; pfam13855
76869006366	Leucine rich repeat; Region: LRR_8; pfam13855
76869006367	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
76869006368	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
76869006369	EF-hand domain pair; Region: EF_hand_5; pfam13499
76869006370	Ca2+ binding site [ion binding]; other site
76869006371	hypothetical protein; Provisional; Region: PRK05409
76869006372	Predicted membrane protein [Function unknown]; Region: COG2259
76869006373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869006374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
76869006375	dimer interface [polypeptide binding]; other site
76869006376	phosphorylation site [posttranslational modification]
76869006377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006378	ATP binding site [chemical binding]; other site
76869006379	Mg2+ binding site [ion binding]; other site
76869006380	G-X-G motif; other site
76869006381	osmolarity response regulator; Provisional; Region: ompR; PRK09468
76869006382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006383	active site
76869006384	phosphorylation site [posttranslational modification]
76869006385	intermolecular recognition site; other site
76869006386	dimerization interface [polypeptide binding]; other site
76869006387	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869006388	DNA binding site [nucleotide binding]
76869006389	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869006390	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
76869006391	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869006392	catalytic residues [active]
76869006393	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
76869006394	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
76869006395	homodimer interface [polypeptide binding]; other site
76869006396	substrate-cofactor binding pocket; other site
76869006397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869006398	catalytic residue [active]
76869006399	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
76869006400	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
76869006401	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869006402	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006403	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
76869006404	putative effector binding pocket; other site
76869006405	putative dimerization interface [polypeptide binding]; other site
76869006406	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869006407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006408	putative substrate translocation pore; other site
76869006409	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869006410	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
76869006411	putative C-terminal domain interface [polypeptide binding]; other site
76869006412	putative GSH binding site (G-site) [chemical binding]; other site
76869006413	putative dimer interface [polypeptide binding]; other site
76869006414	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
76869006415	putative N-terminal domain interface [polypeptide binding]; other site
76869006416	putative dimer interface [polypeptide binding]; other site
76869006417	putative substrate binding pocket (H-site) [chemical binding]; other site
76869006418	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006419	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
76869006420	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869006421	dimerization interface [polypeptide binding]; other site
76869006422	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
76869006423	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
76869006424	putative NAD(P) binding site [chemical binding]; other site
76869006425	putative active site [active]
76869006426	Putative cyclase; Region: Cyclase; pfam04199
76869006427	WYL domain; Region: WYL; pfam13280
76869006428	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
76869006429	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
76869006430	putative NAD(P) binding site [chemical binding]; other site
76869006431	substrate binding site [chemical binding]; other site
76869006432	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
76869006433	putative hydrophobic ligand binding site [chemical binding]; other site
76869006434	protein interface [polypeptide binding]; other site
76869006435	gate; other site
76869006436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869006437	NAD(P) binding site [chemical binding]; other site
76869006438	active site
76869006439	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
76869006440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006441	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
76869006442	dimerization interface [polypeptide binding]; other site
76869006443	substrate binding pocket [chemical binding]; other site
76869006444	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869006445	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869006446	active site
76869006447	catalytic tetrad [active]
76869006448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869006449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006450	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869006451	dimerization interface [polypeptide binding]; other site
76869006452	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869006453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006454	putative substrate translocation pore; other site
76869006455	allantoate amidohydrolase; Reviewed; Region: PRK12893
76869006456	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
76869006457	active site
76869006458	metal binding site [ion binding]; metal-binding site
76869006459	dimer interface [polypeptide binding]; other site
76869006460	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
76869006461	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
76869006462	active site
76869006463	Zn binding site [ion binding]; other site
76869006464	S-type Pyocin; Region: Pyocin_S; pfam06958
76869006465	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869006466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869006467	DNA-binding site [nucleotide binding]; DNA binding site
76869006468	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869006469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869006470	homodimer interface [polypeptide binding]; other site
76869006471	catalytic residue [active]
76869006472	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
76869006473	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
76869006474	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
76869006475	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
76869006476	shikimate binding site; other site
76869006477	NAD(P) binding site [chemical binding]; other site
76869006478	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
76869006479	Dehydroquinase class II; Region: DHquinase_II; pfam01220
76869006480	trimer interface [polypeptide binding]; other site
76869006481	active site
76869006482	dimer interface [polypeptide binding]; other site
76869006483	Outer membrane efflux protein; Region: OEP; pfam02321
76869006484	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
76869006485	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869006486	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
76869006487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006488	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869006489	putative substrate translocation pore; other site
76869006490	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869006491	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869006492	N-terminal plug; other site
76869006493	ligand-binding site [chemical binding]; other site
76869006494	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
76869006495	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
76869006496	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869006497	P-loop; other site
76869006498	Magnesium ion binding site [ion binding]; other site
76869006499	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869006500	Magnesium ion binding site [ion binding]; other site
76869006501	Cache domain; Region: Cache_1; pfam02743
76869006502	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869006503	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869006504	metal binding site [ion binding]; metal-binding site
76869006505	active site
76869006506	I-site; other site
76869006507	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
76869006508	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
76869006509	Coenzyme A binding pocket [chemical binding]; other site
76869006510	outer membrane porin, OprD family; Region: OprD; pfam03573
76869006511	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
76869006512	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
76869006513	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
76869006514	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
76869006515	Walker A/P-loop; other site
76869006516	ATP binding site [chemical binding]; other site
76869006517	Q-loop/lid; other site
76869006518	ABC transporter signature motif; other site
76869006519	Walker B; other site
76869006520	D-loop; other site
76869006521	H-loop/switch region; other site
76869006522	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
76869006523	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
76869006524	dimer interface [polypeptide binding]; other site
76869006525	putative PBP binding regions; other site
76869006526	ABC-ATPase subunit  interface; other site
76869006527	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
76869006528	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
76869006529	putative ligand binding residues [chemical binding]; other site
76869006530	Predicted membrane protein [Function unknown]; Region: COG3503
76869006531	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869006532	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869006533	N-terminal plug; other site
76869006534	ligand-binding site [chemical binding]; other site
76869006535	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
76869006536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869006537	Coenzyme A binding pocket [chemical binding]; other site
76869006538	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
76869006539	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
76869006540	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
76869006541	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
76869006542	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869006543	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869006544	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869006545	N-terminal plug; other site
76869006546	ligand-binding site [chemical binding]; other site
76869006547	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869006548	FecR protein; Region: FecR; pfam04773
76869006549	RNA polymerase sigma factor; Provisional; Region: PRK12525
76869006550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869006551	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869006552	DNA binding residues [nucleotide binding]
76869006553	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
76869006554	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869006555	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869006556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869006557	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
76869006558	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869006559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006561	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
76869006562	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
76869006563	putative NAD(P) binding site [chemical binding]; other site
76869006564	putative substrate binding site [chemical binding]; other site
76869006565	catalytic Zn binding site [ion binding]; other site
76869006566	structural Zn binding site [ion binding]; other site
76869006567	dimer interface [polypeptide binding]; other site
76869006568	putative arabinose transporter; Provisional; Region: PRK03545
76869006569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006570	putative substrate translocation pore; other site
76869006571	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869006572	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869006573	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869006574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006575	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869006576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006577	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869006578	putative effector binding pocket; other site
76869006579	dimerization interface [polypeptide binding]; other site
76869006580	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
76869006581	FMN binding site [chemical binding]; other site
76869006582	dimer interface [polypeptide binding]; other site
76869006583	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
76869006584	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
76869006585	RES domain; Region: RES; pfam08808
76869006586	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
76869006587	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
76869006588	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869006589	catalytic residue [active]
76869006590	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
76869006591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006592	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
76869006593	substrate binding pocket [chemical binding]; other site
76869006594	dimerization interface [polypeptide binding]; other site
76869006595	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869006596	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
76869006597	FAD binding site [chemical binding]; other site
76869006598	substrate binding site [chemical binding]; other site
76869006599	catalytic base [active]
76869006600	PAAR motif; Region: PAAR_motif; pfam05488
76869006601	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
76869006602	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
76869006603	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869006604	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869006605	ligand binding site [chemical binding]; other site
76869006606	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
76869006607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869006608	Walker A/P-loop; other site
76869006609	ATP binding site [chemical binding]; other site
76869006610	Q-loop/lid; other site
76869006611	ABC transporter signature motif; other site
76869006612	Walker B; other site
76869006613	D-loop; other site
76869006614	H-loop/switch region; other site
76869006615	TOBE domain; Region: TOBE_2; pfam08402
76869006616	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869006617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869006618	dimer interface [polypeptide binding]; other site
76869006619	conserved gate region; other site
76869006620	putative PBP binding loops; other site
76869006621	ABC-ATPase subunit interface; other site
76869006622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869006623	dimer interface [polypeptide binding]; other site
76869006624	conserved gate region; other site
76869006625	putative PBP binding loops; other site
76869006626	ABC-ATPase subunit interface; other site
76869006627	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
76869006628	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
76869006629	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485
76869006630	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
76869006631	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
76869006632	dimerization interface [polypeptide binding]; other site
76869006633	active site
76869006634	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
76869006635	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
76869006636	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
76869006637	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869006638	LysR family transcriptional regulator; Provisional; Region: PRK14997
76869006639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869006640	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869006641	putative effector binding pocket; other site
76869006642	dimerization interface [polypeptide binding]; other site
76869006643	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
76869006644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869006645	S-adenosylmethionine binding site [chemical binding]; other site
76869006646	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
76869006647	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
76869006648	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869006649	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
76869006650	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869006651	NAD(P) binding site [chemical binding]; other site
76869006652	active site
76869006653	SnoaL-like domain; Region: SnoaL_2; pfam12680
76869006654	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
76869006655	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
76869006656	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
76869006657	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
76869006658	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
76869006659	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
76869006660	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
76869006661	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869006662	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194
76869006663	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
76869006664	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
76869006665	homodimer interface [polypeptide binding]; other site
76869006666	NADP binding site [chemical binding]; other site
76869006667	substrate binding site [chemical binding]; other site
76869006668	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
76869006669	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
76869006670	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
76869006671	putative active site [active]
76869006672	putative substrate binding site [chemical binding]; other site
76869006673	putative cosubstrate binding site; other site
76869006674	catalytic site [active]
76869006675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
76869006676	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
76869006677	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
76869006678	catalytic triad [active]
76869006679	conserved cis-peptide bond; other site
76869006680	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
76869006681	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
76869006682	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
76869006683	intersubunit interface [polypeptide binding]; other site
76869006684	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
76869006685	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
76869006686	ABC-ATPase subunit  interface; other site
76869006687	dimer interface [polypeptide binding]; other site
76869006688	putative PBP binding regions; other site
76869006689	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
76869006690	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
76869006691	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
76869006692	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
76869006693	metal binding site [ion binding]; metal-binding site
76869006694	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
76869006695	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
76869006696	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
76869006697	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
76869006698	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
76869006699	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869006700	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
76869006701	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
76869006702	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869006703	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
76869006704	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
76869006705	putative NAD(P) binding site [chemical binding]; other site
76869006706	putative active site [active]
76869006707	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
76869006708	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
76869006709	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
76869006710	homotrimer interaction site [polypeptide binding]; other site
76869006711	putative active site [active]
76869006712	acetolactate synthase; Reviewed; Region: PRK08322
76869006713	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869006714	PYR/PP interface [polypeptide binding]; other site
76869006715	dimer interface [polypeptide binding]; other site
76869006716	TPP binding site [chemical binding]; other site
76869006717	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869006718	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
76869006719	TPP-binding site [chemical binding]; other site
76869006720	dimer interface [polypeptide binding]; other site
76869006721	Alginate lyase; Region: Alginate_lyase2; pfam08787
76869006722	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
76869006723	Predicted transcriptional regulator [Transcription]; Region: COG2932
76869006724	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869006725	Catalytic site [active]
76869006726	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
76869006727	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
76869006728	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
76869006729	shikimate binding site; other site
76869006730	NAD(P) binding site [chemical binding]; other site
76869006731	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
76869006732	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869006733	dimer interface [polypeptide binding]; other site
76869006734	active site
76869006735	metal binding site [ion binding]; metal-binding site
76869006736	glutathione binding site [chemical binding]; other site
76869006737	outer membrane porin, OprD family; Region: OprD; pfam03573
76869006738	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
76869006739	active site
76869006740	SAM binding site [chemical binding]; other site
76869006741	homodimer interface [polypeptide binding]; other site
76869006742	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006744	active site
76869006745	phosphorylation site [posttranslational modification]
76869006746	intermolecular recognition site; other site
76869006747	dimerization interface [polypeptide binding]; other site
76869006748	CHASE3 domain; Region: CHASE3; pfam05227
76869006749	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
76869006750	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
76869006751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869006752	dimer interface [polypeptide binding]; other site
76869006753	phosphorylation site [posttranslational modification]
76869006754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006755	ATP binding site [chemical binding]; other site
76869006756	Mg2+ binding site [ion binding]; other site
76869006757	G-X-G motif; other site
76869006758	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006760	active site
76869006761	phosphorylation site [posttranslational modification]
76869006762	intermolecular recognition site; other site
76869006763	dimerization interface [polypeptide binding]; other site
76869006764	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006766	active site
76869006767	phosphorylation site [posttranslational modification]
76869006768	intermolecular recognition site; other site
76869006769	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006771	active site
76869006772	phosphorylation site [posttranslational modification]
76869006773	intermolecular recognition site; other site
76869006774	dimerization interface [polypeptide binding]; other site
76869006775	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
76869006776	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
76869006777	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
76869006778	CheB methylesterase; Region: CheB_methylest; pfam01339
76869006779	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006781	active site
76869006782	phosphorylation site [posttranslational modification]
76869006783	intermolecular recognition site; other site
76869006784	dimerization interface [polypeptide binding]; other site
76869006785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869006786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869006787	dimer interface [polypeptide binding]; other site
76869006788	phosphorylation site [posttranslational modification]
76869006789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006790	ATP binding site [chemical binding]; other site
76869006791	Mg2+ binding site [ion binding]; other site
76869006792	G-X-G motif; other site
76869006793	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006795	active site
76869006796	phosphorylation site [posttranslational modification]
76869006797	intermolecular recognition site; other site
76869006798	dimerization interface [polypeptide binding]; other site
76869006799	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869006800	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869006801	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
76869006802	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
76869006803	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
76869006804	beta-ketothiolase; Provisional; Region: PRK09051
76869006805	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869006806	dimer interface [polypeptide binding]; other site
76869006807	active site
76869006808	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869006809	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869006810	SurA N-terminal domain; Region: SurA_N; pfam09312
76869006811	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869006812	Uncharacterized conserved protein [Function unknown]; Region: COG2128
76869006813	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
76869006814	putative cyanate transporter; Provisional; Region: cynX; PRK09705
76869006815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006816	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869006817	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869006818	DNA-binding site [nucleotide binding]; DNA binding site
76869006819	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869006820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869006821	homodimer interface [polypeptide binding]; other site
76869006822	catalytic residue [active]
76869006823	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
76869006824	Domain of unknown function (DUF336); Region: DUF336; cl01249
76869006825	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
76869006826	Cysteine-rich domain; Region: CCG; pfam02754
76869006827	Cysteine-rich domain; Region: CCG; pfam02754
76869006828	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
76869006829	FAD binding domain; Region: FAD_binding_4; pfam01565
76869006830	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
76869006831	FAD binding domain; Region: FAD_binding_4; pfam01565
76869006832	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
76869006833	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869006834	DNA-binding site [nucleotide binding]; DNA binding site
76869006835	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869006836	conserverd hypothetical protein; Region: TIGR02448
76869006837	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
76869006838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869006839	Walker A motif; other site
76869006840	ATP binding site [chemical binding]; other site
76869006841	Walker B motif; other site
76869006842	arginine finger; other site
76869006843	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
76869006844	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
76869006845	Flavin binding site [chemical binding]; other site
76869006846	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869006847	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
76869006848	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
76869006849	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
76869006850	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
76869006851	benzoate transport; Region: 2A0115; TIGR00895
76869006852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869006853	outer membrane porin, OprD family; Region: OprD; pfam03573
76869006854	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869006855	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869006856	DNA-binding site [nucleotide binding]; DNA binding site
76869006857	FCD domain; Region: FCD; pfam07729
76869006858	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
76869006859	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
76869006860	FMN-binding pocket [chemical binding]; other site
76869006861	flavin binding motif; other site
76869006862	phosphate binding motif [ion binding]; other site
76869006863	beta-alpha-beta structure motif; other site
76869006864	NAD binding pocket [chemical binding]; other site
76869006865	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
76869006866	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869006867	catalytic loop [active]
76869006868	iron binding site [ion binding]; other site
76869006869	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
76869006870	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
76869006871	iron-sulfur cluster [ion binding]; other site
76869006872	[2Fe-2S] cluster binding site [ion binding]; other site
76869006873	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
76869006874	alpha subunit interface [polypeptide binding]; other site
76869006875	active site
76869006876	substrate binding site [chemical binding]; other site
76869006877	Fe binding site [ion binding]; other site
76869006878	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
76869006879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
76869006880	Walker A/P-loop; other site
76869006881	ATP binding site [chemical binding]; other site
76869006882	Q-loop/lid; other site
76869006883	ABC transporter signature motif; other site
76869006884	Walker B; other site
76869006885	D-loop; other site
76869006886	H-loop/switch region; other site
76869006887	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
76869006888	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
76869006889	FtsX-like permease family; Region: FtsX; pfam02687
76869006890	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
76869006891	enoyl-CoA hydratase; Provisional; Region: PRK06688
76869006892	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869006893	substrate binding site [chemical binding]; other site
76869006894	oxyanion hole (OAH) forming residues; other site
76869006895	trimer interface [polypeptide binding]; other site
76869006896	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
76869006897	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869006898	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
76869006899	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
76869006900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006901	active site
76869006902	phosphorylation site [posttranslational modification]
76869006903	intermolecular recognition site; other site
76869006904	dimerization interface [polypeptide binding]; other site
76869006905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869006906	DNA binding site [nucleotide binding]
76869006907	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869006908	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869006909	substrate binding pocket [chemical binding]; other site
76869006910	membrane-bound complex binding site; other site
76869006911	hinge residues; other site
76869006912	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869006913	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869006914	dimer interface [polypeptide binding]; other site
76869006915	phosphorylation site [posttranslational modification]
76869006916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869006917	ATP binding site [chemical binding]; other site
76869006918	Mg2+ binding site [ion binding]; other site
76869006919	G-X-G motif; other site
76869006920	Response regulator receiver domain; Region: Response_reg; pfam00072
76869006921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869006922	active site
76869006923	phosphorylation site [posttranslational modification]
76869006924	intermolecular recognition site; other site
76869006925	dimerization interface [polypeptide binding]; other site
76869006926	S-methylmethionine transporter; Provisional; Region: PRK11387
76869006927	enoyl-CoA hydratase; Provisional; Region: PRK06688
76869006928	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869006929	substrate binding site [chemical binding]; other site
76869006930	oxyanion hole (OAH) forming residues; other site
76869006931	trimer interface [polypeptide binding]; other site
76869006932	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869006933	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869006934	active site
76869006935	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
76869006936	CoA binding domain; Region: CoA_binding_2; pfam13380
76869006937	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
76869006938	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
76869006939	hypothetical protein; Provisional; Region: PRK07524
76869006940	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869006941	PYR/PP interface [polypeptide binding]; other site
76869006942	dimer interface [polypeptide binding]; other site
76869006943	TPP binding site [chemical binding]; other site
76869006944	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869006945	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
76869006946	TPP-binding site [chemical binding]; other site
76869006947	alanine racemase; Reviewed; Region: PRK13340
76869006948	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826
76869006949	active site
76869006950	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869006951	dimer interface [polypeptide binding]; other site
76869006952	substrate binding site [chemical binding]; other site
76869006953	catalytic residues [active]
76869006954	aspartate aminotransferase; Provisional; Region: PRK05764
76869006955	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869006956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869006957	homodimer interface [polypeptide binding]; other site
76869006958	catalytic residue [active]
76869006959	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
76869006960	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869006961	NAD binding site [chemical binding]; other site
76869006962	catalytic residues [active]
76869006963	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
76869006964	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869006965	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869006966	hypothetical protein; Provisional; Region: PRK07036
76869006967	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869006968	inhibitor-cofactor binding pocket; inhibition site
76869006969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869006970	catalytic residue [active]
76869006971	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869006972	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869006973	DNA binding residues [nucleotide binding]
76869006974	dimerization interface [polypeptide binding]; other site
76869006975	Fic family protein [Function unknown]; Region: COG3177
76869006976	Fic/DOC family; Region: Fic; pfam02661
76869006977	transcriptional repressor DicA; Reviewed; Region: PRK09706
76869006978	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869006979	sequence-specific DNA binding site [nucleotide binding]; other site
76869006980	salt bridge; other site
76869006981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869006982	PAS fold; Region: PAS_3; pfam08447
76869006983	putative active site [active]
76869006984	heme pocket [chemical binding]; other site
76869006985	PAS domain S-box; Region: sensory_box; TIGR00229
76869006986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869006987	putative active site [active]
76869006988	heme pocket [chemical binding]; other site
76869006989	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
76869006990	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
76869006991	FMN-binding pocket [chemical binding]; other site
76869006992	flavin binding motif; other site
76869006993	phosphate binding motif [ion binding]; other site
76869006994	beta-alpha-beta structure motif; other site
76869006995	NAD binding pocket [chemical binding]; other site
76869006996	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869006997	catalytic loop [active]
76869006998	iron binding site [ion binding]; other site
76869006999	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
76869007000	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
76869007001	[2Fe-2S] cluster binding site [ion binding]; other site
76869007002	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
76869007003	putative alpha subunit interface [polypeptide binding]; other site
76869007004	putative active site [active]
76869007005	putative substrate binding site [chemical binding]; other site
76869007006	Fe binding site [ion binding]; other site
76869007007	putative transporter; Provisional; Region: PRK09950
76869007008	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
76869007009	tartrate dehydrogenase; Region: TTC; TIGR02089
76869007010	transcriptional activator TtdR; Provisional; Region: PRK09801
76869007011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007012	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
76869007013	putative effector binding pocket; other site
76869007014	putative dimerization interface [polypeptide binding]; other site
76869007015	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869007016	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
76869007017	AsnC family; Region: AsnC_trans_reg; pfam01037
76869007018	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
76869007019	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
76869007020	active site
76869007021	Zn binding site [ion binding]; other site
76869007022	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
76869007023	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
76869007024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007025	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
76869007026	dimerizarion interface [polypeptide binding]; other site
76869007027	CrgA pocket; other site
76869007028	substrate binding pocket [chemical binding]; other site
76869007029	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
76869007030	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
76869007031	octamer interface [polypeptide binding]; other site
76869007032	active site
76869007033	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
76869007034	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
76869007035	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
76869007036	dimer interface [polypeptide binding]; other site
76869007037	active site
76869007038	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869007039	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869007040	active site
76869007041	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
76869007042	[2Fe-2S] cluster binding site [ion binding]; other site
76869007043	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
76869007044	putative alpha subunit interface [polypeptide binding]; other site
76869007045	putative active site [active]
76869007046	putative substrate binding site [chemical binding]; other site
76869007047	Fe binding site [ion binding]; other site
76869007048	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
76869007049	inter-subunit interface; other site
76869007050	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
76869007051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869007052	NAD(P) binding site [chemical binding]; other site
76869007053	active site
76869007054	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
76869007055	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
76869007056	FMN-binding pocket [chemical binding]; other site
76869007057	flavin binding motif; other site
76869007058	phosphate binding motif [ion binding]; other site
76869007059	beta-alpha-beta structure motif; other site
76869007060	NAD binding pocket [chemical binding]; other site
76869007061	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869007062	catalytic loop [active]
76869007063	iron binding site [ion binding]; other site
76869007064	Flavin Reductases; Region: FlaRed; cl00801
76869007065	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869007066	MarR family; Region: MarR_2; cl17246
76869007067	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
76869007068	Amidase; Region: Amidase; cl11426
76869007069	SnoaL-like domain; Region: SnoaL_4; pfam13577
76869007070	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
76869007071	Cytochrome c; Region: Cytochrom_C; cl11414
76869007072	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
76869007073	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007074	Cytochrome c; Region: Cytochrom_C; cl11414
76869007075	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
76869007076	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
76869007077	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869007078	Methylamine utilisation protein MauE; Region: MauE; pfam07291
76869007079	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
76869007080	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869007081	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869007082	NAD(P) binding site [chemical binding]; other site
76869007083	catalytic residues [active]
76869007084	Predicted acetyltransferase [General function prediction only]; Region: COG5628
76869007085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869007086	PAS domain; Region: PAS_9; pfam13426
76869007087	putative active site [active]
76869007088	heme pocket [chemical binding]; other site
76869007089	PAS fold; Region: PAS_4; pfam08448
76869007090	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869007091	putative active site [active]
76869007092	heme pocket [chemical binding]; other site
76869007093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869007094	metal binding site [ion binding]; metal-binding site
76869007095	active site
76869007096	I-site; other site
76869007097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869007098	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869007099	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869007100	active site
76869007101	catalytic tetrad [active]
76869007102	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869007103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007105	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
76869007106	putative substrate binding pocket [chemical binding]; other site
76869007107	putative dimerization interface [polypeptide binding]; other site
76869007108	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
76869007109	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
76869007110	dimer interface [polypeptide binding]; other site
76869007111	active site
76869007112	heme binding site [chemical binding]; other site
76869007113	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
76869007114	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
76869007115	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
76869007116	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
76869007117	active site
76869007118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869007119	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869007120	putative substrate translocation pore; other site
76869007121	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869007122	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869007123	conserved cys residue [active]
76869007124	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007125	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
76869007126	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
76869007127	domain interface [polypeptide binding]; other site
76869007128	putative active site [active]
76869007129	catalytic site [active]
76869007130	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
76869007131	putative active site [active]
76869007132	catalytic site [active]
76869007133	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869007134	EamA-like transporter family; Region: EamA; pfam00892
76869007135	EamA-like transporter family; Region: EamA; pfam00892
76869007136	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007138	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
76869007139	putative dimerization interface [polypeptide binding]; other site
76869007140	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869007141	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869007142	metal binding site [ion binding]; metal-binding site
76869007143	active site
76869007144	I-site; other site
76869007145	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869007146	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
76869007147	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
76869007148	Predicted membrane protein [Function unknown]; Region: COG2855
76869007149	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007150	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007151	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
76869007152	putative dimerization interface [polypeptide binding]; other site
76869007153	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869007154	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869007155	EamA-like transporter family; Region: EamA; cl17759
76869007156	EamA-like transporter family; Region: EamA; pfam00892
76869007157	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
76869007158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869007159	non-specific DNA binding site [nucleotide binding]; other site
76869007160	salt bridge; other site
76869007161	sequence-specific DNA binding site [nucleotide binding]; other site
76869007162	Cupin domain; Region: Cupin_2; pfam07883
76869007163	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
76869007164	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869007165	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
76869007166	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
76869007167	putative active site [active]
76869007168	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
76869007169	domain_subunit interface; other site
76869007170	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
76869007171	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
76869007172	active site
76869007173	FMN binding site [chemical binding]; other site
76869007174	substrate binding site [chemical binding]; other site
76869007175	3Fe-4S cluster binding site [ion binding]; other site
76869007176	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
76869007177	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
76869007178	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869007179	Na binding site [ion binding]; other site
76869007180	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869007181	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869007182	putative DNA binding site [nucleotide binding]; other site
76869007183	putative Zn2+ binding site [ion binding]; other site
76869007184	AsnC family; Region: AsnC_trans_reg; pfam01037
76869007185	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869007186	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869007187	PAS fold; Region: PAS_4; pfam08448
76869007188	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
76869007189	GAF domain; Region: GAF; pfam01590
76869007190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869007191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869007192	dimer interface [polypeptide binding]; other site
76869007193	phosphorylation site [posttranslational modification]
76869007194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007195	ATP binding site [chemical binding]; other site
76869007196	Mg2+ binding site [ion binding]; other site
76869007197	G-X-G motif; other site
76869007198	Response regulator receiver domain; Region: Response_reg; pfam00072
76869007199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007200	active site
76869007201	phosphorylation site [posttranslational modification]
76869007202	intermolecular recognition site; other site
76869007203	dimerization interface [polypeptide binding]; other site
76869007204	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582
76869007205	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
76869007206	active site
76869007207	active site
76869007208	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
76869007209	nudix motif; other site
76869007210	Transcriptional regulators [Transcription]; Region: GntR; COG1802
76869007211	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869007212	DNA-binding site [nucleotide binding]; DNA binding site
76869007213	FCD domain; Region: FCD; pfam07729
76869007214	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
76869007215	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
76869007216	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869007217	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
76869007218	NAD(P) binding site [chemical binding]; other site
76869007219	catalytic residues [active]
76869007220	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
76869007221	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
76869007222	Amino acid synthesis; Region: AA_synth; pfam06684
76869007223	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
76869007224	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
76869007225	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
76869007226	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
76869007227	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869007228	Na binding site [ion binding]; other site
76869007229	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
76869007230	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869007231	dimerization interface [polypeptide binding]; other site
76869007232	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869007233	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869007234	dimer interface [polypeptide binding]; other site
76869007235	putative CheW interface [polypeptide binding]; other site
76869007236	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
76869007237	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869007238	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
76869007239	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869007240	Predicted transcriptional regulator [Transcription]; Region: COG1959
76869007241	Transcriptional regulator; Region: Rrf2; pfam02082
76869007242	Cupin; Region: Cupin_6; pfam12852
76869007243	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869007244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007245	Uncharacterized conserved protein [Function unknown]; Region: COG2128
76869007246	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
76869007247	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869007248	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869007249	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
76869007250	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869007251	Walker A/P-loop; other site
76869007252	ATP binding site [chemical binding]; other site
76869007253	Q-loop/lid; other site
76869007254	ABC transporter signature motif; other site
76869007255	Walker B; other site
76869007256	D-loop; other site
76869007257	H-loop/switch region; other site
76869007258	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
76869007259	NMT1-like family; Region: NMT1_2; pfam13379
76869007260	NMT1/THI5 like; Region: NMT1; pfam09084
76869007261	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869007262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869007263	dimer interface [polypeptide binding]; other site
76869007264	conserved gate region; other site
76869007265	putative PBP binding loops; other site
76869007266	ABC-ATPase subunit interface; other site
76869007267	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
76869007268	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869007269	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869007270	Coenzyme A binding pocket [chemical binding]; other site
76869007271	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
76869007272	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
76869007273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007275	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869007276	dimerization interface [polypeptide binding]; other site
76869007277	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
76869007278	active site 1 [active]
76869007279	dimer interface [polypeptide binding]; other site
76869007280	hexamer interface [polypeptide binding]; other site
76869007281	active site 2 [active]
76869007282	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
76869007283	classical (c) SDRs; Region: SDR_c; cd05233
76869007284	NAD(P) binding site [chemical binding]; other site
76869007285	active site
76869007286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007288	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869007289	putative effector binding pocket; other site
76869007290	dimerization interface [polypeptide binding]; other site
76869007291	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
76869007292	Bacterial SH3 domain; Region: SH3_3; pfam08239
76869007293	outer membrane porin, OprD family; Region: OprD; pfam03573
76869007294	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
76869007295	dimer interface [polypeptide binding]; other site
76869007296	BCCT family transporter; Region: BCCT; pfam02028
76869007297	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
76869007298	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869007299	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869007300	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869007301	substrate binding pocket [chemical binding]; other site
76869007302	membrane-bound complex binding site; other site
76869007303	hinge residues; other site
76869007304	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
76869007305	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
76869007306	XdhC Rossmann domain; Region: XdhC_C; pfam13478
76869007307	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869007308	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869007309	Cytochrome c; Region: Cytochrom_C; pfam00034
76869007310	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
76869007311	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869007312	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
76869007313	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869007314	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869007315	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
76869007316	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869007317	catalytic loop [active]
76869007318	iron binding site [ion binding]; other site
76869007319	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
76869007320	YcaO domain protein; Region: TIGR03549
76869007321	OsmC-like protein; Region: OsmC; pfam02566
76869007322	YcaO-like family; Region: YcaO; pfam02624
76869007323	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
76869007324	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
76869007325	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
76869007326	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
76869007327	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869007328	N-terminal plug; other site
76869007329	ligand-binding site [chemical binding]; other site
76869007330	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
76869007331	Protein of unknown function, DUF606; Region: DUF606; pfam04657
76869007332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007334	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
76869007335	putative substrate binding pocket [chemical binding]; other site
76869007336	putative dimerization interface [polypeptide binding]; other site
76869007337	Sulphur transport; Region: Sulf_transp; pfam04143
76869007338	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
76869007339	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
76869007340	NADP binding site [chemical binding]; other site
76869007341	dimer interface [polypeptide binding]; other site
76869007342	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007344	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869007345	putative effector binding pocket; other site
76869007346	dimerization interface [polypeptide binding]; other site
76869007347	Protein of unknown function (DUF998); Region: DUF998; pfam06197
76869007348	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869007349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869007350	DNA-binding site [nucleotide binding]; DNA binding site
76869007351	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869007352	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
76869007353	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
76869007354	dimer interface [polypeptide binding]; other site
76869007355	NADP binding site [chemical binding]; other site
76869007356	catalytic residues [active]
76869007357	galactarate dehydratase; Region: galactar-dH20; TIGR03248
76869007358	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
76869007359	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
76869007360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869007361	D-galactonate transporter; Region: 2A0114; TIGR00893
76869007362	putative substrate translocation pore; other site
76869007363	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
76869007364	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
76869007365	putative active site [active]
76869007366	catalytic residue [active]
76869007367	Peptidase C26; Region: Peptidase_C26; pfam07722
76869007368	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
76869007369	catalytic triad [active]
76869007370	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869007371	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869007372	Walker A/P-loop; other site
76869007373	ATP binding site [chemical binding]; other site
76869007374	Q-loop/lid; other site
76869007375	ABC transporter signature motif; other site
76869007376	Walker B; other site
76869007377	D-loop; other site
76869007378	H-loop/switch region; other site
76869007379	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869007380	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869007381	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869007382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869007383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869007384	dimer interface [polypeptide binding]; other site
76869007385	putative PBP binding loops; other site
76869007386	ABC-ATPase subunit interface; other site
76869007387	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869007388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869007389	dimer interface [polypeptide binding]; other site
76869007390	conserved gate region; other site
76869007391	putative PBP binding loops; other site
76869007392	ABC-ATPase subunit interface; other site
76869007393	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869007394	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869007395	substrate binding pocket [chemical binding]; other site
76869007396	membrane-bound complex binding site; other site
76869007397	hinge residues; other site
76869007398	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
76869007399	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
76869007400	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
76869007401	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
76869007402	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
76869007403	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869007404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869007405	homodimer interface [polypeptide binding]; other site
76869007406	catalytic residue [active]
76869007407	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
76869007408	serine transporter; Region: stp; TIGR00814
76869007409	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
76869007410	dimer interface [polypeptide binding]; other site
76869007411	catalytic triad [active]
76869007412	peroxidatic and resolving cysteines [active]
76869007413	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869007414	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
76869007415	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869007416	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
76869007417	Protein export membrane protein; Region: SecD_SecF; cl14618
76869007418	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
76869007419	Protein export membrane protein; Region: SecD_SecF; cl14618
76869007420	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
76869007421	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
76869007422	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
76869007423	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
76869007424	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869007425	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869007426	metal binding site [ion binding]; metal-binding site
76869007427	active site
76869007428	I-site; other site
76869007429	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869007430	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
76869007431	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
76869007432	phosphoglucomutase; Validated; Region: PRK07564
76869007433	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
76869007434	active site
76869007435	substrate binding site [chemical binding]; other site
76869007436	metal binding site [ion binding]; metal-binding site
76869007437	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869007438	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869007439	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869007440	DNA binding residues [nucleotide binding]
76869007441	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869007442	FecR protein; Region: FecR; pfam04773
76869007443	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869007444	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869007445	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869007446	N-terminal plug; other site
76869007447	ligand-binding site [chemical binding]; other site
76869007448	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
76869007449	Leucine-rich repeats; other site
76869007450	Substrate binding site [chemical binding]; other site
76869007451	Leucine rich repeat; Region: LRR_8; pfam13855
76869007452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869007455	dimerization interface [polypeptide binding]; other site
76869007456	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
76869007457	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
76869007458	active site
76869007459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869007460	D-galactonate transporter; Region: 2A0114; TIGR00893
76869007461	putative substrate translocation pore; other site
76869007462	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
76869007463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869007464	NAD(P) binding site [chemical binding]; other site
76869007465	active site
76869007466	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
76869007467	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
76869007468	homotrimer interaction site [polypeptide binding]; other site
76869007469	putative active site [active]
76869007470	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
76869007471	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869007472	Uncharacterized conserved protein [Function unknown]; Region: COG3342
76869007473	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
76869007474	acetylornithine deacetylase; Provisional; Region: PRK07522
76869007475	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
76869007476	metal binding site [ion binding]; metal-binding site
76869007477	putative dimer interface [polypeptide binding]; other site
76869007478	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
76869007479	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
76869007480	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
76869007481	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
76869007482	Trp docking motif [polypeptide binding]; other site
76869007483	putative active site [active]
76869007484	Cupin domain; Region: Cupin_2; cl17218
76869007485	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007486	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007487	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869007488	putative effector binding pocket; other site
76869007489	dimerization interface [polypeptide binding]; other site
76869007490	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869007491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869007492	LysE type translocator; Region: LysE; cl00565
76869007493	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869007494	conserved cys residue [active]
76869007495	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869007496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007497	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
76869007498	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
76869007499	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
76869007500	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
76869007501	Membrane transport protein; Region: Mem_trans; cl09117
76869007502	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007504	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
76869007505	putative dimerization interface [polypeptide binding]; other site
76869007506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869007507	dimer interface [polypeptide binding]; other site
76869007508	conserved gate region; other site
76869007509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869007510	ABC-ATPase subunit interface; other site
76869007511	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
76869007512	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
76869007513	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
76869007514	putative active site [active]
76869007515	putative catalytic triad [active]
76869007516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869007517	dimerization interface [polypeptide binding]; other site
76869007518	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869007519	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869007520	dimer interface [polypeptide binding]; other site
76869007521	putative CheW interface [polypeptide binding]; other site
76869007522	Predicted permease [General function prediction only]; Region: COG2056
76869007523	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
76869007524	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869007525	FecR protein; Region: FecR; pfam04773
76869007526	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
76869007527	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
76869007528	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869007529	active site
76869007530	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
76869007531	acyl-CoA synthetase; Validated; Region: PRK08162
76869007532	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
76869007533	acyl-activating enzyme (AAE) consensus motif; other site
76869007534	putative active site [active]
76869007535	AMP binding site [chemical binding]; other site
76869007536	putative CoA binding site [chemical binding]; other site
76869007537	PAS domain S-box; Region: sensory_box; TIGR00229
76869007538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869007539	putative active site [active]
76869007540	heme pocket [chemical binding]; other site
76869007541	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869007542	dimer interface [polypeptide binding]; other site
76869007543	phosphorylation site [posttranslational modification]
76869007544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007545	ATP binding site [chemical binding]; other site
76869007546	G-X-G motif; other site
76869007547	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
76869007548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007549	active site
76869007550	phosphorylation site [posttranslational modification]
76869007551	intermolecular recognition site; other site
76869007552	dimerization interface [polypeptide binding]; other site
76869007553	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869007554	DNA binding residues [nucleotide binding]
76869007555	dimerization interface [polypeptide binding]; other site
76869007556	MarR family; Region: MarR_2; cl17246
76869007557	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869007558	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
76869007559	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869007560	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869007561	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
76869007562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869007563	putative substrate translocation pore; other site
76869007564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869007565	short chain dehydrogenase; Provisional; Region: PRK06123
76869007566	classical (c) SDRs; Region: SDR_c; cd05233
76869007567	NAD(P) binding site [chemical binding]; other site
76869007568	active site
76869007569	PAS fold; Region: PAS_7; pfam12860
76869007570	PAS fold; Region: PAS_4; pfam08448
76869007571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007572	ATP binding site [chemical binding]; other site
76869007573	Mg2+ binding site [ion binding]; other site
76869007574	G-X-G motif; other site
76869007575	Response regulator receiver domain; Region: Response_reg; pfam00072
76869007576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007577	active site
76869007578	phosphorylation site [posttranslational modification]
76869007579	intermolecular recognition site; other site
76869007580	dimerization interface [polypeptide binding]; other site
76869007581	PAS fold; Region: PAS_4; pfam08448
76869007582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869007583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007584	ATP binding site [chemical binding]; other site
76869007585	Mg2+ binding site [ion binding]; other site
76869007586	G-X-G motif; other site
76869007587	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869007588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007589	active site
76869007590	phosphorylation site [posttranslational modification]
76869007591	intermolecular recognition site; other site
76869007592	dimerization interface [polypeptide binding]; other site
76869007593	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869007594	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869007595	DNA-binding site [nucleotide binding]; DNA binding site
76869007596	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869007597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869007598	homodimer interface [polypeptide binding]; other site
76869007599	catalytic residue [active]
76869007600	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
76869007601	4Fe-4S binding domain; Region: Fer4_5; pfam12801
76869007602	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
76869007603	Protein of unknown function (DUF3203); Region: DUF3203; pfam11462
76869007604	MgtC family; Region: MgtC; pfam02308
76869007605	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
76869007606	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
76869007607	active site
76869007608	catalytic residues [active]
76869007609	metal binding site [ion binding]; metal-binding site
76869007610	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
76869007611	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
76869007612	DNA binding residues [nucleotide binding]
76869007613	putative dimer interface [polypeptide binding]; other site
76869007614	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869007615	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869007616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007617	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
76869007618	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869007619	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
76869007620	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
76869007621	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
76869007622	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
76869007623	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
76869007624	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007626	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869007627	dimerization interface [polypeptide binding]; other site
76869007628	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
76869007629	Amidinotransferase; Region: Amidinotransf; pfam02274
76869007630	ornithine cyclodeaminase; Validated; Region: PRK07589
76869007631	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
76869007632	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869007633	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
76869007634	AsnC family; Region: AsnC_trans_reg; pfam01037
76869007635	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
76869007636	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
76869007637	putative lipid binding site [chemical binding]; other site
76869007638	hypothetical protein; Provisional; Region: PRK11171
76869007639	Cupin domain; Region: Cupin_2; pfam07883
76869007640	Cupin domain; Region: Cupin_2; pfam07883
76869007641	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
76869007642	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869007643	active site
76869007644	non-prolyl cis peptide bond; other site
76869007645	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869007646	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869007647	substrate binding pocket [chemical binding]; other site
76869007648	membrane-bound complex binding site; other site
76869007649	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
76869007650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869007651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869007652	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869007653	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869007654	conserved cys residue [active]
76869007655	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007656	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
76869007657	homotrimer interaction site [polypeptide binding]; other site
76869007658	putative active site [active]
76869007659	EamA-like transporter family; Region: EamA; cl17759
76869007660	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
76869007661	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
76869007662	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
76869007663	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869007664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007665	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
76869007666	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
76869007667	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
76869007668	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
76869007669	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
76869007670	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869007671	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007672	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869007673	dimerization interface [polypeptide binding]; other site
76869007674	Predicted membrane protein [Function unknown]; Region: COG4125
76869007675	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
76869007676	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
76869007677	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
76869007678	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
76869007679	homodimer interface [polypeptide binding]; other site
76869007680	substrate-cofactor binding pocket; other site
76869007681	catalytic residue [active]
76869007682	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
76869007683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869007684	Walker A/P-loop; other site
76869007685	ATP binding site [chemical binding]; other site
76869007686	Q-loop/lid; other site
76869007687	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869007688	ABC transporter signature motif; other site
76869007689	Walker B; other site
76869007690	D-loop; other site
76869007691	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869007692	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
76869007693	dimer interface [polypeptide binding]; other site
76869007694	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869007695	ligand binding site [chemical binding]; other site
76869007696	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
76869007697	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
76869007698	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
76869007699	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
76869007700	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
76869007701	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
76869007702	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
76869007703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869007704	Walker A motif; other site
76869007705	ATP binding site [chemical binding]; other site
76869007706	Walker B motif; other site
76869007707	arginine finger; other site
76869007708	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
76869007709	metal ion-dependent adhesion site (MIDAS); other site
76869007710	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869007711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869007712	Walker A motif; other site
76869007713	ATP binding site [chemical binding]; other site
76869007714	Walker B motif; other site
76869007715	arginine finger; other site
76869007716	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869007717	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869007718	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869007719	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869007720	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
76869007721	Protein export membrane protein; Region: SecD_SecF; cl14618
76869007722	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
76869007723	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869007724	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
76869007725	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
76869007726	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
76869007727	Peptidase family U32; Region: Peptidase_U32; pfam01136
76869007728	Collagenase; Region: DUF3656; pfam12392
76869007729	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
76869007730	homotrimer interaction site [polypeptide binding]; other site
76869007731	putative active site [active]
76869007732	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
76869007733	Family of unknown function (DUF633); Region: DUF633; pfam04816
76869007734	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869007735	transcriptional regulator; Provisional; Region: PRK10632
76869007736	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869007737	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869007738	putative effector binding pocket; other site
76869007739	dimerization interface [polypeptide binding]; other site
76869007740	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869007741	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869007742	active site
76869007743	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
76869007744	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869007745	substrate binding site [chemical binding]; other site
76869007746	oxyanion hole (OAH) forming residues; other site
76869007747	trimer interface [polypeptide binding]; other site
76869007748	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
76869007749	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
76869007750	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
76869007751	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
76869007752	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
76869007753	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
76869007754	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
76869007755	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
76869007756	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
76869007757	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
76869007758	Malonate transporter MadL subunit; Region: MadL; cl04273
76869007759	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
76869007760	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
76869007761	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
76869007762	structural tetrad; other site
76869007763	FixH; Region: FixH; pfam05751
76869007764	YtkA-like; Region: YtkA; pfam13115
76869007765	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
76869007766	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
76869007767	Cu(I) binding site [ion binding]; other site
76869007768	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
76869007769	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
76869007770	Cu(I) binding site [ion binding]; other site
76869007771	Cytochrome c; Region: Cytochrom_C; pfam00034
76869007772	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
76869007773	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
76869007774	ligand binding site [chemical binding]; other site
76869007775	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
76869007776	SurA N-terminal domain; Region: SurA_N_3; cl07813
76869007777	Response regulator receiver domain; Region: Response_reg; pfam00072
76869007778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007779	active site
76869007780	phosphorylation site [posttranslational modification]
76869007781	intermolecular recognition site; other site
76869007782	dimerization interface [polypeptide binding]; other site
76869007783	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
76869007784	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
76869007785	Walker A motif; other site
76869007786	ATP binding site [chemical binding]; other site
76869007787	Walker B motif; other site
76869007788	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
76869007789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869007790	TPR motif; other site
76869007791	binding surface
76869007792	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
76869007793	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869007794	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
76869007795	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
76869007796	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
76869007797	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
76869007798	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
76869007799	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
76869007800	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
76869007801	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
76869007802	curli assembly protein CsgE; Provisional; Region: PRK10386
76869007803	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
76869007804	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
76869007805	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869007806	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283
76869007807	nad+ binding pocket [chemical binding]; other site
76869007808	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
76869007809	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
76869007810	GAF domain; Region: GAF; pfam01590
76869007811	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869007812	putative active site [active]
76869007813	heme pocket [chemical binding]; other site
76869007814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869007815	ATP binding site [chemical binding]; other site
76869007816	Walker A motif; other site
76869007817	Walker B motif; other site
76869007818	arginine finger; other site
76869007819	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869007820	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
76869007821	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869007822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869007823	Walker A/P-loop; other site
76869007824	ATP binding site [chemical binding]; other site
76869007825	Q-loop/lid; other site
76869007826	ABC transporter signature motif; other site
76869007827	Walker B; other site
76869007828	D-loop; other site
76869007829	H-loop/switch region; other site
76869007830	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
76869007831	active site
76869007832	catalytic residues [active]
76869007833	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
76869007834	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
76869007835	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869007836	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869007837	NAD(P) binding site [chemical binding]; other site
76869007838	catalytic residues [active]
76869007839	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
76869007840	Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098
76869007841	Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099
76869007842	Domain of unknown function (DUF1928); Region: DUF1928; pfam09100
76869007843	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
76869007844	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869007845	FeS/SAM binding site; other site
76869007846	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
76869007847	Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992
76869007848	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
76869007849	acyl-CoA synthetase; Provisional; Region: PRK12583
76869007850	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
76869007851	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
76869007852	acyl-activating enzyme (AAE) consensus motif; other site
76869007853	putative AMP binding site [chemical binding]; other site
76869007854	putative active site [active]
76869007855	putative CoA binding site [chemical binding]; other site
76869007856	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
76869007857	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
76869007858	GTP binding site; other site
76869007859	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
76869007860	Protein export membrane protein; Region: SecD_SecF; cl14618
76869007861	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
76869007862	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869007863	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869007864	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869007865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007866	active site
76869007867	phosphorylation site [posttranslational modification]
76869007868	intermolecular recognition site; other site
76869007869	dimerization interface [polypeptide binding]; other site
76869007870	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869007871	DNA binding site [nucleotide binding]
76869007872	sensor protein RstB; Provisional; Region: PRK10604
76869007873	HAMP domain; Region: HAMP; pfam00672
76869007874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
76869007875	dimer interface [polypeptide binding]; other site
76869007876	phosphorylation site [posttranslational modification]
76869007877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007878	ATP binding site [chemical binding]; other site
76869007879	Mg2+ binding site [ion binding]; other site
76869007880	G-X-G motif; other site
76869007881	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869007882	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869007883	metal binding site [ion binding]; metal-binding site
76869007884	active site
76869007885	I-site; other site
76869007886	hypothetical protein; Provisional; Region: PRK09936
76869007887	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
76869007888	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
76869007889	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
76869007890	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
76869007891	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
76869007892	Predicted membrane protein [Function unknown]; Region: COG4125
76869007893	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
76869007894	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
76869007895	threonine dehydratase; Reviewed; Region: PRK12483
76869007896	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
76869007897	tetramer interface [polypeptide binding]; other site
76869007898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869007899	catalytic residue [active]
76869007900	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
76869007901	putative Ile/Val binding site [chemical binding]; other site
76869007902	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
76869007903	putative Ile/Val binding site [chemical binding]; other site
76869007904	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
76869007905	putative dimer interface [polypeptide binding]; other site
76869007906	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869007907	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
76869007908	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
76869007909	tetrameric interface [polypeptide binding]; other site
76869007910	activator binding site; other site
76869007911	NADP binding site [chemical binding]; other site
76869007912	substrate binding site [chemical binding]; other site
76869007913	catalytic residues [active]
76869007914	Leucine rich repeat; Region: LRR_8; pfam13855
76869007915	Protein of unknown function (DUF563); Region: DUF563; pfam04577
76869007916	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869007917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007918	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869007919	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869007920	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869007921	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
76869007922	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
76869007923	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
76869007924	Transporter associated domain; Region: CorC_HlyC; smart01091
76869007925	Predicted permeases [General function prediction only]; Region: RarD; COG2962
76869007926	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
76869007927	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
76869007928	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869007929	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
76869007930	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
76869007931	dimer interface [polypeptide binding]; other site
76869007932	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
76869007933	active site
76869007934	Fe binding site [ion binding]; other site
76869007935	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
76869007936	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
76869007937	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
76869007938	potential catalytic triad [active]
76869007939	conserved cys residue [active]
76869007940	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
76869007941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869007942	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
76869007943	putative active site [active]
76869007944	heme pocket [chemical binding]; other site
76869007945	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869007946	dimer interface [polypeptide binding]; other site
76869007947	phosphorylation site [posttranslational modification]
76869007948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007949	ATP binding site [chemical binding]; other site
76869007950	Mg2+ binding site [ion binding]; other site
76869007951	G-X-G motif; other site
76869007952	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869007953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007954	active site
76869007955	phosphorylation site [posttranslational modification]
76869007956	intermolecular recognition site; other site
76869007957	dimerization interface [polypeptide binding]; other site
76869007958	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
76869007959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869007960	ATP binding site [chemical binding]; other site
76869007961	Mg2+ binding site [ion binding]; other site
76869007962	G-X-G motif; other site
76869007963	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869007964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869007965	active site
76869007966	phosphorylation site [posttranslational modification]
76869007967	intermolecular recognition site; other site
76869007968	dimerization interface [polypeptide binding]; other site
76869007969	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869007970	binding surface
76869007971	Tetratricopeptide repeat; Region: TPR_16; pfam13432
76869007972	TPR motif; other site
76869007973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869007974	binding surface
76869007975	TPR motif; other site
76869007976	TPR repeat; Region: TPR_11; pfam13414
76869007977	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869007978	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869007979	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
76869007980	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
76869007981	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869007982	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869007983	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869007984	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
76869007985	active site residue [active]
76869007986	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
76869007987	active site residue [active]
76869007988	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
76869007989	active site residue [active]
76869007990	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
76869007991	active site residue [active]
76869007992	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
76869007993	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869007994	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869007995	substrate binding pocket [chemical binding]; other site
76869007996	membrane-bound complex binding site; other site
76869007997	hinge residues; other site
76869007998	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
76869007999	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869008000	active site
76869008001	non-prolyl cis peptide bond; other site
76869008002	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
76869008003	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
76869008004	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
76869008005	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
76869008006	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
76869008007	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
76869008008	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869008009	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869008010	catalytic residue [active]
76869008011	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869008012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869008013	dimer interface [polypeptide binding]; other site
76869008014	phosphorylation site [posttranslational modification]
76869008015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869008016	ATP binding site [chemical binding]; other site
76869008017	Mg2+ binding site [ion binding]; other site
76869008018	G-X-G motif; other site
76869008019	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869008020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869008021	dimer interface [polypeptide binding]; other site
76869008022	phosphorylation site [posttranslational modification]
76869008023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869008024	ATP binding site [chemical binding]; other site
76869008025	Mg2+ binding site [ion binding]; other site
76869008026	G-X-G motif; other site
76869008027	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869008028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869008029	active site
76869008030	phosphorylation site [posttranslational modification]
76869008031	intermolecular recognition site; other site
76869008032	dimerization interface [polypeptide binding]; other site
76869008033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869008034	Walker A motif; other site
76869008035	ATP binding site [chemical binding]; other site
76869008036	Walker B motif; other site
76869008037	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869008038	hydroperoxidase II; Provisional; Region: katE; PRK11249
76869008039	fructuronate transporter; Provisional; Region: PRK10034; cl15264
76869008040	GntP family permease; Region: GntP_permease; pfam02447
76869008041	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
76869008042	ATP-binding site [chemical binding]; other site
76869008043	Gluconate-6-phosphate binding site [chemical binding]; other site
76869008044	Transcriptional regulators [Transcription]; Region: PurR; COG1609
76869008045	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
76869008046	DNA binding site [nucleotide binding]
76869008047	domain linker motif; other site
76869008048	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
76869008049	putative ligand binding site [chemical binding]; other site
76869008050	putative dimerization interface [polypeptide binding]; other site
76869008051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869008052	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
76869008053	putative active site [active]
76869008054	heme pocket [chemical binding]; other site
76869008055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869008056	putative active site [active]
76869008057	heme pocket [chemical binding]; other site
76869008058	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869008059	dimer interface [polypeptide binding]; other site
76869008060	putative CheW interface [polypeptide binding]; other site
76869008061	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869008062	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869008063	substrate binding pocket [chemical binding]; other site
76869008064	membrane-bound complex binding site; other site
76869008065	hinge residues; other site
76869008066	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869008067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869008068	substrate binding pocket [chemical binding]; other site
76869008069	membrane-bound complex binding site; other site
76869008070	hinge residues; other site
76869008071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869008072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869008073	dimer interface [polypeptide binding]; other site
76869008074	phosphorylation site [posttranslational modification]
76869008075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869008076	ATP binding site [chemical binding]; other site
76869008077	Mg2+ binding site [ion binding]; other site
76869008078	G-X-G motif; other site
76869008079	Response regulator receiver domain; Region: Response_reg; pfam00072
76869008080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869008081	active site
76869008082	phosphorylation site [posttranslational modification]
76869008083	intermolecular recognition site; other site
76869008084	dimerization interface [polypeptide binding]; other site
76869008085	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
76869008086	putative binding surface; other site
76869008087	active site
76869008088	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869008089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869008090	active site
76869008091	phosphorylation site [posttranslational modification]
76869008092	intermolecular recognition site; other site
76869008093	dimerization interface [polypeptide binding]; other site
76869008094	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869008095	DNA binding residues [nucleotide binding]
76869008096	dimerization interface [polypeptide binding]; other site
76869008097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
76869008098	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
76869008099	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
76869008100	active site
76869008101	SAM binding site [chemical binding]; other site
76869008102	homodimer interface [polypeptide binding]; other site
76869008103	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
76869008104	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
76869008105	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
76869008106	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
76869008107	active site
76869008108	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
76869008109	dimer interface [polypeptide binding]; other site
76869008110	non-prolyl cis peptide bond; other site
76869008111	insertion regions; other site
76869008112	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
76869008113	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869008114	active site
76869008115	non-prolyl cis peptide bond; other site
76869008116	aldolase II superfamily protein; Provisional; Region: PRK07044
76869008117	active site
76869008118	intersubunit interface [polypeptide binding]; other site
76869008119	Zn2+ binding site [ion binding]; other site
76869008120	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180
76869008121	putative ligand binding site [chemical binding]; other site
76869008122	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
76869008123	putative NAD binding site [chemical binding]; other site
76869008124	catalytic site [active]
76869008125	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869008126	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
76869008127	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
76869008128	active site
76869008129	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869008130	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008131	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869008132	dimerization interface [polypeptide binding]; other site
76869008133	putative acetyltransferase; Provisional; Region: PRK03624
76869008134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869008135	Coenzyme A binding pocket [chemical binding]; other site
76869008136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869008137	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869008138	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869008139	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869008140	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
76869008141	metal binding triad; other site
76869008142	Pirin-related protein [General function prediction only]; Region: COG1741
76869008143	Pirin; Region: Pirin; pfam02678
76869008144	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
76869008145	AlkA N-terminal domain; Region: AlkA_N; pfam06029
76869008146	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
76869008147	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
76869008148	minor groove reading motif; other site
76869008149	helix-hairpin-helix signature motif; other site
76869008150	substrate binding pocket [chemical binding]; other site
76869008151	active site
76869008152	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
76869008153	Yip1 domain; Region: Yip1; cl17815
76869008154	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
76869008155	major curlin subunit; Provisional; Region: csgA; PRK10051
76869008156	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
76869008157	Curlin associated repeat; Region: Curlin_rpt; pfam07012
76869008158	Curlin associated repeat; Region: Curlin_rpt; pfam07012
76869008159	Curlin associated repeat; Region: Curlin_rpt; pfam07012
76869008160	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
76869008161	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
76869008162	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
76869008163	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
76869008164	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
76869008165	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
76869008166	active site
76869008167	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
76869008168	catalytic core [active]
76869008169	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
76869008170	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
76869008171	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869008172	Cytochrome c; Region: Cytochrom_C; pfam00034
76869008173	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869008174	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869008175	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869008176	Transcriptional regulators [Transcription]; Region: PurR; COG1609
76869008177	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
76869008178	DNA binding site [nucleotide binding]
76869008179	domain linker motif; other site
76869008180	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
76869008181	putative dimerization interface [polypeptide binding]; other site
76869008182	putative ligand binding site [chemical binding]; other site
76869008183	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
76869008184	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
76869008185	substrate binding site [chemical binding]; other site
76869008186	ATP binding site [chemical binding]; other site
76869008187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008188	D-galactonate transporter; Region: 2A0114; TIGR00893
76869008189	putative substrate translocation pore; other site
76869008190	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
76869008191	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
76869008192	dimerization interface [polypeptide binding]; other site
76869008193	ligand binding site [chemical binding]; other site
76869008194	NADP binding site [chemical binding]; other site
76869008195	catalytic site [active]
76869008196	DNA-specific endonuclease I; Provisional; Region: PRK15137
76869008197	Endonuclease I; Region: Endonuclease_1; pfam04231
76869008198	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
76869008199	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869008200	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869008201	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869008202	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869008203	Surface antigen; Region: Bac_surface_Ag; pfam01103
76869008204	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869008205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869008206	active site
76869008207	phosphorylation site [posttranslational modification]
76869008208	intermolecular recognition site; other site
76869008209	dimerization interface [polypeptide binding]; other site
76869008210	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869008211	DNA binding site [nucleotide binding]
76869008212	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869008213	HAMP domain; Region: HAMP; pfam00672
76869008214	dimerization interface [polypeptide binding]; other site
76869008215	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869008216	dimer interface [polypeptide binding]; other site
76869008217	phosphorylation site [posttranslational modification]
76869008218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869008219	ATP binding site [chemical binding]; other site
76869008220	Mg2+ binding site [ion binding]; other site
76869008221	G-X-G motif; other site
76869008222	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869008223	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
76869008224	dimerization interface [polypeptide binding]; other site
76869008225	putative DNA binding site [nucleotide binding]; other site
76869008226	putative Zn2+ binding site [ion binding]; other site
76869008227	AsnC family; Region: AsnC_trans_reg; pfam01037
76869008228	allantoate amidohydrolase; Reviewed; Region: PRK12890
76869008229	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
76869008230	active site
76869008231	metal binding site [ion binding]; metal-binding site
76869008232	dimer interface [polypeptide binding]; other site
76869008233	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
76869008234	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
76869008235	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869008236	catalytic residue [active]
76869008237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008238	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869008239	putative substrate translocation pore; other site
76869008240	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869008241	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869008242	putative DNA binding site [nucleotide binding]; other site
76869008243	AsnC family; Region: AsnC_trans_reg; pfam01037
76869008244	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869008245	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869008246	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869008247	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869008248	substrate binding pocket [chemical binding]; other site
76869008249	membrane-bound complex binding site; other site
76869008250	hinge residues; other site
76869008251	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869008252	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869008253	Walker A/P-loop; other site
76869008254	ATP binding site [chemical binding]; other site
76869008255	Q-loop/lid; other site
76869008256	ABC transporter signature motif; other site
76869008257	Walker B; other site
76869008258	D-loop; other site
76869008259	H-loop/switch region; other site
76869008260	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869008261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008262	dimer interface [polypeptide binding]; other site
76869008263	conserved gate region; other site
76869008264	putative PBP binding loops; other site
76869008265	ABC-ATPase subunit interface; other site
76869008266	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
76869008267	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869008268	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008269	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869008270	dimerization interface [polypeptide binding]; other site
76869008271	acetolactate synthase; Reviewed; Region: PRK08322
76869008272	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869008273	PYR/PP interface [polypeptide binding]; other site
76869008274	dimer interface [polypeptide binding]; other site
76869008275	TPP binding site [chemical binding]; other site
76869008276	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869008277	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
76869008278	TPP-binding site [chemical binding]; other site
76869008279	dimer interface [polypeptide binding]; other site
76869008280	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
76869008281	GAF domain; Region: GAF; pfam01590
76869008282	Phytochrome region; Region: PHY; pfam00360
76869008283	HWE histidine kinase; Region: HWE_HK; pfam07536
76869008284	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869008285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869008286	active site
76869008287	phosphorylation site [posttranslational modification]
76869008288	intermolecular recognition site; other site
76869008289	dimerization interface [polypeptide binding]; other site
76869008290	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869008291	Predicted amidohydrolase [General function prediction only]; Region: COG0388
76869008292	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
76869008293	putative active site [active]
76869008294	catalytic triad [active]
76869008295	putative dimer interface [polypeptide binding]; other site
76869008296	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869008297	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869008298	DNA binding residues [nucleotide binding]
76869008299	dimerization interface [polypeptide binding]; other site
76869008300	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869008301	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869008302	DNA binding residues [nucleotide binding]
76869008303	dimerization interface [polypeptide binding]; other site
76869008304	amino acid transporter; Region: 2A0306; TIGR00909
76869008305	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
76869008306	homodimer interface [polypeptide binding]; other site
76869008307	homotetramer interface [polypeptide binding]; other site
76869008308	active site pocket [active]
76869008309	cleavage site
76869008310	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
76869008311	TMP-binding site; other site
76869008312	ATP-binding site [chemical binding]; other site
76869008313	SnoaL-like domain; Region: SnoaL_3; pfam13474
76869008314	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
76869008315	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
76869008316	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
76869008317	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869008318	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869008319	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869008320	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869008321	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869008322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869008323	active site
76869008324	phosphorylation site [posttranslational modification]
76869008325	intermolecular recognition site; other site
76869008326	dimerization interface [polypeptide binding]; other site
76869008327	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869008328	DNA binding site [nucleotide binding]
76869008329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869008330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869008331	dimer interface [polypeptide binding]; other site
76869008332	phosphorylation site [posttranslational modification]
76869008333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869008334	ATP binding site [chemical binding]; other site
76869008335	Mg2+ binding site [ion binding]; other site
76869008336	G-X-G motif; other site
76869008337	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869008338	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
76869008339	putative DNA binding site [nucleotide binding]; other site
76869008340	putative Zn2+ binding site [ion binding]; other site
76869008341	AsnC family; Region: AsnC_trans_reg; pfam01037
76869008342	hypothetical protein; Provisional; Region: PRK06148
76869008343	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
76869008344	active site
76869008345	ATP binding site [chemical binding]; other site
76869008346	substrate binding site [chemical binding]; other site
76869008347	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869008348	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869008349	inhibitor-cofactor binding pocket; inhibition site
76869008350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869008351	catalytic residue [active]
76869008352	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869008353	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
76869008354	AsnC family; Region: AsnC_trans_reg; pfam01037
76869008355	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869008356	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869008357	substrate binding pocket [chemical binding]; other site
76869008358	membrane-bound complex binding site; other site
76869008359	hinge residues; other site
76869008360	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869008361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008362	dimer interface [polypeptide binding]; other site
76869008363	conserved gate region; other site
76869008364	putative PBP binding loops; other site
76869008365	ABC-ATPase subunit interface; other site
76869008366	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869008367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008368	dimer interface [polypeptide binding]; other site
76869008369	conserved gate region; other site
76869008370	putative PBP binding loops; other site
76869008371	ABC-ATPase subunit interface; other site
76869008372	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869008373	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869008374	Walker A/P-loop; other site
76869008375	ATP binding site [chemical binding]; other site
76869008376	Q-loop/lid; other site
76869008377	ABC transporter signature motif; other site
76869008378	Walker B; other site
76869008379	D-loop; other site
76869008380	H-loop/switch region; other site
76869008381	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
76869008382	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
76869008383	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
76869008384	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
76869008385	NADP binding site [chemical binding]; other site
76869008386	homopentamer interface [polypeptide binding]; other site
76869008387	substrate binding site [chemical binding]; other site
76869008388	active site
76869008389	PaaX-like protein; Region: PaaX; pfam07848
76869008390	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
76869008391	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
76869008392	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
76869008393	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
76869008394	putative trimer interface [polypeptide binding]; other site
76869008395	putative metal binding site [ion binding]; other site
76869008396	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
76869008397	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869008398	substrate binding site [chemical binding]; other site
76869008399	oxyanion hole (OAH) forming residues; other site
76869008400	trimer interface [polypeptide binding]; other site
76869008401	enoyl-CoA hydratase; Provisional; Region: PRK08140
76869008402	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869008403	substrate binding site [chemical binding]; other site
76869008404	oxyanion hole (OAH) forming residues; other site
76869008405	trimer interface [polypeptide binding]; other site
76869008406	3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279
76869008407	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
76869008408	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
76869008409	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
76869008410	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
76869008411	CoenzymeA binding site [chemical binding]; other site
76869008412	subunit interaction site [polypeptide binding]; other site
76869008413	PHB binding site; other site
76869008414	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
76869008415	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869008416	dimer interface [polypeptide binding]; other site
76869008417	active site
76869008418	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
76869008419	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
76869008420	active site
76869008421	AMP binding site [chemical binding]; other site
76869008422	homodimer interface [polypeptide binding]; other site
76869008423	acyl-activating enzyme (AAE) consensus motif; other site
76869008424	CoA binding site [chemical binding]; other site
76869008425	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
76869008426	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
76869008427	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
76869008428	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
76869008429	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
76869008430	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
76869008431	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
76869008432	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
76869008433	FAD binding pocket [chemical binding]; other site
76869008434	FAD binding motif [chemical binding]; other site
76869008435	phosphate binding motif [ion binding]; other site
76869008436	beta-alpha-beta structure motif; other site
76869008437	NAD(p) ribose binding residues [chemical binding]; other site
76869008438	NAD binding pocket [chemical binding]; other site
76869008439	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
76869008440	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869008441	catalytic loop [active]
76869008442	iron binding site [ion binding]; other site
76869008443	Protein of unknown function, DUF485; Region: DUF485; pfam04341
76869008444	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
76869008445	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
76869008446	Na binding site [ion binding]; other site
76869008447	outer membrane porin, OprD family; Region: OprD; pfam03573
76869008448	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
76869008449	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
76869008450	substrate binding site [chemical binding]; other site
76869008451	dimer interface [polypeptide binding]; other site
76869008452	NADP binding site [chemical binding]; other site
76869008453	catalytic residues [active]
76869008454	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
76869008455	substrate binding site [chemical binding]; other site
76869008456	General stress protein [General function prediction only]; Region: GsiB; COG3729
76869008457	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
76869008458	active site
76869008459	Low affinity iron permease; Region: Iron_permease; pfam04120
76869008460	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
76869008461	putative catalytic site [active]
76869008462	putative metal binding site [ion binding]; other site
76869008463	putative phosphate binding site [ion binding]; other site
76869008464	cardiolipin synthase 2; Provisional; Region: PRK11263
76869008465	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
76869008466	putative active site [active]
76869008467	catalytic site [active]
76869008468	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
76869008469	putative active site [active]
76869008470	catalytic site [active]
76869008471	Predicted integral membrane protein [Function unknown]; Region: COG0392
76869008472	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
76869008473	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
76869008474	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
76869008475	active site
76869008476	DNA binding site [nucleotide binding]
76869008477	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
76869008478	DNA binding site [nucleotide binding]
76869008479	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
76869008480	nucleotide binding site [chemical binding]; other site
76869008481	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869008482	active site
76869008483	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869008484	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
76869008485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869008486	S-adenosylmethionine binding site [chemical binding]; other site
76869008487	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
76869008488	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
76869008489	active site
76869008490	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
76869008491	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
76869008492	putative DNA binding site [nucleotide binding]; other site
76869008493	putative homodimer interface [polypeptide binding]; other site
76869008494	nucleosidase; Provisional; Region: PRK05634
76869008495	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
76869008496	TLC ATP/ADP transporter; Region: TLC; cl03940
76869008497	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869008498	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869008499	active site
76869008500	catalytic tetrad [active]
76869008501	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
76869008502	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
76869008503	Sodium Bile acid symporter family; Region: SBF; pfam01758
76869008504	beta-carotene hydroxylase; Region: PLN02601
76869008505	MgtC family; Region: MgtC; pfam02308
76869008506	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
76869008507	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
76869008508	cytosine deaminase; Provisional; Region: PRK09230
76869008509	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
76869008510	active site
76869008511	cytosine permease; Provisional; Region: codB; PRK11017
76869008512	Na binding site [ion binding]; other site
76869008513	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
76869008514	intersubunit interface [polypeptide binding]; other site
76869008515	active site
76869008516	Zn2+ binding site [ion binding]; other site
76869008517	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869008518	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869008519	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
76869008520	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869008521	N-terminal plug; other site
76869008522	ligand-binding site [chemical binding]; other site
76869008523	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
76869008524	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
76869008525	active site
76869008526	non-prolyl cis peptide bond; other site
76869008527	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
76869008528	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
76869008529	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
76869008530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869008531	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
76869008532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008533	dimer interface [polypeptide binding]; other site
76869008534	conserved gate region; other site
76869008535	ABC-ATPase subunit interface; other site
76869008536	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
76869008537	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869008538	Walker A/P-loop; other site
76869008539	ATP binding site [chemical binding]; other site
76869008540	Q-loop/lid; other site
76869008541	ABC transporter signature motif; other site
76869008542	Walker B; other site
76869008543	D-loop; other site
76869008544	H-loop/switch region; other site
76869008545	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
76869008546	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869008547	Walker A/P-loop; other site
76869008548	ATP binding site [chemical binding]; other site
76869008549	Q-loop/lid; other site
76869008550	ABC transporter signature motif; other site
76869008551	Walker B; other site
76869008552	D-loop; other site
76869008553	H-loop/switch region; other site
76869008554	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
76869008555	Putative transcription activator [Transcription]; Region: TenA; COG0819
76869008556	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
76869008557	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
76869008558	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
76869008559	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
76869008560	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
76869008561	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
76869008562	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
76869008563	Cu(I) binding site [ion binding]; other site
76869008564	Cytochrome c; Region: Cytochrom_C; pfam00034
76869008565	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869008566	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869008567	metal binding site [ion binding]; metal-binding site
76869008568	active site
76869008569	I-site; other site
76869008570	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869008571	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
76869008572	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869008573	substrate binding pocket [chemical binding]; other site
76869008574	membrane-bound complex binding site; other site
76869008575	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
76869008576	DNA binding site [nucleotide binding]
76869008577	dimer interface [polypeptide binding]; other site
76869008578	active site
76869008579	Int/Topo IB signature motif; other site
76869008580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869008581	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
76869008582	NAD(P) binding site [chemical binding]; other site
76869008583	active site
76869008584	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
76869008585	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
76869008586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008587	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
76869008588	dimerization interface [polypeptide binding]; other site
76869008589	substrate binding pocket [chemical binding]; other site
76869008590	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
76869008591	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
76869008592	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
76869008593	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
76869008594	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
76869008595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008596	putative substrate translocation pore; other site
76869008597	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
76869008598	[2Fe-2S] cluster binding site [ion binding]; other site
76869008599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
76869008600	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869008601	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869008602	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869008603	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869008604	active site
76869008605	catalytic tetrad [active]
76869008606	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
76869008607	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
76869008608	FMN binding site [chemical binding]; other site
76869008609	active site
76869008610	substrate binding site [chemical binding]; other site
76869008611	catalytic residue [active]
76869008612	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
76869008613	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869008614	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
76869008615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008616	LysR family transcriptional regulator; Provisional; Region: PRK14997
76869008617	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869008618	putative effector binding pocket; other site
76869008619	dimerization interface [polypeptide binding]; other site
76869008620	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
76869008621	outer membrane porin, OprD family; Region: OprD; pfam03573
76869008622	Benzoate membrane transport protein; Region: BenE; pfam03594
76869008623	benzoate transporter; Region: benE; TIGR00843
76869008624	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
76869008625	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
76869008626	active site
76869008627	benzoate transport; Region: 2A0115; TIGR00895
76869008628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008629	putative substrate translocation pore; other site
76869008630	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
76869008631	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
76869008632	putative NAD(P) binding site [chemical binding]; other site
76869008633	active site
76869008634	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
76869008635	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869008636	catalytic loop [active]
76869008637	iron binding site [ion binding]; other site
76869008638	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
76869008639	FAD binding pocket [chemical binding]; other site
76869008640	FAD binding motif [chemical binding]; other site
76869008641	phosphate binding motif [ion binding]; other site
76869008642	beta-alpha-beta structure motif; other site
76869008643	NAD binding pocket [chemical binding]; other site
76869008644	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
76869008645	inter-subunit interface; other site
76869008646	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
76869008647	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
76869008648	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
76869008649	putative alpha subunit interface [polypeptide binding]; other site
76869008650	putative active site [active]
76869008651	putative substrate binding site [chemical binding]; other site
76869008652	Fe binding site [ion binding]; other site
76869008653	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869008654	Helix-turn-helix domain; Region: HTH_18; pfam12833
76869008655	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869008656	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869008657	conserved cys residue [active]
76869008658	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869008659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869008660	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
76869008661	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
76869008662	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869008663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008664	dimer interface [polypeptide binding]; other site
76869008665	conserved gate region; other site
76869008666	putative PBP binding loops; other site
76869008667	ABC-ATPase subunit interface; other site
76869008668	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
76869008669	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
76869008670	Walker A/P-loop; other site
76869008671	ATP binding site [chemical binding]; other site
76869008672	Q-loop/lid; other site
76869008673	ABC transporter signature motif; other site
76869008674	Walker B; other site
76869008675	D-loop; other site
76869008676	H-loop/switch region; other site
76869008677	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
76869008678	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
76869008679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869008681	dimerization interface [polypeptide binding]; other site
76869008682	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869008683	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
76869008684	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
76869008685	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
76869008686	active site
76869008687	hypothetical protein; Provisional; Region: PRK11469
76869008688	Domain of unknown function DUF; Region: DUF204; pfam02659
76869008689	Domain of unknown function DUF; Region: DUF204; pfam02659
76869008690	universal stress protein UspE; Provisional; Region: PRK11175
76869008691	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869008692	Ligand Binding Site [chemical binding]; other site
76869008693	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869008694	Ligand Binding Site [chemical binding]; other site
76869008695	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
76869008696	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
76869008697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869008698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008699	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
76869008700	putative dimerization interface [polypeptide binding]; other site
76869008701	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
76869008702	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
76869008703	NAD(P) binding site [chemical binding]; other site
76869008704	catalytic residues [active]
76869008705	AAA domain; Region: AAA_30; pfam13604
76869008706	Helix-turn-helix domain; Region: HTH_18; pfam12833
76869008707	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869008708	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869008709	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869008710	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869008711	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869008712	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869008713	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
76869008714	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
76869008715	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
76869008716	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
76869008717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008718	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869008719	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
76869008720	dimerization interface [polypeptide binding]; other site
76869008721	substrate binding pocket [chemical binding]; other site
76869008722	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
76869008723	Bacterial sugar transferase; Region: Bac_transf; pfam02397
76869008724	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
76869008725	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
76869008726	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
76869008727	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
76869008728	DXD motif; other site
76869008729	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
76869008730	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
76869008731	putative ADP-binding pocket [chemical binding]; other site
76869008732	Protein of unknown function (DUF535); Region: DUF535; pfam04393
76869008733	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
76869008734	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
76869008735	active site
76869008736	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
76869008737	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
76869008738	trimer interface [polypeptide binding]; other site
76869008739	active site
76869008740	substrate binding site [chemical binding]; other site
76869008741	CoA binding site [chemical binding]; other site
76869008742	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
76869008743	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
76869008744	Probable Catalytic site; other site
76869008745	metal-binding site
76869008746	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
76869008747	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
76869008748	trimer interface [polypeptide binding]; other site
76869008749	active site
76869008750	substrate binding site [chemical binding]; other site
76869008751	CoA binding site [chemical binding]; other site
76869008752	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
76869008753	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869008754	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
76869008755	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
76869008756	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
76869008757	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
76869008758	NAD binding site [chemical binding]; other site
76869008759	homodimer interface [polypeptide binding]; other site
76869008760	active site
76869008761	substrate binding site [chemical binding]; other site
76869008762	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
76869008763	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
76869008764	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
76869008765	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
76869008766	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
76869008767	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869008768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869008769	non-specific DNA binding site [nucleotide binding]; other site
76869008770	salt bridge; other site
76869008771	sequence-specific DNA binding site [nucleotide binding]; other site
76869008772	Cupin domain; Region: Cupin_2; pfam07883
76869008773	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
76869008774	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
76869008775	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
76869008776	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869008777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008778	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
76869008779	putative dimerization interface [polypeptide binding]; other site
76869008780	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869008781	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869008782	active site
76869008783	catalytic tetrad [active]
76869008784	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
76869008785	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
76869008786	putative active site [active]
76869008787	putative PHP Thumb interface [polypeptide binding]; other site
76869008788	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
76869008789	generic binding surface I; other site
76869008790	generic binding surface II; other site
76869008791	DNA Polymerase Y-family; Region: PolY_like; cd03468
76869008792	active site
76869008793	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
76869008794	DNA binding site [nucleotide binding]
76869008795	Cell division inhibitor SulA; Region: SulA; cl01880
76869008796	LexA repressor; Provisional; Region: PRK12423
76869008797	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
76869008798	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869008799	Catalytic site [active]
76869008800	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869008801	motif II; other site
76869008802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869008803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869008804	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
76869008805	putative dimerization interface [polypeptide binding]; other site
76869008806	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869008807	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869008808	N-terminal plug; other site
76869008809	ligand-binding site [chemical binding]; other site
76869008810	benzoate transport; Region: 2A0115; TIGR00895
76869008811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008812	putative substrate translocation pore; other site
76869008813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008814	NIPSNAP; Region: NIPSNAP; pfam07978
76869008815	putative succinate dehydrogenase; Reviewed; Region: PRK12842
76869008816	Predicted oxidoreductase [General function prediction only]; Region: COG3573
76869008817	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
76869008818	classical (c) SDRs; Region: SDR_c; cd05233
76869008819	NAD(P) binding site [chemical binding]; other site
76869008820	active site
76869008821	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
76869008822	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869008823	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
76869008824	Transcriptional regulator [Transcription]; Region: IclR; COG1414
76869008825	amidase; Provisional; Region: PRK07486
76869008826	Amidase; Region: Amidase; cl11426
76869008827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008828	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869008829	putative substrate translocation pore; other site
76869008830	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
76869008831	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
76869008832	metal binding site [ion binding]; metal-binding site
76869008833	putative dimer interface [polypeptide binding]; other site
76869008834	PAAR motif; Region: PAAR_motif; pfam05488
76869008835	HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410
76869008836	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
76869008837	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
76869008838	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
76869008839	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
76869008840	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
76869008841	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
76869008842	virulence protein SpvB; Provisional; Region: PRK15244
76869008843	Protein of unknown function (DUF770); Region: DUF770; pfam05591
76869008844	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
76869008845	Protein of unknown function (DUF877); Region: DUF877; pfam05943
76869008846	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
76869008847	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
76869008848	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
76869008849	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
76869008850	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
76869008851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869008852	Walker A motif; other site
76869008853	ATP binding site [chemical binding]; other site
76869008854	Walker B motif; other site
76869008855	arginine finger; other site
76869008856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869008857	Walker A motif; other site
76869008858	ATP binding site [chemical binding]; other site
76869008859	Walker B motif; other site
76869008860	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
76869008861	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
76869008862	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
76869008863	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
76869008864	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
76869008865	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
76869008866	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
76869008867	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
76869008868	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
76869008869	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
76869008870	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
76869008871	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869008872	ligand binding site [chemical binding]; other site
76869008873	Protein of unknown function (DUF796); Region: DUF796; pfam05638
76869008874	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
76869008875	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
76869008876	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
76869008877	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
76869008878	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
76869008879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869008880	Walker A/P-loop; other site
76869008881	ATP binding site [chemical binding]; other site
76869008882	Q-loop/lid; other site
76869008883	ABC transporter signature motif; other site
76869008884	Walker B; other site
76869008885	D-loop; other site
76869008886	H-loop/switch region; other site
76869008887	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869008888	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869008889	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869008890	DNA binding residues [nucleotide binding]
76869008891	fec operon regulator FecR; Reviewed; Region: PRK09774
76869008892	FecR protein; Region: FecR; pfam04773
76869008893	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869008894	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869008895	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869008896	N-terminal plug; other site
76869008897	ligand-binding site [chemical binding]; other site
76869008898	Predicted permeases [General function prediction only]; Region: COG0679
76869008899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008900	putative substrate translocation pore; other site
76869008901	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869008902	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
76869008903	substrate binding site [chemical binding]; other site
76869008904	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
76869008905	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
76869008906	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
76869008907	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
76869008908	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
76869008909	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
76869008910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008911	dimer interface [polypeptide binding]; other site
76869008912	conserved gate region; other site
76869008913	putative PBP binding loops; other site
76869008914	ABC-ATPase subunit interface; other site
76869008915	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
76869008916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869008917	dimer interface [polypeptide binding]; other site
76869008918	conserved gate region; other site
76869008919	putative PBP binding loops; other site
76869008920	ABC-ATPase subunit interface; other site
76869008921	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
76869008922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869008923	Walker B motif; other site
76869008924	arginine finger; other site
76869008925	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869008926	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
76869008927	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
76869008928	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
76869008929	NAD binding site [chemical binding]; other site
76869008930	homotetramer interface [polypeptide binding]; other site
76869008931	homodimer interface [polypeptide binding]; other site
76869008932	substrate binding site [chemical binding]; other site
76869008933	active site
76869008934	ecotin; Provisional; Region: PRK03719
76869008935	secondary substrate binding site; other site
76869008936	primary substrate binding site; other site
76869008937	inhibition loop; other site
76869008938	dimerization interface [polypeptide binding]; other site
76869008939	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
76869008940	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
76869008941	acyl-activating enzyme (AAE) consensus motif; other site
76869008942	putative AMP binding site [chemical binding]; other site
76869008943	putative active site [active]
76869008944	putative CoA binding site [chemical binding]; other site
76869008945	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
76869008946	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
76869008947	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
76869008948	Autotransporter beta-domain; Region: Autotransporter; smart00869
76869008949	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869008950	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869008951	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869008952	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869008953	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869008954	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869008955	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
76869008956	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
76869008957	active site
76869008958	metal binding site [ion binding]; metal-binding site
76869008959	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
76869008960	Predicted amidohydrolase [General function prediction only]; Region: COG0388
76869008961	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
76869008962	active site
76869008963	catalytic triad [active]
76869008964	dimer interface [polypeptide binding]; other site
76869008965	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
76869008966	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
76869008967	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
76869008968	DNA binding site [nucleotide binding]
76869008969	active site
76869008970	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
76869008971	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
76869008972	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
76869008973	dimer interface [polypeptide binding]; other site
76869008974	acyl-activating enzyme (AAE) consensus motif; other site
76869008975	putative active site [active]
76869008976	AMP binding site [chemical binding]; other site
76869008977	putative CoA binding site [chemical binding]; other site
76869008978	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
76869008979	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
76869008980	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869008981	active site
76869008982	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
76869008983	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
76869008984	Protein export membrane protein; Region: SecD_SecF; cl14618
76869008985	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
76869008986	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
76869008987	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
76869008988	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
76869008989	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869008990	SurA N-terminal domain; Region: SurA_N; pfam09312
76869008991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869008992	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
76869008993	iron-sulfur cluster [ion binding]; other site
76869008994	[2Fe-2S] cluster binding site [ion binding]; other site
76869008995	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
76869008996	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
76869008997	catalytic residues [active]
76869008998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869008999	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869009000	putative substrate translocation pore; other site
76869009001	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
76869009002	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
76869009003	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
76869009004	substrate binding pocket [chemical binding]; other site
76869009005	active site
76869009006	iron coordination sites [ion binding]; other site
76869009007	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
76869009008	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
76869009009	NADP binding site [chemical binding]; other site
76869009010	dimer interface [polypeptide binding]; other site
76869009011	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
76869009012	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
76869009013	DNA binding residues [nucleotide binding]
76869009014	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
76869009015	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
76869009016	putative active site [active]
76869009017	putative FMN binding site [chemical binding]; other site
76869009018	putative substrate binding site [chemical binding]; other site
76869009019	putative catalytic residue [active]
76869009020	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
76869009021	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
76869009022	trimer interface [polypeptide binding]; other site
76869009023	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
76869009024	active site
76869009025	substrate binding site [chemical binding]; other site
76869009026	CoA binding site [chemical binding]; other site
76869009027	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
76869009028	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
76869009029	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869009030	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
76869009031	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869009032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869009033	Walker A/P-loop; other site
76869009034	ATP binding site [chemical binding]; other site
76869009035	ABC transporter signature motif; other site
76869009036	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869009037	Walker B; other site
76869009038	ABC transporter; Region: ABC_tran_2; pfam12848
76869009039	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
76869009040	major facilitator superfamily transporter; Provisional; Region: PRK05122
76869009041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009042	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
76869009043	putative S-transferase; Provisional; Region: PRK11752
76869009044	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
76869009045	C-terminal domain interface [polypeptide binding]; other site
76869009046	GSH binding site (G-site) [chemical binding]; other site
76869009047	dimer interface [polypeptide binding]; other site
76869009048	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
76869009049	dimer interface [polypeptide binding]; other site
76869009050	N-terminal domain interface [polypeptide binding]; other site
76869009051	active site
76869009052	amidase; Validated; Region: PRK06565
76869009053	Amidase; Region: Amidase; cl11426
76869009054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
76869009055	YheO-like PAS domain; Region: PAS_6; pfam08348
76869009056	HTH domain; Region: HTH_22; pfam13309
76869009057	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
76869009058	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869009059	catalytic residue [active]
76869009060	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
76869009061	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
76869009062	dimer interface [polypeptide binding]; other site
76869009063	active site
76869009064	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869009065	catalytic residues [active]
76869009066	substrate binding site [chemical binding]; other site
76869009067	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
76869009068	Methyltransferase domain; Region: Methyltransf_31; pfam13847
76869009069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869009070	S-adenosylmethionine binding site [chemical binding]; other site
76869009071	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
76869009072	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
76869009073	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
76869009074	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
76869009075	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
76869009076	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
76869009077	putative NAD(P) binding site [chemical binding]; other site
76869009078	active site
76869009079	putative substrate binding site [chemical binding]; other site
76869009080	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
76869009081	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
76869009082	Ligand binding site; other site
76869009083	Putative Catalytic site; other site
76869009084	DXD motif; other site
76869009085	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
76869009086	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
76869009087	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
76869009088	malate:quinone oxidoreductase; Validated; Region: PRK05257
76869009089	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
76869009090	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
76869009091	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869009092	FeS/SAM binding site; other site
76869009093	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
76869009094	PAAR motif; Region: PAAR_motif; pfam05488
76869009095	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
76869009096	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
76869009097	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
76869009098	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
76869009099	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
76869009100	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
76869009101	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
76869009102	hypothetical protein; Provisional; Region: PRK12569
76869009103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009105	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
76869009106	putative substrate binding pocket [chemical binding]; other site
76869009107	dimerization interface [polypeptide binding]; other site
76869009108	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
76869009109	Autotransporter beta-domain; Region: Autotransporter; smart00869
76869009110	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
76869009111	Lumazine binding domain; Region: Lum_binding; pfam00677
76869009112	Lumazine binding domain; Region: Lum_binding; pfam00677
76869009113	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
76869009114	proline/glycine betaine transporter; Provisional; Region: PRK10642
76869009115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009116	putative substrate translocation pore; other site
76869009117	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
76869009118	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
76869009119	dimer interface [polypeptide binding]; other site
76869009120	active site
76869009121	Schiff base residues; other site
76869009122	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
76869009123	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
76869009124	ATP binding site [chemical binding]; other site
76869009125	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
76869009126	Spore germination protein; Region: Spore_permease; cl17796
76869009127	Predicted dehydrogenase [General function prediction only]; Region: COG0579
76869009128	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869009129	carbon starvation induced protein; Validated; Region: PRK02963
76869009130	substrate binding pocket [chemical binding]; other site
76869009131	active site
76869009132	iron coordination sites [ion binding]; other site
76869009133	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
76869009134	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869009135	DNA-binding site [nucleotide binding]; DNA binding site
76869009136	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869009137	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869009138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009139	active site
76869009140	phosphorylation site [posttranslational modification]
76869009141	intermolecular recognition site; other site
76869009142	dimerization interface [polypeptide binding]; other site
76869009143	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869009144	DNA binding site [nucleotide binding]
76869009145	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869009146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869009147	dimerization interface [polypeptide binding]; other site
76869009148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869009149	dimer interface [polypeptide binding]; other site
76869009150	phosphorylation site [posttranslational modification]
76869009151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009152	ATP binding site [chemical binding]; other site
76869009153	Mg2+ binding site [ion binding]; other site
76869009154	G-X-G motif; other site
76869009155	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
76869009156	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
76869009157	active site
76869009158	HIGH motif; other site
76869009159	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
76869009160	KMSKS motif; other site
76869009161	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
76869009162	tRNA binding surface [nucleotide binding]; other site
76869009163	anticodon binding site; other site
76869009164	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
76869009165	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
76869009166	active site
76869009167	HIGH motif; other site
76869009168	nucleotide binding site [chemical binding]; other site
76869009169	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
76869009170	KMSKS motif; other site
76869009171	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
76869009172	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
76869009173	substrate binding site [chemical binding]; other site
76869009174	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
76869009175	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
76869009176	putative active site [active]
76869009177	putative metal binding site [ion binding]; other site
76869009178	Penicillin amidase; Region: Penicil_amidase; pfam01804
76869009179	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
76869009180	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
76869009181	active site
76869009182	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
76869009183	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
76869009184	Mor transcription activator family; Region: Mor; cl02360
76869009185	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
76869009186	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
76869009187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
76869009188	Family of unknown function (DUF490); Region: DUF490; pfam04357
76869009189	Family of unknown function (DUF490); Region: DUF490; pfam04357
76869009190	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
76869009191	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869009192	Surface antigen; Region: Bac_surface_Ag; pfam01103
76869009193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
76869009194	Coenzyme A binding pocket [chemical binding]; other site
76869009195	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
76869009196	putative catalytic site [active]
76869009197	putative phosphate binding site [ion binding]; other site
76869009198	active site
76869009199	metal binding site A [ion binding]; metal-binding site
76869009200	DNA binding site [nucleotide binding]
76869009201	putative AP binding site [nucleotide binding]; other site
76869009202	putative metal binding site B [ion binding]; other site
76869009203	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
76869009204	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
76869009205	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869009206	DNA binding residues [nucleotide binding]
76869009207	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
76869009208	putative heme binding pocket [chemical binding]; other site
76869009209	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
76869009210	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869009211	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
76869009212	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869009213	non-specific DNA binding site [nucleotide binding]; other site
76869009214	salt bridge; other site
76869009215	sequence-specific DNA binding site [nucleotide binding]; other site
76869009216	Cupin domain; Region: Cupin_2; pfam07883
76869009217	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
76869009218	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
76869009219	putative catalytic residue [active]
76869009220	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
76869009221	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
76869009222	putative NAD(P) binding site [chemical binding]; other site
76869009223	active site
76869009224	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869009225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869009226	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
76869009227	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
76869009228	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
76869009229	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
76869009230	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
76869009231	Uncharacterized conserved protein [Function unknown]; Region: COG0393
76869009232	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
76869009233	EamA-like transporter family; Region: EamA; pfam00892
76869009234	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
76869009235	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869009236	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
76869009237	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
76869009238	putative active site [active]
76869009239	putative FMN binding site [chemical binding]; other site
76869009240	putative substrate binding site [chemical binding]; other site
76869009241	putative catalytic residue [active]
76869009242	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
76869009243	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869009244	non-specific DNA binding site [nucleotide binding]; other site
76869009245	salt bridge; other site
76869009246	sequence-specific DNA binding site [nucleotide binding]; other site
76869009247	Cupin domain; Region: Cupin_2; pfam07883
76869009248	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
76869009249	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869009250	azoreductase; Reviewed; Region: PRK00170
76869009251	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869009252	LysR family transcriptional regulator; Provisional; Region: PRK14997
76869009253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009254	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869009255	dimerization interface [polypeptide binding]; other site
76869009256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
76869009257	Predicted membrane protein [Function unknown]; Region: COG3326
76869009258	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
76869009259	Cache domain; Region: Cache_2; pfam08269
76869009260	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
76869009261	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869009262	dimerization interface [polypeptide binding]; other site
76869009263	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869009264	dimer interface [polypeptide binding]; other site
76869009265	putative CheW interface [polypeptide binding]; other site
76869009266	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
76869009267	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
76869009268	AAA domain; Region: AAA_28; pfam13521
76869009269	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
76869009270	putative active site [active]
76869009271	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
76869009272	Sulfatase; Region: Sulfatase; pfam00884
76869009273	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
76869009274	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
76869009275	G1 box; other site
76869009276	GTP/Mg2+ binding site [chemical binding]; other site
76869009277	Switch I region; other site
76869009278	Switch II region; other site
76869009279	G4 box; other site
76869009280	G5 box; other site
76869009281	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
76869009282	UreF; Region: UreF; pfam01730
76869009283	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
76869009284	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
76869009285	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
76869009286	dimer interface [polypeptide binding]; other site
76869009287	catalytic residues [active]
76869009288	urease subunit alpha; Reviewed; Region: ureC; PRK13207
76869009289	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
76869009290	subunit interactions [polypeptide binding]; other site
76869009291	active site
76869009292	flap region; other site
76869009293	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
76869009294	gamma-beta subunit interface [polypeptide binding]; other site
76869009295	alpha-beta subunit interface [polypeptide binding]; other site
76869009296	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
76869009297	alpha-gamma subunit interface [polypeptide binding]; other site
76869009298	beta-gamma subunit interface [polypeptide binding]; other site
76869009299	UreD urease accessory protein; Region: UreD; pfam01774
76869009300	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
76869009301	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869009302	active site
76869009303	DNA binding site [nucleotide binding]
76869009304	Int/Topo IB signature motif; other site
76869009305	NnrS protein; Region: NnrS; pfam05940
76869009306	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
76869009307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
76869009308	DEAD_2; Region: DEAD_2; pfam06733
76869009309	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
76869009310	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
76869009311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009312	D-galactonate transporter; Region: 2A0114; TIGR00893
76869009313	putative substrate translocation pore; other site
76869009314	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
76869009315	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
76869009316	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
76869009317	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
76869009318	galactarate dehydratase; Region: galactar-dH20; TIGR03248
76869009319	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
76869009320	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009322	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
76869009323	putative dimerization interface [polypeptide binding]; other site
76869009324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009326	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
76869009327	putative dimerization interface [polypeptide binding]; other site
76869009328	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
76869009329	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
76869009330	putative active site pocket [active]
76869009331	metal binding site [ion binding]; metal-binding site
76869009332	D-galactonate transporter; Region: 2A0114; TIGR00893
76869009333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009334	putative substrate translocation pore; other site
76869009335	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869009336	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
76869009337	DNA-binding site [nucleotide binding]; DNA binding site
76869009338	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
76869009339	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869009340	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
76869009341	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
76869009342	putative NAD(P) binding site [chemical binding]; other site
76869009343	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009345	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
76869009346	putative substrate binding pocket [chemical binding]; other site
76869009347	putative dimerization interface [polypeptide binding]; other site
76869009348	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
76869009349	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
76869009350	active site
76869009351	Int/Topo IB signature motif; other site
76869009352	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
76869009353	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869009354	Coenzyme A binding pocket [chemical binding]; other site
76869009355	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
76869009356	Chromate transporter; Region: Chromate_transp; cl17781
76869009357	CHASE4 domain; Region: CHASE4; pfam05228
76869009358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869009359	PAS domain; Region: PAS_9; pfam13426
76869009360	putative active site [active]
76869009361	heme pocket [chemical binding]; other site
76869009362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869009363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869009364	metal binding site [ion binding]; metal-binding site
76869009365	active site
76869009366	I-site; other site
76869009367	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869009368	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
76869009369	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
76869009370	thiamine pyrophosphate protein; Provisional; Region: PRK08273
76869009371	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
76869009372	PYR/PP interface [polypeptide binding]; other site
76869009373	dimer interface [polypeptide binding]; other site
76869009374	tetramer interface [polypeptide binding]; other site
76869009375	TPP binding site [chemical binding]; other site
76869009376	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869009377	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
76869009378	TPP-binding site [chemical binding]; other site
76869009379	Protein of unknown function DUF72; Region: DUF72; pfam01904
76869009380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009382	putative transposase OrfB; Reviewed; Region: PHA02517
76869009383	HTH-like domain; Region: HTH_21; pfam13276
76869009384	Integrase core domain; Region: rve; pfam00665
76869009385	Integrase core domain; Region: rve_2; pfam13333
76869009386	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
76869009387	Transposase; Region: HTH_Tnp_1; pfam01527
76869009388	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009389	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869009390	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009391	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
76869009392	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
76869009393	nudix motif; other site
76869009394	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
76869009395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869009396	S-adenosylmethionine binding site [chemical binding]; other site
76869009397	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
76869009398	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869009399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009400	putative substrate translocation pore; other site
76869009401	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
76869009402	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869009403	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
76869009404	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869009405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009407	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
76869009408	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
76869009409	NAD binding site [chemical binding]; other site
76869009410	catalytic Zn binding site [ion binding]; other site
76869009411	structural Zn binding site [ion binding]; other site
76869009412	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
76869009413	short chain dehydrogenase; Provisional; Region: PRK06139
76869009414	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
76869009415	putative NAD(P) binding site [chemical binding]; other site
76869009416	active site
76869009417	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
76869009418	intracellular protease, PfpI family; Region: PfpI; TIGR01382
76869009419	proposed catalytic triad [active]
76869009420	conserved cys residue [active]
76869009421	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869009422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869009423	dimer interface [polypeptide binding]; other site
76869009424	phosphorylation site [posttranslational modification]
76869009425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009426	ATP binding site [chemical binding]; other site
76869009427	Mg2+ binding site [ion binding]; other site
76869009428	G-X-G motif; other site
76869009429	Response regulator receiver domain; Region: Response_reg; pfam00072
76869009430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009431	active site
76869009432	phosphorylation site [posttranslational modification]
76869009433	intermolecular recognition site; other site
76869009434	Response regulator receiver domain; Region: Response_reg; pfam00072
76869009435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009436	active site
76869009437	phosphorylation site [posttranslational modification]
76869009438	intermolecular recognition site; other site
76869009439	dimerization interface [polypeptide binding]; other site
76869009440	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869009441	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
76869009442	catalytic site [active]
76869009443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869009444	PAS domain; Region: PAS_9; pfam13426
76869009445	putative active site [active]
76869009446	heme pocket [chemical binding]; other site
76869009447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869009448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869009449	dimer interface [polypeptide binding]; other site
76869009450	phosphorylation site [posttranslational modification]
76869009451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009452	ATP binding site [chemical binding]; other site
76869009453	Mg2+ binding site [ion binding]; other site
76869009454	G-X-G motif; other site
76869009455	Low affinity iron permease; Region: Iron_permease; pfam04120
76869009456	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869009457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009458	active site
76869009459	phosphorylation site [posttranslational modification]
76869009460	intermolecular recognition site; other site
76869009461	dimerization interface [polypeptide binding]; other site
76869009462	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
76869009463	minor groove reading motif; other site
76869009464	helix-hairpin-helix signature motif; other site
76869009465	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
76869009466	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
76869009467	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
76869009468	metal binding site [ion binding]; metal-binding site
76869009469	short chain dehydrogenase; Provisional; Region: PRK06701
76869009470	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
76869009471	NAD binding site [chemical binding]; other site
76869009472	metal binding site [ion binding]; metal-binding site
76869009473	active site
76869009474	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
76869009475	Predicted membrane protein [Function unknown]; Region: COG2323
76869009476	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
76869009477	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
76869009478	Hemerythrin-like domain; Region: Hr-like; cd12108
76869009479	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
76869009480	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
76869009481	NAD binding site [chemical binding]; other site
76869009482	catalytic Zn binding site [ion binding]; other site
76869009483	structural Zn binding site [ion binding]; other site
76869009484	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
76869009485	putative catalytic site [active]
76869009486	putative phosphate binding site [ion binding]; other site
76869009487	active site
76869009488	metal binding site A [ion binding]; metal-binding site
76869009489	DNA binding site [nucleotide binding]
76869009490	putative AP binding site [nucleotide binding]; other site
76869009491	putative metal binding site B [ion binding]; other site
76869009492	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
76869009493	intracellular protease, PfpI family; Region: PfpI; TIGR01382
76869009494	proposed catalytic triad [active]
76869009495	conserved cys residue [active]
76869009496	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
76869009497	carboxylate-amine ligase; Provisional; Region: PRK13515
76869009498	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
76869009499	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
76869009500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869009501	S-adenosylmethionine binding site [chemical binding]; other site
76869009502	CheB methylesterase; Region: CheB_methylest; pfam01339
76869009503	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
76869009504	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
76869009505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869009506	S-adenosylmethionine binding site [chemical binding]; other site
76869009507	PAS fold; Region: PAS; pfam00989
76869009508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869009509	putative active site [active]
76869009510	heme pocket [chemical binding]; other site
76869009511	PAS domain; Region: PAS_10; pfam13596
76869009512	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
76869009513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869009514	putative active site [active]
76869009515	heme pocket [chemical binding]; other site
76869009516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869009517	dimer interface [polypeptide binding]; other site
76869009518	phosphorylation site [posttranslational modification]
76869009519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009520	ATP binding site [chemical binding]; other site
76869009521	Mg2+ binding site [ion binding]; other site
76869009522	G-X-G motif; other site
76869009523	Response regulator receiver domain; Region: Response_reg; pfam00072
76869009524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009525	active site
76869009526	phosphorylation site [posttranslational modification]
76869009527	intermolecular recognition site; other site
76869009528	dimerization interface [polypeptide binding]; other site
76869009529	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
76869009530	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
76869009531	[2Fe-2S] cluster binding site [ion binding]; other site
76869009532	Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848
76869009533	hydrophobic ligand binding site; other site
76869009534	choline dehydrogenase; Validated; Region: PRK02106
76869009535	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869009536	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869009537	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869009538	conserved cys residue [active]
76869009539	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009541	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
76869009542	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
76869009543	hypothetical protein; Provisional; Region: PRK07490
76869009544	active site
76869009545	intersubunit interface [polypeptide binding]; other site
76869009546	Zn2+ binding site [ion binding]; other site
76869009547	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
76869009548	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869009549	tetramerization interface [polypeptide binding]; other site
76869009550	NAD(P) binding site [chemical binding]; other site
76869009551	catalytic residues [active]
76869009552	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
76869009553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869009554	Coenzyme A binding pocket [chemical binding]; other site
76869009555	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
76869009556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
76869009557	ACT domain; Region: ACT_3; pfam10000
76869009558	Family description; Region: ACT_7; pfam13840
76869009559	Uncharacterized conserved protein [Function unknown]; Region: COG5361
76869009560	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
76869009561	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
76869009562	Uncharacterized conserved protein [Function unknown]; Region: COG5361
76869009563	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
76869009564	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
76869009565	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
76869009566	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
76869009567	putative NAD(P) binding site [chemical binding]; other site
76869009568	active site
76869009569	putative substrate binding site [chemical binding]; other site
76869009570	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
76869009571	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
76869009572	DNA binding residues [nucleotide binding]
76869009573	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869009574	active site
76869009575	DNA binding site [nucleotide binding]
76869009576	Int/Topo IB signature motif; other site
76869009577	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
76869009578	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
76869009579	Uncharacterized conserved protein [Function unknown]; Region: COG5361
76869009580	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
76869009581	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
76869009582	Uncharacterized conserved protein [Function unknown]; Region: COG5361
76869009583	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
76869009584	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
76869009585	OsmC-like protein; Region: OsmC; cl00767
76869009586	Outer membrane efflux protein; Region: OEP; pfam02321
76869009587	HlyD family secretion protein; Region: HlyD_2; pfam12700
76869009588	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869009589	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
76869009590	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
76869009591	PAS fold; Region: PAS_3; pfam08447
76869009592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869009593	putative active site [active]
76869009594	heme pocket [chemical binding]; other site
76869009595	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869009596	putative CheW interface [polypeptide binding]; other site
76869009597	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
76869009598	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
76869009599	TrkA-C domain; Region: TrkA_C; pfam02080
76869009600	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
76869009601	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
76869009602	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
76869009603	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869009604	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869009605	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
76869009606	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869009607	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
76869009608	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
76869009609	Sulfatase; Region: Sulfatase; pfam00884
76869009610	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
76869009611	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
76869009612	Oxygen tolerance; Region: BatD; pfam13584
76869009613	von Willebrand factor type A domain; Region: VWA_2; pfam13519
76869009614	metal ion-dependent adhesion site (MIDAS); other site
76869009615	TPR repeat; Region: TPR_11; pfam13414
76869009616	Tetratricopeptide repeat; Region: TPR_1; pfam00515
76869009617	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
76869009618	metal ion-dependent adhesion site (MIDAS); other site
76869009619	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
76869009620	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
76869009621	Protein of unknown function DUF58; Region: DUF58; pfam01882
76869009622	MoxR-like ATPases [General function prediction only]; Region: COG0714
76869009623	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
76869009624	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
76869009625	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
76869009626	HEAT repeats; Region: HEAT_2; pfam13646
76869009627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869009628	binding surface
76869009629	TPR motif; other site
76869009630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869009631	binding surface
76869009632	Tetratricopeptide repeat; Region: TPR_16; pfam13432
76869009633	TPR motif; other site
76869009634	Tetratricopeptide repeat; Region: TPR_16; pfam13432
76869009635	Uncharacterized conserved protein [Function unknown]; Region: COG5361
76869009636	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869009637	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869009638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869009639	DNA-binding site [nucleotide binding]; DNA binding site
76869009640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869009641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869009642	homodimer interface [polypeptide binding]; other site
76869009643	catalytic residue [active]
76869009644	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
76869009645	RNA polymerase sigma factor; Provisional; Region: PRK12536
76869009646	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869009647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869009648	DNA binding residues [nucleotide binding]
76869009649	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
76869009650	hypothetical protein; Provisional; Region: PRK05409
76869009651	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
76869009652	Predicted membrane protein [Function unknown]; Region: COG2259
76869009653	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869009654	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
76869009655	conserved cys residue [active]
76869009656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869009657	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
76869009658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869009659	NAD(P) binding site [chemical binding]; other site
76869009660	active site
76869009661	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
76869009662	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
76869009663	putative NAD(P) binding site [chemical binding]; other site
76869009664	dimer interface [polypeptide binding]; other site
76869009665	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869009666	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869009667	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869009668	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869009669	Peptidase family M50; Region: Peptidase_M50; pfam02163
76869009670	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
76869009671	active site
76869009672	putative substrate binding region [chemical binding]; other site
76869009673	multidrug resistance protein MdtN; Provisional; Region: PRK10476
76869009674	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869009675	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
76869009676	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009677	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009678	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009679	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009680	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009681	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009682	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009683	VCBS repeat; Region: VCBS_repeat; TIGR01965
76869009684	Outer membrane efflux protein; Region: OEP; pfam02321
76869009685	Outer membrane efflux protein; Region: OEP; pfam02321
76869009686	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869009687	dimerization interface [polypeptide binding]; other site
76869009688	putative DNA binding site [nucleotide binding]; other site
76869009689	putative Zn2+ binding site [ion binding]; other site
76869009690	arsenical pump membrane protein; Provisional; Region: PRK15445
76869009691	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
76869009692	transmembrane helices; other site
76869009693	Low molecular weight phosphatase family; Region: LMWPc; cd00115
76869009694	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
76869009695	active site
76869009696	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
76869009697	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869009698	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
76869009699	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
76869009700	metal binding site [ion binding]; metal-binding site
76869009701	putative dimer interface [polypeptide binding]; other site
76869009702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009703	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869009704	putative substrate translocation pore; other site
76869009705	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
76869009706	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
76869009707	trimer interface [polypeptide binding]; other site
76869009708	eyelet of channel; other site
76869009709	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869009712	dimerization interface [polypeptide binding]; other site
76869009713	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
76869009714	catalytic triad [active]
76869009715	dimer interface [polypeptide binding]; other site
76869009716	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
76869009717	methionine synthase; Provisional; Region: PRK01207
76869009718	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
76869009719	substrate binding site [chemical binding]; other site
76869009720	THF binding site; other site
76869009721	zinc-binding site [ion binding]; other site
76869009722	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
76869009723	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
76869009724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009725	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
76869009726	putative dimerization interface [polypeptide binding]; other site
76869009727	lipoyl synthase; Provisional; Region: PRK05481
76869009728	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869009729	FeS/SAM binding site; other site
76869009730	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
76869009731	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
76869009732	dimer interface [polypeptide binding]; other site
76869009733	active site
76869009734	glycine-pyridoxal phosphate binding site [chemical binding]; other site
76869009735	folate binding site [chemical binding]; other site
76869009736	glycine dehydrogenase; Provisional; Region: PRK05367
76869009737	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
76869009738	tetramer interface [polypeptide binding]; other site
76869009739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869009740	catalytic residue [active]
76869009741	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
76869009742	tetramer interface [polypeptide binding]; other site
76869009743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869009744	catalytic residue [active]
76869009745	glycine cleavage system protein H; Provisional; Region: PRK13380
76869009746	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
76869009747	lipoyl attachment site [posttranslational modification]; other site
76869009748	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
76869009749	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
76869009750	putative aromatic amino acid binding site; other site
76869009751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869009752	Walker A motif; other site
76869009753	ATP binding site [chemical binding]; other site
76869009754	Walker B motif; other site
76869009755	arginine finger; other site
76869009756	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
76869009757	choline dehydrogenase; Validated; Region: PRK02106
76869009758	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869009759	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
76869009760	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869009761	Na binding site [ion binding]; other site
76869009762	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869009763	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869009764	NAD(P) binding site [chemical binding]; other site
76869009765	catalytic residues [active]
76869009766	agmatinase; Region: agmatinase; TIGR01230
76869009767	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
76869009768	oligomer interface [polypeptide binding]; other site
76869009769	active site
76869009770	Mn binding site [ion binding]; other site
76869009771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009773	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869009774	dimerization interface [polypeptide binding]; other site
76869009775	Uncharacterized conserved protein [Function unknown]; Region: COG2308
76869009776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
76869009777	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
76869009778	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
76869009779	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
76869009780	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
76869009781	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
76869009782	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
76869009783	GntP family permease; Region: GntP_permease; pfam02447
76869009784	fructuronate transporter; Provisional; Region: PRK10034; cl15264
76869009785	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
76869009786	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
76869009787	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869009788	catalytic residue [active]
76869009789	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
76869009790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009791	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
76869009792	dimerization interface [polypeptide binding]; other site
76869009793	substrate binding pocket [chemical binding]; other site
76869009794	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869009795	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869009796	Walker A motif; other site
76869009797	ATP binding site [chemical binding]; other site
76869009798	Walker B motif; other site
76869009799	arginine finger; other site
76869009800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869009801	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869009802	Walker A motif; other site
76869009803	ATP binding site [chemical binding]; other site
76869009804	Walker B motif; other site
76869009805	arginine finger; other site
76869009806	Predicted transcriptional regulator [Transcription]; Region: COG2378
76869009807	WYL domain; Region: WYL; pfam13280
76869009808	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
76869009809	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
76869009810	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
76869009811	PAS domain; Region: PAS_8; pfam13188
76869009812	PAS domain S-box; Region: sensory_box; TIGR00229
76869009813	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
76869009814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869009815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869009816	dimer interface [polypeptide binding]; other site
76869009817	phosphorylation site [posttranslational modification]
76869009818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009819	ATP binding site [chemical binding]; other site
76869009820	Mg2+ binding site [ion binding]; other site
76869009821	G-X-G motif; other site
76869009822	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869009823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009824	active site
76869009825	phosphorylation site [posttranslational modification]
76869009826	intermolecular recognition site; other site
76869009827	dimerization interface [polypeptide binding]; other site
76869009828	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
76869009829	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
76869009830	putative active site [active]
76869009831	metal binding site [ion binding]; metal-binding site
76869009832	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
76869009833	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869009834	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869009835	NAD(P) binding site [chemical binding]; other site
76869009836	catalytic residues [active]
76869009837	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
76869009838	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
76869009839	dimer interface [polypeptide binding]; other site
76869009840	Trp docking motif [polypeptide binding]; other site
76869009841	active site
76869009842	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
76869009843	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
76869009844	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
76869009845	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869009846	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869009847	substrate binding pocket [chemical binding]; other site
76869009848	membrane-bound complex binding site; other site
76869009849	hinge residues; other site
76869009850	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869009851	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
76869009852	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
76869009853	dimer interface [polypeptide binding]; other site
76869009854	Trp docking motif [polypeptide binding]; other site
76869009855	active site
76869009856	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
76869009857	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
76869009858	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
76869009859	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
76869009860	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
76869009861	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869009862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009863	active site
76869009864	phosphorylation site [posttranslational modification]
76869009865	intermolecular recognition site; other site
76869009866	dimerization interface [polypeptide binding]; other site
76869009867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869009868	DNA binding residues [nucleotide binding]
76869009869	dimerization interface [polypeptide binding]; other site
76869009870	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869009871	dimerization interface [polypeptide binding]; other site
76869009872	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
76869009873	Histidine kinase; Region: HisKA_3; pfam07730
76869009874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009875	ATP binding site [chemical binding]; other site
76869009876	Mg2+ binding site [ion binding]; other site
76869009877	G-X-G motif; other site
76869009878	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
76869009879	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
76869009880	ligand binding site [chemical binding]; other site
76869009881	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
76869009882	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869009883	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869009884	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869009885	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869009886	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
76869009887	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
76869009888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869009889	Walker A/P-loop; other site
76869009890	ATP binding site [chemical binding]; other site
76869009891	Q-loop/lid; other site
76869009892	ABC transporter signature motif; other site
76869009893	Walker B; other site
76869009894	D-loop; other site
76869009895	H-loop/switch region; other site
76869009896	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
76869009897	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
76869009898	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
76869009899	active site residue [active]
76869009900	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869009901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009902	active site
76869009903	phosphorylation site [posttranslational modification]
76869009904	intermolecular recognition site; other site
76869009905	dimerization interface [polypeptide binding]; other site
76869009906	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869009907	DNA binding residues [nucleotide binding]
76869009908	dimerization interface [polypeptide binding]; other site
76869009909	PAS fold; Region: PAS; pfam00989
76869009910	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869009911	putative active site [active]
76869009912	heme pocket [chemical binding]; other site
76869009913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869009914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869009915	dimer interface [polypeptide binding]; other site
76869009916	phosphorylation site [posttranslational modification]
76869009917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869009918	ATP binding site [chemical binding]; other site
76869009919	Mg2+ binding site [ion binding]; other site
76869009920	G-X-G motif; other site
76869009921	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869009922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869009923	active site
76869009924	phosphorylation site [posttranslational modification]
76869009925	intermolecular recognition site; other site
76869009926	dimerization interface [polypeptide binding]; other site
76869009927	Uncharacterized conserved protein [Function unknown]; Region: COG3287
76869009928	FIST N domain; Region: FIST; pfam08495
76869009929	FIST C domain; Region: FIST_C; pfam10442
76869009930	Gram-negative porin; Region: Porin_4; pfam13609
76869009931	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
76869009932	active site
76869009933	motif I; other site
76869009934	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
76869009935	motif II; other site
76869009936	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
76869009937	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
76869009938	Walker A/P-loop; other site
76869009939	ATP binding site [chemical binding]; other site
76869009940	Q-loop/lid; other site
76869009941	ABC transporter signature motif; other site
76869009942	Walker B; other site
76869009943	D-loop; other site
76869009944	H-loop/switch region; other site
76869009945	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
76869009946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869009947	dimer interface [polypeptide binding]; other site
76869009948	conserved gate region; other site
76869009949	putative PBP binding loops; other site
76869009950	ABC-ATPase subunit interface; other site
76869009951	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
76869009952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869009953	dimer interface [polypeptide binding]; other site
76869009954	conserved gate region; other site
76869009955	putative PBP binding loops; other site
76869009956	ABC-ATPase subunit interface; other site
76869009957	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
76869009958	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
76869009959	MAPEG family; Region: MAPEG; pfam01124
76869009960	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
76869009961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869009962	D-galactonate transporter; Region: 2A0114; TIGR00893
76869009963	putative substrate translocation pore; other site
76869009964	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
76869009965	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
76869009966	putative active site [active]
76869009967	metal binding site [ion binding]; metal-binding site
76869009968	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869009969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869009970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869009971	dimerization interface [polypeptide binding]; other site
76869009972	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
76869009973	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
76869009974	Flavin binding site [chemical binding]; other site
76869009975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869009976	ABC-ATPase subunit interface; other site
76869009977	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
76869009978	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
76869009979	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
76869009980	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
76869009981	Walker A/P-loop; other site
76869009982	ATP binding site [chemical binding]; other site
76869009983	Q-loop/lid; other site
76869009984	ABC transporter signature motif; other site
76869009985	Walker B; other site
76869009986	D-loop; other site
76869009987	H-loop/switch region; other site
76869009988	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
76869009989	active site residue [active]
76869009990	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
76869009991	active site residue [active]
76869009992	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
76869009993	active site residue [active]
76869009994	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
76869009995	active site residue [active]
76869009996	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
76869009997	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
76869009998	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869009999	catalytic residue [active]
76869010000	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
76869010001	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869010002	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869010003	Walker A/P-loop; other site
76869010004	ATP binding site [chemical binding]; other site
76869010005	Q-loop/lid; other site
76869010006	ABC transporter signature motif; other site
76869010007	Walker B; other site
76869010008	D-loop; other site
76869010009	H-loop/switch region; other site
76869010010	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869010011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010012	dimer interface [polypeptide binding]; other site
76869010013	conserved gate region; other site
76869010014	putative PBP binding loops; other site
76869010015	ABC-ATPase subunit interface; other site
76869010016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010017	dimer interface [polypeptide binding]; other site
76869010018	conserved gate region; other site
76869010019	putative PBP binding loops; other site
76869010020	ABC-ATPase subunit interface; other site
76869010021	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869010022	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869010023	substrate binding pocket [chemical binding]; other site
76869010024	membrane-bound complex binding site; other site
76869010025	hinge residues; other site
76869010026	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869010027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010028	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
76869010029	putative dimerization interface [polypeptide binding]; other site
76869010030	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869010031	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869010032	dimerization interface [polypeptide binding]; other site
76869010033	putative DNA binding site [nucleotide binding]; other site
76869010034	putative Zn2+ binding site [ion binding]; other site
76869010035	AsnC family; Region: AsnC_trans_reg; pfam01037
76869010036	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
76869010037	Predicted membrane protein [Function unknown]; Region: COG4541
76869010038	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869010039	Ligand Binding Site [chemical binding]; other site
76869010040	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869010041	Ligand Binding Site [chemical binding]; other site
76869010042	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
76869010043	Cupin superfamily protein; Region: Cupin_4; pfam08007
76869010044	Cupin-like domain; Region: Cupin_8; pfam13621
76869010045	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
76869010046	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869010047	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869010048	Walker A/P-loop; other site
76869010049	ATP binding site [chemical binding]; other site
76869010050	ABC transporter signature motif; other site
76869010051	Walker B; other site
76869010052	D-loop; other site
76869010053	H-loop/switch region; other site
76869010054	Uncharacterized conserved protein [Function unknown]; Region: COG4278
76869010055	AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061
76869010056	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
76869010057	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
76869010058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869010059	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
76869010060	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869010061	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869010062	putative DNA binding site [nucleotide binding]; other site
76869010063	putative Zn2+ binding site [ion binding]; other site
76869010064	AsnC family; Region: AsnC_trans_reg; pfam01037
76869010065	threonine and homoserine efflux system; Provisional; Region: PRK10532
76869010066	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
76869010067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010068	putative substrate translocation pore; other site
76869010069	magnesium-transporting ATPase; Provisional; Region: PRK15122
76869010070	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
76869010071	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869010072	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
76869010073	Soluble P-type ATPase [General function prediction only]; Region: COG4087
76869010074	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
76869010075	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869010076	dimerization interface [polypeptide binding]; other site
76869010077	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869010078	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869010079	dimer interface [polypeptide binding]; other site
76869010080	putative CheW interface [polypeptide binding]; other site
76869010081	PGAP1-like protein; Region: PGAP1; pfam07819
76869010082	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869010083	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
76869010084	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869010085	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869010086	DNA-binding site [nucleotide binding]; DNA binding site
76869010087	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869010088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869010089	homodimer interface [polypeptide binding]; other site
76869010090	catalytic residue [active]
76869010091	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
76869010092	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869010093	catalytic loop [active]
76869010094	iron binding site [ion binding]; other site
76869010095	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
76869010096	FAD binding pocket [chemical binding]; other site
76869010097	conserved FAD binding motif [chemical binding]; other site
76869010098	phosphate binding motif [ion binding]; other site
76869010099	beta-alpha-beta structure motif; other site
76869010100	NAD binding pocket [chemical binding]; other site
76869010101	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
76869010102	active site
76869010103	Protein of unknown function DUF262; Region: DUF262; pfam03235
76869010104	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
76869010105	Class I aldolases; Region: Aldolase_Class_I; cl17187
76869010106	catalytic residue [active]
76869010107	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
76869010108	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
76869010109	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
76869010110	dimer interface [polypeptide binding]; other site
76869010111	active site
76869010112	catalytic residue [active]
76869010113	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
76869010114	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869010115	binding surface
76869010116	TPR motif; other site
76869010117	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
76869010118	endo-1,4-D-glucanase; Provisional; Region: PRK11097
76869010119	cellulose synthase regulator protein; Provisional; Region: PRK11114
76869010120	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
76869010121	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
76869010122	DXD motif; other site
76869010123	PilZ domain; Region: PilZ; pfam07238
76869010124	YhjQ protein; Region: YhjQ; pfam06564
76869010125	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
76869010126	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
76869010127	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
76869010128	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
76869010129	Protein of unknown function (DUF2819); Region: DUF2819; cl17862
76869010130	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
76869010131	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869010132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869010133	Walker A/P-loop; other site
76869010134	ATP binding site [chemical binding]; other site
76869010135	Q-loop/lid; other site
76869010136	ABC transporter signature motif; other site
76869010137	Walker B; other site
76869010138	D-loop; other site
76869010139	H-loop/switch region; other site
76869010140	Transcriptional regulator [Transcription]; Region: IclR; COG1414
76869010141	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869010142	putative DNA binding site [nucleotide binding]; other site
76869010143	Bacterial transcriptional regulator; Region: IclR; pfam01614
76869010144	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
76869010145	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869010146	Walker A/P-loop; other site
76869010147	ATP binding site [chemical binding]; other site
76869010148	Q-loop/lid; other site
76869010149	ABC transporter signature motif; other site
76869010150	Walker B; other site
76869010151	D-loop; other site
76869010152	H-loop/switch region; other site
76869010153	TOBE domain; Region: TOBE_2; pfam08402
76869010154	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
76869010155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010156	dimer interface [polypeptide binding]; other site
76869010157	conserved gate region; other site
76869010158	putative PBP binding loops; other site
76869010159	ABC-ATPase subunit interface; other site
76869010160	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
76869010161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010162	dimer interface [polypeptide binding]; other site
76869010163	conserved gate region; other site
76869010164	putative PBP binding loops; other site
76869010165	ABC-ATPase subunit interface; other site
76869010166	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
76869010167	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
76869010168	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869010169	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869010170	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869010171	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
76869010172	outer membrane porin, OprD family; Region: OprD; pfam03573
76869010173	hypothetical protein; Provisional; Region: PRK06486
76869010174	active site
76869010175	intersubunit interface [polypeptide binding]; other site
76869010176	Zn2+ binding site [ion binding]; other site
76869010177	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
76869010178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010179	putative substrate translocation pore; other site
76869010180	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869010181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869010182	DNA-binding site [nucleotide binding]; DNA binding site
76869010183	FCD domain; Region: FCD; pfam07729
76869010184	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
76869010185	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
76869010186	Bacterial transcriptional regulator; Region: IclR; pfam01614
76869010187	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
76869010188	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
76869010189	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
76869010190	shikimate binding site; other site
76869010191	NAD(P) binding site [chemical binding]; other site
76869010192	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
76869010193	Predicted oxidoreductase [General function prediction only]; Region: COG3573
76869010194	NIPSNAP; Region: NIPSNAP; pfam07978
76869010195	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
76869010196	Predicted oxidoreductase [General function prediction only]; Region: COG3573
76869010197	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
76869010198	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
76869010199	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
76869010200	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
76869010201	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
76869010202	Protein of unknown function (DUF3121); Region: DUF3121; pfam11319
76869010203	Protein of unknown function (DUF770); Region: DUF770; pfam05591
76869010204	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
76869010205	Protein of unknown function (DUF877); Region: DUF877; pfam05943
76869010206	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
76869010207	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
76869010208	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
76869010209	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
76869010210	FHA domain; Region: FHA; pfam00498
76869010211	phosphopeptide binding site; other site
76869010212	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
76869010213	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
76869010214	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
76869010215	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
76869010216	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
76869010217	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
76869010218	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
76869010219	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
76869010220	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
76869010221	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
76869010222	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
76869010223	PAAR motif; Region: PAAR_motif; pfam05488
76869010224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010225	D-galactonate transporter; Region: 2A0114; TIGR00893
76869010226	putative substrate translocation pore; other site
76869010227	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
76869010228	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
76869010229	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
76869010230	Transcriptional regulator [Transcription]; Region: IclR; COG1414
76869010231	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
76869010232	Bacterial transcriptional regulator; Region: IclR; pfam01614
76869010233	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
76869010234	Predicted oxidoreductase [General function prediction only]; Region: COG3573
76869010235	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869010236	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
76869010237	NAD(P) binding site [chemical binding]; other site
76869010238	catalytic residues [active]
76869010239	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
76869010240	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
76869010241	catalytic Zn binding site [ion binding]; other site
76869010242	NAD binding site [chemical binding]; other site
76869010243	structural Zn binding site [ion binding]; other site
76869010244	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
76869010245	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
76869010246	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869010247	Walker A motif; other site
76869010248	ATP binding site [chemical binding]; other site
76869010249	Walker B motif; other site
76869010250	arginine finger; other site
76869010251	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
76869010252	DNA-binding interface [nucleotide binding]; DNA binding site
76869010253	Cache domain; Region: Cache_1; pfam02743
76869010254	GAF domain; Region: GAF_3; pfam13492
76869010255	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
76869010256	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
76869010257	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869010258	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
76869010259	NAD(P) binding site [chemical binding]; other site
76869010260	catalytic residues [active]
76869010261	putative aminotransferase; Provisional; Region: PRK12403
76869010262	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869010263	inhibitor-cofactor binding pocket; inhibition site
76869010264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869010265	catalytic residue [active]
76869010266	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869010267	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869010268	DNA binding residues [nucleotide binding]
76869010269	dimerization interface [polypeptide binding]; other site
76869010270	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869010271	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
76869010272	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
76869010273	dimer interface [polypeptide binding]; other site
76869010274	NADP binding site [chemical binding]; other site
76869010275	catalytic residues [active]
76869010276	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
76869010277	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010278	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869010279	dimerization interface [polypeptide binding]; other site
76869010280	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
76869010281	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869010282	substrate binding pocket [chemical binding]; other site
76869010283	membrane-bound complex binding site; other site
76869010284	hinge residues; other site
76869010285	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
76869010286	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
76869010287	Walker A/P-loop; other site
76869010288	ATP binding site [chemical binding]; other site
76869010289	Q-loop/lid; other site
76869010290	ABC transporter signature motif; other site
76869010291	Walker B; other site
76869010292	D-loop; other site
76869010293	H-loop/switch region; other site
76869010294	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
76869010295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010296	dimer interface [polypeptide binding]; other site
76869010297	conserved gate region; other site
76869010298	putative PBP binding loops; other site
76869010299	ABC-ATPase subunit interface; other site
76869010300	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
76869010301	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
76869010302	putative active site [active]
76869010303	metal binding site [ion binding]; metal-binding site
76869010304	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
76869010305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010306	putative substrate translocation pore; other site
76869010307	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010308	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
76869010309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869010310	dimerization interface [polypeptide binding]; other site
76869010311	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
76869010312	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869010313	motif II; other site
76869010314	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
76869010315	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
76869010316	active site
76869010317	putative substrate binding pocket [chemical binding]; other site
76869010318	xanthine permease; Region: pbuX; TIGR03173
76869010319	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
76869010320	classical (c) SDRs; Region: SDR_c; cd05233
76869010321	NAD(P) binding site [chemical binding]; other site
76869010322	active site
76869010323	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869010324	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010325	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
76869010326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869010327	Coenzyme A binding pocket [chemical binding]; other site
76869010328	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869010329	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869010330	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869010331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010332	dimer interface [polypeptide binding]; other site
76869010333	conserved gate region; other site
76869010334	putative PBP binding loops; other site
76869010335	ABC-ATPase subunit interface; other site
76869010336	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
76869010337	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869010338	Walker A/P-loop; other site
76869010339	ATP binding site [chemical binding]; other site
76869010340	Q-loop/lid; other site
76869010341	ABC transporter signature motif; other site
76869010342	Walker B; other site
76869010343	D-loop; other site
76869010344	H-loop/switch region; other site
76869010345	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
76869010346	heme binding pocket [chemical binding]; other site
76869010347	heme ligand [chemical binding]; other site
76869010348	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
76869010349	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
76869010350	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
76869010351	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
76869010352	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
76869010353	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
76869010354	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
76869010355	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869010356	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869010357	DNA-binding site [nucleotide binding]; DNA binding site
76869010358	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869010359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869010360	homodimer interface [polypeptide binding]; other site
76869010361	catalytic residue [active]
76869010362	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
76869010363	aspartate aminotransferase; Provisional; Region: PRK05764
76869010364	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869010365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869010366	homodimer interface [polypeptide binding]; other site
76869010367	catalytic residue [active]
76869010368	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869010369	MarR family; Region: MarR_2; pfam12802
76869010370	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869010371	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869010372	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010373	N-terminal plug; other site
76869010374	ligand-binding site [chemical binding]; other site
76869010375	fec operon regulator FecR; Reviewed; Region: PRK09774
76869010376	FecR protein; Region: FecR; pfam04773
76869010377	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869010378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869010379	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869010380	DNA binding residues [nucleotide binding]
76869010381	hypothetical protein; Provisional; Region: PRK10649
76869010382	Sulfatase; Region: Sulfatase; pfam00884
76869010383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869010384	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
76869010385	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
76869010386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010387	putative substrate translocation pore; other site
76869010388	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869010389	Protein of unknown function (DUF330); Region: DUF330; pfam03886
76869010390	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
76869010391	mce related protein; Region: MCE; pfam02470
76869010392	mce related protein; Region: MCE; pfam02470
76869010393	mce related protein; Region: MCE; pfam02470
76869010394	Paraquat-inducible protein A; Region: PqiA; pfam04403
76869010395	Paraquat-inducible protein A; Region: PqiA; pfam04403
76869010396	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869010397	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010398	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
76869010399	putative substrate binding pocket [chemical binding]; other site
76869010400	dimerization interface [polypeptide binding]; other site
76869010401	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869010402	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
76869010403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010404	putative substrate translocation pore; other site
76869010405	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869010406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869010407	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
76869010408	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
76869010409	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869010410	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
76869010411	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
76869010412	dimer interface [polypeptide binding]; other site
76869010413	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869010414	metal binding site [ion binding]; metal-binding site
76869010415	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869010416	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869010417	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
76869010418	Leucine-rich repeats; other site
76869010419	Substrate binding site [chemical binding]; other site
76869010420	Leucine rich repeat; Region: LRR_8; pfam13855
76869010421	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
76869010422	Pirin-related protein [General function prediction only]; Region: COG1741
76869010423	Pirin; Region: Pirin; pfam02678
76869010424	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
76869010425	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
76869010426	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869010427	catalytic loop [active]
76869010428	iron binding site [ion binding]; other site
76869010429	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
76869010430	FAD binding pocket [chemical binding]; other site
76869010431	FAD binding motif [chemical binding]; other site
76869010432	phosphate binding motif [ion binding]; other site
76869010433	beta-alpha-beta structure motif; other site
76869010434	NAD binding pocket [chemical binding]; other site
76869010435	Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663
76869010436	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
76869010437	dimerization interface [polypeptide binding]; other site
76869010438	putative path to active site cavity [active]
76869010439	diiron center [ion binding]; other site
76869010440	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
76869010441	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
76869010442	dimerization interface [polypeptide binding]; other site
76869010443	Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099
76869010444	Activator of aromatic catabolism; Region: XylR_N; pfam06505
76869010445	V4R domain; Region: V4R; pfam02830
76869010446	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
76869010447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869010448	Walker A motif; other site
76869010449	ATP binding site [chemical binding]; other site
76869010450	Walker B motif; other site
76869010451	arginine finger; other site
76869010452	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869010453	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
76869010454	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
76869010455	dimer interface [polypeptide binding]; other site
76869010456	active site
76869010457	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869010458	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
76869010459	acyl-activating enzyme (AAE) consensus motif; other site
76869010460	AMP binding site [chemical binding]; other site
76869010461	Acyltransferase family; Region: Acyl_transf_3; pfam01757
76869010462	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869010463	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869010464	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869010465	DNA binding residues [nucleotide binding]
76869010466	fec operon regulator FecR; Reviewed; Region: PRK09774
76869010467	FecR protein; Region: FecR; pfam04773
76869010468	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869010469	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
76869010470	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010471	N-terminal plug; other site
76869010472	ligand-binding site [chemical binding]; other site
76869010473	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
76869010474	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869010475	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869010476	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010477	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
76869010478	dimerization interface [polypeptide binding]; other site
76869010479	substrate binding pocket [chemical binding]; other site
76869010480	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
76869010481	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
76869010482	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
76869010483	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
76869010484	Isochorismatase family; Region: Isochorismatase; pfam00857
76869010485	catalytic triad [active]
76869010486	conserved cis-peptide bond; other site
76869010487	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869010488	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
76869010489	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010490	N-terminal plug; other site
76869010491	ligand-binding site [chemical binding]; other site
76869010492	fec operon regulator FecR; Reviewed; Region: PRK09774
76869010493	FecR protein; Region: FecR; pfam04773
76869010494	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869010495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869010496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869010497	DNA binding residues [nucleotide binding]
76869010498	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869010499	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869010500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869010501	DNA binding residues [nucleotide binding]
76869010502	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869010503	FecR protein; Region: FecR; pfam04773
76869010504	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869010505	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
76869010506	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010507	N-terminal plug; other site
76869010508	ligand-binding site [chemical binding]; other site
76869010509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869010510	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
76869010511	Walker A motif; other site
76869010512	ATP binding site [chemical binding]; other site
76869010513	Walker B motif; other site
76869010514	arginine finger; other site
76869010515	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
76869010516	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
76869010517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869010518	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869010519	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
76869010520	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
76869010521	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
76869010522	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
76869010523	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
76869010524	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
76869010525	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
76869010526	active site
76869010527	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
76869010528	dimer interface [polypeptide binding]; other site
76869010529	non-prolyl cis peptide bond; other site
76869010530	insertion regions; other site
76869010531	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
76869010532	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869010533	Walker A/P-loop; other site
76869010534	ATP binding site [chemical binding]; other site
76869010535	Q-loop/lid; other site
76869010536	ABC transporter signature motif; other site
76869010537	Walker B; other site
76869010538	D-loop; other site
76869010539	H-loop/switch region; other site
76869010540	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
76869010541	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869010542	Walker A/P-loop; other site
76869010543	ATP binding site [chemical binding]; other site
76869010544	Q-loop/lid; other site
76869010545	ABC transporter signature motif; other site
76869010546	Walker B; other site
76869010547	D-loop; other site
76869010548	H-loop/switch region; other site
76869010549	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
76869010550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010551	dimer interface [polypeptide binding]; other site
76869010552	conserved gate region; other site
76869010553	putative PBP binding loops; other site
76869010554	ABC-ATPase subunit interface; other site
76869010555	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
76869010556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869010557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010558	dimer interface [polypeptide binding]; other site
76869010559	conserved gate region; other site
76869010560	putative PBP binding loops; other site
76869010561	ABC-ATPase subunit interface; other site
76869010562	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
76869010563	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
76869010564	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
76869010565	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
76869010566	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
76869010567	active site
76869010568	Zn2+ binding site [ion binding]; other site
76869010569	intersubunit interface [polypeptide binding]; other site
76869010570	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869010571	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869010572	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869010573	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
76869010574	active site
76869010575	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869010576	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
76869010577	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869010578	Walker A/P-loop; other site
76869010579	ATP binding site [chemical binding]; other site
76869010580	Q-loop/lid; other site
76869010581	ABC transporter signature motif; other site
76869010582	Walker B; other site
76869010583	D-loop; other site
76869010584	H-loop/switch region; other site
76869010585	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
76869010586	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869010587	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
76869010588	Walker A/P-loop; other site
76869010589	ATP binding site [chemical binding]; other site
76869010590	Q-loop/lid; other site
76869010591	ABC transporter signature motif; other site
76869010592	Walker B; other site
76869010593	D-loop; other site
76869010594	H-loop/switch region; other site
76869010595	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
76869010596	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
76869010597	active site
76869010598	dimer interface [polypeptide binding]; other site
76869010599	non-prolyl cis peptide bond; other site
76869010600	insertion regions; other site
76869010601	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869010602	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869010603	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
76869010604	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
76869010605	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010606	N-terminal plug; other site
76869010607	ligand-binding site [chemical binding]; other site
76869010608	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
76869010609	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010610	N-terminal plug; other site
76869010611	ligand-binding site [chemical binding]; other site
76869010612	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
76869010613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010614	dimer interface [polypeptide binding]; other site
76869010615	conserved gate region; other site
76869010616	putative PBP binding loops; other site
76869010617	ABC-ATPase subunit interface; other site
76869010618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
76869010619	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
76869010620	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
76869010621	Walker A/P-loop; other site
76869010622	ATP binding site [chemical binding]; other site
76869010623	Q-loop/lid; other site
76869010624	ABC transporter signature motif; other site
76869010625	Walker B; other site
76869010626	D-loop; other site
76869010627	H-loop/switch region; other site
76869010628	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
76869010629	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
76869010630	putative heme binding site [chemical binding]; other site
76869010631	putative substrate binding site [chemical binding]; other site
76869010632	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
76869010633	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
76869010634	putative heme binding site [chemical binding]; other site
76869010635	putative substrate binding site [chemical binding]; other site
76869010636	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
76869010637	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
76869010638	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869010639	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
76869010640	Walker A/P-loop; other site
76869010641	ATP binding site [chemical binding]; other site
76869010642	Q-loop/lid; other site
76869010643	ABC transporter signature motif; other site
76869010644	Walker B; other site
76869010645	D-loop; other site
76869010646	H-loop/switch region; other site
76869010647	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
76869010648	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
76869010649	lipoyl-biotinyl attachment site [posttranslational modification]; other site
76869010650	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869010651	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
76869010652	PAS domain S-box; Region: sensory_box; TIGR00229
76869010653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869010654	putative active site [active]
76869010655	heme pocket [chemical binding]; other site
76869010656	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869010657	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869010658	metal binding site [ion binding]; metal-binding site
76869010659	active site
76869010660	I-site; other site
76869010661	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869010662	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869010663	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010664	N-terminal plug; other site
76869010665	ligand-binding site [chemical binding]; other site
76869010666	fec operon regulator FecR; Reviewed; Region: PRK09774
76869010667	FecR protein; Region: FecR; pfam04773
76869010668	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869010669	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869010670	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869010671	DNA binding residues [nucleotide binding]
76869010672	Methyltransferase domain; Region: Methyltransf_23; pfam13489
76869010673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869010674	S-adenosylmethionine binding site [chemical binding]; other site
76869010675	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
76869010676	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
76869010677	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
76869010678	dimer interface [polypeptide binding]; other site
76869010679	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
76869010680	active site
76869010681	Fe binding site [ion binding]; other site
76869010682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010683	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869010684	putative substrate translocation pore; other site
76869010685	tyrosine decarboxylase; Region: PLN02880
76869010686	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
76869010687	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869010688	catalytic residue [active]
76869010689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869010690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010691	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
76869010692	substrate binding pocket [chemical binding]; other site
76869010693	dimerization interface [polypeptide binding]; other site
76869010694	hypothetical protein; Provisional; Region: PRK12378
76869010695	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869010696	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869010697	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
76869010698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010699	putative substrate translocation pore; other site
76869010700	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
76869010701	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010702	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869010703	dimerization interface [polypeptide binding]; other site
76869010704	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
76869010705	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
76869010706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869010707	S-adenosylmethionine binding site [chemical binding]; other site
76869010708	putative proline-specific permease; Provisional; Region: proY; PRK10580
76869010709	Spore germination protein; Region: Spore_permease; cl17796
76869010710	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
76869010711	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869010712	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010713	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869010714	dimerization interface [polypeptide binding]; other site
76869010715	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
76869010716	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869010717	active site
76869010718	Int/Topo IB signature motif; other site
76869010719	catalytic residues [active]
76869010720	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
76869010721	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
76869010722	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
76869010723	Chromate transporter; Region: Chromate_transp; pfam02417
76869010724	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
76869010725	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
76869010726	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
76869010727	catalytic residues [active]
76869010728	Putative phage tail protein; Region: Phage-tail_3; pfam13550
76869010729	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
76869010730	Phage-related minor tail protein [Function unknown]; Region: COG5281
76869010731	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
76869010732	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
76869010733	Prophage antirepressor [Transcription]; Region: COG3617
76869010734	BRO family, N-terminal domain; Region: Bro-N; smart01040
76869010735	Arc-like DNA binding domain; Region: Arc; pfam03869
76869010736	Arc-like DNA binding domain; Region: Arc; pfam03869
76869010737	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
76869010738	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
76869010739	Phage tail protein; Region: Phage_tail_3; pfam08813
76869010740	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
76869010741	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
76869010742	Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013
76869010743	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
76869010744	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
76869010745	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
76869010746	Terminase-like family; Region: Terminase_6; pfam03237
76869010747	Phage terminase large subunit; Region: Terminase_3; cl12054
76869010748	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
76869010749	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813
76869010750	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
76869010751	active site
76869010752	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
76869010753	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
76869010754	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
76869010755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869010756	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869010757	Walker A motif; other site
76869010758	ATP binding site [chemical binding]; other site
76869010759	Walker B motif; other site
76869010760	arginine finger; other site
76869010761	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869010762	dimerization interface [polypeptide binding]; other site
76869010763	putative DNA binding site [nucleotide binding]; other site
76869010764	putative Zn2+ binding site [ion binding]; other site
76869010765	Tc5 transposase DNA-binding domain; Region: HTH_Tnp_Tc5; cl12115
76869010766	Prophage antirepressor [Transcription]; Region: COG3617
76869010767	BRO family, N-terminal domain; Region: Bro-N; smart01040
76869010768	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
76869010769	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869010770	non-specific DNA binding site [nucleotide binding]; other site
76869010771	salt bridge; other site
76869010772	sequence-specific DNA binding site [nucleotide binding]; other site
76869010773	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869010774	Catalytic site [active]
76869010775	ERF superfamily; Region: ERF; pfam04404
76869010776	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
76869010777	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
76869010778	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
76869010779	DNA binding site [nucleotide binding]
76869010780	substrate interaction site [chemical binding]; other site
76869010781	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
76869010782	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
76869010783	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
76869010784	active site
76869010785	metal binding site [ion binding]; metal-binding site
76869010786	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869010787	active site
76869010788	DNA binding site [nucleotide binding]
76869010789	Int/Topo IB signature motif; other site
76869010790	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
76869010791	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
76869010792	DNA binding residues [nucleotide binding]
76869010793	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
76869010794	IHF dimer interface [polypeptide binding]; other site
76869010795	IHF - DNA interface [nucleotide binding]; other site
76869010796	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
76869010797	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
76869010798	putative tRNA-binding site [nucleotide binding]; other site
76869010799	B3/4 domain; Region: B3_4; pfam03483
76869010800	tRNA synthetase B5 domain; Region: B5; smart00874
76869010801	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
76869010802	dimer interface [polypeptide binding]; other site
76869010803	motif 1; other site
76869010804	motif 3; other site
76869010805	motif 2; other site
76869010806	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
76869010807	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
76869010808	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
76869010809	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
76869010810	dimer interface [polypeptide binding]; other site
76869010811	motif 1; other site
76869010812	active site
76869010813	motif 2; other site
76869010814	motif 3; other site
76869010815	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
76869010816	23S rRNA binding site [nucleotide binding]; other site
76869010817	L21 binding site [polypeptide binding]; other site
76869010818	L13 binding site [polypeptide binding]; other site
76869010819	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
76869010820	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
76869010821	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
76869010822	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
76869010823	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
76869010824	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
76869010825	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
76869010826	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
76869010827	active site
76869010828	dimer interface [polypeptide binding]; other site
76869010829	motif 1; other site
76869010830	motif 2; other site
76869010831	motif 3; other site
76869010832	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
76869010833	anticodon binding site; other site
76869010834	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
76869010835	DNA-binding site [nucleotide binding]; DNA binding site
76869010836	RNA-binding motif; other site
76869010837	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
76869010838	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
76869010839	active site
76869010840	tetramer interface [polypeptide binding]; other site
76869010841	D-ribose pyranase; Provisional; Region: PRK11797
76869010842	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
76869010843	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
76869010844	substrate binding site [chemical binding]; other site
76869010845	dimer interface [polypeptide binding]; other site
76869010846	ATP binding site [chemical binding]; other site
76869010847	Transcriptional regulators [Transcription]; Region: PurR; COG1609
76869010848	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
76869010849	DNA binding site [nucleotide binding]
76869010850	domain linker motif; other site
76869010851	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
76869010852	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
76869010853	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
76869010854	TM-ABC transporter signature motif; other site
76869010855	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
76869010856	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
76869010857	Walker A/P-loop; other site
76869010858	ATP binding site [chemical binding]; other site
76869010859	Q-loop/lid; other site
76869010860	ABC transporter signature motif; other site
76869010861	Walker B; other site
76869010862	D-loop; other site
76869010863	H-loop/switch region; other site
76869010864	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
76869010865	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
76869010866	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
76869010867	ligand binding site [chemical binding]; other site
76869010868	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
76869010869	homodimer interface [polypeptide binding]; other site
76869010870	active site
76869010871	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
76869010872	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869010873	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
76869010874	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869010875	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869010876	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
76869010877	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
76869010878	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
76869010879	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
76869010880	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
76869010881	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
76869010882	NAD binding site [chemical binding]; other site
76869010883	catalytic residues [active]
76869010884	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
76869010885	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
76869010886	putative active site [active]
76869010887	putative metal binding site [ion binding]; other site
76869010888	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
76869010889	putative substrate binding pocket [chemical binding]; other site
76869010890	trimer interface [polypeptide binding]; other site
76869010891	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
76869010892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010894	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
76869010895	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
76869010896	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
76869010897	Transcriptional regulators [Transcription]; Region: MarR; COG1846
76869010898	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869010899	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
76869010900	Flavin binding site [chemical binding]; other site
76869010901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869010902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869010903	MarR family; Region: MarR_2; cl17246
76869010904	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869010905	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869010906	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869010907	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
76869010908	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
76869010909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869010910	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
76869010911	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869010912	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869010913	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869010914	NAD(P) binding site [chemical binding]; other site
76869010915	catalytic residues [active]
76869010916	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
76869010917	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
76869010918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869010919	ornithine cyclodeaminase; Validated; Region: PRK06199
76869010920	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
76869010921	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
76869010922	homotrimer interaction site [polypeptide binding]; other site
76869010923	putative active site [active]
76869010924	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869010925	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869010926	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869010927	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869010928	N-terminal plug; other site
76869010929	ligand-binding site [chemical binding]; other site
76869010930	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
76869010931	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
76869010932	DNA-specific endonuclease I; Provisional; Region: PRK15137
76869010933	HD domain; Region: HD_4; pfam13328
76869010934	Sporulation related domain; Region: SPOR; pfam05036
76869010935	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869010936	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869010937	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
76869010938	putative active site [active]
76869010939	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
76869010940	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
76869010941	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869010942	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
76869010943	putative dimerization interface [polypeptide binding]; other site
76869010944	serine/threonine transporter SstT; Provisional; Region: PRK13628
76869010945	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
76869010946	Protein of unknown function, DUF480; Region: DUF480; pfam04337
76869010947	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
76869010948	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
76869010949	catalytic residue [active]
76869010950	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
76869010951	catalytic residues [active]
76869010952	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869010953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869010954	peroxiredoxin; Region: AhpC; TIGR03137
76869010955	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
76869010956	dimer interface [polypeptide binding]; other site
76869010957	decamer (pentamer of dimers) interface [polypeptide binding]; other site
76869010958	catalytic triad [active]
76869010959	peroxidatic and resolving cysteines [active]
76869010960	glutathione reductase; Validated; Region: PRK06116
76869010961	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869010962	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869010963	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
76869010964	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
76869010965	active site
76869010966	tetramer interface; other site
76869010967	Cytochrome c [Energy production and conversion]; Region: COG3258
76869010968	Cytochrome c; Region: Cytochrom_C; pfam00034
76869010969	Cytochrome c553 [Energy production and conversion]; Region: COG2863
76869010970	Cytochrome c; Region: Cytochrom_C; cl11414
76869010971	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
76869010972	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
76869010973	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
76869010974	FMN binding site [chemical binding]; other site
76869010975	substrate binding site [chemical binding]; other site
76869010976	putative catalytic residue [active]
76869010977	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
76869010978	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869010979	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
76869010980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869010981	dimer interface [polypeptide binding]; other site
76869010982	conserved gate region; other site
76869010983	putative PBP binding loops; other site
76869010984	ABC-ATPase subunit interface; other site
76869010985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869010986	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
76869010987	Walker A/P-loop; other site
76869010988	ATP binding site [chemical binding]; other site
76869010989	Q-loop/lid; other site
76869010990	ABC transporter signature motif; other site
76869010991	Walker B; other site
76869010992	D-loop; other site
76869010993	H-loop/switch region; other site
76869010994	TOBE domain; Region: TOBE; cl01440
76869010995	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
76869010996	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
76869010997	active site
76869010998	DNA binding site [nucleotide binding]
76869010999	Int/Topo IB signature motif; other site
76869011000	catalytic residues [active]
76869011001	carbon storage regulator; Provisional; Region: PRK01712
76869011002	Response regulator receiver domain; Region: Response_reg; pfam00072
76869011003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869011004	active site
76869011005	phosphorylation site [posttranslational modification]
76869011006	intermolecular recognition site; other site
76869011007	dimerization interface [polypeptide binding]; other site
76869011008	circadian clock protein KaiC; Reviewed; Region: PRK09302
76869011009	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
76869011010	Walker A motif; other site
76869011011	ATP binding site [chemical binding]; other site
76869011012	Walker B motif; other site
76869011013	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
76869011014	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
76869011015	Walker A motif; other site
76869011016	Walker A motif; other site
76869011017	ATP binding site [chemical binding]; other site
76869011018	Walker B motif; other site
76869011019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869011020	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
76869011021	putative active site [active]
76869011022	heme pocket [chemical binding]; other site
76869011023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869011024	dimer interface [polypeptide binding]; other site
76869011025	phosphorylation site [posttranslational modification]
76869011026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869011027	ATP binding site [chemical binding]; other site
76869011028	Mg2+ binding site [ion binding]; other site
76869011029	G-X-G motif; other site
76869011030	Predicted membrane protein [Function unknown]; Region: COG2259
76869011031	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
76869011032	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
76869011033	NAD binding site [chemical binding]; other site
76869011034	substrate binding site [chemical binding]; other site
76869011035	catalytic Zn binding site [ion binding]; other site
76869011036	tetramer interface [polypeptide binding]; other site
76869011037	structural Zn binding site [ion binding]; other site
76869011038	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
76869011039	putative inner membrane peptidase; Provisional; Region: PRK11778
76869011040	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
76869011041	tandem repeat interface [polypeptide binding]; other site
76869011042	oligomer interface [polypeptide binding]; other site
76869011043	active site residues [active]
76869011044	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
76869011045	catalytic core [active]
76869011046	SCP-2 sterol transfer family; Region: SCP2; pfam02036
76869011047	Phosphotransferase enzyme family; Region: APH; pfam01636
76869011048	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
76869011049	putative active site [active]
76869011050	putative substrate binding site [chemical binding]; other site
76869011051	ATP binding site [chemical binding]; other site
76869011052	short chain dehydrogenase; Provisional; Region: PRK07035
76869011053	classical (c) SDRs; Region: SDR_c; cd05233
76869011054	NAD(P) binding site [chemical binding]; other site
76869011055	active site
76869011056	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869011057	S-adenosylmethionine binding site [chemical binding]; other site
76869011058	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869011059	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869011060	metal binding site [ion binding]; metal-binding site
76869011061	active site
76869011062	I-site; other site
76869011063	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
76869011064	transmembrane helices; other site
76869011065	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
76869011066	TrkA-C domain; Region: TrkA_C; pfam02080
76869011067	TrkA-C domain; Region: TrkA_C; pfam02080
76869011068	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
76869011069	transmembrane helices; other site
76869011070	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869011071	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869011072	metal binding site [ion binding]; metal-binding site
76869011073	active site
76869011074	I-site; other site
76869011075	hypothetical protein; Provisional; Region: PRK10621
76869011076	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869011077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869011078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869011079	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869011080	putative effector binding pocket; other site
76869011081	dimerization interface [polypeptide binding]; other site
76869011082	similar to hypothetical protein
76869011083	Src Homology 3 domain superfamily; Region: SH3; cl17036
76869011084	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869011085	outer membrane porin, OprD family; Region: OprD; pfam03573
76869011086	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
76869011087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869011088	putative substrate translocation pore; other site
76869011089	Isochorismatase family; Region: Isochorismatase; pfam00857
76869011090	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
76869011091	catalytic triad [active]
76869011092	substrate binding site [chemical binding]; other site
76869011093	domain interfaces; other site
76869011094	conserved cis-peptide bond; other site
76869011095	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
76869011096	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869011097	hypothetical protein; Provisional; Region: PRK06847
76869011098	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
76869011099	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
76869011100	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869011101	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
76869011102	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
76869011103	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
76869011104	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
76869011105	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
76869011106	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869011107	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
76869011108	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
76869011109	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869011110	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869011111	Cytochrome c; Region: Cytochrom_C; pfam00034
76869011112	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869011113	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869011114	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869011115	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
76869011116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869011117	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
76869011118	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
76869011119	XdhC Rossmann domain; Region: XdhC_C; pfam13478
76869011120	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
76869011121	benzoate transport; Region: 2A0115; TIGR00895
76869011122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869011123	putative substrate translocation pore; other site
76869011124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869011125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869011126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869011127	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
76869011128	substrate binding pocket [chemical binding]; other site
76869011129	dimerization interface [polypeptide binding]; other site
76869011130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
76869011131	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869011132	cytosine deaminase; Provisional; Region: PRK05985
76869011133	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
76869011134	active site
76869011135	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
76869011136	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869011137	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869011138	dimerization interface [polypeptide binding]; other site
76869011139	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869011140	Coenzyme A binding pocket [chemical binding]; other site
76869011141	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
76869011142	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
76869011143	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
76869011144	YccA-like proteins; Region: YccA_like; cd10433
76869011145	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
76869011146	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
76869011147	sulfur relay protein TusC; Validated; Region: PRK00211
76869011148	DsrH like protein; Region: DsrH; cl17347
76869011149	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
76869011150	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
76869011151	hypothetical protein; Validated; Region: PRK09071
76869011152	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
76869011153	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
76869011154	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
76869011155	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
76869011156	putative dimer interface [polypeptide binding]; other site
76869011157	N-terminal domain interface [polypeptide binding]; other site
76869011158	putative substrate binding pocket (H-site) [chemical binding]; other site
76869011159	siroheme synthase; Provisional; Region: cysG; PRK10637
76869011160	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
76869011161	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
76869011162	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
76869011163	active site
76869011164	SAM binding site [chemical binding]; other site
76869011165	homodimer interface [polypeptide binding]; other site
76869011166	seryl-tRNA synthetase; Provisional; Region: PRK05431
76869011167	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
76869011168	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
76869011169	dimer interface [polypeptide binding]; other site
76869011170	active site
76869011171	motif 1; other site
76869011172	motif 2; other site
76869011173	motif 3; other site
76869011174	camphor resistance protein CrcB; Provisional; Region: PRK14234
76869011175	recombination factor protein RarA; Reviewed; Region: PRK13342
76869011176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869011177	Walker A motif; other site
76869011178	ATP binding site [chemical binding]; other site
76869011179	Walker B motif; other site
76869011180	arginine finger; other site
76869011181	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
76869011182	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
76869011183	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
76869011184	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
76869011185	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
76869011186	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
76869011187	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
76869011188	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
76869011189	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
76869011190	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
76869011191	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
76869011192	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
76869011193	rRNA binding site [nucleotide binding]; other site
76869011194	predicted 30S ribosome binding site; other site
76869011195	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
76869011196	Clp amino terminal domain; Region: Clp_N; pfam02861
76869011197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869011198	Walker A motif; other site
76869011199	ATP binding site [chemical binding]; other site
76869011200	Walker B motif; other site
76869011201	arginine finger; other site
76869011202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869011203	Walker A motif; other site
76869011204	ATP binding site [chemical binding]; other site
76869011205	Walker B motif; other site
76869011206	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
76869011207	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
76869011208	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
76869011209	DNA-binding site [nucleotide binding]; DNA binding site
76869011210	RNA-binding motif; other site
76869011211	isocitrate dehydrogenase; Validated; Region: PRK07362
76869011212	isocitrate dehydrogenase; Reviewed; Region: PRK07006
76869011213	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
76869011214	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
76869011215	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
76869011216	nudix motif; other site
76869011217	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
76869011218	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
76869011219	putative lysogenization regulator; Reviewed; Region: PRK00218
76869011220	adenylosuccinate lyase; Provisional; Region: PRK09285
76869011221	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
76869011222	tetramer interface [polypeptide binding]; other site
76869011223	active site
76869011224	Uncharacterized conserved protein [Function unknown]; Region: COG2850
76869011225	Cupin domain; Region: Cupin_2; cl17218
76869011226	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
76869011227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869011228	Coenzyme A binding pocket [chemical binding]; other site
76869011229	DNA topoisomerase III; Provisional; Region: PRK07726
76869011230	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
76869011231	active site
76869011232	putative interdomain interaction site [polypeptide binding]; other site
76869011233	putative metal-binding site [ion binding]; other site
76869011234	putative nucleotide binding site [chemical binding]; other site
76869011235	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
76869011236	domain I; other site
76869011237	DNA binding groove [nucleotide binding]
76869011238	phosphate binding site [ion binding]; other site
76869011239	domain II; other site
76869011240	domain III; other site
76869011241	nucleotide binding site [chemical binding]; other site
76869011242	catalytic site [active]
76869011243	domain IV; other site
76869011244	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869011245	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869011246	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869011247	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869011248	hypothetical protein; Provisional; Region: PRK10621
76869011249	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869011250	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
76869011251	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
76869011252	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
76869011253	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
76869011254	putative NADH binding site [chemical binding]; other site
76869011255	putative active site [active]
76869011256	nudix motif; other site
76869011257	putative metal binding site [ion binding]; other site
76869011258	enoyl-CoA hydratase; Provisional; Region: PRK06142
76869011259	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869011260	substrate binding site [chemical binding]; other site
76869011261	oxyanion hole (OAH) forming residues; other site
76869011262	trimer interface [polypeptide binding]; other site
76869011263	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
76869011264	RibD C-terminal domain; Region: RibD_C; cl17279
76869011265	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
76869011266	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
76869011267	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
76869011268	nudix motif; other site
76869011269	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
76869011270	AAA domain; Region: AAA_17; pfam13207
76869011271	allantoate amidohydrolase; Reviewed; Region: PRK12893
76869011272	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
76869011273	active site
76869011274	metal binding site [ion binding]; metal-binding site
76869011275	dimer interface [polypeptide binding]; other site
76869011276	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
76869011277	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869011278	Na binding site [ion binding]; other site
76869011279	putative substrate binding site [chemical binding]; other site
76869011280	phenylhydantoinase; Validated; Region: PRK08323
76869011281	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
76869011282	tetramer interface [polypeptide binding]; other site
76869011283	active site
76869011284	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
76869011285	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
76869011286	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869011287	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869011288	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
76869011289	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
76869011290	homodimer interface [polypeptide binding]; other site
76869011291	active site
76869011292	FMN binding site [chemical binding]; other site
76869011293	substrate binding site [chemical binding]; other site
76869011294	4Fe-4S binding domain; Region: Fer4; cl02805
76869011295	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
76869011296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869011297	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
76869011298	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869011299	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
76869011300	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
76869011301	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869011302	non-specific DNA binding site [nucleotide binding]; other site
76869011303	salt bridge; other site
76869011304	sequence-specific DNA binding site [nucleotide binding]; other site
76869011305	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
76869011306	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
76869011307	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
76869011308	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
76869011309	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
76869011310	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
76869011311	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
76869011312	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
76869011313	glycogen synthase; Provisional; Region: glgA; PRK00654
76869011314	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
76869011315	ADP-binding pocket [chemical binding]; other site
76869011316	homodimer interface [polypeptide binding]; other site
76869011317	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
76869011318	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
76869011319	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
76869011320	catalytic site [active]
76869011321	active site
76869011322	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
76869011323	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
76869011324	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
76869011325	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
76869011326	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
76869011327	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
76869011328	active site
76869011329	catalytic site [active]
76869011330	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
76869011331	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
76869011332	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
76869011333	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
76869011334	active site
76869011335	catalytic site [active]
76869011336	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
76869011337	putative catalytic site [active]
76869011338	putative metal binding site [ion binding]; other site
76869011339	putative phosphate binding site [ion binding]; other site
76869011340	Autotransporter beta-domain; Region: Autotransporter; pfam03797
76869011341	glycogen branching enzyme; Provisional; Region: PRK05402
76869011342	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
76869011343	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
76869011344	active site
76869011345	catalytic site [active]
76869011346	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
76869011347	trehalose synthase; Region: treS_nterm; TIGR02456
76869011348	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
76869011349	active site
76869011350	catalytic site [active]
76869011351	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
76869011352	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
76869011353	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
76869011354	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
76869011355	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
76869011356	active site
76869011357	homodimer interface [polypeptide binding]; other site
76869011358	catalytic site [active]
76869011359	acceptor binding site [chemical binding]; other site
76869011360	AMP-binding domain protein; Validated; Region: PRK08315
76869011361	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
76869011362	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
76869011363	acyl-activating enzyme (AAE) consensus motif; other site
76869011364	putative AMP binding site [chemical binding]; other site
76869011365	putative active site [active]
76869011366	putative CoA binding site [chemical binding]; other site
76869011367	isovaleryl-CoA dehydrogenase; Region: PLN02519
76869011368	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
76869011369	substrate binding site [chemical binding]; other site
76869011370	FAD binding site [chemical binding]; other site
76869011371	catalytic base [active]
76869011372	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
76869011373	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
76869011374	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
76869011375	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
76869011376	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869011377	substrate binding site [chemical binding]; other site
76869011378	oxyanion hole (OAH) forming residues; other site
76869011379	trimer interface [polypeptide binding]; other site
76869011380	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
76869011381	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
76869011382	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
76869011383	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
76869011384	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
76869011385	carboxyltransferase (CT) interaction site; other site
76869011386	biotinylation site [posttranslational modification]; other site
76869011387	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
76869011388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869011389	non-specific DNA binding site [nucleotide binding]; other site
76869011390	salt bridge; other site
76869011391	sequence-specific DNA binding site [nucleotide binding]; other site
76869011392	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
76869011393	Catalytic site [active]
76869011394	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
76869011395	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869011396	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
76869011397	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
76869011398	transmembrane helices; other site
76869011399	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
76869011400	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
76869011401	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
76869011402	active site
76869011403	catalytic site [active]
76869011404	putative DNA binding site [nucleotide binding]; other site
76869011405	GIY-YIG motif/motif A; other site
76869011406	metal binding site [ion binding]; metal-binding site
76869011407	UvrB/uvrC motif; Region: UVR; pfam02151
76869011408	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
76869011409	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
76869011410	DNA binding site [nucleotide binding]
76869011411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869011412	Response regulator receiver domain; Region: Response_reg; pfam00072
76869011413	active site
76869011414	phosphorylation site [posttranslational modification]
76869011415	intermolecular recognition site; other site
76869011416	dimerization interface [polypeptide binding]; other site
76869011417	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
76869011418	DNA binding residues [nucleotide binding]
76869011419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
76869011420	sequence-specific DNA binding site [nucleotide binding]; other site
76869011421	salt bridge; other site
76869011422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869011423	Coenzyme A binding pocket [chemical binding]; other site
76869011424	Uncharacterized conserved protein [Function unknown]; Region: COG3189
76869011425	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
76869011426	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
76869011427	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869011428	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
76869011429	C-terminal domain interface [polypeptide binding]; other site
76869011430	GSH binding site (G-site) [chemical binding]; other site
76869011431	dimer interface [polypeptide binding]; other site
76869011432	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
76869011433	dimer interface [polypeptide binding]; other site
76869011434	N-terminal domain interface [polypeptide binding]; other site
76869011435	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
76869011436	CoenzymeA binding site [chemical binding]; other site
76869011437	subunit interaction site [polypeptide binding]; other site
76869011438	PHB binding site; other site
76869011439	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
76869011440	Spore germination protein; Region: Spore_permease; cl17796
76869011441	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869011442	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869011443	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869011444	dimerization interface [polypeptide binding]; other site
76869011445	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
76869011446	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869011447	inhibitor-cofactor binding pocket; inhibition site
76869011448	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869011449	catalytic residue [active]
76869011450	elongation factor G; Reviewed; Region: PRK00007
76869011451	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
76869011452	G1 box; other site
76869011453	putative GEF interaction site [polypeptide binding]; other site
76869011454	GTP/Mg2+ binding site [chemical binding]; other site
76869011455	Switch I region; other site
76869011456	G2 box; other site
76869011457	G3 box; other site
76869011458	Switch II region; other site
76869011459	G4 box; other site
76869011460	G5 box; other site
76869011461	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
76869011462	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
76869011463	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
76869011464	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
76869011465	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
76869011466	Sulfate transporter family; Region: Sulfate_transp; pfam00916
76869011467	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
76869011468	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
76869011469	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
76869011470	isocitrate lyase; Provisional; Region: PRK15063
76869011471	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
76869011472	tetramer interface [polypeptide binding]; other site
76869011473	active site
76869011474	Mg2+/Mn2+ binding site [ion binding]; other site
76869011475	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
76869011476	YhhN-like protein; Region: YhhN; pfam07947
76869011477	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
76869011478	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
76869011479	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
76869011480	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
76869011481	NADH dehydrogenase subunit D; Validated; Region: PRK06075
76869011482	NADH dehydrogenase subunit E; Validated; Region: PRK07539
76869011483	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
76869011484	putative dimer interface [polypeptide binding]; other site
76869011485	[2Fe-2S] cluster binding site [ion binding]; other site
76869011486	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
76869011487	SLBB domain; Region: SLBB; pfam10531
76869011488	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
76869011489	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
76869011490	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869011491	catalytic loop [active]
76869011492	iron binding site [ion binding]; other site
76869011493	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
76869011494	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
76869011495	[4Fe-4S] binding site [ion binding]; other site
76869011496	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
76869011497	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
76869011498	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
76869011499	4Fe-4S binding domain; Region: Fer4; pfam00037
76869011500	4Fe-4S binding domain; Region: Fer4; pfam00037
76869011501	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
76869011502	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
76869011503	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
76869011504	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
76869011505	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
76869011506	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
76869011507	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
76869011508	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
76869011509	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
76869011510	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
76869011511	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
76869011512	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
76869011513	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869011514	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869011515	DNA binding residues [nucleotide binding]
76869011516	dimerization interface [polypeptide binding]; other site
76869011517	Predicted flavoprotein [General function prediction only]; Region: COG0431
76869011518	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869011519	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
76869011520	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
76869011521	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
76869011522	homodimer interface [polypeptide binding]; other site
76869011523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869011524	catalytic residue [active]
76869011525	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
76869011526	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
76869011527	active site
76869011528	catalytic site [active]
76869011529	substrate binding site [chemical binding]; other site
76869011530	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
76869011531	RNA/DNA hybrid binding site [nucleotide binding]; other site
76869011532	active site
76869011533	Methyltransferase domain; Region: Methyltransf_23; pfam13489
76869011534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
76869011535	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
76869011536	MltD lipid attachment motif; Region: MLTD_N; pfam06474
76869011537	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
76869011538	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869011539	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869011540	catalytic residue [active]
76869011541	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
76869011542	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
76869011543	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
76869011544	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
76869011545	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
76869011546	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
76869011547	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
76869011548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869011549	dimer interface [polypeptide binding]; other site
76869011550	conserved gate region; other site
76869011551	putative PBP binding loops; other site
76869011552	ABC-ATPase subunit interface; other site
76869011553	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
76869011554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869011555	dimer interface [polypeptide binding]; other site
76869011556	conserved gate region; other site
76869011557	putative PBP binding loops; other site
76869011558	ABC-ATPase subunit interface; other site
76869011559	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
76869011560	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869011561	Walker A/P-loop; other site
76869011562	ATP binding site [chemical binding]; other site
76869011563	Q-loop/lid; other site
76869011564	ABC transporter signature motif; other site
76869011565	Walker B; other site
76869011566	D-loop; other site
76869011567	H-loop/switch region; other site
76869011568	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
76869011569	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
76869011570	Walker A/P-loop; other site
76869011571	ATP binding site [chemical binding]; other site
76869011572	Q-loop/lid; other site
76869011573	ABC transporter signature motif; other site
76869011574	Walker B; other site
76869011575	D-loop; other site
76869011576	H-loop/switch region; other site
76869011577	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
76869011578	HD domain; Region: HD_3; pfam13023
76869011579	hypothetical protein; Provisional; Region: PRK06149
76869011580	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
76869011581	active site
76869011582	ATP binding site [chemical binding]; other site
76869011583	substrate binding site [chemical binding]; other site
76869011584	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869011585	inhibitor-cofactor binding pocket; inhibition site
76869011586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869011587	catalytic residue [active]
76869011588	probable polyamine oxidase; Region: PLN02268
76869011589	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869011590	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869011591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869011592	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869011593	dimerization interface [polypeptide binding]; other site
76869011594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869011595	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
76869011596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869011597	active site
76869011598	phosphorylation site [posttranslational modification]
76869011599	intermolecular recognition site; other site
76869011600	dimerization interface [polypeptide binding]; other site
76869011601	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869011602	DNA binding site [nucleotide binding]
76869011603	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
76869011604	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
76869011605	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
76869011606	Ligand Binding Site [chemical binding]; other site
76869011607	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
76869011608	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869011609	dimer interface [polypeptide binding]; other site
76869011610	phosphorylation site [posttranslational modification]
76869011611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869011612	ATP binding site [chemical binding]; other site
76869011613	Mg2+ binding site [ion binding]; other site
76869011614	G-X-G motif; other site
76869011615	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
76869011616	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
76869011617	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869011618	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
76869011619	Soluble P-type ATPase [General function prediction only]; Region: COG4087
76869011620	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
76869011621	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
76869011622	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869011623	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
76869011624	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
76869011625	catalytic core [active]
76869011626	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
76869011627	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
76869011628	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
76869011629	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
76869011630	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
76869011631	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
76869011632	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
76869011633	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869011634	dimerization interface [polypeptide binding]; other site
76869011635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869011636	dimer interface [polypeptide binding]; other site
76869011637	phosphorylation site [posttranslational modification]
76869011638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869011639	ATP binding site [chemical binding]; other site
76869011640	Mg2+ binding site [ion binding]; other site
76869011641	G-X-G motif; other site
76869011642	Response regulator receiver domain; Region: Response_reg; pfam00072
76869011643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869011644	active site
76869011645	phosphorylation site [posttranslational modification]
76869011646	intermolecular recognition site; other site
76869011647	dimerization interface [polypeptide binding]; other site
76869011648	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
76869011649	active site 1 [active]
76869011650	dimer interface [polypeptide binding]; other site
76869011651	active site 2 [active]
76869011652	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
76869011653	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
76869011654	dimer interface [polypeptide binding]; other site
76869011655	active site
76869011656	Amidohydrolase; Region: Amidohydro_2; pfam04909
76869011657	Pirin-related protein [General function prediction only]; Region: COG1741
76869011658	Pirin; Region: Pirin; pfam02678
76869011659	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
76869011660	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
76869011661	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869011662	heat shock protein 90; Provisional; Region: PRK05218
76869011663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869011664	ATP binding site [chemical binding]; other site
76869011665	Mg2+ binding site [ion binding]; other site
76869011666	G-X-G motif; other site
76869011667	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
76869011668	CoenzymeA binding site [chemical binding]; other site
76869011669	subunit interaction site [polypeptide binding]; other site
76869011670	PHB binding site; other site
76869011671	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
76869011672	CoenzymeA binding site [chemical binding]; other site
76869011673	subunit interaction site [polypeptide binding]; other site
76869011674	PHB binding site; other site
76869011675	Predicted membrane protein [Function unknown]; Region: COG3821
76869011676	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
76869011677	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
76869011678	CoA binding domain; Region: CoA_binding; pfam02629
76869011679	CoA-ligase; Region: Ligase_CoA; pfam00549
76869011680	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
76869011681	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
76869011682	CoA-ligase; Region: Ligase_CoA; pfam00549
76869011683	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
76869011684	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
76869011685	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869011686	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
76869011687	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
76869011688	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869011689	E3 interaction surface; other site
76869011690	lipoyl attachment site [posttranslational modification]; other site
76869011691	e3 binding domain; Region: E3_binding; pfam02817
76869011692	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
76869011693	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
76869011694	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
76869011695	TPP-binding site [chemical binding]; other site
76869011696	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
76869011697	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
76869011698	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
76869011699	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
76869011700	L-aspartate oxidase; Provisional; Region: PRK06175
76869011701	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
76869011702	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
76869011703	SdhC subunit interface [polypeptide binding]; other site
76869011704	proximal heme binding site [chemical binding]; other site
76869011705	cardiolipin binding site; other site
76869011706	Iron-sulfur protein interface; other site
76869011707	proximal quinone binding site [chemical binding]; other site
76869011708	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
76869011709	Iron-sulfur protein interface; other site
76869011710	proximal quinone binding site [chemical binding]; other site
76869011711	SdhD (CybS) interface [polypeptide binding]; other site
76869011712	proximal heme binding site [chemical binding]; other site
76869011713	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
76869011714	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
76869011715	dimer interface [polypeptide binding]; other site
76869011716	active site
76869011717	citrylCoA binding site [chemical binding]; other site
76869011718	NADH binding [chemical binding]; other site
76869011719	cationic pore residues; other site
76869011720	oxalacetate/citrate binding site [chemical binding]; other site
76869011721	coenzyme A binding site [chemical binding]; other site
76869011722	catalytic triad [active]
76869011723	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
76869011724	putative lipid binding site [chemical binding]; other site
76869011725	Protein of unknown function (DUF3233); Region: DUF3233; pfam11557
76869011726	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869011727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869011728	DNA-binding site [nucleotide binding]; DNA binding site
76869011729	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869011730	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869011731	homodimer interface [polypeptide binding]; other site
76869011732	catalytic residue [active]
76869011733	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869011734	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869011735	ligand binding site [chemical binding]; other site
76869011736	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
76869011737	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869011738	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869011739	substrate binding pocket [chemical binding]; other site
76869011740	membrane-bound complex binding site; other site
76869011741	hinge residues; other site
76869011742	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
76869011743	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
76869011744	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
76869011745	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
76869011746	Ligand binding site [chemical binding]; other site
76869011747	Electron transfer flavoprotein domain; Region: ETF; pfam01012
76869011748	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
76869011749	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869011750	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
76869011751	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
76869011752	toxin interface [polypeptide binding]; other site
76869011753	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
76869011754	Zn binding site [ion binding]; other site
76869011755	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
76869011756	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
76869011757	peptide binding site [polypeptide binding]; other site
76869011758	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869011759	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
76869011760	RNA polymerase sigma factor; Reviewed; Region: PRK12527
76869011761	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869011762	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869011763	DNA binding residues [nucleotide binding]
76869011764	macrolide transporter subunit MacA; Provisional; Region: PRK11578
76869011765	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869011766	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869011767	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
76869011768	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
76869011769	Walker A/P-loop; other site
76869011770	ATP binding site [chemical binding]; other site
76869011771	Q-loop/lid; other site
76869011772	ABC transporter signature motif; other site
76869011773	Walker B; other site
76869011774	D-loop; other site
76869011775	H-loop/switch region; other site
76869011776	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
76869011777	FtsX-like permease family; Region: FtsX; pfam02687
76869011778	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
76869011779	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
76869011780	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
76869011781	active site
76869011782	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
76869011783	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
76869011784	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869011785	catalytic residue [active]
76869011786	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
76869011787	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
76869011788	substrate binding pocket [chemical binding]; other site
76869011789	SCP-2 sterol transfer family; Region: SCP2; pfam02036
76869011790	Cupin-like domain; Region: Cupin_8; pfam13621
76869011791	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
76869011792	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
76869011793	FAD binding pocket [chemical binding]; other site
76869011794	FAD binding motif [chemical binding]; other site
76869011795	phosphate binding motif [ion binding]; other site
76869011796	NAD binding pocket [chemical binding]; other site
76869011797	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
76869011798	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869011799	inhibitor-cofactor binding pocket; inhibition site
76869011800	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869011801	catalytic residue [active]
76869011802	sensor protein QseC; Provisional; Region: PRK10337
76869011803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869011804	dimer interface [polypeptide binding]; other site
76869011805	phosphorylation site [posttranslational modification]
76869011806	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869011807	ATP binding site [chemical binding]; other site
76869011808	G-X-G motif; other site
76869011809	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869011810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869011811	active site
76869011812	phosphorylation site [posttranslational modification]
76869011813	intermolecular recognition site; other site
76869011814	dimerization interface [polypeptide binding]; other site
76869011815	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869011816	DNA binding site [nucleotide binding]
76869011817	GAD-like domain; Region: GAD-like; pfam08887
76869011818	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
76869011819	GAD-like domain; Region: GAD-like; pfam08887
76869011820	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
76869011821	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
76869011822	Ligand binding site; other site
76869011823	metal-binding site
76869011824	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
76869011825	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
76869011826	XdhC Rossmann domain; Region: XdhC_C; pfam13478
76869011827	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869011828	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
76869011829	Cytochrome c; Region: Cytochrom_C; pfam00034
76869011830	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
76869011831	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
76869011832	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
76869011833	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
76869011834	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869011835	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869011836	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
76869011837	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
76869011838	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
76869011839	DsbD alpha interface [polypeptide binding]; other site
76869011840	catalytic residues [active]
76869011841	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
76869011842	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
76869011843	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869011844	catalytic residues [active]
76869011845	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
76869011846	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
76869011847	dimerization domain [polypeptide binding]; other site
76869011848	dimer interface [polypeptide binding]; other site
76869011849	catalytic residues [active]
76869011850	peptide synthase; Validated; Region: PRK05691
76869011851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
76869011852	Transposase; Region: HTH_Tnp_1; pfam01527
76869011853	putative transposase OrfB; Reviewed; Region: PHA02517
76869011854	HTH-like domain; Region: HTH_21; pfam13276
76869011855	Integrase core domain; Region: rve; pfam00665
76869011856	Integrase core domain; Region: rve_2; pfam13333
76869011857	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
76869011858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
76869011859	Walker A/P-loop; other site
76869011860	ATP binding site [chemical binding]; other site
76869011861	Q-loop/lid; other site
76869011862	ABC transporter signature motif; other site
76869011863	Walker B; other site
76869011864	D-loop; other site
76869011865	H-loop/switch region; other site
76869011866	peptide synthase; Validated; Region: PRK05691
76869011867	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
76869011868	acyl-activating enzyme (AAE) consensus motif; other site
76869011869	active site
76869011870	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869011871	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869011872	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869011873	acyl-activating enzyme (AAE) consensus motif; other site
76869011874	AMP binding site [chemical binding]; other site
76869011875	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869011876	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869011877	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869011878	acyl-activating enzyme (AAE) consensus motif; other site
76869011879	AMP binding site [chemical binding]; other site
76869011880	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869011881	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
76869011882	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869011883	acyl-activating enzyme (AAE) consensus motif; other site
76869011884	AMP binding site [chemical binding]; other site
76869011885	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869011886	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
76869011887	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869011888	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869011889	DNA binding residues [nucleotide binding]
76869011890	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
76869011891	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
76869011892	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869011893	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869011894	substrate binding pocket [chemical binding]; other site
76869011895	membrane-bound complex binding site; other site
76869011896	hinge residues; other site
76869011897	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
76869011898	active site
76869011899	catalytic site [active]
76869011900	substrate binding site [chemical binding]; other site
76869011901	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
76869011902	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
76869011903	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
76869011904	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
76869011905	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
76869011906	Low-spin heme binding site [chemical binding]; other site
76869011907	Putative water exit pathway; other site
76869011908	Binuclear center (active site) [active]
76869011909	Putative proton exit pathway; other site
76869011910	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
76869011911	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
76869011912	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
76869011913	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
76869011914	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869011915	Cytochrome c; Region: Cytochrom_C; pfam00034
76869011916	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
76869011917	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
76869011918	Low-spin heme binding site [chemical binding]; other site
76869011919	Putative water exit pathway; other site
76869011920	Binuclear center (active site) [active]
76869011921	Putative proton exit pathway; other site
76869011922	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
76869011923	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
76869011924	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
76869011925	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
76869011926	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
76869011927	Cytochrome c; Region: Cytochrom_C; pfam00034
76869011928	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
76869011929	4Fe-4S binding domain; Region: Fer4_5; pfam12801
76869011930	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
76869011931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
76869011932	FixH; Region: FixH; pfam05751
76869011933	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
76869011934	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
76869011935	Heavy-metal-associated domain; Region: HMA; pfam00403
76869011936	metal-binding site [ion binding]
76869011937	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869011938	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
76869011939	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
76869011940	Uncharacterized conserved protein [Function unknown]; Region: COG2836
76869011941	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
76869011942	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869011943	FeS/SAM binding site; other site
76869011944	HemN C-terminal domain; Region: HemN_C; pfam06969
76869011945	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
76869011946	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
76869011947	ligand binding site [chemical binding]; other site
76869011948	flexible hinge region; other site
76869011949	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
76869011950	putative switch regulator; other site
76869011951	non-specific DNA interactions [nucleotide binding]; other site
76869011952	DNA binding site [nucleotide binding]
76869011953	sequence specific DNA binding site [nucleotide binding]; other site
76869011954	putative cAMP binding site [chemical binding]; other site
76869011955	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869011956	active site
76869011957	recombination protein RecR; Reviewed; Region: recR; PRK00076
76869011958	RecR protein; Region: RecR; pfam02132
76869011959	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
76869011960	putative active site [active]
76869011961	putative metal-binding site [ion binding]; other site
76869011962	tetramer interface [polypeptide binding]; other site
76869011963	hypothetical protein; Validated; Region: PRK00153
76869011964	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
76869011965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869011966	Walker A motif; other site
76869011967	ATP binding site [chemical binding]; other site
76869011968	Walker B motif; other site
76869011969	arginine finger; other site
76869011970	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
76869011971	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869011972	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869011973	substrate binding pocket [chemical binding]; other site
76869011974	membrane-bound complex binding site; other site
76869011975	hinge residues; other site
76869011976	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
76869011977	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
76869011978	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
76869011979	DNA binding residues [nucleotide binding]
76869011980	putative dimer interface [polypeptide binding]; other site
76869011981	putative metal binding residues [ion binding]; other site
76869011982	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
76869011983	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
76869011984	nucleotide binding pocket [chemical binding]; other site
76869011985	K-X-D-G motif; other site
76869011986	catalytic site [active]
76869011987	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
76869011988	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
76869011989	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
76869011990	Dimer interface [polypeptide binding]; other site
76869011991	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
76869011992	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
76869011993	FtsZ protein binding site [polypeptide binding]; other site
76869011994	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
76869011995	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
76869011996	Walker A/P-loop; other site
76869011997	ATP binding site [chemical binding]; other site
76869011998	Q-loop/lid; other site
76869011999	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
76869012000	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
76869012001	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
76869012002	ABC transporter signature motif; other site
76869012003	Walker B; other site
76869012004	D-loop; other site
76869012005	H-loop/switch region; other site
76869012006	Transcriptional regulators [Transcription]; Region: GntR; COG1802
76869012007	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869012008	DNA-binding site [nucleotide binding]; DNA binding site
76869012009	FCD domain; Region: FCD; cl11656
76869012010	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
76869012011	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869012012	catalytic loop [active]
76869012013	iron binding site [ion binding]; other site
76869012014	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
76869012015	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
76869012016	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
76869012017	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
76869012018	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
76869012019	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
76869012020	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
76869012021	XdhC Rossmann domain; Region: XdhC_C; pfam13478
76869012022	guanine deaminase; Provisional; Region: PRK09228
76869012023	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
76869012024	active site
76869012025	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
76869012026	amphipathic channel; other site
76869012027	Asn-Pro-Ala signature motifs; other site
76869012028	Transcriptional regulators [Transcription]; Region: GntR; COG1802
76869012029	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869012030	DNA-binding site [nucleotide binding]; DNA binding site
76869012031	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869012032	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
76869012033	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
76869012034	active site
76869012035	homotetramer interface [polypeptide binding]; other site
76869012036	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
76869012037	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
76869012038	active site
76869012039	catalytic site [active]
76869012040	tetramer interface [polypeptide binding]; other site
76869012041	OHCU decarboxylase; Region: UHCUDC; TIGR03164
76869012042	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
76869012043	ureidoglycolate hydrolase; Provisional; Region: PRK03606
76869012044	Predicted membrane protein [Function unknown]; Region: COG3748
76869012045	Protein of unknown function (DUF989); Region: DUF989; pfam06181
76869012046	Cytochrome c; Region: Cytochrom_C; pfam00034
76869012047	xanthine permease; Region: pbuX; TIGR03173
76869012048	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
76869012049	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
76869012050	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
76869012051	Sulfatase; Region: Sulfatase; pfam00884
76869012052	Protein of unknown function (DUF808); Region: DUF808; pfam05661
76869012053	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
76869012054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869012055	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
76869012056	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
76869012057	glyoxylate carboligase; Provisional; Region: PRK11269
76869012058	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869012059	PYR/PP interface [polypeptide binding]; other site
76869012060	dimer interface [polypeptide binding]; other site
76869012061	TPP binding site [chemical binding]; other site
76869012062	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869012063	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
76869012064	TPP-binding site [chemical binding]; other site
76869012065	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
76869012066	tartronate semialdehyde reductase; Provisional; Region: PRK15059
76869012067	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
76869012068	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
76869012069	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
76869012070	MOFRL family; Region: MOFRL; pfam05161
76869012071	pyruvate kinase; Provisional; Region: PRK06247
76869012072	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
76869012073	domain interfaces; other site
76869012074	active site
76869012075	Urea transporter; Region: UT; pfam03253
76869012076	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869012077	Ion transport protein; Region: Ion_trans; pfam00520
76869012078	Ion channel; Region: Ion_trans_2; pfam07885
76869012079	Double zinc ribbon; Region: DZR; pfam12773
76869012080	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
76869012081	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
76869012082	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
76869012083	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869012084	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
76869012085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869012086	S-adenosylmethionine binding site [chemical binding]; other site
76869012087	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
76869012088	EamA-like transporter family; Region: EamA; pfam00892
76869012089	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869012090	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
76869012091	AsnC family; Region: AsnC_trans_reg; pfam01037
76869012092	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
76869012093	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869012094	Na binding site [ion binding]; other site
76869012095	putative substrate binding site [chemical binding]; other site
76869012096	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
76869012097	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
76869012098	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869012099	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869012100	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
76869012101	catalytic core [active]
76869012102	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
76869012103	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
76869012104	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869012105	EamA-like transporter family; Region: EamA; pfam00892
76869012106	EamA-like transporter family; Region: EamA; pfam00892
76869012107	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
76869012108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012109	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869012110	dimerization interface [polypeptide binding]; other site
76869012111	Uncharacterized conserved protein [Function unknown]; Region: COG3791
76869012112	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
76869012113	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
76869012114	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
76869012115	NAD binding site [chemical binding]; other site
76869012116	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
76869012117	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
76869012118	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
76869012119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
76869012120	binding surface
76869012121	TPR motif; other site
76869012122	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
76869012123	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
76869012124	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869012125	catalytic residues [active]
76869012126	central insert; other site
76869012127	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
76869012128	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
76869012129	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
76869012130	heme exporter protein CcmC; Region: ccmC; TIGR01191
76869012131	heme exporter protein CcmB; Region: ccmB; TIGR01190
76869012132	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
76869012133	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
76869012134	Walker A/P-loop; other site
76869012135	ATP binding site [chemical binding]; other site
76869012136	Q-loop/lid; other site
76869012137	ABC transporter signature motif; other site
76869012138	Walker B; other site
76869012139	D-loop; other site
76869012140	H-loop/switch region; other site
76869012141	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
76869012142	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
76869012143	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
76869012144	Septum formation initiator; Region: DivIC; cl17659
76869012145	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
76869012146	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
76869012147	putative CheA interaction surface; other site
76869012148	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
76869012149	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
76869012150	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
76869012151	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869012152	Magnesium ion binding site [ion binding]; other site
76869012153	flagellar motor protein MotD; Reviewed; Region: PRK09038
76869012154	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
76869012155	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869012156	ligand binding site [chemical binding]; other site
76869012157	flagellar motor protein; Reviewed; Region: motC; PRK09109
76869012158	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
76869012159	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
76869012160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869012161	active site
76869012162	phosphorylation site [posttranslational modification]
76869012163	intermolecular recognition site; other site
76869012164	dimerization interface [polypeptide binding]; other site
76869012165	CheB methylesterase; Region: CheB_methylest; pfam01339
76869012166	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869012167	putative binding surface; other site
76869012168	active site
76869012169	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
76869012170	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
76869012171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869012172	ATP binding site [chemical binding]; other site
76869012173	Mg2+ binding site [ion binding]; other site
76869012174	G-X-G motif; other site
76869012175	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
76869012176	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
76869012177	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
76869012178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869012179	active site
76869012180	phosphorylation site [posttranslational modification]
76869012181	intermolecular recognition site; other site
76869012182	dimerization interface [polypeptide binding]; other site
76869012183	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
76869012184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869012185	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
76869012186	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869012187	DNA binding residues [nucleotide binding]
76869012188	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
76869012189	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
76869012190	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
76869012191	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
76869012192	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
76869012193	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
76869012194	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
76869012195	FHIPEP family; Region: FHIPEP; pfam00771
76869012196	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
76869012197	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
76869012198	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
76869012199	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
76869012200	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
76869012201	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
76869012202	flagellar motor switch protein; Validated; Region: fliN; PRK05698
76869012203	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
76869012204	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
76869012205	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
76869012206	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
76869012207	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
76869012208	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869012209	putative binding surface; other site
76869012210	active site
76869012211	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
76869012212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869012213	active site
76869012214	phosphorylation site [posttranslational modification]
76869012215	intermolecular recognition site; other site
76869012216	dimerization interface [polypeptide binding]; other site
76869012217	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
76869012218	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
76869012219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869012220	ATP binding site [chemical binding]; other site
76869012221	Mg2+ binding site [ion binding]; other site
76869012222	G-X-G motif; other site
76869012223	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
76869012224	anti sigma factor interaction site; other site
76869012225	regulatory phosphorylation site [posttranslational modification]; other site
76869012226	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
76869012227	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
76869012228	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
76869012229	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
76869012230	Walker A motif/ATP binding site; other site
76869012231	Walker B motif; other site
76869012232	flagellar assembly protein H; Validated; Region: fliH; PRK05687
76869012233	Flagellar assembly protein FliH; Region: FliH; pfam02108
76869012234	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
76869012235	MgtE intracellular N domain; Region: MgtE_N; cl15244
76869012236	FliG C-terminal domain; Region: FliG_C; pfam01706
76869012237	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
76869012238	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
76869012239	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
76869012240	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
76869012241	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869012242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869012243	active site
76869012244	phosphorylation site [posttranslational modification]
76869012245	intermolecular recognition site; other site
76869012246	dimerization interface [polypeptide binding]; other site
76869012247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869012248	Walker A motif; other site
76869012249	ATP binding site [chemical binding]; other site
76869012250	Walker B motif; other site
76869012251	arginine finger; other site
76869012252	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
76869012253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869012254	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869012255	putative active site [active]
76869012256	heme pocket [chemical binding]; other site
76869012257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869012258	dimer interface [polypeptide binding]; other site
76869012259	phosphorylation site [posttranslational modification]
76869012260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869012261	ATP binding site [chemical binding]; other site
76869012262	Mg2+ binding site [ion binding]; other site
76869012263	G-X-G motif; other site
76869012264	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869012265	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
76869012266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869012267	Walker A motif; other site
76869012268	ATP binding site [chemical binding]; other site
76869012269	Walker B motif; other site
76869012270	arginine finger; other site
76869012271	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869012272	flagellar protein FliS; Validated; Region: fliS; PRK05685
76869012273	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
76869012274	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
76869012275	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
76869012276	FlaG protein; Region: FlaG; pfam03646
76869012277	flagellin; Provisional; Region: PRK12806
76869012278	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
76869012279	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
76869012280	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
76869012281	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
76869012282	dimer interface [polypeptide binding]; other site
76869012283	active site
76869012284	CoA binding pocket [chemical binding]; other site
76869012285	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
76869012286	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
76869012287	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
76869012288	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
76869012289	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
76869012290	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
76869012291	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
76869012292	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
76869012293	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
76869012294	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
76869012295	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
76869012296	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
76869012297	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
76869012298	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
76869012299	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
76869012300	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
76869012301	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
76869012302	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
76869012303	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
76869012304	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
76869012305	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
76869012306	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
76869012307	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
76869012308	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
76869012309	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
76869012310	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
76869012311	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
76869012312	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
76869012313	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
76869012314	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
76869012315	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
76869012316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869012317	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
76869012318	Response regulator receiver domain; Region: Response_reg; pfam00072
76869012319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869012320	active site
76869012321	phosphorylation site [posttranslational modification]
76869012322	intermolecular recognition site; other site
76869012323	dimerization interface [polypeptide binding]; other site
76869012324	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
76869012325	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
76869012326	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
76869012327	FlgN protein; Region: FlgN; pfam05130
76869012328	Flagellar regulator YcgR; Region: YcgR; pfam07317
76869012329	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
76869012330	PilZ domain; Region: PilZ; pfam07238
76869012331	putative MFS family transporter protein; Provisional; Region: PRK03633
76869012332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869012333	putative substrate translocation pore; other site
76869012334	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869012335	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869012336	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869012337	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
76869012338	putative DNA binding site [nucleotide binding]; other site
76869012339	putative Zn2+ binding site [ion binding]; other site
76869012340	AsnC family; Region: AsnC_trans_reg; pfam01037
76869012341	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
76869012342	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
76869012343	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
76869012344	tetramer interface [polypeptide binding]; other site
76869012345	TPP-binding site [chemical binding]; other site
76869012346	heterodimer interface [polypeptide binding]; other site
76869012347	phosphorylation loop region [posttranslational modification]
76869012348	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
76869012349	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
76869012350	alpha subunit interface [polypeptide binding]; other site
76869012351	TPP binding site [chemical binding]; other site
76869012352	heterodimer interface [polypeptide binding]; other site
76869012353	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
76869012354	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
76869012355	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
76869012356	E3 interaction surface; other site
76869012357	lipoyl attachment site [posttranslational modification]; other site
76869012358	e3 binding domain; Region: E3_binding; pfam02817
76869012359	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
76869012360	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
76869012361	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869012362	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
76869012363	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869012364	PAS fold; Region: PAS_3; pfam08447
76869012365	putative active site [active]
76869012366	heme pocket [chemical binding]; other site
76869012367	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869012368	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869012369	metal binding site [ion binding]; metal-binding site
76869012370	active site
76869012371	I-site; other site
76869012372	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869012373	DNA-binding site [nucleotide binding]; DNA binding site
76869012374	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
76869012375	FCD domain; Region: FCD; pfam07729
76869012376	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869012377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869012378	putative substrate translocation pore; other site
76869012379	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
76869012380	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
76869012381	inhibitor site; inhibition site
76869012382	active site
76869012383	dimer interface [polypeptide binding]; other site
76869012384	catalytic residue [active]
76869012385	AzlC protein; Region: AzlC; pfam03591
76869012386	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
76869012387	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
76869012388	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
76869012389	AAA domain; Region: AAA_18; pfam13238
76869012390	active site
76869012391	Arc-like DNA binding domain; Region: Arc; pfam03869
76869012392	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
76869012393	MgtE intracellular N domain; Region: MgtE_N; smart00924
76869012394	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
76869012395	Divalent cation transporter; Region: MgtE; pfam01769
76869012396	carbon storage regulator; Provisional; Region: PRK01712
76869012397	aspartate kinase; Reviewed; Region: PRK06635
76869012398	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
76869012399	putative nucleotide binding site [chemical binding]; other site
76869012400	putative catalytic residues [active]
76869012401	putative Mg ion binding site [ion binding]; other site
76869012402	putative aspartate binding site [chemical binding]; other site
76869012403	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
76869012404	putative allosteric regulatory site; other site
76869012405	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
76869012406	putative allosteric regulatory residue; other site
76869012407	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
76869012408	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
76869012409	motif 1; other site
76869012410	active site
76869012411	motif 2; other site
76869012412	motif 3; other site
76869012413	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
76869012414	DHHA1 domain; Region: DHHA1; pfam02272
76869012415	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
76869012416	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
76869012417	putative active site [active]
76869012418	Zn binding site [ion binding]; other site
76869012419	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
76869012420	succinylarginine dihydrolase; Provisional; Region: PRK13281
76869012421	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
76869012422	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
76869012423	NAD(P) binding site [chemical binding]; other site
76869012424	catalytic residues [active]
76869012425	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
76869012426	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
76869012427	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
76869012428	arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245
76869012429	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
76869012430	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869012431	inhibitor-cofactor binding pocket; inhibition site
76869012432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869012433	catalytic residue [active]
76869012434	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869012435	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
76869012436	conserved cys residue [active]
76869012437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869012438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869012439	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
76869012440	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869012441	Walker A/P-loop; other site
76869012442	ATP binding site [chemical binding]; other site
76869012443	Q-loop/lid; other site
76869012444	ABC transporter signature motif; other site
76869012445	Walker B; other site
76869012446	D-loop; other site
76869012447	H-loop/switch region; other site
76869012448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869012449	dimer interface [polypeptide binding]; other site
76869012450	conserved gate region; other site
76869012451	putative PBP binding loops; other site
76869012452	ABC-ATPase subunit interface; other site
76869012453	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869012454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869012455	dimer interface [polypeptide binding]; other site
76869012456	conserved gate region; other site
76869012457	putative PBP binding loops; other site
76869012458	ABC-ATPase subunit interface; other site
76869012459	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
76869012460	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869012461	substrate binding pocket [chemical binding]; other site
76869012462	membrane-bound complex binding site; other site
76869012463	hinge residues; other site
76869012464	acetyl-CoA synthetase; Provisional; Region: PRK00174
76869012465	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
76869012466	active site
76869012467	CoA binding site [chemical binding]; other site
76869012468	acyl-activating enzyme (AAE) consensus motif; other site
76869012469	AMP binding site [chemical binding]; other site
76869012470	acetate binding site [chemical binding]; other site
76869012471	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869012472	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
76869012473	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
76869012474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869012475	putative active site [active]
76869012476	heme pocket [chemical binding]; other site
76869012477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869012478	Walker A motif; other site
76869012479	ATP binding site [chemical binding]; other site
76869012480	Walker B motif; other site
76869012481	arginine finger; other site
76869012482	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
76869012483	cofactor binding site; other site
76869012484	metal binding site [ion binding]; metal-binding site
76869012485	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
76869012486	aromatic arch; other site
76869012487	DCoH dimer interaction site [polypeptide binding]; other site
76869012488	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
76869012489	DCoH tetramer interaction site [polypeptide binding]; other site
76869012490	substrate binding site [chemical binding]; other site
76869012491	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
76869012492	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
76869012493	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
76869012494	major facilitator superfamily transporter; Provisional; Region: PRK05122
76869012495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869012496	putative substrate translocation pore; other site
76869012497	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
76869012498	FAD binding domain; Region: FAD_binding_4; pfam01565
76869012499	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
76869012500	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869012501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012502	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869012503	dimerization interface [polypeptide binding]; other site
76869012504	aromatic amino acid transporter; Provisional; Region: PRK10238
76869012505	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
76869012506	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
76869012507	RNA binding surface [nucleotide binding]; other site
76869012508	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
76869012509	probable active site [active]
76869012510	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
76869012511	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
76869012512	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
76869012513	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
76869012514	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
76869012515	active site
76869012516	Protein of unknown function (DUF1677); Region: DUF1677; pfam07911
76869012517	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
76869012518	intracellular septation protein A; Reviewed; Region: PRK00259
76869012519	YciI-like protein; Reviewed; Region: PRK11370
76869012520	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869012521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869012522	active site
76869012523	phosphorylation site [posttranslational modification]
76869012524	intermolecular recognition site; other site
76869012525	dimerization interface [polypeptide binding]; other site
76869012526	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869012527	DNA binding site [nucleotide binding]
76869012528	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
76869012529	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869012530	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869012531	dimerization interface [polypeptide binding]; other site
76869012532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
76869012533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869012534	ATP binding site [chemical binding]; other site
76869012535	Mg2+ binding site [ion binding]; other site
76869012536	G-X-G motif; other site
76869012537	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
76869012538	putative FMN binding site [chemical binding]; other site
76869012539	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
76869012540	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
76869012541	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869012542	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869012543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869012544	Protein of unknown function (DUF962); Region: DUF962; cl01879
76869012545	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
76869012546	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
76869012547	putative active site [active]
76869012548	putative metal binding site [ion binding]; other site
76869012549	Cupin domain; Region: Cupin_2; pfam07883
76869012550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869012551	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869012552	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869012553	EamA-like transporter family; Region: EamA; pfam00892
76869012554	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
76869012555	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
76869012556	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
76869012557	active site
76869012558	nucleophile elbow; other site
76869012559	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
76869012560	Surface antigen; Region: Bac_surface_Ag; pfam01103
76869012561	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
76869012562	MarR family; Region: MarR_2; pfam12802
76869012563	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
76869012564	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869012565	ATP binding site [chemical binding]; other site
76869012566	putative Mg++ binding site [ion binding]; other site
76869012567	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869012568	nucleotide binding region [chemical binding]; other site
76869012569	ATP-binding site [chemical binding]; other site
76869012570	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
76869012571	HRDC domain; Region: HRDC; pfam00570
76869012572	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
76869012573	yecA family protein; Region: ygfB_yecA; TIGR02292
76869012574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
76869012575	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
76869012576	Uncharacterized conserved protein [Function unknown]; Region: COG3148
76869012577	PAS domain; Region: PAS_9; pfam13426
76869012578	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869012579	putative active site [active]
76869012580	heme pocket [chemical binding]; other site
76869012581	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
76869012582	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869012583	dimer interface [polypeptide binding]; other site
76869012584	putative CheW interface [polypeptide binding]; other site
76869012585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869012586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869012588	dimerization interface [polypeptide binding]; other site
76869012589	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
76869012590	agmatinase; Region: agmatinase; TIGR01230
76869012591	oligomer interface [polypeptide binding]; other site
76869012592	putative active site [active]
76869012593	Mn binding site [ion binding]; other site
76869012594	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
76869012595	Na binding site [ion binding]; other site
76869012596	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869012597	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012598	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
76869012599	putative dimerization interface [polypeptide binding]; other site
76869012600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869012601	putative substrate translocation pore; other site
76869012602	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869012603	EamA-like transporter family; Region: EamA; pfam00892
76869012604	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
76869012605	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
76869012606	helicase 45; Provisional; Region: PTZ00424
76869012607	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
76869012608	ATP binding site [chemical binding]; other site
76869012609	Mg++ binding site [ion binding]; other site
76869012610	motif III; other site
76869012611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869012612	nucleotide binding region [chemical binding]; other site
76869012613	ATP-binding site [chemical binding]; other site
76869012614	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
76869012615	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869012616	hypothetical protein; Provisional; Region: PRK09256
76869012617	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
76869012618	Predicted permeases [General function prediction only]; Region: COG0679
76869012619	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
76869012620	azoreductase; Reviewed; Region: PRK00170
76869012621	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
76869012622	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
76869012623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869012624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012625	LysR substrate binding domain; Region: LysR_substrate; pfam03466
76869012626	dimerization interface [polypeptide binding]; other site
76869012627	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
76869012628	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869012629	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
76869012630	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
76869012631	substrate binding site [chemical binding]; other site
76869012632	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
76869012633	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869012634	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869012635	Walker A/P-loop; other site
76869012636	ATP binding site [chemical binding]; other site
76869012637	Q-loop/lid; other site
76869012638	ABC transporter signature motif; other site
76869012639	Walker B; other site
76869012640	D-loop; other site
76869012641	H-loop/switch region; other site
76869012642	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
76869012643	Protein of unknown function, DUF482; Region: DUF482; pfam04339
76869012644	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
76869012645	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
76869012646	dimer interface [polypeptide binding]; other site
76869012647	active site
76869012648	CoA binding pocket [chemical binding]; other site
76869012649	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
76869012650	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869012651	ATP binding site [chemical binding]; other site
76869012652	putative Mg++ binding site [ion binding]; other site
76869012653	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869012654	nucleotide binding region [chemical binding]; other site
76869012655	ATP-binding site [chemical binding]; other site
76869012656	Helicase associated domain (HA2); Region: HA2; pfam04408
76869012657	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
76869012658	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
76869012659	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869012660	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869012661	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869012662	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869012663	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
76869012664	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
76869012665	acyl-activating enzyme (AAE) consensus motif; other site
76869012666	putative AMP binding site [chemical binding]; other site
76869012667	putative active site [active]
76869012668	putative CoA binding site [chemical binding]; other site
76869012669	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
76869012670	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
76869012671	acyl-activating enzyme (AAE) consensus motif; other site
76869012672	putative AMP binding site [chemical binding]; other site
76869012673	putative active site [active]
76869012674	putative CoA binding site [chemical binding]; other site
76869012675	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
76869012676	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869012677	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869012678	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
76869012679	dimer interaction site [polypeptide binding]; other site
76869012680	substrate-binding tunnel; other site
76869012681	active site
76869012682	catalytic site [active]
76869012683	substrate binding site [chemical binding]; other site
76869012684	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
76869012685	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869012686	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
76869012687	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
76869012688	putative hydrophobic ligand binding site [chemical binding]; other site
76869012689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
76869012690	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
76869012691	SnoaL-like domain; Region: SnoaL_3; pfam13474
76869012692	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
76869012693	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869012694	Coenzyme A binding pocket [chemical binding]; other site
76869012695	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
76869012696	active site
76869012697	catalytic residues [active]
76869012698	metal binding site [ion binding]; metal-binding site
76869012699	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
76869012700	CsbD-like; Region: CsbD; pfam05532
76869012701	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
76869012702	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
76869012703	S1 domain; Region: S1_2; pfam13509
76869012704	S1 domain; Region: S1_2; pfam13509
76869012705	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869012706	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869012707	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869012708	N-terminal plug; other site
76869012709	ligand-binding site [chemical binding]; other site
76869012710	fec operon regulator FecR; Reviewed; Region: PRK09774
76869012711	FecR protein; Region: FecR; pfam04773
76869012712	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
76869012713	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869012714	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869012715	DNA binding residues [nucleotide binding]
76869012716	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
76869012717	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
76869012718	EamA-like transporter family; Region: EamA; pfam00892
76869012719	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
76869012720	EamA-like transporter family; Region: EamA; pfam00892
76869012721	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
76869012722	Uncharacterized conserved protein [Function unknown]; Region: COG1262
76869012723	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
76869012724	Secretin and TonB N terminus short domain; Region: STN; pfam07660
76869012725	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
76869012726	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869012727	N-terminal plug; other site
76869012728	ligand-binding site [chemical binding]; other site
76869012729	Condensation domain; Region: Condensation; pfam00668
76869012730	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012731	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869012732	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012733	acyl-activating enzyme (AAE) consensus motif; other site
76869012734	AMP binding site [chemical binding]; other site
76869012735	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012736	Condensation domain; Region: Condensation; pfam00668
76869012737	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012738	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
76869012739	Condensation domain; Region: Condensation; pfam00668
76869012740	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012741	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012742	acyl-activating enzyme (AAE) consensus motif; other site
76869012743	AMP binding site [chemical binding]; other site
76869012744	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012745	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
76869012746	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012747	acyl-activating enzyme (AAE) consensus motif; other site
76869012748	AMP binding site [chemical binding]; other site
76869012749	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012750	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
76869012751	Condensation domain; Region: Condensation; pfam00668
76869012752	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012753	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869012754	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
76869012755	acyl-activating enzyme (AAE) consensus motif; other site
76869012756	AMP binding site [chemical binding]; other site
76869012757	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012758	Condensation domain; Region: Condensation; pfam00668
76869012759	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012760	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869012761	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012762	acyl-activating enzyme (AAE) consensus motif; other site
76869012763	AMP binding site [chemical binding]; other site
76869012764	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012765	Condensation domain; Region: Condensation; pfam00668
76869012766	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012767	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
76869012768	Condensation domain; Region: Condensation; pfam00668
76869012769	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012770	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012771	acyl-activating enzyme (AAE) consensus motif; other site
76869012772	AMP binding site [chemical binding]; other site
76869012773	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012774	Condensation domain; Region: Condensation; pfam00668
76869012775	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012776	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869012777	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012778	acyl-activating enzyme (AAE) consensus motif; other site
76869012779	AMP binding site [chemical binding]; other site
76869012780	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012781	Condensation domain; Region: Condensation; pfam00668
76869012782	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
76869012783	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
76869012784	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
76869012785	acyl-activating enzyme (AAE) consensus motif; other site
76869012786	AMP binding site [chemical binding]; other site
76869012787	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
76869012788	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
76869012789	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
76869012790	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
76869012791	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869012792	hypothetical protein; Region: PHA02096
76869012793	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
76869012794	Walker A/P-loop; other site
76869012795	ATP binding site [chemical binding]; other site
76869012796	Q-loop/lid; other site
76869012797	ABC transporter signature motif; other site
76869012798	Walker B; other site
76869012799	D-loop; other site
76869012800	H-loop/switch region; other site
76869012801	Archaeal ATPase; Region: Arch_ATPase; pfam01637
76869012802	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
76869012803	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
76869012804	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
76869012805	dimer interface [polypeptide binding]; other site
76869012806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869012807	catalytic residue [active]
76869012808	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
76869012809	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869012810	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869012811	Walker A motif; other site
76869012812	ATP binding site [chemical binding]; other site
76869012813	Walker B motif; other site
76869012814	arginine finger; other site
76869012815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
76869012816	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
76869012817	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
76869012818	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
76869012819	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
76869012820	putative active site [active]
76869012821	benzoate transport; Region: 2A0115; TIGR00895
76869012822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869012823	putative substrate translocation pore; other site
76869012824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869012825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012826	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869012827	dimerization interface [polypeptide binding]; other site
76869012828	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
76869012829	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
76869012830	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
76869012831	putative active site [active]
76869012832	putative dimer interface [polypeptide binding]; other site
76869012833	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
76869012834	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869012835	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
76869012836	active site
76869012837	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
76869012838	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
76869012839	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
76869012840	NAD(P) binding site [chemical binding]; other site
76869012841	catalytic residues [active]
76869012842	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
76869012843	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
76869012844	inhibitor site; inhibition site
76869012845	active site
76869012846	dimer interface [polypeptide binding]; other site
76869012847	catalytic residue [active]
76869012848	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
76869012849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869012850	putative substrate translocation pore; other site
76869012851	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869012852	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869012853	Transcriptional regulators [Transcription]; Region: GntR; COG1802
76869012854	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869012855	DNA-binding site [nucleotide binding]; DNA binding site
76869012856	FCD domain; Region: FCD; pfam07729
76869012857	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
76869012858	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
76869012859	hypothetical protein; Provisional; Region: PRK05170
76869012860	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
76869012861	putative FMN binding site [chemical binding]; other site
76869012862	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
76869012863	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
76869012864	NAD binding site [chemical binding]; other site
76869012865	ligand binding site [chemical binding]; other site
76869012866	catalytic site [active]
76869012867	YcgL domain; Region: YcgL; pfam05166
76869012868	ribonuclease D; Region: rnd; TIGR01388
76869012869	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
76869012870	catalytic site [active]
76869012871	putative active site [active]
76869012872	putative substrate binding site [chemical binding]; other site
76869012873	HRDC domain; Region: HRDC; pfam00570
76869012874	putative metal dependent hydrolase; Provisional; Region: PRK11598
76869012875	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
76869012876	Sulfatase; Region: Sulfatase; pfam00884
76869012877	Protein of unknown function (DUF465); Region: DUF465; pfam04325
76869012878	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
76869012879	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
76869012880	homodimer interface [polypeptide binding]; other site
76869012881	substrate-cofactor binding pocket; other site
76869012882	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869012883	catalytic residue [active]
76869012884	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869012885	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869012886	putative DNA binding site [nucleotide binding]; other site
76869012887	putative Zn2+ binding site [ion binding]; other site
76869012888	AsnC family; Region: AsnC_trans_reg; pfam01037
76869012889	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
76869012890	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
76869012891	putative molybdopterin cofactor binding site [chemical binding]; other site
76869012892	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
76869012893	putative molybdopterin cofactor binding site; other site
76869012894	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
76869012895	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869012896	FeS/SAM binding site; other site
76869012897	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
76869012898	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
76869012899	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
76869012900	MPT binding site; other site
76869012901	trimer interface [polypeptide binding]; other site
76869012902	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869012903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869012904	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869012905	dimerization interface [polypeptide binding]; other site
76869012906	PAS fold; Region: PAS_4; pfam08448
76869012907	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869012908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869012909	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869012910	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
76869012911	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
76869012912	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
76869012913	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
76869012914	inhibitor site; inhibition site
76869012915	active site
76869012916	dimer interface [polypeptide binding]; other site
76869012917	catalytic residue [active]
76869012918	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
76869012919	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
76869012920	dimer interface [polypeptide binding]; other site
76869012921	NADP binding site [chemical binding]; other site
76869012922	catalytic residues [active]
76869012923	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
76869012924	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869012925	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869012926	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
76869012927	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
76869012928	active site
76869012929	FMN binding site [chemical binding]; other site
76869012930	substrate binding site [chemical binding]; other site
76869012931	homotetramer interface [polypeptide binding]; other site
76869012932	catalytic residue [active]
76869012933	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869012934	dimerization interface [polypeptide binding]; other site
76869012935	putative DNA binding site [nucleotide binding]; other site
76869012936	putative Zn2+ binding site [ion binding]; other site
76869012937	Predicted transcriptional regulator [Transcription]; Region: COG2345
76869012938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869012939	putative DNA binding site [nucleotide binding]; other site
76869012940	putative Zn2+ binding site [ion binding]; other site
76869012941	malate:quinone oxidoreductase; Validated; Region: PRK05257
76869012942	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
76869012943	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
76869012944	LysE type translocator; Region: LysE; cl00565
76869012945	Bacterial SH3 domain; Region: SH3_3; pfam08239
76869012946	integrase; Provisional; Region: PRK09692
76869012947	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869012948	active site
76869012949	DNA binding site [nucleotide binding]
76869012950	Int/Topo IB signature motif; other site
76869012951	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
76869012952	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
76869012953	Sel1-like repeats; Region: SEL1; smart00671
76869012954	Sel1-like repeats; Region: SEL1; smart00671
76869012955	Sel1-like repeats; Region: SEL1; smart00671
76869012956	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
76869012957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869012958	Walker A/P-loop; other site
76869012959	ATP binding site [chemical binding]; other site
76869012960	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
76869012961	putative active site [active]
76869012962	putative metal-binding site [ion binding]; other site
76869012963	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
76869012964	Part of AAA domain; Region: AAA_19; pfam13245
76869012965	Family description; Region: UvrD_C_2; pfam13538
76869012966	Predicted periplasmic protein [Function unknown]; Region: COG3904
76869012967	PLD-like domain; Region: PLDc_2; pfam13091
76869012968	Fumarase C-terminus; Region: Fumerase_C; cl00795
76869012969	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
76869012970	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
76869012971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869012972	Walker A motif; other site
76869012973	ATP binding site [chemical binding]; other site
76869012974	Walker B motif; other site
76869012975	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869012976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869012977	non-specific DNA binding site [nucleotide binding]; other site
76869012978	salt bridge; other site
76869012979	sequence-specific DNA binding site [nucleotide binding]; other site
76869012980	ParA-like protein; Provisional; Region: PHA02518
76869012981	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869012982	P-loop; other site
76869012983	Magnesium ion binding site [ion binding]; other site
76869012984	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869012985	non-specific DNA binding site [nucleotide binding]; other site
76869012986	salt bridge; other site
76869012987	sequence-specific DNA binding site [nucleotide binding]; other site
76869012988	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
76869012989	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
76869012990	ATP binding site [chemical binding]; other site
76869012991	active site
76869012992	substrate binding site [chemical binding]; other site
76869012993	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
76869012994	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
76869012995	dihydrodipicolinate synthase; Region: dapA; TIGR00674
76869012996	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
76869012997	dimer interface [polypeptide binding]; other site
76869012998	active site
76869012999	catalytic residue [active]
76869013000	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
76869013001	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
76869013002	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
76869013003	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
76869013004	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
76869013005	catalytic triad [active]
76869013006	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
76869013007	Domain of unknown function DUF20; Region: UPF0118; pfam01594
76869013008	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
76869013009	CPxP  motif; other site
76869013010	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
76869013011	Peptidase family M48; Region: Peptidase_M48; cl12018
76869013012	quinolinate synthetase; Provisional; Region: PRK09375
76869013013	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
76869013014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
76869013015	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869013016	Cache domain; Region: Cache_1; pfam02743
76869013017	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869013018	dimerization interface [polypeptide binding]; other site
76869013019	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869013020	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869013021	dimer interface [polypeptide binding]; other site
76869013022	putative CheW interface [polypeptide binding]; other site
76869013023	Cation efflux family; Region: Cation_efflux; cl00316
76869013024	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
76869013025	Ligand Binding Site [chemical binding]; other site
76869013026	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
76869013027	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
76869013028	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
76869013029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
76869013030	binding surface
76869013031	TPR motif; other site
76869013032	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869013033	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869013034	ligand binding site [chemical binding]; other site
76869013035	translocation protein TolB; Provisional; Region: tolB; PRK00178
76869013036	TolB amino-terminal domain; Region: TolB_N; pfam04052
76869013037	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
76869013038	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
76869013039	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
76869013040	TolA protein; Region: tolA_full; TIGR02794
76869013041	TolA protein; Region: tolA_full; TIGR02794
76869013042	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
76869013043	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
76869013044	TolR protein; Region: tolR; TIGR02801
76869013045	TolQ protein; Region: tolQ; TIGR02796
76869013046	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
76869013047	active site
76869013048	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
76869013049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869013050	Walker A motif; other site
76869013051	ATP binding site [chemical binding]; other site
76869013052	Walker B motif; other site
76869013053	arginine finger; other site
76869013054	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
76869013055	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
76869013056	RuvA N terminal domain; Region: RuvA_N; pfam01330
76869013057	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
76869013058	active site
76869013059	putative DNA-binding cleft [nucleotide binding]; other site
76869013060	dimer interface [polypeptide binding]; other site
76869013061	hypothetical protein; Validated; Region: PRK00110
76869013062	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
76869013063	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
76869013064	dimer interface [polypeptide binding]; other site
76869013065	anticodon binding site; other site
76869013066	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
76869013067	homodimer interface [polypeptide binding]; other site
76869013068	motif 1; other site
76869013069	active site
76869013070	motif 2; other site
76869013071	GAD domain; Region: GAD; pfam02938
76869013072	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
76869013073	active site
76869013074	motif 3; other site
76869013075	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
76869013076	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
76869013077	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
76869013078	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
76869013079	dimerization interface [polypeptide binding]; other site
76869013080	DPS ferroxidase diiron center [ion binding]; other site
76869013081	ion pore; other site
76869013082	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
76869013083	DNA-binding site [nucleotide binding]; DNA binding site
76869013084	RNA-binding motif; other site
76869013085	hypothetical protein; Provisional; Region: PRK00295
76869013086	HIT domain; Region: HIT; pfam01230
76869013087	nucleotide binding site/active site [active]
76869013088	HIT family signature motif; other site
76869013089	catalytic residue [active]
76869013090	outer membrane porin, OprD family; Region: OprD; pfam03573
76869013091	prolyl-tRNA synthetase; Provisional; Region: PRK09194
76869013092	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
76869013093	dimer interface [polypeptide binding]; other site
76869013094	motif 1; other site
76869013095	active site
76869013096	motif 2; other site
76869013097	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
76869013098	putative deacylase active site [active]
76869013099	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
76869013100	active site
76869013101	motif 3; other site
76869013102	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
76869013103	anticodon binding site; other site
76869013104	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
76869013105	active site
76869013106	DNA polymerase IV; Validated; Region: PRK02406
76869013107	DNA binding site [nucleotide binding]
76869013108	Predicted integral membrane protein [Function unknown]; Region: COG0392
76869013109	Uncharacterized conserved protein [Function unknown]; Region: COG2898
76869013110	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
76869013111	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
76869013112	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
76869013113	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
76869013114	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
76869013115	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
76869013116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869013117	FeS/SAM binding site; other site
76869013118	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
76869013119	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869013120	Coenzyme A binding pocket [chemical binding]; other site
76869013121	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
76869013122	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
76869013123	RNA binding surface [nucleotide binding]; other site
76869013124	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
76869013125	active site
76869013126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
76869013127	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
76869013128	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
76869013129	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
76869013130	homodimer interaction site [polypeptide binding]; other site
76869013131	cofactor binding site; other site
76869013132	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
76869013133	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
76869013134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013135	dimer interface [polypeptide binding]; other site
76869013136	phosphorylation site [posttranslational modification]
76869013137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013138	ATP binding site [chemical binding]; other site
76869013139	Mg2+ binding site [ion binding]; other site
76869013140	G-X-G motif; other site
76869013141	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
76869013142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013143	active site
76869013144	phosphorylation site [posttranslational modification]
76869013145	intermolecular recognition site; other site
76869013146	dimerization interface [polypeptide binding]; other site
76869013147	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869013148	DNA binding site [nucleotide binding]
76869013149	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
76869013150	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
76869013151	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
76869013152	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
76869013153	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
76869013154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869013155	dimerization interface [polypeptide binding]; other site
76869013156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013157	dimer interface [polypeptide binding]; other site
76869013158	phosphorylation site [posttranslational modification]
76869013159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013160	ATP binding site [chemical binding]; other site
76869013161	Mg2+ binding site [ion binding]; other site
76869013162	G-X-G motif; other site
76869013163	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869013164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013165	active site
76869013166	phosphorylation site [posttranslational modification]
76869013167	intermolecular recognition site; other site
76869013168	dimerization interface [polypeptide binding]; other site
76869013169	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869013170	DNA binding site [nucleotide binding]
76869013171	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
76869013172	ATP cone domain; Region: ATP-cone; pfam03477
76869013173	ATP cone domain; Region: ATP-cone; pfam03477
76869013174	Class I ribonucleotide reductase; Region: RNR_I; cd01679
76869013175	active site
76869013176	dimer interface [polypeptide binding]; other site
76869013177	catalytic residues [active]
76869013178	effector binding site; other site
76869013179	R2 peptide binding site; other site
76869013180	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
76869013181	dimer interface [polypeptide binding]; other site
76869013182	putative radical transfer pathway; other site
76869013183	diiron center [ion binding]; other site
76869013184	tyrosyl radical; other site
76869013185	outer membrane porin, OprD family; Region: OprD; pfam03573
76869013186	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
76869013187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869013188	NAD(P) binding site [chemical binding]; other site
76869013189	active site
76869013190	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
76869013191	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
76869013192	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
76869013193	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
76869013194	DctM-like transporters; Region: DctM; pfam06808
76869013195	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
76869013196	EamA-like transporter family; Region: EamA; pfam00892
76869013197	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
76869013198	active site
76869013199	catalytic residues [active]
76869013200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013201	D-galactonate transporter; Region: 2A0114; TIGR00893
76869013202	putative substrate translocation pore; other site
76869013203	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869013204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013205	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
76869013206	putative effector binding pocket; other site
76869013207	putative dimerization interface [polypeptide binding]; other site
76869013208	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
76869013209	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
76869013210	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
76869013211	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
76869013212	FAD binding pocket [chemical binding]; other site
76869013213	FAD binding motif [chemical binding]; other site
76869013214	phosphate binding motif [ion binding]; other site
76869013215	beta-alpha-beta structure motif; other site
76869013216	NAD binding pocket [chemical binding]; other site
76869013217	Heme binding  pocket [chemical binding]; other site
76869013218	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
76869013219	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869013220	catalytic loop [active]
76869013221	iron binding site [ion binding]; other site
76869013222	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869013223	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
76869013224	putative C-terminal domain interface [polypeptide binding]; other site
76869013225	putative GSH binding site (G-site) [chemical binding]; other site
76869013226	putative dimer interface [polypeptide binding]; other site
76869013227	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
76869013228	putative N-terminal domain interface [polypeptide binding]; other site
76869013229	putative dimer interface [polypeptide binding]; other site
76869013230	putative substrate binding pocket (H-site) [chemical binding]; other site
76869013231	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
76869013232	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
76869013233	active site
76869013234	homotetramer interface [polypeptide binding]; other site
76869013235	homodimer interface [polypeptide binding]; other site
76869013236	Predicted amidohydrolase [General function prediction only]; Region: COG0388
76869013237	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
76869013238	putative active site [active]
76869013239	catalytic triad [active]
76869013240	putative dimer interface [polypeptide binding]; other site
76869013241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869013242	acetolactate synthase; Reviewed; Region: PRK08322
76869013243	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869013244	PYR/PP interface [polypeptide binding]; other site
76869013245	dimer interface [polypeptide binding]; other site
76869013246	TPP binding site [chemical binding]; other site
76869013247	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869013248	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
76869013249	TPP-binding site [chemical binding]; other site
76869013250	dimer interface [polypeptide binding]; other site
76869013251	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
76869013252	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
76869013253	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
76869013254	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
76869013255	MASE2 domain; Region: MASE2; pfam05230
76869013256	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869013257	metal binding site [ion binding]; metal-binding site
76869013258	active site
76869013259	I-site; other site
76869013260	CHASE4 domain; Region: CHASE4; pfam05228
76869013261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869013262	PAS domain; Region: PAS_9; pfam13426
76869013263	putative active site [active]
76869013264	heme pocket [chemical binding]; other site
76869013265	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869013266	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869013267	metal binding site [ion binding]; metal-binding site
76869013268	active site
76869013269	I-site; other site
76869013270	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869013271	Protein of unknown function (DUF2025); Region: DUF2025; pfam09634
76869013272	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869013273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013274	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
76869013275	putative effector binding pocket; other site
76869013276	putative dimerization interface [polypeptide binding]; other site
76869013277	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
76869013278	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869013279	NAD(P) binding site [chemical binding]; other site
76869013280	active site
76869013281	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
76869013282	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869013283	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869013284	Fusaric acid resistance protein family; Region: FUSC; pfam04632
76869013285	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
76869013286	ATP-dependent helicase HepA; Validated; Region: PRK04914
76869013287	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869013288	ATP binding site [chemical binding]; other site
76869013289	putative Mg++ binding site [ion binding]; other site
76869013290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869013291	nucleotide binding region [chemical binding]; other site
76869013292	ATP-binding site [chemical binding]; other site
76869013293	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
76869013294	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
76869013295	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869013296	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869013297	metal binding site [ion binding]; metal-binding site
76869013298	active site
76869013299	I-site; other site
76869013300	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869013301	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
76869013302	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
76869013303	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
76869013304	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
76869013305	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
76869013306	dimerization interface [polypeptide binding]; other site
76869013307	ligand binding site [chemical binding]; other site
76869013308	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
76869013309	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
76869013310	TM-ABC transporter signature motif; other site
76869013311	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
76869013312	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
76869013313	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
76869013314	TM-ABC transporter signature motif; other site
76869013315	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
76869013316	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
76869013317	Walker A/P-loop; other site
76869013318	ATP binding site [chemical binding]; other site
76869013319	Q-loop/lid; other site
76869013320	ABC transporter signature motif; other site
76869013321	Walker B; other site
76869013322	D-loop; other site
76869013323	H-loop/switch region; other site
76869013324	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
76869013325	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
76869013326	Walker A/P-loop; other site
76869013327	ATP binding site [chemical binding]; other site
76869013328	Q-loop/lid; other site
76869013329	ABC transporter signature motif; other site
76869013330	Walker B; other site
76869013331	D-loop; other site
76869013332	H-loop/switch region; other site
76869013333	Predicted membrane protein [Function unknown]; Region: COG3650
76869013334	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
76869013335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869013336	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
76869013337	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
76869013338	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
76869013339	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
76869013340	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
76869013341	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869013342	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869013343	ligand binding site [chemical binding]; other site
76869013344	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
76869013345	Beta-lactamase; Region: Beta-lactamase; pfam00144
76869013346	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
76869013347	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
76869013348	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
76869013349	Predicted integral membrane protein [Function unknown]; Region: COG5615
76869013350	Predicted membrane protein [Function unknown]; Region: COG3776
76869013351	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869013352	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869013353	ligand binding site [chemical binding]; other site
76869013354	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869013355	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869013356	ligand binding site [chemical binding]; other site
76869013357	hypothetical protein; Provisional; Region: PRK00183
76869013358	SEC-C motif; Region: SEC-C; pfam02810
76869013359	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
76869013360	SEC-C motif; Region: SEC-C; pfam02810
76869013361	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
76869013362	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
76869013363	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
76869013364	catalytic residue [active]
76869013365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013366	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869013367	putative substrate translocation pore; other site
76869013368	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
76869013369	serine O-acetyltransferase; Region: cysE; TIGR01172
76869013370	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
76869013371	trimer interface [polypeptide binding]; other site
76869013372	active site
76869013373	substrate binding site [chemical binding]; other site
76869013374	CoA binding site [chemical binding]; other site
76869013375	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869013376	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869013377	DNA-binding site [nucleotide binding]; DNA binding site
76869013378	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869013379	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869013380	homodimer interface [polypeptide binding]; other site
76869013381	catalytic residue [active]
76869013382	Penicillin amidase; Region: Penicil_amidase; pfam01804
76869013383	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
76869013384	active site
76869013385	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
76869013386	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
76869013387	ATP-dependent DNA ligase; Validated; Region: PRK09247
76869013388	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
76869013389	active site
76869013390	DNA binding site [nucleotide binding]
76869013391	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
76869013392	DNA binding site [nucleotide binding]
76869013393	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
76869013394	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
76869013395	active site
76869013396	Zn binding site [ion binding]; other site
76869013397	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
76869013398	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869013399	ATP binding site [chemical binding]; other site
76869013400	putative Mg++ binding site [ion binding]; other site
76869013401	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869013402	nucleotide binding region [chemical binding]; other site
76869013403	ATP-binding site [chemical binding]; other site
76869013404	DEAD/H associated; Region: DEAD_assoc; pfam08494
76869013405	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
76869013406	putative active site [active]
76869013407	putative metal binding site [ion binding]; other site
76869013408	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
76869013409	trimer interface [polypeptide binding]; other site
76869013410	active site
76869013411	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
76869013412	DNA-binding site [nucleotide binding]; DNA binding site
76869013413	RNA-binding motif; other site
76869013414	antiporter inner membrane protein; Provisional; Region: PRK11670
76869013415	Domain of unknown function DUF59; Region: DUF59; pfam01883
76869013416	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
76869013417	Walker A motif; other site
76869013418	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
76869013419	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
76869013420	active site
76869013421	HIGH motif; other site
76869013422	KMSKS motif; other site
76869013423	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
76869013424	tRNA binding surface [nucleotide binding]; other site
76869013425	anticodon binding site; other site
76869013426	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
76869013427	dimer interface [polypeptide binding]; other site
76869013428	putative tRNA-binding site [nucleotide binding]; other site
76869013429	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
76869013430	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
76869013431	electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947
76869013432	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
76869013433	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
76869013434	minor groove reading motif; other site
76869013435	helix-hairpin-helix signature motif; other site
76869013436	substrate binding pocket [chemical binding]; other site
76869013437	active site
76869013438	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
76869013439	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
76869013440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013441	active site
76869013442	phosphorylation site [posttranslational modification]
76869013443	intermolecular recognition site; other site
76869013444	dimerization interface [polypeptide binding]; other site
76869013445	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869013446	DNA binding residues [nucleotide binding]
76869013447	dimerization interface [polypeptide binding]; other site
76869013448	argininosuccinate synthase; Provisional; Region: PRK13820
76869013449	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
76869013450	ANP binding site [chemical binding]; other site
76869013451	Substrate Binding Site II [chemical binding]; other site
76869013452	Substrate Binding Site I [chemical binding]; other site
76869013453	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869013454	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869013455	ligand binding site [chemical binding]; other site
76869013456	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
76869013457	active site
76869013458	substrate binding pocket [chemical binding]; other site
76869013459	dimer interface [polypeptide binding]; other site
76869013460	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
76869013461	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
76869013462	dimer interface [polypeptide binding]; other site
76869013463	catalytic site [active]
76869013464	putative active site [active]
76869013465	putative substrate binding site [chemical binding]; other site
76869013466	peroxidase; Provisional; Region: PRK15000
76869013467	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
76869013468	dimer interface [polypeptide binding]; other site
76869013469	decamer (pentamer of dimers) interface [polypeptide binding]; other site
76869013470	catalytic triad [active]
76869013471	peroxidatic and resolving cysteines [active]
76869013472	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
76869013473	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
76869013474	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
76869013475	heme binding site [chemical binding]; other site
76869013476	ferroxidase pore; other site
76869013477	ferroxidase diiron center [ion binding]; other site
76869013478	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
76869013479	putative GSH binding site [chemical binding]; other site
76869013480	catalytic residues [active]
76869013481	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
76869013482	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
76869013483	putative [Fe4-S4] binding site [ion binding]; other site
76869013484	putative molybdopterin cofactor binding site [chemical binding]; other site
76869013485	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
76869013486	putative molybdopterin cofactor binding site; other site
76869013487	ornithine carbamoyltransferase; Provisional; Region: PRK00779
76869013488	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
76869013489	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
76869013490	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
76869013491	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
76869013492	Walker A/P-loop; other site
76869013493	ATP binding site [chemical binding]; other site
76869013494	Q-loop/lid; other site
76869013495	ABC transporter signature motif; other site
76869013496	Walker B; other site
76869013497	D-loop; other site
76869013498	H-loop/switch region; other site
76869013499	TOBE domain; Region: TOBE_2; pfam08402
76869013500	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
76869013501	putative deacylase active site [active]
76869013502	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
76869013503	amphipathic channel; other site
76869013504	Asn-Pro-Ala signature motifs; other site
76869013505	glycerol kinase; Provisional; Region: glpK; PRK00047
76869013506	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
76869013507	N- and C-terminal domain interface [polypeptide binding]; other site
76869013508	active site
76869013509	MgATP binding site [chemical binding]; other site
76869013510	catalytic site [active]
76869013511	metal binding site [ion binding]; metal-binding site
76869013512	glycerol binding site [chemical binding]; other site
76869013513	homotetramer interface [polypeptide binding]; other site
76869013514	homodimer interface [polypeptide binding]; other site
76869013515	protein IIAGlc interface [polypeptide binding]; other site
76869013516	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
76869013517	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
76869013518	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
76869013519	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
76869013520	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
76869013521	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
76869013522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869013523	substrate binding pocket [chemical binding]; other site
76869013524	membrane-bound complex binding site; other site
76869013525	hinge residues; other site
76869013526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869013527	dimer interface [polypeptide binding]; other site
76869013528	conserved gate region; other site
76869013529	putative PBP binding loops; other site
76869013530	ABC-ATPase subunit interface; other site
76869013531	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869013532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869013533	dimer interface [polypeptide binding]; other site
76869013534	conserved gate region; other site
76869013535	putative PBP binding loops; other site
76869013536	ABC-ATPase subunit interface; other site
76869013537	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869013538	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869013539	Walker A/P-loop; other site
76869013540	ATP binding site [chemical binding]; other site
76869013541	Q-loop/lid; other site
76869013542	ABC transporter signature motif; other site
76869013543	Walker B; other site
76869013544	D-loop; other site
76869013545	H-loop/switch region; other site
76869013546	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
76869013547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013548	dimer interface [polypeptide binding]; other site
76869013549	phosphorylation site [posttranslational modification]
76869013550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013551	Mg2+ binding site [ion binding]; other site
76869013552	G-X-G motif; other site
76869013553	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869013554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013555	active site
76869013556	phosphorylation site [posttranslational modification]
76869013557	intermolecular recognition site; other site
76869013558	dimerization interface [polypeptide binding]; other site
76869013559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869013560	Walker A motif; other site
76869013561	ATP binding site [chemical binding]; other site
76869013562	Walker B motif; other site
76869013563	arginine finger; other site
76869013564	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869013565	GlpM protein; Region: GlpM; pfam06942
76869013566	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
76869013567	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
76869013568	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
76869013569	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013570	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
76869013571	putative dimerization interface [polypeptide binding]; other site
76869013572	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
76869013573	nudix motif; other site
76869013574	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
76869013575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869013576	ATP binding site [chemical binding]; other site
76869013577	putative Mg++ binding site [ion binding]; other site
76869013578	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869013579	nucleotide binding region [chemical binding]; other site
76869013580	ATP-binding site [chemical binding]; other site
76869013581	DEAD/H associated; Region: DEAD_assoc; pfam08494
76869013582	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
76869013583	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
76869013584	active site
76869013585	FMN binding site [chemical binding]; other site
76869013586	substrate binding site [chemical binding]; other site
76869013587	3Fe-4S cluster binding site [ion binding]; other site
76869013588	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
76869013589	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
76869013590	Transglycosylase; Region: Transgly; pfam00912
76869013591	Predicted transcriptional regulators [Transcription]; Region: COG1695
76869013592	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
76869013593	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
76869013594	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
76869013595	FAD binding pocket [chemical binding]; other site
76869013596	FAD binding motif [chemical binding]; other site
76869013597	phosphate binding motif [ion binding]; other site
76869013598	NAD binding pocket [chemical binding]; other site
76869013599	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
76869013600	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
76869013601	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869013602	N-terminal plug; other site
76869013603	ligand-binding site [chemical binding]; other site
76869013604	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
76869013605	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
76869013606	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
76869013607	Trp docking motif [polypeptide binding]; other site
76869013608	putative active site [active]
76869013609	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
76869013610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869013611	Walker A motif; other site
76869013612	ATP binding site [chemical binding]; other site
76869013613	Walker B motif; other site
76869013614	arginine finger; other site
76869013615	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
76869013616	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
76869013617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869013618	active site
76869013619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869013620	S-adenosylmethionine binding site [chemical binding]; other site
76869013621	Methyltransferase domain; Region: Methyltransf_31; pfam13847
76869013622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869013623	S-adenosylmethionine binding site [chemical binding]; other site
76869013624	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
76869013625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013626	active site
76869013627	phosphorylation site [posttranslational modification]
76869013628	intermolecular recognition site; other site
76869013629	dimerization interface [polypeptide binding]; other site
76869013630	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869013631	DNA binding site [nucleotide binding]
76869013632	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
76869013633	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869013634	dimerization interface [polypeptide binding]; other site
76869013635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013636	dimer interface [polypeptide binding]; other site
76869013637	phosphorylation site [posttranslational modification]
76869013638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013639	ATP binding site [chemical binding]; other site
76869013640	Mg2+ binding site [ion binding]; other site
76869013641	G-X-G motif; other site
76869013642	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
76869013643	active site
76869013644	hydrophilic channel; other site
76869013645	dimerization interface [polypeptide binding]; other site
76869013646	catalytic residues [active]
76869013647	active site lid [active]
76869013648	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
76869013649	Recombination protein O N terminal; Region: RecO_N; pfam11967
76869013650	Recombination protein O C terminal; Region: RecO_C; pfam02565
76869013651	GTPase Era; Reviewed; Region: era; PRK00089
76869013652	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
76869013653	G1 box; other site
76869013654	GTP/Mg2+ binding site [chemical binding]; other site
76869013655	Switch I region; other site
76869013656	G2 box; other site
76869013657	Switch II region; other site
76869013658	G3 box; other site
76869013659	G4 box; other site
76869013660	G5 box; other site
76869013661	KH domain; Region: KH_2; pfam07650
76869013662	ribonuclease III; Reviewed; Region: rnc; PRK00102
76869013663	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
76869013664	dimerization interface [polypeptide binding]; other site
76869013665	active site
76869013666	metal binding site [ion binding]; metal-binding site
76869013667	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
76869013668	dsRNA binding site [nucleotide binding]; other site
76869013669	signal peptidase I; Provisional; Region: PRK10861
76869013670	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
76869013671	Catalytic site [active]
76869013672	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
76869013673	GTP-binding protein LepA; Provisional; Region: PRK05433
76869013674	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
76869013675	G1 box; other site
76869013676	putative GEF interaction site [polypeptide binding]; other site
76869013677	GTP/Mg2+ binding site [chemical binding]; other site
76869013678	Switch I region; other site
76869013679	G2 box; other site
76869013680	G3 box; other site
76869013681	Switch II region; other site
76869013682	G4 box; other site
76869013683	G5 box; other site
76869013684	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
76869013685	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
76869013686	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
76869013687	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
76869013688	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
76869013689	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
76869013690	protein binding site [polypeptide binding]; other site
76869013691	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
76869013692	protein binding site [polypeptide binding]; other site
76869013693	anti-sigma E factor; Provisional; Region: rseB; PRK09455
76869013694	MucB/RseB family; Region: MucB_RseB; pfam03888
76869013695	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
76869013696	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
76869013697	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
76869013698	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
76869013699	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869013700	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869013701	DNA binding residues [nucleotide binding]
76869013702	L-aspartate oxidase; Provisional; Region: PRK09077
76869013703	L-aspartate oxidase; Provisional; Region: PRK06175
76869013704	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
76869013705	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
76869013706	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869013707	active site
76869013708	DNA binding site [nucleotide binding]
76869013709	Int/Topo IB signature motif; other site
76869013710	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
76869013711	Uncharacterized conserved protein [Function unknown]; Region: COG2938
76869013712	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
76869013713	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
76869013714	HDOD domain; Region: HDOD; pfam08668
76869013715	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
76869013716	HAMP domain; Region: HAMP; pfam00672
76869013717	dimerization interface [polypeptide binding]; other site
76869013718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013719	dimer interface [polypeptide binding]; other site
76869013720	phosphorylation site [posttranslational modification]
76869013721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013722	ATP binding site [chemical binding]; other site
76869013723	Mg2+ binding site [ion binding]; other site
76869013724	G-X-G motif; other site
76869013725	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
76869013726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013727	active site
76869013728	phosphorylation site [posttranslational modification]
76869013729	intermolecular recognition site; other site
76869013730	dimerization interface [polypeptide binding]; other site
76869013731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869013732	DNA binding site [nucleotide binding]
76869013733	outer membrane porin, OprD family; Region: OprD; pfam03573
76869013734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
76869013735	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
76869013736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
76869013737	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
76869013738	Putative ammonia monooxygenase; Region: AmoA; pfam05145
76869013739	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
76869013740	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
76869013741	ligand binding site [chemical binding]; other site
76869013742	active site
76869013743	UGI interface [polypeptide binding]; other site
76869013744	catalytic site [active]
76869013745	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
76869013746	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
76869013747	substrate binding site [chemical binding]; other site
76869013748	oxyanion hole (OAH) forming residues; other site
76869013749	trimer interface [polypeptide binding]; other site
76869013750	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
76869013751	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869013752	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869013753	metal binding site [ion binding]; metal-binding site
76869013754	active site
76869013755	I-site; other site
76869013756	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
76869013757	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
76869013758	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
76869013759	active site
76869013760	uracil binding [chemical binding]; other site
76869013761	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869013762	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
76869013763	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
76869013764	Sulfate transporter family; Region: Sulfate_transp; pfam00916
76869013765	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
76869013766	Methyltransferase domain; Region: Methyltransf_31; pfam13847
76869013767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869013768	S-adenosylmethionine binding site [chemical binding]; other site
76869013769	Repair protein; Region: Repair_PSII; cl01535
76869013770	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
76869013771	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
76869013772	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
76869013773	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
76869013774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013775	dimer interface [polypeptide binding]; other site
76869013776	phosphorylation site [posttranslational modification]
76869013777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013778	ATP binding site [chemical binding]; other site
76869013779	Mg2+ binding site [ion binding]; other site
76869013780	G-X-G motif; other site
76869013781	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869013782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869013783	active site
76869013784	phosphorylation site [posttranslational modification]
76869013785	intermolecular recognition site; other site
76869013786	dimerization interface [polypeptide binding]; other site
76869013787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869013788	Walker A motif; other site
76869013789	ATP binding site [chemical binding]; other site
76869013790	Walker B motif; other site
76869013791	arginine finger; other site
76869013792	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869013793	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
76869013794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013795	putative substrate translocation pore; other site
76869013796	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869013797	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869013798	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869013799	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
76869013800	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
76869013801	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
76869013802	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
76869013803	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
76869013804	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869013805	hypothetical protein; Provisional; Region: PRK07524
76869013806	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869013807	PYR/PP interface [polypeptide binding]; other site
76869013808	dimer interface [polypeptide binding]; other site
76869013809	TPP binding site [chemical binding]; other site
76869013810	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869013811	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
76869013812	TPP-binding site [chemical binding]; other site
76869013813	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869013814	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013815	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
76869013816	substrate binding pocket [chemical binding]; other site
76869013817	dimerization interface [polypeptide binding]; other site
76869013818	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
76869013819	NADH(P)-binding; Region: NAD_binding_10; pfam13460
76869013820	NAD binding site [chemical binding]; other site
76869013821	substrate binding site [chemical binding]; other site
76869013822	putative active site [active]
76869013823	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
76869013824	transcriptional regulator; Provisional; Region: PRK10632
76869013825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013826	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869013827	putative effector binding pocket; other site
76869013828	dimerization interface [polypeptide binding]; other site
76869013829	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
76869013830	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
76869013831	tetramer interface [polypeptide binding]; other site
76869013832	active site
76869013833	Mg2+/Mn2+ binding site [ion binding]; other site
76869013834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013835	putative substrate translocation pore; other site
76869013836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013837	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
76869013838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869013839	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
76869013840	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869013841	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869013842	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869013843	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
76869013844	Protein export membrane protein; Region: SecD_SecF; cl14618
76869013845	Protein export membrane protein; Region: SecD_SecF; cl14618
76869013846	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
76869013847	outer membrane porin, OprD family; Region: OprD; pfam03573
76869013848	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869013849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013850	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869013851	dimerization interface [polypeptide binding]; other site
76869013852	Predicted membrane protein [Function unknown]; Region: COG4539
76869013853	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
76869013854	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
76869013855	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
76869013856	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
76869013857	tetramer interface [polypeptide binding]; other site
76869013858	active site
76869013859	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
76869013860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013861	putative substrate translocation pore; other site
76869013862	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
76869013863	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869013864	dimer interface [polypeptide binding]; other site
76869013865	active site
76869013866	benzoate transport; Region: 2A0115; TIGR00895
76869013867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013868	putative substrate translocation pore; other site
76869013869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869013870	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
76869013871	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
76869013872	Bacterial transcriptional regulator; Region: IclR; pfam01614
76869013873	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
76869013874	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
76869013875	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
76869013876	Cache domain; Region: Cache_1; pfam02743
76869013877	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869013878	dimerization interface [polypeptide binding]; other site
76869013879	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869013880	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869013881	dimer interface [polypeptide binding]; other site
76869013882	putative CheW interface [polypeptide binding]; other site
76869013883	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869013884	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
76869013885	Predicted deacetylase [General function prediction only]; Region: COG3233
76869013886	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
76869013887	putative active site [active]
76869013888	putative Zn binding site [ion binding]; other site
76869013889	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
76869013890	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
76869013891	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
76869013892	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
76869013893	putative active site [active]
76869013894	putative substrate binding site [chemical binding]; other site
76869013895	putative cosubstrate binding site; other site
76869013896	catalytic site [active]
76869013897	exonuclease I; Provisional; Region: sbcB; PRK11779
76869013898	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
76869013899	active site
76869013900	catalytic site [active]
76869013901	substrate binding site [chemical binding]; other site
76869013902	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
76869013903	PilZ domain; Region: PilZ; pfam07238
76869013904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
76869013905	pyruvate kinase; Provisional; Region: PRK05826
76869013906	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
76869013907	domain interfaces; other site
76869013908	active site
76869013909	hypothetical protein; Provisional; Region: PRK05713
76869013910	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869013911	catalytic loop [active]
76869013912	iron binding site [ion binding]; other site
76869013913	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
76869013914	FAD binding pocket [chemical binding]; other site
76869013915	FAD binding motif [chemical binding]; other site
76869013916	phosphate binding motif [ion binding]; other site
76869013917	beta-alpha-beta structure motif; other site
76869013918	NAD binding pocket [chemical binding]; other site
76869013919	putative fumarate hydratase; Provisional; Region: PRK15392
76869013920	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
76869013921	Fumarase C-terminus; Region: Fumerase_C; pfam05683
76869013922	Predicted amidohydrolase [General function prediction only]; Region: COG0388
76869013923	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
76869013924	putative active site [active]
76869013925	catalytic triad [active]
76869013926	putative dimer interface [polypeptide binding]; other site
76869013927	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869013928	Coenzyme A binding pocket [chemical binding]; other site
76869013929	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
76869013930	intracellular protease, PfpI family; Region: PfpI; TIGR01382
76869013931	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
76869013932	conserved cys residue [active]
76869013933	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
76869013934	PLD-like domain; Region: PLDc_2; pfam13091
76869013935	putative active site [active]
76869013936	catalytic site [active]
76869013937	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
76869013938	PLD-like domain; Region: PLDc_2; pfam13091
76869013939	putative active site [active]
76869013940	catalytic site [active]
76869013941	YceI-like domain; Region: YceI; pfam04264
76869013942	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
76869013943	Beta-lactamase; Region: Beta-lactamase; pfam00144
76869013944	Acyl-CoA dehydrogenase, middle domain; Region: Acyl-CoA_dh_M; pfam02770
76869013945	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
76869013946	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
76869013947	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
76869013948	putative acyl-acceptor binding pocket; other site
76869013949	Protein of unknown function, DUF479; Region: DUF479; cl01203
76869013950	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869013951	dimerization interface [polypeptide binding]; other site
76869013952	putative DNA binding site [nucleotide binding]; other site
76869013953	putative Zn2+ binding site [ion binding]; other site
76869013954	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
76869013955	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
76869013956	FMN binding site [chemical binding]; other site
76869013957	active site
76869013958	substrate binding site [chemical binding]; other site
76869013959	catalytic residue [active]
76869013960	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
76869013961	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
76869013962	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
76869013963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869013964	NAD(P) binding site [chemical binding]; other site
76869013965	active site
76869013966	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
76869013967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869013968	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869013969	dimerization interface [polypeptide binding]; other site
76869013970	LysE type translocator; Region: LysE; cl00565
76869013971	superoxide dismutase; Provisional; Region: PRK10543
76869013972	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
76869013973	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
76869013974	biofilm formation regulator HmsP; Provisional; Region: PRK11829
76869013975	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869013976	metal binding site [ion binding]; metal-binding site
76869013977	active site
76869013978	I-site; other site
76869013979	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869013980	Imelysin; Region: Peptidase_M75; cl09159
76869013981	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
76869013982	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
76869013983	Imelysin; Region: Peptidase_M75; cl09159
76869013984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
76869013985	multidrug efflux protein; Reviewed; Region: PRK09579
76869013986	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
76869013987	Methyltransferase domain; Region: Methyltransf_23; pfam13489
76869013988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869013989	S-adenosylmethionine binding site [chemical binding]; other site
76869013990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
76869013991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
76869013992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869013993	dimer interface [polypeptide binding]; other site
76869013994	phosphorylation site [posttranslational modification]
76869013995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869013996	ATP binding site [chemical binding]; other site
76869013997	Mg2+ binding site [ion binding]; other site
76869013998	G-X-G motif; other site
76869013999	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
76869014000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869014001	active site
76869014002	phosphorylation site [posttranslational modification]
76869014003	intermolecular recognition site; other site
76869014004	dimerization interface [polypeptide binding]; other site
76869014005	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869014006	DNA binding site [nucleotide binding]
76869014007	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
76869014008	active site
76869014009	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
76869014010	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
76869014011	ring oligomerisation interface [polypeptide binding]; other site
76869014012	ATP/Mg binding site [chemical binding]; other site
76869014013	stacking interactions; other site
76869014014	hinge regions; other site
76869014015	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
76869014016	oligomerisation interface [polypeptide binding]; other site
76869014017	mobile loop; other site
76869014018	roof hairpin; other site
76869014019	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
76869014020	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
76869014021	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
76869014022	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
76869014023	Protein of unknown function, DUF481; Region: DUF481; pfam04338
76869014024	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
76869014025	DNA binding site [nucleotide binding]
76869014026	active site
76869014027	muropeptide transporter; Validated; Region: ampG; cl17669
76869014028	muropeptide transporter; Validated; Region: ampG; cl17669
76869014029	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
76869014030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869014031	mechanosensitive channel MscS; Provisional; Region: PRK10334
76869014032	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869014033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
76869014034	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
76869014035	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
76869014036	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
76869014037	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
76869014038	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869014039	dimerization interface [polypeptide binding]; other site
76869014040	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
76869014041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869014042	putative active site [active]
76869014043	heme pocket [chemical binding]; other site
76869014044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869014045	dimer interface [polypeptide binding]; other site
76869014046	phosphorylation site [posttranslational modification]
76869014047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869014048	ATP binding site [chemical binding]; other site
76869014049	Mg2+ binding site [ion binding]; other site
76869014050	G-X-G motif; other site
76869014051	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
76869014052	hypothetical protein; Provisional; Region: PRK08999
76869014053	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
76869014054	active site
76869014055	8-oxo-dGMP binding site [chemical binding]; other site
76869014056	nudix motif; other site
76869014057	metal binding site [ion binding]; metal-binding site
76869014058	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
76869014059	thiamine phosphate binding site [chemical binding]; other site
76869014060	active site
76869014061	pyrophosphate binding site [ion binding]; other site
76869014062	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
76869014063	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
76869014064	putative C-terminal domain interface [polypeptide binding]; other site
76869014065	putative GSH binding site (G-site) [chemical binding]; other site
76869014066	putative dimer interface [polypeptide binding]; other site
76869014067	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
76869014068	putative substrate binding pocket (H-site) [chemical binding]; other site
76869014069	putative N-terminal domain interface [polypeptide binding]; other site
76869014070	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
76869014071	heterotetramer interface [polypeptide binding]; other site
76869014072	active site pocket [active]
76869014073	cleavage site
76869014074	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
76869014075	DEAD/DEAH box helicase; Region: DEAD; pfam00270
76869014076	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
76869014077	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
76869014078	nucleotide binding region [chemical binding]; other site
76869014079	ATP-binding site [chemical binding]; other site
76869014080	SEC-C motif; Region: SEC-C; pfam02810
76869014081	Protein of unknown function (DUF721); Region: DUF721; pfam05258
76869014082	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
76869014083	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
76869014084	cell division protein FtsZ; Validated; Region: PRK09330
76869014085	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
76869014086	nucleotide binding site [chemical binding]; other site
76869014087	SulA interaction site; other site
76869014088	cell division protein FtsA; Region: ftsA; TIGR01174
76869014089	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
76869014090	nucleotide binding site [chemical binding]; other site
76869014091	Cell division protein FtsA; Region: FtsA; pfam14450
76869014092	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
76869014093	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
76869014094	Cell division protein FtsQ; Region: FtsQ; pfam03799
76869014095	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
76869014096	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
76869014097	ATP-grasp domain; Region: ATP-grasp_4; cl17255
76869014098	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
76869014099	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
76869014100	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
76869014101	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
76869014102	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
76869014103	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
76869014104	active site
76869014105	homodimer interface [polypeptide binding]; other site
76869014106	cell division protein FtsW; Region: ftsW; TIGR02614
76869014107	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
76869014108	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
76869014109	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
76869014110	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
76869014111	Mg++ binding site [ion binding]; other site
76869014112	putative catalytic motif [active]
76869014113	putative substrate binding site [chemical binding]; other site
76869014114	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
76869014115	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
76869014116	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
76869014117	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
76869014118	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
76869014119	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
76869014120	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
76869014121	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
76869014122	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
76869014123	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
76869014124	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
76869014125	Cell division protein FtsL; Region: FtsL; pfam04999
76869014126	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
76869014127	MraW methylase family; Region: Methyltransf_5; cl17771
76869014128	cell division protein MraZ; Reviewed; Region: PRK00326
76869014129	MraZ protein; Region: MraZ; pfam02381
76869014130	MraZ protein; Region: MraZ; pfam02381
76869014131	Predicted methyltransferases [General function prediction only]; Region: COG0313
76869014132	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
76869014133	putative SAM binding site [chemical binding]; other site
76869014134	putative homodimer interface [polypeptide binding]; other site
76869014135	LppC putative lipoprotein; Region: LppC; pfam04348
76869014136	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
76869014137	putative ligand binding site [chemical binding]; other site
76869014138	hypothetical protein; Reviewed; Region: PRK12497
76869014139	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
76869014140	dimer interface [polypeptide binding]; other site
76869014141	active site
76869014142	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
76869014143	BON domain; Region: BON; pfam04972
76869014144	BON domain; Region: BON; pfam04972
76869014145	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
76869014146	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
76869014147	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
76869014148	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
76869014149	stringent starvation protein A; Provisional; Region: sspA; PRK09481
76869014150	C-terminal domain interface [polypeptide binding]; other site
76869014151	putative GSH binding site (G-site) [chemical binding]; other site
76869014152	dimer interface [polypeptide binding]; other site
76869014153	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
76869014154	dimer interface [polypeptide binding]; other site
76869014155	N-terminal domain interface [polypeptide binding]; other site
76869014156	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
76869014157	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
76869014158	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
76869014159	Qi binding site; other site
76869014160	intrachain domain interface; other site
76869014161	interchain domain interface [polypeptide binding]; other site
76869014162	heme bH binding site [chemical binding]; other site
76869014163	heme bL binding site [chemical binding]; other site
76869014164	Qo binding site; other site
76869014165	interchain domain interface [polypeptide binding]; other site
76869014166	intrachain domain interface; other site
76869014167	Qi binding site; other site
76869014168	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
76869014169	Qo binding site; other site
76869014170	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
76869014171	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
76869014172	[2Fe-2S] cluster binding site [ion binding]; other site
76869014173	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
76869014174	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
76869014175	23S rRNA interface [nucleotide binding]; other site
76869014176	L3 interface [polypeptide binding]; other site
76869014177	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869014178	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869014179	active site
76869014180	catalytic tetrad [active]
76869014181	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
76869014182	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
76869014183	conserved cys residue [active]
76869014184	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869014185	Predicted ATPase [General function prediction only]; Region: COG1485
76869014186	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
76869014187	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
76869014188	active site
76869014189	HIGH motif; other site
76869014190	dimer interface [polypeptide binding]; other site
76869014191	KMSKS motif; other site
76869014192	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
76869014193	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
76869014194	methionine gamma-lyase; Provisional; Region: PRK07503
76869014195	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
76869014196	homodimer interface [polypeptide binding]; other site
76869014197	substrate-cofactor binding pocket; other site
76869014198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869014199	catalytic residue [active]
76869014200	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869014201	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
76869014202	putative DNA binding site [nucleotide binding]; other site
76869014203	putative Zn2+ binding site [ion binding]; other site
76869014204	AsnC family; Region: AsnC_trans_reg; pfam01037
76869014205	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
76869014206	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
76869014207	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
76869014208	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
76869014209	CysD dimerization site [polypeptide binding]; other site
76869014210	G1 box; other site
76869014211	putative GEF interaction site [polypeptide binding]; other site
76869014212	GTP/Mg2+ binding site [chemical binding]; other site
76869014213	Switch I region; other site
76869014214	G2 box; other site
76869014215	G3 box; other site
76869014216	Switch II region; other site
76869014217	G4 box; other site
76869014218	G5 box; other site
76869014219	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
76869014220	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
76869014221	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
76869014222	ligand-binding site [chemical binding]; other site
76869014223	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
76869014224	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
76869014225	Active Sites [active]
76869014226	Uncharacterized conserved protein [Function unknown]; Region: COG0327
76869014227	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
76869014228	serine endoprotease; Provisional; Region: PRK10898
76869014229	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
76869014230	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
76869014231	protein binding site [polypeptide binding]; other site
76869014232	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869014233	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869014234	Walker A/P-loop; other site
76869014235	ATP binding site [chemical binding]; other site
76869014236	Q-loop/lid; other site
76869014237	ABC transporter signature motif; other site
76869014238	Walker B; other site
76869014239	D-loop; other site
76869014240	H-loop/switch region; other site
76869014241	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869014242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869014243	dimer interface [polypeptide binding]; other site
76869014244	conserved gate region; other site
76869014245	putative PBP binding loops; other site
76869014246	ABC-ATPase subunit interface; other site
76869014247	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
76869014248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869014249	conserved gate region; other site
76869014250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869014251	dimer interface [polypeptide binding]; other site
76869014252	ABC-ATPase subunit interface; other site
76869014253	putative PBP binding loops; other site
76869014254	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869014255	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869014256	substrate binding pocket [chemical binding]; other site
76869014257	membrane-bound complex binding site; other site
76869014258	hinge residues; other site
76869014259	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
76869014260	putative hydrolase; Provisional; Region: PRK11460
76869014261	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
76869014262	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
76869014263	ATP binding site [chemical binding]; other site
76869014264	Mg++ binding site [ion binding]; other site
76869014265	motif III; other site
76869014266	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869014267	nucleotide binding region [chemical binding]; other site
76869014268	ATP-binding site [chemical binding]; other site
76869014269	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
76869014270	MoaD interaction [polypeptide binding]; other site
76869014271	active site residues [active]
76869014272	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
76869014273	MoaE interaction surface [polypeptide binding]; other site
76869014274	MoeB interaction surface [polypeptide binding]; other site
76869014275	thiocarboxylated glycine; other site
76869014276	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
76869014277	trimer interface [polypeptide binding]; other site
76869014278	dimer interface [polypeptide binding]; other site
76869014279	putative active site [active]
76869014280	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
76869014281	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
76869014282	putative active site [active]
76869014283	PhoH-like protein; Region: PhoH; pfam02562
76869014284	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
76869014285	NodB motif; other site
76869014286	active site
76869014287	catalytic site [active]
76869014288	metal binding site [ion binding]; metal-binding site
76869014289	hypothetical protein; Validated; Region: PRK02101
76869014290	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
76869014291	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
76869014292	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
76869014293	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
76869014294	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
76869014295	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
76869014296	PilZ domain; Region: PilZ; pfam07238
76869014297	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869014298	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
76869014299	Sel1-like repeats; Region: SEL1; smart00671
76869014300	Right handed beta helix region; Region: Beta_helix; pfam13229
76869014301	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
76869014302	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
76869014303	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244
76869014304	active site
76869014305	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
76869014306	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
76869014307	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
76869014308	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
76869014309	Substrate binding site; other site
76869014310	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
76869014311	short chain dehydrogenase; Provisional; Region: PRK05693
76869014312	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
76869014313	NADP binding site [chemical binding]; other site
76869014314	active site
76869014315	steroid binding site; other site
76869014316	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
76869014317	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
76869014318	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869014319	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869014320	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
76869014321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869014322	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014324	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
76869014325	putative substrate binding pocket [chemical binding]; other site
76869014326	putative dimerization interface [polypeptide binding]; other site
76869014327	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
76869014328	Ligand Binding Site [chemical binding]; other site
76869014329	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
76869014330	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869014331	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869014332	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
76869014333	Fusaric acid resistance protein family; Region: FUSC; pfam04632
76869014334	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
76869014335	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
76869014336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014338	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
76869014339	putative effector binding pocket; other site
76869014340	dimerization interface [polypeptide binding]; other site
76869014341	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
76869014342	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
76869014343	dimerization interface [polypeptide binding]; other site
76869014344	ligand binding site [chemical binding]; other site
76869014345	NADP binding site [chemical binding]; other site
76869014346	catalytic site [active]
76869014347	EamA-like transporter family; Region: EamA; pfam00892
76869014348	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869014349	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869014350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869014351	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869014352	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
76869014353	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869014354	N-terminal plug; other site
76869014355	ligand-binding site [chemical binding]; other site
76869014356	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
76869014357	FecR protein; Region: FecR; pfam04773
76869014358	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
76869014359	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869014360	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869014361	DNA binding residues [nucleotide binding]
76869014362	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
76869014363	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
76869014364	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
76869014365	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
76869014366	Protein of unknown function (DUF3649); Region: DUF3649; pfam12365
76869014367	RNA polymerase sigma factor; Provisional; Region: PRK12528
76869014368	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869014369	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869014370	DNA binding residues [nucleotide binding]
76869014371	fec operon regulator FecR; Reviewed; Region: PRK09774
76869014372	FecR protein; Region: FecR; pfam04773
76869014373	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869014374	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
76869014375	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869014376	N-terminal plug; other site
76869014377	ligand-binding site [chemical binding]; other site
76869014378	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
76869014379	30S subunit binding site; other site
76869014380	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
76869014381	Predicted membrane protein [Function unknown]; Region: COG3223
76869014382	YebG protein; Region: YebG; pfam07130
76869014383	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
76869014384	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
76869014385	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
76869014386	NAD binding site [chemical binding]; other site
76869014387	Phe binding site; other site
76869014388	Uncharacterized conserved protein [Function unknown]; Region: COG2912
76869014389	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
76869014390	maleylacetoacetate isomerase; Region: maiA; TIGR01262
76869014391	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
76869014392	C-terminal domain interface [polypeptide binding]; other site
76869014393	GSH binding site (G-site) [chemical binding]; other site
76869014394	putative dimer interface [polypeptide binding]; other site
76869014395	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
76869014396	dimer interface [polypeptide binding]; other site
76869014397	N-terminal domain interface [polypeptide binding]; other site
76869014398	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
76869014399	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
76869014400	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
76869014401	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
76869014402	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
76869014403	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
76869014404	Transcriptional regulator [Transcription]; Region: IclR; COG1414
76869014405	Bacterial transcriptional regulator; Region: IclR; pfam01614
76869014406	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
76869014407	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
76869014408	NAD binding site [chemical binding]; other site
76869014409	homodimer interface [polypeptide binding]; other site
76869014410	active site
76869014411	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869014412	LrgB-like family; Region: LrgB; pfam04172
76869014413	LrgA family; Region: LrgA; pfam03788
76869014414	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014416	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
76869014417	putative dimerization interface [polypeptide binding]; other site
76869014418	flavodoxin; Provisional; Region: PRK05723
76869014419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869014420	PAS domain; Region: PAS_9; pfam13426
76869014421	putative active site [active]
76869014422	heme pocket [chemical binding]; other site
76869014423	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
76869014424	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
76869014425	DNA binding residues [nucleotide binding]
76869014426	B12 binding domain; Region: B12-binding_2; pfam02607
76869014427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
76869014428	dihydromonapterin reductase; Provisional; Region: PRK06483
76869014429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
76869014430	NAD(P) binding site [chemical binding]; other site
76869014431	active site
76869014432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
76869014433	HopJ type III effector protein; Region: HopJ; pfam08888
76869014434	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
76869014435	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869014436	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
76869014437	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
76869014438	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
76869014439	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
76869014440	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869014441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014442	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869014443	dimerization interface [polypeptide binding]; other site
76869014444	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
76869014445	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
76869014446	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
76869014447	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
76869014448	putative active site; other site
76869014449	catalytic triad [active]
76869014450	putative dimer interface [polypeptide binding]; other site
76869014451	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869014452	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869014453	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
76869014454	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
76869014455	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
76869014456	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
76869014457	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
76869014458	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
76869014459	dimer interface [polypeptide binding]; other site
76869014460	active site
76869014461	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
76869014462	classical (c) SDRs; Region: SDR_c; cd05233
76869014463	NAD(P) binding site [chemical binding]; other site
76869014464	active site
76869014465	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
76869014466	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
76869014467	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
76869014468	FAD binding site [chemical binding]; other site
76869014469	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
76869014470	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
76869014471	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
76869014472	P-loop, Walker A motif; other site
76869014473	Base recognition motif; other site
76869014474	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
76869014475	Protein of unknown function (DUF466); Region: DUF466; pfam04328
76869014476	carbon starvation protein A; Provisional; Region: PRK15015
76869014477	Carbon starvation protein CstA; Region: CstA; pfam02554
76869014478	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
76869014479	xanthine permease; Region: pbuX; TIGR03173
76869014480	DNA repair protein RadA; Provisional; Region: PRK11823
76869014481	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
76869014482	Walker A motif; other site
76869014483	ATP binding site [chemical binding]; other site
76869014484	Walker B motif; other site
76869014485	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
76869014486	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
76869014487	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
76869014488	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
76869014489	ferredoxin-NADP reductase; Provisional; Region: PRK10926
76869014490	FAD binding pocket [chemical binding]; other site
76869014491	FAD binding motif [chemical binding]; other site
76869014492	phosphate binding motif [ion binding]; other site
76869014493	beta-alpha-beta structure motif; other site
76869014494	NAD binding pocket [chemical binding]; other site
76869014495	Autoinducer binding domain; Region: Autoind_bind; pfam03472
76869014496	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
76869014497	DNA binding residues [nucleotide binding]
76869014498	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
76869014499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869014500	S-adenosylmethionine binding site [chemical binding]; other site
76869014501	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
76869014502	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
76869014503	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
76869014504	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
76869014505	H+ Antiporter protein; Region: 2A0121; TIGR00900
76869014506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869014507	putative substrate translocation pore; other site
76869014508	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
76869014509	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
76869014510	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
76869014511	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
76869014512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869014513	S-adenosylmethionine binding site [chemical binding]; other site
76869014514	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
76869014515	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
76869014516	heterodimer interface [polypeptide binding]; other site
76869014517	active site
76869014518	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
76869014519	heterodimer interface [polypeptide binding]; other site
76869014520	multimer interface [polypeptide binding]; other site
76869014521	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
76869014522	active site
76869014523	Predicted metalloprotease [General function prediction only]; Region: COG2321
76869014524	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
76869014525	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869014526	dimerization interface [polypeptide binding]; other site
76869014527	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869014528	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869014529	dimer interface [polypeptide binding]; other site
76869014530	putative CheW interface [polypeptide binding]; other site
76869014531	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
76869014532	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
76869014533	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014535	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869014536	dimerization interface [polypeptide binding]; other site
76869014537	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
76869014538	Uncharacterized conserved protein [Function unknown]; Region: COG1359
76869014539	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014540	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014541	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869014542	dimerization interface [polypeptide binding]; other site
76869014543	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
76869014544	Protein of unknown function (DUF796); Region: DUF796; pfam05638
76869014545	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
76869014546	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
76869014547	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
76869014548	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
76869014549	tetrameric interface [polypeptide binding]; other site
76869014550	NAD binding site [chemical binding]; other site
76869014551	catalytic residues [active]
76869014552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014554	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869014555	dimerization interface [polypeptide binding]; other site
76869014556	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
76869014557	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869014558	ligand binding site [chemical binding]; other site
76869014559	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
76869014560	HAMP domain; Region: HAMP; pfam00672
76869014561	dimerization interface [polypeptide binding]; other site
76869014562	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869014563	metal binding site [ion binding]; metal-binding site
76869014564	active site
76869014565	I-site; other site
76869014566	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
76869014567	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
76869014568	AAA domain; Region: AAA_30; pfam13604
76869014569	Family description; Region: UvrD_C_2; pfam13538
76869014570	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
76869014571	Family description; Region: UvrD_C_2; pfam13538
76869014572	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
76869014573	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
76869014574	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
76869014575	TMAO/DMSO reductase; Reviewed; Region: PRK05363
76869014576	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
76869014577	Moco binding site; other site
76869014578	metal coordination site [ion binding]; other site
76869014579	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
76869014580	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
76869014581	ketol-acid reductoisomerase; Provisional; Region: PRK05479
76869014582	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
76869014583	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
76869014584	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
76869014585	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
76869014586	putative valine binding site [chemical binding]; other site
76869014587	dimer interface [polypeptide binding]; other site
76869014588	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
76869014589	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
76869014590	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
76869014591	PYR/PP interface [polypeptide binding]; other site
76869014592	dimer interface [polypeptide binding]; other site
76869014593	TPP binding site [chemical binding]; other site
76869014594	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
76869014595	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
76869014596	TPP-binding site [chemical binding]; other site
76869014597	dimer interface [polypeptide binding]; other site
76869014598	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
76869014599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
76869014600	TPR motif; other site
76869014601	binding surface
76869014602	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
76869014603	Transglycosylase; Region: Transgly; pfam00912
76869014604	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
76869014605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
76869014606	Predicted kinase [General function prediction only]; Region: COG0645
76869014607	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
76869014608	ATP-binding site [chemical binding]; other site
76869014609	Gluconate-6-phosphate binding site [chemical binding]; other site
76869014610	TfoX C-terminal domain; Region: TfoX_C; pfam04994
76869014611	Protein of unknown function, DUF399; Region: DUF399; cl01139
76869014612	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
76869014613	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
76869014614	Walker A/P-loop; other site
76869014615	ATP binding site [chemical binding]; other site
76869014616	Q-loop/lid; other site
76869014617	ABC transporter signature motif; other site
76869014618	Walker B; other site
76869014619	D-loop; other site
76869014620	H-loop/switch region; other site
76869014621	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
76869014622	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
76869014623	ABC-ATPase subunit  interface; other site
76869014624	dimer interface [polypeptide binding]; other site
76869014625	putative PBP binding regions; other site
76869014626	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
76869014627	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
76869014628	intersubunit interface [polypeptide binding]; other site
76869014629	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
76869014630	iron-sulfur cluster [ion binding]; other site
76869014631	[2Fe-2S] cluster binding site [ion binding]; other site
76869014632	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
76869014633	hypothetical protein; Provisional; Region: PRK08960
76869014634	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869014635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869014636	homodimer interface [polypeptide binding]; other site
76869014637	catalytic residue [active]
76869014638	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
76869014639	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
76869014640	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
76869014641	active site
76869014642	HIGH motif; other site
76869014643	nucleotide binding site [chemical binding]; other site
76869014644	active site
76869014645	KMSKS motif; other site
76869014646	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
76869014647	Na binding site [ion binding]; other site
76869014648	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
76869014649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869014650	putative active site [active]
76869014651	heme pocket [chemical binding]; other site
76869014652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869014653	dimer interface [polypeptide binding]; other site
76869014654	phosphorylation site [posttranslational modification]
76869014655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869014656	ATP binding site [chemical binding]; other site
76869014657	Mg2+ binding site [ion binding]; other site
76869014658	G-X-G motif; other site
76869014659	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
76869014660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869014661	active site
76869014662	phosphorylation site [posttranslational modification]
76869014663	intermolecular recognition site; other site
76869014664	dimerization interface [polypeptide binding]; other site
76869014665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869014666	Walker A motif; other site
76869014667	ATP binding site [chemical binding]; other site
76869014668	Walker B motif; other site
76869014669	arginine finger; other site
76869014670	poly(A) polymerase; Region: pcnB; TIGR01942
76869014671	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
76869014672	active site
76869014673	NTP binding site [chemical binding]; other site
76869014674	metal binding triad [ion binding]; metal-binding site
76869014675	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
76869014676	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
76869014677	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
76869014678	catalytic center binding site [active]
76869014679	ATP binding site [chemical binding]; other site
76869014680	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
76869014681	oligomerization interface [polypeptide binding]; other site
76869014682	active site
76869014683	metal binding site [ion binding]; metal-binding site
76869014684	Pantoate-beta-alanine ligase; Region: PanC; cd00560
76869014685	pantoate--beta-alanine ligase; Region: panC; TIGR00018
76869014686	active site
76869014687	ATP-binding site [chemical binding]; other site
76869014688	pantoate-binding site; other site
76869014689	HXXH motif; other site
76869014690	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
76869014691	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
76869014692	active site
76869014693	dimer interface [polypeptide binding]; other site
76869014694	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
76869014695	dimer interface [polypeptide binding]; other site
76869014696	active site
76869014697	acetyl-CoA synthetase; Provisional; Region: PRK00174
76869014698	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
76869014699	active site
76869014700	CoA binding site [chemical binding]; other site
76869014701	acyl-activating enzyme (AAE) consensus motif; other site
76869014702	AMP binding site [chemical binding]; other site
76869014703	acetate binding site [chemical binding]; other site
76869014704	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
76869014705	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
76869014706	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
76869014707	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
76869014708	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
76869014709	ligand binding site [chemical binding]; other site
76869014710	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
76869014711	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
76869014712	active site
76869014713	metal binding site [ion binding]; metal-binding site
76869014714	Uncharacterized conserved protein [Function unknown]; Region: COG1359
76869014715	BON domain; Region: BON; pfam04972
76869014716	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
76869014717	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
76869014718	RNase E interface [polypeptide binding]; other site
76869014719	trimer interface [polypeptide binding]; other site
76869014720	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
76869014721	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
76869014722	RNase E interface [polypeptide binding]; other site
76869014723	trimer interface [polypeptide binding]; other site
76869014724	active site
76869014725	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
76869014726	putative nucleic acid binding region [nucleotide binding]; other site
76869014727	G-X-X-G motif; other site
76869014728	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
76869014729	RNA binding site [nucleotide binding]; other site
76869014730	domain interface; other site
76869014731	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
76869014732	16S/18S rRNA binding site [nucleotide binding]; other site
76869014733	S13e-L30e interaction site [polypeptide binding]; other site
76869014734	25S rRNA binding site [nucleotide binding]; other site
76869014735	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
76869014736	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
76869014737	RNA binding site [nucleotide binding]; other site
76869014738	active site
76869014739	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
76869014740	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
76869014741	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
76869014742	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
76869014743	translation initiation factor IF-2; Region: IF-2; TIGR00487
76869014744	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
76869014745	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
76869014746	G1 box; other site
76869014747	putative GEF interaction site [polypeptide binding]; other site
76869014748	GTP/Mg2+ binding site [chemical binding]; other site
76869014749	Switch I region; other site
76869014750	G2 box; other site
76869014751	G3 box; other site
76869014752	Switch II region; other site
76869014753	G4 box; other site
76869014754	G5 box; other site
76869014755	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
76869014756	Translation-initiation factor 2; Region: IF-2; pfam11987
76869014757	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
76869014758	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
76869014759	NusA N-terminal domain; Region: NusA_N; pfam08529
76869014760	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
76869014761	RNA binding site [nucleotide binding]; other site
76869014762	homodimer interface [polypeptide binding]; other site
76869014763	NusA-like KH domain; Region: KH_5; pfam13184
76869014764	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
76869014765	G-X-X-G motif; other site
76869014766	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
76869014767	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
76869014768	ribosome maturation protein RimP; Reviewed; Region: PRK00092
76869014769	Sm and related proteins; Region: Sm_like; cl00259
76869014770	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
76869014771	putative oligomer interface [polypeptide binding]; other site
76869014772	putative RNA binding site [nucleotide binding]; other site
76869014773	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
76869014774	triosephosphate isomerase; Provisional; Region: PRK14567
76869014775	substrate binding site [chemical binding]; other site
76869014776	dimer interface [polypeptide binding]; other site
76869014777	catalytic triad [active]
76869014778	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
76869014779	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
76869014780	active site
76869014781	substrate binding site [chemical binding]; other site
76869014782	metal binding site [ion binding]; metal-binding site
76869014783	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
76869014784	dihydropteroate synthase; Region: DHPS; TIGR01496
76869014785	substrate binding pocket [chemical binding]; other site
76869014786	dimer interface [polypeptide binding]; other site
76869014787	inhibitor binding site; inhibition site
76869014788	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
76869014789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869014790	Walker A motif; other site
76869014791	ATP binding site [chemical binding]; other site
76869014792	Walker B motif; other site
76869014793	arginine finger; other site
76869014794	Peptidase family M41; Region: Peptidase_M41; pfam01434
76869014795	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
76869014796	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869014797	S-adenosylmethionine binding site [chemical binding]; other site
76869014798	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
76869014799	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
76869014800	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
76869014801	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
76869014802	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
76869014803	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
76869014804	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
76869014805	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
76869014806	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
76869014807	ATP-grasp domain; Region: ATP-grasp_4; cl17255
76869014808	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
76869014809	IMP binding site; other site
76869014810	dimer interface [polypeptide binding]; other site
76869014811	interdomain contacts; other site
76869014812	partial ornithine binding site; other site
76869014813	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
76869014814	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
76869014815	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
76869014816	catalytic site [active]
76869014817	subunit interface [polypeptide binding]; other site
76869014818	dihydrodipicolinate reductase; Provisional; Region: PRK00048
76869014819	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
76869014820	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
76869014821	chaperone protein DnaJ; Provisional; Region: PRK10767
76869014822	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
76869014823	HSP70 interaction site [polypeptide binding]; other site
76869014824	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
76869014825	substrate binding site [polypeptide binding]; other site
76869014826	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
76869014827	Zn binding sites [ion binding]; other site
76869014828	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
76869014829	dimer interface [polypeptide binding]; other site
76869014830	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
76869014831	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
76869014832	nucleotide binding site [chemical binding]; other site
76869014833	NEF interaction site [polypeptide binding]; other site
76869014834	SBD interface [polypeptide binding]; other site
76869014835	GrpE; Region: GrpE; pfam01025
76869014836	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
76869014837	dimer interface [polypeptide binding]; other site
76869014838	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
76869014839	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
76869014840	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
76869014841	Walker A/P-loop; other site
76869014842	ATP binding site [chemical binding]; other site
76869014843	Q-loop/lid; other site
76869014844	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
76869014845	ABC transporter signature motif; other site
76869014846	Walker B; other site
76869014847	D-loop; other site
76869014848	H-loop/switch region; other site
76869014849	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
76869014850	metal binding site 2 [ion binding]; metal-binding site
76869014851	putative DNA binding helix; other site
76869014852	metal binding site 1 [ion binding]; metal-binding site
76869014853	dimer interface [polypeptide binding]; other site
76869014854	structural Zn2+ binding site [ion binding]; other site
76869014855	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
76869014856	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
76869014857	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
76869014858	putative coenzyme Q binding site [chemical binding]; other site
76869014859	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
76869014860	SmpB-tmRNA interface; other site
76869014861	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
76869014862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869014863	DNA-binding site [nucleotide binding]; DNA binding site
76869014864	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869014865	glycolate transporter; Provisional; Region: PRK09695
76869014866	L-lactate permease; Region: Lactate_perm; cl00701
76869014867	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
76869014868	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
76869014869	phosphate binding site [ion binding]; other site
76869014870	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
76869014871	FAD binding domain; Region: FAD_binding_4; pfam01565
76869014872	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
76869014873	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
76869014874	integrase; Provisional; Region: PRK09692
76869014875	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
76869014876	active site
76869014877	Int/Topo IB signature motif; other site
76869014878	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
76869014879	putative phage-type endonuclease; Region: phage_rel_nuc; TIGR03033
76869014880	hypothetical protein; Reviewed; Region: PRK00024
76869014881	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
76869014882	MPN+ (JAMM) motif; other site
76869014883	Zinc-binding site [ion binding]; other site
76869014884	EcoRII C terminal; Region: EcoRII-C; pfam09019
76869014885	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
76869014886	additional DNA contacts [nucleotide binding]; other site
76869014887	mismatch recognition site; other site
76869014888	active site
76869014889	zinc binding site [ion binding]; other site
76869014890	DNA intercalation site [nucleotide binding]; other site
76869014891	DNA cytosine methylase; Provisional; Region: PRK10458
76869014892	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
76869014893	cofactor binding site; other site
76869014894	DNA binding site [nucleotide binding]
76869014895	substrate interaction site [chemical binding]; other site
76869014896	Transposase domain (DUF772); Region: DUF772; pfam05598
76869014897	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
76869014898	active site
76869014899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869014900	ATP binding site [chemical binding]; other site
76869014901	Mg2+ binding site [ion binding]; other site
76869014902	G-X-G motif; other site
76869014903	N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016
76869014904	DNA binding site [nucleotide binding]
76869014905	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
76869014906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869014907	ATP binding site [chemical binding]; other site
76869014908	putative Mg++ binding site [ion binding]; other site
76869014909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869014910	nucleotide binding region [chemical binding]; other site
76869014911	ATP-binding site [chemical binding]; other site
76869014912	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
76869014913	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
76869014914	Protein of unknown function (DUF726); Region: DUF726; pfam05277
76869014915	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
76869014916	G2 box; other site
76869014917	Switch I region; other site
76869014918	G3 box; other site
76869014919	Switch II region; other site
76869014920	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
76869014921	G1 box; other site
76869014922	GTP/Mg2+ binding site [chemical binding]; other site
76869014923	G2 box; other site
76869014924	Switch I region; other site
76869014925	G3 box; other site
76869014926	Switch II region; other site
76869014927	G4 box; other site
76869014928	G5 box; other site
76869014929	WYL domain; Region: WYL; pfam13280
76869014930	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869014931	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
76869014932	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869014933	N-terminal plug; other site
76869014934	ligand-binding site [chemical binding]; other site
76869014935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869014936	putative substrate translocation pore; other site
76869014937	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869014938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869014939	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
76869014940	dimerization interface [polypeptide binding]; other site
76869014941	substrate binding pocket [chemical binding]; other site
76869014942	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
76869014943	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
76869014944	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
76869014945	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
76869014946	active site
76869014947	tetramer interface [polypeptide binding]; other site
76869014948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869014949	D-galactonate transporter; Region: 2A0114; TIGR00893
76869014950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869014951	Transcriptional regulators [Transcription]; Region: FadR; COG2186
76869014952	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869014953	DNA-binding site [nucleotide binding]; DNA binding site
76869014954	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
76869014955	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
76869014956	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
76869014957	Walker A/P-loop; other site
76869014958	ATP binding site [chemical binding]; other site
76869014959	Q-loop/lid; other site
76869014960	ABC transporter signature motif; other site
76869014961	Walker B; other site
76869014962	D-loop; other site
76869014963	H-loop/switch region; other site
76869014964	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
76869014965	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
76869014966	ABC-ATPase subunit  interface; other site
76869014967	dimer interface [polypeptide binding]; other site
76869014968	putative PBP binding regions; other site
76869014969	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
76869014970	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
76869014971	intersubunit interface [polypeptide binding]; other site
76869014972	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
76869014973	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
76869014974	putative NAD(P) binding site [chemical binding]; other site
76869014975	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
76869014976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869014977	active site
76869014978	motif I; other site
76869014979	motif II; other site
76869014980	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
76869014981	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
76869014982	active site
76869014983	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
76869014984	catalytic triad [active]
76869014985	dimer interface [polypeptide binding]; other site
76869014986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
76869014987	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
76869014988	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
76869014989	catalytic core [active]
76869014990	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
76869014991	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
76869014992	putative active site [active]
76869014993	Zn binding site [ion binding]; other site
76869014994	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
76869014995	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
76869014996	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
76869014997	ATP binding site [chemical binding]; other site
76869014998	Mg++ binding site [ion binding]; other site
76869014999	motif III; other site
76869015000	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869015001	nucleotide binding region [chemical binding]; other site
76869015002	ATP-binding site [chemical binding]; other site
76869015003	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
76869015004	EamA-like transporter family; Region: EamA; pfam00892
76869015005	EamA-like transporter family; Region: EamA; pfam00892
76869015006	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
76869015007	active site
76869015008	catalytic site [active]
76869015009	substrate binding site [chemical binding]; other site
76869015010	Uncharacterized conserved protein [Function unknown]; Region: COG1432
76869015011	LabA_like proteins; Region: LabA; cd10911
76869015012	putative metal binding site [ion binding]; other site
76869015013	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
76869015014	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
76869015015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869015016	nucleotide binding region [chemical binding]; other site
76869015017	ATP-binding site [chemical binding]; other site
76869015018	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
76869015019	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
76869015020	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869015021	active site
76869015022	catalytic residues [active]
76869015023	DNA binding site [nucleotide binding]
76869015024	Int/Topo IB signature motif; other site
76869015025	PBC domain; Region: PBC; pfam03792
76869015026	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
76869015027	active site
76869015028	catalytic residues [active]
76869015029	DNA binding site [nucleotide binding]
76869015030	Int/Topo IB signature motif; other site
76869015031	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
76869015032	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
76869015033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
76869015034	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
76869015035	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
76869015036	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
76869015037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
76869015038	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
76869015039	RES domain; Region: RES; pfam08808
76869015040	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
76869015041	Y-family of DNA polymerases; Region: PolY; cl12025
76869015042	Protein of unknown function DUF262; Region: DUF262; pfam03235
76869015043	Uncharacterized conserved protein [Function unknown]; Region: COG1479
76869015044	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
76869015045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
76869015046	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
76869015047	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
76869015048	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869015049	sequence-specific DNA binding site [nucleotide binding]; other site
76869015050	salt bridge; other site
76869015051	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
76869015052	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
76869015053	active site
76869015054	metal binding site [ion binding]; metal-binding site
76869015055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869015056	non-specific DNA binding site [nucleotide binding]; other site
76869015057	salt bridge; other site
76869015058	sequence-specific DNA binding site [nucleotide binding]; other site
76869015059	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
76869015060	DNA-binding interface [nucleotide binding]; DNA binding site
76869015061	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
76869015062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869015063	ATP binding site [chemical binding]; other site
76869015064	putative Mg++ binding site [ion binding]; other site
76869015065	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869015066	nucleotide binding region [chemical binding]; other site
76869015067	ATP-binding site [chemical binding]; other site
76869015068	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
76869015069	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
76869015070	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
76869015071	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
76869015072	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
76869015073	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
76869015074	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
76869015075	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
76869015076	PAS domain; Region: PAS_9; pfam13426
76869015077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869015078	putative active site [active]
76869015079	heme pocket [chemical binding]; other site
76869015080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869015081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869015082	metal binding site [ion binding]; metal-binding site
76869015083	active site
76869015084	I-site; other site
76869015085	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869015086	Transposase domain (DUF772); Region: DUF772; pfam05598
76869015087	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
76869015088	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
76869015089	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
76869015090	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
76869015091	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
76869015092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869015093	ATP binding site [chemical binding]; other site
76869015094	putative Mg++ binding site [ion binding]; other site
76869015095	Cation efflux family; Region: Cation_efflux; cl00316
76869015096	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
76869015097	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869015098	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869015099	putative DNA binding site [nucleotide binding]; other site
76869015100	putative Zn2+ binding site [ion binding]; other site
76869015101	AsnC family; Region: AsnC_trans_reg; pfam01037
76869015102	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
76869015103	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
76869015104	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
76869015105	active site
76869015106	AMP nucleosidase; Provisional; Region: PRK08292
76869015107	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
76869015108	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
76869015109	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869015110	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
76869015111	active site
76869015112	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
76869015113	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
76869015114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869015115	dimer interface [polypeptide binding]; other site
76869015116	phosphorylation site [posttranslational modification]
76869015117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869015118	ATP binding site [chemical binding]; other site
76869015119	Mg2+ binding site [ion binding]; other site
76869015120	G-X-G motif; other site
76869015121	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
76869015122	dimer interface [polypeptide binding]; other site
76869015123	substrate binding site [chemical binding]; other site
76869015124	ATP binding site [chemical binding]; other site
76869015125	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
76869015126	thiamine phosphate binding site [chemical binding]; other site
76869015127	active site
76869015128	pyrophosphate binding site [ion binding]; other site
76869015129	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
76869015130	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869015131	inhibitor-cofactor binding pocket; inhibition site
76869015132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869015133	catalytic residue [active]
76869015134	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
76869015135	Sel1-like repeats; Region: SEL1; smart00671
76869015136	Sel1-like repeats; Region: SEL1; smart00671
76869015137	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
76869015138	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
76869015139	PhoH-like protein; Region: PhoH; pfam02562
76869015140	metal-binding heat shock protein; Provisional; Region: PRK00016
76869015141	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
76869015142	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
76869015143	Transporter associated domain; Region: CorC_HlyC; smart01091
76869015144	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
76869015145	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
76869015146	putative active site [active]
76869015147	catalytic triad [active]
76869015148	putative dimer interface [polypeptide binding]; other site
76869015149	Uncharacterized conserved protein [Function unknown]; Region: COG1434
76869015150	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
76869015151	putative active site [active]
76869015152	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
76869015153	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
76869015154	HIGH motif; other site
76869015155	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
76869015156	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
76869015157	active site
76869015158	KMSKS motif; other site
76869015159	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
76869015160	tRNA binding surface [nucleotide binding]; other site
76869015161	Lipopolysaccharide-assembly; Region: LptE; cl01125
76869015162	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
76869015163	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
76869015164	Domain of unknown function; Region: DUF331; cl01149
76869015165	Transglycosylase SLT domain; Region: SLT_2; pfam13406
76869015166	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869015167	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869015168	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
76869015169	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
76869015170	dimer interface [polypeptide binding]; other site
76869015171	catalytic triad [active]
76869015172	lipoyl synthase; Provisional; Region: PRK05481
76869015173	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869015174	FeS/SAM binding site; other site
76869015175	lipoate-protein ligase B; Provisional; Region: PRK14342
76869015176	hypothetical protein; Provisional; Region: PRK00341
76869015177	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
76869015178	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
76869015179	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
76869015180	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
76869015181	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
76869015182	Sporulation related domain; Region: SPOR; pfam05036
76869015183	Transglycosylase SLT domain; Region: SLT_2; pfam13406
76869015184	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
76869015185	N-acetyl-D-glucosamine binding site [chemical binding]; other site
76869015186	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
76869015187	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
76869015188	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
76869015189	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
76869015190	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
76869015191	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
76869015192	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
76869015193	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
76869015194	active site
76869015195	(T/H)XGH motif; other site
76869015196	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
76869015197	putative catalytic cysteine [active]
76869015198	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
76869015199	active site
76869015200	DNA binding site [nucleotide binding]
76869015201	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
76869015202	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
76869015203	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
76869015204	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
76869015205	active site
76869015206	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
76869015207	LrgB-like family; Region: LrgB; pfam04172
76869015208	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
76869015209	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
76869015210	putative active site [active]
76869015211	putative catalytic site [active]
76869015212	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
76869015213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
76869015214	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
76869015215	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
76869015216	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
76869015217	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
76869015218	FMN binding site [chemical binding]; other site
76869015219	active site
76869015220	catalytic residues [active]
76869015221	substrate binding site [chemical binding]; other site
76869015222	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
76869015223	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
76869015224	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
76869015225	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
76869015226	purine monophosphate binding site [chemical binding]; other site
76869015227	dimer interface [polypeptide binding]; other site
76869015228	putative catalytic residues [active]
76869015229	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
76869015230	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
76869015231	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
76869015232	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
76869015233	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
76869015234	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
76869015235	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
76869015236	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
76869015237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869015238	dimer interface [polypeptide binding]; other site
76869015239	phosphorylation site [posttranslational modification]
76869015240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869015241	ATP binding site [chemical binding]; other site
76869015242	Mg2+ binding site [ion binding]; other site
76869015243	G-X-G motif; other site
76869015244	Response regulator receiver domain; Region: Response_reg; pfam00072
76869015245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015246	active site
76869015247	phosphorylation site [posttranslational modification]
76869015248	intermolecular recognition site; other site
76869015249	dimerization interface [polypeptide binding]; other site
76869015250	Response regulator receiver domain; Region: Response_reg; pfam00072
76869015251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015252	active site
76869015253	phosphorylation site [posttranslational modification]
76869015254	intermolecular recognition site; other site
76869015255	dimerization interface [polypeptide binding]; other site
76869015256	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
76869015257	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
76869015258	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
76869015259	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
76869015260	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
76869015261	active site
76869015262	SAM binding site [chemical binding]; other site
76869015263	homodimer interface [polypeptide binding]; other site
76869015264	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
76869015265	homodimer interface [polypeptide binding]; other site
76869015266	active site
76869015267	SAM binding site [chemical binding]; other site
76869015268	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
76869015269	Precorrin-8X methylmutase; Region: CbiC; pfam02570
76869015270	precorrin-3B synthase; Region: CobG; TIGR02435
76869015271	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
76869015272	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
76869015273	active site
76869015274	putative homodimer interface [polypeptide binding]; other site
76869015275	SAM binding site [chemical binding]; other site
76869015276	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
76869015277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869015278	S-adenosylmethionine binding site [chemical binding]; other site
76869015279	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
76869015280	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
76869015281	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
76869015282	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
76869015283	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
76869015284	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
76869015285	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
76869015286	Protein of unknown function (DUF461); Region: DUF461; pfam04314
76869015287	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
76869015288	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
76869015289	N-terminal plug; other site
76869015290	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
76869015291	ligand-binding site [chemical binding]; other site
76869015292	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
76869015293	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
76869015294	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
76869015295	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
76869015296	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
76869015297	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
76869015298	Spore germination protein; Region: Spore_permease; cl17796
76869015299	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582
76869015300	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
76869015301	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
76869015302	putative ligand binding site [chemical binding]; other site
76869015303	HEAT repeats; Region: HEAT_2; pfam13646
76869015304	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
76869015305	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
76869015306	TM-ABC transporter signature motif; other site
76869015307	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
76869015308	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
76869015309	TM-ABC transporter signature motif; other site
76869015310	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
76869015311	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
76869015312	Walker A/P-loop; other site
76869015313	ATP binding site [chemical binding]; other site
76869015314	Q-loop/lid; other site
76869015315	ABC transporter signature motif; other site
76869015316	Walker B; other site
76869015317	D-loop; other site
76869015318	H-loop/switch region; other site
76869015319	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
76869015320	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
76869015321	Walker A/P-loop; other site
76869015322	ATP binding site [chemical binding]; other site
76869015323	Q-loop/lid; other site
76869015324	ABC transporter signature motif; other site
76869015325	Walker B; other site
76869015326	D-loop; other site
76869015327	H-loop/switch region; other site
76869015328	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
76869015329	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869015330	Coenzyme A binding pocket [chemical binding]; other site
76869015331	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
76869015332	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
76869015333	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
76869015334	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
76869015335	HSP70 interaction site [polypeptide binding]; other site
76869015336	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
76869015337	substrate binding site [polypeptide binding]; other site
76869015338	dimer interface [polypeptide binding]; other site
76869015339	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
76869015340	putative chaperone; Provisional; Region: PRK11678
76869015341	nucleotide binding site [chemical binding]; other site
76869015342	putative NEF/HSP70 interaction site [polypeptide binding]; other site
76869015343	SBD interface [polypeptide binding]; other site
76869015344	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
76869015345	hypothetical protein; Provisional; Region: PRK11505
76869015346	psiF repeat; Region: PsiF_repeat; pfam07769
76869015347	psiF repeat; Region: PsiF_repeat; pfam07769
76869015348	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
76869015349	Helix-turn-helix domain; Region: HTH_18; pfam12833
76869015350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
76869015351	EamA-like transporter family; Region: EamA; pfam00892
76869015352	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
76869015353	EamA-like transporter family; Region: EamA; pfam00892
76869015354	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
76869015355	Lipase (class 2); Region: Lipase_2; pfam01674
76869015356	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
76869015357	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
76869015358	Ferritin-like domain; Region: Ferritin; pfam00210
76869015359	dinuclear metal binding motif [ion binding]; other site
76869015360	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
76869015361	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
76869015362	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
76869015363	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
76869015364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869015365	dimerization interface [polypeptide binding]; other site
76869015366	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
76869015367	putative active cleft [active]
76869015368	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
76869015369	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
76869015370	putative NAD(P) binding site [chemical binding]; other site
76869015371	homotetramer interface [polypeptide binding]; other site
76869015372	homodimer interface [polypeptide binding]; other site
76869015373	active site
76869015374	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
76869015375	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
76869015376	Walker A/P-loop; other site
76869015377	ATP binding site [chemical binding]; other site
76869015378	Q-loop/lid; other site
76869015379	ABC transporter signature motif; other site
76869015380	Walker B; other site
76869015381	D-loop; other site
76869015382	H-loop/switch region; other site
76869015383	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
76869015384	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
76869015385	Walker A/P-loop; other site
76869015386	ATP binding site [chemical binding]; other site
76869015387	Q-loop/lid; other site
76869015388	ABC transporter signature motif; other site
76869015389	Walker B; other site
76869015390	D-loop; other site
76869015391	H-loop/switch region; other site
76869015392	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
76869015393	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
76869015394	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
76869015395	TM-ABC transporter signature motif; other site
76869015396	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
76869015397	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
76869015398	TM-ABC transporter signature motif; other site
76869015399	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
76869015400	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
76869015401	dimerization interface [polypeptide binding]; other site
76869015402	ligand binding site [chemical binding]; other site
76869015403	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
76869015404	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
76869015405	active site
76869015406	NAD+ synthetase; Region: nadE; TIGR00552
76869015407	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
76869015408	homodimer interface [polypeptide binding]; other site
76869015409	NAD binding pocket [chemical binding]; other site
76869015410	ATP binding pocket [chemical binding]; other site
76869015411	Mg binding site [ion binding]; other site
76869015412	active-site loop [active]
76869015413	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
76869015414	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
76869015415	hypothetical protein; Provisional; Region: PRK01254
76869015416	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
76869015417	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
76869015418	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
76869015419	replicative DNA helicase; Provisional; Region: PRK05748
76869015420	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
76869015421	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
76869015422	Walker A motif; other site
76869015423	ATP binding site [chemical binding]; other site
76869015424	Walker B motif; other site
76869015425	DNA binding loops [nucleotide binding]
76869015426	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
76869015427	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
76869015428	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
76869015429	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
76869015430	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
76869015431	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
76869015432	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
76869015433	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
76869015434	ribonuclease R; Region: RNase_R; TIGR02063
76869015435	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
76869015436	RNB domain; Region: RNB; pfam00773
76869015437	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
76869015438	RNA binding site [nucleotide binding]; other site
76869015439	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
76869015440	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869015441	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
76869015442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869015443	dimer interface [polypeptide binding]; other site
76869015444	conserved gate region; other site
76869015445	putative PBP binding loops; other site
76869015446	ABC-ATPase subunit interface; other site
76869015447	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
76869015448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869015449	dimer interface [polypeptide binding]; other site
76869015450	conserved gate region; other site
76869015451	putative PBP binding loops; other site
76869015452	ABC-ATPase subunit interface; other site
76869015453	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
76869015454	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869015455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869015456	dimer interface [polypeptide binding]; other site
76869015457	putative CheW interface [polypeptide binding]; other site
76869015458	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
76869015459	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
76869015460	GDP-binding site [chemical binding]; other site
76869015461	ACT binding site; other site
76869015462	IMP binding site; other site
76869015463	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
76869015464	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
76869015465	dimer interface [polypeptide binding]; other site
76869015466	motif 1; other site
76869015467	active site
76869015468	motif 2; other site
76869015469	motif 3; other site
76869015470	FtsH protease regulator HflC; Provisional; Region: PRK11029
76869015471	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
76869015472	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
76869015473	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
76869015474	HflK protein; Region: hflK; TIGR01933
76869015475	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
76869015476	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
76869015477	HflX GTPase family; Region: HflX; cd01878
76869015478	G1 box; other site
76869015479	GTP/Mg2+ binding site [chemical binding]; other site
76869015480	Switch I region; other site
76869015481	G2 box; other site
76869015482	G3 box; other site
76869015483	Switch II region; other site
76869015484	G4 box; other site
76869015485	G5 box; other site
76869015486	bacterial Hfq-like; Region: Hfq; cd01716
76869015487	hexamer interface [polypeptide binding]; other site
76869015488	Sm1 motif; other site
76869015489	RNA binding site [nucleotide binding]; other site
76869015490	Sm2 motif; other site
76869015491	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
76869015492	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
76869015493	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
76869015494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869015495	ATP binding site [chemical binding]; other site
76869015496	Mg2+ binding site [ion binding]; other site
76869015497	G-X-G motif; other site
76869015498	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
76869015499	ATP binding site [chemical binding]; other site
76869015500	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
76869015501	AMIN domain; Region: AMIN; pfam11741
76869015502	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
76869015503	active site
76869015504	metal binding site [ion binding]; metal-binding site
76869015505	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
76869015506	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
76869015507	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
76869015508	putative ATP binding site [chemical binding]; other site
76869015509	putative substrate binding site [chemical binding]; other site
76869015510	epoxyqueuosine reductase; Region: TIGR00276
76869015511	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
76869015512	Predicted membrane protein [Function unknown]; Region: COG2860
76869015513	UPF0126 domain; Region: UPF0126; pfam03458
76869015514	UPF0126 domain; Region: UPF0126; pfam03458
76869015515	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
76869015516	catalytic site [active]
76869015517	putative active site [active]
76869015518	putative substrate binding site [chemical binding]; other site
76869015519	dimer interface [polypeptide binding]; other site
76869015520	GTPase RsgA; Reviewed; Region: PRK12288
76869015521	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
76869015522	RNA binding site [nucleotide binding]; other site
76869015523	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
76869015524	GTPase/Zn-binding domain interface [polypeptide binding]; other site
76869015525	GTP/Mg2+ binding site [chemical binding]; other site
76869015526	G4 box; other site
76869015527	G5 box; other site
76869015528	G1 box; other site
76869015529	Switch I region; other site
76869015530	G2 box; other site
76869015531	G3 box; other site
76869015532	Switch II region; other site
76869015533	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
76869015534	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
76869015535	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
76869015536	ligand binding site [chemical binding]; other site
76869015537	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
76869015538	flagellar motor protein MotA; Validated; Region: PRK09110
76869015539	HDOD domain; Region: HDOD; pfam08668
76869015540	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
76869015541	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
76869015542	active site residue [active]
76869015543	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
76869015544	active site residue [active]
76869015545	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
76869015546	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
76869015547	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
76869015548	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
76869015549	phosphoserine phosphatase SerB; Region: serB; TIGR00338
76869015550	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869015551	motif II; other site
76869015552	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
76869015553	Protein of unknown function (DUF330); Region: DUF330; pfam03886
76869015554	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
76869015555	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
76869015556	CAP-like domain; other site
76869015557	active site
76869015558	primary dimer interface [polypeptide binding]; other site
76869015559	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
76869015560	catalytic motif [active]
76869015561	Catalytic residue [active]
76869015562	SdiA-regulated; Region: SdiA-regulated; cd09971
76869015563	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
76869015564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869015565	ATP binding site [chemical binding]; other site
76869015566	Mg2+ binding site [ion binding]; other site
76869015567	G-X-G motif; other site
76869015568	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
76869015569	anchoring element; other site
76869015570	dimer interface [polypeptide binding]; other site
76869015571	ATP binding site [chemical binding]; other site
76869015572	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
76869015573	active site
76869015574	metal binding site [ion binding]; metal-binding site
76869015575	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
76869015576	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
76869015577	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
76869015578	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
76869015579	active site
76869015580	metal binding site [ion binding]; metal-binding site
76869015581	hexamer interface [polypeptide binding]; other site
76869015582	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
76869015583	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
76869015584	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
76869015585	dimer interface [polypeptide binding]; other site
76869015586	ADP-ribose binding site [chemical binding]; other site
76869015587	active site
76869015588	nudix motif; other site
76869015589	metal binding site [ion binding]; metal-binding site
76869015590	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
76869015591	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
76869015592	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
76869015593	Na binding site [ion binding]; other site
76869015594	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
76869015595	ThiC-associated domain; Region: ThiC-associated; pfam13667
76869015596	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
76869015597	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
76869015598	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
76869015599	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
76869015600	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
76869015601	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869015602	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869015603	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869015604	dimerization interface [polypeptide binding]; other site
76869015605	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
76869015606	FAD dependent oxidoreductase; Region: DAO; pfam01266
76869015607	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869015608	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
76869015609	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
76869015610	active site
76869015611	catalytic tetrad [active]
76869015612	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
76869015613	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
76869015614	putative ribose interaction site [chemical binding]; other site
76869015615	putative ADP binding site [chemical binding]; other site
76869015616	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
76869015617	active site
76869015618	nucleotide binding site [chemical binding]; other site
76869015619	HIGH motif; other site
76869015620	KMSKS motif; other site
76869015621	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
76869015622	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
76869015623	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
76869015624	Walker A/P-loop; other site
76869015625	ATP binding site [chemical binding]; other site
76869015626	Q-loop/lid; other site
76869015627	ABC transporter signature motif; other site
76869015628	Walker B; other site
76869015629	D-loop; other site
76869015630	H-loop/switch region; other site
76869015631	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
76869015632	O-Antigen ligase; Region: Wzy_C; pfam04932
76869015633	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
76869015634	active site
76869015635	substrate binding site [chemical binding]; other site
76869015636	ATP binding site [chemical binding]; other site
76869015637	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869015638	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
76869015639	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
76869015640	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
76869015641	Mig-14; Region: Mig-14; pfam07395
76869015642	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
76869015643	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
76869015644	putative ADP-binding pocket [chemical binding]; other site
76869015645	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
76869015646	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
76869015647	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
76869015648	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
76869015649	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
76869015650	Na binding site [ion binding]; other site
76869015651	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
76869015652	Predicted transcriptional regulator [Transcription]; Region: COG3905
76869015653	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
76869015654	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
76869015655	Glutamate binding site [chemical binding]; other site
76869015656	NAD binding site [chemical binding]; other site
76869015657	catalytic residues [active]
76869015658	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
76869015659	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
76869015660	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
76869015661	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
76869015662	active site
76869015663	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
76869015664	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
76869015665	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
76869015666	putative transporter; Provisional; Region: PRK10504
76869015667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869015668	putative substrate translocation pore; other site
76869015669	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
76869015670	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
76869015671	ATP binding site [chemical binding]; other site
76869015672	Mg++ binding site [ion binding]; other site
76869015673	motif III; other site
76869015674	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869015675	nucleotide binding region [chemical binding]; other site
76869015676	ATP-binding site [chemical binding]; other site
76869015677	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
76869015678	putative RNA binding site [nucleotide binding]; other site
76869015679	HI0933-like protein; Region: HI0933_like; pfam03486
76869015680	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869015681	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
76869015682	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
76869015683	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
76869015684	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869015685	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869015686	substrate binding pocket [chemical binding]; other site
76869015687	membrane-bound complex binding site; other site
76869015688	hinge residues; other site
76869015689	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869015690	Coenzyme A binding pocket [chemical binding]; other site
76869015691	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
76869015692	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
76869015693	Response regulator receiver domain; Region: Response_reg; pfam00072
76869015694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015695	active site
76869015696	phosphorylation site [posttranslational modification]
76869015697	intermolecular recognition site; other site
76869015698	dimerization interface [polypeptide binding]; other site
76869015699	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869015700	PAS domain; Region: PAS_9; pfam13426
76869015701	putative active site [active]
76869015702	heme pocket [chemical binding]; other site
76869015703	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869015704	metal binding site [ion binding]; metal-binding site
76869015705	active site
76869015706	I-site; other site
76869015707	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869015708	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
76869015709	intersubunit interface [polypeptide binding]; other site
76869015710	active site
76869015711	zinc binding site [ion binding]; other site
76869015712	Na+ binding site [ion binding]; other site
76869015713	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
76869015714	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
76869015715	Phosphoglycerate kinase; Region: PGK; pfam00162
76869015716	substrate binding site [chemical binding]; other site
76869015717	hinge regions; other site
76869015718	ADP binding site [chemical binding]; other site
76869015719	catalytic site [active]
76869015720	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
76869015721	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
76869015722	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
76869015723	transketolase; Reviewed; Region: PRK12753
76869015724	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
76869015725	TPP-binding site [chemical binding]; other site
76869015726	dimer interface [polypeptide binding]; other site
76869015727	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
76869015728	PYR/PP interface [polypeptide binding]; other site
76869015729	dimer interface [polypeptide binding]; other site
76869015730	TPP binding site [chemical binding]; other site
76869015731	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
76869015732	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869015733	putative DNA binding site [nucleotide binding]; other site
76869015734	putative Zn2+ binding site [ion binding]; other site
76869015735	Methyltransferase domain; Region: Methyltransf_23; pfam13489
76869015736	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869015737	S-adenosylmethionine binding site [chemical binding]; other site
76869015738	S-adenosylmethionine synthetase; Validated; Region: PRK05250
76869015739	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
76869015740	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
76869015741	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
76869015742	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
76869015743	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
76869015744	nucleotide binding pocket [chemical binding]; other site
76869015745	K-X-D-G motif; other site
76869015746	catalytic site [active]
76869015747	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
76869015748	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
76869015749	Cytochrome C' Region: Cytochrom_C_2; pfam01322
76869015750	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
76869015751	MltA specific insert domain; Region: MltA; pfam03562
76869015752	3D domain; Region: 3D; pfam06725
76869015753	MAPEG family; Region: MAPEG; cl09190
76869015754	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
76869015755	EamA-like transporter family; Region: EamA; pfam00892
76869015756	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
76869015757	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
76869015758	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
76869015759	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
76869015760	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
76869015761	homotetramer interface [polypeptide binding]; other site
76869015762	ligand binding site [chemical binding]; other site
76869015763	catalytic site [active]
76869015764	NAD binding site [chemical binding]; other site
76869015765	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
76869015766	FAD binding site [chemical binding]; other site
76869015767	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869015768	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869015769	substrate binding pocket [chemical binding]; other site
76869015770	membrane-bound complex binding site; other site
76869015771	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
76869015772	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
76869015773	ATP binding site [chemical binding]; other site
76869015774	Mg++ binding site [ion binding]; other site
76869015775	motif III; other site
76869015776	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869015777	nucleotide binding region [chemical binding]; other site
76869015778	ATP-binding site [chemical binding]; other site
76869015779	hypothetical protein; Provisional; Region: PRK03757
76869015780	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
76869015781	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
76869015782	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
76869015783	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869015784	inhibitor-cofactor binding pocket; inhibition site
76869015785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869015786	catalytic residue [active]
76869015787	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
76869015788	RNA methyltransferase, RsmE family; Region: TIGR00046
76869015789	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
76869015790	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
76869015791	CheW-like domain; Region: CheW; pfam01584
76869015792	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869015793	putative binding surface; other site
76869015794	active site
76869015795	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869015796	putative binding surface; other site
76869015797	active site
76869015798	Hpt domain; Region: Hpt; pfam01627
76869015799	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
76869015800	putative binding surface; other site
76869015801	active site
76869015802	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
76869015803	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
76869015804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869015805	ATP binding site [chemical binding]; other site
76869015806	Mg2+ binding site [ion binding]; other site
76869015807	G-X-G motif; other site
76869015808	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
76869015809	Response regulator receiver domain; Region: Response_reg; pfam00072
76869015810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015811	active site
76869015812	phosphorylation site [posttranslational modification]
76869015813	intermolecular recognition site; other site
76869015814	dimerization interface [polypeptide binding]; other site
76869015815	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
76869015816	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869015817	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869015818	dimer interface [polypeptide binding]; other site
76869015819	putative CheW interface [polypeptide binding]; other site
76869015820	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
76869015821	Response regulator receiver domain; Region: Response_reg; pfam00072
76869015822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015823	active site
76869015824	phosphorylation site [posttranslational modification]
76869015825	intermolecular recognition site; other site
76869015826	dimerization interface [polypeptide binding]; other site
76869015827	Response regulator receiver domain; Region: Response_reg; pfam00072
76869015828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015829	active site
76869015830	phosphorylation site [posttranslational modification]
76869015831	intermolecular recognition site; other site
76869015832	dimerization interface [polypeptide binding]; other site
76869015833	glutathione synthetase; Provisional; Region: PRK05246
76869015834	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
76869015835	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
76869015836	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
76869015837	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
76869015838	hypothetical protein; Validated; Region: PRK00228
76869015839	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
76869015840	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
76869015841	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869015842	active site
76869015843	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
76869015844	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
76869015845	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
76869015846	dihydroorotase; Validated; Region: pyrC; PRK09357
76869015847	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
76869015848	active site
76869015849	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
76869015850	active site
76869015851	HslU subunit interaction site [polypeptide binding]; other site
76869015852	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
76869015853	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869015854	Walker A motif; other site
76869015855	ATP binding site [chemical binding]; other site
76869015856	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
76869015857	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
76869015858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
76869015859	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
76869015860	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
76869015861	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
76869015862	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
76869015863	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
76869015864	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
76869015865	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869015866	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869015867	Bacterial transcriptional repressor; Region: TetR; pfam13972
76869015868	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
76869015869	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
76869015870	putative polyhydroxyalkanoic acid system protein; Region: PHA_gran_rgn; TIGR02610
76869015871	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
76869015872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869015873	S-adenosylmethionine binding site [chemical binding]; other site
76869015874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
76869015875	SCP-2 sterol transfer family; Region: SCP2; pfam02036
76869015876	ABC1 family; Region: ABC1; cl17513
76869015877	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
76869015878	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
76869015879	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
76869015880	metal binding site [ion binding]; metal-binding site
76869015881	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
76869015882	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
76869015883	sec-independent translocase; Provisional; Region: tatB; PRK00404
76869015884	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
76869015885	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
76869015886	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
76869015887	RNA methyltransferase, RsmE family; Region: TIGR00046
76869015888	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869015889	dimerization interface [polypeptide binding]; other site
76869015890	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869015891	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869015892	dimer interface [polypeptide binding]; other site
76869015893	putative CheW interface [polypeptide binding]; other site
76869015894	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
76869015895	dimerization interface [polypeptide binding]; other site
76869015896	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
76869015897	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
76869015898	dimer interface [polypeptide binding]; other site
76869015899	putative CheW interface [polypeptide binding]; other site
76869015900	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869015901	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869015902	Walker A/P-loop; other site
76869015903	ATP binding site [chemical binding]; other site
76869015904	Q-loop/lid; other site
76869015905	ABC transporter signature motif; other site
76869015906	Walker B; other site
76869015907	D-loop; other site
76869015908	H-loop/switch region; other site
76869015909	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
76869015910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869015911	dimer interface [polypeptide binding]; other site
76869015912	conserved gate region; other site
76869015913	putative PBP binding loops; other site
76869015914	ABC-ATPase subunit interface; other site
76869015915	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
76869015916	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869015917	substrate binding pocket [chemical binding]; other site
76869015918	membrane-bound complex binding site; other site
76869015919	hinge residues; other site
76869015920	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
76869015921	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
76869015922	Ligand binding site; other site
76869015923	DXD motif; other site
76869015924	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
76869015925	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
76869015926	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
76869015927	putative active site [active]
76869015928	dimerization interface [polypeptide binding]; other site
76869015929	putative tRNAtyr binding site [nucleotide binding]; other site
76869015930	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
76869015931	TAP-like protein; Region: Abhydrolase_4; pfam08386
76869015932	N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017
76869015933	imidazolonepropionase; Validated; Region: PRK09356
76869015934	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
76869015935	active site
76869015936	putative proline-specific permease; Provisional; Region: proY; PRK10580
76869015937	Spore germination protein; Region: Spore_permease; cl17796
76869015938	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
76869015939	active sites [active]
76869015940	tetramer interface [polypeptide binding]; other site
76869015941	urocanate hydratase; Provisional; Region: PRK05414
76869015942	HutD; Region: HutD; pfam05962
76869015943	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
76869015944	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869015945	DNA-binding site [nucleotide binding]; DNA binding site
76869015946	UTRA domain; Region: UTRA; pfam07702
76869015947	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
76869015948	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
76869015949	active site
76869015950	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
76869015951	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
76869015952	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
76869015953	fructose-1,6-bisphosphatase family protein; Region: PLN02628
76869015954	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
76869015955	AMP binding site [chemical binding]; other site
76869015956	metal binding site [ion binding]; metal-binding site
76869015957	active site
76869015958	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
76869015959	homodimer interface [polypeptide binding]; other site
76869015960	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
76869015961	active site pocket [active]
76869015962	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
76869015963	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
76869015964	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
76869015965	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
76869015966	G1 box; other site
76869015967	putative GEF interaction site [polypeptide binding]; other site
76869015968	GTP/Mg2+ binding site [chemical binding]; other site
76869015969	Switch I region; other site
76869015970	G2 box; other site
76869015971	G3 box; other site
76869015972	Switch II region; other site
76869015973	G4 box; other site
76869015974	G5 box; other site
76869015975	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
76869015976	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
76869015977	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
76869015978	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
76869015979	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
76869015980	Ligand Binding Site [chemical binding]; other site
76869015981	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
76869015982	glutamine synthetase; Provisional; Region: glnA; PRK09469
76869015983	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
76869015984	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869015985	chorismate mutase; Provisional; Region: PRK09269
76869015986	Chorismate mutase type II; Region: CM_2; cl00693
76869015987	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
76869015988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869015989	dimer interface [polypeptide binding]; other site
76869015990	phosphorylation site [posttranslational modification]
76869015991	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869015992	ATP binding site [chemical binding]; other site
76869015993	Mg2+ binding site [ion binding]; other site
76869015994	G-X-G motif; other site
76869015995	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
76869015996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869015997	active site
76869015998	phosphorylation site [posttranslational modification]
76869015999	intermolecular recognition site; other site
76869016000	dimerization interface [polypeptide binding]; other site
76869016001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869016002	Walker A motif; other site
76869016003	ATP binding site [chemical binding]; other site
76869016004	Walker B motif; other site
76869016005	arginine finger; other site
76869016006	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
76869016007	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
76869016008	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
76869016009	SecA binding site; other site
76869016010	Preprotein binding site; other site
76869016011	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
76869016012	GSH binding site [chemical binding]; other site
76869016013	catalytic residues [active]
76869016014	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
76869016015	active site residue [active]
76869016016	phosphoglyceromutase; Provisional; Region: PRK05434
76869016017	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
76869016018	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
76869016019	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
76869016020	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869016021	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
76869016022	C-terminal peptidase (prc); Region: prc; TIGR00225
76869016023	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
76869016024	protein binding site [polypeptide binding]; other site
76869016025	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
76869016026	Catalytic dyad [active]
76869016027	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
76869016028	NodB motif; other site
76869016029	putative active site [active]
76869016030	putative catalytic site [active]
76869016031	Zn binding site [ion binding]; other site
76869016032	BCCT family transporter; Region: BCCT; cl00569
76869016033	transcriptional regulator BetI; Validated; Region: PRK00767
76869016034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869016035	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
76869016036	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
76869016037	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
76869016038	tetrameric interface [polypeptide binding]; other site
76869016039	NAD binding site [chemical binding]; other site
76869016040	catalytic residues [active]
76869016041	choline dehydrogenase; Validated; Region: PRK02106
76869016042	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
76869016043	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869016044	potassium/proton antiporter; Reviewed; Region: PRK05326
76869016045	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
76869016046	TrkA-C domain; Region: TrkA_C; pfam02080
76869016047	Transporter associated domain; Region: CorC_HlyC; smart01091
76869016048	hypothetical protein; Provisional; Region: PRK11281
76869016049	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
76869016050	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869016051	Uncharacterized conserved protein [Function unknown]; Region: COG0397
76869016052	hypothetical protein; Validated; Region: PRK00029
76869016053	thioredoxin 2; Provisional; Region: PRK10996
76869016054	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
76869016055	catalytic residues [active]
76869016056	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
76869016057	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869016058	P-loop; other site
76869016059	Magnesium ion binding site [ion binding]; other site
76869016060	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869016061	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869016062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016063	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
76869016064	dimerization interface [polypeptide binding]; other site
76869016065	substrate binding pocket [chemical binding]; other site
76869016066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869016067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869016068	putative substrate translocation pore; other site
76869016069	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
76869016070	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
76869016071	substrate binding site [chemical binding]; other site
76869016072	active site
76869016073	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
76869016074	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
76869016075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
76869016076	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
76869016077	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
76869016078	active site
76869016079	dimer interface [polypeptide binding]; other site
76869016080	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
76869016081	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
76869016082	active site
76869016083	FMN binding site [chemical binding]; other site
76869016084	substrate binding site [chemical binding]; other site
76869016085	3Fe-4S cluster binding site [ion binding]; other site
76869016086	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
76869016087	domain interface; other site
76869016088	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
76869016089	Sporulation related domain; Region: SPOR; pfam05036
76869016090	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
76869016091	active site
76869016092	dimer interface [polypeptide binding]; other site
76869016093	metal binding site [ion binding]; metal-binding site
76869016094	shikimate kinase; Reviewed; Region: aroK; PRK00131
76869016095	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
76869016096	ADP binding site [chemical binding]; other site
76869016097	magnesium binding site [ion binding]; other site
76869016098	putative shikimate binding site; other site
76869016099	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
76869016100	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
76869016101	Secretin and TonB N terminus short domain; Region: STN; smart00965
76869016102	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
76869016103	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
76869016104	Pilus assembly protein, PilO; Region: PilO; cl01234
76869016105	Pilus assembly protein, PilP; Region: PilP; pfam04351
76869016106	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
76869016107	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
76869016108	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
76869016109	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
76869016110	Transglycosylase; Region: Transgly; pfam00912
76869016111	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
76869016112	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
76869016113	Malic enzyme, N-terminal domain; Region: malic; pfam00390
76869016114	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
76869016115	putative NAD(P) binding site [chemical binding]; other site
76869016116	Staphylococcal nuclease homologues; Region: SNc; smart00318
76869016117	Catalytic site; other site
76869016118	Staphylococcal nuclease homologue; Region: SNase; pfam00565
76869016119	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
76869016120	primosome assembly protein PriA; Validated; Region: PRK05580
76869016121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869016122	ATP binding site [chemical binding]; other site
76869016123	putative Mg++ binding site [ion binding]; other site
76869016124	helicase superfamily c-terminal domain; Region: HELICc; smart00490
76869016125	ATP-binding site [chemical binding]; other site
76869016126	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
76869016127	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
76869016128	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
76869016129	active site
76869016130	HIGH motif; other site
76869016131	KMSK motif region; other site
76869016132	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
76869016133	tRNA binding surface [nucleotide binding]; other site
76869016134	anticodon binding site; other site
76869016135	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
76869016136	Sporulation related domain; Region: SPOR; pfam05036
76869016137	TM2 domain; Region: TM2; cl00984
76869016138	TM2 domain; Region: TM2; cl00984
76869016139	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
76869016140	NlpC/P60 family; Region: NLPC_P60; pfam00877
76869016141	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
76869016142	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
76869016143	Walker A motif; other site
76869016144	ATP binding site [chemical binding]; other site
76869016145	Walker B motif; other site
76869016146	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
76869016147	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869016148	catalytic residue [active]
76869016149	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
76869016150	pyrroline-5-carboxylate reductase; Region: PLN02688
76869016151	YGGT family; Region: YGGT; pfam02325
76869016152	YGGT family; Region: YGGT; pfam02325
76869016153	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
76869016154	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
76869016155	hypothetical protein; Provisional; Region: PRK08317
76869016156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869016157	S-adenosylmethionine binding site [chemical binding]; other site
76869016158	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
76869016159	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
76869016160	active site
76869016161	dimerization interface [polypeptide binding]; other site
76869016162	HemN family oxidoreductase; Provisional; Region: PRK05660
76869016163	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
76869016164	FeS/SAM binding site; other site
76869016165	HemN C-terminal domain; Region: HemN_C; pfam06969
76869016166	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
76869016167	Methyltransferase domain; Region: Methyltransf_31; pfam13847
76869016168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869016169	S-adenosylmethionine binding site [chemical binding]; other site
76869016170	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
76869016171	ThiS interaction site; other site
76869016172	putative active site [active]
76869016173	tetramer interface [polypeptide binding]; other site
76869016174	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
76869016175	thiS-thiF/thiG interaction site; other site
76869016176	Protein of unknown function (DUF423); Region: DUF423; pfam04241
76869016177	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
76869016178	Transglycosylase; Region: Transgly; cl17702
76869016179	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
76869016180	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
76869016181	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
76869016182	DNA binding residues [nucleotide binding]
76869016183	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
76869016184	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
76869016185	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
76869016186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869016187	Walker A/P-loop; other site
76869016188	ATP binding site [chemical binding]; other site
76869016189	Q-loop/lid; other site
76869016190	ABC transporter signature motif; other site
76869016191	Walker B; other site
76869016192	D-loop; other site
76869016193	H-loop/switch region; other site
76869016194	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
76869016195	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
76869016196	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
76869016197	P loop; other site
76869016198	GTP binding site [chemical binding]; other site
76869016199	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
76869016200	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
76869016201	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869016202	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
76869016203	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869016204	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
76869016205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869016206	S-adenosylmethionine binding site [chemical binding]; other site
76869016207	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
76869016208	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
76869016209	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869016210	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
76869016211	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
76869016212	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
76869016213	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
76869016214	nucleophilic elbow; other site
76869016215	catalytic triad; other site
76869016216	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
76869016217	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
76869016218	active site residue [active]
76869016219	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
76869016220	active site residue [active]
76869016221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
76869016222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
76869016223	Bacterial transcriptional repressor; Region: TetR; pfam13972
76869016224	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
76869016225	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
76869016226	NAD(P) binding site [chemical binding]; other site
76869016227	catalytic residues [active]
76869016228	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
76869016229	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
76869016230	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
76869016231	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
76869016232	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
76869016233	active site
76869016234	(T/H)XGH motif; other site
76869016235	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
76869016236	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
76869016237	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
76869016238	DNA binding site [nucleotide binding]
76869016239	catalytic residue [active]
76869016240	H2TH interface [polypeptide binding]; other site
76869016241	putative catalytic residues [active]
76869016242	turnover-facilitating residue; other site
76869016243	intercalation triad [nucleotide binding]; other site
76869016244	8OG recognition residue [nucleotide binding]; other site
76869016245	putative reading head residues; other site
76869016246	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
76869016247	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
76869016248	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
76869016249	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
76869016250	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
76869016251	putative RNA binding site [nucleotide binding]; other site
76869016252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869016253	S-adenosylmethionine binding site [chemical binding]; other site
76869016254	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
76869016255	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
76869016256	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
76869016257	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
76869016258	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
76869016259	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
76869016260	folate binding site [chemical binding]; other site
76869016261	NADP+ binding site [chemical binding]; other site
76869016262	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
76869016263	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
76869016264	G1 box; other site
76869016265	GTP/Mg2+ binding site [chemical binding]; other site
76869016266	G2 box; other site
76869016267	Switch I region; other site
76869016268	G3 box; other site
76869016269	Switch II region; other site
76869016270	G4 box; other site
76869016271	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
76869016272	G5 box; other site
76869016273	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
76869016274	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
76869016275	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
76869016276	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
76869016277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016278	dimer interface [polypeptide binding]; other site
76869016279	conserved gate region; other site
76869016280	putative PBP binding loops; other site
76869016281	ABC-ATPase subunit interface; other site
76869016282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016283	dimer interface [polypeptide binding]; other site
76869016284	conserved gate region; other site
76869016285	putative PBP binding loops; other site
76869016286	ABC-ATPase subunit interface; other site
76869016287	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
76869016288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869016289	Walker A/P-loop; other site
76869016290	ATP binding site [chemical binding]; other site
76869016291	Q-loop/lid; other site
76869016292	ABC transporter signature motif; other site
76869016293	Walker B; other site
76869016294	D-loop; other site
76869016295	H-loop/switch region; other site
76869016296	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
76869016297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016298	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869016299	dimerization interface [polypeptide binding]; other site
76869016300	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
76869016301	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
76869016302	Soluble P-type ATPase [General function prediction only]; Region: COG4087
76869016303	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
76869016304	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
76869016305	DNA binding residues [nucleotide binding]
76869016306	dimer interface [polypeptide binding]; other site
76869016307	putative metal binding site [ion binding]; other site
76869016308	thymidylate synthase; Provisional; Region: thyA; PRK13821
76869016309	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
76869016310	dimerization interface [polypeptide binding]; other site
76869016311	active site
76869016312	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
76869016313	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
76869016314	NRDE protein; Region: NRDE; cl01315
76869016315	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
76869016316	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
76869016317	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
76869016318	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
76869016319	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
76869016320	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
76869016321	putative active site [active]
76869016322	Ap4A binding site [chemical binding]; other site
76869016323	nudix motif; other site
76869016324	putative metal binding site [ion binding]; other site
76869016325	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
76869016326	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869016327	motif II; other site
76869016328	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
76869016329	threonine dehydratase; Reviewed; Region: PRK09224
76869016330	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
76869016331	tetramer interface [polypeptide binding]; other site
76869016332	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869016333	catalytic residue [active]
76869016334	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
76869016335	putative Ile/Val binding site [chemical binding]; other site
76869016336	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
76869016337	putative Ile/Val binding site [chemical binding]; other site
76869016338	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
76869016339	tetramer (dimer of dimers) interface [polypeptide binding]; other site
76869016340	active site
76869016341	dimer interface [polypeptide binding]; other site
76869016342	SdiA-regulated; Region: SdiA-regulated; pfam06977
76869016343	SdiA-regulated; Region: SdiA-regulated; cd09971
76869016344	putative active site [active]
76869016345	SdiA-regulated; Region: SdiA-regulated; pfam06977
76869016346	SdiA-regulated; Region: SdiA-regulated; cd09971
76869016347	putative active site [active]
76869016348	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
76869016349	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
76869016350	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
76869016351	FAD binding domain; Region: FAD_binding_4; pfam01565
76869016352	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
76869016353	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
76869016354	ligand binding site [chemical binding]; other site
76869016355	NAD binding site [chemical binding]; other site
76869016356	tetramer interface [polypeptide binding]; other site
76869016357	catalytic site [active]
76869016358	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
76869016359	L-serine binding site [chemical binding]; other site
76869016360	ACT domain interface; other site
76869016361	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
76869016362	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869016363	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
76869016364	membrane-bound complex binding site; other site
76869016365	hinge residues; other site
76869016366	Uncharacterized conserved protein [Function unknown]; Region: COG1683
76869016367	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
76869016368	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
76869016369	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
76869016370	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
76869016371	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
76869016372	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
76869016373	maltose O-acetyltransferase; Provisional; Region: PRK10092
76869016374	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
76869016375	active site
76869016376	substrate binding site [chemical binding]; other site
76869016377	trimer interface [polypeptide binding]; other site
76869016378	CoA binding site [chemical binding]; other site
76869016379	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
76869016380	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
76869016381	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
76869016382	active site
76869016383	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
76869016384	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
76869016385	substrate binding pocket [chemical binding]; other site
76869016386	membrane-bound complex binding site; other site
76869016387	hinge residues; other site
76869016388	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
76869016389	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
76869016390	Walker A/P-loop; other site
76869016391	ATP binding site [chemical binding]; other site
76869016392	Q-loop/lid; other site
76869016393	ABC transporter signature motif; other site
76869016394	Walker B; other site
76869016395	D-loop; other site
76869016396	H-loop/switch region; other site
76869016397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016398	dimer interface [polypeptide binding]; other site
76869016399	conserved gate region; other site
76869016400	putative PBP binding loops; other site
76869016401	ABC-ATPase subunit interface; other site
76869016402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016403	dimer interface [polypeptide binding]; other site
76869016404	conserved gate region; other site
76869016405	putative PBP binding loops; other site
76869016406	ABC-ATPase subunit interface; other site
76869016407	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
76869016408	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
76869016409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
76869016410	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
76869016411	Walker A motif; other site
76869016412	ATP binding site [chemical binding]; other site
76869016413	Walker B motif; other site
76869016414	arginine finger; other site
76869016415	Serine hydrolase; Region: Ser_hydrolase; pfam06821
76869016416	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
76869016417	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
76869016418	TolR protein; Region: tolR; TIGR02801
76869016419	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
76869016420	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
76869016421	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
76869016422	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
76869016423	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
76869016424	Walker A/P-loop; other site
76869016425	ATP binding site [chemical binding]; other site
76869016426	Q-loop/lid; other site
76869016427	ABC transporter signature motif; other site
76869016428	Walker B; other site
76869016429	D-loop; other site
76869016430	H-loop/switch region; other site
76869016431	TOBE-like domain; Region: TOBE_3; pfam12857
76869016432	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
76869016433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016434	dimer interface [polypeptide binding]; other site
76869016435	conserved gate region; other site
76869016436	putative PBP binding loops; other site
76869016437	ABC-ATPase subunit interface; other site
76869016438	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
76869016439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016440	dimer interface [polypeptide binding]; other site
76869016441	conserved gate region; other site
76869016442	putative PBP binding loops; other site
76869016443	ABC-ATPase subunit interface; other site
76869016444	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
76869016445	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
76869016446	Uncharacterized small protein [Function unknown]; Region: COG5583
76869016447	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
76869016448	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869016449	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869016450	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869016451	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869016452	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
76869016453	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869016454	Transposase IS200 like; Region: Y1_Tnp; pfam01797
76869016455	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869016456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016457	dimer interface [polypeptide binding]; other site
76869016458	conserved gate region; other site
76869016459	putative PBP binding loops; other site
76869016460	ABC-ATPase subunit interface; other site
76869016461	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
76869016462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016463	dimer interface [polypeptide binding]; other site
76869016464	conserved gate region; other site
76869016465	putative PBP binding loops; other site
76869016466	ABC-ATPase subunit interface; other site
76869016467	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
76869016468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869016469	Walker A/P-loop; other site
76869016470	ATP binding site [chemical binding]; other site
76869016471	Q-loop/lid; other site
76869016472	ABC transporter signature motif; other site
76869016473	Walker B; other site
76869016474	D-loop; other site
76869016475	H-loop/switch region; other site
76869016476	TOBE domain; Region: TOBE_2; pfam08402
76869016477	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869016478	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869016479	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869016480	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
76869016481	putative aminotransferase; Validated; Region: PRK07480
76869016482	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
76869016483	inhibitor-cofactor binding pocket; inhibition site
76869016484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869016485	catalytic residue [active]
76869016486	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869016487	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869016488	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869016489	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869016490	N-acetylglutamate synthase; Validated; Region: PRK05279
76869016491	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
76869016492	putative feedback inhibition sensing region; other site
76869016493	putative nucleotide binding site [chemical binding]; other site
76869016494	putative substrate binding site [chemical binding]; other site
76869016495	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869016496	Coenzyme A binding pocket [chemical binding]; other site
76869016497	acetylornithine deacetylase; Provisional; Region: PRK05111
76869016498	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
76869016499	metal binding site [ion binding]; metal-binding site
76869016500	putative dimer interface [polypeptide binding]; other site
76869016501	Uncharacterized conserved protein [Function unknown]; Region: COG3025
76869016502	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
76869016503	putative active site [active]
76869016504	putative metal binding residues [ion binding]; other site
76869016505	signature motif; other site
76869016506	putative triphosphate binding site [ion binding]; other site
76869016507	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869016508	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869016509	putative DNA binding site [nucleotide binding]; other site
76869016510	putative Zn2+ binding site [ion binding]; other site
76869016511	AsnC family; Region: AsnC_trans_reg; pfam01037
76869016512	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
76869016513	Type II/IV secretion system protein; Region: T2SE; pfam00437
76869016514	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
76869016515	Walker A motif; other site
76869016516	ATP binding site [chemical binding]; other site
76869016517	Walker B motif; other site
76869016518	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
76869016519	glycine dehydrogenase; Provisional; Region: PRK12566
76869016520	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
76869016521	tetramer interface [polypeptide binding]; other site
76869016522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869016523	catalytic residue [active]
76869016524	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
76869016525	tetramer interface [polypeptide binding]; other site
76869016526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869016527	catalytic residue [active]
76869016528	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
76869016529	lipoyl attachment site [posttranslational modification]; other site
76869016530	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
76869016531	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
76869016532	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
76869016533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016534	dimer interface [polypeptide binding]; other site
76869016535	conserved gate region; other site
76869016536	putative PBP binding loops; other site
76869016537	ABC-ATPase subunit interface; other site
76869016538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016539	dimer interface [polypeptide binding]; other site
76869016540	conserved gate region; other site
76869016541	putative PBP binding loops; other site
76869016542	ABC-ATPase subunit interface; other site
76869016543	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869016544	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
76869016545	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
76869016546	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
76869016547	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
76869016548	active site 2 [active]
76869016549	active site 1 [active]
76869016550	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
76869016551	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
76869016552	proline aminopeptidase P II; Provisional; Region: PRK10879
76869016553	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
76869016554	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
76869016555	active site
76869016556	hypothetical protein; Reviewed; Region: PRK02166
76869016557	TIGR02449 family protein; Region: TIGR02449
76869016558	Cell division protein ZapA; Region: ZapA; pfam05164
76869016559	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
76869016560	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
76869016561	EVE domain; Region: EVE; cl00728
76869016562	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
76869016563	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
76869016564	HlyD family secretion protein; Region: HlyD_3; pfam13437
76869016565	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
76869016566	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
76869016567	Walker A/P-loop; other site
76869016568	ATP binding site [chemical binding]; other site
76869016569	Q-loop/lid; other site
76869016570	ABC transporter signature motif; other site
76869016571	Walker B; other site
76869016572	D-loop; other site
76869016573	H-loop/switch region; other site
76869016574	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
76869016575	Walker A/P-loop; other site
76869016576	ATP binding site [chemical binding]; other site
76869016577	Q-loop/lid; other site
76869016578	ABC transporter signature motif; other site
76869016579	Walker B; other site
76869016580	D-loop; other site
76869016581	H-loop/switch region; other site
76869016582	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
76869016583	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
76869016584	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
76869016585	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
76869016586	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
76869016587	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
76869016588	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
76869016589	NAD(P) binding site [chemical binding]; other site
76869016590	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
76869016591	putative active site pocket [active]
76869016592	dimerization interface [polypeptide binding]; other site
76869016593	putative catalytic residue [active]
76869016594	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
76869016595	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
76869016596	catalytic loop [active]
76869016597	iron binding site [ion binding]; other site
76869016598	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
76869016599	FAD binding pocket [chemical binding]; other site
76869016600	FAD binding motif [chemical binding]; other site
76869016601	phosphate binding motif [ion binding]; other site
76869016602	beta-alpha-beta structure motif; other site
76869016603	NAD binding pocket [chemical binding]; other site
76869016604	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
76869016605	transcription termination factor Rho; Provisional; Region: rho; PRK09376
76869016606	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
76869016607	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
76869016608	RNA binding site [nucleotide binding]; other site
76869016609	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
76869016610	multimer interface [polypeptide binding]; other site
76869016611	Walker A motif; other site
76869016612	ATP binding site [chemical binding]; other site
76869016613	Walker B motif; other site
76869016614	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
76869016615	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
76869016616	catalytic residues [active]
76869016617	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
76869016618	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
76869016619	polyphosphate kinase; Provisional; Region: PRK05443
76869016620	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
76869016621	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
76869016622	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
76869016623	putative active site [active]
76869016624	catalytic site [active]
76869016625	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
76869016626	putative domain interface [polypeptide binding]; other site
76869016627	putative active site [active]
76869016628	catalytic site [active]
76869016629	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
76869016630	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
76869016631	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
76869016632	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
76869016633	conserved cys residue [active]
76869016634	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
76869016635	adenylate cyclase; Provisional; Region: cyaA; PRK09450
76869016636	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
76869016637	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
76869016638	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
76869016639	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
76869016640	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
76869016641	frataxin-like protein; Provisional; Region: cyaY; PRK00446
76869016642	putative iron binding site [ion binding]; other site
76869016643	diaminopimelate decarboxylase; Region: lysA; TIGR01048
76869016644	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
76869016645	active site
76869016646	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869016647	substrate binding site [chemical binding]; other site
76869016648	catalytic residues [active]
76869016649	dimer interface [polypeptide binding]; other site
76869016650	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
76869016651	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
76869016652	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
76869016653	Protein of unknown function, DUF484; Region: DUF484; cl17449
76869016654	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
76869016655	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
76869016656	active site
76869016657	DNA binding site [nucleotide binding]
76869016658	Int/Topo IB signature motif; other site
76869016659	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
76869016660	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
76869016661	motif II; other site
76869016662	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
76869016663	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
76869016664	Nitrogen regulatory protein P-II; Region: P-II; smart00938
76869016665	Membrane fusogenic activity; Region: BMFP; pfam04380
76869016666	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
76869016667	putative active site pocket [active]
76869016668	dimerization interface [polypeptide binding]; other site
76869016669	putative catalytic residue [active]
76869016670	molybdenum-pterin binding domain; Region: Mop; TIGR00638
76869016671	molybdenum-pterin binding domain; Region: Mop; TIGR00638
76869016672	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
76869016673	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
76869016674	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
76869016675	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
76869016676	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
76869016677	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
76869016678	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
76869016679	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
76869016680	TrkA-N domain; Region: TrkA_N; pfam02254
76869016681	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
76869016682	Isochorismatase family; Region: Isochorismatase; pfam00857
76869016683	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
76869016684	catalytic triad [active]
76869016685	dimer interface [polypeptide binding]; other site
76869016686	conserved cis-peptide bond; other site
76869016687	LysR family transcriptional regulator; Provisional; Region: PRK14997
76869016688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016689	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
76869016690	putative effector binding pocket; other site
76869016691	putative dimerization interface [polypeptide binding]; other site
76869016692	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
76869016693	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
76869016694	active site
76869016695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
76869016696	Isochorismatase family; Region: Isochorismatase; pfam00857
76869016697	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
76869016698	catalytic triad [active]
76869016699	dimer interface [polypeptide binding]; other site
76869016700	conserved cis-peptide bond; other site
76869016701	Mechanosensitive ion channel; Region: MS_channel; pfam00924
76869016702	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
76869016703	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
76869016704	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
76869016705	ligand binding site [chemical binding]; other site
76869016706	flexible hinge region; other site
76869016707	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869016708	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869016709	aldehyde dehydrogenase family 7 member; Region: PLN02315
76869016710	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
76869016711	tetrameric interface [polypeptide binding]; other site
76869016712	NAD binding site [chemical binding]; other site
76869016713	catalytic residues [active]
76869016714	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869016715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016716	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
76869016717	dimerization interface [polypeptide binding]; other site
76869016718	substrate binding pocket [chemical binding]; other site
76869016719	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
76869016720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
76869016721	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
76869016722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869016724	dimerization interface [polypeptide binding]; other site
76869016725	multidrug efflux protein NorA; Provisional; Region: PRK00187
76869016726	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
76869016727	cation binding site [ion binding]; other site
76869016728	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
76869016729	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
76869016730	metal binding site [ion binding]; metal-binding site
76869016731	active site
76869016732	I-site; other site
76869016733	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
76869016734	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
76869016735	Part of AAA domain; Region: AAA_19; pfam13245
76869016736	Family description; Region: UvrD_C_2; pfam13538
76869016737	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869016738	active site
76869016739	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
76869016740	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
76869016741	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
76869016742	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
76869016743	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
76869016744	non-specific DNA binding site [nucleotide binding]; other site
76869016745	salt bridge; other site
76869016746	sequence-specific DNA binding site [nucleotide binding]; other site
76869016747	Cupin domain; Region: Cupin_2; pfam07883
76869016748	alanine racemase; Reviewed; Region: dadX; PRK03646
76869016749	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
76869016750	active site
76869016751	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
76869016752	substrate binding site [chemical binding]; other site
76869016753	catalytic residues [active]
76869016754	dimer interface [polypeptide binding]; other site
76869016755	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
76869016756	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
76869016757	hydroxyglutarate oxidase; Provisional; Region: PRK11728
76869016758	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
76869016759	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
76869016760	putative DNA binding site [nucleotide binding]; other site
76869016761	putative Zn2+ binding site [ion binding]; other site
76869016762	AsnC family; Region: AsnC_trans_reg; pfam01037
76869016763	Flagellin N-methylase; Region: FliB; pfam03692
76869016764	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
76869016765	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
76869016766	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
76869016767	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869016768	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869016769	DNA-binding site [nucleotide binding]; DNA binding site
76869016770	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869016771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869016772	homodimer interface [polypeptide binding]; other site
76869016773	catalytic residue [active]
76869016774	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
76869016775	PLD-like domain; Region: PLDc_2; pfam13091
76869016776	putative active site [active]
76869016777	catalytic site [active]
76869016778	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
76869016779	PLD-like domain; Region: PLDc_2; pfam13091
76869016780	putative active site [active]
76869016781	catalytic site [active]
76869016782	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
76869016783	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
76869016784	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
76869016785	NAD(P) binding site [chemical binding]; other site
76869016786	catalytic residues [active]
76869016787	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
76869016788	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
76869016789	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
76869016790	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
76869016791	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
76869016792	peptide binding site [polypeptide binding]; other site
76869016793	hypothetical protein; Reviewed; Region: PRK00024
76869016794	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
76869016795	MPN+ (JAMM) motif; other site
76869016796	Zinc-binding site [ion binding]; other site
76869016797	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
76869016798	Flavoprotein; Region: Flavoprotein; pfam02441
76869016799	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
76869016800	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
76869016801	trimer interface [polypeptide binding]; other site
76869016802	active site
76869016803	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
76869016804	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
76869016805	active site
76869016806	substrate binding site [chemical binding]; other site
76869016807	metal binding site [ion binding]; metal-binding site
76869016808	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
76869016809	feedback inhibition sensing region; other site
76869016810	homohexameric interface [polypeptide binding]; other site
76869016811	nucleotide binding site [chemical binding]; other site
76869016812	N-acetyl-L-glutamate binding site [chemical binding]; other site
76869016813	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
76869016814	active site
76869016815	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
76869016816	putative active site [active]
76869016817	putative catalytic site [active]
76869016818	putative DNA binding site [nucleotide binding]; other site
76869016819	putative phosphate binding site [ion binding]; other site
76869016820	metal binding site A [ion binding]; metal-binding site
76869016821	putative AP binding site [nucleotide binding]; other site
76869016822	putative metal binding site B [ion binding]; other site
76869016823	ribonuclease PH; Reviewed; Region: rph; PRK00173
76869016824	Ribonuclease PH; Region: RNase_PH_bact; cd11362
76869016825	hexamer interface [polypeptide binding]; other site
76869016826	active site
76869016827	hypothetical protein; Provisional; Region: PRK11820
76869016828	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
76869016829	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
76869016830	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
76869016831	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
76869016832	catalytic site [active]
76869016833	G-X2-G-X-G-K; other site
76869016834	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
76869016835	Peptidase C26; Region: Peptidase_C26; pfam07722
76869016836	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
76869016837	catalytic triad [active]
76869016838	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
76869016839	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
76869016840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869016841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016842	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
76869016843	dimerization interface [polypeptide binding]; other site
76869016844	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
76869016845	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
76869016846	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
76869016847	Zn2+ binding site [ion binding]; other site
76869016848	Mg2+ binding site [ion binding]; other site
76869016849	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
76869016850	synthetase active site [active]
76869016851	NTP binding site [chemical binding]; other site
76869016852	metal binding site [ion binding]; metal-binding site
76869016853	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
76869016854	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
76869016855	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
76869016856	homotrimer interaction site [polypeptide binding]; other site
76869016857	putative active site [active]
76869016858	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
76869016859	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
76869016860	putative NAD(P) binding site [chemical binding]; other site
76869016861	tonB-system energizer ExbB; Region: exbB; TIGR02797
76869016862	biopolymer transport protein ExbD; Provisional; Region: PRK11267
76869016863	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
76869016864	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
76869016865	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
76869016866	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
76869016867	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016868	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
76869016869	dimerization interface [polypeptide binding]; other site
76869016870	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
76869016871	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
76869016872	generic binding surface II; other site
76869016873	ssDNA binding site; other site
76869016874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
76869016875	ATP binding site [chemical binding]; other site
76869016876	putative Mg++ binding site [ion binding]; other site
76869016877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
76869016878	nucleotide binding region [chemical binding]; other site
76869016879	ATP-binding site [chemical binding]; other site
76869016880	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
76869016881	putative deacylase active site [active]
76869016882	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
76869016883	SCP-2 sterol transfer family; Region: SCP2; pfam02036
76869016884	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
76869016885	IHF dimer interface [polypeptide binding]; other site
76869016886	IHF - DNA interface [nucleotide binding]; other site
76869016887	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
76869016888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869016889	hypothetical protein; Provisional; Region: PRK07236
76869016890	Rubredoxin [Energy production and conversion]; Region: COG1773
76869016891	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
76869016892	iron binding site [ion binding]; other site
76869016893	Chorismate lyase; Region: Chor_lyase; cl01230
76869016894	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
76869016895	UbiA prenyltransferase family; Region: UbiA; pfam01040
76869016896	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
76869016897	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
76869016898	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
76869016899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869016900	active site
76869016901	phosphorylation site [posttranslational modification]
76869016902	intermolecular recognition site; other site
76869016903	dimerization interface [polypeptide binding]; other site
76869016904	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
76869016905	DNA binding site [nucleotide binding]
76869016906	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
76869016907	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
76869016908	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
76869016909	putative active site [active]
76869016910	heme pocket [chemical binding]; other site
76869016911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
76869016912	dimer interface [polypeptide binding]; other site
76869016913	phosphorylation site [posttranslational modification]
76869016914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
76869016915	ATP binding site [chemical binding]; other site
76869016916	Mg2+ binding site [ion binding]; other site
76869016917	G-X-G motif; other site
76869016918	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
76869016919	Domain of unknown function DUF21; Region: DUF21; pfam01595
76869016920	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
76869016921	Transporter associated domain; Region: CorC_HlyC; smart01091
76869016922	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
76869016923	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
76869016924	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869016925	Response regulator receiver domain; Region: Response_reg; pfam00072
76869016926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
76869016927	active site
76869016928	phosphorylation site [posttranslational modification]
76869016929	intermolecular recognition site; other site
76869016930	dimerization interface [polypeptide binding]; other site
76869016931	transcriptional regulator PhoU; Provisional; Region: PRK11115
76869016932	PhoU domain; Region: PhoU; pfam01895
76869016933	PhoU domain; Region: PhoU; pfam01895
76869016934	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
76869016935	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
76869016936	Walker A/P-loop; other site
76869016937	ATP binding site [chemical binding]; other site
76869016938	Q-loop/lid; other site
76869016939	ABC transporter signature motif; other site
76869016940	Walker B; other site
76869016941	D-loop; other site
76869016942	H-loop/switch region; other site
76869016943	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
76869016944	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
76869016945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016946	dimer interface [polypeptide binding]; other site
76869016947	conserved gate region; other site
76869016948	putative PBP binding loops; other site
76869016949	ABC-ATPase subunit interface; other site
76869016950	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
76869016951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
76869016952	dimer interface [polypeptide binding]; other site
76869016953	conserved gate region; other site
76869016954	putative PBP binding loops; other site
76869016955	ABC-ATPase subunit interface; other site
76869016956	phosphate binding protein; Region: ptsS_2; TIGR02136
76869016957	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
76869016958	S-type Pyocin; Region: Pyocin_S; pfam06958
76869016959	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
76869016960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869016961	metabolite-proton symporter; Region: 2A0106; TIGR00883
76869016962	putative substrate translocation pore; other site
76869016963	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
76869016964	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
76869016965	active site
76869016966	phosphate binding residues; other site
76869016967	catalytic residues [active]
76869016968	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
76869016969	Predicted membrane protein [Function unknown]; Region: COG2261
76869016970	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
76869016971	ATP-grasp domain; Region: ATP-grasp; pfam02222
76869016972	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
76869016973	cell density-dependent motility repressor; Provisional; Region: PRK10082
76869016974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869016975	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
76869016976	dimerization interface [polypeptide binding]; other site
76869016977	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
76869016978	Aspartase; Region: Aspartase; cd01357
76869016979	active sites [active]
76869016980	tetramer interface [polypeptide binding]; other site
76869016981	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
76869016982	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
76869016983	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
76869016984	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
76869016985	active site
76869016986	Zn binding site [ion binding]; other site
76869016987	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
76869016988	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
76869016989	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
76869016990	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
76869016991	DNA-binding site [nucleotide binding]; DNA binding site
76869016992	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
76869016993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
76869016994	homodimer interface [polypeptide binding]; other site
76869016995	catalytic residue [active]
76869016996	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
76869016997	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
76869016998	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
76869016999	Coenzyme A binding pocket [chemical binding]; other site
76869017000	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
76869017001	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
76869017002	pyruvate carboxylase subunit B; Validated; Region: PRK09282
76869017003	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
76869017004	active site
76869017005	catalytic residues [active]
76869017006	metal binding site [ion binding]; metal-binding site
76869017007	homodimer binding site [polypeptide binding]; other site
76869017008	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
76869017009	carboxyltransferase (CT) interaction site; other site
76869017010	biotinylation site [posttranslational modification]; other site
76869017011	pyruvate carboxylase subunit A; Validated; Region: PRK07178
76869017012	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
76869017013	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
76869017014	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
76869017015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
76869017016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
76869017017	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
76869017018	putative dimerization interface [polypeptide binding]; other site
76869017019	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
76869017020	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
76869017021	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
76869017022	putative active site [active]
76869017023	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
76869017024	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
76869017025	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
76869017026	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
76869017027	Part of AAA domain; Region: AAA_19; pfam13245
76869017028	Family description; Region: UvrD_C_2; pfam13538
76869017029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
76869017030	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
76869017031	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
76869017032	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
76869017033	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
76869017034	pyridoxamine kinase; Validated; Region: PRK05756
76869017035	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
76869017036	pyridoxal binding site [chemical binding]; other site
76869017037	dimer interface [polypeptide binding]; other site
76869017038	ATP binding site [chemical binding]; other site
76869017039	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
76869017040	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
76869017041	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
76869017042	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
76869017043	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
76869017044	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
76869017045	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
76869017046	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
76869017047	putative GTP cyclohydrolase; Provisional; Region: PRK13674
76869017048	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
76869017049	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
76869017050	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
76869017051	putative active site [active]
76869017052	catalytic site [active]
76869017053	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
76869017054	putative active site [active]
76869017055	catalytic site [active]
76869017056	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
76869017057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869017058	S-adenosylmethionine binding site [chemical binding]; other site
76869017059	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
76869017060	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
76869017061	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
76869017062	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
76869017063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
76869017064	Major Facilitator Superfamily; Region: MFS_1; pfam07690
76869017065	putative substrate translocation pore; other site
76869017066	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
76869017067	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
76869017068	substrate binding pocket [chemical binding]; other site
76869017069	active site
76869017070	iron coordination sites [ion binding]; other site
76869017071	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
76869017072	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
76869017073	Peptidase family M23; Region: Peptidase_M23; pfam01551
76869017074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
76869017075	Transposase; Region: HTH_Tnp_1; pfam01527
76869017076	putative transposase OrfB; Reviewed; Region: PHA02517
76869017077	HTH-like domain; Region: HTH_21; pfam13276
76869017078	Integrase core domain; Region: rve; pfam00665
76869017079	Integrase core domain; Region: rve_2; pfam13333
76869017080	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
76869017081	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
76869017082	glutaminase active site [active]
76869017083	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
76869017084	dimer interface [polypeptide binding]; other site
76869017085	active site
76869017086	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
76869017087	dimer interface [polypeptide binding]; other site
76869017088	active site
76869017089	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
76869017090	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
76869017091	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
76869017092	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
76869017093	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
76869017094	Substrate binding site; other site
76869017095	Mg++ binding site; other site
76869017096	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
76869017097	active site
76869017098	substrate binding site [chemical binding]; other site
76869017099	CoA binding site [chemical binding]; other site
76869017100	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
76869017101	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
76869017102	gamma subunit interface [polypeptide binding]; other site
76869017103	epsilon subunit interface [polypeptide binding]; other site
76869017104	LBP interface [polypeptide binding]; other site
76869017105	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
76869017106	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
76869017107	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
76869017108	alpha subunit interaction interface [polypeptide binding]; other site
76869017109	Walker A motif; other site
76869017110	ATP binding site [chemical binding]; other site
76869017111	Walker B motif; other site
76869017112	inhibitor binding site; inhibition site
76869017113	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
76869017114	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
76869017115	core domain interface [polypeptide binding]; other site
76869017116	delta subunit interface [polypeptide binding]; other site
76869017117	epsilon subunit interface [polypeptide binding]; other site
76869017118	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
76869017119	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
76869017120	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
76869017121	beta subunit interaction interface [polypeptide binding]; other site
76869017122	Walker A motif; other site
76869017123	ATP binding site [chemical binding]; other site
76869017124	Walker B motif; other site
76869017125	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
76869017126	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
76869017127	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
76869017128	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
76869017129	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
76869017130	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
76869017131	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
76869017132	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
76869017133	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
76869017134	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
76869017135	ParB-like nuclease domain; Region: ParBc; pfam02195
76869017136	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
76869017137	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
76869017138	P loop; other site
76869017139	Nucleotide binding site [chemical binding]; other site
76869017140	DTAP/Switch II; other site
76869017141	Switch I; other site
76869017142	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
76869017143	Magnesium ion binding site [ion binding]; other site
76869017144	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
76869017145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
76869017146	S-adenosylmethionine binding site [chemical binding]; other site
76869017147	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
76869017148	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
76869017149	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
76869017150	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
76869017151	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
76869017152	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
76869017153	trmE is a tRNA modification GTPase; Region: trmE; cd04164
76869017154	G1 box; other site
76869017155	GTP/Mg2+ binding site [chemical binding]; other site
76869017156	Switch I region; other site
76869017157	G2 box; other site
76869017158	Switch II region; other site
76869017159	G3 box; other site
76869017160	G4 box; other site
76869017161	G5 box; other site
76869017162	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
76869017163	membrane protein insertase; Provisional; Region: PRK01318
76869017164	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592