-- dump date 20140620_013606 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1207075000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1207075000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1207075000004 Walker A motif; other site 1207075000005 ATP binding site [chemical binding]; other site 1207075000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1207075000007 Walker B motif; other site 1207075000008 arginine finger; other site 1207075000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1207075000010 DnaA box-binding interface [nucleotide binding]; other site 1207075000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1207075000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1207075000013 putative DNA binding surface [nucleotide binding]; other site 1207075000014 dimer interface [polypeptide binding]; other site 1207075000015 beta-clamp/clamp loader binding surface; other site 1207075000016 beta-clamp/translesion DNA polymerase binding surface; other site 1207075000017 recombination protein F; Reviewed; Region: recF; PRK00064 1207075000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075000019 Walker A/P-loop; other site 1207075000020 ATP binding site [chemical binding]; other site 1207075000021 Q-loop/lid; other site 1207075000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075000023 ABC transporter signature motif; other site 1207075000024 Walker B; other site 1207075000025 D-loop; other site 1207075000026 H-loop/switch region; other site 1207075000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1207075000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075000029 Mg2+ binding site [ion binding]; other site 1207075000030 G-X-G motif; other site 1207075000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1207075000032 anchoring element; other site 1207075000033 dimer interface [polypeptide binding]; other site 1207075000034 ATP binding site [chemical binding]; other site 1207075000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1207075000036 active site 1207075000037 putative metal-binding site [ion binding]; other site 1207075000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1207075000039 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075000040 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1207075000041 putative acyl-acceptor binding pocket; other site 1207075000042 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1207075000043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075000044 active site 1207075000045 motif I; other site 1207075000046 motif II; other site 1207075000047 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1207075000048 HD domain; Region: HD; pfam01966 1207075000049 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1207075000050 dimer interface [polypeptide binding]; other site 1207075000051 motif 1; other site 1207075000052 active site 1207075000053 motif 2; other site 1207075000054 motif 3; other site 1207075000055 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1207075000056 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1207075000057 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1207075000058 putative acyl-acceptor binding pocket; other site 1207075000059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1207075000060 TPR motif; other site 1207075000061 binding surface 1207075000062 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1207075000063 TrkA-N domain; Region: TrkA_N; pfam02254 1207075000064 TrkA-C domain; Region: TrkA_C; pfam02080 1207075000065 TrkA-N domain; Region: TrkA_N; pfam02254 1207075000066 TrkA-C domain; Region: TrkA_C; pfam02080 1207075000067 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1207075000068 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1207075000069 putative RNA binding site [nucleotide binding]; other site 1207075000070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075000071 S-adenosylmethionine binding site [chemical binding]; other site 1207075000072 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1207075000073 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1207075000074 putative active site [active] 1207075000075 substrate binding site [chemical binding]; other site 1207075000076 putative cosubstrate binding site; other site 1207075000077 catalytic site [active] 1207075000078 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1207075000079 substrate binding site [chemical binding]; other site 1207075000080 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1207075000081 active site 1207075000082 catalytic residues [active] 1207075000083 metal binding site [ion binding]; metal-binding site 1207075000084 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1207075000085 DNA protecting protein DprA; Region: dprA; TIGR00732 1207075000086 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1207075000087 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1207075000088 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1207075000089 NADP binding site [chemical binding]; other site 1207075000090 dimer interface [polypeptide binding]; other site 1207075000091 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1207075000092 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1207075000093 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1207075000094 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1207075000095 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1207075000096 shikimate binding site; other site 1207075000097 NAD(P) binding site [chemical binding]; other site 1207075000098 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1207075000099 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1207075000100 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075000101 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075000102 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1207075000103 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075000104 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1207075000105 Sulfatase; Region: Sulfatase; cl17466 1207075000106 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1207075000107 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1207075000108 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1207075000109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075000110 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075000111 dimerization interface [polypeptide binding]; other site 1207075000112 substrate binding pocket [chemical binding]; other site 1207075000113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075000114 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1207075000115 NAD(P) binding site [chemical binding]; other site 1207075000116 active site 1207075000117 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1207075000118 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1207075000119 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1207075000120 Citrate transporter; Region: CitMHS; pfam03600 1207075000121 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1207075000122 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1207075000123 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1207075000124 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1207075000125 PhoU domain; Region: PhoU; pfam01895 1207075000126 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1207075000127 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1207075000128 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1207075000129 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1207075000130 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1207075000131 Permease; Region: Permease; pfam02405 1207075000132 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1207075000133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075000134 Walker A/P-loop; other site 1207075000135 ATP binding site [chemical binding]; other site 1207075000136 Q-loop/lid; other site 1207075000137 ABC transporter signature motif; other site 1207075000138 Walker B; other site 1207075000139 D-loop; other site 1207075000140 H-loop/switch region; other site 1207075000141 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1207075000142 mce related protein; Region: MCE; pfam02470 1207075000143 Protein of unknown function (DUF330); Region: DUF330; cl01135 1207075000144 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1207075000145 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1207075000146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075000147 motif II; other site 1207075000148 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1207075000149 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1207075000150 trimer interface [polypeptide binding]; other site 1207075000151 putative metal binding site [ion binding]; other site 1207075000152 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1207075000153 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1207075000154 active site 1207075000155 Zn binding site [ion binding]; other site 1207075000156 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1207075000157 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1207075000158 active site 1207075000159 catalytic residues [active] 1207075000160 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1207075000161 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1207075000162 active site clefts [active] 1207075000163 zinc binding site [ion binding]; other site 1207075000164 dimer interface [polypeptide binding]; other site 1207075000165 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1207075000166 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075000167 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1207075000168 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1207075000169 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1207075000170 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1207075000171 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1207075000172 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1207075000173 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1207075000174 Subunit I/III interface [polypeptide binding]; other site 1207075000175 D-pathway; other site 1207075000176 Subunit I/VIIc interface [polypeptide binding]; other site 1207075000177 Subunit I/IV interface [polypeptide binding]; other site 1207075000178 Subunit I/II interface [polypeptide binding]; other site 1207075000179 Low-spin heme (heme a) binding site [chemical binding]; other site 1207075000180 Subunit I/VIIa interface [polypeptide binding]; other site 1207075000181 Subunit I/VIa interface [polypeptide binding]; other site 1207075000182 Dimer interface; other site 1207075000183 Putative water exit pathway; other site 1207075000184 Binuclear center (heme a3/CuB) [ion binding]; other site 1207075000185 K-pathway; other site 1207075000186 Subunit I/Vb interface [polypeptide binding]; other site 1207075000187 Putative proton exit pathway; other site 1207075000188 Subunit I/VIb interface; other site 1207075000189 Subunit I/VIc interface [polypeptide binding]; other site 1207075000190 Electron transfer pathway; other site 1207075000191 Subunit I/VIIIb interface [polypeptide binding]; other site 1207075000192 Subunit I/VIIb interface [polypeptide binding]; other site 1207075000193 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1207075000194 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1207075000195 Subunit III/VIIa interface [polypeptide binding]; other site 1207075000196 Phospholipid binding site [chemical binding]; other site 1207075000197 Subunit I/III interface [polypeptide binding]; other site 1207075000198 Subunit III/VIb interface [polypeptide binding]; other site 1207075000199 Subunit III/VIa interface; other site 1207075000200 Subunit III/Vb interface [polypeptide binding]; other site 1207075000201 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1207075000202 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1207075000203 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1207075000204 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1207075000205 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1207075000206 UbiA prenyltransferase family; Region: UbiA; pfam01040 1207075000207 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1207075000208 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1207075000209 Cu(I) binding site [ion binding]; other site 1207075000210 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1207075000211 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1207075000212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000213 dimer interface [polypeptide binding]; other site 1207075000214 conserved gate region; other site 1207075000215 ABC-ATPase subunit interface; other site 1207075000216 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1207075000217 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1207075000218 Walker A/P-loop; other site 1207075000219 ATP binding site [chemical binding]; other site 1207075000220 Q-loop/lid; other site 1207075000221 ABC transporter signature motif; other site 1207075000222 Walker B; other site 1207075000223 D-loop; other site 1207075000224 H-loop/switch region; other site 1207075000225 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1207075000226 hydroperoxidase II; Provisional; Region: katE; PRK11249 1207075000227 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1207075000228 tetramer interface [polypeptide binding]; other site 1207075000229 heme binding pocket [chemical binding]; other site 1207075000230 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1207075000231 domain interactions; other site 1207075000232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1207075000233 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1207075000234 dimer interface [polypeptide binding]; other site 1207075000235 putative PBP binding regions; other site 1207075000236 ABC-ATPase subunit interface; other site 1207075000237 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1207075000238 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1207075000239 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1207075000240 metal binding site 2 [ion binding]; metal-binding site 1207075000241 putative DNA binding helix; other site 1207075000242 metal binding site 1 [ion binding]; metal-binding site 1207075000243 dimer interface [polypeptide binding]; other site 1207075000244 structural Zn2+ binding site [ion binding]; other site 1207075000245 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1207075000246 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1207075000247 metal binding site [ion binding]; metal-binding site 1207075000248 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1207075000249 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1207075000250 putative active site [active] 1207075000251 putative substrate binding site [chemical binding]; other site 1207075000252 ATP binding site [chemical binding]; other site 1207075000253 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1207075000254 DNA polymerase I; Provisional; Region: PRK05755 1207075000255 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1207075000256 active site 1207075000257 metal binding site 1 [ion binding]; metal-binding site 1207075000258 putative 5' ssDNA interaction site; other site 1207075000259 metal binding site 3; metal-binding site 1207075000260 metal binding site 2 [ion binding]; metal-binding site 1207075000261 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1207075000262 putative DNA binding site [nucleotide binding]; other site 1207075000263 putative metal binding site [ion binding]; other site 1207075000264 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1207075000265 active site 1207075000266 catalytic site [active] 1207075000267 substrate binding site [chemical binding]; other site 1207075000268 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1207075000269 active site 1207075000270 DNA binding site [nucleotide binding] 1207075000271 catalytic site [active] 1207075000272 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1207075000273 G1 box; other site 1207075000274 GTP/Mg2+ binding site [chemical binding]; other site 1207075000275 Switch I region; other site 1207075000276 G2 box; other site 1207075000277 G3 box; other site 1207075000278 Switch II region; other site 1207075000279 G4 box; other site 1207075000280 G5 box; other site 1207075000281 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1207075000282 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1207075000283 Cytochrome c; Region: Cytochrom_C; cl11414 1207075000284 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1207075000285 catalytic residues [active] 1207075000286 hinge region; other site 1207075000287 alpha helical domain; other site 1207075000288 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1207075000289 putative catalytic site [active] 1207075000290 putative metal binding site [ion binding]; other site 1207075000291 putative phosphate binding site [ion binding]; other site 1207075000292 putative catalytic site [active] 1207075000293 putative phosphate binding site [ion binding]; other site 1207075000294 putative metal binding site [ion binding]; other site 1207075000295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075000296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075000297 metal binding site [ion binding]; metal-binding site 1207075000298 active site 1207075000299 I-site; other site 1207075000300 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1207075000301 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1207075000302 amidase catalytic site [active] 1207075000303 Zn binding residues [ion binding]; other site 1207075000304 substrate binding site [chemical binding]; other site 1207075000305 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1207075000306 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1207075000307 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1207075000308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075000309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075000310 dimerization interface [polypeptide binding]; other site 1207075000311 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1207075000312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075000313 putative active site [active] 1207075000314 heme pocket [chemical binding]; other site 1207075000315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075000316 dimer interface [polypeptide binding]; other site 1207075000317 phosphorylation site [posttranslational modification] 1207075000318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075000319 ATP binding site [chemical binding]; other site 1207075000320 Mg2+ binding site [ion binding]; other site 1207075000321 G-X-G motif; other site 1207075000322 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075000323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075000324 active site 1207075000325 phosphorylation site [posttranslational modification] 1207075000326 intermolecular recognition site; other site 1207075000327 dimerization interface [polypeptide binding]; other site 1207075000328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075000329 Walker A motif; other site 1207075000330 ATP binding site [chemical binding]; other site 1207075000331 Walker B motif; other site 1207075000332 arginine finger; other site 1207075000333 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075000334 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1207075000335 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075000336 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1207075000337 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1207075000338 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1207075000339 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1207075000340 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1207075000341 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1207075000342 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1207075000343 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1207075000344 Dodecin; Region: Dodecin; pfam07311 1207075000345 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1207075000346 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075000347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075000348 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 1207075000349 putative dimerization interface [polypeptide binding]; other site 1207075000350 putative substrate binding pocket [chemical binding]; other site 1207075000351 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1207075000352 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1207075000353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075000354 catalytic residue [active] 1207075000355 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1207075000356 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1207075000357 substrate binding site [chemical binding]; other site 1207075000358 active site 1207075000359 catalytic residues [active] 1207075000360 heterodimer interface [polypeptide binding]; other site 1207075000361 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1207075000362 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1207075000363 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1207075000364 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1207075000365 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1207075000366 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1207075000367 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1207075000368 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1207075000369 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1207075000370 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1207075000371 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1207075000372 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1207075000373 ligand binding site [chemical binding]; other site 1207075000374 homodimer interface [polypeptide binding]; other site 1207075000375 NAD(P) binding site [chemical binding]; other site 1207075000376 trimer interface B [polypeptide binding]; other site 1207075000377 trimer interface A [polypeptide binding]; other site 1207075000378 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075000379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075000380 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1207075000381 dimerization interface [polypeptide binding]; other site 1207075000382 substrate binding pocket [chemical binding]; other site 1207075000383 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1207075000384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075000385 FAD binding site [chemical binding]; other site 1207075000386 substrate binding pocket [chemical binding]; other site 1207075000387 catalytic base [active] 1207075000388 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075000389 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075000390 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1207075000391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075000392 DNA-binding site [nucleotide binding]; DNA binding site 1207075000393 FCD domain; Region: FCD; pfam07729 1207075000394 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1207075000395 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1207075000396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075000397 dimerization interface [polypeptide binding]; other site 1207075000398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075000399 metal binding site [ion binding]; metal-binding site 1207075000400 active site 1207075000401 I-site; other site 1207075000402 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075000403 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1207075000404 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1207075000405 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1207075000406 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075000407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075000408 Walker A/P-loop; other site 1207075000409 ATP binding site [chemical binding]; other site 1207075000410 Q-loop/lid; other site 1207075000411 ABC transporter signature motif; other site 1207075000412 Walker B; other site 1207075000413 D-loop; other site 1207075000414 H-loop/switch region; other site 1207075000415 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1207075000416 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075000417 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075000418 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1207075000419 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1207075000420 active site 1207075000421 iron coordination sites [ion binding]; other site 1207075000422 substrate binding pocket [chemical binding]; other site 1207075000423 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1207075000424 NMT1-like family; Region: NMT1_2; pfam13379 1207075000425 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1207075000426 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075000427 Walker A/P-loop; other site 1207075000428 ATP binding site [chemical binding]; other site 1207075000429 Q-loop/lid; other site 1207075000430 ABC transporter signature motif; other site 1207075000431 Walker B; other site 1207075000432 D-loop; other site 1207075000433 H-loop/switch region; other site 1207075000434 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1207075000435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000436 dimer interface [polypeptide binding]; other site 1207075000437 conserved gate region; other site 1207075000438 putative PBP binding loops; other site 1207075000439 ABC-ATPase subunit interface; other site 1207075000440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075000441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075000442 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1207075000443 putative substrate binding pocket [chemical binding]; other site 1207075000444 putative dimerization interface [polypeptide binding]; other site 1207075000445 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1207075000446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075000447 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1207075000448 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075000449 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1207075000450 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1207075000451 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1207075000452 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1207075000453 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1207075000454 putative deacylase active site [active] 1207075000455 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1207075000456 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1207075000457 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1207075000458 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1207075000459 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1207075000460 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1207075000461 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075000462 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1207075000463 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1207075000464 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075000465 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075000466 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1207075000467 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1207075000468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1207075000469 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 1207075000470 [2Fe-2S] cluster binding site [ion binding]; other site 1207075000471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1207075000472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075000473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075000474 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1207075000475 substrate binding site [chemical binding]; other site 1207075000476 CHASE2 domain; Region: CHASE2; cl01732 1207075000477 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1207075000478 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1207075000479 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1207075000480 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1207075000481 tetramerization interface [polypeptide binding]; other site 1207075000482 NAD(P) binding site [chemical binding]; other site 1207075000483 catalytic residues [active] 1207075000484 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1207075000485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075000486 inhibitor-cofactor binding pocket; inhibition site 1207075000487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075000488 catalytic residue [active] 1207075000489 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075000490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075000491 active site 1207075000492 phosphorylation site [posttranslational modification] 1207075000493 intermolecular recognition site; other site 1207075000494 dimerization interface [polypeptide binding]; other site 1207075000495 HDOD domain; Region: HDOD; pfam08668 1207075000496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1207075000497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075000498 Transposase; Region: HTH_Tnp_1; pfam01527 1207075000499 putative transposase OrfB; Reviewed; Region: PHA02517 1207075000500 HTH-like domain; Region: HTH_21; pfam13276 1207075000501 Integrase core domain; Region: rve; pfam00665 1207075000502 Integrase core domain; Region: rve_3; pfam13683 1207075000503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075000504 PAS fold; Region: PAS_3; pfam08447 1207075000505 putative active site [active] 1207075000506 heme pocket [chemical binding]; other site 1207075000507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075000508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075000509 metal binding site [ion binding]; metal-binding site 1207075000510 active site 1207075000511 I-site; other site 1207075000512 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1207075000513 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1207075000514 Di-iron ligands [ion binding]; other site 1207075000515 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1207075000516 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1207075000517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075000518 PAS domain; Region: PAS_9; pfam13426 1207075000519 putative active site [active] 1207075000520 heme pocket [chemical binding]; other site 1207075000521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075000522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075000523 metal binding site [ion binding]; metal-binding site 1207075000524 active site 1207075000525 I-site; other site 1207075000526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075000527 Uncharacterized small protein [Function unknown]; Region: COG5583 1207075000528 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1207075000529 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1207075000530 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1207075000531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000532 dimer interface [polypeptide binding]; other site 1207075000533 conserved gate region; other site 1207075000534 putative PBP binding loops; other site 1207075000535 ABC-ATPase subunit interface; other site 1207075000536 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1207075000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000538 dimer interface [polypeptide binding]; other site 1207075000539 conserved gate region; other site 1207075000540 putative PBP binding loops; other site 1207075000541 ABC-ATPase subunit interface; other site 1207075000542 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1207075000543 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1207075000544 Walker A/P-loop; other site 1207075000545 ATP binding site [chemical binding]; other site 1207075000546 Q-loop/lid; other site 1207075000547 ABC transporter signature motif; other site 1207075000548 Walker B; other site 1207075000549 D-loop; other site 1207075000550 H-loop/switch region; other site 1207075000551 TOBE-like domain; Region: TOBE_3; pfam12857 1207075000552 Predicted membrane protein [Function unknown]; Region: COG4539 1207075000553 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1207075000554 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075000555 ligand binding site [chemical binding]; other site 1207075000556 flexible hinge region; other site 1207075000557 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1207075000558 non-specific DNA interactions [nucleotide binding]; other site 1207075000559 DNA binding site [nucleotide binding] 1207075000560 sequence specific DNA binding site [nucleotide binding]; other site 1207075000561 putative cAMP binding site [chemical binding]; other site 1207075000562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1207075000563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075000564 non-specific DNA binding site [nucleotide binding]; other site 1207075000565 salt bridge; other site 1207075000566 sequence-specific DNA binding site [nucleotide binding]; other site 1207075000567 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1207075000568 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1207075000569 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1207075000570 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1207075000571 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075000572 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075000573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075000574 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1207075000575 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075000576 Sulfatase; Region: Sulfatase; pfam00884 1207075000577 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1207075000578 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075000579 Walker A/P-loop; other site 1207075000580 ATP binding site [chemical binding]; other site 1207075000581 Q-loop/lid; other site 1207075000582 ABC transporter signature motif; other site 1207075000583 Walker B; other site 1207075000584 D-loop; other site 1207075000585 H-loop/switch region; other site 1207075000586 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1207075000587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1207075000588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1207075000589 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1207075000590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1207075000591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075000592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075000593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075000594 dimerization interface [polypeptide binding]; other site 1207075000595 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1207075000596 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1207075000597 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1207075000598 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075000599 N-terminal plug; other site 1207075000600 ligand-binding site [chemical binding]; other site 1207075000601 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1207075000602 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1207075000603 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1207075000604 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1207075000605 TolR protein; Region: tolR; TIGR02801 1207075000606 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1207075000607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075000608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075000609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1207075000610 Walker A motif; other site 1207075000611 ATP binding site [chemical binding]; other site 1207075000612 Walker B motif; other site 1207075000613 arginine finger; other site 1207075000614 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1207075000615 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1207075000616 Predicted ATPase [General function prediction only]; Region: COG4637 1207075000617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075000618 Walker A/P-loop; other site 1207075000619 ATP binding site [chemical binding]; other site 1207075000620 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075000621 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075000622 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075000623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075000624 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1207075000625 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1207075000626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075000627 S-adenosylmethionine binding site [chemical binding]; other site 1207075000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000629 dimer interface [polypeptide binding]; other site 1207075000630 conserved gate region; other site 1207075000631 ABC-ATPase subunit interface; other site 1207075000632 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1207075000633 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1207075000634 Walker A/P-loop; other site 1207075000635 ATP binding site [chemical binding]; other site 1207075000636 Q-loop/lid; other site 1207075000637 ABC transporter signature motif; other site 1207075000638 Walker B; other site 1207075000639 D-loop; other site 1207075000640 H-loop/switch region; other site 1207075000641 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1207075000642 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1207075000643 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1207075000644 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1207075000645 active site 1207075000646 non-prolyl cis peptide bond; other site 1207075000647 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1207075000648 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1207075000649 Flavin binding site [chemical binding]; other site 1207075000650 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1207075000651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075000652 active site 1207075000653 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1207075000654 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075000655 Walker A/P-loop; other site 1207075000656 ATP binding site [chemical binding]; other site 1207075000657 Q-loop/lid; other site 1207075000658 ABC transporter signature motif; other site 1207075000659 Walker B; other site 1207075000660 D-loop; other site 1207075000661 H-loop/switch region; other site 1207075000662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000663 dimer interface [polypeptide binding]; other site 1207075000664 conserved gate region; other site 1207075000665 putative PBP binding loops; other site 1207075000666 ABC-ATPase subunit interface; other site 1207075000667 cystine transporter subunit; Provisional; Region: PRK11260 1207075000668 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075000669 substrate binding pocket [chemical binding]; other site 1207075000670 membrane-bound complex binding site; other site 1207075000671 hinge residues; other site 1207075000672 D-cysteine desulfhydrase; Validated; Region: PRK03910 1207075000673 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1207075000674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075000675 catalytic residue [active] 1207075000676 serine O-acetyltransferase; Region: cysE; TIGR01172 1207075000677 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1207075000678 trimer interface [polypeptide binding]; other site 1207075000679 active site 1207075000680 substrate binding site [chemical binding]; other site 1207075000681 CoA binding site [chemical binding]; other site 1207075000682 BCCT family transporter; Region: BCCT; cl00569 1207075000683 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1207075000684 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1207075000685 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1207075000686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000687 dimer interface [polypeptide binding]; other site 1207075000688 conserved gate region; other site 1207075000689 putative PBP binding loops; other site 1207075000690 ABC-ATPase subunit interface; other site 1207075000691 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1207075000692 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075000693 Walker A/P-loop; other site 1207075000694 ATP binding site [chemical binding]; other site 1207075000695 Q-loop/lid; other site 1207075000696 ABC transporter signature motif; other site 1207075000697 Walker B; other site 1207075000698 D-loop; other site 1207075000699 H-loop/switch region; other site 1207075000700 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1207075000701 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075000702 substrate binding pocket [chemical binding]; other site 1207075000703 membrane-bound complex binding site; other site 1207075000704 hinge residues; other site 1207075000705 glutamate--cysteine ligase; Provisional; Region: PRK02107 1207075000706 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075000707 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1207075000708 CoenzymeA binding site [chemical binding]; other site 1207075000709 subunit interaction site [polypeptide binding]; other site 1207075000710 PHB binding site; other site 1207075000711 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1207075000712 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1207075000713 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1207075000714 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1207075000715 RNA binding site [nucleotide binding]; other site 1207075000716 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1207075000717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075000718 active site 1207075000719 phosphorylation site [posttranslational modification] 1207075000720 intermolecular recognition site; other site 1207075000721 dimerization interface [polypeptide binding]; other site 1207075000722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075000723 DNA binding site [nucleotide binding] 1207075000724 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1207075000725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075000726 dimerization interface [polypeptide binding]; other site 1207075000727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075000728 ATP binding site [chemical binding]; other site 1207075000729 Mg2+ binding site [ion binding]; other site 1207075000730 G-X-G motif; other site 1207075000731 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1207075000732 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1207075000733 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1207075000734 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075000735 RNA binding surface [nucleotide binding]; other site 1207075000736 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1207075000737 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1207075000738 dimerization interface [polypeptide binding]; other site 1207075000739 domain crossover interface; other site 1207075000740 redox-dependent activation switch; other site 1207075000741 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1207075000742 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1207075000743 active site 1207075000744 substrate-binding site [chemical binding]; other site 1207075000745 metal-binding site [ion binding] 1207075000746 ATP binding site [chemical binding]; other site 1207075000747 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1207075000748 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1207075000749 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1207075000750 Helix-turn-helix domain; Region: HTH_31; pfam13560 1207075000751 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1207075000752 catalytic triad [active] 1207075000753 putative active site [active] 1207075000754 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1207075000755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075000756 ATP binding site [chemical binding]; other site 1207075000757 putative Mg++ binding site [ion binding]; other site 1207075000758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075000759 nucleotide binding region [chemical binding]; other site 1207075000760 ATP-binding site [chemical binding]; other site 1207075000761 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1207075000762 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1207075000763 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1207075000764 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1207075000765 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1207075000766 active site 1207075000767 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1207075000768 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1207075000769 putative molybdopterin cofactor binding site [chemical binding]; other site 1207075000770 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1207075000771 putative molybdopterin cofactor binding site; other site 1207075000772 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1207075000773 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1207075000774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075000775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075000776 dimerization interface [polypeptide binding]; other site 1207075000777 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1207075000778 BON domain; Region: BON; pfam04972 1207075000779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1207075000780 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1207075000781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075000782 motif II; other site 1207075000783 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1207075000784 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1207075000785 dimer interface [polypeptide binding]; other site 1207075000786 ADP-ribose binding site [chemical binding]; other site 1207075000787 active site 1207075000788 nudix motif; other site 1207075000789 metal binding site [ion binding]; metal-binding site 1207075000790 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1207075000791 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1207075000792 active site 1207075000793 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1207075000794 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075000795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075000796 active site 1207075000797 phosphorylation site [posttranslational modification] 1207075000798 intermolecular recognition site; other site 1207075000799 dimerization interface [polypeptide binding]; other site 1207075000800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075000801 Walker A motif; other site 1207075000802 ATP binding site [chemical binding]; other site 1207075000803 Walker B motif; other site 1207075000804 arginine finger; other site 1207075000805 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075000806 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1207075000807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075000808 dimer interface [polypeptide binding]; other site 1207075000809 phosphorylation site [posttranslational modification] 1207075000810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075000811 ATP binding site [chemical binding]; other site 1207075000812 G-X-G motif; other site 1207075000813 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1207075000814 hypothetical protein; Provisional; Region: PRK06149 1207075000815 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1207075000816 active site 1207075000817 ATP binding site [chemical binding]; other site 1207075000818 substrate binding site [chemical binding]; other site 1207075000819 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075000820 inhibitor-cofactor binding pocket; inhibition site 1207075000821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075000822 catalytic residue [active] 1207075000823 agmatine deiminase; Provisional; Region: PRK13551 1207075000824 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1207075000825 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1207075000826 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075000827 N-terminal plug; other site 1207075000828 ligand-binding site [chemical binding]; other site 1207075000829 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1207075000830 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1207075000831 catalytic residues [active] 1207075000832 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075000833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075000834 salt bridge; other site 1207075000835 non-specific DNA binding site [nucleotide binding]; other site 1207075000836 sequence-specific DNA binding site [nucleotide binding]; other site 1207075000837 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1207075000838 active site 1 [active] 1207075000839 dimer interface [polypeptide binding]; other site 1207075000840 hexamer interface [polypeptide binding]; other site 1207075000841 active site 2 [active] 1207075000842 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1207075000843 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1207075000844 catalytic residues [active] 1207075000845 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1207075000846 classical (c) SDRs; Region: SDR_c; cd05233 1207075000847 NAD(P) binding site [chemical binding]; other site 1207075000848 active site 1207075000849 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1207075000850 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1207075000851 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075000852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000853 dimer interface [polypeptide binding]; other site 1207075000854 conserved gate region; other site 1207075000855 putative PBP binding loops; other site 1207075000856 ABC-ATPase subunit interface; other site 1207075000857 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075000858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075000859 dimer interface [polypeptide binding]; other site 1207075000860 conserved gate region; other site 1207075000861 putative PBP binding loops; other site 1207075000862 ABC-ATPase subunit interface; other site 1207075000863 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075000864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075000865 substrate binding pocket [chemical binding]; other site 1207075000866 membrane-bound complex binding site; other site 1207075000867 hinge residues; other site 1207075000868 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1207075000869 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075000870 Walker A/P-loop; other site 1207075000871 ATP binding site [chemical binding]; other site 1207075000872 Q-loop/lid; other site 1207075000873 ABC transporter signature motif; other site 1207075000874 Walker B; other site 1207075000875 D-loop; other site 1207075000876 H-loop/switch region; other site 1207075000877 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1207075000878 Spore germination protein; Region: Spore_permease; cl17796 1207075000879 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1207075000880 oligomeric interface; other site 1207075000881 putative active site [active] 1207075000882 homodimer interface [polypeptide binding]; other site 1207075000883 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1207075000884 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1207075000885 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075000886 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1207075000887 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1207075000888 hypothetical protein; Provisional; Region: PRK10621 1207075000889 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075000890 oxidative damage protection protein; Provisional; Region: PRK05408 1207075000891 adenine DNA glycosylase; Provisional; Region: PRK10880 1207075000892 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1207075000893 minor groove reading motif; other site 1207075000894 helix-hairpin-helix signature motif; other site 1207075000895 substrate binding pocket [chemical binding]; other site 1207075000896 active site 1207075000897 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1207075000898 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1207075000899 DNA binding and oxoG recognition site [nucleotide binding] 1207075000900 AsmA family; Region: AsmA; pfam05170 1207075000901 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1207075000902 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1207075000903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075000905 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1207075000906 putative active site pocket [active] 1207075000907 4-fold oligomerization interface [polypeptide binding]; other site 1207075000908 metal binding residues [ion binding]; metal-binding site 1207075000909 3-fold/trimer interface [polypeptide binding]; other site 1207075000910 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1207075000911 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1207075000912 putative active site [active] 1207075000913 oxyanion strand; other site 1207075000914 catalytic triad [active] 1207075000915 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1207075000916 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1207075000917 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1207075000918 catalytic residues [active] 1207075000919 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1207075000920 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1207075000921 substrate binding site [chemical binding]; other site 1207075000922 glutamase interaction surface [polypeptide binding]; other site 1207075000923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075000924 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075000925 substrate binding pocket [chemical binding]; other site 1207075000926 membrane-bound complex binding site; other site 1207075000927 hinge residues; other site 1207075000928 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1207075000929 NodB motif; other site 1207075000930 putative active site [active] 1207075000931 putative catalytic site [active] 1207075000932 Zn binding site [ion binding]; other site 1207075000933 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1207075000934 C-terminal peptidase (prc); Region: prc; TIGR00225 1207075000935 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1207075000936 protein binding site [polypeptide binding]; other site 1207075000937 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1207075000938 Catalytic dyad [active] 1207075000939 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1207075000940 Peptidase family M23; Region: Peptidase_M23; pfam01551 1207075000941 phosphoglyceromutase; Provisional; Region: PRK05434 1207075000942 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1207075000943 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1207075000944 active site residue [active] 1207075000945 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1207075000946 GSH binding site [chemical binding]; other site 1207075000947 catalytic residues [active] 1207075000948 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1207075000949 SecA binding site; other site 1207075000950 Preprotein binding site; other site 1207075000951 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1207075000952 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1207075000953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075000954 active site 1207075000955 phosphorylation site [posttranslational modification] 1207075000956 intermolecular recognition site; other site 1207075000957 dimerization interface [polypeptide binding]; other site 1207075000958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075000959 Walker A motif; other site 1207075000960 ATP binding site [chemical binding]; other site 1207075000961 Walker B motif; other site 1207075000962 arginine finger; other site 1207075000963 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075000964 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1207075000965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075000966 putative active site [active] 1207075000967 heme pocket [chemical binding]; other site 1207075000968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075000969 dimer interface [polypeptide binding]; other site 1207075000970 phosphorylation site [posttranslational modification] 1207075000971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075000972 ATP binding site [chemical binding]; other site 1207075000973 Mg2+ binding site [ion binding]; other site 1207075000974 G-X-G motif; other site 1207075000975 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1207075000976 glutamine synthetase; Provisional; Region: glnA; PRK09469 1207075000977 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1207075000978 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075000979 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1207075000980 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1207075000981 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1207075000982 Ligand Binding Site [chemical binding]; other site 1207075000983 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 1207075000984 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1207075000985 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1207075000986 G1 box; other site 1207075000987 putative GEF interaction site [polypeptide binding]; other site 1207075000988 GTP/Mg2+ binding site [chemical binding]; other site 1207075000989 Switch I region; other site 1207075000990 G2 box; other site 1207075000991 G3 box; other site 1207075000992 Switch II region; other site 1207075000993 G4 box; other site 1207075000994 G5 box; other site 1207075000995 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1207075000996 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1207075000997 Flagellin N-methylase; Region: FliB; pfam03692 1207075000998 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1207075000999 homodimer interface [polypeptide binding]; other site 1207075001000 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1207075001001 active site pocket [active] 1207075001002 Predicted membrane protein [Function unknown]; Region: COG5373 1207075001003 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1207075001004 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1207075001005 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1207075001006 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1207075001007 AMP binding site [chemical binding]; other site 1207075001008 metal binding site [ion binding]; metal-binding site 1207075001009 active site 1207075001010 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1207075001011 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 1207075001012 Cache domain; Region: Cache_1; pfam02743 1207075001013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075001014 dimerization interface [polypeptide binding]; other site 1207075001015 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075001016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001017 dimer interface [polypeptide binding]; other site 1207075001018 putative CheW interface [polypeptide binding]; other site 1207075001019 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1207075001020 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1207075001021 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1207075001022 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1207075001023 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1207075001024 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1207075001025 active site 1207075001026 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1207075001027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075001028 DNA-binding site [nucleotide binding]; DNA binding site 1207075001029 UTRA domain; Region: UTRA; pfam07702 1207075001030 HutD; Region: HutD; pfam05962 1207075001031 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1207075001032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001033 dimer interface [polypeptide binding]; other site 1207075001034 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1207075001035 putative CheW interface [polypeptide binding]; other site 1207075001036 urocanate hydratase; Provisional; Region: PRK05414 1207075001037 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075001038 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1207075001039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075001040 dimer interface [polypeptide binding]; other site 1207075001041 conserved gate region; other site 1207075001042 putative PBP binding loops; other site 1207075001043 ABC-ATPase subunit interface; other site 1207075001044 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1207075001045 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1207075001046 Walker A/P-loop; other site 1207075001047 ATP binding site [chemical binding]; other site 1207075001048 Q-loop/lid; other site 1207075001049 ABC transporter signature motif; other site 1207075001050 Walker B; other site 1207075001051 D-loop; other site 1207075001052 H-loop/switch region; other site 1207075001053 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1207075001054 active sites [active] 1207075001055 tetramer interface [polypeptide binding]; other site 1207075001056 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1207075001057 active sites [active] 1207075001058 tetramer interface [polypeptide binding]; other site 1207075001059 putative proline-specific permease; Provisional; Region: proY; PRK10580 1207075001060 Spore germination protein; Region: Spore_permease; cl17796 1207075001061 imidazolonepropionase; Validated; Region: PRK09356 1207075001062 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1207075001063 active site 1207075001064 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1207075001065 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075001066 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1207075001067 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1207075001068 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075001069 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1207075001070 TAP-like protein; Region: Abhydrolase_4; pfam08386 1207075001071 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1207075001072 putative active site [active] 1207075001073 dimerization interface [polypeptide binding]; other site 1207075001074 putative tRNAtyr binding site [nucleotide binding]; other site 1207075001075 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1207075001076 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1207075001077 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075001078 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1207075001079 Ligand binding site; other site 1207075001080 DXD motif; other site 1207075001081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075001082 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075001083 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075001084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075001085 dimerization interface [polypeptide binding]; other site 1207075001086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075001087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001088 dimer interface [polypeptide binding]; other site 1207075001089 putative CheW interface [polypeptide binding]; other site 1207075001090 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1207075001091 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1207075001092 sec-independent translocase; Provisional; Region: tatB; PRK00404 1207075001093 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1207075001094 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1207075001095 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1207075001096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1207075001097 metal binding site [ion binding]; metal-binding site 1207075001098 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1207075001099 ABC1 family; Region: ABC1; cl17513 1207075001100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1207075001101 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1207075001102 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1207075001103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075001104 S-adenosylmethionine binding site [chemical binding]; other site 1207075001105 putative polyhydroxyalkanoic acid system protein; Region: PHA_gran_rgn; TIGR02610 1207075001106 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1207075001107 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1207075001108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075001109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075001110 Bacterial transcriptional repressor; Region: TetR; pfam13972 1207075001111 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1207075001112 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1207075001113 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1207075001114 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1207075001115 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1207075001116 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1207075001117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1207075001118 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1207075001119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075001120 Walker A motif; other site 1207075001121 ATP binding site [chemical binding]; other site 1207075001122 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1207075001123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1207075001124 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1207075001125 active site 1207075001126 HslU subunit interaction site [polypeptide binding]; other site 1207075001127 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1207075001128 Sporulation related domain; Region: SPOR; pfam05036 1207075001129 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1207075001130 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1207075001131 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1207075001132 active site 1207075001133 HIGH motif; other site 1207075001134 KMSK motif region; other site 1207075001135 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1207075001136 tRNA binding surface [nucleotide binding]; other site 1207075001137 anticodon binding site; other site 1207075001138 primosome assembly protein PriA; Validated; Region: PRK05580 1207075001139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075001140 ATP binding site [chemical binding]; other site 1207075001141 putative Mg++ binding site [ion binding]; other site 1207075001142 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1207075001143 ATP-binding site [chemical binding]; other site 1207075001144 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1207075001145 Staphylococcal nuclease homologues; Region: SNc; smart00318 1207075001146 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1207075001147 Catalytic site; other site 1207075001148 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1207075001149 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1207075001150 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1207075001151 putative NAD(P) binding site [chemical binding]; other site 1207075001152 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1207075001153 Transglycosylase; Region: Transgly; pfam00912 1207075001154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1207075001155 Competence protein A; Region: Competence_A; pfam11104 1207075001156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1207075001157 nucleotide binding site [chemical binding]; other site 1207075001158 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1207075001159 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1207075001160 Pilus assembly protein, PilO; Region: PilO; pfam04350 1207075001161 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1207075001162 Pilus assembly protein, PilP; Region: PilP; pfam04351 1207075001163 AMIN domain; Region: AMIN; pfam11741 1207075001164 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1207075001165 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075001166 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1207075001167 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1207075001168 shikimate kinase; Reviewed; Region: aroK; PRK00131 1207075001169 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1207075001170 ADP binding site [chemical binding]; other site 1207075001171 magnesium binding site [ion binding]; other site 1207075001172 putative shikimate binding site; other site 1207075001173 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1207075001174 active site 1207075001175 dimer interface [polypeptide binding]; other site 1207075001176 metal binding site [ion binding]; metal-binding site 1207075001177 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1207075001178 AAA ATPase domain; Region: AAA_16; pfam13191 1207075001179 Sporulation related domain; Region: SPOR; pfam05036 1207075001180 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1207075001181 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1207075001182 active site 1207075001183 dimer interface [polypeptide binding]; other site 1207075001184 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1207075001185 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1207075001186 active site 1207075001187 FMN binding site [chemical binding]; other site 1207075001188 substrate binding site [chemical binding]; other site 1207075001189 3Fe-4S cluster binding site [ion binding]; other site 1207075001190 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1207075001191 domain interface; other site 1207075001192 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1207075001193 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1207075001194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075001195 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1207075001196 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1207075001197 substrate binding site [chemical binding]; other site 1207075001198 active site 1207075001199 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075001200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075001201 putative substrate translocation pore; other site 1207075001202 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1207075001203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075001204 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1207075001205 dimerization interface [polypeptide binding]; other site 1207075001206 substrate binding pocket [chemical binding]; other site 1207075001207 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1207075001208 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1207075001209 dimer interface [polypeptide binding]; other site 1207075001210 active site 1207075001211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075001212 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1207075001213 NAD(P) binding site [chemical binding]; other site 1207075001214 active site 1207075001215 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1207075001216 putative active site 1 [active] 1207075001217 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1207075001218 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1207075001219 dimer interface [polypeptide binding]; other site 1207075001220 active site 1207075001221 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1207075001222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075001223 S-adenosylmethionine binding site [chemical binding]; other site 1207075001224 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1207075001225 Predicted exporter [General function prediction only]; Region: COG4258 1207075001226 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1207075001227 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1207075001228 active site 1207075001229 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1207075001230 active sites [active] 1207075001231 tetramer interface [polypeptide binding]; other site 1207075001232 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1207075001233 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1207075001234 putative acyl-acceptor binding pocket; other site 1207075001235 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1207075001236 Ligand binding site; other site 1207075001237 Putative Catalytic site; other site 1207075001238 DXD motif; other site 1207075001239 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1207075001240 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075001241 active site 1207075001242 AMP binding site [chemical binding]; other site 1207075001243 acyl-activating enzyme (AAE) consensus motif; other site 1207075001244 CoA binding site [chemical binding]; other site 1207075001245 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1207075001246 active site 2 [active] 1207075001247 dimer interface [polypeptide binding]; other site 1207075001248 active site 1 [active] 1207075001249 Predicted membrane protein [Function unknown]; Region: COG4648 1207075001250 acyl carrier protein; Provisional; Region: PRK05350 1207075001251 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1207075001252 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1207075001253 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075001254 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1207075001255 putative acyl-acceptor binding pocket; other site 1207075001256 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1207075001257 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1207075001258 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075001259 P-loop; other site 1207075001260 Magnesium ion binding site [ion binding]; other site 1207075001261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075001262 Magnesium ion binding site [ion binding]; other site 1207075001263 thioredoxin 2; Provisional; Region: PRK10996 1207075001264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1207075001265 catalytic residues [active] 1207075001266 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1207075001267 hypothetical protein; Validated; Region: PRK00029 1207075001268 hypothetical protein; Provisional; Region: PRK11281 1207075001269 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 1207075001270 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1207075001271 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075001272 potassium/proton antiporter; Reviewed; Region: PRK05326 1207075001273 TrkA-C domain; Region: TrkA_C; pfam02080 1207075001274 Transporter associated domain; Region: CorC_HlyC; smart01091 1207075001275 Cell division protein ZapA; Region: ZapA; pfam05164 1207075001276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075001277 dimerization interface [polypeptide binding]; other site 1207075001278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075001279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001280 dimer interface [polypeptide binding]; other site 1207075001281 putative CheW interface [polypeptide binding]; other site 1207075001282 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1207075001283 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1207075001284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075001285 active site 1207075001286 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1207075001287 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1207075001288 Predicted transcriptional regulator [Transcription]; Region: COG3905 1207075001289 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1207075001290 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1207075001291 Glutamate binding site [chemical binding]; other site 1207075001292 NAD binding site [chemical binding]; other site 1207075001293 catalytic residues [active] 1207075001294 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075001295 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1207075001296 Na binding site [ion binding]; other site 1207075001297 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 1207075001298 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1207075001299 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1207075001300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1207075001301 GAF domain; Region: GAF; pfam01590 1207075001302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075001303 PAS domain; Region: PAS_9; pfam13426 1207075001304 putative active site [active] 1207075001305 heme pocket [chemical binding]; other site 1207075001306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075001307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075001308 metal binding site [ion binding]; metal-binding site 1207075001309 active site 1207075001310 I-site; other site 1207075001311 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075001312 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1207075001313 putative active site [active] 1207075001314 putative metal binding site [ion binding]; other site 1207075001315 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075001316 E3 interaction surface; other site 1207075001317 lipoyl attachment site [posttranslational modification]; other site 1207075001318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075001319 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1207075001320 E3 interaction surface; other site 1207075001321 lipoyl attachment site [posttranslational modification]; other site 1207075001322 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075001323 E3 interaction surface; other site 1207075001324 lipoyl attachment site [posttranslational modification]; other site 1207075001325 e3 binding domain; Region: E3_binding; pfam02817 1207075001326 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1207075001327 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1207075001328 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1207075001329 dimer interface [polypeptide binding]; other site 1207075001330 TPP-binding site [chemical binding]; other site 1207075001331 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1207075001332 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1207075001333 metal binding triad; other site 1207075001334 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1207075001335 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1207075001336 metal binding triad; other site 1207075001337 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1207075001338 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1207075001339 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1207075001340 putative active site [active] 1207075001341 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1207075001342 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1207075001343 putative active site [active] 1207075001344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075001345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1207075001346 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1207075001347 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1207075001348 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1207075001349 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1207075001350 active site 1207075001351 ATP binding site [chemical binding]; other site 1207075001352 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1207075001353 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1207075001354 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1207075001355 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1207075001356 putative ADP-binding pocket [chemical binding]; other site 1207075001357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075001358 Mig-14; Region: Mig-14; pfam07395 1207075001359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1207075001360 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1207075001361 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1207075001362 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1207075001363 putative ADP-binding pocket [chemical binding]; other site 1207075001364 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075001365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075001366 active site 1207075001367 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1207075001368 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1207075001369 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1207075001370 active site 1207075001371 substrate binding site [chemical binding]; other site 1207075001372 ATP binding site [chemical binding]; other site 1207075001373 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1207075001374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075001375 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1207075001376 Walker A/P-loop; other site 1207075001377 ATP binding site [chemical binding]; other site 1207075001378 Q-loop/lid; other site 1207075001379 ABC transporter signature motif; other site 1207075001380 Walker B; other site 1207075001381 D-loop; other site 1207075001382 H-loop/switch region; other site 1207075001383 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1207075001384 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1207075001385 putative ribose interaction site [chemical binding]; other site 1207075001386 putative ADP binding site [chemical binding]; other site 1207075001387 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1207075001388 active site 1207075001389 nucleotide binding site [chemical binding]; other site 1207075001390 HIGH motif; other site 1207075001391 KMSKS motif; other site 1207075001392 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075001393 active site 1207075001394 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075001395 catalytic tetrad [active] 1207075001396 FAD dependent oxidoreductase; Region: DAO; pfam01266 1207075001397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075001398 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1207075001399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075001400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075001401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075001402 dimerization interface [polypeptide binding]; other site 1207075001403 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1207075001404 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1207075001405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1207075001406 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1207075001407 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1207075001408 ThiC-associated domain; Region: ThiC-associated; pfam13667 1207075001409 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1207075001410 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075001411 Na binding site [ion binding]; other site 1207075001412 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1207075001413 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1207075001414 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1207075001415 dimer interface [polypeptide binding]; other site 1207075001416 ADP-ribose binding site [chemical binding]; other site 1207075001417 active site 1207075001418 nudix motif; other site 1207075001419 metal binding site [ion binding]; metal-binding site 1207075001420 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1207075001421 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1207075001422 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1207075001423 active site 1207075001424 metal binding site [ion binding]; metal-binding site 1207075001425 hexamer interface [polypeptide binding]; other site 1207075001426 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1207075001427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075001428 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1207075001429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075001430 ATP binding site [chemical binding]; other site 1207075001431 Mg2+ binding site [ion binding]; other site 1207075001432 G-X-G motif; other site 1207075001433 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1207075001434 anchoring element; other site 1207075001435 dimer interface [polypeptide binding]; other site 1207075001436 ATP binding site [chemical binding]; other site 1207075001437 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1207075001438 active site 1207075001439 metal binding site [ion binding]; metal-binding site 1207075001440 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1207075001441 SdiA-regulated; Region: SdiA-regulated; cd09971 1207075001442 putative active site [active] 1207075001443 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1207075001444 catalytic motif [active] 1207075001445 Catalytic residue [active] 1207075001446 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1207075001447 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1207075001448 CAP-like domain; other site 1207075001449 active site 1207075001450 primary dimer interface [polypeptide binding]; other site 1207075001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1207075001452 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1207075001453 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 1207075001454 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1207075001455 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1207075001456 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1207075001457 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1207075001458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075001459 motif II; other site 1207075001460 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1207075001461 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1207075001462 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1207075001463 active site residue [active] 1207075001464 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1207075001465 active site residue [active] 1207075001466 HDOD domain; Region: HDOD; pfam08668 1207075001467 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1207075001468 flagellar motor protein MotA; Validated; Region: PRK09110 1207075001469 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1207075001470 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1207075001471 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075001472 ligand binding site [chemical binding]; other site 1207075001473 TIR domain; Region: TIR_2; pfam13676 1207075001474 Caspase domain; Region: Peptidase_C14; pfam00656 1207075001475 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1207075001476 GTPase RsgA; Reviewed; Region: PRK12288 1207075001477 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1207075001478 RNA binding site [nucleotide binding]; other site 1207075001479 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1207075001480 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1207075001481 GTP/Mg2+ binding site [chemical binding]; other site 1207075001482 G4 box; other site 1207075001483 G5 box; other site 1207075001484 G1 box; other site 1207075001485 Switch I region; other site 1207075001486 G2 box; other site 1207075001487 G3 box; other site 1207075001488 Switch II region; other site 1207075001489 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1207075001490 catalytic site [active] 1207075001491 putative active site [active] 1207075001492 putative substrate binding site [chemical binding]; other site 1207075001493 dimer interface [polypeptide binding]; other site 1207075001494 Predicted membrane protein [Function unknown]; Region: COG2860 1207075001495 UPF0126 domain; Region: UPF0126; pfam03458 1207075001496 UPF0126 domain; Region: UPF0126; pfam03458 1207075001497 epoxyqueuosine reductase; Region: TIGR00276 1207075001498 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1207075001499 putative carbohydrate kinase; Provisional; Region: PRK10565 1207075001500 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1207075001501 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1207075001502 putative substrate binding site [chemical binding]; other site 1207075001503 putative ATP binding site [chemical binding]; other site 1207075001504 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1207075001505 AMIN domain; Region: AMIN; pfam11741 1207075001506 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1207075001507 active site 1207075001508 metal binding site [ion binding]; metal-binding site 1207075001509 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1207075001510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1207075001511 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1207075001512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075001513 ATP binding site [chemical binding]; other site 1207075001514 Mg2+ binding site [ion binding]; other site 1207075001515 G-X-G motif; other site 1207075001516 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1207075001517 ATP binding site [chemical binding]; other site 1207075001518 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1207075001519 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1207075001520 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1207075001521 bacterial Hfq-like; Region: Hfq; cd01716 1207075001522 hexamer interface [polypeptide binding]; other site 1207075001523 Sm1 motif; other site 1207075001524 RNA binding site [nucleotide binding]; other site 1207075001525 Sm2 motif; other site 1207075001526 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1207075001527 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1207075001528 HflX GTPase family; Region: HflX; cd01878 1207075001529 G1 box; other site 1207075001530 GTP/Mg2+ binding site [chemical binding]; other site 1207075001531 Switch I region; other site 1207075001532 G2 box; other site 1207075001533 G3 box; other site 1207075001534 Switch II region; other site 1207075001535 G4 box; other site 1207075001536 G5 box; other site 1207075001537 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1207075001538 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1207075001539 HflK protein; Region: hflK; TIGR01933 1207075001540 FtsH protease regulator HflC; Provisional; Region: PRK11029 1207075001541 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1207075001542 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1207075001543 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1207075001544 dimer interface [polypeptide binding]; other site 1207075001545 motif 1; other site 1207075001546 active site 1207075001547 motif 2; other site 1207075001548 motif 3; other site 1207075001549 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1207075001550 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1207075001551 GDP-binding site [chemical binding]; other site 1207075001552 ACT binding site; other site 1207075001553 IMP binding site; other site 1207075001554 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1207075001555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075001556 dimerization interface [polypeptide binding]; other site 1207075001557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001558 dimer interface [polypeptide binding]; other site 1207075001559 putative CheW interface [polypeptide binding]; other site 1207075001560 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1207075001561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075001562 dimer interface [polypeptide binding]; other site 1207075001563 conserved gate region; other site 1207075001564 putative PBP binding loops; other site 1207075001565 ABC-ATPase subunit interface; other site 1207075001566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075001567 dimer interface [polypeptide binding]; other site 1207075001568 conserved gate region; other site 1207075001569 putative PBP binding loops; other site 1207075001570 ABC-ATPase subunit interface; other site 1207075001571 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1207075001572 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075001573 ribonuclease R; Region: RNase_R; TIGR02063 1207075001574 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1207075001575 RNB domain; Region: RNB; pfam00773 1207075001576 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1207075001577 RNA binding site [nucleotide binding]; other site 1207075001578 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1207075001579 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1207075001580 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1207075001581 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1207075001582 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1207075001583 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1207075001584 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1207075001585 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1207075001586 replicative DNA helicase; Provisional; Region: PRK05748 1207075001587 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1207075001588 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1207075001589 Walker A motif; other site 1207075001590 ATP binding site [chemical binding]; other site 1207075001591 Walker B motif; other site 1207075001592 DNA binding loops [nucleotide binding] 1207075001593 hypothetical protein; Provisional; Region: PRK01254 1207075001594 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1207075001595 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1207075001596 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1207075001597 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1207075001598 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1207075001599 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1207075001600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1207075001601 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1207075001602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1207075001603 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1207075001604 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1207075001605 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1207075001606 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1207075001607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075001608 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075001609 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075001610 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1207075001611 azurin; Region: azurin; TIGR02695 1207075001612 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1207075001613 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1207075001614 homodimer interface [polypeptide binding]; other site 1207075001615 NAD binding pocket [chemical binding]; other site 1207075001616 ATP binding pocket [chemical binding]; other site 1207075001617 Mg binding site [ion binding]; other site 1207075001618 active-site loop [active] 1207075001619 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1207075001620 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1207075001621 active site 1207075001622 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075001623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075001624 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1207075001625 dimerization interface [polypeptide binding]; other site 1207075001626 substrate binding pocket [chemical binding]; other site 1207075001627 aldehyde dehydrogenase family 7 member; Region: PLN02315 1207075001628 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1207075001629 tetrameric interface [polypeptide binding]; other site 1207075001630 NAD binding site [chemical binding]; other site 1207075001631 catalytic residues [active] 1207075001632 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075001633 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075001634 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1207075001635 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1207075001636 dimerization interface [polypeptide binding]; other site 1207075001637 ligand binding site [chemical binding]; other site 1207075001638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075001639 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1207075001640 TM-ABC transporter signature motif; other site 1207075001641 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1207075001642 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1207075001643 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1207075001644 TM-ABC transporter signature motif; other site 1207075001645 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1207075001646 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1207075001647 Walker A/P-loop; other site 1207075001648 ATP binding site [chemical binding]; other site 1207075001649 Q-loop/lid; other site 1207075001650 ABC transporter signature motif; other site 1207075001651 Walker B; other site 1207075001652 D-loop; other site 1207075001653 H-loop/switch region; other site 1207075001654 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1207075001655 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1207075001656 Walker A/P-loop; other site 1207075001657 ATP binding site [chemical binding]; other site 1207075001658 Q-loop/lid; other site 1207075001659 ABC transporter signature motif; other site 1207075001660 Walker B; other site 1207075001661 D-loop; other site 1207075001662 H-loop/switch region; other site 1207075001663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075001664 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1207075001665 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1207075001666 putative NAD(P) binding site [chemical binding]; other site 1207075001667 homotetramer interface [polypeptide binding]; other site 1207075001668 homodimer interface [polypeptide binding]; other site 1207075001669 active site 1207075001670 Cation efflux family; Region: Cation_efflux; cl00316 1207075001671 dimerization interface [polypeptide binding]; other site 1207075001672 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1207075001673 putative active cleft [active] 1207075001674 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1207075001675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075001676 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1207075001677 UreF; Region: UreF; pfam01730 1207075001678 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1207075001679 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1207075001680 dimer interface [polypeptide binding]; other site 1207075001681 catalytic residues [active] 1207075001682 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1207075001683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075001684 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1207075001685 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1207075001686 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1207075001687 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075001688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075001689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075001690 dimerization interface [polypeptide binding]; other site 1207075001691 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1207075001692 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075001693 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1207075001694 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1207075001695 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1207075001696 Lipase (class 2); Region: Lipase_2; pfam01674 1207075001697 EamA-like transporter family; Region: EamA; pfam00892 1207075001698 EamA-like transporter family; Region: EamA; pfam00892 1207075001699 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075001700 Helix-turn-helix domain; Region: HTH_18; pfam12833 1207075001701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075001702 hypothetical protein; Provisional; Region: PRK11505 1207075001703 psiF repeat; Region: PsiF_repeat; pfam07769 1207075001704 psiF repeat; Region: PsiF_repeat; pfam07769 1207075001705 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1207075001706 putative chaperone; Provisional; Region: PRK11678 1207075001707 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1207075001708 nucleotide binding site [chemical binding]; other site 1207075001709 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1207075001710 SBD interface [polypeptide binding]; other site 1207075001711 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1207075001712 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1207075001713 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1207075001714 substrate binding site [polypeptide binding]; other site 1207075001715 dimer interface [polypeptide binding]; other site 1207075001716 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1207075001717 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1207075001718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075001719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075001720 dimer interface [polypeptide binding]; other site 1207075001721 phosphorylation site [posttranslational modification] 1207075001722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075001723 ATP binding site [chemical binding]; other site 1207075001724 Mg2+ binding site [ion binding]; other site 1207075001725 G-X-G motif; other site 1207075001726 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1207075001727 Leucine rich repeat; Region: LRR_8; pfam13855 1207075001728 Leucine rich repeat; Region: LRR_8; pfam13855 1207075001729 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1207075001730 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1207075001731 subunit interactions [polypeptide binding]; other site 1207075001732 active site 1207075001733 flap region; other site 1207075001734 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1207075001735 gamma-beta subunit interface [polypeptide binding]; other site 1207075001736 alpha-beta subunit interface [polypeptide binding]; other site 1207075001737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075001738 Coenzyme A binding pocket [chemical binding]; other site 1207075001739 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1207075001740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075001741 Coenzyme A binding pocket [chemical binding]; other site 1207075001742 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1207075001743 alpha-gamma subunit interface [polypeptide binding]; other site 1207075001744 beta-gamma subunit interface [polypeptide binding]; other site 1207075001745 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1207075001746 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1207075001747 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1207075001748 Walker A/P-loop; other site 1207075001749 ATP binding site [chemical binding]; other site 1207075001750 Q-loop/lid; other site 1207075001751 ABC transporter signature motif; other site 1207075001752 Walker B; other site 1207075001753 D-loop; other site 1207075001754 H-loop/switch region; other site 1207075001755 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1207075001756 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1207075001757 Walker A/P-loop; other site 1207075001758 ATP binding site [chemical binding]; other site 1207075001759 Q-loop/lid; other site 1207075001760 ABC transporter signature motif; other site 1207075001761 Walker B; other site 1207075001762 D-loop; other site 1207075001763 H-loop/switch region; other site 1207075001764 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1207075001765 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1207075001766 TM-ABC transporter signature motif; other site 1207075001767 HEAT repeats; Region: HEAT_2; pfam13646 1207075001768 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1207075001769 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075001770 TM-ABC transporter signature motif; other site 1207075001771 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1207075001772 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1207075001773 putative ligand binding site [chemical binding]; other site 1207075001774 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1207075001775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1207075001776 ABC-ATPase subunit interface; other site 1207075001777 dimer interface [polypeptide binding]; other site 1207075001778 putative PBP binding regions; other site 1207075001779 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1207075001780 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1207075001781 putative ligand binding residues [chemical binding]; other site 1207075001782 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1207075001783 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1207075001784 Walker A/P-loop; other site 1207075001785 ATP binding site [chemical binding]; other site 1207075001786 Q-loop/lid; other site 1207075001787 ABC transporter signature motif; other site 1207075001788 Walker B; other site 1207075001789 D-loop; other site 1207075001790 H-loop/switch region; other site 1207075001791 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1207075001792 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1207075001793 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1207075001794 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1207075001795 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1207075001796 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1207075001797 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075001798 N-terminal plug; other site 1207075001799 ligand-binding site [chemical binding]; other site 1207075001800 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1207075001801 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1207075001802 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1207075001803 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1207075001804 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1207075001805 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1207075001806 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1207075001807 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1207075001808 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1207075001809 active site 1207075001810 putative homodimer interface [polypeptide binding]; other site 1207075001811 SAM binding site [chemical binding]; other site 1207075001812 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1207075001813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075001814 S-adenosylmethionine binding site [chemical binding]; other site 1207075001815 precorrin-3B synthase; Region: CobG; TIGR02435 1207075001816 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1207075001817 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1207075001818 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1207075001819 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1207075001820 active site 1207075001821 SAM binding site [chemical binding]; other site 1207075001822 homodimer interface [polypeptide binding]; other site 1207075001823 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1207075001824 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1207075001825 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1207075001826 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1207075001827 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1207075001828 active site 1207075001829 SAM binding site [chemical binding]; other site 1207075001830 homodimer interface [polypeptide binding]; other site 1207075001831 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1207075001832 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1207075001833 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1207075001834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075001835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075001836 dimer interface [polypeptide binding]; other site 1207075001837 phosphorylation site [posttranslational modification] 1207075001838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075001839 ATP binding site [chemical binding]; other site 1207075001840 Mg2+ binding site [ion binding]; other site 1207075001841 G-X-G motif; other site 1207075001842 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075001843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075001844 active site 1207075001845 phosphorylation site [posttranslational modification] 1207075001846 intermolecular recognition site; other site 1207075001847 dimerization interface [polypeptide binding]; other site 1207075001848 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075001849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075001850 active site 1207075001851 phosphorylation site [posttranslational modification] 1207075001852 intermolecular recognition site; other site 1207075001853 dimerization interface [polypeptide binding]; other site 1207075001854 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1207075001855 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1207075001856 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1207075001857 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1207075001858 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1207075001859 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1207075001860 purine monophosphate binding site [chemical binding]; other site 1207075001861 dimer interface [polypeptide binding]; other site 1207075001862 putative catalytic residues [active] 1207075001863 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1207075001864 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1207075001865 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1207075001866 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1207075001867 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1207075001868 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1207075001869 FMN binding site [chemical binding]; other site 1207075001870 active site 1207075001871 catalytic residues [active] 1207075001872 substrate binding site [chemical binding]; other site 1207075001873 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1207075001874 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1207075001875 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1207075001876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075001877 S-adenosylmethionine binding site [chemical binding]; other site 1207075001878 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1207075001879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075001880 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1207075001881 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1207075001882 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1207075001883 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1207075001884 carboxyltransferase (CT) interaction site; other site 1207075001885 biotinylation site [posttranslational modification]; other site 1207075001886 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1207075001887 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1207075001888 active site 1207075001889 trimer interface [polypeptide binding]; other site 1207075001890 dimer interface [polypeptide binding]; other site 1207075001891 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1207075001892 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1207075001893 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1207075001894 DsbD alpha interface [polypeptide binding]; other site 1207075001895 catalytic residues [active] 1207075001896 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075001897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001898 dimer interface [polypeptide binding]; other site 1207075001899 putative CheW interface [polypeptide binding]; other site 1207075001900 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1207075001901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075001902 active site 1207075001903 phosphorylation site [posttranslational modification] 1207075001904 intermolecular recognition site; other site 1207075001905 dimerization interface [polypeptide binding]; other site 1207075001906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075001907 metal binding site [ion binding]; metal-binding site 1207075001908 active site 1207075001909 I-site; other site 1207075001910 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1207075001911 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1207075001912 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1207075001913 nudix motif; other site 1207075001914 translation initiation factor Sui1; Validated; Region: PRK06824 1207075001915 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1207075001916 putative rRNA binding site [nucleotide binding]; other site 1207075001917 arginine decarboxylase; Provisional; Region: PRK05354 1207075001918 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1207075001919 dimer interface [polypeptide binding]; other site 1207075001920 active site 1207075001921 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1207075001922 catalytic residues [active] 1207075001923 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1207075001924 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1207075001925 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1207075001926 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1207075001927 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1207075001928 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1207075001929 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1207075001930 homodimer interface [polypeptide binding]; other site 1207075001931 chemical substrate binding site [chemical binding]; other site 1207075001932 oligomer interface [polypeptide binding]; other site 1207075001933 metal binding site [ion binding]; metal-binding site 1207075001934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075001935 S-adenosylmethionine binding site [chemical binding]; other site 1207075001936 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1207075001937 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1207075001938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075001939 heme pocket [chemical binding]; other site 1207075001940 putative active site [active] 1207075001941 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075001942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075001943 putative active site [active] 1207075001944 heme pocket [chemical binding]; other site 1207075001945 PAS domain; Region: PAS; smart00091 1207075001946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075001947 dimer interface [polypeptide binding]; other site 1207075001948 phosphorylation site [posttranslational modification] 1207075001949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075001950 ATP binding site [chemical binding]; other site 1207075001951 Mg2+ binding site [ion binding]; other site 1207075001952 G-X-G motif; other site 1207075001953 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1207075001954 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1207075001955 active site 2 [active] 1207075001956 active site 1 [active] 1207075001957 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1207075001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075001959 NAD(P) binding site [chemical binding]; other site 1207075001960 active site 1207075001961 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1207075001962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075001963 dimer interface [polypeptide binding]; other site 1207075001964 active site 1207075001965 Cache domain; Region: Cache_1; pfam02743 1207075001966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075001967 dimerization interface [polypeptide binding]; other site 1207075001968 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075001969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075001970 dimer interface [polypeptide binding]; other site 1207075001971 putative CheW interface [polypeptide binding]; other site 1207075001972 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1207075001973 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1207075001974 ATP binding site [chemical binding]; other site 1207075001975 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1207075001976 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1207075001977 DNA binding residues [nucleotide binding] 1207075001978 dimer interface [polypeptide binding]; other site 1207075001979 copper binding site [ion binding]; other site 1207075001980 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1207075001981 metal-binding site [ion binding] 1207075001982 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1207075001983 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1207075001984 metal-binding site [ion binding] 1207075001985 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1207075001986 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1207075001987 metal-binding site [ion binding] 1207075001988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075001989 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1207075001990 putative substrate translocation pore; other site 1207075001991 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1207075001992 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1207075001993 putative NAD(P) binding site [chemical binding]; other site 1207075001994 dimer interface [polypeptide binding]; other site 1207075001995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075001996 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075001997 putative effector binding pocket; other site 1207075001998 dimerization interface [polypeptide binding]; other site 1207075001999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075002000 putative DNA binding site [nucleotide binding]; other site 1207075002001 dimerization interface [polypeptide binding]; other site 1207075002002 putative Zn2+ binding site [ion binding]; other site 1207075002003 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1207075002004 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1207075002005 active site 1207075002006 purine riboside binding site [chemical binding]; other site 1207075002007 oxidase reductase; Provisional; Region: PTZ00273 1207075002008 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1207075002009 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1207075002010 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1207075002011 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1207075002012 putative ligand binding site [chemical binding]; other site 1207075002013 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1207075002014 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1207075002015 active site 1207075002016 putative substrate binding pocket [chemical binding]; other site 1207075002017 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1207075002018 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1207075002019 NADP binding site [chemical binding]; other site 1207075002020 homodimer interface [polypeptide binding]; other site 1207075002021 active site 1207075002022 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075002023 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1207075002024 TM-ABC transporter signature motif; other site 1207075002025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075002026 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1207075002027 TM-ABC transporter signature motif; other site 1207075002028 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1207075002029 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1207075002030 Walker A/P-loop; other site 1207075002031 ATP binding site [chemical binding]; other site 1207075002032 Q-loop/lid; other site 1207075002033 ABC transporter signature motif; other site 1207075002034 Walker B; other site 1207075002035 D-loop; other site 1207075002036 H-loop/switch region; other site 1207075002037 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1207075002038 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1207075002039 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1207075002040 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1207075002041 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1207075002042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075002043 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1207075002044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075002045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075002046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075002047 dimerization interface [polypeptide binding]; other site 1207075002048 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1207075002049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075002050 inhibitor-cofactor binding pocket; inhibition site 1207075002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075002052 catalytic residue [active] 1207075002053 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1207075002054 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1207075002055 tetrameric interface [polypeptide binding]; other site 1207075002056 NAD binding site [chemical binding]; other site 1207075002057 catalytic residues [active] 1207075002058 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1207075002059 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1207075002060 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1207075002061 Family description; Region: UvrD_C_2; pfam13538 1207075002062 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1207075002063 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1207075002064 AAA domain; Region: AAA_30; pfam13604 1207075002065 Family description; Region: UvrD_C_2; pfam13538 1207075002066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075002067 S-adenosylmethionine binding site [chemical binding]; other site 1207075002068 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1207075002069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075002070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075002071 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075002072 dimerization interface [polypeptide binding]; other site 1207075002073 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1207075002074 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1207075002075 tetrameric interface [polypeptide binding]; other site 1207075002076 NAD binding site [chemical binding]; other site 1207075002077 catalytic residues [active] 1207075002078 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1207075002079 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1207075002080 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1207075002081 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1207075002082 Helix-Turn-Helix DNA binding domain of MerR2-like transcription regulators; Region: HTH_MerR2; cd04769 1207075002083 DNA binding residues [nucleotide binding] 1207075002084 putative dimer interface [polypeptide binding]; other site 1207075002085 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1207075002086 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075002087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075002088 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1207075002089 putative dimerization interface [polypeptide binding]; other site 1207075002090 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1207075002091 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1207075002092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075002093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075002094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075002095 dimerization interface [polypeptide binding]; other site 1207075002096 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1207075002097 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1207075002098 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075002099 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1207075002100 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1207075002101 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1207075002102 active site 1207075002103 putative substrate binding pocket [chemical binding]; other site 1207075002104 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1207075002105 dimer interface [polypeptide binding]; other site 1207075002106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075002107 ligand binding site [chemical binding]; other site 1207075002108 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075002109 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075002110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075002111 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1207075002112 FAD binding domain; Region: FAD_binding_4; pfam01565 1207075002113 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1207075002114 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1207075002115 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 1207075002116 putative N- and C-terminal domain interface [polypeptide binding]; other site 1207075002117 putative active site [active] 1207075002118 MgATP binding site [chemical binding]; other site 1207075002119 catalytic site [active] 1207075002120 metal binding site [ion binding]; metal-binding site 1207075002121 putative carbohydrate binding site [chemical binding]; other site 1207075002122 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1207075002123 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075002124 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075002125 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1207075002126 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1207075002127 oligomeric interface; other site 1207075002128 putative active site [active] 1207075002129 homodimer interface [polypeptide binding]; other site 1207075002130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075002131 dimerization interface [polypeptide binding]; other site 1207075002132 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075002133 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075002134 dimer interface [polypeptide binding]; other site 1207075002135 putative CheW interface [polypeptide binding]; other site 1207075002136 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1207075002137 catalytic core [active] 1207075002138 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1207075002139 active site 1207075002140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1207075002141 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1207075002142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075002143 non-specific DNA binding site [nucleotide binding]; other site 1207075002144 salt bridge; other site 1207075002145 sequence-specific DNA binding site [nucleotide binding]; other site 1207075002146 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1207075002147 catalytic triad [active] 1207075002148 conserved cis-peptide bond; other site 1207075002149 hypothetical protein; Validated; Region: PRK09039 1207075002150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1207075002151 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 1207075002152 Predicted transcriptional regulator [Transcription]; Region: COG2378 1207075002153 WYL domain; Region: WYL; pfam13280 1207075002154 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 1207075002155 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1207075002156 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1207075002157 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1207075002158 WYL domain; Region: WYL; pfam13280 1207075002159 HTH domain; Region: HTH_11; cl17392 1207075002160 Predicted transcriptional regulator [Transcription]; Region: COG2378 1207075002161 WYL domain; Region: WYL; pfam13280 1207075002162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075002163 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1207075002164 Walker A motif; other site 1207075002165 ATP binding site [chemical binding]; other site 1207075002166 Walker B motif; other site 1207075002167 arginine finger; other site 1207075002168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075002169 Walker A motif; other site 1207075002170 ATP binding site [chemical binding]; other site 1207075002171 Walker B motif; other site 1207075002172 arginine finger; other site 1207075002173 WYL domain; Region: WYL; pfam13280 1207075002174 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1207075002175 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1207075002176 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1207075002177 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1207075002178 Dynamin family; Region: Dynamin_N; pfam00350 1207075002179 G1 box; other site 1207075002180 GTP/Mg2+ binding site [chemical binding]; other site 1207075002181 G2 box; other site 1207075002182 Switch I region; other site 1207075002183 G3 box; other site 1207075002184 Switch II region; other site 1207075002185 G4 box; other site 1207075002186 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1207075002187 G1 box; other site 1207075002188 GTP/Mg2+ binding site [chemical binding]; other site 1207075002189 G2 box; other site 1207075002190 Switch I region; other site 1207075002191 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1207075002192 G3 box; other site 1207075002193 Switch II region; other site 1207075002194 G4 box; other site 1207075002195 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1207075002196 G1 box; other site 1207075002197 GTP/Mg2+ binding site [chemical binding]; other site 1207075002198 G2 box; other site 1207075002199 Switch I region; other site 1207075002200 G3 box; other site 1207075002201 Switch II region; other site 1207075002202 G4 box; other site 1207075002203 Protein of unknown function (DUF726); Region: DUF726; pfam05277 1207075002204 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1207075002205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075002206 ATP binding site [chemical binding]; other site 1207075002207 putative Mg++ binding site [ion binding]; other site 1207075002208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075002209 nucleotide binding region [chemical binding]; other site 1207075002210 ATP-binding site [chemical binding]; other site 1207075002211 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1207075002212 Protein of unknown function DUF262; Region: DUF262; pfam03235 1207075002213 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1207075002214 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1207075002215 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1207075002216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075002217 ATP binding site [chemical binding]; other site 1207075002218 putative Mg++ binding site [ion binding]; other site 1207075002219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075002220 nucleotide binding region [chemical binding]; other site 1207075002221 ATP-binding site [chemical binding]; other site 1207075002222 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1207075002223 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1207075002224 Family description; Region: UvrD_C_2; pfam13538 1207075002225 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1207075002226 Integrase; Region: Integrase_1; pfam12835 1207075002227 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1207075002228 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1207075002229 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075002230 ligand binding site [chemical binding]; other site 1207075002231 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1207075002232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075002233 ATP binding site [chemical binding]; other site 1207075002234 putative Mg++ binding site [ion binding]; other site 1207075002235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075002236 nucleotide binding region [chemical binding]; other site 1207075002237 ATP-binding site [chemical binding]; other site 1207075002238 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 1207075002239 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1207075002240 integrase; Provisional; Region: PRK09692 1207075002241 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1207075002242 active site 1207075002243 Int/Topo IB signature motif; other site 1207075002244 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1207075002245 FAD binding domain; Region: FAD_binding_4; pfam01565 1207075002246 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1207075002247 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1207075002248 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1207075002249 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1207075002250 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1207075002251 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1207075002252 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1207075002253 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1207075002254 Cysteine-rich domain; Region: CCG; pfam02754 1207075002255 Cysteine-rich domain; Region: CCG; pfam02754 1207075002256 glycolate transporter; Provisional; Region: PRK09695 1207075002257 L-lactate permease; Region: Lactate_perm; cl00701 1207075002258 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075002259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075002260 DNA-binding site [nucleotide binding]; DNA binding site 1207075002261 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1207075002262 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1207075002263 SmpB-tmRNA interface; other site 1207075002264 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1207075002265 Na2 binding site [ion binding]; other site 1207075002266 putative substrate binding site 1 [chemical binding]; other site 1207075002267 Na binding site 1 [ion binding]; other site 1207075002268 putative substrate binding site 2 [chemical binding]; other site 1207075002269 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1207075002270 putative coenzyme Q binding site [chemical binding]; other site 1207075002271 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1207075002272 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1207075002273 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1207075002274 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1207075002275 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1207075002276 metal binding site 2 [ion binding]; metal-binding site 1207075002277 putative DNA binding helix; other site 1207075002278 metal binding site 1 [ion binding]; metal-binding site 1207075002279 dimer interface [polypeptide binding]; other site 1207075002280 structural Zn2+ binding site [ion binding]; other site 1207075002281 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1207075002282 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1207075002283 Walker A/P-loop; other site 1207075002284 ATP binding site [chemical binding]; other site 1207075002285 Q-loop/lid; other site 1207075002286 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1207075002287 Q-loop/lid; other site 1207075002288 ABC transporter signature motif; other site 1207075002289 Walker B; other site 1207075002290 D-loop; other site 1207075002291 H-loop/switch region; other site 1207075002292 GrpE; Region: GrpE; pfam01025 1207075002293 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1207075002294 dimer interface [polypeptide binding]; other site 1207075002295 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1207075002296 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1207075002297 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1207075002298 nucleotide binding site [chemical binding]; other site 1207075002299 chaperone protein DnaJ; Provisional; Region: PRK10767 1207075002300 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1207075002301 HSP70 interaction site [polypeptide binding]; other site 1207075002302 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1207075002303 substrate binding site [polypeptide binding]; other site 1207075002304 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1207075002305 Zn binding sites [ion binding]; other site 1207075002306 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1207075002307 dimer interface [polypeptide binding]; other site 1207075002308 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1207075002309 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1207075002310 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1207075002311 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1207075002312 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1207075002313 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1207075002314 catalytic site [active] 1207075002315 subunit interface [polypeptide binding]; other site 1207075002316 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1207075002317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075002318 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1207075002319 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1207075002320 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075002321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1207075002322 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1207075002323 IMP binding site; other site 1207075002324 dimer interface [polypeptide binding]; other site 1207075002325 interdomain contacts; other site 1207075002326 partial ornithine binding site; other site 1207075002327 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1207075002328 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1207075002329 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1207075002330 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1207075002331 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1207075002332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075002333 S-adenosylmethionine binding site [chemical binding]; other site 1207075002334 FtsH Extracellular; Region: FtsH_ext; pfam06480 1207075002335 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1207075002336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075002337 Walker A motif; other site 1207075002338 ATP binding site [chemical binding]; other site 1207075002339 Walker B motif; other site 1207075002340 arginine finger; other site 1207075002341 Peptidase family M41; Region: Peptidase_M41; pfam01434 1207075002342 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1207075002343 dihydropteroate synthase; Region: DHPS; TIGR01496 1207075002344 substrate binding pocket [chemical binding]; other site 1207075002345 dimer interface [polypeptide binding]; other site 1207075002346 inhibitor binding site; inhibition site 1207075002347 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1207075002348 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1207075002349 active site 1207075002350 substrate binding site [chemical binding]; other site 1207075002351 metal binding site [ion binding]; metal-binding site 1207075002352 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1207075002353 triosephosphate isomerase; Provisional; Region: PRK14567 1207075002354 substrate binding site [chemical binding]; other site 1207075002355 dimer interface [polypeptide binding]; other site 1207075002356 catalytic triad [active] 1207075002357 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1207075002358 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1207075002359 Sm and related proteins; Region: Sm_like; cl00259 1207075002360 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1207075002361 putative oligomer interface [polypeptide binding]; other site 1207075002362 putative RNA binding site [nucleotide binding]; other site 1207075002363 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1207075002364 NusA N-terminal domain; Region: NusA_N; pfam08529 1207075002365 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1207075002366 RNA binding site [nucleotide binding]; other site 1207075002367 homodimer interface [polypeptide binding]; other site 1207075002368 NusA-like KH domain; Region: KH_5; pfam13184 1207075002369 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1207075002370 G-X-X-G motif; other site 1207075002371 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1207075002372 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1207075002373 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1207075002374 translation initiation factor IF-2; Region: IF-2; TIGR00487 1207075002375 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1207075002376 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1207075002377 G1 box; other site 1207075002378 putative GEF interaction site [polypeptide binding]; other site 1207075002379 GTP/Mg2+ binding site [chemical binding]; other site 1207075002380 Switch I region; other site 1207075002381 G2 box; other site 1207075002382 G3 box; other site 1207075002383 Switch II region; other site 1207075002384 G4 box; other site 1207075002385 G5 box; other site 1207075002386 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1207075002387 Translation-initiation factor 2; Region: IF-2; pfam11987 1207075002388 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1207075002389 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1207075002390 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1207075002391 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1207075002392 RNA binding site [nucleotide binding]; other site 1207075002393 active site 1207075002394 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1207075002395 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1207075002396 16S/18S rRNA binding site [nucleotide binding]; other site 1207075002397 S13e-L30e interaction site [polypeptide binding]; other site 1207075002398 25S rRNA binding site [nucleotide binding]; other site 1207075002399 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1207075002400 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1207075002401 RNase E interface [polypeptide binding]; other site 1207075002402 trimer interface [polypeptide binding]; other site 1207075002403 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1207075002404 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1207075002405 RNase E interface [polypeptide binding]; other site 1207075002406 trimer interface [polypeptide binding]; other site 1207075002407 active site 1207075002408 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1207075002409 putative nucleic acid binding region [nucleotide binding]; other site 1207075002410 G-X-X-G motif; other site 1207075002411 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1207075002412 RNA binding site [nucleotide binding]; other site 1207075002413 domain interface; other site 1207075002414 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1207075002415 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1207075002416 dimerization interface [polypeptide binding]; other site 1207075002417 active site 1207075002418 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1207075002419 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1207075002420 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1207075002421 amidase catalytic site [active] 1207075002422 Zn binding residues [ion binding]; other site 1207075002423 substrate binding site [chemical binding]; other site 1207075002424 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1207075002425 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1207075002426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075002427 dimerization interface [polypeptide binding]; other site 1207075002428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075002429 dimer interface [polypeptide binding]; other site 1207075002430 putative CheW interface [polypeptide binding]; other site 1207075002431 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1207075002432 active site 1207075002433 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1207075002434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1207075002435 DNA binding site [nucleotide binding] 1207075002436 domain linker motif; other site 1207075002437 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1207075002438 dimerization interface [polypeptide binding]; other site 1207075002439 ligand binding site [chemical binding]; other site 1207075002440 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1207075002441 active site 1207075002442 phosphorylation site [posttranslational modification] 1207075002443 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1207075002444 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1207075002445 regulatory protein interface [polypeptide binding]; other site 1207075002446 active site 1207075002447 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1207075002448 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1207075002449 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1207075002450 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1207075002451 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1207075002452 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1207075002453 putative substrate binding site [chemical binding]; other site 1207075002454 putative ATP binding site [chemical binding]; other site 1207075002455 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1207075002456 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1207075002457 active site 1207075002458 P-loop; other site 1207075002459 phosphorylation site [posttranslational modification] 1207075002460 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1207075002461 active site 1207075002462 P-loop; other site 1207075002463 phosphorylation site [posttranslational modification] 1207075002464 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1207075002465 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1207075002466 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1207075002467 putative active site [active] 1207075002468 putative metal binding site [ion binding]; other site 1207075002469 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1207075002470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1207075002471 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1207075002472 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1207075002473 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1207075002474 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1207075002475 Flavodoxin; Region: Flavodoxin_1; pfam00258 1207075002476 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1207075002477 FAD binding pocket [chemical binding]; other site 1207075002478 FAD binding motif [chemical binding]; other site 1207075002479 catalytic residues [active] 1207075002480 NAD binding pocket [chemical binding]; other site 1207075002481 phosphate binding motif [ion binding]; other site 1207075002482 beta-alpha-beta structure motif; other site 1207075002483 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1207075002484 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075002485 N-terminal plug; other site 1207075002486 ligand-binding site [chemical binding]; other site 1207075002487 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1207075002488 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1207075002489 Sel1-like repeats; Region: SEL1; smart00671 1207075002490 Sel1 repeat; Region: Sel1; cl02723 1207075002491 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1207075002492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1207075002493 dimer interface [polypeptide binding]; other site 1207075002494 active site 1207075002495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1207075002496 catalytic residues [active] 1207075002497 substrate binding site [chemical binding]; other site 1207075002498 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1207075002499 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1207075002500 Walker A/P-loop; other site 1207075002501 ATP binding site [chemical binding]; other site 1207075002502 Q-loop/lid; other site 1207075002503 ABC transporter signature motif; other site 1207075002504 Walker B; other site 1207075002505 D-loop; other site 1207075002506 H-loop/switch region; other site 1207075002507 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1207075002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075002509 dimer interface [polypeptide binding]; other site 1207075002510 conserved gate region; other site 1207075002511 ABC-ATPase subunit interface; other site 1207075002512 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1207075002513 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1207075002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075002515 ABC-ATPase subunit interface; other site 1207075002516 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1207075002517 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1207075002518 G1 box; other site 1207075002519 putative GEF interaction site [polypeptide binding]; other site 1207075002520 GTP/Mg2+ binding site [chemical binding]; other site 1207075002521 Switch I region; other site 1207075002522 G2 box; other site 1207075002523 G3 box; other site 1207075002524 Switch II region; other site 1207075002525 G4 box; other site 1207075002526 G5 box; other site 1207075002527 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1207075002528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075002529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075002530 putative substrate translocation pore; other site 1207075002531 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075002532 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075002533 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1207075002534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1207075002535 Walker A/P-loop; other site 1207075002536 ATP binding site [chemical binding]; other site 1207075002537 Q-loop/lid; other site 1207075002538 ABC transporter signature motif; other site 1207075002539 Walker B; other site 1207075002540 D-loop; other site 1207075002541 H-loop/switch region; other site 1207075002542 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1207075002543 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1207075002544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1207075002545 Walker A/P-loop; other site 1207075002546 ATP binding site [chemical binding]; other site 1207075002547 Q-loop/lid; other site 1207075002548 ABC transporter signature motif; other site 1207075002549 Walker B; other site 1207075002550 D-loop; other site 1207075002551 H-loop/switch region; other site 1207075002552 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1207075002553 dipeptide transporter; Provisional; Region: PRK10913 1207075002554 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1207075002555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075002556 dimer interface [polypeptide binding]; other site 1207075002557 conserved gate region; other site 1207075002558 putative PBP binding loops; other site 1207075002559 ABC-ATPase subunit interface; other site 1207075002560 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1207075002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075002562 dimer interface [polypeptide binding]; other site 1207075002563 conserved gate region; other site 1207075002564 putative PBP binding loops; other site 1207075002565 ABC-ATPase subunit interface; other site 1207075002566 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1207075002567 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1207075002568 peptide binding site [polypeptide binding]; other site 1207075002569 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075002570 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1207075002571 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1207075002572 peptide binding site [polypeptide binding]; other site 1207075002573 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1207075002574 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1207075002575 peptide binding site [polypeptide binding]; other site 1207075002576 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1207075002577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075002578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075002579 ATP binding site [chemical binding]; other site 1207075002580 G-X-G motif; other site 1207075002581 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1207075002582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075002583 active site 1207075002584 phosphorylation site [posttranslational modification] 1207075002585 intermolecular recognition site; other site 1207075002586 dimerization interface [polypeptide binding]; other site 1207075002587 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075002588 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1207075002589 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1207075002590 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1207075002591 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075002592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075002593 DNA-binding site [nucleotide binding]; DNA binding site 1207075002594 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1207075002595 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1207075002596 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1207075002597 putative active site [active] 1207075002598 catalytic residue [active] 1207075002599 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1207075002600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075002601 NAD(P) binding site [chemical binding]; other site 1207075002602 catalytic residues [active] 1207075002603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075002604 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075002605 putative substrate translocation pore; other site 1207075002606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075002607 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1207075002608 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1207075002609 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1207075002610 Predicted permeases [General function prediction only]; Region: COG0679 1207075002611 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1207075002612 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1207075002613 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1207075002614 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1207075002615 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1207075002616 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1207075002617 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1207075002618 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1207075002619 GatB domain; Region: GatB_Yqey; smart00845 1207075002620 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1207075002621 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1207075002622 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1207075002623 rod shape-determining protein MreB; Provisional; Region: PRK13927 1207075002624 MreB and similar proteins; Region: MreB_like; cd10225 1207075002625 nucleotide binding site [chemical binding]; other site 1207075002626 Mg binding site [ion binding]; other site 1207075002627 putative protofilament interaction site [polypeptide binding]; other site 1207075002628 RodZ interaction site [polypeptide binding]; other site 1207075002629 rod shape-determining protein MreC; Provisional; Region: PRK13922 1207075002630 rod shape-determining protein MreC; Region: MreC; pfam04085 1207075002631 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1207075002632 Maf-like protein; Region: Maf; pfam02545 1207075002633 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1207075002634 active site 1207075002635 dimer interface [polypeptide binding]; other site 1207075002636 ribonuclease G; Provisional; Region: PRK11712 1207075002637 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1207075002638 homodimer interface [polypeptide binding]; other site 1207075002639 oligonucleotide binding site [chemical binding]; other site 1207075002640 TIGR02099 family protein; Region: TIGR02099 1207075002641 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1207075002642 nitrilase; Region: PLN02798 1207075002643 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1207075002644 putative active site [active] 1207075002645 catalytic triad [active] 1207075002646 dimer interface [polypeptide binding]; other site 1207075002647 protease TldD; Provisional; Region: tldD; PRK10735 1207075002648 hypothetical protein; Provisional; Region: PRK05255 1207075002649 peptidase PmbA; Provisional; Region: PRK11040 1207075002650 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1207075002651 dimerization domain swap beta strand [polypeptide binding]; other site 1207075002652 regulatory protein interface [polypeptide binding]; other site 1207075002653 active site 1207075002654 regulatory phosphorylation site [posttranslational modification]; other site 1207075002655 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1207075002656 AAA domain; Region: AAA_18; pfam13238 1207075002657 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1207075002658 active site 1207075002659 phosphorylation site [posttranslational modification] 1207075002660 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1207075002661 30S subunit binding site; other site 1207075002662 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1207075002663 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1207075002664 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1207075002665 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1207075002666 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1207075002667 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1207075002668 Walker A/P-loop; other site 1207075002669 ATP binding site [chemical binding]; other site 1207075002670 Q-loop/lid; other site 1207075002671 ABC transporter signature motif; other site 1207075002672 Walker B; other site 1207075002673 D-loop; other site 1207075002674 H-loop/switch region; other site 1207075002675 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1207075002676 OstA-like protein; Region: OstA; pfam03968 1207075002677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1207075002678 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1207075002679 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1207075002680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075002681 active site 1207075002682 motif I; other site 1207075002683 motif II; other site 1207075002684 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1207075002685 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1207075002686 putative active site [active] 1207075002687 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1207075002688 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1207075002689 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1207075002690 Walker A/P-loop; other site 1207075002691 ATP binding site [chemical binding]; other site 1207075002692 Q-loop/lid; other site 1207075002693 ABC transporter signature motif; other site 1207075002694 Walker B; other site 1207075002695 D-loop; other site 1207075002696 H-loop/switch region; other site 1207075002697 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1207075002698 Permease; Region: Permease; cl00510 1207075002699 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1207075002700 mce related protein; Region: MCE; pfam02470 1207075002701 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1207075002702 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1207075002703 anti sigma factor interaction site; other site 1207075002704 regulatory phosphorylation site [posttranslational modification]; other site 1207075002705 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1207075002706 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1207075002707 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1207075002708 hinge; other site 1207075002709 active site 1207075002710 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1207075002711 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1207075002712 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1207075002713 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1207075002714 NAD binding site [chemical binding]; other site 1207075002715 dimerization interface [polypeptide binding]; other site 1207075002716 product binding site; other site 1207075002717 substrate binding site [chemical binding]; other site 1207075002718 zinc binding site [ion binding]; other site 1207075002719 catalytic residues [active] 1207075002720 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1207075002721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075002722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075002723 homodimer interface [polypeptide binding]; other site 1207075002724 catalytic residue [active] 1207075002725 serine endoprotease; Provisional; Region: PRK10898 1207075002726 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1207075002727 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1207075002728 protein binding site [polypeptide binding]; other site 1207075002729 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1207075002730 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1207075002731 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1207075002732 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1207075002733 Active Sites [active] 1207075002734 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1207075002735 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1207075002736 CysD dimerization site [polypeptide binding]; other site 1207075002737 G1 box; other site 1207075002738 putative GEF interaction site [polypeptide binding]; other site 1207075002739 GTP/Mg2+ binding site [chemical binding]; other site 1207075002740 Switch I region; other site 1207075002741 G2 box; other site 1207075002742 G3 box; other site 1207075002743 Switch II region; other site 1207075002744 G4 box; other site 1207075002745 G5 box; other site 1207075002746 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1207075002747 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1207075002748 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1207075002749 ligand-binding site [chemical binding]; other site 1207075002750 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075002751 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1207075002752 putative acyl-acceptor binding pocket; other site 1207075002753 phosphate acetyltransferase; Reviewed; Region: PRK05632 1207075002754 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075002755 DRTGG domain; Region: DRTGG; pfam07085 1207075002756 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1207075002757 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1207075002758 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075002759 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1207075002760 catalytic residues [active] 1207075002761 dimer interface [polypeptide binding]; other site 1207075002762 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075002763 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1207075002764 putative active site [active] 1207075002765 putative FMN binding site [chemical binding]; other site 1207075002766 putative substrate binding site [chemical binding]; other site 1207075002767 putative catalytic residue [active] 1207075002768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075002769 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1207075002770 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1207075002771 thioredoxin reductase; Provisional; Region: PRK10262 1207075002772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075002773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075002774 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1207075002775 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075002776 inhibitor-cofactor binding pocket; inhibition site 1207075002777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075002778 catalytic residue [active] 1207075002779 HopJ type III effector protein; Region: HopJ; pfam08888 1207075002780 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 1207075002781 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1207075002782 homooctamer interface [polypeptide binding]; other site 1207075002783 active site 1207075002784 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1207075002785 homodecamer interface [polypeptide binding]; other site 1207075002786 GTP cyclohydrolase I; Provisional; Region: PLN03044 1207075002787 active site 1207075002788 putative catalytic site residues [active] 1207075002789 zinc binding site [ion binding]; other site 1207075002790 GTP-CH-I/GFRP interaction surface; other site 1207075002791 dihydromonapterin reductase; Provisional; Region: PRK06483 1207075002792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075002793 NAD(P) binding site [chemical binding]; other site 1207075002794 active site 1207075002795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1207075002796 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1207075002797 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1207075002798 DNA binding residues [nucleotide binding] 1207075002799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075002800 PAS domain; Region: PAS_9; pfam13426 1207075002801 putative active site [active] 1207075002802 heme pocket [chemical binding]; other site 1207075002803 flavodoxin; Provisional; Region: PRK05723 1207075002804 aldolase II superfamily protein; Provisional; Region: PRK07044 1207075002805 intersubunit interface [polypeptide binding]; other site 1207075002806 active site 1207075002807 Zn2+ binding site [ion binding]; other site 1207075002808 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075002809 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1207075002810 homodimer interface [polypeptide binding]; other site 1207075002811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1207075002812 NAD binding site [chemical binding]; other site 1207075002813 active site 1207075002814 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1207075002815 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1207075002816 amidase catalytic site [active] 1207075002817 Zn binding residues [ion binding]; other site 1207075002818 substrate binding site [chemical binding]; other site 1207075002819 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075002820 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075002821 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1207075002822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075002823 DNA binding residues [nucleotide binding] 1207075002824 dimerization interface [polypeptide binding]; other site 1207075002825 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1207075002826 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1207075002827 Bacterial transcriptional regulator; Region: IclR; pfam01614 1207075002828 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1207075002829 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1207075002830 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1207075002831 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1207075002832 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1207075002833 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1207075002834 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1207075002835 dimer interface [polypeptide binding]; other site 1207075002836 N-terminal domain interface [polypeptide binding]; other site 1207075002837 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1207075002838 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1207075002839 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1207075002840 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1207075002841 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1207075002842 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1207075002843 NAD binding site [chemical binding]; other site 1207075002844 Phe binding site; other site 1207075002845 YebG protein; Region: YebG; pfam07130 1207075002846 Predicted membrane protein [Function unknown]; Region: COG3223 1207075002847 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1207075002848 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1207075002849 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1207075002850 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1207075002851 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075002852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075002853 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075002854 dimerization interface [polypeptide binding]; other site 1207075002855 substrate binding pocket [chemical binding]; other site 1207075002856 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1207075002857 30S subunit binding site; other site 1207075002858 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1207075002859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075002860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075002861 DNA binding residues [nucleotide binding] 1207075002862 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1207075002863 FecR protein; Region: FecR; pfam04773 1207075002864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075002865 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075002866 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075002867 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075002868 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1207075002869 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075002870 N-terminal plug; other site 1207075002871 ligand-binding site [chemical binding]; other site 1207075002872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075002873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075002874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075002875 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075002876 EamA-like transporter family; Region: EamA; pfam00892 1207075002877 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 1207075002878 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1207075002879 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1207075002880 dimerization interface [polypeptide binding]; other site 1207075002881 ligand binding site [chemical binding]; other site 1207075002882 NADP binding site [chemical binding]; other site 1207075002883 catalytic site [active] 1207075002884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1207075002885 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1207075002886 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075002887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075002888 active site 1207075002889 phosphorylation site [posttranslational modification] 1207075002890 intermolecular recognition site; other site 1207075002891 dimerization interface [polypeptide binding]; other site 1207075002892 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1207075002893 GAF domain; Region: GAF; pfam01590 1207075002894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075002895 Walker A motif; other site 1207075002896 ATP binding site [chemical binding]; other site 1207075002897 Walker B motif; other site 1207075002898 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1207075002899 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1207075002900 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1207075002901 heme-binding site [chemical binding]; other site 1207075002902 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1207075002903 FAD binding pocket [chemical binding]; other site 1207075002904 FAD binding motif [chemical binding]; other site 1207075002905 phosphate binding motif [ion binding]; other site 1207075002906 beta-alpha-beta structure motif; other site 1207075002907 NAD binding pocket [chemical binding]; other site 1207075002908 Heme binding pocket [chemical binding]; other site 1207075002909 disulfide bond formation protein B; Provisional; Region: PRK02110 1207075002910 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1207075002911 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1207075002912 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1207075002913 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1207075002914 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1207075002915 D-pathway; other site 1207075002916 Putative ubiquinol binding site [chemical binding]; other site 1207075002917 Low-spin heme (heme b) binding site [chemical binding]; other site 1207075002918 Putative water exit pathway; other site 1207075002919 Binuclear center (heme o3/CuB) [ion binding]; other site 1207075002920 K-pathway; other site 1207075002921 Putative proton exit pathway; other site 1207075002922 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1207075002923 Subunit I/III interface [polypeptide binding]; other site 1207075002924 Subunit III/IV interface [polypeptide binding]; other site 1207075002925 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1207075002926 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1207075002927 UbiA prenyltransferase family; Region: UbiA; pfam01040 1207075002928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075002929 non-specific DNA binding site [nucleotide binding]; other site 1207075002930 salt bridge; other site 1207075002931 sequence-specific DNA binding site [nucleotide binding]; other site 1207075002932 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1207075002933 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075002934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075002935 DNA-binding site [nucleotide binding]; DNA binding site 1207075002936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075002937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075002938 homodimer interface [polypeptide binding]; other site 1207075002939 catalytic residue [active] 1207075002940 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1207075002941 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1207075002942 homotrimer interaction site [polypeptide binding]; other site 1207075002943 putative active site [active] 1207075002944 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1207075002945 glutathione S-transferase; Provisional; Region: PRK15113 1207075002946 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1207075002947 C-terminal domain interface [polypeptide binding]; other site 1207075002948 GSH binding site (G-site) [chemical binding]; other site 1207075002949 dimer interface [polypeptide binding]; other site 1207075002950 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1207075002951 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075002952 N-terminal domain interface [polypeptide binding]; other site 1207075002953 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1207075002954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075002955 FeS/SAM binding site; other site 1207075002956 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1207075002957 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1207075002958 homodimer interface [polypeptide binding]; other site 1207075002959 substrate-cofactor binding pocket; other site 1207075002960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075002961 catalytic residue [active] 1207075002962 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1207075002963 active site 1207075002964 iron coordination sites [ion binding]; other site 1207075002965 substrate binding pocket [chemical binding]; other site 1207075002966 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1207075002967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1207075002968 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075002969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075002970 DNA-binding site [nucleotide binding]; DNA binding site 1207075002971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075002972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075002973 homodimer interface [polypeptide binding]; other site 1207075002974 catalytic residue [active] 1207075002975 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075002976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075002977 dimer interface [polypeptide binding]; other site 1207075002978 conserved gate region; other site 1207075002979 putative PBP binding loops; other site 1207075002980 ABC-ATPase subunit interface; other site 1207075002981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075002982 dimer interface [polypeptide binding]; other site 1207075002983 conserved gate region; other site 1207075002984 putative PBP binding loops; other site 1207075002985 ABC-ATPase subunit interface; other site 1207075002986 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075002987 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075002988 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075002989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075002990 Walker A/P-loop; other site 1207075002991 ATP binding site [chemical binding]; other site 1207075002992 Q-loop/lid; other site 1207075002993 ABC transporter signature motif; other site 1207075002994 Walker B; other site 1207075002995 D-loop; other site 1207075002996 H-loop/switch region; other site 1207075002997 TOBE domain; Region: TOBE_2; pfam08402 1207075002998 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075002999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075003000 putative DNA binding site [nucleotide binding]; other site 1207075003001 putative Zn2+ binding site [ion binding]; other site 1207075003002 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075003003 dimerization interface [polypeptide binding]; other site 1207075003004 substrate binding pocket [chemical binding]; other site 1207075003005 hypothetical protein; Provisional; Region: PRK07524 1207075003006 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1207075003007 PYR/PP interface [polypeptide binding]; other site 1207075003008 dimer interface [polypeptide binding]; other site 1207075003009 TPP binding site [chemical binding]; other site 1207075003010 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1207075003011 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1207075003012 TPP-binding site [chemical binding]; other site 1207075003013 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1207075003014 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1207075003015 active site 1207075003016 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1207075003017 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1207075003018 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1207075003019 aldolase II superfamily protein; Provisional; Region: PRK07044 1207075003020 intersubunit interface [polypeptide binding]; other site 1207075003021 active site 1207075003022 Zn2+ binding site [ion binding]; other site 1207075003023 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1207075003024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075003025 dimer interface [polypeptide binding]; other site 1207075003026 phosphorylation site [posttranslational modification] 1207075003027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075003028 ATP binding site [chemical binding]; other site 1207075003029 Mg2+ binding site [ion binding]; other site 1207075003030 G-X-G motif; other site 1207075003031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075003032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075003033 active site 1207075003034 phosphorylation site [posttranslational modification] 1207075003035 intermolecular recognition site; other site 1207075003036 dimerization interface [polypeptide binding]; other site 1207075003037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075003038 DNA binding site [nucleotide binding] 1207075003039 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1207075003040 SelR domain; Region: SelR; pfam01641 1207075003041 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1207075003042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075003043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075003044 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1207075003045 putative effector binding pocket; other site 1207075003046 putative dimerization interface [polypeptide binding]; other site 1207075003047 acetylornithine aminotransferase; Provisional; Region: PRK02627 1207075003048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075003049 inhibitor-cofactor binding pocket; inhibition site 1207075003050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075003051 catalytic residue [active] 1207075003052 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1207075003053 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1207075003054 AAA domain; Region: AAA_17; pfam13207 1207075003055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1207075003056 metal binding site [ion binding]; metal-binding site 1207075003057 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1207075003058 putative active site [active] 1207075003059 putative metal binding site [ion binding]; other site 1207075003060 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1207075003061 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1207075003062 NADP binding site [chemical binding]; other site 1207075003063 dimer interface [polypeptide binding]; other site 1207075003064 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1207075003065 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1207075003066 substrate binding pocket [chemical binding]; other site 1207075003067 active site 1207075003068 iron coordination sites [ion binding]; other site 1207075003069 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1207075003070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075003071 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075003072 putative substrate translocation pore; other site 1207075003073 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1207075003074 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1207075003075 catalytic residues [active] 1207075003076 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1207075003077 iron-sulfur cluster [ion binding]; other site 1207075003078 [2Fe-2S] cluster binding site [ion binding]; other site 1207075003079 Predicted membrane protein [Function unknown]; Region: COG2855 1207075003080 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075003081 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075003082 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1207075003083 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075003084 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075003085 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075003086 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1207075003087 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1207075003088 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1207075003089 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1207075003090 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1207075003091 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075003092 active site 1207075003093 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1207075003094 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1207075003095 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1207075003096 dimer interface [polypeptide binding]; other site 1207075003097 acyl-activating enzyme (AAE) consensus motif; other site 1207075003098 putative active site [active] 1207075003099 AMP binding site [chemical binding]; other site 1207075003100 putative CoA binding site [chemical binding]; other site 1207075003101 Ion channel; Region: Ion_trans_2; pfam07885 1207075003102 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1207075003103 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1207075003104 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1207075003105 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075003106 catalytic loop [active] 1207075003107 iron binding site [ion binding]; other site 1207075003108 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1207075003109 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1207075003110 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1207075003111 [4Fe-4S] binding site [ion binding]; other site 1207075003112 molybdopterin cofactor binding site; other site 1207075003113 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1207075003114 molybdopterin cofactor binding site; other site 1207075003115 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1207075003116 putative dimer interface [polypeptide binding]; other site 1207075003117 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1207075003118 SLBB domain; Region: SLBB; pfam10531 1207075003119 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1207075003120 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1207075003121 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1207075003122 putative dimer interface [polypeptide binding]; other site 1207075003123 [2Fe-2S] cluster binding site [ion binding]; other site 1207075003124 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1207075003125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075003126 ATP binding site [chemical binding]; other site 1207075003127 putative Mg++ binding site [ion binding]; other site 1207075003128 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1207075003129 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1207075003130 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1207075003131 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1207075003132 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1207075003133 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1207075003134 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1207075003135 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1207075003136 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1207075003137 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1207075003138 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1207075003139 Protein export membrane protein; Region: SecD_SecF; pfam02355 1207075003140 hypothetical protein; Provisional; Region: PRK11280 1207075003141 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1207075003142 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1207075003143 active site 1207075003144 dimerization interface [polypeptide binding]; other site 1207075003145 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1207075003146 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1207075003147 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1207075003148 serine O-acetyltransferase; Region: cysE; TIGR01172 1207075003149 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1207075003150 trimer interface [polypeptide binding]; other site 1207075003151 active site 1207075003152 substrate binding site [chemical binding]; other site 1207075003153 CoA binding site [chemical binding]; other site 1207075003154 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1207075003155 Rrf2 family protein; Region: rrf2_super; TIGR00738 1207075003156 cysteine desulfurase; Provisional; Region: PRK14012 1207075003157 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1207075003158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075003159 catalytic residue [active] 1207075003160 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1207075003161 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1207075003162 trimerization site [polypeptide binding]; other site 1207075003163 active site 1207075003164 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1207075003165 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1207075003166 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1207075003167 HSP70 interaction site [polypeptide binding]; other site 1207075003168 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1207075003169 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1207075003170 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1207075003171 nucleotide binding site [chemical binding]; other site 1207075003172 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1207075003173 SBD interface [polypeptide binding]; other site 1207075003174 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1207075003175 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075003176 catalytic loop [active] 1207075003177 iron binding site [ion binding]; other site 1207075003178 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 1207075003179 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1207075003180 active site 1207075003181 multimer interface [polypeptide binding]; other site 1207075003182 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1207075003183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075003184 FeS/SAM binding site; other site 1207075003185 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1207075003186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075003187 binding surface 1207075003188 TPR motif; other site 1207075003189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075003190 binding surface 1207075003191 TPR motif; other site 1207075003192 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1207075003193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075003194 non-specific DNA binding site [nucleotide binding]; other site 1207075003195 salt bridge; other site 1207075003196 sequence-specific DNA binding site [nucleotide binding]; other site 1207075003197 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1207075003198 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1207075003199 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1207075003200 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1207075003201 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1207075003202 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1207075003203 dimer interface [polypeptide binding]; other site 1207075003204 motif 1; other site 1207075003205 active site 1207075003206 motif 2; other site 1207075003207 motif 3; other site 1207075003208 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1207075003209 anticodon binding site; other site 1207075003210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1207075003211 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1207075003212 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1207075003213 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1207075003214 Trp docking motif [polypeptide binding]; other site 1207075003215 active site 1207075003216 GTP-binding protein Der; Reviewed; Region: PRK00093 1207075003217 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1207075003218 G1 box; other site 1207075003219 GTP/Mg2+ binding site [chemical binding]; other site 1207075003220 Switch I region; other site 1207075003221 G2 box; other site 1207075003222 Switch II region; other site 1207075003223 G3 box; other site 1207075003224 G4 box; other site 1207075003225 G5 box; other site 1207075003226 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1207075003227 G1 box; other site 1207075003228 GTP/Mg2+ binding site [chemical binding]; other site 1207075003229 Switch I region; other site 1207075003230 G2 box; other site 1207075003231 G3 box; other site 1207075003232 Switch II region; other site 1207075003233 G4 box; other site 1207075003234 G5 box; other site 1207075003235 methionine aminotransferase; Validated; Region: PRK09082 1207075003236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075003238 homodimer interface [polypeptide binding]; other site 1207075003239 catalytic residue [active] 1207075003240 C-N hydrolase family amidase; Provisional; Region: PRK10438 1207075003241 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1207075003242 putative active site [active] 1207075003243 catalytic triad [active] 1207075003244 dimer interface [polypeptide binding]; other site 1207075003245 multimer interface [polypeptide binding]; other site 1207075003246 2-isopropylmalate synthase; Validated; Region: PRK03739 1207075003247 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1207075003248 active site 1207075003249 catalytic residues [active] 1207075003250 metal binding site [ion binding]; metal-binding site 1207075003251 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1207075003252 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1207075003253 Peptidase family M23; Region: Peptidase_M23; pfam01551 1207075003254 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1207075003255 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1207075003256 generic binding surface II; other site 1207075003257 generic binding surface I; other site 1207075003258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075003259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075003260 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1207075003261 dimerization interface [polypeptide binding]; other site 1207075003262 substrate binding pocket [chemical binding]; other site 1207075003263 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075003264 DNA polymerase III subunit chi; Validated; Region: PRK05728 1207075003265 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1207075003266 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1207075003267 interface (dimer of trimers) [polypeptide binding]; other site 1207075003268 Substrate-binding/catalytic site; other site 1207075003269 Zn-binding sites [ion binding]; other site 1207075003270 Predicted permeases [General function prediction only]; Region: COG0795 1207075003271 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1207075003272 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1207075003273 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1207075003274 GTP-binding protein LepA; Provisional; Region: PRK05433 1207075003275 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1207075003276 G1 box; other site 1207075003277 putative GEF interaction site [polypeptide binding]; other site 1207075003278 GTP/Mg2+ binding site [chemical binding]; other site 1207075003279 Switch I region; other site 1207075003280 G2 box; other site 1207075003281 G3 box; other site 1207075003282 Switch II region; other site 1207075003283 G4 box; other site 1207075003284 G5 box; other site 1207075003285 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1207075003286 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1207075003287 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1207075003288 signal peptidase I; Provisional; Region: PRK10861 1207075003289 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1207075003290 Catalytic site [active] 1207075003291 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1207075003292 ribonuclease III; Reviewed; Region: rnc; PRK00102 1207075003293 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1207075003294 dimerization interface [polypeptide binding]; other site 1207075003295 active site 1207075003296 metal binding site [ion binding]; metal-binding site 1207075003297 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1207075003298 dsRNA binding site [nucleotide binding]; other site 1207075003299 GTPase Era; Reviewed; Region: era; PRK00089 1207075003300 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1207075003301 G1 box; other site 1207075003302 GTP/Mg2+ binding site [chemical binding]; other site 1207075003303 Switch I region; other site 1207075003304 G2 box; other site 1207075003305 Switch II region; other site 1207075003306 G3 box; other site 1207075003307 G4 box; other site 1207075003308 G5 box; other site 1207075003309 KH domain; Region: KH_2; pfam07650 1207075003310 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1207075003311 Recombination protein O N terminal; Region: RecO_N; pfam11967 1207075003312 Recombination protein O C terminal; Region: RecO_C; pfam02565 1207075003313 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1207075003314 active site 1207075003315 hydrophilic channel; other site 1207075003316 dimerization interface [polypeptide binding]; other site 1207075003317 catalytic residues [active] 1207075003318 active site lid [active] 1207075003319 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1207075003320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075003321 substrate binding pocket [chemical binding]; other site 1207075003322 membrane-bound complex binding site; other site 1207075003323 hinge residues; other site 1207075003324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075003325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075003326 catalytic residue [active] 1207075003327 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1207075003328 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1207075003329 dimerization interface [polypeptide binding]; other site 1207075003330 ATP binding site [chemical binding]; other site 1207075003331 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1207075003332 dimerization interface [polypeptide binding]; other site 1207075003333 ATP binding site [chemical binding]; other site 1207075003334 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1207075003335 putative active site [active] 1207075003336 catalytic triad [active] 1207075003337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1207075003338 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1207075003339 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1207075003340 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1207075003341 active site turn [active] 1207075003342 phosphorylation site [posttranslational modification] 1207075003343 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1207075003344 active site turn [active] 1207075003345 phosphorylation site [posttranslational modification] 1207075003346 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1207075003347 HPr interaction site; other site 1207075003348 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1207075003349 active site 1207075003350 phosphorylation site [posttranslational modification] 1207075003351 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1207075003352 dimerization domain swap beta strand [polypeptide binding]; other site 1207075003353 regulatory protein interface [polypeptide binding]; other site 1207075003354 active site 1207075003355 regulatory phosphorylation site [posttranslational modification]; other site 1207075003356 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1207075003357 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1207075003358 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1207075003359 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1207075003360 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1207075003361 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1207075003362 dimer interface [polypeptide binding]; other site 1207075003363 active site 1207075003364 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1207075003365 dimer interface [polypeptide binding]; other site 1207075003366 active site 1207075003367 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1207075003368 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1207075003369 active site 1207075003370 dimer interface [polypeptide binding]; other site 1207075003371 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1207075003372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075003373 DNA-binding site [nucleotide binding]; DNA binding site 1207075003374 UTRA domain; Region: UTRA; pfam07702 1207075003375 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1207075003376 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1207075003377 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1207075003378 nudix motif; other site 1207075003379 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1207075003380 putative active site [active] 1207075003381 putative CoA binding site [chemical binding]; other site 1207075003382 nudix motif; other site 1207075003383 metal binding site [ion binding]; metal-binding site 1207075003384 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1207075003385 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1207075003386 trimer interface [polypeptide binding]; other site 1207075003387 putative metal binding site [ion binding]; other site 1207075003388 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1207075003389 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1207075003390 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1207075003391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075003392 ATP-grasp domain; Region: ATP-grasp; pfam02222 1207075003393 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1207075003394 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1207075003395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1207075003396 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1207075003397 active site 1207075003398 GMP synthase; Reviewed; Region: guaA; PRK00074 1207075003399 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1207075003400 AMP/PPi binding site [chemical binding]; other site 1207075003401 candidate oxyanion hole; other site 1207075003402 catalytic triad [active] 1207075003403 potential glutamine specificity residues [chemical binding]; other site 1207075003404 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1207075003405 ATP Binding subdomain [chemical binding]; other site 1207075003406 Ligand Binding sites [chemical binding]; other site 1207075003407 Dimerization subdomain; other site 1207075003408 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 1207075003409 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 1207075003410 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1207075003411 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1207075003412 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1207075003413 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1207075003414 nucleoside/Zn binding site; other site 1207075003415 dimer interface [polypeptide binding]; other site 1207075003416 catalytic motif [active] 1207075003417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075003418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075003419 S-adenosylmethionine binding site [chemical binding]; other site 1207075003420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075003421 S-adenosylmethionine binding site [chemical binding]; other site 1207075003422 YhhN-like protein; Region: YhhN; pfam07947 1207075003423 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1207075003424 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1207075003425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075003426 Walker A motif; other site 1207075003427 ATP binding site [chemical binding]; other site 1207075003428 Walker B motif; other site 1207075003429 arginine finger; other site 1207075003430 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1207075003431 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1207075003432 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1207075003433 Trp docking motif [polypeptide binding]; other site 1207075003434 putative active site [active] 1207075003435 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1207075003436 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1207075003437 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1207075003438 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1207075003439 FAD binding pocket [chemical binding]; other site 1207075003440 FAD binding motif [chemical binding]; other site 1207075003441 phosphate binding motif [ion binding]; other site 1207075003442 NAD binding pocket [chemical binding]; other site 1207075003443 Predicted transcriptional regulators [Transcription]; Region: COG1695 1207075003444 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1207075003445 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 1207075003446 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1207075003447 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1207075003448 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1207075003449 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 1207075003450 Leucine rich repeat; Region: LRR_8; pfam13855 1207075003451 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1207075003452 Transglycosylase; Region: Transgly; cl17702 1207075003453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1207075003454 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1207075003455 Spore germination protein; Region: Spore_permease; cl17796 1207075003456 OpgC protein; Region: OpgC_C; pfam10129 1207075003457 GtrA-like protein; Region: GtrA; pfam04138 1207075003458 Predicted membrane protein [Function unknown]; Region: COG2246 1207075003459 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1207075003460 Ligand binding site; other site 1207075003461 Putative Catalytic site; other site 1207075003462 DXD motif; other site 1207075003463 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1207075003464 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1207075003465 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1207075003466 active site 1207075003467 FMN binding site [chemical binding]; other site 1207075003468 substrate binding site [chemical binding]; other site 1207075003469 3Fe-4S cluster binding site [ion binding]; other site 1207075003470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075003471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075003472 DNA binding residues [nucleotide binding] 1207075003473 dimerization interface [polypeptide binding]; other site 1207075003474 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075003475 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1207075003476 putative active site [active] 1207075003477 catalytic triad [active] 1207075003478 putative dimer interface [polypeptide binding]; other site 1207075003479 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1207075003480 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1207075003481 nudix motif; other site 1207075003482 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075003483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075003484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075003485 Coenzyme A binding pocket [chemical binding]; other site 1207075003486 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1207075003487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075003488 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1207075003489 putative dimerization interface [polypeptide binding]; other site 1207075003490 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1207075003491 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1207075003492 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075003493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075003494 active site 1207075003495 phosphorylation site [posttranslational modification] 1207075003496 intermolecular recognition site; other site 1207075003497 dimerization interface [polypeptide binding]; other site 1207075003498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075003499 Walker A motif; other site 1207075003500 ATP binding site [chemical binding]; other site 1207075003501 Walker B motif; other site 1207075003502 arginine finger; other site 1207075003503 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075003504 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1207075003505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075003506 dimer interface [polypeptide binding]; other site 1207075003507 phosphorylation site [posttranslational modification] 1207075003508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075003509 ATP binding site [chemical binding]; other site 1207075003510 Mg2+ binding site [ion binding]; other site 1207075003511 G-X-G motif; other site 1207075003512 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1207075003513 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075003514 Walker A/P-loop; other site 1207075003515 ATP binding site [chemical binding]; other site 1207075003516 Q-loop/lid; other site 1207075003517 ABC transporter signature motif; other site 1207075003518 Walker B; other site 1207075003519 D-loop; other site 1207075003520 H-loop/switch region; other site 1207075003521 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075003522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075003523 dimer interface [polypeptide binding]; other site 1207075003524 conserved gate region; other site 1207075003525 putative PBP binding loops; other site 1207075003526 ABC-ATPase subunit interface; other site 1207075003527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075003528 dimer interface [polypeptide binding]; other site 1207075003529 conserved gate region; other site 1207075003530 putative PBP binding loops; other site 1207075003531 ABC-ATPase subunit interface; other site 1207075003532 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1207075003533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075003534 substrate binding pocket [chemical binding]; other site 1207075003535 membrane-bound complex binding site; other site 1207075003536 hinge residues; other site 1207075003537 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1207075003538 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1207075003539 BRO family, N-terminal domain; Region: Bro-N; smart01040 1207075003540 AAA domain; Region: AAA_21; pfam13304 1207075003541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075003542 Walker B; other site 1207075003543 D-loop; other site 1207075003544 H-loop/switch region; other site 1207075003545 RloB-like protein; Region: RloB; pfam13707 1207075003546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075003547 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1207075003548 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1207075003549 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1207075003550 tetrameric interface [polypeptide binding]; other site 1207075003551 NAD binding site [chemical binding]; other site 1207075003552 catalytic residues [active] 1207075003553 substrate binding site [chemical binding]; other site 1207075003554 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075003556 dimer interface [polypeptide binding]; other site 1207075003557 conserved gate region; other site 1207075003558 putative PBP binding loops; other site 1207075003559 ABC-ATPase subunit interface; other site 1207075003560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075003561 dimer interface [polypeptide binding]; other site 1207075003562 putative PBP binding loops; other site 1207075003563 ABC-ATPase subunit interface; other site 1207075003564 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075003566 Walker A/P-loop; other site 1207075003567 ATP binding site [chemical binding]; other site 1207075003568 Q-loop/lid; other site 1207075003569 ABC transporter signature motif; other site 1207075003570 Walker B; other site 1207075003571 D-loop; other site 1207075003572 H-loop/switch region; other site 1207075003573 TOBE domain; Region: TOBE_2; pfam08402 1207075003574 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1207075003575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075003576 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1207075003577 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1207075003578 tetrameric interface [polypeptide binding]; other site 1207075003579 NAD binding site [chemical binding]; other site 1207075003580 catalytic residues [active] 1207075003581 substrate binding site [chemical binding]; other site 1207075003582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075003583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075003584 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1207075003585 putative substrate binding pocket [chemical binding]; other site 1207075003586 dimerization interface [polypeptide binding]; other site 1207075003587 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1207075003588 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1207075003589 putative metal binding site [ion binding]; other site 1207075003590 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1207075003591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075003592 dimerization interface [polypeptide binding]; other site 1207075003593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075003594 dimer interface [polypeptide binding]; other site 1207075003595 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1207075003596 putative CheW interface [polypeptide binding]; other site 1207075003597 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1207075003598 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1207075003599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075003600 S-adenosylmethionine binding site [chemical binding]; other site 1207075003601 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1207075003602 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075003603 putative binding surface; other site 1207075003604 active site 1207075003605 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1207075003606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075003607 ATP binding site [chemical binding]; other site 1207075003608 Mg2+ binding site [ion binding]; other site 1207075003609 G-X-G motif; other site 1207075003610 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1207075003611 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075003612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075003613 active site 1207075003614 phosphorylation site [posttranslational modification] 1207075003615 intermolecular recognition site; other site 1207075003616 dimerization interface [polypeptide binding]; other site 1207075003617 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1207075003618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075003619 active site 1207075003620 phosphorylation site [posttranslational modification] 1207075003621 intermolecular recognition site; other site 1207075003622 CheB methylesterase; Region: CheB_methylest; pfam01339 1207075003623 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075003624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075003625 active site 1207075003626 phosphorylation site [posttranslational modification] 1207075003627 intermolecular recognition site; other site 1207075003628 dimerization interface [polypeptide binding]; other site 1207075003629 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075003630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075003631 metal binding site [ion binding]; metal-binding site 1207075003632 active site 1207075003633 I-site; other site 1207075003634 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1207075003635 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1207075003636 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1207075003637 RF-1 domain; Region: RF-1; pfam00472 1207075003638 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1207075003639 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1207075003640 dimer interface [polypeptide binding]; other site 1207075003641 putative anticodon binding site; other site 1207075003642 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1207075003643 motif 1; other site 1207075003644 active site 1207075003645 motif 2; other site 1207075003646 motif 3; other site 1207075003647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1207075003648 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1207075003649 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075003650 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075003651 Secretory lipase; Region: LIP; pfam03583 1207075003652 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075003653 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075003654 ligand binding site [chemical binding]; other site 1207075003655 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1207075003656 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1207075003657 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1207075003658 adenylate kinase; Reviewed; Region: adk; PRK00279 1207075003659 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1207075003660 AMP-binding site [chemical binding]; other site 1207075003661 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1207075003662 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1207075003663 Glycoprotease family; Region: Peptidase_M22; pfam00814 1207075003664 Protein of unknown function DUF72; Region: DUF72; cl00777 1207075003665 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1207075003666 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1207075003667 tetramer interface [polypeptide binding]; other site 1207075003668 active site 1207075003669 Mg2+/Mn2+ binding site [ion binding]; other site 1207075003670 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1207075003671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075003672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075003673 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1207075003674 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075003675 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075003676 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075003677 putative membrane fusion protein; Region: TIGR02828 1207075003678 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1207075003679 Fic family protein [Function unknown]; Region: COG3177 1207075003680 Fic/DOC family; Region: Fic; pfam02661 1207075003681 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1207075003682 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1207075003683 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1207075003684 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1207075003685 putative acyl-acceptor binding pocket; other site 1207075003686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1207075003687 DNA-binding site [nucleotide binding]; DNA binding site 1207075003688 RNA-binding motif; other site 1207075003689 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1207075003690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075003691 S-adenosylmethionine binding site [chemical binding]; other site 1207075003692 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1207075003693 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1207075003694 metal binding site [ion binding]; metal-binding site 1207075003695 dimer interface [polypeptide binding]; other site 1207075003696 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1207075003697 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075003698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075003699 active site 1207075003700 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1207075003701 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1207075003702 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1207075003703 putative ATP binding site [chemical binding]; other site 1207075003704 putative substrate interface [chemical binding]; other site 1207075003705 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1207075003706 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1207075003707 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1207075003708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075003709 catalytic residue [active] 1207075003710 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1207075003711 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1207075003712 putative trimer interface [polypeptide binding]; other site 1207075003713 putative CoA binding site [chemical binding]; other site 1207075003714 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1207075003715 ArsC family; Region: ArsC; pfam03960 1207075003716 putative catalytic residues [active] 1207075003717 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1207075003718 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1207075003719 active site 1207075003720 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1207075003721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075003722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075003723 homodimer interface [polypeptide binding]; other site 1207075003724 catalytic residue [active] 1207075003725 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1207075003726 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1207075003727 metal binding triad; other site 1207075003728 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1207075003729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075003730 Zn2+ binding site [ion binding]; other site 1207075003731 Mg2+ binding site [ion binding]; other site 1207075003732 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1207075003733 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1207075003734 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1207075003735 active site 1207075003736 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1207075003737 rRNA interaction site [nucleotide binding]; other site 1207075003738 S8 interaction site; other site 1207075003739 putative laminin-1 binding site; other site 1207075003740 elongation factor Ts; Provisional; Region: tsf; PRK09377 1207075003741 UBA/TS-N domain; Region: UBA; pfam00627 1207075003742 Elongation factor TS; Region: EF_TS; pfam00889 1207075003743 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1207075003744 putative nucleotide binding site [chemical binding]; other site 1207075003745 uridine monophosphate binding site [chemical binding]; other site 1207075003746 homohexameric interface [polypeptide binding]; other site 1207075003747 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1207075003748 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1207075003749 hinge region; other site 1207075003750 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1207075003751 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1207075003752 catalytic residue [active] 1207075003753 putative FPP diphosphate binding site; other site 1207075003754 putative FPP binding hydrophobic cleft; other site 1207075003755 dimer interface [polypeptide binding]; other site 1207075003756 putative IPP diphosphate binding site; other site 1207075003757 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1207075003758 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1207075003759 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1207075003760 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1207075003761 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1207075003762 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1207075003763 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1207075003764 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1207075003765 active site 1207075003766 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1207075003767 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1207075003768 protein binding site [polypeptide binding]; other site 1207075003769 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1207075003770 putative substrate binding region [chemical binding]; other site 1207075003771 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1207075003772 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1207075003773 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1207075003774 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1207075003775 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1207075003776 Surface antigen; Region: Bac_surface_Ag; pfam01103 1207075003777 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 1207075003778 periplasmic chaperone; Provisional; Region: PRK10780 1207075003779 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1207075003780 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1207075003781 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1207075003782 trimer interface [polypeptide binding]; other site 1207075003783 active site 1207075003784 UDP-GlcNAc binding site [chemical binding]; other site 1207075003785 lipid binding site [chemical binding]; lipid-binding site 1207075003786 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1207075003787 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1207075003788 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1207075003789 active site 1207075003790 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1207075003791 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1207075003792 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1207075003793 RNA/DNA hybrid binding site [nucleotide binding]; other site 1207075003794 active site 1207075003795 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1207075003796 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1207075003797 putative active site [active] 1207075003798 putative PHP Thumb interface [polypeptide binding]; other site 1207075003799 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1207075003800 generic binding surface II; other site 1207075003801 generic binding surface I; other site 1207075003802 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1207075003803 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1207075003804 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1207075003805 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1207075003806 Ligand Binding Site [chemical binding]; other site 1207075003807 TilS substrate binding domain; Region: TilS; pfam09179 1207075003808 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1207075003809 CTP synthetase; Validated; Region: pyrG; PRK05380 1207075003810 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1207075003811 Catalytic site [active] 1207075003812 active site 1207075003813 UTP binding site [chemical binding]; other site 1207075003814 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1207075003815 active site 1207075003816 putative oxyanion hole; other site 1207075003817 catalytic triad [active] 1207075003818 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1207075003819 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1207075003820 enolase; Provisional; Region: eno; PRK00077 1207075003821 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1207075003822 dimer interface [polypeptide binding]; other site 1207075003823 metal binding site [ion binding]; metal-binding site 1207075003824 substrate binding pocket [chemical binding]; other site 1207075003825 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1207075003826 Septum formation initiator; Region: DivIC; cl17659 1207075003827 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1207075003828 substrate binding site; other site 1207075003829 dimer interface; other site 1207075003830 LysR family transcriptional regulator; Provisional; Region: PRK14997 1207075003831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075003832 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1207075003833 putative effector binding pocket; other site 1207075003834 putative dimerization interface [polypeptide binding]; other site 1207075003835 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1207075003836 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1207075003837 substrate binding site [chemical binding]; other site 1207075003838 catalytic Zn binding site [ion binding]; other site 1207075003839 NAD binding site [chemical binding]; other site 1207075003840 structural Zn binding site [ion binding]; other site 1207075003841 dimer interface [polypeptide binding]; other site 1207075003842 S-formylglutathione hydrolase; Region: PLN02442 1207075003843 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1207075003844 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1207075003845 homotrimer interaction site [polypeptide binding]; other site 1207075003846 zinc binding site [ion binding]; other site 1207075003847 CDP-binding sites; other site 1207075003848 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1207075003849 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1207075003850 Permutation of conserved domain; other site 1207075003851 active site 1207075003852 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1207075003853 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1207075003854 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1207075003855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075003856 S-adenosylmethionine binding site [chemical binding]; other site 1207075003857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1207075003858 Peptidase family M23; Region: Peptidase_M23; pfam01551 1207075003859 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1207075003860 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1207075003861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075003862 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1207075003863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075003864 DNA binding residues [nucleotide binding] 1207075003865 Ferredoxin [Energy production and conversion]; Region: COG1146 1207075003866 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1207075003867 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1207075003868 MutS domain I; Region: MutS_I; pfam01624 1207075003869 MutS domain II; Region: MutS_II; pfam05188 1207075003870 MutS domain III; Region: MutS_III; pfam05192 1207075003871 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1207075003872 Walker A/P-loop; other site 1207075003873 ATP binding site [chemical binding]; other site 1207075003874 Q-loop/lid; other site 1207075003875 ABC transporter signature motif; other site 1207075003876 Walker B; other site 1207075003877 D-loop; other site 1207075003878 H-loop/switch region; other site 1207075003879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075003880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1207075003881 non-specific DNA binding site [nucleotide binding]; other site 1207075003882 salt bridge; other site 1207075003883 sequence-specific DNA binding site [nucleotide binding]; other site 1207075003884 Predicted transcriptional regulator [Transcription]; Region: COG2932 1207075003885 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1207075003886 Catalytic site [active] 1207075003887 Competence-damaged protein; Region: CinA; pfam02464 1207075003888 recombinase A; Provisional; Region: recA; PRK09354 1207075003889 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1207075003890 hexamer interface [polypeptide binding]; other site 1207075003891 Walker A motif; other site 1207075003892 ATP binding site [chemical binding]; other site 1207075003893 Walker B motif; other site 1207075003894 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1207075003895 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1207075003896 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1207075003897 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1207075003898 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075003899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075003900 active site 1207075003901 phosphorylation site [posttranslational modification] 1207075003902 intermolecular recognition site; other site 1207075003903 dimerization interface [polypeptide binding]; other site 1207075003904 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075003905 DNA binding residues [nucleotide binding] 1207075003906 dimerization interface [polypeptide binding]; other site 1207075003907 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1207075003908 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1207075003909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075003910 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1207075003911 putative dimerization interface [polypeptide binding]; other site 1207075003912 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1207075003913 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1207075003914 FAD binding pocket [chemical binding]; other site 1207075003915 FAD binding motif [chemical binding]; other site 1207075003916 phosphate binding motif [ion binding]; other site 1207075003917 beta-alpha-beta structure motif; other site 1207075003918 NAD binding pocket [chemical binding]; other site 1207075003919 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1207075003920 homodimer interaction site [polypeptide binding]; other site 1207075003921 cofactor binding site; other site 1207075003922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075003923 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1207075003924 NAD(P) binding site [chemical binding]; other site 1207075003925 active site 1207075003926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1207075003927 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1207075003928 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1207075003929 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1207075003930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075003931 RNA binding surface [nucleotide binding]; other site 1207075003932 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1207075003933 active site 1207075003934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075003935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075003936 Coenzyme A binding pocket [chemical binding]; other site 1207075003937 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1207075003938 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1207075003939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075003940 FeS/SAM binding site; other site 1207075003941 TRAM domain; Region: TRAM; cl01282 1207075003942 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1207075003943 potassium uptake protein; Region: kup; TIGR00794 1207075003944 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1207075003945 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1207075003946 Predicted integral membrane protein [Function unknown]; Region: COG0392 1207075003947 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1207075003948 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1207075003949 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1207075003950 active site 1207075003951 DNA polymerase IV; Validated; Region: PRK02406 1207075003952 DNA binding site [nucleotide binding] 1207075003953 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1207075003954 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1207075003955 dimer interface [polypeptide binding]; other site 1207075003956 motif 1; other site 1207075003957 active site 1207075003958 motif 2; other site 1207075003959 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1207075003960 putative deacylase active site [active] 1207075003961 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1207075003962 active site 1207075003963 motif 3; other site 1207075003964 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1207075003965 anticodon binding site; other site 1207075003966 muropeptide transporter; Validated; Region: ampG; cl17669 1207075003967 muropeptide transporter; Validated; Region: ampG; cl17669 1207075003968 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1207075003969 DNA binding site [nucleotide binding] 1207075003970 active site 1207075003971 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1207075003972 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1207075003973 DNA-binding site [nucleotide binding]; DNA binding site 1207075003974 RNA-binding motif; other site 1207075003975 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1207075003976 trimer interface [polypeptide binding]; other site 1207075003977 active site 1207075003978 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1207075003979 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075003980 Walker A/P-loop; other site 1207075003981 ATP binding site [chemical binding]; other site 1207075003982 Q-loop/lid; other site 1207075003983 ABC transporter signature motif; other site 1207075003984 Walker B; other site 1207075003985 D-loop; other site 1207075003986 H-loop/switch region; other site 1207075003987 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1207075003988 active site 1207075003989 Zn binding site [ion binding]; other site 1207075003990 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075003991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075003992 dimer interface [polypeptide binding]; other site 1207075003993 conserved gate region; other site 1207075003994 putative PBP binding loops; other site 1207075003995 ABC-ATPase subunit interface; other site 1207075003996 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075003997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075003998 dimer interface [polypeptide binding]; other site 1207075003999 conserved gate region; other site 1207075004000 putative PBP binding loops; other site 1207075004001 ABC-ATPase subunit interface; other site 1207075004002 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075004003 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075004004 substrate binding pocket [chemical binding]; other site 1207075004005 membrane-bound complex binding site; other site 1207075004006 hinge residues; other site 1207075004007 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1207075004008 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1207075004009 active site 1207075004010 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075004011 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1207075004012 catalytic triad [active] 1207075004013 conserved cis-peptide bond; other site 1207075004014 SEC-C motif; Region: SEC-C; pfam02810 1207075004015 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1207075004016 hypothetical protein; Provisional; Region: PRK00183 1207075004017 SEC-C motif; Region: SEC-C; pfam02810 1207075004018 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075004019 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075004020 ligand binding site [chemical binding]; other site 1207075004021 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075004022 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075004023 ligand binding site [chemical binding]; other site 1207075004024 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 1207075004025 Predicted integral membrane protein [Function unknown]; Region: COG5615 1207075004026 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1207075004027 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1207075004028 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1207075004029 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1207075004030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1207075004031 Beta-lactamase; Region: Beta-lactamase; pfam00144 1207075004032 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075004033 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075004034 ligand binding site [chemical binding]; other site 1207075004035 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1207075004036 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1207075004037 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1207075004038 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1207075004039 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1207075004040 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1207075004041 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1207075004042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075004043 catalytic residue [active] 1207075004044 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1207075004045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075004046 Predicted membrane protein [Function unknown]; Region: COG3650 1207075004047 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1207075004048 short chain dehydrogenase; Provisional; Region: PRK12827 1207075004049 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1207075004050 putative NAD(P) binding site [chemical binding]; other site 1207075004051 homodimer interface [polypeptide binding]; other site 1207075004052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075004053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075004054 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075004055 putative effector binding pocket; other site 1207075004056 dimerization interface [polypeptide binding]; other site 1207075004057 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1207075004058 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1207075004059 Walker A/P-loop; other site 1207075004060 ATP binding site [chemical binding]; other site 1207075004061 Q-loop/lid; other site 1207075004062 ABC transporter signature motif; other site 1207075004063 Walker B; other site 1207075004064 D-loop; other site 1207075004065 H-loop/switch region; other site 1207075004066 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1207075004067 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1207075004068 Walker A/P-loop; other site 1207075004069 ATP binding site [chemical binding]; other site 1207075004070 Q-loop/lid; other site 1207075004071 ABC transporter signature motif; other site 1207075004072 Walker B; other site 1207075004073 D-loop; other site 1207075004074 H-loop/switch region; other site 1207075004075 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1207075004076 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1207075004077 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1207075004078 TM-ABC transporter signature motif; other site 1207075004079 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075004080 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1207075004081 TM-ABC transporter signature motif; other site 1207075004082 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1207075004083 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1207075004084 dimerization interface [polypeptide binding]; other site 1207075004085 ligand binding site [chemical binding]; other site 1207075004086 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1207075004087 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1207075004088 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1207075004089 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1207075004090 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1207075004091 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1207075004092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075004093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075004094 metal binding site [ion binding]; metal-binding site 1207075004095 active site 1207075004096 I-site; other site 1207075004097 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075004098 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1207075004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075004100 putative substrate translocation pore; other site 1207075004101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075004102 ATP-dependent helicase HepA; Validated; Region: PRK04914 1207075004103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075004104 ATP binding site [chemical binding]; other site 1207075004105 putative Mg++ binding site [ion binding]; other site 1207075004106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075004107 nucleotide binding region [chemical binding]; other site 1207075004108 ATP-binding site [chemical binding]; other site 1207075004109 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1207075004110 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1207075004111 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1207075004112 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1207075004113 Bacterial transcriptional regulator; Region: IclR; pfam01614 1207075004114 benzoate transport; Region: 2A0115; TIGR00895 1207075004115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075004116 putative substrate translocation pore; other site 1207075004117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075004118 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1207075004119 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1207075004120 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1207075004121 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075004122 dimer interface [polypeptide binding]; other site 1207075004123 active site 1207075004124 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1207075004125 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1207075004126 heterodimer interface [polypeptide binding]; other site 1207075004127 multimer interface [polypeptide binding]; other site 1207075004128 active site 1207075004129 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1207075004130 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1207075004131 heterodimer interface [polypeptide binding]; other site 1207075004132 active site 1207075004133 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1207075004134 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1207075004135 tetramer interface [polypeptide binding]; other site 1207075004136 active site 1207075004137 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1207075004138 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1207075004139 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075004140 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1207075004141 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1207075004142 Protein export membrane protein; Region: SecD_SecF; cl14618 1207075004143 Protein export membrane protein; Region: SecD_SecF; cl14618 1207075004144 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1207075004145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075004146 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075004147 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1207075004148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075004149 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1207075004150 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075004151 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1207075004152 FMN binding site [chemical binding]; other site 1207075004153 active site 1207075004154 substrate binding site [chemical binding]; other site 1207075004155 catalytic residue [active] 1207075004156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075004157 putative substrate translocation pore; other site 1207075004158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075004159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075004160 dimerization interface [polypeptide binding]; other site 1207075004161 putative DNA binding site [nucleotide binding]; other site 1207075004162 putative Zn2+ binding site [ion binding]; other site 1207075004163 Protein of unknown function, DUF479; Region: DUF479; cl01203 1207075004164 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075004165 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1207075004166 putative acyl-acceptor binding pocket; other site 1207075004167 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1207075004168 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075004169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075004170 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1207075004171 Beta-lactamase; Region: Beta-lactamase; pfam00144 1207075004172 YceI-like domain; Region: YceI; pfam04264 1207075004173 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1207075004174 PLD-like domain; Region: PLDc_2; pfam13091 1207075004175 putative active site [active] 1207075004176 catalytic site [active] 1207075004177 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1207075004178 PLD-like domain; Region: PLDc_2; pfam13091 1207075004179 putative active site [active] 1207075004180 catalytic site [active] 1207075004181 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1207075004182 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1207075004183 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1207075004184 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1207075004185 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1207075004186 Repair protein; Region: Repair_PSII; pfam04536 1207075004187 Repair protein; Region: Repair_PSII; cl01535 1207075004188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075004189 DNA binding residues [nucleotide binding] 1207075004190 dimerization interface [polypeptide binding]; other site 1207075004191 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1207075004192 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075004193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075004194 S-adenosylmethionine binding site [chemical binding]; other site 1207075004195 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075004196 EamA-like transporter family; Region: EamA; pfam00892 1207075004197 EamA-like transporter family; Region: EamA; pfam00892 1207075004198 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1207075004199 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1207075004200 conserved cys residue [active] 1207075004201 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1207075004202 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1207075004203 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1207075004204 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1207075004205 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1207075004206 inhibitor site; inhibition site 1207075004207 active site 1207075004208 dimer interface [polypeptide binding]; other site 1207075004209 catalytic residue [active] 1207075004210 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1207075004211 intersubunit interface [polypeptide binding]; other site 1207075004212 active site 1207075004213 Zn2+ binding site [ion binding]; other site 1207075004214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075004215 non-specific DNA binding site [nucleotide binding]; other site 1207075004216 salt bridge; other site 1207075004217 sequence-specific DNA binding site [nucleotide binding]; other site 1207075004218 Cupin domain; Region: Cupin_2; pfam07883 1207075004219 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075004220 PAS fold; Region: PAS; pfam00989 1207075004221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075004222 putative active site [active] 1207075004223 heme pocket [chemical binding]; other site 1207075004224 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1207075004225 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1207075004226 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075004227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075004228 metal binding site [ion binding]; metal-binding site 1207075004229 active site 1207075004230 I-site; other site 1207075004231 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1207075004232 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1207075004233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075004234 S-adenosylmethionine binding site [chemical binding]; other site 1207075004235 Fic/DOC family; Region: Fic; pfam02661 1207075004236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075004237 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075004238 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075004239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075004240 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1207075004241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075004242 RNA binding surface [nucleotide binding]; other site 1207075004243 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1207075004244 active site 1207075004245 uracil binding [chemical binding]; other site 1207075004246 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1207075004247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075004248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075004249 metal binding site [ion binding]; metal-binding site 1207075004250 active site 1207075004251 I-site; other site 1207075004252 allophanate hydrolase; Provisional; Region: PRK08186 1207075004253 Amidase; Region: Amidase; cl11426 1207075004254 urea carboxylase; Region: urea_carbox; TIGR02712 1207075004255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075004256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1207075004257 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1207075004258 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1207075004259 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1207075004260 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1207075004261 carboxyltransferase (CT) interaction site; other site 1207075004262 biotinylation site [posttranslational modification]; other site 1207075004263 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1207075004264 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1207075004265 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1207075004266 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1207075004267 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1207075004268 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075004269 Walker A/P-loop; other site 1207075004270 ATP binding site [chemical binding]; other site 1207075004271 Q-loop/lid; other site 1207075004272 ABC transporter signature motif; other site 1207075004273 Walker B; other site 1207075004274 D-loop; other site 1207075004275 H-loop/switch region; other site 1207075004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1207075004277 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1207075004278 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1207075004279 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1207075004280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075004281 substrate binding site [chemical binding]; other site 1207075004282 oxyanion hole (OAH) forming residues; other site 1207075004283 trimer interface [polypeptide binding]; other site 1207075004284 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1207075004285 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1207075004286 ligand binding site [chemical binding]; other site 1207075004287 active site 1207075004288 UGI interface [polypeptide binding]; other site 1207075004289 catalytic site [active] 1207075004290 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1207075004291 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1207075004292 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1207075004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1207075004294 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1207075004295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1207075004296 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1207075004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004298 active site 1207075004299 phosphorylation site [posttranslational modification] 1207075004300 intermolecular recognition site; other site 1207075004301 dimerization interface [polypeptide binding]; other site 1207075004302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075004303 DNA binding site [nucleotide binding] 1207075004304 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1207075004305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075004306 HAMP domain; Region: HAMP; pfam00672 1207075004307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075004308 dimer interface [polypeptide binding]; other site 1207075004309 phosphorylation site [posttranslational modification] 1207075004310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075004311 ATP binding site [chemical binding]; other site 1207075004312 Mg2+ binding site [ion binding]; other site 1207075004313 G-X-G motif; other site 1207075004314 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1207075004315 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1207075004316 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1207075004317 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1207075004318 L-aspartate oxidase; Provisional; Region: PRK09077 1207075004319 L-aspartate oxidase; Provisional; Region: PRK06175 1207075004320 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1207075004321 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1207075004322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075004323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075004324 DNA binding residues [nucleotide binding] 1207075004325 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1207075004326 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1207075004327 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1207075004328 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1207075004329 MucB/RseB family; Region: MucB_RseB; pfam03888 1207075004330 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1207075004331 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1207075004332 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1207075004333 protein binding site [polypeptide binding]; other site 1207075004334 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1207075004335 protein binding site [polypeptide binding]; other site 1207075004336 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1207075004337 Peptidase family M48; Region: Peptidase_M48; cl12018 1207075004338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1207075004339 TPR motif; other site 1207075004340 binding surface 1207075004341 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1207075004342 CPxP motif; other site 1207075004343 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1207075004344 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1207075004345 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1207075004346 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1207075004347 catalytic triad [active] 1207075004348 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1207075004349 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1207075004350 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1207075004351 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1207075004352 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1207075004353 dimer interface [polypeptide binding]; other site 1207075004354 active site 1207075004355 catalytic residue [active] 1207075004356 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1207075004357 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1207075004358 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1207075004359 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1207075004360 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1207075004361 ATP binding site [chemical binding]; other site 1207075004362 active site 1207075004363 substrate binding site [chemical binding]; other site 1207075004364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075004365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075004366 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1207075004367 putative substrate binding pocket [chemical binding]; other site 1207075004368 putative dimerization interface [polypeptide binding]; other site 1207075004369 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1207075004370 putative substrate binding pocket [chemical binding]; other site 1207075004371 trimer interface [polypeptide binding]; other site 1207075004372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075004373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075004374 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1207075004375 substrate binding pocket [chemical binding]; other site 1207075004376 dimerization interface [polypeptide binding]; other site 1207075004377 EamA-like transporter family; Region: EamA; pfam00892 1207075004378 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1207075004379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075004380 putative substrate translocation pore; other site 1207075004381 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075004382 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075004383 putative metal dependent hydrolase; Provisional; Region: PRK11598 1207075004384 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1207075004385 Sulfatase; Region: Sulfatase; pfam00884 1207075004386 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1207075004387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075004388 S-adenosylmethionine binding site [chemical binding]; other site 1207075004389 ribonuclease D; Region: rnd; TIGR01388 1207075004390 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1207075004391 catalytic site [active] 1207075004392 putative active site [active] 1207075004393 putative substrate binding site [chemical binding]; other site 1207075004394 HRDC domain; Region: HRDC; pfam00570 1207075004395 YcgL domain; Region: YcgL; cl01189 1207075004396 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1207075004397 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1207075004398 NAD binding site [chemical binding]; other site 1207075004399 ligand binding site [chemical binding]; other site 1207075004400 catalytic site [active] 1207075004401 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1207075004402 putative FMN binding site [chemical binding]; other site 1207075004403 hypothetical protein; Provisional; Region: PRK05170 1207075004404 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075004405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075004406 DNA-binding site [nucleotide binding]; DNA binding site 1207075004407 FCD domain; Region: FCD; pfam07729 1207075004408 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1207075004409 short chain dehydrogenase; Provisional; Region: PRK07063 1207075004410 classical (c) SDRs; Region: SDR_c; cd05233 1207075004411 NAD(P) binding site [chemical binding]; other site 1207075004412 active site 1207075004413 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1207075004414 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1207075004415 ligand binding site [chemical binding]; other site 1207075004416 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1207075004417 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1207075004418 Walker A/P-loop; other site 1207075004419 ATP binding site [chemical binding]; other site 1207075004420 Q-loop/lid; other site 1207075004421 ABC transporter signature motif; other site 1207075004422 Walker B; other site 1207075004423 D-loop; other site 1207075004424 H-loop/switch region; other site 1207075004425 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1207075004426 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1207075004427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075004428 TM-ABC transporter signature motif; other site 1207075004429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075004430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075004431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075004432 Coenzyme A binding pocket [chemical binding]; other site 1207075004433 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1207075004434 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1207075004435 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1207075004436 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1207075004437 active site 1207075004438 intersubunit interface [polypeptide binding]; other site 1207075004439 catalytic residue [active] 1207075004440 galactonate dehydratase; Provisional; Region: PRK14017 1207075004441 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1207075004442 putative active site pocket [active] 1207075004443 putative metal binding site [ion binding]; other site 1207075004444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075004445 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075004446 putative substrate translocation pore; other site 1207075004447 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1207075004448 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1207075004449 Bacterial transcriptional regulator; Region: IclR; pfam01614 1207075004450 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1207075004451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075004452 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1207075004453 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1207075004454 Ligand binding site [chemical binding]; other site 1207075004455 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1207075004456 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1207075004457 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1207075004458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075004459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075004460 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1207075004461 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075004462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075004463 ligand binding site [chemical binding]; other site 1207075004464 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075004465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075004466 DNA-binding site [nucleotide binding]; DNA binding site 1207075004467 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075004468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075004469 homodimer interface [polypeptide binding]; other site 1207075004470 catalytic residue [active] 1207075004471 Flagellin N-methylase; Region: FliB; cl00497 1207075004472 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1207075004473 putative lipid binding site [chemical binding]; other site 1207075004474 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1207075004475 Sulfatase; Region: Sulfatase; pfam00884 1207075004476 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1207075004477 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1207075004478 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1207075004479 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1207075004480 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1207075004481 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1207075004482 short chain dehydrogenase; Provisional; Region: PRK05650 1207075004483 classical (c) SDRs; Region: SDR_c; cd05233 1207075004484 NAD(P) binding site [chemical binding]; other site 1207075004485 active site 1207075004486 hypothetical protein; Provisional; Region: PRK02237 1207075004487 carbon storage regulator; Provisional; Region: PRK01712 1207075004488 hypothetical protein; Provisional; Region: PRK00304 1207075004489 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1207075004490 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1207075004491 putative oligomer interface [polypeptide binding]; other site 1207075004492 putative active site [active] 1207075004493 metal binding site [ion binding]; metal-binding site 1207075004494 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1207075004495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075004496 Coenzyme A binding pocket [chemical binding]; other site 1207075004497 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1207075004498 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1207075004499 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1207075004500 active site 1207075004501 dimer interface [polypeptide binding]; other site 1207075004502 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1207075004503 Ligand Binding Site [chemical binding]; other site 1207075004504 Molecular Tunnel; other site 1207075004505 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1207075004506 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1207075004507 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1207075004508 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1207075004509 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1207075004510 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1207075004511 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075004512 dimer interface [polypeptide binding]; other site 1207075004513 active site 1207075004514 EamA-like transporter family; Region: EamA; cl17759 1207075004515 fumarate hydratase; Provisional; Region: PRK12425 1207075004516 Class II fumarases; Region: Fumarase_classII; cd01362 1207075004517 active site 1207075004518 tetramer interface [polypeptide binding]; other site 1207075004519 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1207075004520 BolA-like protein; Region: BolA; pfam01722 1207075004521 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1207075004522 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1207075004523 active site residue [active] 1207075004524 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1207075004525 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1207075004526 catalytic residues [active] 1207075004527 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1207075004528 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075004529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075004530 Walker A/P-loop; other site 1207075004531 ATP binding site [chemical binding]; other site 1207075004532 Q-loop/lid; other site 1207075004533 ABC transporter signature motif; other site 1207075004534 Walker B; other site 1207075004535 D-loop; other site 1207075004536 H-loop/switch region; other site 1207075004537 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 1207075004538 PAS domain S-box; Region: sensory_box; TIGR00229 1207075004539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075004540 putative active site [active] 1207075004541 heme pocket [chemical binding]; other site 1207075004542 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075004543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075004544 metal binding site [ion binding]; metal-binding site 1207075004545 active site 1207075004546 I-site; other site 1207075004547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075004548 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1207075004549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075004550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075004551 metal binding site [ion binding]; metal-binding site 1207075004552 active site 1207075004553 I-site; other site 1207075004554 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1207075004555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075004556 NAD(P) binding site [chemical binding]; other site 1207075004557 active site 1207075004558 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1207075004559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075004560 motif II; other site 1207075004561 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1207075004562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075004563 S-adenosylmethionine binding site [chemical binding]; other site 1207075004564 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1207075004565 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1207075004566 active site 1207075004567 putative substrate binding pocket [chemical binding]; other site 1207075004568 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1207075004569 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1207075004570 DNA gyrase subunit A; Validated; Region: PRK05560 1207075004571 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1207075004572 CAP-like domain; other site 1207075004573 active site 1207075004574 primary dimer interface [polypeptide binding]; other site 1207075004575 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1207075004576 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1207075004577 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1207075004578 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1207075004579 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1207075004580 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1207075004581 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1207075004582 homodimer interface [polypeptide binding]; other site 1207075004583 substrate-cofactor binding pocket; other site 1207075004584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075004585 catalytic residue [active] 1207075004586 Chorismate mutase type II; Region: CM_2; cl00693 1207075004587 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1207075004588 Prephenate dehydratase; Region: PDT; pfam00800 1207075004589 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1207075004590 putative L-Phe binding site [chemical binding]; other site 1207075004591 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1207075004592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075004593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075004594 homodimer interface [polypeptide binding]; other site 1207075004595 catalytic residue [active] 1207075004596 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1207075004597 prephenate dehydrogenase; Validated; Region: PRK08507 1207075004598 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1207075004599 hinge; other site 1207075004600 active site 1207075004601 cytidylate kinase; Provisional; Region: cmk; PRK00023 1207075004602 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1207075004603 CMP-binding site; other site 1207075004604 The sites determining sugar specificity; other site 1207075004605 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1207075004606 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1207075004607 RNA binding site [nucleotide binding]; other site 1207075004608 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1207075004609 RNA binding site [nucleotide binding]; other site 1207075004610 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1207075004611 RNA binding site [nucleotide binding]; other site 1207075004612 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1207075004613 RNA binding site [nucleotide binding]; other site 1207075004614 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1207075004615 RNA binding site [nucleotide binding]; other site 1207075004616 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1207075004617 RNA binding site [nucleotide binding]; other site 1207075004618 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1207075004619 IHF dimer interface [polypeptide binding]; other site 1207075004620 IHF - DNA interface [nucleotide binding]; other site 1207075004621 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1207075004622 Chain length determinant protein; Region: Wzz; cl15801 1207075004623 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1207075004624 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1207075004625 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1207075004626 trimer interface [polypeptide binding]; other site 1207075004627 active site 1207075004628 substrate binding site [chemical binding]; other site 1207075004629 CoA binding site [chemical binding]; other site 1207075004630 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1207075004631 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1207075004632 inhibitor-cofactor binding pocket; inhibition site 1207075004633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075004634 catalytic residue [active] 1207075004635 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1207075004636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075004637 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1207075004638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075004639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1207075004640 putative glycosyl transferase; Provisional; Region: PRK10307 1207075004641 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1207075004642 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1207075004643 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1207075004644 NADP binding site [chemical binding]; other site 1207075004645 active site 1207075004646 putative substrate binding site [chemical binding]; other site 1207075004647 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1207075004648 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1207075004649 NAD(P) binding site [chemical binding]; other site 1207075004650 homodimer interface [polypeptide binding]; other site 1207075004651 substrate binding site [chemical binding]; other site 1207075004652 active site 1207075004653 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1207075004654 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1207075004655 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1207075004656 active site 1207075004657 homodimer interface [polypeptide binding]; other site 1207075004658 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075004659 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1207075004660 putative NAD(P) binding site [chemical binding]; other site 1207075004661 active site 1207075004662 putative substrate binding site [chemical binding]; other site 1207075004663 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1207075004664 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1207075004665 Mg++ binding site [ion binding]; other site 1207075004666 putative catalytic motif [active] 1207075004667 putative substrate binding site [chemical binding]; other site 1207075004668 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1207075004669 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1207075004670 NAD(P) binding site [chemical binding]; other site 1207075004671 homodimer interface [polypeptide binding]; other site 1207075004672 substrate binding site [chemical binding]; other site 1207075004673 active site 1207075004674 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1207075004675 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1207075004676 classical (c) SDRs; Region: SDR_c; cd05233 1207075004677 NAD(P) binding site [chemical binding]; other site 1207075004678 active site 1207075004679 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1207075004680 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1207075004681 dimer interface [polypeptide binding]; other site 1207075004682 active site 1207075004683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075004684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075004685 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1207075004686 ethanolamine permease; Region: 2A0305; TIGR00908 1207075004687 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1207075004688 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1207075004689 NADP binding site [chemical binding]; other site 1207075004690 active site 1207075004691 putative substrate binding site [chemical binding]; other site 1207075004692 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1207075004693 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1207075004694 substrate binding site; other site 1207075004695 tetramer interface; other site 1207075004696 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1207075004697 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1207075004698 NAD binding site [chemical binding]; other site 1207075004699 substrate binding site [chemical binding]; other site 1207075004700 homodimer interface [polypeptide binding]; other site 1207075004701 active site 1207075004702 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1207075004703 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1207075004704 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1207075004705 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1207075004706 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1207075004707 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1207075004708 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1207075004709 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1207075004710 Ligand Binding Site [chemical binding]; other site 1207075004711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075004712 dimer interface [polypeptide binding]; other site 1207075004713 phosphorylation site [posttranslational modification] 1207075004714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075004715 ATP binding site [chemical binding]; other site 1207075004716 Mg2+ binding site [ion binding]; other site 1207075004717 G-X-G motif; other site 1207075004718 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1207075004719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004720 active site 1207075004721 phosphorylation site [posttranslational modification] 1207075004722 intermolecular recognition site; other site 1207075004723 dimerization interface [polypeptide binding]; other site 1207075004724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075004725 DNA binding site [nucleotide binding] 1207075004726 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1207075004727 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1207075004728 active site 1207075004729 nucleophile elbow; other site 1207075004730 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1207075004731 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1207075004732 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1207075004733 active site 1207075004734 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1207075004735 active site 2 [active] 1207075004736 active site 1 [active] 1207075004737 Protein of unknown function (DUF962); Region: DUF962; cl01879 1207075004738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075004739 dimerization interface [polypeptide binding]; other site 1207075004740 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075004741 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075004742 dimer interface [polypeptide binding]; other site 1207075004743 putative CheW interface [polypeptide binding]; other site 1207075004744 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1207075004745 active site 1207075004746 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1207075004747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075004748 substrate binding pocket [chemical binding]; other site 1207075004749 membrane-bound complex binding site; other site 1207075004750 hinge residues; other site 1207075004751 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075004752 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075004753 catalytic residue [active] 1207075004754 Predicted membrane protein [Function unknown]; Region: COG2259 1207075004755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075004756 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1207075004757 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1207075004758 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1207075004759 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1207075004760 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1207075004761 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1207075004762 Walker A/P-loop; other site 1207075004763 ATP binding site [chemical binding]; other site 1207075004764 Q-loop/lid; other site 1207075004765 ABC transporter signature motif; other site 1207075004766 Walker B; other site 1207075004767 D-loop; other site 1207075004768 H-loop/switch region; other site 1207075004769 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1207075004770 active site 1207075004771 catalytic triad [active] 1207075004772 oxyanion hole [active] 1207075004773 switch loop; other site 1207075004774 L,D-transpeptidase; Provisional; Region: PRK10260 1207075004775 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1207075004776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075004777 Coenzyme A binding pocket [chemical binding]; other site 1207075004778 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1207075004779 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1207075004780 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1207075004781 catalytic residues [active] 1207075004782 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1207075004783 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1207075004784 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1207075004785 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1207075004786 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075004787 Ligand Binding Site [chemical binding]; other site 1207075004788 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1207075004789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075004790 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1207075004791 substrate binding site [chemical binding]; other site 1207075004792 dimerization interface [polypeptide binding]; other site 1207075004793 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1207075004794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1207075004795 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1207075004796 elongation factor P; Validated; Region: PRK00529 1207075004797 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1207075004798 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1207075004799 RNA binding site [nucleotide binding]; other site 1207075004800 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1207075004801 RNA binding site [nucleotide binding]; other site 1207075004802 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1207075004803 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075004804 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1207075004805 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1207075004806 MarR family; Region: MarR; pfam01047 1207075004807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075004808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075004809 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075004810 putative effector binding pocket; other site 1207075004811 dimerization interface [polypeptide binding]; other site 1207075004812 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075004813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075004814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075004815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075004816 dimerization interface [polypeptide binding]; other site 1207075004817 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1207075004818 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1207075004819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1207075004820 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1207075004821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075004822 enoyl-CoA hydratase; Provisional; Region: PRK06563 1207075004823 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075004824 substrate binding site [chemical binding]; other site 1207075004825 oxyanion hole (OAH) forming residues; other site 1207075004826 trimer interface [polypeptide binding]; other site 1207075004827 helicase 45; Provisional; Region: PTZ00424 1207075004828 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1207075004829 ATP binding site [chemical binding]; other site 1207075004830 Mg++ binding site [ion binding]; other site 1207075004831 motif III; other site 1207075004832 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075004833 nucleotide binding region [chemical binding]; other site 1207075004834 ATP-binding site [chemical binding]; other site 1207075004835 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1207075004836 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1207075004837 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1207075004838 putative active site [active] 1207075004839 metal binding site [ion binding]; metal-binding site 1207075004840 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1207075004841 heat shock protein HtpX; Provisional; Region: PRK05457 1207075004842 aminotransferase AlaT; Validated; Region: PRK09265 1207075004843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075004844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075004845 homodimer interface [polypeptide binding]; other site 1207075004846 catalytic residue [active] 1207075004847 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1207075004848 SelR domain; Region: SelR; pfam01641 1207075004849 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1207075004850 catalytic residues [active] 1207075004851 dimer interface [polypeptide binding]; other site 1207075004852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1207075004853 MarR family; Region: MarR; pfam01047 1207075004854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075004855 dimer interface [polypeptide binding]; other site 1207075004856 phosphorylation site [posttranslational modification] 1207075004857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075004858 ATP binding site [chemical binding]; other site 1207075004859 Mg2+ binding site [ion binding]; other site 1207075004860 G-X-G motif; other site 1207075004861 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075004862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004863 active site 1207075004864 phosphorylation site [posttranslational modification] 1207075004865 intermolecular recognition site; other site 1207075004866 dimerization interface [polypeptide binding]; other site 1207075004867 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1207075004868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075004869 Walker A motif; other site 1207075004870 ATP binding site [chemical binding]; other site 1207075004871 Walker B motif; other site 1207075004872 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1207075004873 GAF domain; Region: GAF_2; pfam13185 1207075004874 HAMP domain; Region: HAMP; pfam00672 1207075004875 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1207075004876 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1207075004877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075004878 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1207075004879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075004880 substrate binding pocket [chemical binding]; other site 1207075004881 membrane-bound complex binding site; other site 1207075004882 hinge residues; other site 1207075004883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075004884 substrate binding pocket [chemical binding]; other site 1207075004885 membrane-bound complex binding site; other site 1207075004886 hinge residues; other site 1207075004887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075004888 putative active site [active] 1207075004889 heme pocket [chemical binding]; other site 1207075004890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075004891 dimer interface [polypeptide binding]; other site 1207075004892 phosphorylation site [posttranslational modification] 1207075004893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075004894 ATP binding site [chemical binding]; other site 1207075004895 Mg2+ binding site [ion binding]; other site 1207075004896 G-X-G motif; other site 1207075004897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004898 active site 1207075004899 phosphorylation site [posttranslational modification] 1207075004900 intermolecular recognition site; other site 1207075004901 dimerization interface [polypeptide binding]; other site 1207075004902 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075004903 putative binding surface; other site 1207075004904 active site 1207075004905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075004906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004907 active site 1207075004908 phosphorylation site [posttranslational modification] 1207075004909 intermolecular recognition site; other site 1207075004910 dimerization interface [polypeptide binding]; other site 1207075004911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075004912 DNA binding residues [nucleotide binding] 1207075004913 dimerization interface [polypeptide binding]; other site 1207075004914 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075004915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004916 active site 1207075004917 phosphorylation site [posttranslational modification] 1207075004918 intermolecular recognition site; other site 1207075004919 dimerization interface [polypeptide binding]; other site 1207075004920 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1207075004921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075004922 Zn2+ binding site [ion binding]; other site 1207075004923 Mg2+ binding site [ion binding]; other site 1207075004924 Predicted membrane protein [Function unknown]; Region: COG5393 1207075004925 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1207075004926 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1207075004927 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1207075004928 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1207075004929 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1207075004930 probable active site [active] 1207075004931 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1207075004932 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1207075004933 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1207075004934 GTP binding site; other site 1207075004935 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1207075004936 MPT binding site; other site 1207075004937 trimer interface [polypeptide binding]; other site 1207075004938 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1207075004939 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1207075004940 dimer interface [polypeptide binding]; other site 1207075004941 putative functional site; other site 1207075004942 putative MPT binding site; other site 1207075004943 lipid kinase; Reviewed; Region: PRK13054 1207075004944 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1207075004945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075004946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004947 active site 1207075004948 phosphorylation site [posttranslational modification] 1207075004949 intermolecular recognition site; other site 1207075004950 dimerization interface [polypeptide binding]; other site 1207075004951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075004952 DNA binding residues [nucleotide binding] 1207075004953 dimerization interface [polypeptide binding]; other site 1207075004954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1207075004955 Histidine kinase; Region: HisKA_3; pfam07730 1207075004956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075004957 ATP binding site [chemical binding]; other site 1207075004958 Mg2+ binding site [ion binding]; other site 1207075004959 G-X-G motif; other site 1207075004960 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1207075004961 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075004962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075004963 active site 1207075004964 phosphorylation site [posttranslational modification] 1207075004965 intermolecular recognition site; other site 1207075004966 dimerization interface [polypeptide binding]; other site 1207075004967 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1207075004968 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1207075004969 MOSC domain; Region: MOSC; pfam03473 1207075004970 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1207075004971 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1207075004972 active site 1207075004973 catalytic site [active] 1207075004974 substrate binding site [chemical binding]; other site 1207075004975 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1207075004976 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075004977 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1207075004978 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1207075004979 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1207075004980 carboxyltransferase (CT) interaction site; other site 1207075004981 biotinylation site [posttranslational modification]; other site 1207075004982 enoyl-CoA hydratase; Provisional; Region: PRK05995 1207075004983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075004984 substrate binding site [chemical binding]; other site 1207075004985 oxyanion hole (OAH) forming residues; other site 1207075004986 trimer interface [polypeptide binding]; other site 1207075004987 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075004988 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075004989 active site 1207075004990 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1207075004991 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1207075004992 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1207075004993 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1207075004994 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1207075004995 NAD(P) binding site [chemical binding]; other site 1207075004996 substrate binding site [chemical binding]; other site 1207075004997 homotetramer interface [polypeptide binding]; other site 1207075004998 active site 1207075004999 homodimer interface [polypeptide binding]; other site 1207075005000 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1207075005001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075005002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075005003 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1207075005004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075005005 substrate binding pocket [chemical binding]; other site 1207075005006 membrane-bound complex binding site; other site 1207075005007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1207075005008 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1207075005009 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1207075005010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075005011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075005012 DNA binding residues [nucleotide binding] 1207075005013 peptide synthase; Validated; Region: PRK05691 1207075005014 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1207075005015 acyl-activating enzyme (AAE) consensus motif; other site 1207075005016 active site 1207075005017 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005018 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005019 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005020 acyl-activating enzyme (AAE) consensus motif; other site 1207075005021 AMP binding site [chemical binding]; other site 1207075005022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005023 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005025 acyl-activating enzyme (AAE) consensus motif; other site 1207075005026 AMP binding site [chemical binding]; other site 1207075005027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005028 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1207075005029 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005031 acyl-activating enzyme (AAE) consensus motif; other site 1207075005032 AMP binding site [chemical binding]; other site 1207075005033 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005034 Fibronectin type 3 domain; Region: FN3; smart00060 1207075005035 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1207075005036 Interdomain contacts; other site 1207075005037 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1207075005038 Interdomain contacts; other site 1207075005039 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1207075005040 Interdomain contacts; other site 1207075005041 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1207075005042 nucleic acid binding site [nucleotide binding]; other site 1207075005043 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1207075005044 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1207075005045 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1207075005046 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1207075005047 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1207075005048 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1207075005049 dimerization domain [polypeptide binding]; other site 1207075005050 dimer interface [polypeptide binding]; other site 1207075005051 catalytic residues [active] 1207075005052 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1207075005053 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1207075005054 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1207075005055 catalytic residues [active] 1207075005056 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1207075005057 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1207075005058 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1207075005059 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1207075005060 DsbD alpha interface [polypeptide binding]; other site 1207075005061 catalytic residues [active] 1207075005062 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1207075005063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075005064 active site 1207075005065 phosphorylation site [posttranslational modification] 1207075005066 intermolecular recognition site; other site 1207075005067 dimerization interface [polypeptide binding]; other site 1207075005068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075005069 DNA binding site [nucleotide binding] 1207075005070 sensor protein QseC; Provisional; Region: PRK10337 1207075005071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075005072 dimer interface [polypeptide binding]; other site 1207075005073 phosphorylation site [posttranslational modification] 1207075005074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075005075 ATP binding site [chemical binding]; other site 1207075005076 G-X-G motif; other site 1207075005077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075005078 Transposase; Region: HTH_Tnp_1; pfam01527 1207075005079 putative transposase OrfB; Reviewed; Region: PHA02517 1207075005080 HTH-like domain; Region: HTH_21; pfam13276 1207075005081 Integrase core domain; Region: rve; pfam00665 1207075005082 Integrase core domain; Region: rve_3; pfam13683 1207075005083 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1207075005084 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075005085 inhibitor-cofactor binding pocket; inhibition site 1207075005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075005087 catalytic residue [active] 1207075005088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1207075005089 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1207075005090 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1207075005091 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1207075005092 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1207075005093 ABC-ATPase subunit interface; other site 1207075005094 dimer interface [polypeptide binding]; other site 1207075005095 putative PBP binding regions; other site 1207075005096 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1207075005097 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1207075005098 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1207075005099 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1207075005100 metal binding site [ion binding]; metal-binding site 1207075005101 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1207075005102 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1207075005103 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1207075005104 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1207075005105 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1207075005106 putative dimer interface [polypeptide binding]; other site 1207075005107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075005108 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075005109 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1207075005110 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1207075005111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075005112 catalytic residue [active] 1207075005113 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1207075005114 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1207075005115 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1207075005116 active site 1207075005117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075005118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005119 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075005120 putative effector binding pocket; other site 1207075005121 dimerization interface [polypeptide binding]; other site 1207075005122 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1207075005123 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1207075005124 putative NAD(P) binding site [chemical binding]; other site 1207075005125 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1207075005126 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1207075005127 putative catalytic residue [active] 1207075005128 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1207075005129 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1207075005130 putative NAD(P) binding site [chemical binding]; other site 1207075005131 active site 1207075005132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075005133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075005134 threonine and homoserine efflux system; Provisional; Region: PRK10532 1207075005135 EamA-like transporter family; Region: EamA; pfam00892 1207075005136 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1207075005137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1207075005138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1207075005139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075005140 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1207075005141 putative ADP-binding pocket [chemical binding]; other site 1207075005142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075005143 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1207075005144 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1207075005145 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1207075005146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075005147 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1207075005148 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1207075005149 Walker A/P-loop; other site 1207075005150 ATP binding site [chemical binding]; other site 1207075005151 Q-loop/lid; other site 1207075005152 ABC transporter signature motif; other site 1207075005153 Walker B; other site 1207075005154 D-loop; other site 1207075005155 H-loop/switch region; other site 1207075005156 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1207075005157 putative carbohydrate binding site [chemical binding]; other site 1207075005158 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1207075005159 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1207075005160 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1207075005161 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1207075005162 Substrate binding site; other site 1207075005163 Cupin domain; Region: Cupin_2; cl17218 1207075005164 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1207075005165 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1207075005166 NADP-binding site; other site 1207075005167 homotetramer interface [polypeptide binding]; other site 1207075005168 substrate binding site [chemical binding]; other site 1207075005169 homodimer interface [polypeptide binding]; other site 1207075005170 active site 1207075005171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075005172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075005173 NAD(P) binding site [chemical binding]; other site 1207075005174 active site 1207075005175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075005176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1207075005177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075005178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1207075005179 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1207075005180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075005181 S-adenosylmethionine binding site [chemical binding]; other site 1207075005182 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1207075005183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075005184 S-adenosylmethionine binding site [chemical binding]; other site 1207075005185 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1207075005186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1207075005187 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1207075005188 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1207075005189 putative hydrophobic ligand binding site [chemical binding]; other site 1207075005190 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1207075005191 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1207075005192 conserved cys residue [active] 1207075005193 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075005194 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075005195 conserved cys residue [active] 1207075005196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075005197 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1207075005198 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1207075005199 Condensation domain; Region: Condensation; pfam00668 1207075005200 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005201 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005202 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005203 acyl-activating enzyme (AAE) consensus motif; other site 1207075005204 AMP binding site [chemical binding]; other site 1207075005205 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005206 Condensation domain; Region: Condensation; pfam00668 1207075005207 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005208 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1207075005209 Condensation domain; Region: Condensation; pfam00668 1207075005210 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005211 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005212 acyl-activating enzyme (AAE) consensus motif; other site 1207075005213 AMP binding site [chemical binding]; other site 1207075005214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005215 Condensation domain; Region: Condensation; pfam00668 1207075005216 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005217 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005218 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1207075005219 Condensation domain; Region: Condensation; pfam00668 1207075005220 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005221 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1207075005222 acyl-activating enzyme (AAE) consensus motif; other site 1207075005223 AMP binding site [chemical binding]; other site 1207075005224 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005225 Condensation domain; Region: Condensation; pfam00668 1207075005226 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005227 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005228 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005229 acyl-activating enzyme (AAE) consensus motif; other site 1207075005230 AMP binding site [chemical binding]; other site 1207075005231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005232 Condensation domain; Region: Condensation; pfam00668 1207075005233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005234 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1207075005235 Condensation domain; Region: Condensation; pfam00668 1207075005236 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1207075005237 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1207075005238 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005239 acyl-activating enzyme (AAE) consensus motif; other site 1207075005240 AMP binding site [chemical binding]; other site 1207075005241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005242 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1207075005243 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1207075005244 acyl-activating enzyme (AAE) consensus motif; other site 1207075005245 AMP binding site [chemical binding]; other site 1207075005246 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1207075005247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1207075005248 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1207075005249 substrate binding pocket [chemical binding]; other site 1207075005250 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1207075005251 active site 1207075005252 DNA binding site [nucleotide binding] 1207075005253 Int/Topo IB signature motif; other site 1207075005254 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075005255 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075005256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1207075005257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075005258 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1207075005259 NAD(P) binding site [chemical binding]; other site 1207075005260 active site 1207075005261 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1207075005262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1207075005263 DNA binding residues [nucleotide binding] 1207075005264 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1207075005265 dimer interface [polypeptide binding]; other site 1207075005266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075005267 ligand binding site [chemical binding]; other site 1207075005268 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075005269 CoenzymeA binding site [chemical binding]; other site 1207075005270 subunit interaction site [polypeptide binding]; other site 1207075005271 PHB binding site; other site 1207075005272 Cache domain; Region: Cache_1; pfam02743 1207075005273 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075005274 metal binding site [ion binding]; metal-binding site 1207075005275 active site 1207075005276 I-site; other site 1207075005277 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075005278 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1207075005279 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075005280 N-terminal plug; other site 1207075005281 ligand-binding site [chemical binding]; other site 1207075005282 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1207075005283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075005284 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1207075005285 Walker A/P-loop; other site 1207075005286 ATP binding site [chemical binding]; other site 1207075005287 Q-loop/lid; other site 1207075005288 ABC transporter signature motif; other site 1207075005289 Walker B; other site 1207075005290 D-loop; other site 1207075005291 H-loop/switch region; other site 1207075005292 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1207075005293 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1207075005294 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1207075005295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1207075005296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075005297 catalytic residue [active] 1207075005298 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1207075005299 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1207075005300 active site 1207075005301 dimer interface [polypeptide binding]; other site 1207075005302 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1207075005303 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1207075005304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1207075005305 Walker A/P-loop; other site 1207075005306 ATP binding site [chemical binding]; other site 1207075005307 Q-loop/lid; other site 1207075005308 ABC transporter signature motif; other site 1207075005309 Walker B; other site 1207075005310 D-loop; other site 1207075005311 H-loop/switch region; other site 1207075005312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1207075005313 FtsX-like permease family; Region: FtsX; pfam02687 1207075005314 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1207075005315 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075005316 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1207075005317 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075005318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075005319 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1207075005320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075005321 DNA binding residues [nucleotide binding] 1207075005322 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1207075005323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075005324 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1207075005325 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1207075005326 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1207075005327 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1207075005328 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1207075005329 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1207075005330 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1207075005331 MgtC family; Region: MgtC; pfam02308 1207075005332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075005333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075005334 active site 1207075005335 phosphorylation site [posttranslational modification] 1207075005336 intermolecular recognition site; other site 1207075005337 dimerization interface [polypeptide binding]; other site 1207075005338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075005339 DNA binding residues [nucleotide binding] 1207075005340 dimerization interface [polypeptide binding]; other site 1207075005341 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075005342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075005343 substrate binding pocket [chemical binding]; other site 1207075005344 membrane-bound complex binding site; other site 1207075005345 hinge residues; other site 1207075005346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075005347 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075005348 substrate binding pocket [chemical binding]; other site 1207075005349 membrane-bound complex binding site; other site 1207075005350 hinge residues; other site 1207075005351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075005352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075005353 dimer interface [polypeptide binding]; other site 1207075005354 phosphorylation site [posttranslational modification] 1207075005355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075005356 ATP binding site [chemical binding]; other site 1207075005357 Mg2+ binding site [ion binding]; other site 1207075005358 G-X-G motif; other site 1207075005359 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075005360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075005361 active site 1207075005362 phosphorylation site [posttranslational modification] 1207075005363 intermolecular recognition site; other site 1207075005364 dimerization interface [polypeptide binding]; other site 1207075005365 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075005366 putative binding surface; other site 1207075005367 active site 1207075005368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075005369 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075005370 active site 1207075005371 catalytic tetrad [active] 1207075005372 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075005373 CoenzymeA binding site [chemical binding]; other site 1207075005374 subunit interaction site [polypeptide binding]; other site 1207075005375 PHB binding site; other site 1207075005376 LysR family transcriptional regulator; Provisional; Region: PRK14997 1207075005377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005378 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1207075005379 putative effector binding pocket; other site 1207075005380 putative dimerization interface [polypeptide binding]; other site 1207075005381 Pirin-related protein [General function prediction only]; Region: COG1741 1207075005382 Pirin; Region: Pirin; pfam02678 1207075005383 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1207075005384 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075005385 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1207075005386 catalytic triad [active] 1207075005387 dimer interface [polypeptide binding]; other site 1207075005388 conserved cis-peptide bond; other site 1207075005389 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075005390 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1207075005391 catalytic triad [active] 1207075005392 dimer interface [polypeptide binding]; other site 1207075005393 conserved cis-peptide bond; other site 1207075005394 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1207075005395 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075005396 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1207075005397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075005398 ligand binding site [chemical binding]; other site 1207075005399 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1207075005400 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1207075005401 Viral enhancin protein; Region: Enhancin; pfam03272 1207075005402 Peptidase M60-like family; Region: M60-like; pfam13402 1207075005403 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1207075005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005405 putative substrate translocation pore; other site 1207075005406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005407 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1207075005408 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075005409 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075005410 beta-ketothiolase; Provisional; Region: PRK09051 1207075005411 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075005412 dimer interface [polypeptide binding]; other site 1207075005413 active site 1207075005414 enoyl-CoA hydratase; Provisional; Region: PRK06688 1207075005415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075005416 substrate binding site [chemical binding]; other site 1207075005417 oxyanion hole (OAH) forming residues; other site 1207075005418 trimer interface [polypeptide binding]; other site 1207075005419 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075005420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075005421 hypothetical protein; Provisional; Region: PRK07036 1207075005422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075005423 inhibitor-cofactor binding pocket; inhibition site 1207075005424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075005425 catalytic residue [active] 1207075005426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075005427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075005428 DNA binding residues [nucleotide binding] 1207075005429 dimerization interface [polypeptide binding]; other site 1207075005430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075005432 putative substrate translocation pore; other site 1207075005433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075005434 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1207075005435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075005436 DNA binding residues [nucleotide binding] 1207075005437 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1207075005438 FecR protein; Region: FecR; pfam04773 1207075005439 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075005440 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1207075005441 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075005442 N-terminal plug; other site 1207075005443 ligand-binding site [chemical binding]; other site 1207075005444 diaminopimelate epimerase; Provisional; Region: PRK13577 1207075005445 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1207075005446 cytosine deaminase; Provisional; Region: PRK09230 1207075005447 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1207075005448 active site 1207075005449 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075005450 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1207075005451 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1207075005452 active site 1207075005453 Predicted membrane protein [Function unknown]; Region: COG3212 1207075005454 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1207075005455 Predicted membrane protein [Function unknown]; Region: COG3212 1207075005456 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1207075005457 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1207075005458 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075005459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075005460 active site 1207075005461 phosphorylation site [posttranslational modification] 1207075005462 intermolecular recognition site; other site 1207075005463 dimerization interface [polypeptide binding]; other site 1207075005464 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075005465 DNA binding site [nucleotide binding] 1207075005466 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1207075005467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075005468 ATP binding site [chemical binding]; other site 1207075005469 G-X-G motif; other site 1207075005470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005471 putative substrate translocation pore; other site 1207075005472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075005473 dimerization interface [polypeptide binding]; other site 1207075005474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075005475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075005476 dimer interface [polypeptide binding]; other site 1207075005477 putative CheW interface [polypeptide binding]; other site 1207075005478 Predicted permease [General function prediction only]; Region: COG2056 1207075005479 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1207075005480 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1207075005481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075005482 dimerization interface [polypeptide binding]; other site 1207075005483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075005484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075005485 dimer interface [polypeptide binding]; other site 1207075005486 putative CheW interface [polypeptide binding]; other site 1207075005487 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1207075005488 selenophosphate synthetase; Provisional; Region: PRK00943 1207075005489 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1207075005490 dimerization interface [polypeptide binding]; other site 1207075005491 putative ATP binding site [chemical binding]; other site 1207075005492 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1207075005493 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1207075005494 active site residue [active] 1207075005495 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1207075005496 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075005497 C-terminal domain interface [polypeptide binding]; other site 1207075005498 GSH binding site (G-site) [chemical binding]; other site 1207075005499 dimer interface [polypeptide binding]; other site 1207075005500 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1207075005501 dimer interface [polypeptide binding]; other site 1207075005502 N-terminal domain interface [polypeptide binding]; other site 1207075005503 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1207075005504 dimer interface [polypeptide binding]; other site 1207075005505 active site 1207075005506 Schiff base residues; other site 1207075005507 hypothetical protein; Provisional; Region: PRK06184 1207075005508 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1207075005509 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1207075005510 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075005511 N-terminal plug; other site 1207075005512 ligand-binding site [chemical binding]; other site 1207075005513 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1207075005514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075005515 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1207075005516 C-terminal domain interface [polypeptide binding]; other site 1207075005517 GSH binding site (G-site) [chemical binding]; other site 1207075005518 dimer interface [polypeptide binding]; other site 1207075005519 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1207075005520 dimer interface [polypeptide binding]; other site 1207075005521 N-terminal domain interface [polypeptide binding]; other site 1207075005522 substrate binding pocket (H-site) [chemical binding]; other site 1207075005523 FOG: CBS domain [General function prediction only]; Region: COG0517 1207075005524 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1207075005525 DNA polymerase II; Reviewed; Region: PRK05762 1207075005526 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1207075005527 active site 1207075005528 catalytic site [active] 1207075005529 substrate binding site [chemical binding]; other site 1207075005530 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1207075005531 active site 1207075005532 metal-binding site 1207075005533 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1207075005534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075005535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075005536 active site 1207075005537 catalytic tetrad [active] 1207075005538 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075005539 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1207075005540 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1207075005541 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1207075005542 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1207075005543 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1207075005544 active site 1207075005545 tetramer interface [polypeptide binding]; other site 1207075005546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005547 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075005548 putative substrate translocation pore; other site 1207075005549 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075005550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075005551 DNA-binding site [nucleotide binding]; DNA binding site 1207075005552 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1207075005553 EamA-like transporter family; Region: EamA; pfam00892 1207075005554 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1207075005555 EamA-like transporter family; Region: EamA; pfam00892 1207075005556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075005557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075005559 dimerization interface [polypeptide binding]; other site 1207075005560 putative protease; Provisional; Region: PRK15452 1207075005561 Peptidase family U32; Region: Peptidase_U32; pfam01136 1207075005562 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1207075005563 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1207075005564 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1207075005565 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1207075005566 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1207075005567 shikimate binding site; other site 1207075005568 NAD(P) binding site [chemical binding]; other site 1207075005569 Cupin domain; Region: Cupin_2; cl17218 1207075005570 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1207075005571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075005572 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1207075005573 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1207075005574 active site 1207075005575 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1207075005576 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075005577 active site 1207075005578 short chain dehydrogenase; Provisional; Region: PRK07831 1207075005579 classical (c) SDRs; Region: SDR_c; cd05233 1207075005580 NAD(P) binding site [chemical binding]; other site 1207075005581 active site 1207075005582 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1207075005583 putative active site [active] 1207075005584 putative catalytic site [active] 1207075005585 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1207075005586 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075005587 dimer interface [polypeptide binding]; other site 1207075005588 active site 1207075005589 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 1207075005590 dimer interface [polypeptide binding]; other site 1207075005591 active site/substrate binding site [active] 1207075005592 SnoaL-like domain; Region: SnoaL_4; pfam13577 1207075005593 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1207075005594 hydrophobic ligand binding site; other site 1207075005595 short chain dehydrogenase; Provisional; Region: PRK07856 1207075005596 classical (c) SDRs; Region: SDR_c; cd05233 1207075005597 NAD(P) binding site [chemical binding]; other site 1207075005598 active site 1207075005599 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1207075005600 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1207075005601 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1207075005602 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1207075005603 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1207075005604 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1207075005605 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1207075005606 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1207075005607 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1207075005608 active site 1207075005609 catalytic residues [active] 1207075005610 metal binding site [ion binding]; metal-binding site 1207075005611 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1207075005612 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1207075005613 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1207075005614 ADP-ribose binding site [chemical binding]; other site 1207075005615 dimer interface [polypeptide binding]; other site 1207075005616 active site 1207075005617 nudix motif; other site 1207075005618 metal binding site [ion binding]; metal-binding site 1207075005619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075005620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075005621 DNA binding residues [nucleotide binding] 1207075005622 dimerization interface [polypeptide binding]; other site 1207075005623 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1207075005624 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1207075005625 iron-sulfur cluster [ion binding]; other site 1207075005626 [2Fe-2S] cluster binding site [ion binding]; other site 1207075005627 hypothetical protein; Provisional; Region: PRK06194 1207075005628 classical (c) SDRs; Region: SDR_c; cd05233 1207075005629 NAD(P) binding site [chemical binding]; other site 1207075005630 active site 1207075005631 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1207075005632 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1207075005633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075005634 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1207075005635 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1207075005636 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1207075005637 dimerization interface [polypeptide binding]; other site 1207075005638 active site 1207075005639 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1207075005640 Survival protein SurE; Region: SurE; pfam01975 1207075005641 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075005642 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075005643 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1207075005644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075005645 L-aspartate oxidase; Provisional; Region: PRK06175 1207075005646 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1207075005647 short chain dehydrogenase; Provisional; Region: PRK08303 1207075005648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075005649 NAD(P) binding site [chemical binding]; other site 1207075005650 active site 1207075005651 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1207075005652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075005653 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1207075005654 acyl-activating enzyme (AAE) consensus motif; other site 1207075005655 putative AMP binding site [chemical binding]; other site 1207075005656 putative active site [active] 1207075005657 putative CoA binding site [chemical binding]; other site 1207075005658 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1207075005659 classical (c) SDRs; Region: SDR_c; cd05233 1207075005660 NAD(P) binding site [chemical binding]; other site 1207075005661 active site 1207075005662 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1207075005663 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1207075005664 FAD binding pocket [chemical binding]; other site 1207075005665 FAD binding motif [chemical binding]; other site 1207075005666 phosphate binding motif [ion binding]; other site 1207075005667 beta-alpha-beta structure motif; other site 1207075005668 NAD(p) ribose binding residues [chemical binding]; other site 1207075005669 NAD binding pocket [chemical binding]; other site 1207075005670 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1207075005671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075005672 catalytic loop [active] 1207075005673 iron binding site [ion binding]; other site 1207075005674 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1207075005675 homotetramer interface [polypeptide binding]; other site 1207075005676 short chain dehydrogenase; Validated; Region: PRK07069 1207075005677 NAD binding site [chemical binding]; other site 1207075005678 homodimer interface [polypeptide binding]; other site 1207075005679 active site 1207075005680 hypothetical protein; Validated; Region: PRK07121 1207075005681 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1207075005682 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1207075005683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075005684 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1207075005685 Flavin binding site [chemical binding]; other site 1207075005686 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1207075005687 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1207075005688 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1207075005689 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1207075005690 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1207075005691 active site 1207075005692 Fe binding site [ion binding]; other site 1207075005693 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1207075005694 Coenzyme A transferase; Region: CoA_trans; cl17247 1207075005695 enoyl-CoA hydratase; Provisional; Region: PRK08290 1207075005696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075005697 substrate binding site [chemical binding]; other site 1207075005698 oxyanion hole (OAH) forming residues; other site 1207075005699 trimer interface [polypeptide binding]; other site 1207075005700 Nitronate monooxygenase; Region: NMO; pfam03060 1207075005701 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1207075005702 FMN binding site [chemical binding]; other site 1207075005703 substrate binding site [chemical binding]; other site 1207075005704 putative catalytic residue [active] 1207075005705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075005706 enoyl-CoA hydratase; Provisional; Region: PRK06495 1207075005707 substrate binding site [chemical binding]; other site 1207075005708 oxyanion hole (OAH) forming residues; other site 1207075005709 trimer interface [polypeptide binding]; other site 1207075005710 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1207075005711 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1207075005712 FAD binding site [chemical binding]; other site 1207075005713 substrate binding site [chemical binding]; other site 1207075005714 catalytic base [active] 1207075005715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075005716 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1207075005717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075005718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075005719 active site 1207075005720 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1207075005721 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075005722 dimer interface [polypeptide binding]; other site 1207075005723 active site 1207075005724 short chain dehydrogenase; Provisional; Region: PRK07791 1207075005725 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1207075005726 NAD binding site [chemical binding]; other site 1207075005727 homodimer interface [polypeptide binding]; other site 1207075005728 active site 1207075005729 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1207075005730 serine/threonine transporter SstT; Provisional; Region: PRK13628 1207075005731 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075005732 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075005733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005734 putative substrate translocation pore; other site 1207075005735 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1207075005736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005737 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1207075005738 putative dimerization interface [polypeptide binding]; other site 1207075005739 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1207075005740 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1207075005741 putative active site [active] 1207075005742 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1207075005743 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1207075005744 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1207075005745 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1207075005746 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1207075005747 homodimer interface [polypeptide binding]; other site 1207075005748 NADP binding site [chemical binding]; other site 1207075005749 substrate binding site [chemical binding]; other site 1207075005750 trigger factor; Provisional; Region: tig; PRK01490 1207075005751 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075005752 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1207075005753 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1207075005754 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1207075005755 oligomer interface [polypeptide binding]; other site 1207075005756 active site residues [active] 1207075005757 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1207075005758 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1207075005759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075005760 Walker A motif; other site 1207075005761 ATP binding site [chemical binding]; other site 1207075005762 Walker B motif; other site 1207075005763 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1207075005764 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1207075005765 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1207075005766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075005767 Walker A motif; other site 1207075005768 ATP binding site [chemical binding]; other site 1207075005769 Walker B motif; other site 1207075005770 arginine finger; other site 1207075005771 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1207075005772 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1207075005773 IHF - DNA interface [nucleotide binding]; other site 1207075005774 IHF dimer interface [polypeptide binding]; other site 1207075005775 periplasmic folding chaperone; Provisional; Region: PRK10788 1207075005776 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1207075005777 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1207075005778 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1207075005779 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075005780 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075005781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075005782 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1207075005783 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075005784 active site 1207075005785 catalytic triad [active] 1207075005786 dimer interface [polypeptide binding]; other site 1207075005787 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1207075005788 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1207075005789 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075005790 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075005791 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1207075005792 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1207075005793 Walker A/P-loop; other site 1207075005794 ATP binding site [chemical binding]; other site 1207075005795 Q-loop/lid; other site 1207075005796 ABC transporter signature motif; other site 1207075005797 Walker B; other site 1207075005798 D-loop; other site 1207075005799 H-loop/switch region; other site 1207075005800 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1207075005801 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 1207075005802 putative heme binding site [chemical binding]; other site 1207075005803 putative substrate binding site [chemical binding]; other site 1207075005804 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1207075005805 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 1207075005806 putative heme binding site [chemical binding]; other site 1207075005807 putative substrate binding site [chemical binding]; other site 1207075005808 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1207075005809 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1207075005810 putative di-iron ligands [ion binding]; other site 1207075005811 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1207075005812 PaaX-like protein; Region: PaaX; pfam07848 1207075005813 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1207075005814 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1207075005815 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1207075005816 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1207075005817 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1207075005818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1207075005819 binding surface 1207075005820 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1207075005821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075005822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005823 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075005824 dimerization interface [polypeptide binding]; other site 1207075005825 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075005826 Sulfatase; Region: Sulfatase; cl17466 1207075005827 Sulfatase; Region: Sulfatase; cl17466 1207075005828 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1207075005829 choline dehydrogenase; Validated; Region: PRK02106 1207075005830 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075005831 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075005832 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075005833 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075005834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075005836 dimerization interface [polypeptide binding]; other site 1207075005837 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1207075005838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075005839 acyl-activating enzyme (AAE) consensus motif; other site 1207075005840 active site 1207075005841 AMP binding site [chemical binding]; other site 1207075005842 CoA binding site [chemical binding]; other site 1207075005843 enoyl-CoA hydratase; Provisional; Region: PRK06563 1207075005844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075005845 substrate binding site [chemical binding]; other site 1207075005846 oxyanion hole (OAH) forming residues; other site 1207075005847 trimer interface [polypeptide binding]; other site 1207075005848 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1207075005849 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1207075005850 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1207075005851 NAD(P) binding site [chemical binding]; other site 1207075005852 catalytic residues [active] 1207075005853 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1207075005854 enoyl-CoA hydratase; Provisional; Region: PRK07658 1207075005855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075005856 substrate binding site [chemical binding]; other site 1207075005857 oxyanion hole (OAH) forming residues; other site 1207075005858 trimer interface [polypeptide binding]; other site 1207075005859 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075005860 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1207075005861 active site 1207075005862 FMN binding site [chemical binding]; other site 1207075005863 2,4-decadienoyl-CoA binding site; other site 1207075005864 catalytic residue [active] 1207075005865 4Fe-4S cluster binding site [ion binding]; other site 1207075005866 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1207075005867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075005868 D-cysteine desulfhydrase; Validated; Region: PRK03910 1207075005869 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1207075005870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075005871 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1207075005872 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1207075005873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075005874 motif II; other site 1207075005875 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1207075005876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075005877 catalytic residue [active] 1207075005878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005879 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1207075005880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075005881 dimerization interface [polypeptide binding]; other site 1207075005882 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1207075005883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075005885 dimerization interface [polypeptide binding]; other site 1207075005886 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1207075005887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075005888 putative substrate translocation pore; other site 1207075005889 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1207075005890 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1207075005891 hypothetical protein; Provisional; Region: PRK12378 1207075005892 Leucine rich repeat; Region: LRR_8; pfam13855 1207075005893 Leucine rich repeat; Region: LRR_8; pfam13855 1207075005894 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1207075005895 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1207075005896 active site 1207075005897 ATP binding site [chemical binding]; other site 1207075005898 substrate binding site [chemical binding]; other site 1207075005899 activation loop (A-loop); other site 1207075005900 Predicted ATPase [General function prediction only]; Region: COG1485 1207075005901 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1207075005902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075005903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075005904 DNA binding residues [nucleotide binding] 1207075005905 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1207075005906 putative heme binding pocket [chemical binding]; other site 1207075005907 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1207075005908 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1207075005909 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1207075005910 active site 1207075005911 Zn binding site [ion binding]; other site 1207075005912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075005913 non-specific DNA binding site [nucleotide binding]; other site 1207075005914 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1207075005915 salt bridge; other site 1207075005916 sequence-specific DNA binding site [nucleotide binding]; other site 1207075005917 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1207075005918 Catalytic site [active] 1207075005919 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1207075005920 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075005921 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1207075005922 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1207075005923 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1207075005924 carboxyltransferase (CT) interaction site; other site 1207075005925 biotinylation site [posttranslational modification]; other site 1207075005926 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1207075005927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075005928 substrate binding site [chemical binding]; other site 1207075005929 oxyanion hole (OAH) forming residues; other site 1207075005930 trimer interface [polypeptide binding]; other site 1207075005931 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1207075005932 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1207075005933 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1207075005934 isovaleryl-CoA dehydrogenase; Region: PLN02519 1207075005935 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1207075005936 substrate binding site [chemical binding]; other site 1207075005937 FAD binding site [chemical binding]; other site 1207075005938 catalytic base [active] 1207075005939 AMP-binding domain protein; Validated; Region: PRK08315 1207075005940 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075005941 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1207075005942 acyl-activating enzyme (AAE) consensus motif; other site 1207075005943 putative AMP binding site [chemical binding]; other site 1207075005944 putative active site [active] 1207075005945 putative CoA binding site [chemical binding]; other site 1207075005946 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1207075005947 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1207075005948 active site 1207075005949 catalytic residues [active] 1207075005950 metal binding site [ion binding]; metal-binding site 1207075005951 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1207075005952 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1207075005953 DNA binding residues [nucleotide binding] 1207075005954 putative dimer interface [polypeptide binding]; other site 1207075005955 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1207075005956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075005957 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1207075005958 substrate binding pocket [chemical binding]; other site 1207075005959 dimerization interface [polypeptide binding]; other site 1207075005960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075005961 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1207075005962 FAD binding site [chemical binding]; other site 1207075005963 substrate binding site [chemical binding]; other site 1207075005964 catalytic base [active] 1207075005965 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1207075005966 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075005967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075005968 ligand binding site [chemical binding]; other site 1207075005969 putative transposase OrfB; Reviewed; Region: PHA02517 1207075005970 HTH-like domain; Region: HTH_21; pfam13276 1207075005971 Integrase core domain; Region: rve; pfam00665 1207075005972 Integrase core domain; Region: rve_3; pfam13683 1207075005973 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1207075005974 putative catalytic site [active] 1207075005975 putative phosphate binding site [ion binding]; other site 1207075005976 active site 1207075005977 metal binding site A [ion binding]; metal-binding site 1207075005978 DNA binding site [nucleotide binding] 1207075005979 putative AP binding site [nucleotide binding]; other site 1207075005980 putative metal binding site B [ion binding]; other site 1207075005981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1207075005982 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1207075005983 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1207075005984 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1207075005985 Surface antigen; Region: Bac_surface_Ag; pfam01103 1207075005986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1207075005987 Family of unknown function (DUF490); Region: DUF490; pfam04357 1207075005988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1207075005989 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1207075005990 putative active site [active] 1207075005991 putative metal binding site [ion binding]; other site 1207075005992 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1207075005993 substrate binding site [chemical binding]; other site 1207075005994 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1207075005995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1207075005996 active site 1207075005997 HIGH motif; other site 1207075005998 nucleotide binding site [chemical binding]; other site 1207075005999 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1207075006000 KMSKS motif; other site 1207075006001 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1207075006002 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1207075006003 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1207075006004 active site 1207075006005 HIGH motif; other site 1207075006006 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1207075006007 KMSKS motif; other site 1207075006008 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1207075006009 tRNA binding surface [nucleotide binding]; other site 1207075006010 anticodon binding site; other site 1207075006011 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1207075006012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075006013 Walker A motif; other site 1207075006014 ATP binding site [chemical binding]; other site 1207075006015 Walker B motif; other site 1207075006016 arginine finger; other site 1207075006017 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075006018 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1207075006019 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1207075006020 Walker A/P-loop; other site 1207075006021 ATP binding site [chemical binding]; other site 1207075006022 Q-loop/lid; other site 1207075006023 ABC transporter signature motif; other site 1207075006024 Walker B; other site 1207075006025 D-loop; other site 1207075006026 H-loop/switch region; other site 1207075006027 TOBE domain; Region: TOBE_2; pfam08402 1207075006028 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1207075006029 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1207075006030 Walker A/P-loop; other site 1207075006031 ATP binding site [chemical binding]; other site 1207075006032 Q-loop/lid; other site 1207075006033 ABC transporter signature motif; other site 1207075006034 Walker B; other site 1207075006035 D-loop; other site 1207075006036 H-loop/switch region; other site 1207075006037 TOBE domain; Region: TOBE_2; pfam08402 1207075006038 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1207075006039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075006040 putative PBP binding loops; other site 1207075006041 dimer interface [polypeptide binding]; other site 1207075006042 ABC-ATPase subunit interface; other site 1207075006043 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1207075006044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075006045 dimer interface [polypeptide binding]; other site 1207075006046 conserved gate region; other site 1207075006047 putative PBP binding loops; other site 1207075006048 ABC-ATPase subunit interface; other site 1207075006049 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1207075006050 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1207075006051 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1207075006052 putative active site [active] 1207075006053 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1207075006054 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1207075006055 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1207075006056 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1207075006057 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1207075006058 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1207075006059 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1207075006060 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1207075006061 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1207075006062 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1207075006063 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1207075006064 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1207075006065 4Fe-4S binding domain; Region: Fer4; pfam00037 1207075006066 4Fe-4S binding domain; Region: Fer4; pfam00037 1207075006067 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1207075006068 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075006069 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 1207075006070 catalytic loop [active] 1207075006071 iron binding site [ion binding]; other site 1207075006072 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1207075006073 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1207075006074 [4Fe-4S] binding site [ion binding]; other site 1207075006075 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1207075006076 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1207075006077 SLBB domain; Region: SLBB; pfam10531 1207075006078 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1207075006079 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1207075006080 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1207075006081 putative dimer interface [polypeptide binding]; other site 1207075006082 [2Fe-2S] cluster binding site [ion binding]; other site 1207075006083 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1207075006084 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1207075006085 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1207075006086 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1207075006087 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1207075006088 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075006089 classical (c) SDRs; Region: SDR_c; cd05233 1207075006090 NAD(P) binding site [chemical binding]; other site 1207075006091 active site 1207075006092 hypothetical protein; Provisional; Region: PRK07505 1207075006093 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1207075006094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075006095 catalytic residue [active] 1207075006096 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1207075006097 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1207075006098 putative active site [active] 1207075006099 putative catalytic site [active] 1207075006100 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1207075006101 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1207075006102 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1207075006103 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 1207075006104 ligand binding site [chemical binding]; other site 1207075006105 NAD binding site [chemical binding]; other site 1207075006106 catalytic site [active] 1207075006107 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1207075006108 active site 1207075006109 intersubunit interface [polypeptide binding]; other site 1207075006110 Zn2+ binding site [ion binding]; other site 1207075006111 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1207075006112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075006113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075006114 homodimer interface [polypeptide binding]; other site 1207075006115 catalytic residue [active] 1207075006116 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1207075006117 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1207075006118 HIGH motif; other site 1207075006119 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1207075006120 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1207075006121 active site 1207075006122 KMSKS motif; other site 1207075006123 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1207075006124 tRNA binding surface [nucleotide binding]; other site 1207075006125 isocitrate lyase; Provisional; Region: PRK15063 1207075006126 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1207075006127 tetramer interface [polypeptide binding]; other site 1207075006128 active site 1207075006129 Mg2+/Mn2+ binding site [ion binding]; other site 1207075006130 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1207075006131 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1207075006132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075006133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006134 Coenzyme A binding pocket [chemical binding]; other site 1207075006135 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1207075006136 adenylosuccinate lyase; Provisional; Region: PRK09285 1207075006137 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1207075006138 tetramer interface [polypeptide binding]; other site 1207075006139 active site 1207075006140 putative lysogenization regulator; Reviewed; Region: PRK00218 1207075006141 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1207075006142 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1207075006143 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1207075006144 nudix motif; other site 1207075006145 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1207075006146 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1207075006147 isocitrate dehydrogenase; Validated; Region: PRK07362 1207075006148 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1207075006149 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1207075006150 DNA-binding site [nucleotide binding]; DNA binding site 1207075006151 RNA-binding motif; other site 1207075006152 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1207075006153 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1207075006154 Clp amino terminal domain; Region: Clp_N; pfam02861 1207075006155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075006156 Walker A motif; other site 1207075006157 ATP binding site [chemical binding]; other site 1207075006158 Walker B motif; other site 1207075006159 arginine finger; other site 1207075006160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075006161 Walker A motif; other site 1207075006162 ATP binding site [chemical binding]; other site 1207075006163 Walker B motif; other site 1207075006164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1207075006165 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1207075006166 rRNA binding site [nucleotide binding]; other site 1207075006167 predicted 30S ribosome binding site; other site 1207075006168 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1207075006169 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1207075006170 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1207075006171 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1207075006172 thioredoxin reductase; Provisional; Region: PRK10262 1207075006173 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075006174 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1207075006175 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1207075006176 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1207075006177 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1207075006178 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1207075006179 recombination factor protein RarA; Reviewed; Region: PRK13342 1207075006180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075006181 Walker A motif; other site 1207075006182 ATP binding site [chemical binding]; other site 1207075006183 Walker B motif; other site 1207075006184 arginine finger; other site 1207075006185 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1207075006186 camphor resistance protein CrcB; Provisional; Region: PRK14234 1207075006187 seryl-tRNA synthetase; Provisional; Region: PRK05431 1207075006188 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1207075006189 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1207075006190 dimer interface [polypeptide binding]; other site 1207075006191 active site 1207075006192 motif 1; other site 1207075006193 motif 2; other site 1207075006194 motif 3; other site 1207075006195 siroheme synthase; Provisional; Region: cysG; PRK10637 1207075006196 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1207075006197 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1207075006198 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1207075006199 active site 1207075006200 SAM binding site [chemical binding]; other site 1207075006201 homodimer interface [polypeptide binding]; other site 1207075006202 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1207075006203 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1207075006204 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1207075006205 putative dimer interface [polypeptide binding]; other site 1207075006206 N-terminal domain interface [polypeptide binding]; other site 1207075006207 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075006208 hypothetical protein; Validated; Region: PRK09071 1207075006209 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1207075006210 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1207075006211 DsrC like protein; Region: DsrC; cl01101 1207075006212 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 1207075006213 sulfur relay protein TusC; Validated; Region: PRK00211 1207075006214 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1207075006215 Predicted membrane protein [Function unknown]; Region: COG3619 1207075006216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006217 Coenzyme A binding pocket [chemical binding]; other site 1207075006218 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1207075006219 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1207075006220 dimer interface [polypeptide binding]; other site 1207075006221 ADP-ribose binding site [chemical binding]; other site 1207075006222 active site 1207075006223 nudix motif; other site 1207075006224 metal binding site [ion binding]; metal-binding site 1207075006225 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1207075006226 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1207075006227 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1207075006228 DNA binding site [nucleotide binding] 1207075006229 active site 1207075006230 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1207075006231 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1207075006232 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075006233 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1207075006234 catalytic triad [active] 1207075006235 conserved cis-peptide bond; other site 1207075006236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075006239 dimerization interface [polypeptide binding]; other site 1207075006240 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075006241 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075006242 Na binding site [ion binding]; other site 1207075006243 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075006244 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 1207075006245 putative active site [active] 1207075006246 catalytic triad [active] 1207075006247 putative dimer interface [polypeptide binding]; other site 1207075006248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075006249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075006250 DNA binding residues [nucleotide binding] 1207075006251 dimerization interface [polypeptide binding]; other site 1207075006252 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1207075006253 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1207075006254 active site 1207075006255 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1207075006256 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1207075006257 active site 1207075006258 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1207075006259 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1207075006260 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1207075006261 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075006262 Na binding site [ion binding]; other site 1207075006263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1207075006264 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1207075006265 lipoyl synthase; Provisional; Region: PRK05481 1207075006266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075006267 FeS/SAM binding site; other site 1207075006268 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1207075006269 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1207075006270 dimer interface [polypeptide binding]; other site 1207075006271 active site 1207075006272 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1207075006273 folate binding site [chemical binding]; other site 1207075006274 glycine cleavage system protein H; Provisional; Region: PRK13380 1207075006275 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1207075006276 lipoyl attachment site [posttranslational modification]; other site 1207075006277 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1207075006278 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1207075006279 putative aromatic amino acid binding site; other site 1207075006280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075006281 Walker A motif; other site 1207075006282 ATP binding site [chemical binding]; other site 1207075006283 Walker B motif; other site 1207075006284 arginine finger; other site 1207075006285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075006288 dimerization interface [polypeptide binding]; other site 1207075006289 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 1207075006290 agmatinase; Region: agmatinase; TIGR01230 1207075006291 oligomer interface [polypeptide binding]; other site 1207075006292 active site 1207075006293 Mn binding site [ion binding]; other site 1207075006294 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075006295 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075006296 NAD(P) binding site [chemical binding]; other site 1207075006297 catalytic residues [active] 1207075006298 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075006299 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075006300 choline dehydrogenase; Validated; Region: PRK02106 1207075006301 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075006302 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075006303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006304 Coenzyme A binding pocket [chemical binding]; other site 1207075006305 NIPSNAP; Region: NIPSNAP; pfam07978 1207075006306 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1207075006307 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1207075006308 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1207075006309 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1207075006310 active site 1207075006311 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1207075006312 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1207075006313 SnoaL-like domain; Region: SnoaL_2; pfam12680 1207075006314 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1207075006315 active site 1207075006316 catalytic triad [active] 1207075006317 oxyanion hole [active] 1207075006318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075006319 non-specific DNA binding site [nucleotide binding]; other site 1207075006320 salt bridge; other site 1207075006321 sequence-specific DNA binding site [nucleotide binding]; other site 1207075006322 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1207075006323 active site 1207075006324 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075006325 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1207075006326 conserved cys residue [active] 1207075006327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006329 chorismate mutase; Provisional; Region: PRK09269 1207075006330 Chorismate mutase type II; Region: CM_2; cl00693 1207075006331 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1207075006332 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1207075006333 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1207075006334 putative active site [active] 1207075006335 metal binding site [ion binding]; metal-binding site 1207075006336 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075006337 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 1207075006338 NAD(P) binding site [chemical binding]; other site 1207075006339 catalytic residues [active] 1207075006340 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075006341 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1207075006342 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075006343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075006344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075006345 DNA binding site [nucleotide binding] 1207075006346 Predicted integral membrane protein [Function unknown]; Region: COG5616 1207075006347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075006348 TPR motif; other site 1207075006349 TPR repeat; Region: TPR_11; pfam13414 1207075006350 binding surface 1207075006351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075006352 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1207075006353 active site 1207075006354 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1207075006355 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1207075006356 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075006357 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075006358 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1207075006359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075006360 RES domain; Region: RES; pfam08808 1207075006361 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1207075006362 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075006363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075006364 dimer interface [polypeptide binding]; other site 1207075006365 putative CheW interface [polypeptide binding]; other site 1207075006366 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1207075006367 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1207075006368 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075006369 active site 1207075006370 YceI-like domain; Region: YceI; pfam04264 1207075006371 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1207075006372 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075006373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006374 Coenzyme A binding pocket [chemical binding]; other site 1207075006375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1207075006376 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075006377 CoenzymeA binding site [chemical binding]; other site 1207075006378 subunit interaction site [polypeptide binding]; other site 1207075006379 PHB binding site; other site 1207075006380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075006381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075006382 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1207075006383 homodimer interface [polypeptide binding]; other site 1207075006384 homotetramer interface [polypeptide binding]; other site 1207075006385 active site pocket [active] 1207075006386 cleavage site 1207075006387 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075006388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075006389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075006390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075006391 DNA binding residues [nucleotide binding] 1207075006392 dimerization interface [polypeptide binding]; other site 1207075006393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006395 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075006396 putative effector binding pocket; other site 1207075006397 dimerization interface [polypeptide binding]; other site 1207075006398 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1207075006399 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1207075006400 active site 1207075006401 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1207075006402 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1207075006403 active site 1207075006404 metabolite-proton symporter; Region: 2A0106; TIGR00883 1207075006405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075006406 putative substrate translocation pore; other site 1207075006407 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1207075006408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075006409 S-adenosylmethionine binding site [chemical binding]; other site 1207075006410 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1207075006411 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1207075006412 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1207075006413 Moco binding site; other site 1207075006414 metal coordination site [ion binding]; other site 1207075006415 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075006417 active site 1207075006418 phosphorylation site [posttranslational modification] 1207075006419 intermolecular recognition site; other site 1207075006420 dimerization interface [polypeptide binding]; other site 1207075006421 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1207075006422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075006423 motif II; other site 1207075006424 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1207075006425 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075006426 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075006427 conserved cys residue [active] 1207075006428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006429 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1207075006430 classical (c) SDRs; Region: SDR_c; cd05233 1207075006431 NAD(P) binding site [chemical binding]; other site 1207075006432 active site 1207075006433 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1207075006434 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1207075006435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075006436 catalytic residue [active] 1207075006437 conserverd hypothetical protein; Region: TIGR02448 1207075006438 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1207075006439 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1207075006440 DinB family; Region: DinB; cl17821 1207075006441 DinB superfamily; Region: DinB_2; pfam12867 1207075006442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006444 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1207075006445 putative substrate binding pocket [chemical binding]; other site 1207075006446 putative dimerization interface [polypeptide binding]; other site 1207075006447 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1207075006448 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1207075006449 Zinc-finger double domain; Region: zf-H2C2_2; pfam13465 1207075006450 FOG: Zn-finger [General function prediction only]; Region: COG5048 1207075006451 Zinc-finger double domain; Region: zf-H2C2_2; pfam13465 1207075006452 Zinc-finger double domain; Region: zf-H2C2_2; pfam13465 1207075006453 Zinc-finger double domain; Region: zf-H2C2_2; pfam13465 1207075006454 Zinc-finger double domain; Region: zf-H2C2_2; pfam13465 1207075006455 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1207075006456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006457 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1207075006458 dimerization interface [polypeptide binding]; other site 1207075006459 substrate binding pocket [chemical binding]; other site 1207075006460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075006461 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075006462 active site 1207075006463 catalytic tetrad [active] 1207075006464 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1207075006465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075006466 NAD(P) binding site [chemical binding]; other site 1207075006467 active site 1207075006468 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1207075006469 putative hydrophobic ligand binding site [chemical binding]; other site 1207075006470 protein interface [polypeptide binding]; other site 1207075006471 gate; other site 1207075006472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075006473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075006474 dimer interface [polypeptide binding]; other site 1207075006475 phosphorylation site [posttranslational modification] 1207075006476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075006477 ATP binding site [chemical binding]; other site 1207075006478 Mg2+ binding site [ion binding]; other site 1207075006479 G-X-G motif; other site 1207075006480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075006481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075006482 active site 1207075006483 phosphorylation site [posttranslational modification] 1207075006484 intermolecular recognition site; other site 1207075006485 dimerization interface [polypeptide binding]; other site 1207075006486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075006487 DNA binding site [nucleotide binding] 1207075006488 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075006489 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1207075006490 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1207075006491 substrate binding pocket (H-site) [chemical binding]; other site 1207075006492 N-terminal domain interface [polypeptide binding]; other site 1207075006493 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1207075006494 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1207075006495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075006496 dimer interface [polypeptide binding]; other site 1207075006497 putative CheW interface [polypeptide binding]; other site 1207075006498 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1207075006499 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075006500 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1207075006501 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1207075006502 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1207075006503 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1207075006504 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1207075006505 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1207075006506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1207075006507 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1207075006508 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1207075006509 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1207075006510 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1207075006511 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1207075006512 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1207075006513 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 1207075006514 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075006515 EamA-like transporter family; Region: EamA; pfam00892 1207075006516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075006517 non-specific DNA binding site [nucleotide binding]; other site 1207075006518 salt bridge; other site 1207075006519 sequence-specific DNA binding site [nucleotide binding]; other site 1207075006520 Cupin domain; Region: Cupin_2; pfam07883 1207075006521 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075006522 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075006523 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1207075006524 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1207075006525 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1207075006526 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1207075006527 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1207075006528 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1207075006529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075006530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075006531 dimer interface [polypeptide binding]; other site 1207075006532 phosphorylation site [posttranslational modification] 1207075006533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075006534 ATP binding site [chemical binding]; other site 1207075006535 Mg2+ binding site [ion binding]; other site 1207075006536 G-X-G motif; other site 1207075006537 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1207075006538 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1207075006539 Cu(I) binding site [ion binding]; other site 1207075006540 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075006541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075006542 dimer interface [polypeptide binding]; other site 1207075006543 phosphorylation site [posttranslational modification] 1207075006544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075006545 ATP binding site [chemical binding]; other site 1207075006546 Mg2+ binding site [ion binding]; other site 1207075006547 G-X-G motif; other site 1207075006548 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075006549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075006550 active site 1207075006551 phosphorylation site [posttranslational modification] 1207075006552 intermolecular recognition site; other site 1207075006553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075006554 Walker A motif; other site 1207075006555 ATP binding site [chemical binding]; other site 1207075006556 Walker B motif; other site 1207075006557 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075006558 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075006559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075006560 S-adenosylmethionine binding site [chemical binding]; other site 1207075006561 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1207075006562 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1207075006563 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1207075006564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1207075006565 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1207075006566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1207075006567 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1207075006568 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1207075006569 putative active site [active] 1207075006570 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1207075006571 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075006572 DXD motif; other site 1207075006573 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075006574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075006575 active site 1207075006576 O-Antigen ligase; Region: Wzy_C; pfam04932 1207075006577 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1207075006578 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1207075006579 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1207075006580 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1207075006581 Chain length determinant protein; Region: Wzz; cl15801 1207075006582 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1207075006583 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1207075006584 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1207075006585 SLBB domain; Region: SLBB; pfam10531 1207075006586 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1207075006587 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1207075006588 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075006589 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1207075006590 putative NAD(P) binding site [chemical binding]; other site 1207075006591 active site 1207075006592 putative substrate binding site [chemical binding]; other site 1207075006593 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1207075006594 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1207075006595 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1207075006596 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1207075006597 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1207075006598 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075006599 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075006600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006602 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1207075006603 substrate binding pocket [chemical binding]; other site 1207075006604 dimerization interface [polypeptide binding]; other site 1207075006605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075006608 dimerization interface [polypeptide binding]; other site 1207075006609 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075006610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075006611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006612 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075006613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075006614 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075006615 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1207075006616 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075006617 dimer interface [polypeptide binding]; other site 1207075006618 active site 1207075006619 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1207075006620 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1207075006621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075006622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006623 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1207075006624 putative dimerization interface [polypeptide binding]; other site 1207075006625 NAD-dependent deacetylase; Provisional; Region: PRK05333 1207075006626 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1207075006627 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075006628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075006629 S-adenosylmethionine binding site [chemical binding]; other site 1207075006630 hypothetical protein; Provisional; Region: PRK05409 1207075006631 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 1207075006632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075006633 HAMP domain; Region: HAMP; pfam00672 1207075006634 dimerization interface [polypeptide binding]; other site 1207075006635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1207075006636 dimer interface [polypeptide binding]; other site 1207075006637 phosphorylation site [posttranslational modification] 1207075006638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075006639 ATP binding site [chemical binding]; other site 1207075006640 Mg2+ binding site [ion binding]; other site 1207075006641 G-X-G motif; other site 1207075006642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075006643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075006644 active site 1207075006645 phosphorylation site [posttranslational modification] 1207075006646 intermolecular recognition site; other site 1207075006647 dimerization interface [polypeptide binding]; other site 1207075006648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075006649 DNA binding site [nucleotide binding] 1207075006650 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1207075006651 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1207075006652 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1207075006653 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1207075006654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1207075006655 catalytic residues [active] 1207075006656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006657 Coenzyme A binding pocket [chemical binding]; other site 1207075006658 Cupin; Region: Cupin_6; pfam12852 1207075006659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075006661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006662 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1207075006663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075006664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075006665 Transposase; Region: HTH_Tnp_1; pfam01527 1207075006666 putative transposase OrfB; Reviewed; Region: PHA02517 1207075006667 HTH-like domain; Region: HTH_21; pfam13276 1207075006668 Integrase core domain; Region: rve; pfam00665 1207075006669 Integrase core domain; Region: rve_3; pfam13683 1207075006670 PAAR motif; Region: PAAR_motif; pfam05488 1207075006671 Protein of unknown function, DUF488; Region: DUF488; cl01246 1207075006672 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1207075006673 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1207075006674 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1207075006675 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1207075006676 putative metal binding site [ion binding]; other site 1207075006677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075006678 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075006679 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075006680 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1207075006681 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1207075006682 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075006683 Sulfatase; Region: Sulfatase; pfam00884 1207075006684 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 1207075006685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1207075006686 glycosylphosphatidylinositol-specific phospholipase C; Provisional; Region: PTZ00268 1207075006687 arginine decarboxylase; Provisional; Region: PRK15029 1207075006688 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1207075006689 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1207075006690 homodimer interface [polypeptide binding]; other site 1207075006691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075006692 catalytic residue [active] 1207075006693 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1207075006694 putrescine transporter; Provisional; Region: potE; PRK10655 1207075006695 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1207075006696 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1207075006697 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1207075006698 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1207075006699 Cu(I) binding site [ion binding]; other site 1207075006700 Protein of unknown function, DUF399; Region: DUF399; cl01139 1207075006701 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1207075006702 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1207075006703 Walker A/P-loop; other site 1207075006704 ATP binding site [chemical binding]; other site 1207075006705 Q-loop/lid; other site 1207075006706 ABC transporter signature motif; other site 1207075006707 Walker B; other site 1207075006708 D-loop; other site 1207075006709 H-loop/switch region; other site 1207075006710 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1207075006711 ABC-ATPase subunit interface; other site 1207075006712 dimer interface [polypeptide binding]; other site 1207075006713 putative PBP binding regions; other site 1207075006714 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1207075006715 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1207075006716 THF binding site; other site 1207075006717 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1207075006718 substrate binding site [chemical binding]; other site 1207075006719 THF binding site; other site 1207075006720 zinc-binding site [ion binding]; other site 1207075006721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075006723 S-adenosylmethionine binding site [chemical binding]; other site 1207075006724 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1207075006725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075006726 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1207075006727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075006728 Walker A/P-loop; other site 1207075006729 ATP binding site [chemical binding]; other site 1207075006730 Q-loop/lid; other site 1207075006731 ABC transporter signature motif; other site 1207075006732 Walker B; other site 1207075006733 D-loop; other site 1207075006734 H-loop/switch region; other site 1207075006735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075006736 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1207075006737 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1207075006738 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075006739 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1207075006740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075006741 dimerization interface [polypeptide binding]; other site 1207075006742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075006743 dimer interface [polypeptide binding]; other site 1207075006744 phosphorylation site [posttranslational modification] 1207075006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075006746 ATP binding site [chemical binding]; other site 1207075006747 G-X-G motif; other site 1207075006748 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1207075006749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075006750 active site 1207075006751 phosphorylation site [posttranslational modification] 1207075006752 intermolecular recognition site; other site 1207075006753 dimerization interface [polypeptide binding]; other site 1207075006754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075006755 DNA binding site [nucleotide binding] 1207075006756 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1207075006757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1207075006758 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1207075006759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1207075006760 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075006761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075006763 dimerization interface [polypeptide binding]; other site 1207075006764 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075006765 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075006766 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075006767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075006768 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1207075006769 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1207075006770 Cupin; Region: Cupin_6; pfam12852 1207075006771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006772 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075006773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006774 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1207075006775 malate:quinone oxidoreductase; Validated; Region: PRK05257 1207075006776 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1207075006777 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1207075006778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075006779 active site 1207075006780 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075006781 Sulfatase; Region: Sulfatase; pfam00884 1207075006782 classical (c) SDRs; Region: SDR_c; cd05233 1207075006783 NAD(P) binding site [chemical binding]; other site 1207075006784 active site 1207075006785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075006786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075006787 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1207075006788 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075006789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075006790 NAD(P) binding site [chemical binding]; other site 1207075006791 active site 1207075006792 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1207075006793 active site 1207075006794 catalytic site [active] 1207075006795 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1207075006796 active site 1207075006797 catalytic site [active] 1207075006798 lipid-transfer protein; Provisional; Region: PRK08256 1207075006799 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1207075006800 active site 1207075006801 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075006802 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075006803 active site 1207075006804 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1207075006805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075006806 DNA binding residues [nucleotide binding] 1207075006807 dimerization interface [polypeptide binding]; other site 1207075006808 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075006809 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075006810 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1207075006811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075006812 substrate binding site [chemical binding]; other site 1207075006813 oxyanion hole (OAH) forming residues; other site 1207075006814 trimer interface [polypeptide binding]; other site 1207075006815 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1207075006816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075006817 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1207075006818 acyl-activating enzyme (AAE) consensus motif; other site 1207075006819 acyl-activating enzyme (AAE) consensus motif; other site 1207075006820 putative AMP binding site [chemical binding]; other site 1207075006821 putative active site [active] 1207075006822 putative CoA binding site [chemical binding]; other site 1207075006823 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075006824 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1207075006825 CoenzymeA binding site [chemical binding]; other site 1207075006826 subunit interaction site [polypeptide binding]; other site 1207075006827 PHB binding site; other site 1207075006828 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1207075006829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075006830 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1207075006831 acyl-activating enzyme (AAE) consensus motif; other site 1207075006832 putative AMP binding site [chemical binding]; other site 1207075006833 putative active site [active] 1207075006834 putative CoA binding site [chemical binding]; other site 1207075006835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075006836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075006837 active site 1207075006838 lipid-transfer protein; Provisional; Region: PRK08256 1207075006839 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1207075006840 active site 1207075006841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075006842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075006843 active site 1207075006844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075006845 active site 1207075006846 enoyl-CoA hydratase; Provisional; Region: PRK09245 1207075006847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075006848 substrate binding site [chemical binding]; other site 1207075006849 oxyanion hole (OAH) forming residues; other site 1207075006850 trimer interface [polypeptide binding]; other site 1207075006851 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1207075006852 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075006853 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075006854 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1207075006855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075006856 DNA binding residues [nucleotide binding] 1207075006857 dimerization interface [polypeptide binding]; other site 1207075006858 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075006859 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1207075006860 NAD(P) binding site [chemical binding]; other site 1207075006861 catalytic residues [active] 1207075006862 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1207075006863 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1207075006864 NAD binding site [chemical binding]; other site 1207075006865 catalytic Zn binding site [ion binding]; other site 1207075006866 substrate binding site [chemical binding]; other site 1207075006867 structural Zn binding site [ion binding]; other site 1207075006868 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1207075006869 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1207075006870 FAD binding site [chemical binding]; other site 1207075006871 substrate binding site [chemical binding]; other site 1207075006872 catalytic base [active] 1207075006873 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1207075006874 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1207075006875 active site 1207075006876 MAPEG family; Region: MAPEG; pfam01124 1207075006877 Cupin; Region: Cupin_6; pfam12852 1207075006878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075006880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006881 Cupin; Region: Cupin_6; pfam12852 1207075006882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006883 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075006884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006885 Protein of unknown function, DUF417; Region: DUF417; cl01162 1207075006886 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1207075006887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075006888 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1207075006889 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1207075006890 Cache domain; Region: Cache_1; pfam02743 1207075006891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075006892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075006893 metal binding site [ion binding]; metal-binding site 1207075006894 active site 1207075006895 I-site; other site 1207075006896 BON domain; Region: BON; pfam04972 1207075006897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1207075006898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006899 Coenzyme A binding pocket [chemical binding]; other site 1207075006900 MarR family; Region: MarR; pfam01047 1207075006901 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1207075006902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006903 Coenzyme A binding pocket [chemical binding]; other site 1207075006904 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075006905 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1207075006906 conserved cys residue [active] 1207075006907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075006908 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1207075006909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075006910 PAS domain; Region: PAS_9; pfam13426 1207075006911 putative active site [active] 1207075006912 heme pocket [chemical binding]; other site 1207075006913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075006914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075006915 dimer interface [polypeptide binding]; other site 1207075006916 phosphorylation site [posttranslational modification] 1207075006917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075006918 ATP binding site [chemical binding]; other site 1207075006919 Mg2+ binding site [ion binding]; other site 1207075006920 G-X-G motif; other site 1207075006921 NIMA-related protein kinase; Provisional; Region: PTZ00266 1207075006922 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1207075006923 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1207075006924 PYR/PP interface [polypeptide binding]; other site 1207075006925 dimer interface [polypeptide binding]; other site 1207075006926 TPP binding site [chemical binding]; other site 1207075006927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1207075006928 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1207075006929 TPP-binding site [chemical binding]; other site 1207075006930 dimer interface [polypeptide binding]; other site 1207075006931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075006932 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075006933 putative substrate translocation pore; other site 1207075006934 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1207075006935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075006936 NAD(P) binding site [chemical binding]; other site 1207075006937 active site 1207075006938 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075006939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075006940 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075006941 dimerization interface [polypeptide binding]; other site 1207075006942 substrate binding pocket [chemical binding]; other site 1207075006943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075006944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075006945 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1207075006946 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075006947 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075006948 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075006949 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1207075006950 Predicted transcriptional regulators [Transcription]; Region: COG1733 1207075006951 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1207075006952 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1207075006953 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1207075006954 NADP binding site [chemical binding]; other site 1207075006955 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1207075006956 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1207075006957 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075006958 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1207075006959 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1207075006960 Walker A/P-loop; other site 1207075006961 ATP binding site [chemical binding]; other site 1207075006962 Q-loop/lid; other site 1207075006963 ABC transporter signature motif; other site 1207075006964 Walker B; other site 1207075006965 D-loop; other site 1207075006966 H-loop/switch region; other site 1207075006967 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1207075006968 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1207075006969 FtsX-like permease family; Region: FtsX; pfam02687 1207075006970 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1207075006971 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075006972 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075006973 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075006974 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1207075006975 ATP binding site [chemical binding]; other site 1207075006976 substrate interface [chemical binding]; other site 1207075006977 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075006978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075006979 S-adenosylmethionine binding site [chemical binding]; other site 1207075006980 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1207075006981 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1207075006982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075006983 FeS/SAM binding site; other site 1207075006984 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1207075006985 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1207075006986 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1207075006987 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075006988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075006989 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075006990 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1207075006991 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1207075006992 active site 1207075006993 catalytic site [active] 1207075006994 tetramer interface [polypeptide binding]; other site 1207075006995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075006996 Coenzyme A binding pocket [chemical binding]; other site 1207075006997 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1207075006998 Predicted transcriptional regulators [Transcription]; Region: COG1733 1207075006999 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1207075007000 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075007001 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1207075007002 putative active site [active] 1207075007003 catalytic triad [active] 1207075007004 putative dimer interface [polypeptide binding]; other site 1207075007005 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1207075007006 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1207075007007 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 1207075007008 Integral membrane protein TerC family; Region: TerC; cl10468 1207075007009 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075007010 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075007011 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075007012 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1207075007013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075007014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075007015 DNA binding site [nucleotide binding] 1207075007016 AAA ATPase domain; Region: AAA_16; pfam13191 1207075007017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1207075007018 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1207075007019 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1207075007020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075007021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075007022 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075007023 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1207075007024 putative active site [active] 1207075007025 putative FMN binding site [chemical binding]; other site 1207075007026 putative substrate binding site [chemical binding]; other site 1207075007027 putative catalytic residue [active] 1207075007028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075007029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075007030 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 1207075007031 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 1207075007032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075007033 putative active site [active] 1207075007034 putative metal binding site [ion binding]; other site 1207075007035 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1207075007036 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1207075007037 AMP-binding domain protein; Validated; Region: PRK07529 1207075007038 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075007039 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1207075007040 acyl-activating enzyme (AAE) consensus motif; other site 1207075007041 putative AMP binding site [chemical binding]; other site 1207075007042 putative active site [active] 1207075007043 putative CoA binding site [chemical binding]; other site 1207075007044 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1207075007045 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1207075007046 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075007047 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075007048 catalytic residue [active] 1207075007049 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1207075007050 nudix motif; other site 1207075007051 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1207075007052 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1207075007053 putative NAD(P) binding site [chemical binding]; other site 1207075007054 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075007055 TAP-like protein; Region: Abhydrolase_4; pfam08386 1207075007056 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1207075007057 classical (c) SDRs; Region: SDR_c; cd05233 1207075007058 NAD(P) binding site [chemical binding]; other site 1207075007059 active site 1207075007060 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075007061 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1207075007062 FMN binding site [chemical binding]; other site 1207075007063 active site 1207075007064 substrate binding site [chemical binding]; other site 1207075007065 catalytic residue [active] 1207075007066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075007067 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075007068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075007069 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075007070 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1207075007071 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075007072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075007073 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075007074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1207075007075 active site 1207075007076 DNA binding site [nucleotide binding] 1207075007077 Int/Topo IB signature motif; other site 1207075007078 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1207075007079 putative metal binding site [ion binding]; other site 1207075007080 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1207075007081 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1207075007082 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1207075007083 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1207075007084 ligand binding site [chemical binding]; other site 1207075007085 flexible hinge region; other site 1207075007086 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1207075007087 non-specific DNA interactions [nucleotide binding]; other site 1207075007088 DNA binding site [nucleotide binding] 1207075007089 sequence specific DNA binding site [nucleotide binding]; other site 1207075007090 putative cAMP binding site [chemical binding]; other site 1207075007091 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1207075007092 active site 1207075007093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075007094 Putative glucoamylase; Region: Glycoamylase; pfam10091 1207075007095 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1207075007096 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1207075007097 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1207075007098 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1207075007099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1207075007100 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075007101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1207075007102 active site 1207075007103 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1207075007104 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075007105 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075007106 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1207075007107 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1207075007108 CGNR zinc finger; Region: zf-CGNR; pfam11706 1207075007109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075007110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007111 active site 1207075007112 phosphorylation site [posttranslational modification] 1207075007113 intermolecular recognition site; other site 1207075007114 dimerization interface [polypeptide binding]; other site 1207075007115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075007116 DNA binding residues [nucleotide binding] 1207075007117 dimerization interface [polypeptide binding]; other site 1207075007118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1207075007119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075007120 ATP binding site [chemical binding]; other site 1207075007121 Mg2+ binding site [ion binding]; other site 1207075007122 G-X-G motif; other site 1207075007123 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1207075007124 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1207075007125 heme binding site [chemical binding]; other site 1207075007126 substrate binding site [chemical binding]; other site 1207075007127 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1207075007128 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1207075007129 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1207075007130 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1207075007131 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075007132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007133 active site 1207075007134 phosphorylation site [posttranslational modification] 1207075007135 intermolecular recognition site; other site 1207075007136 dimerization interface [polypeptide binding]; other site 1207075007137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1207075007138 Histidine kinase; Region: HisKA_3; pfam07730 1207075007139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075007140 ATP binding site [chemical binding]; other site 1207075007141 Mg2+ binding site [ion binding]; other site 1207075007142 G-X-G motif; other site 1207075007143 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1207075007144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075007145 dimerization interface [polypeptide binding]; other site 1207075007146 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1207075007147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075007148 dimerization interface [polypeptide binding]; other site 1207075007149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075007150 dimerization interface [polypeptide binding]; other site 1207075007151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075007152 dimerization interface [polypeptide binding]; other site 1207075007153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075007154 dimerization interface [polypeptide binding]; other site 1207075007155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075007156 dimerization interface [polypeptide binding]; other site 1207075007157 GAF domain; Region: GAF_2; pfam13185 1207075007158 GAF domain; Region: GAF; cl17456 1207075007159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075007160 dimer interface [polypeptide binding]; other site 1207075007161 phosphorylation site [posttranslational modification] 1207075007162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075007163 ATP binding site [chemical binding]; other site 1207075007164 Mg2+ binding site [ion binding]; other site 1207075007165 G-X-G motif; other site 1207075007166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007167 active site 1207075007168 phosphorylation site [posttranslational modification] 1207075007169 intermolecular recognition site; other site 1207075007170 dimerization interface [polypeptide binding]; other site 1207075007171 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075007172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007173 active site 1207075007174 phosphorylation site [posttranslational modification] 1207075007175 intermolecular recognition site; other site 1207075007176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007177 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075007178 active site 1207075007179 phosphorylation site [posttranslational modification] 1207075007180 intermolecular recognition site; other site 1207075007181 dimerization interface [polypeptide binding]; other site 1207075007182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075007183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007184 active site 1207075007185 phosphorylation site [posttranslational modification] 1207075007186 intermolecular recognition site; other site 1207075007187 dimerization interface [polypeptide binding]; other site 1207075007188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075007189 DNA binding residues [nucleotide binding] 1207075007190 dimerization interface [polypeptide binding]; other site 1207075007191 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1207075007192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1207075007193 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075007194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075007195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075007196 metal binding site [ion binding]; metal-binding site 1207075007197 active site 1207075007198 I-site; other site 1207075007199 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075007200 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075007201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007202 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075007203 dimerization interface [polypeptide binding]; other site 1207075007204 substrate binding pocket [chemical binding]; other site 1207075007205 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1207075007206 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1207075007207 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1207075007208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1207075007209 Transporter associated domain; Region: CorC_HlyC; smart01091 1207075007210 universal stress protein UspE; Provisional; Region: PRK11175 1207075007211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007212 Ligand Binding Site [chemical binding]; other site 1207075007213 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007214 Ligand Binding Site [chemical binding]; other site 1207075007215 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1207075007216 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1207075007217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075007218 active site 1207075007219 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 1207075007220 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1207075007221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007222 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075007223 dimerization interface [polypeptide binding]; other site 1207075007224 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1207075007225 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1207075007226 metal binding site [ion binding]; metal-binding site 1207075007227 putative dimer interface [polypeptide binding]; other site 1207075007228 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1207075007229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075007230 substrate binding pocket [chemical binding]; other site 1207075007231 membrane-bound complex binding site; other site 1207075007232 hinge residues; other site 1207075007233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1207075007235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007236 putative PBP binding loops; other site 1207075007237 dimer interface [polypeptide binding]; other site 1207075007238 ABC-ATPase subunit interface; other site 1207075007239 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075007240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007241 dimer interface [polypeptide binding]; other site 1207075007242 conserved gate region; other site 1207075007243 putative PBP binding loops; other site 1207075007244 ABC-ATPase subunit interface; other site 1207075007245 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1207075007246 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075007247 Walker A/P-loop; other site 1207075007248 ATP binding site [chemical binding]; other site 1207075007249 Q-loop/lid; other site 1207075007250 ABC transporter signature motif; other site 1207075007251 Walker B; other site 1207075007252 D-loop; other site 1207075007253 H-loop/switch region; other site 1207075007254 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075007255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075007256 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075007257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075007258 dimerization interface [polypeptide binding]; other site 1207075007259 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1207075007260 choline dehydrogenase; Validated; Region: PRK02106 1207075007261 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1207075007262 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075007263 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075007264 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075007265 Na binding site [ion binding]; other site 1207075007266 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1207075007267 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1207075007268 active site 1207075007269 Zn binding site [ion binding]; other site 1207075007270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007271 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1207075007272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075007273 dimerization interface [polypeptide binding]; other site 1207075007274 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075007275 Transposase domain (DUF772); Region: DUF772; pfam05598 1207075007276 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075007277 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1207075007278 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1207075007279 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1207075007280 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1207075007281 putative active site [active] 1207075007282 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1207075007283 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075007284 Walker A/P-loop; other site 1207075007285 ATP binding site [chemical binding]; other site 1207075007286 Q-loop/lid; other site 1207075007287 ABC transporter signature motif; other site 1207075007288 Walker B; other site 1207075007289 D-loop; other site 1207075007290 H-loop/switch region; other site 1207075007291 Predicted deacylase [General function prediction only]; Region: COG3608 1207075007292 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1207075007293 active site 1207075007294 Zn binding site [ion binding]; other site 1207075007295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007296 dimer interface [polypeptide binding]; other site 1207075007297 conserved gate region; other site 1207075007298 putative PBP binding loops; other site 1207075007299 ABC-ATPase subunit interface; other site 1207075007300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007302 dimer interface [polypeptide binding]; other site 1207075007303 conserved gate region; other site 1207075007304 putative PBP binding loops; other site 1207075007305 ABC-ATPase subunit interface; other site 1207075007306 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075007307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075007308 substrate binding pocket [chemical binding]; other site 1207075007309 membrane-bound complex binding site; other site 1207075007310 hinge residues; other site 1207075007311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075007312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075007313 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1207075007314 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075007315 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075007316 dimer interface [polypeptide binding]; other site 1207075007317 putative CheW interface [polypeptide binding]; other site 1207075007318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075007319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075007320 active site 1207075007321 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1207075007322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075007323 substrate binding site [chemical binding]; other site 1207075007324 oxyanion hole (OAH) forming residues; other site 1207075007325 trimer interface [polypeptide binding]; other site 1207075007326 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1207075007327 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1207075007328 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1207075007329 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1207075007330 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1207075007331 tetrameric interface [polypeptide binding]; other site 1207075007332 NAD binding site [chemical binding]; other site 1207075007333 catalytic residues [active] 1207075007334 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1207075007335 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 1207075007336 active site 1207075007337 acyl-activating enzyme (AAE) consensus motif; other site 1207075007338 putative CoA binding site [chemical binding]; other site 1207075007339 AMP binding site [chemical binding]; other site 1207075007340 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075007341 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1207075007342 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1207075007343 Na binding site [ion binding]; other site 1207075007344 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1207075007345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075007346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075007348 dimerization interface [polypeptide binding]; other site 1207075007349 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1207075007350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075007351 putative NAD(P) binding site [chemical binding]; other site 1207075007352 putative active site [active] 1207075007353 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075007354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007355 dimer interface [polypeptide binding]; other site 1207075007356 conserved gate region; other site 1207075007357 putative PBP binding loops; other site 1207075007358 ABC-ATPase subunit interface; other site 1207075007359 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1207075007360 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075007361 Walker A/P-loop; other site 1207075007362 ATP binding site [chemical binding]; other site 1207075007363 Q-loop/lid; other site 1207075007364 ABC transporter signature motif; other site 1207075007365 Walker B; other site 1207075007366 D-loop; other site 1207075007367 H-loop/switch region; other site 1207075007368 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075007369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075007370 substrate binding pocket [chemical binding]; other site 1207075007371 membrane-bound complex binding site; other site 1207075007372 hinge residues; other site 1207075007373 oxidoreductase; Region: PLN02485 1207075007374 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1207075007375 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1207075007376 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1207075007377 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1207075007378 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1207075007379 potential catalytic triad [active] 1207075007380 conserved cys residue [active] 1207075007381 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1207075007382 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1207075007383 DNA binding residues [nucleotide binding] 1207075007384 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075007385 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075007386 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1207075007387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075007388 catalytic residue [active] 1207075007389 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1207075007390 active site 1207075007391 catalytic residues [active] 1207075007392 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1207075007393 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1207075007394 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075007395 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1207075007396 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1207075007397 active site 1207075007398 arsenical pump membrane protein; Provisional; Region: PRK15445 1207075007399 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1207075007400 transmembrane helices; other site 1207075007401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075007402 dimerization interface [polypeptide binding]; other site 1207075007403 putative DNA binding site [nucleotide binding]; other site 1207075007404 putative Zn2+ binding site [ion binding]; other site 1207075007405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1207075007406 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1207075007407 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1207075007408 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1207075007409 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1207075007410 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1207075007411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075007412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007413 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1207075007414 putative effector binding pocket; other site 1207075007415 putative dimerization interface [polypeptide binding]; other site 1207075007416 short chain dehydrogenase; Provisional; Region: PRK06180 1207075007417 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1207075007418 NADP binding site [chemical binding]; other site 1207075007419 active site 1207075007420 steroid binding site; other site 1207075007421 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1207075007422 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1207075007423 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075007424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075007425 DNA-binding site [nucleotide binding]; DNA binding site 1207075007426 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075007427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075007429 homodimer interface [polypeptide binding]; other site 1207075007430 catalytic residue [active] 1207075007431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075007432 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075007433 Coenzyme A binding pocket [chemical binding]; other site 1207075007434 hypothetical protein; Provisional; Region: PRK06156 1207075007435 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1207075007436 active site 1207075007437 metal binding site [ion binding]; metal-binding site 1207075007438 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1207075007439 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075007440 catalytic site [active] 1207075007441 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1207075007442 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1207075007443 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1207075007444 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1207075007445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075007446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007447 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1207075007448 putative effector binding pocket; other site 1207075007449 putative dimerization interface [polypeptide binding]; other site 1207075007450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075007451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007452 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075007453 dimerization interface [polypeptide binding]; other site 1207075007454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1207075007455 classical (c) SDRs; Region: SDR_c; cd05233 1207075007456 NAD(P) binding site [chemical binding]; other site 1207075007457 active site 1207075007458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075007459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075007460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075007461 Predicted membrane protein [Function unknown]; Region: COG2259 1207075007462 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1207075007463 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1207075007464 putative NAD(P) binding site [chemical binding]; other site 1207075007465 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1207075007466 classical (c) SDRs; Region: SDR_c; cd05233 1207075007467 NAD(P) binding site [chemical binding]; other site 1207075007468 active site 1207075007469 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1207075007470 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1207075007471 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1207075007472 tetramer interface [polypeptide binding]; other site 1207075007473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075007474 catalytic residue [active] 1207075007475 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075007476 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075007477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075007478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075007479 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1207075007480 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1207075007481 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1207075007482 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1207075007483 nucleophile elbow; other site 1207075007484 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1207075007485 Ligand Binding Site [chemical binding]; other site 1207075007486 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007487 Ligand Binding Site [chemical binding]; other site 1207075007488 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007489 Ligand Binding Site [chemical binding]; other site 1207075007490 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007491 Ligand Binding Site [chemical binding]; other site 1207075007492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075007493 Coenzyme A binding pocket [chemical binding]; other site 1207075007494 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007495 Ligand Binding Site [chemical binding]; other site 1207075007496 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007497 Ligand Binding Site [chemical binding]; other site 1207075007498 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1207075007499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075007500 ligand binding site [chemical binding]; other site 1207075007501 flexible hinge region; other site 1207075007502 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1207075007503 putative switch regulator; other site 1207075007504 non-specific DNA interactions [nucleotide binding]; other site 1207075007505 DNA binding site [nucleotide binding] 1207075007506 sequence specific DNA binding site [nucleotide binding]; other site 1207075007507 putative cAMP binding site [chemical binding]; other site 1207075007508 universal stress protein UspE; Provisional; Region: PRK11175 1207075007509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007510 Ligand Binding Site [chemical binding]; other site 1207075007511 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007512 Ligand Binding Site [chemical binding]; other site 1207075007513 Ion channel; Region: Ion_trans_2; pfam07885 1207075007514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007515 Ligand Binding Site [chemical binding]; other site 1207075007516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075007517 Ligand Binding Site [chemical binding]; other site 1207075007518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075007519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075007520 active site 1207075007521 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075007522 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075007523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075007524 lipid-transfer protein; Provisional; Region: PRK08256 1207075007525 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1207075007526 active site 1207075007527 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1207075007528 active site 1207075007529 catalytic site [active] 1207075007530 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1207075007531 active site 1207075007532 catalytic site [active] 1207075007533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075007535 NAD(P) binding site [chemical binding]; other site 1207075007536 active site 1207075007537 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075007538 Sulfatase; Region: Sulfatase; pfam00884 1207075007539 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1207075007540 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1207075007541 NAD(P) binding site [chemical binding]; other site 1207075007542 catalytic residues [active] 1207075007543 choline dehydrogenase; Validated; Region: PRK02106 1207075007544 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075007545 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1207075007546 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1207075007547 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1207075007548 TAP-like protein; Region: Abhydrolase_4; pfam08386 1207075007549 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1207075007550 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075007551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075007552 DNA binding residues [nucleotide binding] 1207075007553 dimerization interface [polypeptide binding]; other site 1207075007554 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1207075007555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075007556 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1207075007557 acyl-activating enzyme (AAE) consensus motif; other site 1207075007558 putative AMP binding site [chemical binding]; other site 1207075007559 putative active site [active] 1207075007560 putative CoA binding site [chemical binding]; other site 1207075007561 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075007562 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075007563 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1207075007564 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1207075007565 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1207075007566 YccA-like proteins; Region: YccA_like; cd10433 1207075007567 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1207075007568 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075007569 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1207075007570 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075007571 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075007572 EamA-like transporter family; Region: EamA; pfam00892 1207075007573 Predicted membrane protein [Function unknown]; Region: COG1289 1207075007574 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1207075007575 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1207075007576 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075007577 tetrameric interface [polypeptide binding]; other site 1207075007578 activator binding site; other site 1207075007579 NADP binding site [chemical binding]; other site 1207075007580 substrate binding site [chemical binding]; other site 1207075007581 catalytic residues [active] 1207075007582 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1207075007583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1207075007584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1207075007585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1207075007586 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1207075007587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075007588 DNA-binding site [nucleotide binding]; DNA binding site 1207075007589 UTRA domain; Region: UTRA; pfam07702 1207075007590 putative oxidoreductase; Provisional; Region: PRK08275 1207075007591 L-aspartate oxidase; Provisional; Region: PRK06175 1207075007592 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1207075007593 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1207075007594 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1207075007595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075007596 substrate binding pocket [chemical binding]; other site 1207075007597 membrane-bound complex binding site; other site 1207075007598 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1207075007599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007600 dimer interface [polypeptide binding]; other site 1207075007601 conserved gate region; other site 1207075007602 putative PBP binding loops; other site 1207075007603 ABC-ATPase subunit interface; other site 1207075007604 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1207075007605 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075007606 Walker A/P-loop; other site 1207075007607 ATP binding site [chemical binding]; other site 1207075007608 Q-loop/lid; other site 1207075007609 ABC transporter signature motif; other site 1207075007610 Walker B; other site 1207075007611 D-loop; other site 1207075007612 H-loop/switch region; other site 1207075007613 HEAT repeats; Region: HEAT_2; pfam13646 1207075007614 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1207075007615 HEAT repeats; Region: HEAT_2; pfam13646 1207075007616 protein binding surface [polypeptide binding]; other site 1207075007617 HEAT repeats; Region: HEAT_2; pfam13646 1207075007618 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1207075007619 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1207075007620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075007621 Walker A/P-loop; other site 1207075007622 ATP binding site [chemical binding]; other site 1207075007623 Q-loop/lid; other site 1207075007624 ABC transporter signature motif; other site 1207075007625 Walker B; other site 1207075007626 D-loop; other site 1207075007627 H-loop/switch region; other site 1207075007628 H+ Antiporter protein; Region: 2A0121; TIGR00900 1207075007629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075007630 putative substrate translocation pore; other site 1207075007631 LexA repressor; Provisional; Region: PRK12423 1207075007632 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1207075007633 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1207075007634 Catalytic site [active] 1207075007635 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1207075007636 DNA Polymerase Y-family; Region: PolY_like; cd03468 1207075007637 active site 1207075007638 DNA binding site [nucleotide binding] 1207075007639 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1207075007640 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1207075007641 putative active site [active] 1207075007642 putative PHP Thumb interface [polypeptide binding]; other site 1207075007643 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1207075007644 generic binding surface I; other site 1207075007645 generic binding surface II; other site 1207075007646 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1207075007647 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1207075007648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1207075007649 active site 1207075007650 cytosine deaminase; Provisional; Region: PRK05985 1207075007651 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1207075007652 active site 1207075007653 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075007654 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075007655 sulfate transport protein; Provisional; Region: cysT; CHL00187 1207075007656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007657 dimer interface [polypeptide binding]; other site 1207075007658 conserved gate region; other site 1207075007659 putative PBP binding loops; other site 1207075007660 ABC-ATPase subunit interface; other site 1207075007661 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1207075007662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007663 dimer interface [polypeptide binding]; other site 1207075007664 conserved gate region; other site 1207075007665 putative PBP binding loops; other site 1207075007666 ABC-ATPase subunit interface; other site 1207075007667 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075007668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075007669 Walker A/P-loop; other site 1207075007670 ATP binding site [chemical binding]; other site 1207075007671 Q-loop/lid; other site 1207075007672 ABC transporter signature motif; other site 1207075007673 Walker B; other site 1207075007674 D-loop; other site 1207075007675 H-loop/switch region; other site 1207075007676 TOBE domain; Region: TOBE_2; pfam08402 1207075007677 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075007678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075007679 DNA-binding site [nucleotide binding]; DNA binding site 1207075007680 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1207075007681 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075007682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075007683 putative active site [active] 1207075007684 heme pocket [chemical binding]; other site 1207075007685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075007686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075007687 dimer interface [polypeptide binding]; other site 1207075007688 phosphorylation site [posttranslational modification] 1207075007689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075007690 ATP binding site [chemical binding]; other site 1207075007691 Mg2+ binding site [ion binding]; other site 1207075007692 G-X-G motif; other site 1207075007693 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075007694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007695 active site 1207075007696 phosphorylation site [posttranslational modification] 1207075007697 intermolecular recognition site; other site 1207075007698 dimerization interface [polypeptide binding]; other site 1207075007699 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1207075007700 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1207075007701 Strictosidine synthase; Region: Str_synth; pfam03088 1207075007702 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1207075007703 hydrophobic ligand binding site; other site 1207075007704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075007705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075007706 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075007707 dimerization interface [polypeptide binding]; other site 1207075007708 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1207075007709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1207075007710 catalytic core [active] 1207075007711 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1207075007712 putative inner membrane peptidase; Provisional; Region: PRK11778 1207075007713 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1207075007714 tandem repeat interface [polypeptide binding]; other site 1207075007715 oligomer interface [polypeptide binding]; other site 1207075007716 active site residues [active] 1207075007717 Leucine rich repeat; Region: LRR_8; pfam13855 1207075007718 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1207075007719 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1207075007720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1207075007721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1207075007722 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1207075007723 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 1207075007724 putative ligand binding site [chemical binding]; other site 1207075007725 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1207075007726 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1207075007727 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1207075007728 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1207075007729 substrate binding pocket [chemical binding]; other site 1207075007730 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1207075007731 B12 binding site [chemical binding]; other site 1207075007732 cobalt ligand [ion binding]; other site 1207075007733 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1207075007734 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1207075007735 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1207075007736 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1207075007737 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1207075007738 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1207075007739 active site 1207075007740 SAM binding site [chemical binding]; other site 1207075007741 homodimer interface [polypeptide binding]; other site 1207075007742 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1207075007743 Predicted integral membrane protein [Function unknown]; Region: COG5446 1207075007744 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 1207075007745 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1207075007746 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1207075007747 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1207075007748 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1207075007749 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1207075007750 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1207075007751 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1207075007752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075007753 Walker A motif; other site 1207075007754 ATP binding site [chemical binding]; other site 1207075007755 Walker B motif; other site 1207075007756 arginine finger; other site 1207075007757 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1207075007758 metal ion-dependent adhesion site (MIDAS); other site 1207075007759 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075007760 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1207075007761 putative active site [active] 1207075007762 putative FMN binding site [chemical binding]; other site 1207075007763 putative substrate binding site [chemical binding]; other site 1207075007764 putative catalytic residue [active] 1207075007765 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1207075007766 homotrimer interaction site [polypeptide binding]; other site 1207075007767 putative active site [active] 1207075007768 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1207075007769 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1207075007770 dimer interface [polypeptide binding]; other site 1207075007771 active site 1207075007772 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1207075007773 substrate binding site [chemical binding]; other site 1207075007774 catalytic residue [active] 1207075007775 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1207075007776 PAS fold; Region: PAS_4; pfam08448 1207075007777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075007778 putative active site [active] 1207075007779 PAS fold; Region: PAS_3; pfam08447 1207075007780 heme pocket [chemical binding]; other site 1207075007781 PAS fold; Region: PAS_4; pfam08448 1207075007782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075007783 putative active site [active] 1207075007784 heme pocket [chemical binding]; other site 1207075007785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075007786 dimer interface [polypeptide binding]; other site 1207075007787 phosphorylation site [posttranslational modification] 1207075007788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075007789 ATP binding site [chemical binding]; other site 1207075007790 Mg2+ binding site [ion binding]; other site 1207075007791 G-X-G motif; other site 1207075007792 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075007793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007794 active site 1207075007795 phosphorylation site [posttranslational modification] 1207075007796 intermolecular recognition site; other site 1207075007797 dimerization interface [polypeptide binding]; other site 1207075007798 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1207075007799 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1207075007800 acyl-activating enzyme (AAE) consensus motif; other site 1207075007801 putative AMP binding site [chemical binding]; other site 1207075007802 putative active site [active] 1207075007803 putative CoA binding site [chemical binding]; other site 1207075007804 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1207075007805 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1207075007806 NAD binding site [chemical binding]; other site 1207075007807 homotetramer interface [polypeptide binding]; other site 1207075007808 homodimer interface [polypeptide binding]; other site 1207075007809 substrate binding site [chemical binding]; other site 1207075007810 active site 1207075007811 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1207075007812 PAS domain; Region: PAS; smart00091 1207075007813 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1207075007814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075007815 Walker B motif; other site 1207075007816 arginine finger; other site 1207075007817 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075007818 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1207075007819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1207075007820 Walker A/P-loop; other site 1207075007821 ATP binding site [chemical binding]; other site 1207075007822 Q-loop/lid; other site 1207075007823 ABC transporter signature motif; other site 1207075007824 Walker B; other site 1207075007825 D-loop; other site 1207075007826 H-loop/switch region; other site 1207075007827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1207075007828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1207075007829 Walker A/P-loop; other site 1207075007830 ATP binding site [chemical binding]; other site 1207075007831 Q-loop/lid; other site 1207075007832 ABC transporter signature motif; other site 1207075007833 Walker B; other site 1207075007834 D-loop; other site 1207075007835 H-loop/switch region; other site 1207075007836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1207075007837 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1207075007838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007839 dimer interface [polypeptide binding]; other site 1207075007840 conserved gate region; other site 1207075007841 putative PBP binding loops; other site 1207075007842 ABC-ATPase subunit interface; other site 1207075007843 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1207075007844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007845 dimer interface [polypeptide binding]; other site 1207075007846 conserved gate region; other site 1207075007847 putative PBP binding loops; other site 1207075007848 ABC-ATPase subunit interface; other site 1207075007849 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1207075007850 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1207075007851 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1207075007852 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1207075007853 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1207075007854 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1207075007855 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075007856 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1207075007857 active site 1207075007858 catalytic triad [active] 1207075007859 dimer interface [polypeptide binding]; other site 1207075007860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075007861 Coenzyme A binding pocket [chemical binding]; other site 1207075007862 response regulator; Provisional; Region: PRK09483 1207075007863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075007864 active site 1207075007865 phosphorylation site [posttranslational modification] 1207075007866 intermolecular recognition site; other site 1207075007867 dimerization interface [polypeptide binding]; other site 1207075007868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075007869 DNA binding residues [nucleotide binding] 1207075007870 dimerization interface [polypeptide binding]; other site 1207075007871 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1207075007872 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1207075007873 GIY-YIG motif/motif A; other site 1207075007874 active site 1207075007875 catalytic site [active] 1207075007876 putative DNA binding site [nucleotide binding]; other site 1207075007877 metal binding site [ion binding]; metal-binding site 1207075007878 UvrB/uvrC motif; Region: UVR; pfam02151 1207075007879 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1207075007880 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1207075007881 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1207075007882 PLD-like domain; Region: PLDc_2; pfam13091 1207075007883 putative active site [active] 1207075007884 catalytic site [active] 1207075007885 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1207075007886 PLD-like domain; Region: PLDc_2; pfam13091 1207075007887 putative active site [active] 1207075007888 catalytic site [active] 1207075007889 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075007890 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075007891 catalytic residue [active] 1207075007892 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1207075007893 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1207075007894 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1207075007895 active site 1207075007896 DNA binding site [nucleotide binding] 1207075007897 Int/Topo IB signature motif; other site 1207075007898 catalytic residues [active] 1207075007899 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1207075007900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075007901 Walker A/P-loop; other site 1207075007902 ATP binding site [chemical binding]; other site 1207075007903 Q-loop/lid; other site 1207075007904 ABC transporter signature motif; other site 1207075007905 Walker B; other site 1207075007906 D-loop; other site 1207075007907 H-loop/switch region; other site 1207075007908 TOBE domain; Region: TOBE; cl01440 1207075007909 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1207075007910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075007911 dimer interface [polypeptide binding]; other site 1207075007912 conserved gate region; other site 1207075007913 putative PBP binding loops; other site 1207075007914 ABC-ATPase subunit interface; other site 1207075007915 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1207075007916 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 1207075007917 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1207075007918 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1207075007919 FMN binding site [chemical binding]; other site 1207075007920 substrate binding site [chemical binding]; other site 1207075007921 putative catalytic residue [active] 1207075007922 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1207075007923 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1207075007924 NADP binding site [chemical binding]; other site 1207075007925 dimer interface [polypeptide binding]; other site 1207075007926 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1207075007927 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1207075007928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075007929 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1207075007930 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1207075007931 DNA binding site [nucleotide binding] 1207075007932 active site 1207075007933 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1207075007934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1207075007935 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1207075007936 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1207075007937 active site 1207075007938 tetramer interface; other site 1207075007939 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1207075007940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075007941 putative substrate translocation pore; other site 1207075007942 glutathione reductase; Validated; Region: PRK06116 1207075007943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075007944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075007945 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1207075007946 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1207075007947 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1207075007948 DNA binding site [nucleotide binding] 1207075007949 dimer interface [polypeptide binding]; other site 1207075007950 active site 1207075007951 Int/Topo IB signature motif; other site 1207075007952 peroxiredoxin; Region: AhpC; TIGR03137 1207075007953 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1207075007954 dimer interface [polypeptide binding]; other site 1207075007955 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1207075007956 catalytic triad [active] 1207075007957 peroxidatic and resolving cysteines [active] 1207075007958 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1207075007959 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1207075007960 catalytic residue [active] 1207075007961 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1207075007962 catalytic residues [active] 1207075007963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075007964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075007965 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1207075007966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075007967 dimer interface [polypeptide binding]; other site 1207075007968 active site 1207075007969 metal binding site [ion binding]; metal-binding site 1207075007970 glutathione binding site [chemical binding]; other site 1207075007971 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1207075007972 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1207075007973 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075007974 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1207075007975 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1207075007976 dimer interface [polypeptide binding]; other site 1207075007977 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1207075007978 active site 1207075007979 Fe binding site [ion binding]; other site 1207075007980 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1207075007981 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075007982 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075007983 active site 1207075007984 catalytic tetrad [active] 1207075007985 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1207075007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075007987 putative substrate translocation pore; other site 1207075007988 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1207075007989 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1207075007990 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1207075007991 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1207075007992 aspartate aminotransferase; Provisional; Region: PRK05764 1207075007993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075007994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075007995 homodimer interface [polypeptide binding]; other site 1207075007996 catalytic residue [active] 1207075007997 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1207075007998 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1207075007999 dimerization interface [polypeptide binding]; other site 1207075008000 ligand binding site [chemical binding]; other site 1207075008001 NADP binding site [chemical binding]; other site 1207075008002 catalytic site [active] 1207075008003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008004 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075008005 putative substrate translocation pore; other site 1207075008006 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1207075008007 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1207075008008 substrate binding site [chemical binding]; other site 1207075008009 ATP binding site [chemical binding]; other site 1207075008010 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1207075008011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1207075008012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1207075008013 DNA binding site [nucleotide binding] 1207075008014 domain linker motif; other site 1207075008015 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1207075008016 putative dimerization interface [polypeptide binding]; other site 1207075008017 putative ligand binding site [chemical binding]; other site 1207075008018 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075008019 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075008020 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075008021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008022 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1207075008023 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1207075008024 Protein export membrane protein; Region: SecD_SecF; cl14618 1207075008025 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1207075008026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075008027 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075008028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075008029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008030 active site 1207075008031 phosphorylation site [posttranslational modification] 1207075008032 intermolecular recognition site; other site 1207075008033 dimerization interface [polypeptide binding]; other site 1207075008034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075008035 DNA binding site [nucleotide binding] 1207075008036 sensor protein RstB; Provisional; Region: PRK10604 1207075008037 HAMP domain; Region: HAMP; pfam00672 1207075008038 dimerization interface [polypeptide binding]; other site 1207075008039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075008040 dimer interface [polypeptide binding]; other site 1207075008041 phosphorylation site [posttranslational modification] 1207075008042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008043 ATP binding site [chemical binding]; other site 1207075008044 Mg2+ binding site [ion binding]; other site 1207075008045 G-X-G motif; other site 1207075008046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075008047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075008048 DNA binding residues [nucleotide binding] 1207075008049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075008050 binding surface 1207075008051 TPR motif; other site 1207075008052 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1207075008053 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1207075008054 dimerization interface [polypeptide binding]; other site 1207075008055 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1207075008056 NAD binding site [chemical binding]; other site 1207075008057 ligand binding site [chemical binding]; other site 1207075008058 catalytic site [active] 1207075008059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075008060 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1207075008061 Predicted membrane protein [Function unknown]; Region: COG1238 1207075008062 Protein of unknown function, DUF; Region: DUF411; cl01142 1207075008063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075008064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075008065 active site 1207075008066 catalytic tetrad [active] 1207075008067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008069 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1207075008070 putative effector binding pocket; other site 1207075008071 putative dimerization interface [polypeptide binding]; other site 1207075008072 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1207075008073 Penicillin amidase; Region: Penicil_amidase; pfam01804 1207075008074 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1207075008075 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1207075008076 active site 1207075008077 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1207075008078 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1207075008079 FecR protein; Region: FecR; pfam04773 1207075008080 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1207075008081 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1207075008082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008084 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1207075008085 putative substrate binding pocket [chemical binding]; other site 1207075008086 putative dimerization interface [polypeptide binding]; other site 1207075008087 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1207075008088 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075008089 putative active site [active] 1207075008090 catalytic triad [active] 1207075008091 putative dimer interface [polypeptide binding]; other site 1207075008092 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1207075008093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075008094 acyl-activating enzyme (AAE) consensus motif; other site 1207075008095 AMP binding site [chemical binding]; other site 1207075008096 active site 1207075008097 CoA binding site [chemical binding]; other site 1207075008098 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1207075008099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075008100 NAD(P) binding site [chemical binding]; other site 1207075008101 active site 1207075008102 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1207075008103 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075008104 dimer interface [polypeptide binding]; other site 1207075008105 active site 1207075008106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075008107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075008108 active site 1207075008109 enoyl-CoA hydratase; Provisional; Region: PRK05862 1207075008110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075008111 substrate binding site [chemical binding]; other site 1207075008112 oxyanion hole (OAH) forming residues; other site 1207075008113 trimer interface [polypeptide binding]; other site 1207075008114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075008115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075008116 active site 1207075008117 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1207075008118 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075008119 substrate binding site [chemical binding]; other site 1207075008120 oxyanion hole (OAH) forming residues; other site 1207075008121 trimer interface [polypeptide binding]; other site 1207075008122 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1207075008123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075008126 dimerization interface [polypeptide binding]; other site 1207075008127 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075008128 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075008129 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1207075008130 agmatinase; Region: agmatinase; TIGR01230 1207075008131 oligomer interface [polypeptide binding]; other site 1207075008132 putative active site [active] 1207075008133 Mn binding site [ion binding]; other site 1207075008134 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075008135 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075008136 active site 1207075008137 catalytic tetrad [active] 1207075008138 Predicted ATPase [General function prediction only]; Region: COG1485 1207075008139 DinB family; Region: DinB; cl17821 1207075008140 DinB superfamily; Region: DinB_2; pfam12867 1207075008141 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075008142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075008143 Coenzyme A binding pocket [chemical binding]; other site 1207075008144 hypothetical protein; Provisional; Region: PRK10649 1207075008145 Sulfatase; Region: Sulfatase; pfam00884 1207075008146 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1207075008147 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1207075008148 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1207075008149 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1207075008150 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1207075008151 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1207075008152 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075008153 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075008154 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075008155 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075008156 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075008157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075008158 Walker A motif; other site 1207075008159 ATP binding site [chemical binding]; other site 1207075008160 Walker B motif; other site 1207075008161 arginine finger; other site 1207075008162 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075008163 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1207075008164 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1207075008165 putative active site [active] 1207075008166 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1207075008167 AAA domain; Region: AAA_28; pfam13521 1207075008168 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1207075008169 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1207075008170 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1207075008171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1207075008172 LysR family transcriptional regulator; Provisional; Region: PRK14997 1207075008173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075008174 dimerization interface [polypeptide binding]; other site 1207075008175 azoreductase; Reviewed; Region: PRK00170 1207075008176 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075008177 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1207075008178 major facilitator superfamily transporter; Provisional; Region: PRK05122 1207075008179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008180 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1207075008181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075008182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075008183 Walker A/P-loop; other site 1207075008184 ATP binding site [chemical binding]; other site 1207075008185 ABC transporter signature motif; other site 1207075008186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075008187 Walker B; other site 1207075008188 ABC transporter; Region: ABC_tran_2; pfam12848 1207075008189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075008190 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1207075008191 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1207075008192 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1207075008193 putative DNA binding site [nucleotide binding]; other site 1207075008194 putative homodimer interface [polypeptide binding]; other site 1207075008195 RAM signalling pathway protein; Region: SOG2; pfam10428 1207075008196 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1207075008197 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1207075008198 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075008199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075008200 Coenzyme A binding pocket [chemical binding]; other site 1207075008201 Peptidase_C39 like family; Region: DUF3335; pfam11814 1207075008202 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1207075008203 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1207075008204 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1207075008205 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1207075008206 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1207075008207 oligomer interface [polypeptide binding]; other site 1207075008208 Cl binding site [ion binding]; other site 1207075008209 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1207075008210 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1207075008211 tetramer interface [polypeptide binding]; other site 1207075008212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008213 catalytic residue [active] 1207075008214 ecotin; Provisional; Region: PRK03719 1207075008215 secondary substrate binding site; other site 1207075008216 primary substrate binding site; other site 1207075008217 inhibition loop; other site 1207075008218 dimerization interface [polypeptide binding]; other site 1207075008219 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1207075008220 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1207075008221 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1207075008222 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1207075008223 putative substrate binding site [chemical binding]; other site 1207075008224 putative ATP binding site [chemical binding]; other site 1207075008225 Catalytic domain of bacterial phosphatidylinositol-specific phospholipase C and similar proteins; Region: PI-PLCc_bacteria_like; cd08557 1207075008226 active site 1207075008227 catalytic site [active] 1207075008228 Catalytic domain of bacterial phosphatidylinositol-specific phospholipase C and similar proteins; Region: PI-PLCc_bacteria_like; cd08557 1207075008229 active site 1207075008230 catalytic site [active] 1207075008231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075008232 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1207075008233 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075008234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008235 active site 1207075008236 phosphorylation site [posttranslational modification] 1207075008237 intermolecular recognition site; other site 1207075008238 dimerization interface [polypeptide binding]; other site 1207075008239 CHASE3 domain; Region: CHASE3; pfam05227 1207075008240 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1207075008241 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1207075008242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075008243 dimer interface [polypeptide binding]; other site 1207075008244 phosphorylation site [posttranslational modification] 1207075008245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008246 ATP binding site [chemical binding]; other site 1207075008247 Mg2+ binding site [ion binding]; other site 1207075008248 G-X-G motif; other site 1207075008249 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075008250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008251 active site 1207075008252 phosphorylation site [posttranslational modification] 1207075008253 intermolecular recognition site; other site 1207075008254 dimerization interface [polypeptide binding]; other site 1207075008255 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075008256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008257 active site 1207075008258 phosphorylation site [posttranslational modification] 1207075008259 intermolecular recognition site; other site 1207075008260 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075008261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008262 active site 1207075008263 phosphorylation site [posttranslational modification] 1207075008264 intermolecular recognition site; other site 1207075008265 dimerization interface [polypeptide binding]; other site 1207075008266 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1207075008267 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1207075008268 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1207075008269 CheB methylesterase; Region: CheB_methylest; pfam01339 1207075008270 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075008271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008272 active site 1207075008273 phosphorylation site [posttranslational modification] 1207075008274 intermolecular recognition site; other site 1207075008275 dimerization interface [polypeptide binding]; other site 1207075008276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075008277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075008278 dimer interface [polypeptide binding]; other site 1207075008279 phosphorylation site [posttranslational modification] 1207075008280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008281 ATP binding site [chemical binding]; other site 1207075008282 Mg2+ binding site [ion binding]; other site 1207075008283 G-X-G motif; other site 1207075008284 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075008285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008286 active site 1207075008287 phosphorylation site [posttranslational modification] 1207075008288 intermolecular recognition site; other site 1207075008289 dimerization interface [polypeptide binding]; other site 1207075008290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1207075008291 dimer interface [polypeptide binding]; other site 1207075008292 phosphorylation site [posttranslational modification] 1207075008293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008294 ATP binding site [chemical binding]; other site 1207075008295 Mg2+ binding site [ion binding]; other site 1207075008296 G-X-G motif; other site 1207075008297 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075008298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008299 active site 1207075008300 phosphorylation site [posttranslational modification] 1207075008301 intermolecular recognition site; other site 1207075008302 dimerization interface [polypeptide binding]; other site 1207075008303 circadian clock protein KaiC; Reviewed; Region: PRK09302 1207075008304 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1207075008305 Walker A motif; other site 1207075008306 ATP binding site [chemical binding]; other site 1207075008307 Walker B motif; other site 1207075008308 recA bacterial DNA recombination protein; Region: RecA; cl17211 1207075008309 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1207075008310 Walker A motif; other site 1207075008311 ATP binding site [chemical binding]; other site 1207075008312 Walker B motif; other site 1207075008313 Fungal symportin 1 (syo1) and similar proteins; Region: Syo1_like; cd13394 1207075008314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075008315 TPR motif; other site 1207075008316 binding surface 1207075008317 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1207075008318 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1207075008319 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1207075008320 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1207075008321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075008322 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075008323 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1207075008324 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1207075008325 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075008326 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075008327 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075008328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008330 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1207075008331 putative substrate binding pocket [chemical binding]; other site 1207075008332 putative dimerization interface [polypeptide binding]; other site 1207075008333 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1207075008334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1207075008335 putative NAD(P) binding site [chemical binding]; other site 1207075008336 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075008337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075008338 DNA-binding site [nucleotide binding]; DNA binding site 1207075008339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075008340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008341 homodimer interface [polypeptide binding]; other site 1207075008342 catalytic residue [active] 1207075008343 phosphoglucomutase; Validated; Region: PRK07564 1207075008344 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1207075008345 active site 1207075008346 substrate binding site [chemical binding]; other site 1207075008347 metal binding site [ion binding]; metal-binding site 1207075008348 Pirin-related protein [General function prediction only]; Region: COG1741 1207075008349 Pirin; Region: Pirin; pfam02678 1207075008350 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1207075008351 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1207075008352 Family description; Region: UvrD_C_2; pfam13538 1207075008353 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1207075008354 SnoaL-like domain; Region: SnoaL_2; pfam12680 1207075008355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075008356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008357 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075008358 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075008359 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1207075008360 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075008361 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075008362 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1207075008363 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1207075008364 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1207075008365 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1207075008366 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1207075008367 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1207075008368 ATP binding site [chemical binding]; other site 1207075008369 DEAD_2; Region: DEAD_2; pfam06733 1207075008370 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1207075008371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075008372 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075008373 putative active site [active] 1207075008374 heme pocket [chemical binding]; other site 1207075008375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075008376 putative active site [active] 1207075008377 heme pocket [chemical binding]; other site 1207075008378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075008379 dimer interface [polypeptide binding]; other site 1207075008380 phosphorylation site [posttranslational modification] 1207075008381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008382 ATP binding site [chemical binding]; other site 1207075008383 Mg2+ binding site [ion binding]; other site 1207075008384 G-X-G motif; other site 1207075008385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008386 active site 1207075008387 phosphorylation site [posttranslational modification] 1207075008388 intermolecular recognition site; other site 1207075008389 dimerization interface [polypeptide binding]; other site 1207075008390 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1207075008391 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1207075008392 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1207075008393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075008394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008395 homodimer interface [polypeptide binding]; other site 1207075008396 catalytic residue [active] 1207075008397 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1207075008398 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1207075008399 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1207075008400 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1207075008401 molybdopterin cofactor binding site; other site 1207075008402 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1207075008403 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1207075008404 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1207075008405 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1207075008406 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1207075008407 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1207075008408 selenocysteine synthase; Provisional; Region: PRK04311 1207075008409 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1207075008410 catalytic residue [active] 1207075008411 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1207075008412 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1207075008413 G1 box; other site 1207075008414 putative GEF interaction site [polypeptide binding]; other site 1207075008415 GTP/Mg2+ binding site [chemical binding]; other site 1207075008416 Switch I region; other site 1207075008417 G2 box; other site 1207075008418 G3 box; other site 1207075008419 Switch II region; other site 1207075008420 G4 box; other site 1207075008421 G5 box; other site 1207075008422 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1207075008423 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1207075008424 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1207075008425 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1207075008426 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1207075008427 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1207075008428 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075008429 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 1207075008430 acetyl-CoA synthetase; Provisional; Region: PRK00174 1207075008431 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1207075008432 active site 1207075008433 CoA binding site [chemical binding]; other site 1207075008434 acyl-activating enzyme (AAE) consensus motif; other site 1207075008435 AMP binding site [chemical binding]; other site 1207075008436 acetate binding site [chemical binding]; other site 1207075008437 Cache domain; Region: Cache_1; pfam02743 1207075008438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1207075008439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075008440 dimerization interface [polypeptide binding]; other site 1207075008441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075008442 dimer interface [polypeptide binding]; other site 1207075008443 putative CheW interface [polypeptide binding]; other site 1207075008444 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075008445 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075008446 NAD(P) binding site [chemical binding]; other site 1207075008447 catalytic residues [active] 1207075008448 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1207075008449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075008450 motif II; other site 1207075008451 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1207075008452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008453 putative substrate translocation pore; other site 1207075008454 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1207075008455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075008456 catalytic residue [active] 1207075008457 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075008458 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075008459 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1207075008460 homotrimer interaction site [polypeptide binding]; other site 1207075008461 putative active site [active] 1207075008462 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1207075008463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075008465 dimerization interface [polypeptide binding]; other site 1207075008466 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1207075008467 potassium uptake protein; Region: kup; TIGR00794 1207075008468 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 1207075008469 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1207075008470 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1207075008471 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075008472 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075008473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008474 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1207075008475 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1207075008476 dimer interface [polypeptide binding]; other site 1207075008477 acyl-activating enzyme (AAE) consensus motif; other site 1207075008478 putative active site [active] 1207075008479 AMP binding site [chemical binding]; other site 1207075008480 putative CoA binding site [chemical binding]; other site 1207075008481 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1207075008482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075008483 DNA binding residues [nucleotide binding] 1207075008484 dimerization interface [polypeptide binding]; other site 1207075008485 lipid-transfer protein; Provisional; Region: PRK08256 1207075008486 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1207075008487 active site 1207075008488 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075008489 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075008490 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1207075008491 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1207075008492 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1207075008493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075008494 FeS/SAM binding site; other site 1207075008495 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1207075008496 classical (c) SDRs; Region: SDR_c; cd05233 1207075008497 NAD(P) binding site [chemical binding]; other site 1207075008498 active site 1207075008499 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075008500 Sulfatase; Region: Sulfatase; pfam00884 1207075008501 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1207075008502 classical (c) SDRs; Region: SDR_c; cd05233 1207075008503 NAD(P) binding site [chemical binding]; other site 1207075008504 active site 1207075008505 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1207075008506 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1207075008507 active site 1207075008508 acyl-CoA synthetase; Validated; Region: PRK06188 1207075008509 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075008510 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1207075008511 acyl-activating enzyme (AAE) consensus motif; other site 1207075008512 putative AMP binding site [chemical binding]; other site 1207075008513 putative active site [active] 1207075008514 putative CoA binding site [chemical binding]; other site 1207075008515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075008516 NAD(P) binding site [chemical binding]; other site 1207075008517 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075008518 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1207075008519 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1207075008520 active site 1207075008521 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075008522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008524 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1207075008525 active site 1207075008526 catalytic residues [active] 1207075008527 DNA binding site [nucleotide binding] 1207075008528 Int/Topo IB signature motif; other site 1207075008529 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1207075008530 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075008531 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1207075008532 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1207075008533 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1207075008534 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1207075008535 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1207075008536 putative NAD(P) binding site [chemical binding]; other site 1207075008537 dimer interface [polypeptide binding]; other site 1207075008538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008540 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075008541 putative effector binding pocket; other site 1207075008542 dimerization interface [polypeptide binding]; other site 1207075008543 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075008544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075008546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008547 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1207075008548 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1207075008549 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1207075008550 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075008551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008552 metabolite-proton symporter; Region: 2A0106; TIGR00883 1207075008553 putative substrate translocation pore; other site 1207075008554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075008555 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1207075008556 substrate binding site [chemical binding]; other site 1207075008557 oxyanion hole (OAH) forming residues; other site 1207075008558 trimer interface [polypeptide binding]; other site 1207075008559 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1207075008560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075008561 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1207075008562 acyl-activating enzyme (AAE) consensus motif; other site 1207075008563 acyl-activating enzyme (AAE) consensus motif; other site 1207075008564 putative AMP binding site [chemical binding]; other site 1207075008565 putative active site [active] 1207075008566 putative CoA binding site [chemical binding]; other site 1207075008567 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1207075008568 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1207075008569 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1207075008570 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1207075008571 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1207075008572 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1207075008573 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075008574 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1207075008575 putative hydrophobic ligand binding site [chemical binding]; other site 1207075008576 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1207075008577 GAF domain; Region: GAF; pfam01590 1207075008578 PAS domain S-box; Region: sensory_box; TIGR00229 1207075008579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075008580 putative active site [active] 1207075008581 heme pocket [chemical binding]; other site 1207075008582 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075008583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075008584 metal binding site [ion binding]; metal-binding site 1207075008585 active site 1207075008586 I-site; other site 1207075008587 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075008588 Predicted transporter component [General function prediction only]; Region: COG2391 1207075008589 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1207075008590 Predicted transporter component [General function prediction only]; Region: COG2391 1207075008591 Sulphur transport; Region: Sulf_transp; pfam04143 1207075008592 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1207075008593 Right handed beta helix region; Region: Beta_helix; pfam13229 1207075008594 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1207075008595 Cadherin repeat-like domain; Region: CA_like; cl15786 1207075008596 Ca2+ binding site [ion binding]; other site 1207075008597 Cadherin repeat-like domain; Region: CA_like; cl15786 1207075008598 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1207075008599 Ca2+ binding site [ion binding]; other site 1207075008600 Protein of unknown function (DUF2717); Region: DUF2717; cl17568 1207075008601 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1207075008602 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1207075008603 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075008604 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075008605 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1207075008606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075008607 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1207075008608 Walker A/P-loop; other site 1207075008609 ATP binding site [chemical binding]; other site 1207075008610 Q-loop/lid; other site 1207075008611 ABC transporter signature motif; other site 1207075008612 Walker B; other site 1207075008613 D-loop; other site 1207075008614 H-loop/switch region; other site 1207075008615 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1207075008616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075008617 dimer interface [polypeptide binding]; other site 1207075008618 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1207075008619 putative CheW interface [polypeptide binding]; other site 1207075008620 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1207075008621 FOG: CBS domain [General function prediction only]; Region: COG0517 1207075008622 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1207075008623 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075008624 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1207075008625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1207075008626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075008627 putative metal binding site [ion binding]; other site 1207075008628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008630 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1207075008631 putative dimerization interface [polypeptide binding]; other site 1207075008632 Endonuclease I; Region: Endonuclease_1; pfam04231 1207075008633 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1207075008634 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075008635 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1207075008636 NAD(P) binding site [chemical binding]; other site 1207075008637 catalytic residues [active] 1207075008638 homoserine dehydrogenase; Provisional; Region: PRK06270 1207075008639 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1207075008640 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1207075008641 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075008642 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1207075008643 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075008644 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1207075008645 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1207075008646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008647 catalytic residue [active] 1207075008648 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075008649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008650 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075008651 dimerization interface [polypeptide binding]; other site 1207075008652 substrate binding pocket [chemical binding]; other site 1207075008653 S-methylmethionine transporter; Provisional; Region: PRK11387 1207075008654 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1207075008655 cystathionine gamma-synthase; Provisional; Region: PRK08249 1207075008656 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1207075008657 homodimer interface [polypeptide binding]; other site 1207075008658 substrate-cofactor binding pocket; other site 1207075008659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008660 catalytic residue [active] 1207075008661 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1207075008662 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075008663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008667 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075008668 putative effector binding pocket; other site 1207075008669 dimerization interface [polypeptide binding]; other site 1207075008670 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1207075008671 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075008672 benzoate transporter; Region: benE; TIGR00843 1207075008673 Benzoate membrane transport protein; Region: BenE; pfam03594 1207075008674 benzoate transport; Region: 2A0115; TIGR00895 1207075008675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008676 putative substrate translocation pore; other site 1207075008677 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1207075008678 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1207075008679 putative metal binding site [ion binding]; other site 1207075008680 putative homodimer interface [polypeptide binding]; other site 1207075008681 putative homotetramer interface [polypeptide binding]; other site 1207075008682 putative homodimer-homodimer interface [polypeptide binding]; other site 1207075008683 putative allosteric switch controlling residues; other site 1207075008684 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1207075008685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1207075008686 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1207075008687 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1207075008688 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1207075008689 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1207075008690 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1207075008691 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1207075008692 active site 1207075008693 non-prolyl cis peptide bond; other site 1207075008694 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075008695 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1207075008696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075008697 putative PBP binding loops; other site 1207075008698 dimer interface [polypeptide binding]; other site 1207075008699 ABC-ATPase subunit interface; other site 1207075008700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075008701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075008702 substrate binding pocket [chemical binding]; other site 1207075008703 membrane-bound complex binding site; other site 1207075008704 hinge residues; other site 1207075008705 Predicted membrane protein [Function unknown]; Region: COG3503 1207075008706 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1207075008707 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075008708 P-loop; other site 1207075008709 Magnesium ion binding site [ion binding]; other site 1207075008710 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075008711 Magnesium ion binding site [ion binding]; other site 1207075008712 Ion channel; Region: Ion_trans_2; pfam07885 1207075008713 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1207075008714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1207075008715 active site 1207075008716 metal binding site [ion binding]; metal-binding site 1207075008717 homotetramer interface [polypeptide binding]; other site 1207075008718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075008719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075008720 Predicted transcriptional regulators [Transcription]; Region: COG1733 1207075008721 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1207075008722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075008723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008724 putative substrate translocation pore; other site 1207075008725 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1207075008726 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1207075008727 GAF domain; Region: GAF; cl17456 1207075008728 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1207075008729 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1207075008730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075008731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075008732 metal binding site [ion binding]; metal-binding site 1207075008733 active site 1207075008734 I-site; other site 1207075008735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075008736 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075008737 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1207075008738 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1207075008739 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1207075008740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008741 metabolite-proton symporter; Region: 2A0106; TIGR00883 1207075008742 putative substrate translocation pore; other site 1207075008743 topology modulation protein; Reviewed; Region: PRK08118 1207075008744 AAA domain; Region: AAA_17; pfam13207 1207075008745 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075008746 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075008747 substrate binding pocket [chemical binding]; other site 1207075008748 membrane-bound complex binding site; other site 1207075008749 hinge residues; other site 1207075008750 putrescine transporter; Provisional; Region: potE; PRK10655 1207075008751 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075008752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075008753 DNA-binding site [nucleotide binding]; DNA binding site 1207075008754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075008755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008756 homodimer interface [polypeptide binding]; other site 1207075008757 catalytic residue [active] 1207075008758 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1207075008759 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075008760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075008761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075008762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075008763 dimer interface [polypeptide binding]; other site 1207075008764 phosphorylation site [posttranslational modification] 1207075008765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008766 ATP binding site [chemical binding]; other site 1207075008767 Mg2+ binding site [ion binding]; other site 1207075008768 G-X-G motif; other site 1207075008769 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1207075008770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008771 active site 1207075008772 phosphorylation site [posttranslational modification] 1207075008773 intermolecular recognition site; other site 1207075008774 dimerization interface [polypeptide binding]; other site 1207075008775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075008776 DNA binding site [nucleotide binding] 1207075008777 short chain dehydrogenase; Provisional; Region: PRK09072 1207075008778 classical (c) SDRs; Region: SDR_c; cd05233 1207075008779 NAD(P) binding site [chemical binding]; other site 1207075008780 active site 1207075008781 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1207075008782 heme binding pocket [chemical binding]; other site 1207075008783 heme ligand [chemical binding]; other site 1207075008784 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1207075008785 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 1207075008786 acyl-activating enzyme (AAE) consensus motif; other site 1207075008787 putative AMP binding site [chemical binding]; other site 1207075008788 putative active site [active] 1207075008789 putative CoA binding site [chemical binding]; other site 1207075008790 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1207075008791 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1207075008792 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1207075008793 MarR family; Region: MarR; pfam01047 1207075008794 OsmC-like protein; Region: OsmC; cl00767 1207075008795 OsmC-like protein; Region: OsmC; cl00767 1207075008796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1207075008797 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1207075008798 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075008799 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1207075008800 catalytic triad [active] 1207075008801 conserved cis-peptide bond; other site 1207075008802 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075008803 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075008804 conserved cys residue [active] 1207075008805 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1207075008806 Family of unknown function (DUF633); Region: DUF633; pfam04816 1207075008807 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1207075008808 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1207075008809 tetramer interface [polypeptide binding]; other site 1207075008810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008811 catalytic residue [active] 1207075008812 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075008813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008815 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1207075008816 Predicted small integral membrane protein [Function unknown]; Region: COG5605 1207075008817 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 1207075008818 Subunit I/III interface [polypeptide binding]; other site 1207075008819 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1207075008820 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1207075008821 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1207075008822 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1207075008823 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1207075008824 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075008825 Cytochrome c; Region: Cytochrom_C; cl11414 1207075008826 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1207075008827 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1207075008828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1207075008829 DNA binding site [nucleotide binding] 1207075008830 Helix-turn-helix domain; Region: HTH_18; pfam12833 1207075008831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075008832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075008833 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1207075008834 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1207075008835 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1207075008836 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075008837 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1207075008838 iron-sulfur cluster [ion binding]; other site 1207075008839 [2Fe-2S] cluster binding site [ion binding]; other site 1207075008840 YciI-like protein; Reviewed; Region: PRK12863 1207075008841 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1207075008842 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1207075008843 active site 1207075008844 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1207075008845 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1207075008846 active site 1207075008847 dimer interface [polypeptide binding]; other site 1207075008848 metal binding site [ion binding]; metal-binding site 1207075008849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075008850 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 1207075008851 NAD(P) binding site [chemical binding]; other site 1207075008852 catalytic residues [active] 1207075008853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075008854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075008855 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075008856 putative effector binding pocket; other site 1207075008857 dimerization interface [polypeptide binding]; other site 1207075008858 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1207075008859 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1207075008860 TM-ABC transporter signature motif; other site 1207075008861 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075008862 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1207075008863 TM-ABC transporter signature motif; other site 1207075008864 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1207075008865 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1207075008866 Walker A/P-loop; other site 1207075008867 ATP binding site [chemical binding]; other site 1207075008868 Q-loop/lid; other site 1207075008869 ABC transporter signature motif; other site 1207075008870 Walker B; other site 1207075008871 D-loop; other site 1207075008872 H-loop/switch region; other site 1207075008873 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1207075008874 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1207075008875 Walker A/P-loop; other site 1207075008876 ATP binding site [chemical binding]; other site 1207075008877 Q-loop/lid; other site 1207075008878 ABC transporter signature motif; other site 1207075008879 Walker B; other site 1207075008880 D-loop; other site 1207075008881 H-loop/switch region; other site 1207075008882 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1207075008883 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 1207075008884 putative ligand binding site [chemical binding]; other site 1207075008885 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1207075008886 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1207075008887 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075008888 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1207075008889 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075008890 NAD binding site [chemical binding]; other site 1207075008891 catalytic residues [active] 1207075008892 aspartate aminotransferase; Provisional; Region: PRK05764 1207075008893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075008894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075008895 homodimer interface [polypeptide binding]; other site 1207075008896 catalytic residue [active] 1207075008897 hypothetical protein; Provisional; Region: PRK07524 1207075008898 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1207075008899 PYR/PP interface [polypeptide binding]; other site 1207075008900 dimer interface [polypeptide binding]; other site 1207075008901 TPP binding site [chemical binding]; other site 1207075008902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1207075008903 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1207075008904 TPP-binding site [chemical binding]; other site 1207075008905 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1207075008906 CoA binding domain; Region: CoA_binding_2; pfam13380 1207075008907 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1207075008908 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1207075008909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075008910 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075008911 active site 1207075008912 enoyl-CoA hydratase; Provisional; Region: PRK06688 1207075008913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075008914 substrate binding site [chemical binding]; other site 1207075008915 oxyanion hole (OAH) forming residues; other site 1207075008916 trimer interface [polypeptide binding]; other site 1207075008917 S-methylmethionine transporter; Provisional; Region: PRK11387 1207075008918 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1207075008919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075008920 HAMP domain; Region: HAMP; pfam00672 1207075008921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075008922 dimer interface [polypeptide binding]; other site 1207075008923 phosphorylation site [posttranslational modification] 1207075008924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075008925 ATP binding site [chemical binding]; other site 1207075008926 Mg2+ binding site [ion binding]; other site 1207075008927 G-X-G motif; other site 1207075008928 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075008929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008930 active site 1207075008931 phosphorylation site [posttranslational modification] 1207075008932 intermolecular recognition site; other site 1207075008933 dimerization interface [polypeptide binding]; other site 1207075008934 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1207075008935 putative binding surface; other site 1207075008936 active site 1207075008937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1207075008938 substrate binding pocket [chemical binding]; other site 1207075008939 membrane-bound complex binding site; other site 1207075008940 hinge residues; other site 1207075008941 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075008942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075008943 DNA binding site [nucleotide binding] 1207075008944 Phytochelatin synthase; Region: Phytochelatin; pfam05023 1207075008945 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1207075008946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075008947 active site 1207075008948 phosphorylation site [posttranslational modification] 1207075008949 intermolecular recognition site; other site 1207075008950 dimerization interface [polypeptide binding]; other site 1207075008951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075008952 DNA binding site [nucleotide binding] 1207075008953 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1207075008954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075008955 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1207075008956 aldolase II superfamily protein; Provisional; Region: PRK07044 1207075008957 intersubunit interface [polypeptide binding]; other site 1207075008958 active site 1207075008959 Zn2+ binding site [ion binding]; other site 1207075008960 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075008961 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075008962 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1207075008963 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1207075008964 putative active site [active] 1207075008965 putative FMN binding site [chemical binding]; other site 1207075008966 putative substrate binding site [chemical binding]; other site 1207075008967 putative catalytic residue [active] 1207075008968 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1207075008969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075008970 non-specific DNA binding site [nucleotide binding]; other site 1207075008971 salt bridge; other site 1207075008972 sequence-specific DNA binding site [nucleotide binding]; other site 1207075008973 Cupin domain; Region: Cupin_2; pfam07883 1207075008974 Helix-turn-helix domain; Region: HTH_18; pfam12833 1207075008975 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075008976 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075008977 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075008978 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075008979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075008980 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075008981 Paraquat-inducible protein A; Region: PqiA; pfam04403 1207075008982 Paraquat-inducible protein A; Region: PqiA; pfam04403 1207075008983 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1207075008984 mce related protein; Region: MCE; pfam02470 1207075008985 mce related protein; Region: MCE; pfam02470 1207075008986 mce related protein; Region: MCE; pfam02470 1207075008987 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1207075008988 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1207075008989 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075008990 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1207075008991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075008992 dimer interface [polypeptide binding]; other site 1207075008993 conserved gate region; other site 1207075008994 ABC-ATPase subunit interface; other site 1207075008995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075008996 dimer interface [polypeptide binding]; other site 1207075008997 conserved gate region; other site 1207075008998 putative PBP binding loops; other site 1207075008999 ABC-ATPase subunit interface; other site 1207075009000 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075009001 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1207075009002 Walker A/P-loop; other site 1207075009003 ATP binding site [chemical binding]; other site 1207075009004 Q-loop/lid; other site 1207075009005 ABC transporter signature motif; other site 1207075009006 Walker B; other site 1207075009007 D-loop; other site 1207075009008 H-loop/switch region; other site 1207075009009 TOBE domain; Region: TOBE_2; pfam08402 1207075009010 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1207075009011 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1207075009012 active site 1207075009013 DNA binding site [nucleotide binding] 1207075009014 Int/Topo IB signature motif; other site 1207075009015 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1207075009016 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1207075009017 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1207075009018 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1207075009019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075009020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075009021 putative substrate translocation pore; other site 1207075009022 HPP family; Region: HPP; pfam04982 1207075009023 xanthine permease; Region: pbuX; TIGR03173 1207075009024 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1207075009025 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075009026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075009027 SurA N-terminal domain; Region: SurA_N; pfam09312 1207075009028 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1207075009029 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1207075009030 domain interface [polypeptide binding]; other site 1207075009031 putative active site [active] 1207075009032 catalytic site [active] 1207075009033 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1207075009034 domain interface [polypeptide binding]; other site 1207075009035 putative active site [active] 1207075009036 catalytic site [active] 1207075009037 putative transcriptional regulator; Provisional; Region: PRK11640 1207075009038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075009039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1207075009040 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1207075009041 hypothetical protein; Provisional; Region: PRK10621 1207075009042 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075009043 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1207075009044 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1207075009045 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1207075009046 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1207075009047 putative NADH binding site [chemical binding]; other site 1207075009048 putative active site [active] 1207075009049 nudix motif; other site 1207075009050 putative metal binding site [ion binding]; other site 1207075009051 enoyl-CoA hydratase; Provisional; Region: PRK06142 1207075009052 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075009053 substrate binding site [chemical binding]; other site 1207075009054 oxyanion hole (OAH) forming residues; other site 1207075009055 trimer interface [polypeptide binding]; other site 1207075009056 glycogen synthase; Provisional; Region: glgA; PRK00654 1207075009057 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1207075009058 ADP-binding pocket [chemical binding]; other site 1207075009059 homodimer interface [polypeptide binding]; other site 1207075009060 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1207075009061 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1207075009062 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1207075009063 catalytic site [active] 1207075009064 active site 1207075009065 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1207075009066 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1207075009067 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1207075009068 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1207075009069 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1207075009070 active site 1207075009071 catalytic site [active] 1207075009072 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1207075009073 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1207075009074 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1207075009075 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1207075009076 active site 1207075009077 catalytic site [active] 1207075009078 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1207075009079 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1207075009080 putative catalytic site [active] 1207075009081 putative metal binding site [ion binding]; other site 1207075009082 putative phosphate binding site [ion binding]; other site 1207075009083 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1207075009084 Autotransporter beta-domain; Region: Autotransporter; smart00869 1207075009085 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1207075009086 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1207075009087 glycogen branching enzyme; Provisional; Region: PRK05402 1207075009088 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1207075009089 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1207075009090 active site 1207075009091 catalytic site [active] 1207075009092 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1207075009093 trehalose synthase; Region: treS_nterm; TIGR02456 1207075009094 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1207075009095 active site 1207075009096 catalytic site [active] 1207075009097 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1207075009098 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1207075009099 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1207075009100 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1207075009101 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1207075009102 active site 1207075009103 homodimer interface [polypeptide binding]; other site 1207075009104 catalytic site [active] 1207075009105 acceptor binding site [chemical binding]; other site 1207075009106 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1207075009107 MgtC family; Region: MgtC; pfam02308 1207075009108 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 1207075009109 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1207075009110 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1207075009111 4Fe-4S binding domain; Region: Fer4_3; pfam12798 1207075009112 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1207075009113 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075009114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075009115 DNA-binding site [nucleotide binding]; DNA binding site 1207075009116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075009117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075009118 homodimer interface [polypeptide binding]; other site 1207075009119 catalytic residue [active] 1207075009120 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1207075009121 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1207075009122 Peptidase M35 family; Region: M35_like; cl03449 1207075009123 active site 1207075009124 Zn binding site [ion binding]; other site 1207075009125 short chain dehydrogenase; Provisional; Region: PRK06123 1207075009126 classical (c) SDRs; Region: SDR_c; cd05233 1207075009127 NAD(P) binding site [chemical binding]; other site 1207075009128 active site 1207075009129 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1207075009130 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1207075009131 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1207075009132 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075009133 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075009134 metal binding site [ion binding]; metal-binding site 1207075009135 active site 1207075009136 I-site; other site 1207075009137 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075009138 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1207075009139 Non-repetitive/WGA-negative nucleoporin C-terminal; Region: Nucleoporin_C; pfam03177 1207075009140 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1207075009141 Protein export membrane protein; Region: SecD_SecF; cl14618 1207075009142 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1207075009143 Protein export membrane protein; Region: SecD_SecF; cl14618 1207075009144 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1207075009145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075009146 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075009147 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1207075009148 dimer interface [polypeptide binding]; other site 1207075009149 catalytic triad [active] 1207075009150 peroxidatic and resolving cysteines [active] 1207075009151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1207075009152 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1207075009153 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1207075009154 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1207075009155 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1207075009156 MoxR-like ATPases [General function prediction only]; Region: COG0714 1207075009157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075009158 ATP binding site [chemical binding]; other site 1207075009159 Walker A motif; other site 1207075009160 Walker B motif; other site 1207075009161 arginine finger; other site 1207075009162 Protein of unknown function DUF58; Region: DUF58; pfam01882 1207075009163 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1207075009164 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1207075009165 metal ion-dependent adhesion site (MIDAS); other site 1207075009166 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1207075009167 metal ion-dependent adhesion site (MIDAS); other site 1207075009168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075009169 TPR repeat; Region: TPR_11; pfam13414 1207075009170 binding surface 1207075009171 TPR motif; other site 1207075009172 Oxygen tolerance; Region: BatD; pfam13584 1207075009173 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1207075009174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075009175 motif II; other site 1207075009176 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075009177 Sulfatase; Region: Sulfatase; pfam00884 1207075009178 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1207075009179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075009180 S-adenosylmethionine binding site [chemical binding]; other site 1207075009181 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1207075009182 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 1207075009183 HEAT repeats; Region: HEAT_2; pfam13646 1207075009184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075009185 binding surface 1207075009186 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1207075009187 TPR motif; other site 1207075009188 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1207075009189 universal stress protein UspE; Provisional; Region: PRK11175 1207075009190 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075009191 Ligand Binding Site [chemical binding]; other site 1207075009192 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075009193 Ligand Binding Site [chemical binding]; other site 1207075009194 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1207075009195 BNR repeat-like domain; Region: BNR_2; pfam13088 1207075009196 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1207075009197 Sulfatase; Region: Sulfatase; pfam00884 1207075009198 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1207075009199 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1207075009200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075009201 Coenzyme A binding pocket [chemical binding]; other site 1207075009202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075009203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009204 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075009205 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1207075009206 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1207075009207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075009208 DNA-binding site [nucleotide binding]; DNA binding site 1207075009209 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075009210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075009211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075009212 homodimer interface [polypeptide binding]; other site 1207075009213 catalytic residue [active] 1207075009214 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1207075009215 Cupin domain; Region: Cupin_2; pfam07883 1207075009216 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1207075009217 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1207075009218 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1207075009219 active site 1207075009220 catalytic residues [active] 1207075009221 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1207075009222 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1207075009223 MoxR-like ATPases [General function prediction only]; Region: COG0714 1207075009224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075009225 Walker A motif; other site 1207075009226 ATP binding site [chemical binding]; other site 1207075009227 Walker B motif; other site 1207075009228 arginine finger; other site 1207075009229 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1207075009230 Protein of unknown function DUF58; Region: DUF58; pfam01882 1207075009231 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1207075009232 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1207075009233 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1207075009234 metal ion-dependent adhesion site (MIDAS); other site 1207075009235 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1207075009236 metal ion-dependent adhesion site (MIDAS); other site 1207075009237 TPR repeat; Region: TPR_11; pfam13414 1207075009238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075009239 binding surface 1207075009240 Oxygen tolerance; Region: BatD; pfam13584 1207075009241 exonuclease subunit SbcD; Provisional; Region: PRK10966 1207075009242 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1207075009243 active site 1207075009244 metal binding site [ion binding]; metal-binding site 1207075009245 DNA binding site [nucleotide binding] 1207075009246 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1207075009247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075009248 AAA domain; Region: AAA_23; pfam13476 1207075009249 Walker A/P-loop; other site 1207075009250 ATP binding site [chemical binding]; other site 1207075009251 Q-loop/lid; other site 1207075009252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075009253 ABC transporter signature motif; other site 1207075009254 Walker B; other site 1207075009255 D-loop; other site 1207075009256 H-loop/switch region; other site 1207075009257 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075009258 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1207075009259 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 1207075009260 putative N-terminal domain interface [polypeptide binding]; other site 1207075009261 putative dimer interface [polypeptide binding]; other site 1207075009262 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075009263 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1207075009264 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075009265 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1207075009266 dimer interface [polypeptide binding]; other site 1207075009267 NADP binding site [chemical binding]; other site 1207075009268 catalytic residues [active] 1207075009269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1207075009270 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1207075009271 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075009272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075009273 putative substrate translocation pore; other site 1207075009274 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1207075009275 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075009276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075009277 DNA-binding site [nucleotide binding]; DNA binding site 1207075009278 FCD domain; Region: FCD; pfam07729 1207075009279 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1207075009280 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1207075009281 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1207075009282 putative active site [active] 1207075009283 aminopeptidase N; Provisional; Region: pepN; PRK14015 1207075009284 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1207075009285 active site 1207075009286 Zn binding site [ion binding]; other site 1207075009287 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1207075009288 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1207075009289 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 1207075009290 Rhomboid family; Region: Rhomboid; pfam01694 1207075009291 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 1207075009292 active site 1207075009293 metal binding site [ion binding]; metal-binding site 1207075009294 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1207075009295 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1207075009296 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1207075009297 Predicted flavoprotein [General function prediction only]; Region: COG0431 1207075009298 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075009299 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1207075009300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075009302 dimerization interface [polypeptide binding]; other site 1207075009303 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075009304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075009305 Coenzyme A binding pocket [chemical binding]; other site 1207075009306 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1207075009307 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1207075009308 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1207075009309 homodimer interface [polypeptide binding]; other site 1207075009310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075009311 catalytic residue [active] 1207075009312 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1207075009313 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1207075009314 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1207075009315 active site 1207075009316 catalytic site [active] 1207075009317 substrate binding site [chemical binding]; other site 1207075009318 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1207075009319 RNA/DNA hybrid binding site [nucleotide binding]; other site 1207075009320 active site 1207075009321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075009322 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1207075009323 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1207075009324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075009325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075009326 catalytic residue [active] 1207075009327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1207075009328 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1207075009329 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1207075009330 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1207075009331 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1207075009332 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1207075009333 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1207075009334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075009335 dimer interface [polypeptide binding]; other site 1207075009336 conserved gate region; other site 1207075009337 putative PBP binding loops; other site 1207075009338 ABC-ATPase subunit interface; other site 1207075009339 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1207075009340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075009341 dimer interface [polypeptide binding]; other site 1207075009342 conserved gate region; other site 1207075009343 putative PBP binding loops; other site 1207075009344 ABC-ATPase subunit interface; other site 1207075009345 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1207075009346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1207075009347 Walker A/P-loop; other site 1207075009348 ATP binding site [chemical binding]; other site 1207075009349 Q-loop/lid; other site 1207075009350 ABC transporter signature motif; other site 1207075009351 Walker B; other site 1207075009352 D-loop; other site 1207075009353 H-loop/switch region; other site 1207075009354 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1207075009355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1207075009356 Walker A/P-loop; other site 1207075009357 ATP binding site [chemical binding]; other site 1207075009358 Q-loop/lid; other site 1207075009359 ABC transporter signature motif; other site 1207075009360 Walker B; other site 1207075009361 D-loop; other site 1207075009362 H-loop/switch region; other site 1207075009363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1207075009364 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1207075009365 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1207075009366 NAD binding site [chemical binding]; other site 1207075009367 homotetramer interface [polypeptide binding]; other site 1207075009368 homodimer interface [polypeptide binding]; other site 1207075009369 substrate binding site [chemical binding]; other site 1207075009370 active site 1207075009371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075009372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009373 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1207075009374 putative dimerization interface [polypeptide binding]; other site 1207075009375 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1207075009376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1207075009377 putative metal binding site [ion binding]; other site 1207075009378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075009379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075009380 metal binding site [ion binding]; metal-binding site 1207075009381 active site 1207075009382 I-site; other site 1207075009383 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075009384 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1207075009385 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1207075009386 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075009387 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075009388 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1207075009389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075009390 catalytic loop [active] 1207075009391 iron binding site [ion binding]; other site 1207075009392 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1207075009393 NnrS protein; Region: NnrS; pfam05940 1207075009394 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1207075009395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075009396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075009397 DNA binding residues [nucleotide binding] 1207075009398 fec operon regulator FecR; Reviewed; Region: PRK09774 1207075009399 FecR protein; Region: FecR; pfam04773 1207075009400 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1207075009401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075009402 N-terminal plug; other site 1207075009403 ligand-binding site [chemical binding]; other site 1207075009404 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1207075009405 dimer interface [polypeptide binding]; other site 1207075009406 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075009407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075009408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075009409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075009410 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075009411 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075009412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075009413 DNA-binding site [nucleotide binding]; DNA binding site 1207075009414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075009415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075009416 homodimer interface [polypeptide binding]; other site 1207075009417 catalytic residue [active] 1207075009418 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075009419 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075009420 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1207075009421 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1207075009422 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1207075009423 DNA binding site [nucleotide binding] 1207075009424 active site 1207075009425 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1207075009426 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1207075009427 tetramer interface [polypeptide binding]; other site 1207075009428 active site 1207075009429 Mg2+/Mn2+ binding site [ion binding]; other site 1207075009430 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1207075009431 endonuclease III; Region: ENDO3c; smart00478 1207075009432 minor groove reading motif; other site 1207075009433 helix-hairpin-helix signature motif; other site 1207075009434 substrate binding pocket [chemical binding]; other site 1207075009435 active site 1207075009436 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075009437 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075009438 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1207075009439 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1207075009440 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075009441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009442 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075009443 dimerization interface [polypeptide binding]; other site 1207075009444 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1207075009445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075009446 N-terminal plug; other site 1207075009447 ligand-binding site [chemical binding]; other site 1207075009448 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1207075009449 active site 1207075009450 dinuclear metal binding site [ion binding]; other site 1207075009451 dimerization interface [polypeptide binding]; other site 1207075009452 universal stress protein UspE; Provisional; Region: PRK11175 1207075009453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075009454 Ligand Binding Site [chemical binding]; other site 1207075009455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075009456 Ligand Binding Site [chemical binding]; other site 1207075009457 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1207075009458 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1207075009459 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1207075009460 substrate binding site [chemical binding]; other site 1207075009461 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1207075009462 substrate binding site [chemical binding]; other site 1207075009463 ligand binding site [chemical binding]; other site 1207075009464 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1207075009465 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1207075009466 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075009467 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1207075009468 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1207075009469 serine transporter; Region: stp; TIGR00814 1207075009470 active site 1 [active] 1207075009471 dimer interface [polypeptide binding]; other site 1207075009472 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1207075009473 hexamer interface [polypeptide binding]; other site 1207075009474 active site 2 [active] 1207075009475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075009476 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1207075009477 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1207075009478 putative ligand binding site [chemical binding]; other site 1207075009479 NAD binding site [chemical binding]; other site 1207075009480 catalytic site [active] 1207075009481 Phosphotransferase enzyme family; Region: APH; pfam01636 1207075009482 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1207075009483 putative active site [active] 1207075009484 putative substrate binding site [chemical binding]; other site 1207075009485 ATP binding site [chemical binding]; other site 1207075009486 short chain dehydrogenase; Provisional; Region: PRK07035 1207075009487 classical (c) SDRs; Region: SDR_c; cd05233 1207075009488 NAD(P) binding site [chemical binding]; other site 1207075009489 active site 1207075009490 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1207075009491 PAS domain; Region: PAS_8; pfam13188 1207075009492 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075009493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075009494 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075009495 putative active site [active] 1207075009496 heme pocket [chemical binding]; other site 1207075009497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075009498 putative active site [active] 1207075009499 heme pocket [chemical binding]; other site 1207075009500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075009501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075009502 DNA binding residues [nucleotide binding] 1207075009503 dimerization interface [polypeptide binding]; other site 1207075009504 allantoate amidohydrolase; Reviewed; Region: PRK12893 1207075009505 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1207075009506 active site 1207075009507 metal binding site [ion binding]; metal-binding site 1207075009508 dimer interface [polypeptide binding]; other site 1207075009509 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1207075009510 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075009511 Na binding site [ion binding]; other site 1207075009512 putative substrate binding site [chemical binding]; other site 1207075009513 phenylhydantoinase; Validated; Region: PRK08323 1207075009514 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1207075009515 tetramer interface [polypeptide binding]; other site 1207075009516 active site 1207075009517 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1207075009518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075009519 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1207075009520 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1207075009521 homodimer interface [polypeptide binding]; other site 1207075009522 active site 1207075009523 FMN binding site [chemical binding]; other site 1207075009524 substrate binding site [chemical binding]; other site 1207075009525 4Fe-4S binding domain; Region: Fer4; cl02805 1207075009526 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1207075009527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075009528 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1207075009529 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075009530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075009531 extended (e) SDRs; Region: SDR_e; cd08946 1207075009532 NAD(P) binding site [chemical binding]; other site 1207075009533 active site 1207075009534 substrate binding site [chemical binding]; other site 1207075009535 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1207075009536 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1207075009537 active site 1207075009538 catalytic residues [active] 1207075009539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1207075009540 PAS domain S-box; Region: sensory_box; TIGR00229 1207075009541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075009542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075009543 dimer interface [polypeptide binding]; other site 1207075009544 phosphorylation site [posttranslational modification] 1207075009545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075009546 ATP binding site [chemical binding]; other site 1207075009547 Mg2+ binding site [ion binding]; other site 1207075009548 G-X-G motif; other site 1207075009549 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075009550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075009551 active site 1207075009552 phosphorylation site [posttranslational modification] 1207075009553 intermolecular recognition site; other site 1207075009554 dimerization interface [polypeptide binding]; other site 1207075009555 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1207075009556 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1207075009557 putative active site [active] 1207075009558 metal binding site [ion binding]; metal-binding site 1207075009559 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1207075009560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075009561 FeS/SAM binding site; other site 1207075009562 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1207075009563 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1207075009564 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1207075009565 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1207075009566 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1207075009567 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075009568 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075009569 NAD(P) binding site [chemical binding]; other site 1207075009570 catalytic residues [active] 1207075009571 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1207075009572 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1207075009573 dimer interface [polypeptide binding]; other site 1207075009574 Trp docking motif [polypeptide binding]; other site 1207075009575 active site 1207075009576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1207075009577 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1207075009578 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1207075009579 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075009580 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075009581 substrate binding pocket [chemical binding]; other site 1207075009582 membrane-bound complex binding site; other site 1207075009583 hinge residues; other site 1207075009584 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1207075009585 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1207075009586 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1207075009587 ligand binding site [chemical binding]; other site 1207075009588 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1207075009589 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1207075009590 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1207075009591 structural tetrad; other site 1207075009592 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1207075009593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075009594 Walker A/P-loop; other site 1207075009595 ATP binding site [chemical binding]; other site 1207075009596 Q-loop/lid; other site 1207075009597 ABC transporter signature motif; other site 1207075009598 Walker B; other site 1207075009599 D-loop; other site 1207075009600 H-loop/switch region; other site 1207075009601 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 1207075009602 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1207075009603 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1207075009604 active site residue [active] 1207075009605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075009606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075009607 active site 1207075009608 phosphorylation site [posttranslational modification] 1207075009609 intermolecular recognition site; other site 1207075009610 dimerization interface [polypeptide binding]; other site 1207075009611 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075009612 DNA binding residues [nucleotide binding] 1207075009613 dimerization interface [polypeptide binding]; other site 1207075009614 PAS fold; Region: PAS_7; pfam12860 1207075009615 PAS fold; Region: PAS_7; pfam12860 1207075009616 PAS fold; Region: PAS_4; pfam08448 1207075009617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075009618 putative active site [active] 1207075009619 heme pocket [chemical binding]; other site 1207075009620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075009621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075009622 dimer interface [polypeptide binding]; other site 1207075009623 phosphorylation site [posttranslational modification] 1207075009624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075009625 ATP binding site [chemical binding]; other site 1207075009626 Mg2+ binding site [ion binding]; other site 1207075009627 G-X-G motif; other site 1207075009628 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075009629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075009630 active site 1207075009631 phosphorylation site [posttranslational modification] 1207075009632 intermolecular recognition site; other site 1207075009633 dimerization interface [polypeptide binding]; other site 1207075009634 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1207075009635 FIST N domain; Region: FIST; pfam08495 1207075009636 FIST C domain; Region: FIST_C; pfam10442 1207075009637 Gram-negative porin; Region: Porin_4; pfam13609 1207075009638 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075009639 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1207075009640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075009641 putative DNA binding site [nucleotide binding]; other site 1207075009642 dimerization interface [polypeptide binding]; other site 1207075009643 putative Zn2+ binding site [ion binding]; other site 1207075009644 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1207075009645 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075009646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075009647 putative DNA binding site [nucleotide binding]; other site 1207075009648 putative Zn2+ binding site [ion binding]; other site 1207075009649 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075009650 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1207075009651 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1207075009652 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1207075009653 tetramer interface [polypeptide binding]; other site 1207075009654 TPP-binding site [chemical binding]; other site 1207075009655 heterodimer interface [polypeptide binding]; other site 1207075009656 phosphorylation loop region [posttranslational modification] 1207075009657 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1207075009658 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1207075009659 alpha subunit interface [polypeptide binding]; other site 1207075009660 TPP binding site [chemical binding]; other site 1207075009661 heterodimer interface [polypeptide binding]; other site 1207075009662 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1207075009663 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1207075009664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075009665 E3 interaction surface; other site 1207075009666 lipoyl attachment site [posttranslational modification]; other site 1207075009667 e3 binding domain; Region: E3_binding; pfam02817 1207075009668 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1207075009669 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1207075009670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075009671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1207075009672 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1207075009673 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1207075009674 homodimer interface [polypeptide binding]; other site 1207075009675 substrate-cofactor binding pocket; other site 1207075009676 catalytic residue [active] 1207075009677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075009678 dimerization interface [polypeptide binding]; other site 1207075009679 putative DNA binding site [nucleotide binding]; other site 1207075009680 putative Zn2+ binding site [ion binding]; other site 1207075009681 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1207075009682 Cytochrome P450; Region: p450; cl12078 1207075009683 MEKHLA domain; Region: MEKHLA; pfam08670 1207075009684 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1207075009685 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1207075009686 active site 1207075009687 Zn binding site [ion binding]; other site 1207075009688 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1207075009689 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075009690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075009691 PAS fold; Region: PAS_3; pfam08447 1207075009692 putative active site [active] 1207075009693 heme pocket [chemical binding]; other site 1207075009694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075009695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075009696 metal binding site [ion binding]; metal-binding site 1207075009697 active site 1207075009698 I-site; other site 1207075009699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1207075009700 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1207075009701 DNA binding residues [nucleotide binding] 1207075009702 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1207075009703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075009704 PAS domain; Region: PAS_9; pfam13426 1207075009705 putative active site [active] 1207075009706 heme pocket [chemical binding]; other site 1207075009707 SnoaL-like domain; Region: SnoaL_2; pfam12680 1207075009708 classical (c) SDRs; Region: SDR_c; cd05233 1207075009709 NAD(P) binding site [chemical binding]; other site 1207075009710 active site 1207075009711 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1207075009712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075009713 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1207075009714 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1207075009715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075009716 S-adenosylmethionine binding site [chemical binding]; other site 1207075009717 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1207075009718 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1207075009719 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1207075009720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075009721 DNA-binding site [nucleotide binding]; DNA binding site 1207075009722 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1207075009723 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1207075009724 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1207075009725 tetramer interface [polypeptide binding]; other site 1207075009726 active site 1207075009727 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1207075009728 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075009729 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075009730 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075009731 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075009732 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075009733 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075009734 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075009735 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 1207075009736 Ca2+ binding site [ion binding]; other site 1207075009737 PilZ domain; Region: PilZ; pfam07238 1207075009738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075009739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075009740 active site 1207075009741 phosphorylation site [posttranslational modification] 1207075009742 intermolecular recognition site; other site 1207075009743 dimerization interface [polypeptide binding]; other site 1207075009744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075009745 DNA binding residues [nucleotide binding] 1207075009746 dimerization interface [polypeptide binding]; other site 1207075009747 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1207075009748 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1207075009749 TrkA-N domain; Region: TrkA_N; pfam02254 1207075009750 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1207075009751 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1207075009752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075009753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075009755 dimerization interface [polypeptide binding]; other site 1207075009756 choline dehydrogenase; Validated; Region: PRK02106 1207075009757 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1207075009758 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075009759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075009760 putative substrate translocation pore; other site 1207075009761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075009762 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075009763 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1207075009764 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1207075009765 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1207075009766 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075009767 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075009768 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1207075009769 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075009770 Walker A/P-loop; other site 1207075009771 ATP binding site [chemical binding]; other site 1207075009772 Q-loop/lid; other site 1207075009773 ABC transporter signature motif; other site 1207075009774 Walker B; other site 1207075009775 D-loop; other site 1207075009776 H-loop/switch region; other site 1207075009777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075009778 dimer interface [polypeptide binding]; other site 1207075009779 conserved gate region; other site 1207075009780 putative PBP binding loops; other site 1207075009781 ABC-ATPase subunit interface; other site 1207075009782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075009783 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075009784 substrate binding pocket [chemical binding]; other site 1207075009785 membrane-bound complex binding site; other site 1207075009786 hinge residues; other site 1207075009787 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1207075009788 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1207075009789 Bacterial transcriptional regulator; Region: IclR; pfam01614 1207075009790 PAS domain; Region: PAS; smart00091 1207075009791 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1207075009792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075009793 Walker B motif; other site 1207075009794 arginine finger; other site 1207075009795 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075009796 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075009797 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075009798 EamA-like transporter family; Region: EamA; pfam00892 1207075009799 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075009800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075009801 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1207075009802 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1207075009803 non-specific DNA interactions [nucleotide binding]; other site 1207075009804 DNA binding site [nucleotide binding] 1207075009805 sequence specific DNA binding site [nucleotide binding]; other site 1207075009806 putative cAMP binding site [chemical binding]; other site 1207075009807 Bacterial transcriptional regulator; Region: IclR; pfam01614 1207075009808 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1207075009809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075009810 putative substrate translocation pore; other site 1207075009811 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075009812 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075009813 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1207075009814 active site 1207075009815 catalytic residues [active] 1207075009816 metal binding site [ion binding]; metal-binding site 1207075009817 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1207075009818 NHL repeat; Region: NHL; pfam01436 1207075009819 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1207075009820 Citrate transporter; Region: CitMHS; pfam03600 1207075009821 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1207075009822 DNA topoisomerase III; Provisional; Region: PRK07726 1207075009823 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1207075009824 active site 1207075009825 putative interdomain interaction site [polypeptide binding]; other site 1207075009826 putative metal-binding site [ion binding]; other site 1207075009827 putative nucleotide binding site [chemical binding]; other site 1207075009828 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1207075009829 domain I; other site 1207075009830 DNA binding groove [nucleotide binding] 1207075009831 phosphate binding site [ion binding]; other site 1207075009832 domain II; other site 1207075009833 domain III; other site 1207075009834 nucleotide binding site [chemical binding]; other site 1207075009835 catalytic site [active] 1207075009836 domain IV; other site 1207075009837 Predicted acetyltransferase [General function prediction only]; Region: COG5628 1207075009838 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075009839 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1207075009840 NAD(P) binding site [chemical binding]; other site 1207075009841 catalytic residues [active] 1207075009842 Predicted membrane protein [Function unknown]; Region: COG2259 1207075009843 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075009844 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1207075009845 putative active site [active] 1207075009846 catalytic triad [active] 1207075009847 putative dimer interface [polypeptide binding]; other site 1207075009848 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075009849 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075009850 conserved cys residue [active] 1207075009851 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075009852 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1207075009853 C-terminal domain interface [polypeptide binding]; other site 1207075009854 GSH binding site (G-site) [chemical binding]; other site 1207075009855 dimer interface [polypeptide binding]; other site 1207075009856 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1207075009857 N-terminal domain interface [polypeptide binding]; other site 1207075009858 dimer interface [polypeptide binding]; other site 1207075009859 substrate binding pocket (H-site) [chemical binding]; other site 1207075009860 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1207075009861 Peptidase family U32; Region: Peptidase_U32; pfam01136 1207075009862 Collagenase; Region: DUF3656; pfam12392 1207075009863 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1207075009864 homotrimer interaction site [polypeptide binding]; other site 1207075009865 putative active site [active] 1207075009866 PAS fold; Region: PAS_4; pfam08448 1207075009867 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075009868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075009869 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1207075009870 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1207075009871 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1207075009872 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1207075009873 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1207075009874 inhibitor site; inhibition site 1207075009875 active site 1207075009876 dimer interface [polypeptide binding]; other site 1207075009877 catalytic residue [active] 1207075009878 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075009879 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1207075009880 dimer interface [polypeptide binding]; other site 1207075009881 NADP binding site [chemical binding]; other site 1207075009882 catalytic residues [active] 1207075009883 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1207075009884 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075009885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075009886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075009887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075009888 putative substrate translocation pore; other site 1207075009889 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1207075009890 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1207075009891 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1207075009892 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075009893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075009894 NAD(P) binding site [chemical binding]; other site 1207075009895 active site 1207075009896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075009897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009898 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075009899 putative effector binding pocket; other site 1207075009900 dimerization interface [polypeptide binding]; other site 1207075009901 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075009902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075009903 DNA binding residues [nucleotide binding] 1207075009904 dimerization interface [polypeptide binding]; other site 1207075009905 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075009906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075009907 Walker A/P-loop; other site 1207075009908 ATP binding site [chemical binding]; other site 1207075009909 Q-loop/lid; other site 1207075009910 ABC transporter signature motif; other site 1207075009911 Walker B; other site 1207075009912 D-loop; other site 1207075009913 H-loop/switch region; other site 1207075009914 TOBE domain; Region: TOBE_2; pfam08402 1207075009915 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075009916 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075009917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075009918 dimer interface [polypeptide binding]; other site 1207075009919 conserved gate region; other site 1207075009920 putative PBP binding loops; other site 1207075009921 ABC-ATPase subunit interface; other site 1207075009922 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075009923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075009924 dimer interface [polypeptide binding]; other site 1207075009925 conserved gate region; other site 1207075009926 putative PBP binding loops; other site 1207075009927 ABC-ATPase subunit interface; other site 1207075009928 betaine aldehyde dehydrogenase; Region: PLN02467 1207075009929 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1207075009930 NAD(P) binding site [chemical binding]; other site 1207075009931 catalytic residues [active] 1207075009932 catalytic residues [active] 1207075009933 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1207075009934 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1207075009935 putative active site [active] 1207075009936 putative metal binding site [ion binding]; other site 1207075009937 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1207075009938 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1207075009939 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1207075009940 putative NAD(P) binding site [chemical binding]; other site 1207075009941 putative substrate binding site [chemical binding]; other site 1207075009942 catalytic Zn binding site [ion binding]; other site 1207075009943 structural Zn binding site [ion binding]; other site 1207075009944 dimer interface [polypeptide binding]; other site 1207075009945 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1207075009946 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1207075009947 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1207075009948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1207075009949 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1207075009950 Ligand binding site; other site 1207075009951 Putative Catalytic site; other site 1207075009952 DXD motif; other site 1207075009953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075009954 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1207075009955 putative NAD(P) binding site [chemical binding]; other site 1207075009956 active site 1207075009957 putative substrate binding site [chemical binding]; other site 1207075009958 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1207075009959 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1207075009960 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1207075009961 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1207075009962 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1207075009963 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1207075009964 dimer interface [polypeptide binding]; other site 1207075009965 motif 1; other site 1207075009966 active site 1207075009967 motif 2; other site 1207075009968 motif 3; other site 1207075009969 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1207075009970 anticodon binding site; other site 1207075009971 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1207075009972 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1207075009973 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1207075009974 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1207075009975 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1207075009976 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1207075009977 putative molybdopterin cofactor binding site [chemical binding]; other site 1207075009978 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1207075009979 putative molybdopterin cofactor binding site; other site 1207075009980 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1207075009981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075009982 FeS/SAM binding site; other site 1207075009983 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1207075009984 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1207075009985 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1207075009986 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1207075009987 dimer interface [polypeptide binding]; other site 1207075009988 putative functional site; other site 1207075009989 putative MPT binding site; other site 1207075009990 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1207075009991 MPT binding site; other site 1207075009992 trimer interface [polypeptide binding]; other site 1207075009993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075009994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075009995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075009996 dimerization interface [polypeptide binding]; other site 1207075009997 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 1207075009998 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1207075009999 trimer interface [polypeptide binding]; other site 1207075010000 dimer interface [polypeptide binding]; other site 1207075010001 putative active site [active] 1207075010002 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1207075010003 MoaE interaction surface [polypeptide binding]; other site 1207075010004 MoeB interaction surface [polypeptide binding]; other site 1207075010005 thiocarboxylated glycine; other site 1207075010006 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1207075010007 MoaE homodimer interface [polypeptide binding]; other site 1207075010008 MoaD interaction [polypeptide binding]; other site 1207075010009 active site residues [active] 1207075010010 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1207075010011 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1207075010012 Chromate transporter; Region: Chromate_transp; pfam02417 1207075010013 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075010014 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075010015 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1207075010016 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1207075010017 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1207075010018 ornithine decarboxylase; Provisional; Region: PRK13578 1207075010019 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1207075010020 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1207075010021 homodimer interface [polypeptide binding]; other site 1207075010022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075010023 catalytic residue [active] 1207075010024 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1207075010025 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1207075010026 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075010027 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075010028 ligand binding site [chemical binding]; other site 1207075010029 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1207075010030 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1207075010031 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1207075010032 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1207075010033 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1207075010034 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1207075010035 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1207075010036 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1207075010037 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1207075010038 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1207075010039 PAAR motif; Region: PAAR_motif; pfam05488 1207075010040 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1207075010041 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1207075010042 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1207075010043 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1207075010044 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1207075010045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1207075010046 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1207075010047 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1207075010048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075010049 Walker A motif; other site 1207075010050 ATP binding site [chemical binding]; other site 1207075010051 Walker B motif; other site 1207075010052 arginine finger; other site 1207075010053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075010054 Walker A motif; other site 1207075010055 ATP binding site [chemical binding]; other site 1207075010056 Walker B motif; other site 1207075010057 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1207075010058 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1207075010059 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075010060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075010061 ligand binding site [chemical binding]; other site 1207075010062 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1207075010063 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1207075010064 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1207075010065 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1207075010066 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1207075010067 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1207075010068 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1207075010069 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1207075010070 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1207075010071 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075010072 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1207075010073 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075010074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010075 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1207075010076 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1207075010077 Autotransporter beta-domain; Region: Autotransporter; smart00869 1207075010078 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1207075010079 Predicted integral membrane protein [Function unknown]; Region: COG5616 1207075010080 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1207075010081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075010082 non-specific DNA binding site [nucleotide binding]; other site 1207075010083 salt bridge; other site 1207075010084 sequence-specific DNA binding site [nucleotide binding]; other site 1207075010085 Cupin domain; Region: Cupin_2; pfam07883 1207075010086 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075010087 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075010088 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1207075010089 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1207075010090 NAD(P) binding site [chemical binding]; other site 1207075010091 catalytic residues [active] 1207075010092 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075010093 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1207075010094 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075010095 Peptidase C26; Region: Peptidase_C26; pfam07722 1207075010096 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1207075010097 catalytic triad [active] 1207075010098 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1207075010099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075010100 Walker A/P-loop; other site 1207075010101 ATP binding site [chemical binding]; other site 1207075010102 Q-loop/lid; other site 1207075010103 ABC transporter signature motif; other site 1207075010104 Walker B; other site 1207075010105 D-loop; other site 1207075010106 H-loop/switch region; other site 1207075010107 TOBE domain; Region: TOBE_2; pfam08402 1207075010108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010109 dimer interface [polypeptide binding]; other site 1207075010110 conserved gate region; other site 1207075010111 putative PBP binding loops; other site 1207075010112 ABC-ATPase subunit interface; other site 1207075010113 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075010114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010115 dimer interface [polypeptide binding]; other site 1207075010116 conserved gate region; other site 1207075010117 putative PBP binding loops; other site 1207075010118 ABC-ATPase subunit interface; other site 1207075010119 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075010120 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075010121 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1207075010122 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1207075010123 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1207075010124 L-lactate permease; Region: Lactate_perm; cl00701 1207075010125 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1207075010126 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1207075010127 FAD binding domain; Region: FAD_binding_4; pfam01565 1207075010128 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1207075010129 FAD binding domain; Region: FAD_binding_4; pfam01565 1207075010130 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1207075010131 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1207075010132 Cysteine-rich domain; Region: CCG; pfam02754 1207075010133 Cysteine-rich domain; Region: CCG; pfam02754 1207075010134 Domain of unknown function (DUF336); Region: DUF336; cl01249 1207075010135 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1207075010136 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075010137 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1207075010138 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1207075010139 dimer interface [polypeptide binding]; other site 1207075010140 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1207075010141 catalytic triad [active] 1207075010142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075010143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075010144 active site 1207075010145 catalytic tetrad [active] 1207075010146 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1207075010147 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1207075010148 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1207075010149 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1207075010150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075010151 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075010152 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075010153 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1207075010154 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1207075010155 PQQ-like domain; Region: PQQ_2; pfam13360 1207075010156 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1207075010157 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1207075010158 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1207075010159 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1207075010160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075010161 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075010162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075010163 Transposase; Region: HTH_Tnp_1; pfam01527 1207075010164 putative transposase OrfB; Reviewed; Region: PHA02517 1207075010165 HTH-like domain; Region: HTH_21; pfam13276 1207075010166 Integrase core domain; Region: rve; pfam00665 1207075010167 Integrase core domain; Region: rve_3; pfam13683 1207075010168 betaine aldehyde dehydrogenase; Region: PLN02467 1207075010169 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1207075010170 NAD(P) binding site [chemical binding]; other site 1207075010171 catalytic residues [active] 1207075010172 catalytic residues [active] 1207075010173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075010174 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1207075010175 NAD(P) binding site [chemical binding]; other site 1207075010176 catalytic residues [active] 1207075010177 Phosphotransferase enzyme family; Region: APH; pfam01636 1207075010178 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1207075010179 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1207075010180 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1207075010181 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1207075010182 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1207075010183 active site 1207075010184 TDP-binding site; other site 1207075010185 acceptor substrate-binding pocket; other site 1207075010186 homodimer interface [polypeptide binding]; other site 1207075010187 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075010188 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1207075010189 Walker A/P-loop; other site 1207075010190 ATP binding site [chemical binding]; other site 1207075010191 Q-loop/lid; other site 1207075010192 ABC transporter signature motif; other site 1207075010193 Walker B; other site 1207075010194 D-loop; other site 1207075010195 H-loop/switch region; other site 1207075010196 TOBE domain; Region: TOBE_2; pfam08402 1207075010197 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075010198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010199 dimer interface [polypeptide binding]; other site 1207075010200 conserved gate region; other site 1207075010201 putative PBP binding loops; other site 1207075010202 ABC-ATPase subunit interface; other site 1207075010203 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075010204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010205 putative PBP binding loops; other site 1207075010206 ABC-ATPase subunit interface; other site 1207075010207 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075010208 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075010209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075010210 DNA-binding site [nucleotide binding]; DNA binding site 1207075010211 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075010212 FCD domain; Region: FCD; pfam07729 1207075010213 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1207075010214 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1207075010215 active site 1207075010216 TDP-binding site; other site 1207075010217 acceptor substrate-binding pocket; other site 1207075010218 homodimer interface [polypeptide binding]; other site 1207075010219 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075010220 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075010221 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1207075010222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075010223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075010224 metal binding site [ion binding]; metal-binding site 1207075010225 active site 1207075010226 I-site; other site 1207075010227 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075010228 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075010229 acetylornithine deacetylase; Provisional; Region: PRK07522 1207075010230 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1207075010231 metal binding site [ion binding]; metal-binding site 1207075010232 putative dimer interface [polypeptide binding]; other site 1207075010233 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1207075010234 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1207075010235 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1207075010236 homotrimer interaction site [polypeptide binding]; other site 1207075010237 putative active site [active] 1207075010238 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1207075010239 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1207075010240 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1207075010241 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1207075010242 dimer interface [polypeptide binding]; other site 1207075010243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075010244 catalytic residue [active] 1207075010245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1207075010246 FOG: CBS domain [General function prediction only]; Region: COG0517 1207075010247 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1207075010248 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1207075010249 homodimer interface [polypeptide binding]; other site 1207075010250 substrate-cofactor binding pocket; other site 1207075010251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075010252 catalytic residue [active] 1207075010253 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1207075010254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075010255 substrate binding pocket [chemical binding]; other site 1207075010256 membrane-bound complex binding site; other site 1207075010257 hinge residues; other site 1207075010258 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1207075010259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075010260 Walker A/P-loop; other site 1207075010261 ATP binding site [chemical binding]; other site 1207075010262 Q-loop/lid; other site 1207075010263 ABC transporter signature motif; other site 1207075010264 Walker B; other site 1207075010265 D-loop; other site 1207075010266 H-loop/switch region; other site 1207075010267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010268 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1207075010269 dimer interface [polypeptide binding]; other site 1207075010270 conserved gate region; other site 1207075010271 putative PBP binding loops; other site 1207075010272 ABC-ATPase subunit interface; other site 1207075010273 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1207075010274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010275 dimer interface [polypeptide binding]; other site 1207075010276 conserved gate region; other site 1207075010277 putative PBP binding loops; other site 1207075010278 ABC-ATPase subunit interface; other site 1207075010279 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1207075010280 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1207075010281 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1207075010282 putative active site [active] 1207075010283 putative metal-binding site [ion binding]; other site 1207075010284 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1207075010285 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 1207075010286 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1207075010287 EF-hand domain pair; Region: EF_hand_5; pfam13499 1207075010288 Ca2+ binding site [ion binding]; other site 1207075010289 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1207075010290 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1207075010291 active site 1207075010292 Zn binding site [ion binding]; other site 1207075010293 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075010294 EamA-like transporter family; Region: EamA; pfam00892 1207075010295 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075010296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010297 dimer interface [polypeptide binding]; other site 1207075010298 conserved gate region; other site 1207075010299 ABC-ATPase subunit interface; other site 1207075010300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075010301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010302 dimer interface [polypeptide binding]; other site 1207075010303 conserved gate region; other site 1207075010304 putative PBP binding loops; other site 1207075010305 ABC-ATPase subunit interface; other site 1207075010306 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075010307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075010308 substrate binding pocket [chemical binding]; other site 1207075010309 membrane-bound complex binding site; other site 1207075010310 hinge residues; other site 1207075010311 aspartate aminotransferase; Provisional; Region: PRK05764 1207075010312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075010313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075010314 homodimer interface [polypeptide binding]; other site 1207075010315 catalytic residue [active] 1207075010316 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1207075010317 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075010318 Walker A/P-loop; other site 1207075010319 ATP binding site [chemical binding]; other site 1207075010320 Q-loop/lid; other site 1207075010321 ABC transporter signature motif; other site 1207075010322 Walker B; other site 1207075010323 D-loop; other site 1207075010324 H-loop/switch region; other site 1207075010325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075010326 putative substrate translocation pore; other site 1207075010327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075010328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010329 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1207075010330 putative substrate binding pocket [chemical binding]; other site 1207075010331 putative dimerization interface [polypeptide binding]; other site 1207075010332 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1207075010333 Cupin domain; Region: Cupin_2; pfam07883 1207075010334 Predicted transcriptional regulators [Transcription]; Region: COG1733 1207075010335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075010336 dimerization interface [polypeptide binding]; other site 1207075010337 putative DNA binding site [nucleotide binding]; other site 1207075010338 putative Zn2+ binding site [ion binding]; other site 1207075010339 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075010340 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1207075010341 catalytic triad [active] 1207075010342 conserved cis-peptide bond; other site 1207075010343 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075010344 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1207075010345 dimer interface [polypeptide binding]; other site 1207075010346 NADP binding site [chemical binding]; other site 1207075010347 catalytic residues [active] 1207075010348 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1207075010349 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1207075010350 dimer interface [polypeptide binding]; other site 1207075010351 active site 1207075010352 heme binding site [chemical binding]; other site 1207075010353 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1207075010354 Uncharacterized small protein [Function unknown]; Region: COG2879 1207075010355 carbon starvation protein A; Provisional; Region: PRK15015 1207075010356 Carbon starvation protein CstA; Region: CstA; pfam02554 1207075010357 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1207075010358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1207075010359 Cache domain; Region: Cache_2; pfam08269 1207075010360 Histidine kinase; Region: HisKA_3; pfam07730 1207075010361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075010362 ATP binding site [chemical binding]; other site 1207075010363 Mg2+ binding site [ion binding]; other site 1207075010364 G-X-G motif; other site 1207075010365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075010366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075010367 active site 1207075010368 phosphorylation site [posttranslational modification] 1207075010369 intermolecular recognition site; other site 1207075010370 dimerization interface [polypeptide binding]; other site 1207075010371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075010372 DNA binding residues [nucleotide binding] 1207075010373 dimerization interface [polypeptide binding]; other site 1207075010374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075010375 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075010376 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075010377 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1207075010378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075010379 non-specific DNA binding site [nucleotide binding]; other site 1207075010380 salt bridge; other site 1207075010381 sequence-specific DNA binding site [nucleotide binding]; other site 1207075010382 Cupin domain; Region: Cupin_2; pfam07883 1207075010383 Amino acid synthesis; Region: AA_synth; pfam06684 1207075010384 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1207075010385 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075010386 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1207075010387 NAD(P) binding site [chemical binding]; other site 1207075010388 catalytic residues [active] 1207075010389 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1207075010390 succinic semialdehyde dehydrogenase; Region: PLN02278 1207075010391 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1207075010392 tetramerization interface [polypeptide binding]; other site 1207075010393 NAD(P) binding site [chemical binding]; other site 1207075010394 catalytic residues [active] 1207075010395 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1207075010396 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075010397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075010398 DNA-binding site [nucleotide binding]; DNA binding site 1207075010399 FCD domain; Region: FCD; pfam07729 1207075010400 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1207075010401 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1207075010402 nudix motif; other site 1207075010403 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1207075010404 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1207075010405 C-terminal domain interface [polypeptide binding]; other site 1207075010406 GSH binding site (G-site) [chemical binding]; other site 1207075010407 dimer interface [polypeptide binding]; other site 1207075010408 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1207075010409 dimer interface [polypeptide binding]; other site 1207075010410 N-terminal domain interface [polypeptide binding]; other site 1207075010411 Predicted esterase [General function prediction only]; Region: COG0400 1207075010412 putative hydrolase; Provisional; Region: PRK11460 1207075010413 Predicted deacylase [General function prediction only]; Region: COG3608 1207075010414 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1207075010415 active site 1207075010416 Zn binding site [ion binding]; other site 1207075010417 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075010418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075010419 substrate binding pocket [chemical binding]; other site 1207075010420 membrane-bound complex binding site; other site 1207075010421 hinge residues; other site 1207075010422 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1207075010423 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1207075010424 catalytic triad [active] 1207075010425 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1207075010426 active site residue [active] 1207075010427 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1207075010428 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075010429 conserved cys residue [active] 1207075010430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010431 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1207075010432 active site 1207075010433 SAM binding site [chemical binding]; other site 1207075010434 homodimer interface [polypeptide binding]; other site 1207075010435 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1207075010436 catalytic core [active] 1207075010437 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1207075010438 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1207075010439 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1207075010440 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1207075010441 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1207075010442 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1207075010443 tetramer interface [polypeptide binding]; other site 1207075010444 active site 1207075010445 Mg2+/Mn2+ binding site [ion binding]; other site 1207075010446 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1207075010447 MASE2 domain; Region: MASE2; pfam05230 1207075010448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075010449 metal binding site [ion binding]; metal-binding site 1207075010450 active site 1207075010451 I-site; other site 1207075010452 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1207075010453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1207075010454 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075010455 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1207075010456 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1207075010457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1207075010458 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1207075010459 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1207075010460 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1207075010461 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1207075010462 Walker A/P-loop; other site 1207075010463 ATP binding site [chemical binding]; other site 1207075010464 Q-loop/lid; other site 1207075010465 ABC transporter signature motif; other site 1207075010466 Walker B; other site 1207075010467 D-loop; other site 1207075010468 H-loop/switch region; other site 1207075010469 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1207075010470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1207075010471 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1207075010472 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1207075010473 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 1207075010474 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1207075010475 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1207075010476 dimerization interface [polypeptide binding]; other site 1207075010477 active site 1207075010478 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075010479 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1207075010480 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1207075010481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010482 dimer interface [polypeptide binding]; other site 1207075010483 conserved gate region; other site 1207075010484 putative PBP binding loops; other site 1207075010485 ABC-ATPase subunit interface; other site 1207075010486 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075010487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010488 dimer interface [polypeptide binding]; other site 1207075010489 conserved gate region; other site 1207075010490 putative PBP binding loops; other site 1207075010491 ABC-ATPase subunit interface; other site 1207075010492 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075010493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075010494 Walker A/P-loop; other site 1207075010495 ATP binding site [chemical binding]; other site 1207075010496 Q-loop/lid; other site 1207075010497 ABC transporter signature motif; other site 1207075010498 Walker B; other site 1207075010499 D-loop; other site 1207075010500 H-loop/switch region; other site 1207075010501 TOBE domain; Region: TOBE_2; pfam08402 1207075010502 amidase; Validated; Region: PRK06565 1207075010503 Amidase; Region: Amidase; cl11426 1207075010504 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1207075010505 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1207075010506 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075010507 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075010508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010509 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075010510 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075010511 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1207075010512 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075010513 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1207075010514 N-terminal domain interface [polypeptide binding]; other site 1207075010515 dimer interface [polypeptide binding]; other site 1207075010516 substrate binding pocket (H-site) [chemical binding]; other site 1207075010517 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1207075010518 N-terminal domain interface [polypeptide binding]; other site 1207075010519 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075010520 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075010521 Na binding site [ion binding]; other site 1207075010522 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1207075010523 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1207075010524 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1207075010525 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075010526 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1207075010527 catalytic triad [active] 1207075010528 conserved cis-peptide bond; other site 1207075010529 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1207075010530 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075010531 Na binding site [ion binding]; other site 1207075010532 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075010533 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075010534 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1207075010535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075010536 non-specific DNA binding site [nucleotide binding]; other site 1207075010537 salt bridge; other site 1207075010538 sequence-specific DNA binding site [nucleotide binding]; other site 1207075010539 Cupin domain; Region: Cupin_2; pfam07883 1207075010540 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075010541 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075010542 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1207075010543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075010544 Predicted transcriptional regulator [Transcription]; Region: COG1959 1207075010545 Transcriptional regulator; Region: Rrf2; pfam02082 1207075010546 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1207075010547 Sporulation related domain; Region: SPOR; cl10051 1207075010548 Serine hydrolase; Region: Ser_hydrolase; cl17834 1207075010549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075010550 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1207075010551 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1207075010552 putative NAD(P) binding site [chemical binding]; other site 1207075010553 active site 1207075010554 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1207075010555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075010556 catalytic loop [active] 1207075010557 iron binding site [ion binding]; other site 1207075010558 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1207075010559 FAD binding pocket [chemical binding]; other site 1207075010560 FAD binding motif [chemical binding]; other site 1207075010561 phosphate binding motif [ion binding]; other site 1207075010562 beta-alpha-beta structure motif; other site 1207075010563 NAD binding pocket [chemical binding]; other site 1207075010564 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1207075010565 inter-subunit interface; other site 1207075010566 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1207075010567 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1207075010568 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1207075010569 putative alpha subunit interface [polypeptide binding]; other site 1207075010570 putative active site [active] 1207075010571 putative substrate binding site [chemical binding]; other site 1207075010572 Fe binding site [ion binding]; other site 1207075010573 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075010574 Helix-turn-helix domain; Region: HTH_18; pfam12833 1207075010575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010576 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1207075010577 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1207075010578 dimer interface [polypeptide binding]; other site 1207075010579 active site 1207075010580 Muconolactone delta-isomerase; Region: MIase; pfam02426 1207075010581 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1207075010582 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1207075010583 octamer interface [polypeptide binding]; other site 1207075010584 active site 1207075010585 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1207075010586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075010588 dimerization interface [polypeptide binding]; other site 1207075010589 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1207075010590 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1207075010591 NodB motif; other site 1207075010592 active site 1207075010593 catalytic site [active] 1207075010594 metal binding site [ion binding]; metal-binding site 1207075010595 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1207075010596 Predicted membrane protein [Function unknown]; Region: COG4392 1207075010597 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1207075010598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075010599 PAS fold; Region: PAS_3; pfam08447 1207075010600 putative active site [active] 1207075010601 heme pocket [chemical binding]; other site 1207075010602 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075010603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075010604 metal binding site [ion binding]; metal-binding site 1207075010605 active site 1207075010606 I-site; other site 1207075010607 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1207075010608 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1207075010609 dimer interface [polypeptide binding]; other site 1207075010610 active site 1207075010611 catalytic residue [active] 1207075010612 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1207075010613 Cache domain; Region: Cache_1; pfam02743 1207075010614 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075010615 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075010616 metal binding site [ion binding]; metal-binding site 1207075010617 active site 1207075010618 I-site; other site 1207075010619 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1207075010620 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1207075010621 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1207075010622 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1207075010623 nudix motif; other site 1207075010624 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1207075010625 Sel1-like repeats; Region: SEL1; smart00671 1207075010626 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1207075010627 Sel1-like repeats; Region: SEL1; smart00671 1207075010628 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1207075010629 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1207075010630 putative active site [active] 1207075010631 putative active site [active] 1207075010632 catalytic site [active] 1207075010633 catalytic site [active] 1207075010634 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1207075010635 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1207075010636 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1207075010637 putative active site [active] 1207075010638 catalytic site [active] 1207075010639 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1207075010640 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1207075010641 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1207075010642 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1207075010643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1207075010644 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1207075010645 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1207075010646 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1207075010647 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1207075010648 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1207075010649 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1207075010650 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075010651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1207075010652 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1207075010653 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1207075010654 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1207075010655 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1207075010656 Walker A motif; other site 1207075010657 ATP binding site [chemical binding]; other site 1207075010658 Walker B motif; other site 1207075010659 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075010660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075010661 active site 1207075010662 phosphorylation site [posttranslational modification] 1207075010663 intermolecular recognition site; other site 1207075010664 dimerization interface [polypeptide binding]; other site 1207075010665 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075010666 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1207075010667 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1207075010668 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1207075010669 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1207075010670 Cu(I) binding site [ion binding]; other site 1207075010671 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1207075010672 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1207075010673 Cu(I) binding site [ion binding]; other site 1207075010674 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075010675 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075010676 catalytic residue [active] 1207075010677 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1207075010678 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1207075010679 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1207075010680 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1207075010681 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1207075010682 LysR family transcriptional regulator; Provisional; Region: PRK14997 1207075010683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010684 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075010685 putative effector binding pocket; other site 1207075010686 dimerization interface [polypeptide binding]; other site 1207075010687 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1207075010688 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075010689 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1207075010690 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075010691 ligand binding site [chemical binding]; other site 1207075010692 flexible hinge region; other site 1207075010693 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075010694 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1207075010695 catalytic triad [active] 1207075010696 dimer interface [polypeptide binding]; other site 1207075010697 conserved cis-peptide bond; other site 1207075010698 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1207075010699 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1207075010700 active site 1207075010701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1207075010702 Predicted membrane protein [Function unknown]; Region: COG2259 1207075010703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075010704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010705 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1207075010706 putative substrate binding pocket [chemical binding]; other site 1207075010707 putative dimerization interface [polypeptide binding]; other site 1207075010708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010709 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075010710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010711 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075010712 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075010713 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075010714 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1207075010715 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075010716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075010717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075010718 DNA binding site [nucleotide binding] 1207075010719 Predicted ATPase [General function prediction only]; Region: COG3903 1207075010720 Predicted ATPase [General function prediction only]; Region: COG3903 1207075010721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075010722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075010723 DNA binding site [nucleotide binding] 1207075010724 AAA ATPase domain; Region: AAA_16; pfam13191 1207075010725 Predicted ATPase [General function prediction only]; Region: COG3903 1207075010726 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075010727 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075010728 conserved cys residue [active] 1207075010729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010731 Pirin-related protein [General function prediction only]; Region: COG1741 1207075010732 Pirin; Region: Pirin; pfam02678 1207075010733 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075010734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075010735 SurA N-terminal domain; Region: SurA_N; pfam09312 1207075010736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010737 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1207075010738 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1207075010739 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1207075010740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075010741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075010742 YcaO domain protein; Region: TIGR03549 1207075010743 OsmC-like protein; Region: OsmC; pfam02566 1207075010744 YcaO-like family; Region: YcaO; pfam02624 1207075010745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075010746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010747 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1207075010748 putative dimerization interface [polypeptide binding]; other site 1207075010749 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1207075010750 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1207075010751 NAD(P) binding site [chemical binding]; other site 1207075010752 catalytic residues [active] 1207075010753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075010754 putative substrate translocation pore; other site 1207075010755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075010756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010757 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1207075010758 putative dimerization interface [polypeptide binding]; other site 1207075010759 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1207075010760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075010761 putative substrate translocation pore; other site 1207075010762 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1207075010763 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1207075010764 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075010765 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1207075010766 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1207075010767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010768 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1207075010769 dimerization interface [polypeptide binding]; other site 1207075010770 substrate binding pocket [chemical binding]; other site 1207075010771 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1207075010772 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1207075010773 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1207075010774 aspartate aminotransferase; Provisional; Region: PRK05764 1207075010775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075010776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075010777 homodimer interface [polypeptide binding]; other site 1207075010778 catalytic residue [active] 1207075010779 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075010780 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1207075010781 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1207075010782 PYR/PP interface [polypeptide binding]; other site 1207075010783 dimer interface [polypeptide binding]; other site 1207075010784 TPP binding site [chemical binding]; other site 1207075010785 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 1207075010786 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 1207075010787 TPP-binding site; other site 1207075010788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075010789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075010790 active site 1207075010791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075010792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075010793 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1207075010794 Ligand binding site [chemical binding]; other site 1207075010795 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1207075010796 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1207075010797 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1207075010798 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1207075010799 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1207075010800 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1207075010801 active site 2 [active] 1207075010802 active site 1 [active] 1207075010803 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1207075010804 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1207075010805 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1207075010806 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1207075010807 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1207075010808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075010809 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 1207075010810 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1207075010811 amidase; Provisional; Region: PRK07235 1207075010812 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1207075010813 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1207075010814 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 1207075010815 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1207075010816 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1207075010817 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1207075010818 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1207075010819 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1207075010820 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1207075010821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1207075010822 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1207075010823 Cytochrome c; Region: Cytochrom_C; cl11414 1207075010824 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075010825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075010826 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1207075010827 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1207075010828 DNA binding residues [nucleotide binding] 1207075010829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075010830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075010832 dimerization interface [polypeptide binding]; other site 1207075010833 SnoaL-like domain; Region: SnoaL_2; pfam12680 1207075010834 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1207075010835 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1207075010836 putative NADP binding site [chemical binding]; other site 1207075010837 putative substrate binding site [chemical binding]; other site 1207075010838 active site 1207075010839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075010840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075010841 putative substrate translocation pore; other site 1207075010842 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1207075010843 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1207075010844 putative substrate binding site [chemical binding]; other site 1207075010845 putative ATP binding site [chemical binding]; other site 1207075010846 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1207075010847 trimer interface; other site 1207075010848 sugar binding site [chemical binding]; other site 1207075010849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1207075010850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1207075010851 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075010852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010853 dimer interface [polypeptide binding]; other site 1207075010854 conserved gate region; other site 1207075010855 putative PBP binding loops; other site 1207075010856 ABC-ATPase subunit interface; other site 1207075010857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1207075010858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075010859 dimer interface [polypeptide binding]; other site 1207075010860 conserved gate region; other site 1207075010861 ABC-ATPase subunit interface; other site 1207075010862 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1207075010863 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1207075010864 Walker A/P-loop; other site 1207075010865 ATP binding site [chemical binding]; other site 1207075010866 Q-loop/lid; other site 1207075010867 ABC transporter signature motif; other site 1207075010868 Walker B; other site 1207075010869 D-loop; other site 1207075010870 H-loop/switch region; other site 1207075010871 TOBE domain; Region: TOBE_2; pfam08402 1207075010872 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1207075010873 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1207075010874 substrate binding [chemical binding]; other site 1207075010875 active site 1207075010876 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1207075010877 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1207075010878 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1207075010879 DNA binding site [nucleotide binding] 1207075010880 domain linker motif; other site 1207075010881 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1207075010882 putative dimerization interface [polypeptide binding]; other site 1207075010883 putative ligand binding site [chemical binding]; other site 1207075010884 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075010885 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1207075010886 Citrate transporter; Region: CitMHS; pfam03600 1207075010887 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1207075010888 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075010889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1207075010890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075010891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010892 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1207075010893 putative dimerization interface [polypeptide binding]; other site 1207075010894 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1207075010895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075010896 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1207075010897 putative dimerization interface [polypeptide binding]; other site 1207075010898 tricarballylate dehydrogenase; Validated; Region: PRK08274 1207075010899 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1207075010900 citrate-proton symporter; Provisional; Region: PRK15075 1207075010901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075010902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075010903 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1207075010904 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1207075010905 DNA binding residues [nucleotide binding] 1207075010906 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1207075010907 IHF dimer interface [polypeptide binding]; other site 1207075010908 IHF - DNA interface [nucleotide binding]; other site 1207075010909 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1207075010910 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1207075010911 putative tRNA-binding site [nucleotide binding]; other site 1207075010912 B3/4 domain; Region: B3_4; pfam03483 1207075010913 tRNA synthetase B5 domain; Region: B5; smart00874 1207075010914 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1207075010915 dimer interface [polypeptide binding]; other site 1207075010916 motif 1; other site 1207075010917 motif 3; other site 1207075010918 motif 2; other site 1207075010919 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1207075010920 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1207075010921 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1207075010922 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1207075010923 dimer interface [polypeptide binding]; other site 1207075010924 motif 1; other site 1207075010925 active site 1207075010926 motif 2; other site 1207075010927 motif 3; other site 1207075010928 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1207075010929 23S rRNA binding site [nucleotide binding]; other site 1207075010930 L21 binding site [polypeptide binding]; other site 1207075010931 L13 binding site [polypeptide binding]; other site 1207075010932 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1207075010933 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1207075010934 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1207075010935 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1207075010936 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1207075010937 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1207075010938 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1207075010939 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1207075010940 active site 1207075010941 dimer interface [polypeptide binding]; other site 1207075010942 motif 1; other site 1207075010943 motif 2; other site 1207075010944 motif 3; other site 1207075010945 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1207075010946 anticodon binding site; other site 1207075010947 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1207075010948 DNA-binding site [nucleotide binding]; DNA binding site 1207075010949 RNA-binding motif; other site 1207075010950 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1207075010951 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1207075010952 active site 1207075010953 tetramer interface [polypeptide binding]; other site 1207075010954 D-ribose pyranase; Provisional; Region: PRK11797 1207075010955 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1207075010956 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1207075010957 substrate binding site [chemical binding]; other site 1207075010958 dimer interface [polypeptide binding]; other site 1207075010959 ATP binding site [chemical binding]; other site 1207075010960 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1207075010961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1207075010962 DNA binding site [nucleotide binding] 1207075010963 domain linker motif; other site 1207075010964 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1207075010965 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1207075010966 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1207075010967 TM-ABC transporter signature motif; other site 1207075010968 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1207075010969 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1207075010970 Walker A/P-loop; other site 1207075010971 ATP binding site [chemical binding]; other site 1207075010972 Q-loop/lid; other site 1207075010973 ABC transporter signature motif; other site 1207075010974 Walker B; other site 1207075010975 D-loop; other site 1207075010976 H-loop/switch region; other site 1207075010977 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1207075010978 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1207075010979 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1207075010980 ligand binding site [chemical binding]; other site 1207075010981 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1207075010982 homodimer interface [polypeptide binding]; other site 1207075010983 active site 1207075010984 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1207075010985 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1207075010986 carbon storage regulator; Provisional; Region: PRK01712 1207075010987 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 1207075010988 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1207075010989 active site clefts [active] 1207075010990 zinc binding site [ion binding]; other site 1207075010991 dimer interface [polypeptide binding]; other site 1207075010992 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1207075010993 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1207075010994 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1207075010995 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1207075010996 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075010997 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1207075010998 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075010999 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075011000 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1207075011001 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1207075011002 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1207075011003 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1207075011004 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1207075011005 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075011006 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1207075011007 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1207075011008 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1207075011009 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075011010 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1207075011011 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075011012 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1207075011013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075011014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075011015 dimerization interface [polypeptide binding]; other site 1207075011016 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1207075011017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075011018 putative substrate translocation pore; other site 1207075011019 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1207075011020 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1207075011021 putative active site pocket [active] 1207075011022 putative metal binding site [ion binding]; other site 1207075011023 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1207075011024 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1207075011025 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075011026 NAD binding site [chemical binding]; other site 1207075011027 catalytic residues [active] 1207075011028 substrate binding site [chemical binding]; other site 1207075011029 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1207075011030 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1207075011031 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1207075011032 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1207075011033 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1207075011034 Walker A/P-loop; other site 1207075011035 ATP binding site [chemical binding]; other site 1207075011036 Q-loop/lid; other site 1207075011037 ABC transporter signature motif; other site 1207075011038 Walker B; other site 1207075011039 D-loop; other site 1207075011040 H-loop/switch region; other site 1207075011041 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1207075011042 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1207075011043 ABC-ATPase subunit interface; other site 1207075011044 dimer interface [polypeptide binding]; other site 1207075011045 putative PBP binding regions; other site 1207075011046 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1207075011047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1207075011048 ABC-ATPase subunit interface; other site 1207075011049 dimer interface [polypeptide binding]; other site 1207075011050 putative PBP binding regions; other site 1207075011051 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1207075011052 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1207075011053 siderophore binding site; other site 1207075011054 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075011055 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1207075011056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075011057 N-terminal plug; other site 1207075011058 ligand-binding site [chemical binding]; other site 1207075011059 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1207075011060 FecR protein; Region: FecR; pfam04773 1207075011061 RNA polymerase sigma factor; Provisional; Region: PRK12528 1207075011062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075011063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075011064 DNA binding residues [nucleotide binding] 1207075011065 oxidoreductase; Validated; Region: PRK05717 1207075011066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075011067 NAD(P) binding site [chemical binding]; other site 1207075011068 active site 1207075011069 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1207075011070 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1207075011071 homodimer interface [polypeptide binding]; other site 1207075011072 substrate-cofactor binding pocket; other site 1207075011073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075011074 catalytic residue [active] 1207075011075 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1207075011076 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1207075011077 active site 1207075011078 tetramer interface [polypeptide binding]; other site 1207075011079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075011080 active site 1207075011081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1207075011082 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1207075011083 Colicin V production protein; Region: Colicin_V; cl00567 1207075011084 Sporulation related domain; Region: SPOR; pfam05036 1207075011085 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1207075011086 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1207075011087 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1207075011088 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1207075011089 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1207075011090 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1207075011091 active site 1207075011092 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1207075011093 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1207075011094 dimerization interface 3.5A [polypeptide binding]; other site 1207075011095 active site 1207075011096 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1207075011097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1207075011098 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1207075011099 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1207075011100 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1207075011101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075011102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075011103 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075011104 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1207075011105 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1207075011106 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1207075011107 tartrate dehydrogenase; Region: TTC; TIGR02089 1207075011108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075011109 S-adenosylmethionine binding site [chemical binding]; other site 1207075011110 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1207075011111 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1207075011112 substrate binding site [chemical binding]; other site 1207075011113 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1207075011114 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1207075011115 substrate binding site [chemical binding]; other site 1207075011116 ligand binding site [chemical binding]; other site 1207075011117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075011118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075011119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075011120 dimerization interface [polypeptide binding]; other site 1207075011121 PAS fold; Region: PAS_3; pfam08447 1207075011122 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075011123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011124 putative active site [active] 1207075011125 heme pocket [chemical binding]; other site 1207075011126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011127 heme pocket [chemical binding]; other site 1207075011128 putative active site [active] 1207075011129 PAS domain S-box; Region: sensory_box; TIGR00229 1207075011130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011131 putative active site [active] 1207075011132 heme pocket [chemical binding]; other site 1207075011133 PAS domain S-box; Region: sensory_box; TIGR00229 1207075011134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011135 putative active site [active] 1207075011136 heme pocket [chemical binding]; other site 1207075011137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075011138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075011139 metal binding site [ion binding]; metal-binding site 1207075011140 active site 1207075011141 I-site; other site 1207075011142 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075011143 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1207075011144 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1207075011145 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075011146 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1207075011147 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1207075011148 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1207075011149 active site 1207075011150 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1207075011151 active site 1207075011152 catalytic residues [active] 1207075011153 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075011154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1207075011155 putative acyl-acceptor binding pocket; other site 1207075011156 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1207075011157 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1207075011158 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1207075011159 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1207075011160 putative dimer interface [polypeptide binding]; other site 1207075011161 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1207075011162 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1207075011163 FMN binding site [chemical binding]; other site 1207075011164 active site 1207075011165 catalytic residues [active] 1207075011166 substrate binding site [chemical binding]; other site 1207075011167 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1207075011168 active site 1207075011169 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075011170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075011171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075011172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075011173 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1207075011174 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1207075011175 active site 1207075011176 HIGH motif; other site 1207075011177 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1207075011178 active site 1207075011179 KMSKS motif; other site 1207075011180 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1207075011181 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075011182 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075011183 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1207075011184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075011185 putative substrate translocation pore; other site 1207075011186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075011187 excinuclease ABC subunit B; Provisional; Region: PRK05298 1207075011188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075011189 ATP binding site [chemical binding]; other site 1207075011190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075011191 nucleotide binding region [chemical binding]; other site 1207075011192 ATP-binding site [chemical binding]; other site 1207075011193 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1207075011194 UvrB/uvrC motif; Region: UVR; pfam02151 1207075011195 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1207075011196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075011197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075011198 homodimer interface [polypeptide binding]; other site 1207075011199 catalytic residue [active] 1207075011200 xanthine permease; Region: pbuX; TIGR03173 1207075011201 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075011202 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1207075011203 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1207075011204 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1207075011205 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1207075011206 putative catalytic site [active] 1207075011207 putative phosphate binding site [ion binding]; other site 1207075011208 active site 1207075011209 metal binding site A [ion binding]; metal-binding site 1207075011210 DNA binding site [nucleotide binding] 1207075011211 putative AP binding site [nucleotide binding]; other site 1207075011212 putative metal binding site B [ion binding]; other site 1207075011213 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1207075011214 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1207075011215 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1207075011216 Cache domain; Region: Cache_1; pfam02743 1207075011217 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075011218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075011219 metal binding site [ion binding]; metal-binding site 1207075011220 active site 1207075011221 I-site; other site 1207075011222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1207075011223 DNA polymerase (viral) N-terminal domain; Region: DNA_pol_viral_N; pfam00242 1207075011224 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1207075011225 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1207075011226 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1207075011227 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1207075011228 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1207075011229 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1207075011230 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1207075011231 CopC domain; Region: CopC; pfam04234 1207075011232 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1207075011233 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1207075011234 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1207075011235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075011236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075011237 substrate binding pocket [chemical binding]; other site 1207075011238 membrane-bound complex binding site; other site 1207075011239 hinge residues; other site 1207075011240 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1207075011241 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1207075011242 FMN binding site [chemical binding]; other site 1207075011243 active site 1207075011244 catalytic residues [active] 1207075011245 substrate binding site [chemical binding]; other site 1207075011246 transaldolase-like protein; Provisional; Region: PTZ00411 1207075011247 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1207075011248 active site 1207075011249 dimer interface [polypeptide binding]; other site 1207075011250 catalytic residue [active] 1207075011251 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1207075011252 anti sigma factor interaction site; other site 1207075011253 regulatory phosphorylation site [posttranslational modification]; other site 1207075011254 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075011255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075011256 active site 1207075011257 phosphorylation site [posttranslational modification] 1207075011258 intermolecular recognition site; other site 1207075011259 dimerization interface [polypeptide binding]; other site 1207075011260 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1207075011261 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1207075011262 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1207075011263 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1207075011264 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1207075011265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1207075011266 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1207075011267 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1207075011268 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1207075011269 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1207075011270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075011271 active site 1207075011272 phosphorylation site [posttranslational modification] 1207075011273 intermolecular recognition site; other site 1207075011274 dimerization interface [polypeptide binding]; other site 1207075011275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075011276 DNA binding site [nucleotide binding] 1207075011277 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1207075011278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075011279 dimerization interface [polypeptide binding]; other site 1207075011280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075011281 dimer interface [polypeptide binding]; other site 1207075011282 phosphorylation site [posttranslational modification] 1207075011283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075011284 ATP binding site [chemical binding]; other site 1207075011285 Mg2+ binding site [ion binding]; other site 1207075011286 G-X-G motif; other site 1207075011287 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1207075011288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1207075011289 FtsX-like permease family; Region: FtsX; pfam02687 1207075011290 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1207075011291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1207075011292 Walker A/P-loop; other site 1207075011293 ATP binding site [chemical binding]; other site 1207075011294 Q-loop/lid; other site 1207075011295 ABC transporter signature motif; other site 1207075011296 Walker B; other site 1207075011297 D-loop; other site 1207075011298 H-loop/switch region; other site 1207075011299 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1207075011300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1207075011301 FtsX-like permease family; Region: FtsX; pfam02687 1207075011302 PilZ domain; Region: PilZ; pfam07238 1207075011303 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1207075011304 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1207075011305 active site 1207075011306 catalytic site [active] 1207075011307 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1207075011308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075011309 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1207075011310 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1207075011311 ApbE family; Region: ApbE; pfam02424 1207075011312 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1207075011313 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1207075011314 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1207075011315 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1207075011316 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1207075011317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075011318 ATP binding site [chemical binding]; other site 1207075011319 putative Mg++ binding site [ion binding]; other site 1207075011320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075011321 nucleotide binding region [chemical binding]; other site 1207075011322 ATP-binding site [chemical binding]; other site 1207075011323 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1207075011324 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1207075011325 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1207075011326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075011327 ATP binding site [chemical binding]; other site 1207075011328 putative Mg++ binding site [ion binding]; other site 1207075011329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075011330 nucleotide binding region [chemical binding]; other site 1207075011331 ATP-binding site [chemical binding]; other site 1207075011332 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 1207075011333 beta-hexosaminidase; Provisional; Region: PRK05337 1207075011334 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1207075011335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075011336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075011337 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1207075011338 LexA repressor; Validated; Region: PRK00215 1207075011339 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1207075011340 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1207075011341 Catalytic site [active] 1207075011342 Cell division inhibitor SulA; Region: SulA; cl01880 1207075011343 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1207075011344 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1207075011345 active site 1207075011346 interdomain interaction site; other site 1207075011347 putative metal-binding site [ion binding]; other site 1207075011348 nucleotide binding site [chemical binding]; other site 1207075011349 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1207075011350 domain I; other site 1207075011351 DNA binding groove [nucleotide binding] 1207075011352 phosphate binding site [ion binding]; other site 1207075011353 domain II; other site 1207075011354 domain III; other site 1207075011355 nucleotide binding site [chemical binding]; other site 1207075011356 catalytic site [active] 1207075011357 domain IV; other site 1207075011358 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1207075011359 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1207075011360 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1207075011361 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1207075011362 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1207075011363 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1207075011364 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075011365 dimer interface [polypeptide binding]; other site 1207075011366 active site 1207075011367 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1207075011368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075011369 substrate binding site [chemical binding]; other site 1207075011370 oxyanion hole (OAH) forming residues; other site 1207075011371 trimer interface [polypeptide binding]; other site 1207075011372 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1207075011373 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1207075011374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1207075011375 Ligand Binding Site [chemical binding]; other site 1207075011376 ABC transporter ATPase component; Reviewed; Region: PRK11147 1207075011377 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075011378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075011379 ABC transporter; Region: ABC_tran_2; pfam12848 1207075011380 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075011381 lytic murein transglycosylase; Provisional; Region: PRK11619 1207075011382 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075011383 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075011384 catalytic residue [active] 1207075011385 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1207075011386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075011387 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1207075011388 Walker A/P-loop; other site 1207075011389 ATP binding site [chemical binding]; other site 1207075011390 Q-loop/lid; other site 1207075011391 ABC transporter signature motif; other site 1207075011392 Walker B; other site 1207075011393 D-loop; other site 1207075011394 H-loop/switch region; other site 1207075011395 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1207075011396 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1207075011397 ligand binding site [chemical binding]; other site 1207075011398 NAD binding site [chemical binding]; other site 1207075011399 catalytic site [active] 1207075011400 homodimer interface [polypeptide binding]; other site 1207075011401 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1207075011402 multidrug efflux protein; Reviewed; Region: PRK01766 1207075011403 cation binding site [ion binding]; other site 1207075011404 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1207075011405 CPxP motif; other site 1207075011406 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1207075011407 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1207075011408 aconitate hydratase; Validated; Region: PRK09277 1207075011409 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1207075011410 substrate binding site [chemical binding]; other site 1207075011411 ligand binding site [chemical binding]; other site 1207075011412 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1207075011413 substrate binding site [chemical binding]; other site 1207075011414 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1207075011415 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1207075011416 active site 1207075011417 Chain length determinant protein; Region: Wzz; pfam02706 1207075011418 tyrosine kinase; Provisional; Region: PRK11519 1207075011419 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1207075011420 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075011421 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1207075011422 transcriptional activator RfaH; Region: RfaH; TIGR01955 1207075011423 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1207075011424 heterodimer interface [polypeptide binding]; other site 1207075011425 homodimer interface [polypeptide binding]; other site 1207075011426 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1207075011427 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1207075011428 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1207075011429 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1207075011430 active site 1207075011431 nucleotide binding site [chemical binding]; other site 1207075011432 HIGH motif; other site 1207075011433 KMSKS motif; other site 1207075011434 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1207075011435 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1207075011436 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1207075011437 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1207075011438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075011439 active site 1207075011440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075011441 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1207075011442 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1207075011443 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1207075011444 NAD binding site [chemical binding]; other site 1207075011445 substrate binding site [chemical binding]; other site 1207075011446 homodimer interface [polypeptide binding]; other site 1207075011447 active site 1207075011448 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1207075011449 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1207075011450 substrate binding site; other site 1207075011451 tetramer interface; other site 1207075011452 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1207075011453 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1207075011454 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1207075011455 NADP binding site [chemical binding]; other site 1207075011456 active site 1207075011457 putative substrate binding site [chemical binding]; other site 1207075011458 polysaccharide export protein Wza; Provisional; Region: PRK15078 1207075011459 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1207075011460 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1207075011461 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1207075011462 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1207075011463 PAS domain; Region: PAS_9; pfam13426 1207075011464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011465 putative active site [active] 1207075011466 heme pocket [chemical binding]; other site 1207075011467 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075011468 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075011469 dimer interface [polypeptide binding]; other site 1207075011470 putative CheW interface [polypeptide binding]; other site 1207075011471 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1207075011472 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1207075011473 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1207075011474 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1207075011475 Low-spin heme binding site [chemical binding]; other site 1207075011476 Putative water exit pathway; other site 1207075011477 Binuclear center (active site) [active] 1207075011478 Putative proton exit pathway; other site 1207075011479 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1207075011480 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1207075011481 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1207075011482 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1207075011483 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1207075011484 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075011485 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1207075011486 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1207075011487 Low-spin heme binding site [chemical binding]; other site 1207075011488 Putative water exit pathway; other site 1207075011489 Binuclear center (active site) [active] 1207075011490 Putative proton exit pathway; other site 1207075011491 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1207075011492 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1207075011493 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1207075011494 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1207075011495 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075011496 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075011497 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1207075011498 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1207075011499 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1207075011500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1207075011501 FixH; Region: FixH; pfam05751 1207075011502 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1207075011503 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1207075011504 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1207075011505 metal-binding site [ion binding] 1207075011506 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1207075011507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075011508 motif II; other site 1207075011509 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 1207075011510 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1207075011511 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1207075011512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075011513 FeS/SAM binding site; other site 1207075011514 HemN C-terminal domain; Region: HemN_C; pfam06969 1207075011515 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1207075011516 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075011517 ligand binding site [chemical binding]; other site 1207075011518 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1207075011519 putative switch regulator; other site 1207075011520 non-specific DNA interactions [nucleotide binding]; other site 1207075011521 DNA binding site [nucleotide binding] 1207075011522 sequence specific DNA binding site [nucleotide binding]; other site 1207075011523 putative cAMP binding site [chemical binding]; other site 1207075011524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075011525 active site 1207075011526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075011527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075011528 active site 1207075011529 recombination protein RecR; Reviewed; Region: recR; PRK00076 1207075011530 RecR protein; Region: RecR; pfam02132 1207075011531 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1207075011532 putative active site [active] 1207075011533 putative metal-binding site [ion binding]; other site 1207075011534 tetramer interface [polypeptide binding]; other site 1207075011535 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1207075011536 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1207075011537 NAD(P) binding site [chemical binding]; other site 1207075011538 substrate binding site [chemical binding]; other site 1207075011539 dimer interface [polypeptide binding]; other site 1207075011540 hypothetical protein; Validated; Region: PRK00153 1207075011541 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1207075011542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075011543 Walker A motif; other site 1207075011544 ATP binding site [chemical binding]; other site 1207075011545 Walker B motif; other site 1207075011546 arginine finger; other site 1207075011547 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1207075011548 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075011549 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 1207075011550 Int/Topo IB signature motif; other site 1207075011551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1207075011552 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1207075011553 ATP binding site [chemical binding]; other site 1207075011554 putative Mg++ binding site [ion binding]; other site 1207075011555 Helix-turn-helix domain; Region: HTH_28; pfam13518 1207075011556 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1207075011557 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1207075011558 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1207075011559 catalytic residues [active] 1207075011560 catalytic nucleophile [active] 1207075011561 Presynaptic Site I dimer interface [polypeptide binding]; other site 1207075011562 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1207075011563 Synaptic Flat tetramer interface [polypeptide binding]; other site 1207075011564 Synaptic Site I dimer interface [polypeptide binding]; other site 1207075011565 DNA binding site [nucleotide binding] 1207075011566 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1207075011567 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1207075011568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1207075011569 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1207075011570 Ligase N family; Region: LIGANc; smart00532 1207075011571 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1207075011572 nucleotide binding pocket [chemical binding]; other site 1207075011573 K-X-D-G motif; other site 1207075011574 catalytic site [active] 1207075011575 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1207075011576 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1207075011577 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1207075011578 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1207075011579 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1207075011580 Dimer interface [polypeptide binding]; other site 1207075011581 BRCT sequence motif; other site 1207075011582 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1207075011583 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1207075011584 FtsZ protein binding site [polypeptide binding]; other site 1207075011585 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1207075011586 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1207075011587 Walker A/P-loop; other site 1207075011588 ATP binding site [chemical binding]; other site 1207075011589 Q-loop/lid; other site 1207075011590 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1207075011591 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1207075011592 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1207075011593 ABC transporter signature motif; other site 1207075011594 Walker B; other site 1207075011595 D-loop; other site 1207075011596 H-loop/switch region; other site 1207075011597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075011598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075011599 DNA-binding site [nucleotide binding]; DNA binding site 1207075011600 FCD domain; Region: FCD; cl11656 1207075011601 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1207075011602 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075011603 catalytic loop [active] 1207075011604 iron binding site [ion binding]; other site 1207075011605 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1207075011606 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1207075011607 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1207075011608 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1207075011609 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075011610 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1207075011611 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1207075011612 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1207075011613 guanine deaminase; Provisional; Region: PRK09228 1207075011614 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1207075011615 active site 1207075011616 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075011617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075011618 DNA-binding site [nucleotide binding]; DNA binding site 1207075011619 FCD domain; Region: FCD; pfam07729 1207075011620 benzoate transporter; Region: benE; TIGR00843 1207075011621 Benzoate membrane transport protein; Region: BenE; pfam03594 1207075011622 Protein with unknown function (DUF469); Region: DUF469; cl01237 1207075011623 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1207075011624 CHASE domain; Region: CHASE; pfam03924 1207075011625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011626 PAS domain; Region: PAS_9; pfam13426 1207075011627 putative active site [active] 1207075011628 heme pocket [chemical binding]; other site 1207075011629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075011630 PAS fold; Region: PAS_3; pfam08447 1207075011631 putative active site [active] 1207075011632 heme pocket [chemical binding]; other site 1207075011633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075011634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075011635 metal binding site [ion binding]; metal-binding site 1207075011636 active site 1207075011637 I-site; other site 1207075011638 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1207075011639 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1207075011640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075011641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075011642 S-adenosylmethionine binding site [chemical binding]; other site 1207075011643 Ribosome modulation factor; Region: RMF; pfam04957 1207075011644 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1207075011645 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1207075011646 quinone interaction residues [chemical binding]; other site 1207075011647 active site 1207075011648 catalytic residues [active] 1207075011649 FMN binding site [chemical binding]; other site 1207075011650 substrate binding site [chemical binding]; other site 1207075011651 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 1207075011652 invasion protein OrgB; Provisional; Region: PRK15322 1207075011653 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1207075011654 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1207075011655 Type III secretion needle MxiH like; Region: MxiH; cl09641 1207075011656 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 1207075011657 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1207075011658 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1207075011659 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075011660 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075011661 catalytic residue [active] 1207075011662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075011663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075011664 DNA binding site [nucleotide binding] 1207075011665 Predicted integral membrane protein [Function unknown]; Region: COG5616 1207075011666 TPR repeat; Region: TPR_11; pfam13414 1207075011667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075011668 TPR motif; other site 1207075011669 binding surface 1207075011670 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1207075011671 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 1207075011672 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 1207075011673 chaperone protein SicA; Provisional; Region: PRK15331 1207075011674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075011675 binding surface 1207075011676 TPR motif; other site 1207075011677 type III secretion system protein SpaS; Validated; Region: PRK08156 1207075011678 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1207075011679 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1207075011680 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1207075011681 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1207075011682 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1207075011683 ATP synthase SpaL; Validated; Region: PRK08149 1207075011684 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1207075011685 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1207075011686 Walker A motif; other site 1207075011687 ATP binding site [chemical binding]; other site 1207075011688 Walker B motif; other site 1207075011689 Invasion protein B family; Region: Invas_SpaK; cl04129 1207075011690 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1207075011691 type III secretion system protein InvA; Provisional; Region: PRK15337 1207075011692 HrpJ-like domain; Region: HrpJ; cl15454 1207075011693 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1207075011694 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1207075011695 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1207075011696 transcriptional regulator InvF; Provisional; Region: PRK15340 1207075011697 Mga helix-turn-helix domain; Region: Mga; pfam05043 1207075011698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075011699 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1207075011700 NMT1-like family; Region: NMT1_2; pfam13379 1207075011701 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1207075011702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075011703 active site 1207075011704 phosphorylation site [posttranslational modification] 1207075011705 intermolecular recognition site; other site 1207075011706 dimerization interface [polypeptide binding]; other site 1207075011707 ANTAR domain; Region: ANTAR; pfam03861 1207075011708 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1207075011709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075011710 putative substrate translocation pore; other site 1207075011711 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1207075011712 active site 1207075011713 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1207075011714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1207075011715 active site 1207075011716 ATP binding site [chemical binding]; other site 1207075011717 substrate binding site [chemical binding]; other site 1207075011718 activation loop (A-loop); other site 1207075011719 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1207075011720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1207075011721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075011722 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1207075011723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1207075011724 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1207075011725 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1207075011726 [2Fe-2S] cluster binding site [ion binding]; other site 1207075011727 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1207075011728 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1207075011729 [4Fe-4S] binding site [ion binding]; other site 1207075011730 molybdopterin cofactor binding site; other site 1207075011731 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1207075011732 molybdopterin cofactor binding site; other site 1207075011733 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1207075011734 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1207075011735 active site 1207075011736 SAM binding site [chemical binding]; other site 1207075011737 homodimer interface [polypeptide binding]; other site 1207075011738 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1207075011739 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075011740 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075011741 ligand binding site [chemical binding]; other site 1207075011742 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1207075011743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075011744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075011745 DNA binding residues [nucleotide binding] 1207075011746 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1207075011747 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1207075011748 Cl binding site [ion binding]; other site 1207075011749 oligomer interface [polypeptide binding]; other site 1207075011750 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1207075011751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075011752 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1207075011753 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1207075011754 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1207075011755 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1207075011756 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1207075011757 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1207075011758 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1207075011759 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1207075011760 substrate binding site [chemical binding]; other site 1207075011761 ligand binding site [chemical binding]; other site 1207075011762 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1207075011763 substrate binding site [chemical binding]; other site 1207075011764 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1207075011765 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1207075011766 dimer interface [polypeptide binding]; other site 1207075011767 active site 1207075011768 citrylCoA binding site [chemical binding]; other site 1207075011769 oxalacetate/citrate binding site [chemical binding]; other site 1207075011770 coenzyme A binding site [chemical binding]; other site 1207075011771 catalytic triad [active] 1207075011772 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1207075011773 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1207075011774 tetramer interface [polypeptide binding]; other site 1207075011775 active site 1207075011776 Mg2+/Mn2+ binding site [ion binding]; other site 1207075011777 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075011778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075011779 DNA-binding site [nucleotide binding]; DNA binding site 1207075011780 FCD domain; Region: FCD; pfam07729 1207075011781 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1207075011782 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1207075011783 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1207075011784 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1207075011785 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1207075011786 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1207075011787 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1207075011788 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1207075011789 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1207075011790 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1207075011791 Active Sites [active] 1207075011792 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1207075011793 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075011794 Na binding site [ion binding]; other site 1207075011795 putative substrate binding site [chemical binding]; other site 1207075011796 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1207075011797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075011798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075011799 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075011800 putative effector binding pocket; other site 1207075011801 dimerization interface [polypeptide binding]; other site 1207075011802 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075011803 classical (c) SDRs; Region: SDR_c; cd05233 1207075011804 NAD(P) binding site [chemical binding]; other site 1207075011805 active site 1207075011806 hydrolase; Region: PLN02811 1207075011807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075011808 motif II; other site 1207075011809 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1207075011810 RHS Repeat; Region: RHS_repeat; cl11982 1207075011811 RHS Repeat; Region: RHS_repeat; pfam05593 1207075011812 RHS Repeat; Region: RHS_repeat; cl11982 1207075011813 RHS Repeat; Region: RHS_repeat; pfam05593 1207075011814 RHS Repeat; Region: RHS_repeat; pfam05593 1207075011815 RHS Repeat; Region: RHS_repeat; pfam05593 1207075011816 RHS Repeat; Region: RHS_repeat; pfam05593 1207075011817 RHS Repeat; Region: RHS_repeat; pfam05593 1207075011818 RHS protein; Region: RHS; pfam03527 1207075011819 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1207075011820 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1207075011821 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1207075011822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075011823 substrate binding site [chemical binding]; other site 1207075011824 oxyanion hole (OAH) forming residues; other site 1207075011825 trimer interface [polypeptide binding]; other site 1207075011826 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1207075011827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1207075011828 putative acyl-acceptor binding pocket; other site 1207075011829 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1207075011830 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1207075011831 oligomer interface [polypeptide binding]; other site 1207075011832 metal binding site [ion binding]; metal-binding site 1207075011833 metal binding site [ion binding]; metal-binding site 1207075011834 putative Cl binding site [ion binding]; other site 1207075011835 basic sphincter; other site 1207075011836 hydrophobic gate; other site 1207075011837 periplasmic entrance; other site 1207075011838 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1207075011839 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1207075011840 catalytic triad [active] 1207075011841 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1207075011842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075011843 substrate binding site [chemical binding]; other site 1207075011844 oxyanion hole (OAH) forming residues; other site 1207075011845 trimer interface [polypeptide binding]; other site 1207075011846 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1207075011847 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1207075011848 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1207075011849 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1207075011850 dimer interface [polypeptide binding]; other site 1207075011851 active site 1207075011852 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1207075011853 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075011854 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1207075011855 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1207075011856 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1207075011857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1207075011858 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1207075011859 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1207075011860 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1207075011861 spermidine synthase; Provisional; Region: PRK00811 1207075011862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075011863 S-adenosylmethionine binding site [chemical binding]; other site 1207075011864 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1207075011865 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1207075011866 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1207075011867 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1207075011868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075011869 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1207075011870 acyl-activating enzyme (AAE) consensus motif; other site 1207075011871 putative AMP binding site [chemical binding]; other site 1207075011872 putative active site [active] 1207075011873 putative CoA binding site [chemical binding]; other site 1207075011874 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1207075011875 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1207075011876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075011877 motif II; other site 1207075011878 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1207075011879 Cupin domain; Region: Cupin_2; cl17218 1207075011880 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1207075011881 intersubunit interface [polypeptide binding]; other site 1207075011882 active site 1207075011883 Zn2+ binding site [ion binding]; other site 1207075011884 MFS_1 like family; Region: MFS_1_like; pfam12832 1207075011885 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1207075011886 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1207075011887 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1207075011888 Tetramer interface [polypeptide binding]; other site 1207075011889 active site 1207075011890 FMN-binding site [chemical binding]; other site 1207075011891 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1207075011892 HemK family putative methylases; Region: hemK_fam; TIGR00536 1207075011893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075011894 S-adenosylmethionine binding site [chemical binding]; other site 1207075011895 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1207075011896 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075011897 catalytic triad [active] 1207075011898 conserved cis-peptide bond; other site 1207075011899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1207075011900 Smr domain; Region: Smr; pfam01713 1207075011901 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1207075011902 homodecamer interface [polypeptide binding]; other site 1207075011903 GTP cyclohydrolase I; Provisional; Region: PLN03044 1207075011904 active site 1207075011905 putative catalytic site residues [active] 1207075011906 zinc binding site [ion binding]; other site 1207075011907 GTP-CH-I/GFRP interaction surface; other site 1207075011908 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1207075011909 aspartate aminotransferase; Provisional; Region: PRK05764 1207075011910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075011911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075011912 homodimer interface [polypeptide binding]; other site 1207075011913 catalytic residue [active] 1207075011914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1207075011915 MarR family; Region: MarR_2; pfam12802 1207075011916 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1207075011917 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075011918 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1207075011919 active site 1207075011920 homotetramer interface [polypeptide binding]; other site 1207075011921 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1207075011922 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1207075011923 active site 1207075011924 catalytic site [active] 1207075011925 tetramer interface [polypeptide binding]; other site 1207075011926 OHCU decarboxylase; Region: UHCUDC; TIGR03164 1207075011927 allantoicase; Provisional; Region: PRK13257 1207075011928 Allantoicase repeat; Region: Allantoicase; pfam03561 1207075011929 Allantoicase repeat; Region: Allantoicase; pfam03561 1207075011930 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1207075011931 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1207075011932 Predicted membrane protein [Function unknown]; Region: COG3748 1207075011933 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1207075011934 Cytochrome c; Region: Cytochrom_C; pfam00034 1207075011935 xanthine permease; Region: pbuX; TIGR03173 1207075011936 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1207075011937 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1207075011938 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1207075011939 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1207075011940 active site 1207075011941 nucleophile elbow; other site 1207075011942 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1207075011943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1207075011944 putative acyl-acceptor binding pocket; other site 1207075011945 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1207075011946 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1207075011947 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1207075011948 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1207075011949 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1207075011950 Switch I; other site 1207075011951 Switch II; other site 1207075011952 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1207075011953 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1207075011954 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1207075011955 active site 1207075011956 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1207075011957 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1207075011958 active site 1207075011959 metal binding site [ion binding]; metal-binding site 1207075011960 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1207075011961 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075011962 transcriptional regulator protein; Region: phnR; TIGR03337 1207075011963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075011964 DNA-binding site [nucleotide binding]; DNA binding site 1207075011965 UTRA domain; Region: UTRA; pfam07702 1207075011966 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075011967 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075011968 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1207075011969 Sulfatase; Region: Sulfatase; cl17466 1207075011970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075011971 dimer interface [polypeptide binding]; other site 1207075011972 conserved gate region; other site 1207075011973 putative PBP binding loops; other site 1207075011974 ABC-ATPase subunit interface; other site 1207075011975 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075011976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075011977 dimer interface [polypeptide binding]; other site 1207075011978 conserved gate region; other site 1207075011979 ABC-ATPase subunit interface; other site 1207075011980 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075011981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075011982 Walker A/P-loop; other site 1207075011983 ATP binding site [chemical binding]; other site 1207075011984 Q-loop/lid; other site 1207075011985 ABC transporter signature motif; other site 1207075011986 Walker B; other site 1207075011987 D-loop; other site 1207075011988 H-loop/switch region; other site 1207075011989 TOBE domain; Region: TOBE_2; pfam08402 1207075011990 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1207075011991 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1207075011992 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1207075011993 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1207075011994 NAD(P) binding site [chemical binding]; other site 1207075011995 carboxy-terminal protease; Provisional; Region: PRK11186 1207075011996 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1207075011997 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1207075011998 protein binding site [polypeptide binding]; other site 1207075011999 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1207075012000 Catalytic dyad [active] 1207075012001 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1207075012002 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075012003 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1207075012004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075012005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075012006 metal binding site [ion binding]; metal-binding site 1207075012007 active site 1207075012008 I-site; other site 1207075012009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075012010 non-specific DNA binding site [nucleotide binding]; other site 1207075012011 salt bridge; other site 1207075012012 sequence-specific DNA binding site [nucleotide binding]; other site 1207075012013 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1207075012014 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1207075012015 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1207075012016 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075012017 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1207075012018 putative heme binding pocket [chemical binding]; other site 1207075012019 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1207075012020 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1207075012021 Sodium Bile acid symporter family; Region: SBF; pfam01758 1207075012022 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1207075012023 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1207075012024 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1207075012025 putative acyl-acceptor binding pocket; other site 1207075012026 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1207075012027 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1207075012028 gating phenylalanine in ion channel; other site 1207075012029 Cupin domain; Region: Cupin_2; cl17218 1207075012030 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1207075012031 Na binding site [ion binding]; other site 1207075012032 PAS domain; Region: PAS; smart00091 1207075012033 PAS fold; Region: PAS_7; pfam12860 1207075012034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075012035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075012036 dimer interface [polypeptide binding]; other site 1207075012037 phosphorylation site [posttranslational modification] 1207075012038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075012039 ATP binding site [chemical binding]; other site 1207075012040 Mg2+ binding site [ion binding]; other site 1207075012041 G-X-G motif; other site 1207075012042 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075012043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075012044 active site 1207075012045 phosphorylation site [posttranslational modification] 1207075012046 intermolecular recognition site; other site 1207075012047 dimerization interface [polypeptide binding]; other site 1207075012048 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1207075012049 RmuC family; Region: RmuC; pfam02646 1207075012050 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1207075012051 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1207075012052 catalytic residues [active] 1207075012053 dimer interface [polypeptide binding]; other site 1207075012054 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075012055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075012056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075012057 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1207075012058 MarR family; Region: MarR_2; cl17246 1207075012059 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1207075012060 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1207075012061 catalytic core [active] 1207075012062 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1207075012063 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1207075012064 putative dimer interface [polypeptide binding]; other site 1207075012065 active site pocket [active] 1207075012066 putative cataytic base [active] 1207075012067 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1207075012068 homotrimer interface [polypeptide binding]; other site 1207075012069 Walker A motif; other site 1207075012070 GTP binding site [chemical binding]; other site 1207075012071 cobyric acid synthase; Provisional; Region: PRK00784 1207075012072 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1207075012073 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1207075012074 catalytic triad [active] 1207075012075 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1207075012076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075012077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012078 homodimer interface [polypeptide binding]; other site 1207075012079 catalytic residue [active] 1207075012080 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1207075012081 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1207075012082 putative FMN binding site [chemical binding]; other site 1207075012083 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1207075012084 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075012085 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1207075012086 catalytic triad [active] 1207075012087 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1207075012088 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1207075012089 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1207075012090 Walker A motif; other site 1207075012091 homodimer interface [polypeptide binding]; other site 1207075012092 ATP binding site [chemical binding]; other site 1207075012093 hydroxycobalamin binding site [chemical binding]; other site 1207075012094 Walker B motif; other site 1207075012095 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1207075012096 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1207075012097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075012098 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1207075012099 NlpC/P60 family; Region: NLPC_P60; pfam00877 1207075012100 NlpC/P60 family; Region: NLPC_P60; pfam00877 1207075012101 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1207075012102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075012103 Walker A motif; other site 1207075012104 ATP binding site [chemical binding]; other site 1207075012105 Walker B motif; other site 1207075012106 arginine finger; other site 1207075012107 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1207075012108 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1207075012109 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1207075012110 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1207075012111 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1207075012112 dimerization interface [polypeptide binding]; other site 1207075012113 putative ATP binding site [chemical binding]; other site 1207075012114 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1207075012115 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1207075012116 active site 1207075012117 substrate binding site [chemical binding]; other site 1207075012118 cosubstrate binding site; other site 1207075012119 catalytic site [active] 1207075012120 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1207075012121 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1207075012122 Pirin; Region: Pirin; pfam02678 1207075012123 Pirin-related protein [General function prediction only]; Region: COG1741 1207075012124 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1207075012125 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1207075012126 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075012127 heat shock protein 90; Provisional; Region: PRK05218 1207075012128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075012129 ATP binding site [chemical binding]; other site 1207075012130 Mg2+ binding site [ion binding]; other site 1207075012131 G-X-G motif; other site 1207075012132 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075012133 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1207075012134 CoenzymeA binding site [chemical binding]; other site 1207075012135 subunit interaction site [polypeptide binding]; other site 1207075012136 PHB binding site; other site 1207075012137 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075012138 CoenzymeA binding site [chemical binding]; other site 1207075012139 subunit interaction site [polypeptide binding]; other site 1207075012140 PHB binding site; other site 1207075012141 MAPEG family; Region: MAPEG; cl09190 1207075012142 Predicted membrane protein [Function unknown]; Region: COG3821 1207075012143 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1207075012144 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1207075012145 CoA binding domain; Region: CoA_binding; pfam02629 1207075012146 CoA-ligase; Region: Ligase_CoA; pfam00549 1207075012147 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1207075012148 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1207075012149 CoA-ligase; Region: Ligase_CoA; pfam00549 1207075012150 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1207075012151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075012152 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1207075012153 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1207075012154 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075012155 E3 interaction surface; other site 1207075012156 lipoyl attachment site [posttranslational modification]; other site 1207075012157 e3 binding domain; Region: E3_binding; pfam02817 1207075012158 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1207075012159 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1207075012160 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1207075012161 TPP-binding site [chemical binding]; other site 1207075012162 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1207075012163 dimer interface [polypeptide binding]; other site 1207075012164 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1207075012165 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1207075012166 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1207075012167 L-aspartate oxidase; Provisional; Region: PRK06175 1207075012168 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1207075012169 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1207075012170 SdhC subunit interface [polypeptide binding]; other site 1207075012171 proximal heme binding site [chemical binding]; other site 1207075012172 cardiolipin binding site; other site 1207075012173 Iron-sulfur protein interface; other site 1207075012174 proximal quinone binding site [chemical binding]; other site 1207075012175 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1207075012176 Iron-sulfur protein interface; other site 1207075012177 proximal quinone binding site [chemical binding]; other site 1207075012178 SdhD (CybS) interface [polypeptide binding]; other site 1207075012179 proximal heme binding site [chemical binding]; other site 1207075012180 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1207075012181 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1207075012182 dimer interface [polypeptide binding]; other site 1207075012183 active site 1207075012184 citrylCoA binding site [chemical binding]; other site 1207075012185 NADH binding [chemical binding]; other site 1207075012186 cationic pore residues; other site 1207075012187 oxalacetate/citrate binding site [chemical binding]; other site 1207075012188 coenzyme A binding site [chemical binding]; other site 1207075012189 catalytic triad [active] 1207075012190 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1207075012191 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1207075012192 Na binding site [ion binding]; other site 1207075012193 Predicted membrane protein [Function unknown]; Region: COG3162 1207075012194 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075012195 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1207075012196 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1207075012197 VacJ like lipoprotein; Region: VacJ; cl01073 1207075012198 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1207075012199 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1207075012200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075012201 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1207075012202 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1207075012203 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1207075012204 glyoxylate carboligase; Provisional; Region: PRK11269 1207075012205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1207075012206 PYR/PP interface [polypeptide binding]; other site 1207075012207 dimer interface [polypeptide binding]; other site 1207075012208 TPP binding site [chemical binding]; other site 1207075012209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1207075012210 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1207075012211 TPP-binding site [chemical binding]; other site 1207075012212 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1207075012213 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1207075012214 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1207075012215 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1207075012216 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1207075012217 MOFRL family; Region: MOFRL; pfam05161 1207075012218 pyruvate kinase; Provisional; Region: PRK06247 1207075012219 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1207075012220 domain interfaces; other site 1207075012221 active site 1207075012222 Urea transporter; Region: UT; pfam03253 1207075012223 Ion transport protein; Region: Ion_trans; pfam00520 1207075012224 Ion channel; Region: Ion_trans_2; pfam07885 1207075012225 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1207075012226 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1207075012227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075012228 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075012229 DNA binding domain, excisionase family; Region: excise; TIGR01764 1207075012230 PIN domain; Region: PIN_3; pfam13470 1207075012231 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1207075012232 active site 1207075012233 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1207075012234 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1207075012235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075012236 binding surface 1207075012237 TPR motif; other site 1207075012238 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1207075012239 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1207075012240 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1207075012241 catalytic residues [active] 1207075012242 central insert; other site 1207075012243 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1207075012244 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1207075012245 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1207075012246 heme exporter protein CcmC; Region: ccmC; TIGR01191 1207075012247 heme exporter protein CcmB; Region: ccmB; TIGR01190 1207075012248 CcmB protein; Region: CcmB; cl17444 1207075012249 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1207075012250 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1207075012251 Walker A/P-loop; other site 1207075012252 ATP binding site [chemical binding]; other site 1207075012253 Q-loop/lid; other site 1207075012254 ABC transporter signature motif; other site 1207075012255 Walker B; other site 1207075012256 D-loop; other site 1207075012257 H-loop/switch region; other site 1207075012258 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1207075012259 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1207075012260 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1207075012261 rarD protein; Region: rarD; TIGR00688 1207075012262 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1207075012263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075012264 S-adenosylmethionine binding site [chemical binding]; other site 1207075012265 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1207075012266 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1207075012267 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1207075012268 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1207075012269 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1207075012270 putative CheA interaction surface; other site 1207075012271 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1207075012272 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1207075012273 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075012274 P-loop; other site 1207075012275 Magnesium ion binding site [ion binding]; other site 1207075012276 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075012277 Magnesium ion binding site [ion binding]; other site 1207075012278 flagellar motor protein MotD; Reviewed; Region: PRK09038 1207075012279 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1207075012280 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075012281 ligand binding site [chemical binding]; other site 1207075012282 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1207075012283 flagellar motor protein; Reviewed; Region: motC; PRK09109 1207075012284 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1207075012285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075012286 active site 1207075012287 phosphorylation site [posttranslational modification] 1207075012288 intermolecular recognition site; other site 1207075012289 dimerization interface [polypeptide binding]; other site 1207075012290 CheB methylesterase; Region: CheB_methylest; pfam01339 1207075012291 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075012292 putative binding surface; other site 1207075012293 active site 1207075012294 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1207075012295 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1207075012296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075012297 ATP binding site [chemical binding]; other site 1207075012298 Mg2+ binding site [ion binding]; other site 1207075012299 G-X-G motif; other site 1207075012300 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1207075012301 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1207075012302 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1207075012303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075012304 active site 1207075012305 phosphorylation site [posttranslational modification] 1207075012306 intermolecular recognition site; other site 1207075012307 dimerization interface [polypeptide binding]; other site 1207075012308 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1207075012309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075012310 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1207075012311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075012312 DNA binding residues [nucleotide binding] 1207075012313 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1207075012314 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075012315 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1207075012316 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1207075012317 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075012318 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1207075012319 FHIPEP family; Region: FHIPEP; pfam00771 1207075012320 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1207075012321 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1207075012322 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1207075012323 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1207075012324 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1207075012325 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1207075012326 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1207075012327 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1207075012328 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1207075012329 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1207075012330 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1207075012331 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1207075012332 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075012333 putative binding surface; other site 1207075012334 active site 1207075012335 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075012336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075012337 active site 1207075012338 phosphorylation site [posttranslational modification] 1207075012339 intermolecular recognition site; other site 1207075012340 dimerization interface [polypeptide binding]; other site 1207075012341 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1207075012342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1207075012343 anti sigma factor interaction site; other site 1207075012344 regulatory phosphorylation site [posttranslational modification]; other site 1207075012345 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1207075012346 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1207075012347 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1207075012348 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1207075012349 Walker A motif/ATP binding site; other site 1207075012350 Walker B motif; other site 1207075012351 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1207075012352 Flagellar assembly protein FliH; Region: FliH; pfam02108 1207075012353 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1207075012354 MgtE intracellular N domain; Region: MgtE_N; cl15244 1207075012355 FliG C-terminal domain; Region: FliG_C; pfam01706 1207075012356 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1207075012357 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1207075012358 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1207075012359 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1207075012360 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075012361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075012362 active site 1207075012363 phosphorylation site [posttranslational modification] 1207075012364 intermolecular recognition site; other site 1207075012365 dimerization interface [polypeptide binding]; other site 1207075012366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075012367 Walker A motif; other site 1207075012368 ATP binding site [chemical binding]; other site 1207075012369 Walker B motif; other site 1207075012370 arginine finger; other site 1207075012371 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1207075012372 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1207075012373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075012374 dimer interface [polypeptide binding]; other site 1207075012375 phosphorylation site [posttranslational modification] 1207075012376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075012377 ATP binding site [chemical binding]; other site 1207075012378 Mg2+ binding site [ion binding]; other site 1207075012379 G-X-G motif; other site 1207075012380 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075012381 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1207075012382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075012383 Walker A motif; other site 1207075012384 ATP binding site [chemical binding]; other site 1207075012385 Walker B motif; other site 1207075012386 arginine finger; other site 1207075012387 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075012388 flagellar protein FliS; Validated; Region: fliS; PRK05685 1207075012389 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1207075012390 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1207075012391 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1207075012392 FlaG protein; Region: FlaG; pfam03646 1207075012393 flagellin; Provisional; Region: PRK12802 1207075012394 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1207075012395 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1207075012396 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1207075012397 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1207075012398 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1207075012399 dimer interface [polypeptide binding]; other site 1207075012400 active site 1207075012401 CoA binding pocket [chemical binding]; other site 1207075012402 pseudaminic acid synthase; Region: PseI; TIGR03586 1207075012403 NeuB family; Region: NeuB; pfam03102 1207075012404 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1207075012405 NeuB binding interface [polypeptide binding]; other site 1207075012406 putative substrate binding site [chemical binding]; other site 1207075012407 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1207075012408 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1207075012409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1207075012410 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1207075012411 ligand binding site; other site 1207075012412 tetramer interface; other site 1207075012413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075012414 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1207075012415 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1207075012416 inhibitor-cofactor binding pocket; inhibition site 1207075012417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012418 catalytic residue [active] 1207075012419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075012420 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075012421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075012422 active site 1207075012423 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1207075012424 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1207075012425 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1207075012426 putative trimer interface [polypeptide binding]; other site 1207075012427 putative CoA binding site [chemical binding]; other site 1207075012428 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1207075012429 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1207075012430 inhibitor-cofactor binding pocket; inhibition site 1207075012431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012432 catalytic residue [active] 1207075012433 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1207075012434 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1207075012435 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1207075012436 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1207075012437 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1207075012438 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1207075012439 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1207075012440 NAD binding site [chemical binding]; other site 1207075012441 homotetramer interface [polypeptide binding]; other site 1207075012442 homodimer interface [polypeptide binding]; other site 1207075012443 substrate binding site [chemical binding]; other site 1207075012444 active site 1207075012445 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1207075012446 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1207075012447 substrate binding site; other site 1207075012448 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1207075012449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1207075012450 active site 1207075012451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1207075012452 active site 1207075012453 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075012454 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1207075012455 Probable Catalytic site; other site 1207075012456 metal-binding site 1207075012457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075012458 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1207075012459 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 1207075012460 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1207075012461 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1207075012462 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1207075012463 Rod binding protein; Region: Rod-binding; cl01626 1207075012464 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1207075012465 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1207075012466 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1207075012467 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1207075012468 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1207075012469 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1207075012470 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1207075012471 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1207075012472 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1207075012473 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1207075012474 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1207075012475 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1207075012476 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1207075012477 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1207075012478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075012479 putative active site [active] 1207075012480 heme pocket [chemical binding]; other site 1207075012481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075012482 Walker A motif; other site 1207075012483 ATP binding site [chemical binding]; other site 1207075012484 Walker B motif; other site 1207075012485 arginine finger; other site 1207075012486 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1207075012487 cofactor binding site; other site 1207075012488 metal binding site [ion binding]; metal-binding site 1207075012489 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1207075012490 aromatic arch; other site 1207075012491 DCoH dimer interaction site [polypeptide binding]; other site 1207075012492 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1207075012493 DCoH tetramer interaction site [polypeptide binding]; other site 1207075012494 substrate binding site [chemical binding]; other site 1207075012495 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1207075012496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075012497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012498 homodimer interface [polypeptide binding]; other site 1207075012499 catalytic residue [active] 1207075012500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075012501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075012502 putative substrate translocation pore; other site 1207075012503 hypothetical protein; Provisional; Region: PRK09256 1207075012504 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1207075012505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075012506 Transposase; Region: HTH_Tnp_1; pfam01527 1207075012507 putative transposase OrfB; Reviewed; Region: PHA02517 1207075012508 HTH-like domain; Region: HTH_21; pfam13276 1207075012509 Integrase core domain; Region: rve; pfam00665 1207075012510 Integrase core domain; Region: rve_3; pfam13683 1207075012511 aromatic amino acid transporter; Provisional; Region: PRK10238 1207075012512 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1207075012513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075012514 RNA binding surface [nucleotide binding]; other site 1207075012515 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1207075012516 probable active site [active] 1207075012517 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1207075012518 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1207075012519 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1207075012520 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1207075012521 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1207075012522 active site 1207075012523 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1207075012524 intracellular septation protein A; Reviewed; Region: PRK00259 1207075012525 YciI-like protein; Reviewed; Region: PRK11370 1207075012526 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1207075012527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075012528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075012529 active site 1207075012530 phosphorylation site [posttranslational modification] 1207075012531 intermolecular recognition site; other site 1207075012532 dimerization interface [polypeptide binding]; other site 1207075012533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075012534 DNA binding site [nucleotide binding] 1207075012535 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1207075012536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075012537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1207075012538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075012539 ATP binding site [chemical binding]; other site 1207075012540 Mg2+ binding site [ion binding]; other site 1207075012541 G-X-G motif; other site 1207075012542 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1207075012543 putative FMN binding site [chemical binding]; other site 1207075012544 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1207075012545 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1207075012546 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075012547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075012548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075012549 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1207075012550 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1207075012551 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1207075012552 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1207075012553 putative active site [active] 1207075012554 putative metal binding site [ion binding]; other site 1207075012555 Cupin domain; Region: Cupin_2; cl17218 1207075012556 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075012557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075012558 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1207075012559 EamA-like transporter family; Region: EamA; pfam00892 1207075012560 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1207075012561 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1207075012562 MarR family; Region: MarR_2; pfam12802 1207075012563 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1207075012564 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1207075012565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075012566 ATP binding site [chemical binding]; other site 1207075012567 putative Mg++ binding site [ion binding]; other site 1207075012568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075012569 nucleotide binding region [chemical binding]; other site 1207075012570 ATP-binding site [chemical binding]; other site 1207075012571 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1207075012572 HRDC domain; Region: HRDC; pfam00570 1207075012573 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1207075012574 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1207075012575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1207075012576 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1207075012577 HAMP domain; Region: HAMP; pfam00672 1207075012578 dimerization interface [polypeptide binding]; other site 1207075012579 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075012580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075012581 metal binding site [ion binding]; metal-binding site 1207075012582 active site 1207075012583 I-site; other site 1207075012584 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075012585 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075012586 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075012587 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075012588 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075012589 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1207075012590 VCBS repeat; Region: VCBS_repeat; TIGR01965 1207075012591 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1207075012592 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1207075012593 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1207075012594 metal ion-dependent adhesion site (MIDAS); other site 1207075012595 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1207075012596 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1207075012597 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1207075012598 putative active site [active] 1207075012599 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1207075012600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075012601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075012602 Walker A/P-loop; other site 1207075012603 ATP binding site [chemical binding]; other site 1207075012604 Q-loop/lid; other site 1207075012605 ABC transporter signature motif; other site 1207075012606 Walker B; other site 1207075012607 D-loop; other site 1207075012608 H-loop/switch region; other site 1207075012609 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1207075012610 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075012611 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1207075012612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075012613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075012614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075012615 dimerization interface [polypeptide binding]; other site 1207075012616 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1207075012617 agmatinase; Region: agmatinase; TIGR01230 1207075012618 oligomer interface [polypeptide binding]; other site 1207075012619 putative active site [active] 1207075012620 Mn binding site [ion binding]; other site 1207075012621 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1207075012622 SnoaL-like domain; Region: SnoaL_3; pfam13474 1207075012623 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1207075012624 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1207075012625 Na binding site [ion binding]; other site 1207075012626 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1207075012627 Na binding site [ion binding]; other site 1207075012628 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1207075012629 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1207075012630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075012631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075012632 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1207075012633 putative dimerization interface [polypeptide binding]; other site 1207075012634 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1207075012635 EamA-like transporter family; Region: EamA; pfam00892 1207075012636 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1207075012637 S1 domain; Region: S1_2; pfam13509 1207075012638 S1 domain; Region: S1_2; pfam13509 1207075012639 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1207075012640 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1207075012641 helicase 45; Provisional; Region: PTZ00424 1207075012642 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1207075012643 ATP binding site [chemical binding]; other site 1207075012644 Mg++ binding site [ion binding]; other site 1207075012645 motif III; other site 1207075012646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075012647 nucleotide binding region [chemical binding]; other site 1207075012648 ATP-binding site [chemical binding]; other site 1207075012649 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1207075012650 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075012651 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1207075012652 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1207075012653 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1207075012654 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075012655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075012656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075012657 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1207075012658 dimerization interface [polypeptide binding]; other site 1207075012659 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075012660 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075012661 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1207075012662 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1207075012663 active site 1207075012664 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1207075012665 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1207075012666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075012667 Walker A/P-loop; other site 1207075012668 ATP binding site [chemical binding]; other site 1207075012669 Q-loop/lid; other site 1207075012670 ABC transporter signature motif; other site 1207075012671 Walker B; other site 1207075012672 D-loop; other site 1207075012673 H-loop/switch region; other site 1207075012674 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1207075012675 amphipathic channel; other site 1207075012676 Asn-Pro-Ala signature motifs; other site 1207075012677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1207075012678 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1207075012679 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1207075012680 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1207075012681 dimer interface [polypeptide binding]; other site 1207075012682 active site 1207075012683 CoA binding pocket [chemical binding]; other site 1207075012684 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1207075012685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075012686 ATP binding site [chemical binding]; other site 1207075012687 putative Mg++ binding site [ion binding]; other site 1207075012688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075012689 nucleotide binding region [chemical binding]; other site 1207075012690 ATP-binding site [chemical binding]; other site 1207075012691 Helicase associated domain (HA2); Region: HA2; pfam04408 1207075012692 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1207075012693 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1207075012694 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1207075012695 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1207075012696 EamA-like transporter family; Region: EamA; pfam00892 1207075012697 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1207075012698 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1207075012699 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075012700 NADP binding site [chemical binding]; other site 1207075012701 catalytic residues [active] 1207075012702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1207075012703 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1207075012704 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1207075012705 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1207075012706 putative active site pocket [active] 1207075012707 putative metal binding site [ion binding]; other site 1207075012708 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1207075012709 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1207075012710 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1207075012711 Amidohydrolase; Region: Amidohydro_2; pfam04909 1207075012712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075012713 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075012714 putative substrate translocation pore; other site 1207075012715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1207075012716 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1207075012717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1207075012718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075012719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075012720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075012721 dimerization interface [polypeptide binding]; other site 1207075012722 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1207075012723 EamA-like transporter family; Region: EamA; pfam00892 1207075012724 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1207075012725 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1207075012726 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1207075012727 dimer interface [polypeptide binding]; other site 1207075012728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012729 catalytic residue [active] 1207075012730 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1207075012731 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1207075012732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075012733 Walker A motif; other site 1207075012734 ATP binding site [chemical binding]; other site 1207075012735 Walker B motif; other site 1207075012736 arginine finger; other site 1207075012737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1207075012738 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1207075012739 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1207075012740 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1207075012741 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1207075012742 putative active site [active] 1207075012743 benzoate transport; Region: 2A0115; TIGR00895 1207075012744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075012745 putative substrate translocation pore; other site 1207075012746 transcriptional regulator, ArgP family; Region: argP; TIGR03298 1207075012747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075012748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075012749 dimerization interface [polypeptide binding]; other site 1207075012750 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1207075012751 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1207075012752 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1207075012753 putative active site [active] 1207075012754 putative dimer interface [polypeptide binding]; other site 1207075012755 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1207075012756 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075012757 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1207075012758 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075012759 ligand binding site [chemical binding]; other site 1207075012760 flexible hinge region; other site 1207075012761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075012762 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1207075012763 active site 1207075012764 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1207075012765 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1207075012766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1207075012767 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1207075012768 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1207075012769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075012770 FeS/SAM binding site; other site 1207075012771 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1207075012772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075012773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075012774 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1207075012775 active site 1207075012776 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1207075012777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1207075012778 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1207075012779 thymidylate kinase; Validated; Region: tmk; PRK00698 1207075012780 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1207075012781 TMP-binding site; other site 1207075012782 ATP-binding site [chemical binding]; other site 1207075012783 YceG-like family; Region: YceG; pfam02618 1207075012784 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1207075012785 dimerization interface [polypeptide binding]; other site 1207075012786 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1207075012787 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1207075012788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012789 catalytic residue [active] 1207075012790 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1207075012791 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1207075012792 dimer interface [polypeptide binding]; other site 1207075012793 active site 1207075012794 acyl carrier protein; Provisional; Region: acpP; PRK00982 1207075012795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075012796 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1207075012797 NAD(P) binding site [chemical binding]; other site 1207075012798 homotetramer interface [polypeptide binding]; other site 1207075012799 homodimer interface [polypeptide binding]; other site 1207075012800 active site 1207075012801 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1207075012802 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1207075012803 putative phosphate acyltransferase; Provisional; Region: PRK05331 1207075012804 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1207075012805 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1207075012806 Maf-like protein; Region: Maf; pfam02545 1207075012807 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1207075012808 active site 1207075012809 dimer interface [polypeptide binding]; other site 1207075012810 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1207075012811 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1207075012812 tandem repeat interface [polypeptide binding]; other site 1207075012813 oligomer interface [polypeptide binding]; other site 1207075012814 active site residues [active] 1207075012815 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1207075012816 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1207075012817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075012818 motif II; other site 1207075012819 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1207075012820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075012821 RNA binding surface [nucleotide binding]; other site 1207075012822 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1207075012823 active site 1207075012824 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1207075012825 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1207075012826 homodimer interface [polypeptide binding]; other site 1207075012827 oligonucleotide binding site [chemical binding]; other site 1207075012828 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1207075012829 Ligand binding site; other site 1207075012830 metal-binding site 1207075012831 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1207075012832 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1207075012833 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1207075012834 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1207075012835 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075012836 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1207075012837 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1207075012838 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1207075012839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075012840 catalytic loop [active] 1207075012841 iron binding site [ion binding]; other site 1207075012842 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1207075012843 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1207075012844 FAD binding domain; Region: FAD_binding_4; pfam01565 1207075012845 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1207075012846 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1207075012847 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1207075012848 active site 1207075012849 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1207075012850 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1207075012851 Ligand binding site; other site 1207075012852 oligomer interface; other site 1207075012853 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1207075012854 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1207075012855 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1207075012856 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1207075012857 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1207075012858 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1207075012859 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1207075012860 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1207075012861 Competence protein; Region: Competence; pfam03772 1207075012862 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1207075012863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1207075012864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 1207075012865 inner membrane transport permease; Provisional; Region: PRK15066 1207075012866 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1207075012867 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1207075012868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075012869 Walker A/P-loop; other site 1207075012870 ATP binding site [chemical binding]; other site 1207075012871 Q-loop/lid; other site 1207075012872 ABC transporter signature motif; other site 1207075012873 Walker B; other site 1207075012874 D-loop; other site 1207075012875 H-loop/switch region; other site 1207075012876 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075012877 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1207075012878 putative C-terminal domain interface [polypeptide binding]; other site 1207075012879 putative GSH binding site (G-site) [chemical binding]; other site 1207075012880 putative dimer interface [polypeptide binding]; other site 1207075012881 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1207075012882 putative N-terminal domain interface [polypeptide binding]; other site 1207075012883 putative dimer interface [polypeptide binding]; other site 1207075012884 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075012885 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1207075012886 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1207075012887 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1207075012888 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1207075012889 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1207075012890 active site 1207075012891 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1207075012892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075012893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075012894 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075012895 putative effector binding pocket; other site 1207075012896 dimerization interface [polypeptide binding]; other site 1207075012897 alanine-tRNA ligase; Region: PLN02961 1207075012898 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1207075012899 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1207075012900 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1207075012901 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1207075012902 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1207075012903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075012904 TPR motif; other site 1207075012905 binding surface 1207075012906 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1207075012907 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1207075012908 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1207075012909 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1207075012910 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1207075012911 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1207075012912 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1207075012913 ATP binding site [chemical binding]; other site 1207075012914 Walker A motif; other site 1207075012915 hexamer interface [polypeptide binding]; other site 1207075012916 Walker B motif; other site 1207075012917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1207075012918 active site 1207075012919 dimerization interface [polypeptide binding]; other site 1207075012920 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1207075012921 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1207075012922 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1207075012923 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1207075012924 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1207075012925 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1207075012926 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1207075012927 RNA helicase; Region: RNA_helicase; pfam00910 1207075012928 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1207075012929 Flp/Fap pilin component; Region: Flp_Fap; cl01585 1207075012930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1207075012931 intermolecular recognition site; other site 1207075012932 active site 1207075012933 dimerization interface [polypeptide binding]; other site 1207075012934 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075012935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075012936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075012937 dimerization interface [polypeptide binding]; other site 1207075012938 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075012939 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075012940 dimer interface [polypeptide binding]; other site 1207075012941 putative CheW interface [polypeptide binding]; other site 1207075012942 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075012943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075012944 DNA-binding site [nucleotide binding]; DNA binding site 1207075012945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075012946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075012947 homodimer interface [polypeptide binding]; other site 1207075012948 catalytic residue [active] 1207075012949 short chain dehydrogenase; Provisional; Region: PRK06172 1207075012950 classical (c) SDRs; Region: SDR_c; cd05233 1207075012951 NAD(P) binding site [chemical binding]; other site 1207075012952 active site 1207075012953 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1207075012954 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1207075012955 NAD(P) binding site [chemical binding]; other site 1207075012956 substrate binding site [chemical binding]; other site 1207075012957 dimer interface [polypeptide binding]; other site 1207075012958 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1207075012959 active site 1207075012960 dimer interface [polypeptide binding]; other site 1207075012961 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1207075012962 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1207075012963 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1207075012964 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1207075012965 C-terminal domain interface [polypeptide binding]; other site 1207075012966 GSH binding site (G-site) [chemical binding]; other site 1207075012967 dimer interface [polypeptide binding]; other site 1207075012968 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1207075012969 N-terminal domain interface [polypeptide binding]; other site 1207075012970 dimer interface [polypeptide binding]; other site 1207075012971 substrate binding pocket (H-site) [chemical binding]; other site 1207075012972 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1207075012973 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075012974 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1207075012975 CoenzymeA binding site [chemical binding]; other site 1207075012976 subunit interaction site [polypeptide binding]; other site 1207075012977 PHB binding site; other site 1207075012978 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1207075012979 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 1207075012980 acyl-activating enzyme (AAE) consensus motif; other site 1207075012981 putative AMP binding site [chemical binding]; other site 1207075012982 putative active site [active] 1207075012983 putative CoA binding site [chemical binding]; other site 1207075012984 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1207075012985 catalytic core [active] 1207075012986 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1207075012987 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1207075012988 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1207075012989 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1207075012990 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1207075012991 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1207075012992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075012993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075012994 dimerization interface [polypeptide binding]; other site 1207075012995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075012996 dimer interface [polypeptide binding]; other site 1207075012997 phosphorylation site [posttranslational modification] 1207075012998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075012999 ATP binding site [chemical binding]; other site 1207075013000 Mg2+ binding site [ion binding]; other site 1207075013001 G-X-G motif; other site 1207075013002 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075013003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013004 active site 1207075013005 phosphorylation site [posttranslational modification] 1207075013006 intermolecular recognition site; other site 1207075013007 dimerization interface [polypeptide binding]; other site 1207075013008 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1207075013009 active site 1 [active] 1207075013010 dimer interface [polypeptide binding]; other site 1207075013011 active site 2 [active] 1207075013012 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1207075013013 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1207075013014 dimer interface [polypeptide binding]; other site 1207075013015 active site 1207075013016 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1207075013017 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1207075013018 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1207075013019 homodimer interface [polypeptide binding]; other site 1207075013020 metal binding site [ion binding]; metal-binding site 1207075013021 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1207075013022 homodimer interface [polypeptide binding]; other site 1207075013023 active site 1207075013024 putative chemical substrate binding site [chemical binding]; other site 1207075013025 metal binding site [ion binding]; metal-binding site 1207075013026 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1207075013027 HD domain; Region: HD_4; pfam13328 1207075013028 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1207075013029 synthetase active site [active] 1207075013030 NTP binding site [chemical binding]; other site 1207075013031 metal binding site [ion binding]; metal-binding site 1207075013032 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1207075013033 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1207075013034 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1207075013035 TRAM domain; Region: TRAM; pfam01938 1207075013036 cysteine synthase B; Region: cysM; TIGR01138 1207075013037 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1207075013038 dimer interface [polypeptide binding]; other site 1207075013039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013040 catalytic residue [active] 1207075013041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075013042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075013043 dimerization interface [polypeptide binding]; other site 1207075013044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075013045 dimer interface [polypeptide binding]; other site 1207075013046 phosphorylation site [posttranslational modification] 1207075013047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013048 ATP binding site [chemical binding]; other site 1207075013049 Mg2+ binding site [ion binding]; other site 1207075013050 G-X-G motif; other site 1207075013051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075013052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013053 active site 1207075013054 phosphorylation site [posttranslational modification] 1207075013055 intermolecular recognition site; other site 1207075013056 dimerization interface [polypeptide binding]; other site 1207075013057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075013058 DNA binding site [nucleotide binding] 1207075013059 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1207075013060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075013061 dimerization interface [polypeptide binding]; other site 1207075013062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075013063 dimer interface [polypeptide binding]; other site 1207075013064 phosphorylation site [posttranslational modification] 1207075013065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013066 ATP binding site [chemical binding]; other site 1207075013067 Mg2+ binding site [ion binding]; other site 1207075013068 G-X-G motif; other site 1207075013069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013070 active site 1207075013071 phosphorylation site [posttranslational modification] 1207075013072 intermolecular recognition site; other site 1207075013073 dimerization interface [polypeptide binding]; other site 1207075013074 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075013075 putative binding surface; other site 1207075013076 active site 1207075013077 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1207075013078 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1207075013079 putative ligand binding site [chemical binding]; other site 1207075013080 putative NAD binding site [chemical binding]; other site 1207075013081 catalytic site [active] 1207075013082 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1207075013083 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1207075013084 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1207075013085 catalytic residues [active] 1207075013086 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1207075013087 ArsC family; Region: ArsC; pfam03960 1207075013088 catalytic residues [active] 1207075013089 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1207075013090 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075013091 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 1207075013092 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1207075013093 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1207075013094 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1207075013095 Ligand Binding Site [chemical binding]; other site 1207075013096 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1207075013097 hypothetical protein; Provisional; Region: PRK04860 1207075013098 SprT homologues; Region: SprT; cl01182 1207075013099 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075013100 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075013101 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1207075013102 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075013103 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075013104 Helix-turn-helix domain; Region: HTH_18; pfam12833 1207075013105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075013106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1207075013107 dimer interface [polypeptide binding]; other site 1207075013108 phosphorylation site [posttranslational modification] 1207075013109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013110 ATP binding site [chemical binding]; other site 1207075013111 Mg2+ binding site [ion binding]; other site 1207075013112 G-X-G motif; other site 1207075013113 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1207075013114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013115 active site 1207075013116 phosphorylation site [posttranslational modification] 1207075013117 intermolecular recognition site; other site 1207075013118 dimerization interface [polypeptide binding]; other site 1207075013119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075013120 DNA binding site [nucleotide binding] 1207075013121 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1207075013122 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1207075013123 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1207075013124 sensor protein RstB; Provisional; Region: PRK10604 1207075013125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075013126 dimerization interface [polypeptide binding]; other site 1207075013127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075013128 dimer interface [polypeptide binding]; other site 1207075013129 phosphorylation site [posttranslational modification] 1207075013130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013131 ATP binding site [chemical binding]; other site 1207075013132 Mg2+ binding site [ion binding]; other site 1207075013133 G-X-G motif; other site 1207075013134 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1207075013135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013136 active site 1207075013137 phosphorylation site [posttranslational modification] 1207075013138 intermolecular recognition site; other site 1207075013139 dimerization interface [polypeptide binding]; other site 1207075013140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075013141 DNA binding site [nucleotide binding] 1207075013142 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1207075013143 ATP cone domain; Region: ATP-cone; pfam03477 1207075013144 ATP cone domain; Region: ATP-cone; pfam03477 1207075013145 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1207075013146 active site 1207075013147 dimer interface [polypeptide binding]; other site 1207075013148 catalytic residues [active] 1207075013149 effector binding site; other site 1207075013150 R2 peptide binding site; other site 1207075013151 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1207075013152 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1207075013153 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1207075013154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1207075013155 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1207075013156 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1207075013157 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1207075013158 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1207075013159 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1207075013160 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1207075013161 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1207075013162 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1207075013163 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1207075013164 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1207075013165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075013166 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1207075013167 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075013168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013169 active site 1207075013170 phosphorylation site [posttranslational modification] 1207075013171 intermolecular recognition site; other site 1207075013172 dimerization interface [polypeptide binding]; other site 1207075013173 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1207075013174 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1207075013175 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1207075013176 FlgN protein; Region: FlgN; pfam05130 1207075013177 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1207075013178 PilZ domain; Region: PilZ; pfam07238 1207075013179 putative MFS family transporter protein; Provisional; Region: PRK03633 1207075013180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075013181 putative substrate translocation pore; other site 1207075013182 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075013183 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075013184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075013185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013186 ATP binding site [chemical binding]; other site 1207075013187 Mg2+ binding site [ion binding]; other site 1207075013188 G-X-G motif; other site 1207075013189 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1207075013190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013191 active site 1207075013192 phosphorylation site [posttranslational modification] 1207075013193 intermolecular recognition site; other site 1207075013194 dimerization interface [polypeptide binding]; other site 1207075013195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1207075013196 binding surface 1207075013197 TPR motif; other site 1207075013198 TPR repeat; Region: TPR_11; pfam13414 1207075013199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075013200 binding surface 1207075013201 TPR motif; other site 1207075013202 TPR repeat; Region: TPR_11; pfam13414 1207075013203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075013204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075013205 DNA binding residues [nucleotide binding] 1207075013206 dimerization interface [polypeptide binding]; other site 1207075013207 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1207075013208 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1207075013209 E3 interaction surface; other site 1207075013210 lipoyl attachment site [posttranslational modification]; other site 1207075013211 e3 binding domain; Region: E3_binding; pfam02817 1207075013212 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1207075013213 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1207075013214 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1207075013215 dimer interface [polypeptide binding]; other site 1207075013216 TPP-binding site [chemical binding]; other site 1207075013217 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1207075013218 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1207075013219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013220 catalytic residue [active] 1207075013221 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1207075013222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075013223 putative DNA binding site [nucleotide binding]; other site 1207075013224 putative Zn2+ binding site [ion binding]; other site 1207075013225 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075013226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075013227 Zn2+ binding site [ion binding]; other site 1207075013228 Mg2+ binding site [ion binding]; other site 1207075013229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075013230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075013231 DNA binding residues [nucleotide binding] 1207075013232 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1207075013233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075013234 Arc-like DNA binding domain; Region: Arc; pfam03869 1207075013235 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1207075013236 MgtE intracellular N domain; Region: MgtE_N; smart00924 1207075013237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1207075013238 Divalent cation transporter; Region: MgtE; cl00786 1207075013239 carbon storage regulator; Provisional; Region: PRK01712 1207075013240 aspartate kinase; Reviewed; Region: PRK06635 1207075013241 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1207075013242 putative nucleotide binding site [chemical binding]; other site 1207075013243 putative catalytic residues [active] 1207075013244 putative Mg ion binding site [ion binding]; other site 1207075013245 putative aspartate binding site [chemical binding]; other site 1207075013246 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1207075013247 putative allosteric regulatory site; other site 1207075013248 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1207075013249 putative allosteric regulatory residue; other site 1207075013250 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1207075013251 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1207075013252 motif 1; other site 1207075013253 active site 1207075013254 motif 2; other site 1207075013255 motif 3; other site 1207075013256 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1207075013257 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1207075013258 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1207075013259 tetramer interface [polypeptide binding]; other site 1207075013260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013261 catalytic residue [active] 1207075013262 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 1207075013263 active site 1207075013264 homopentamer interface [polypeptide binding]; other site 1207075013265 dimer interface [polypeptide binding]; other site 1207075013266 succinylglutamate desuccinylase; Provisional; Region: PRK05324 1207075013267 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1207075013268 active site 1207075013269 Zn binding site [ion binding]; other site 1207075013270 succinylarginine dihydrolase; Provisional; Region: PRK13281 1207075013271 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1207075013272 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1207075013273 NAD(P) binding site [chemical binding]; other site 1207075013274 catalytic residues [active] 1207075013275 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1207075013276 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 1207075013277 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1207075013278 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1207075013279 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1207075013280 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075013281 inhibitor-cofactor binding pocket; inhibition site 1207075013282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013283 catalytic residue [active] 1207075013284 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1207075013285 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1207075013286 Leucine rich repeat; Region: LRR_8; pfam13855 1207075013287 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1207075013288 conserved cys residue [active] 1207075013289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075013290 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075013291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075013292 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1207075013293 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075013294 Walker A/P-loop; other site 1207075013295 ATP binding site [chemical binding]; other site 1207075013296 Q-loop/lid; other site 1207075013297 ABC transporter signature motif; other site 1207075013298 Walker B; other site 1207075013299 D-loop; other site 1207075013300 H-loop/switch region; other site 1207075013301 Predicted deacylase [General function prediction only]; Region: COG3608 1207075013302 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1207075013303 active site 1207075013304 Zn binding site [ion binding]; other site 1207075013305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075013306 dimer interface [polypeptide binding]; other site 1207075013307 conserved gate region; other site 1207075013308 putative PBP binding loops; other site 1207075013309 ABC-ATPase subunit interface; other site 1207075013310 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075013311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075013312 dimer interface [polypeptide binding]; other site 1207075013313 conserved gate region; other site 1207075013314 putative PBP binding loops; other site 1207075013315 ABC-ATPase subunit interface; other site 1207075013316 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075013317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075013318 substrate binding pocket [chemical binding]; other site 1207075013319 membrane-bound complex binding site; other site 1207075013320 hinge residues; other site 1207075013321 acetyl-CoA synthetase; Provisional; Region: PRK00174 1207075013322 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1207075013323 active site 1207075013324 CoA binding site [chemical binding]; other site 1207075013325 acyl-activating enzyme (AAE) consensus motif; other site 1207075013326 AMP binding site [chemical binding]; other site 1207075013327 acetate binding site [chemical binding]; other site 1207075013328 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1207075013329 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1207075013330 dimer interface [polypeptide binding]; other site 1207075013331 putative radical transfer pathway; other site 1207075013332 diiron center [ion binding]; other site 1207075013333 tyrosyl radical; other site 1207075013334 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1207075013335 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1207075013336 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1207075013337 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1207075013338 cofactor binding site; other site 1207075013339 DNA binding site [nucleotide binding] 1207075013340 substrate interaction site [chemical binding]; other site 1207075013341 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1207075013342 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1207075013343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075013344 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1207075013345 BRO family, N-terminal domain; Region: Bro-N; smart01040 1207075013346 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1207075013347 active site 1207075013348 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1207075013349 additional DNA contacts [nucleotide binding]; other site 1207075013350 mismatch recognition site; other site 1207075013351 active site 1207075013352 zinc binding site [ion binding]; other site 1207075013353 DNA intercalation site [nucleotide binding]; other site 1207075013354 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1207075013355 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1207075013356 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1207075013357 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1207075013358 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1207075013359 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1207075013360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075013361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075013362 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1207075013363 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1207075013364 MASE2 domain; Region: MASE2; pfam05230 1207075013365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075013366 metal binding site [ion binding]; metal-binding site 1207075013367 active site 1207075013368 I-site; other site 1207075013369 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1207075013370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075013371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075013372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075013373 dimerization interface [polypeptide binding]; other site 1207075013374 hypothetical protein; Validated; Region: PRK06186 1207075013375 conserved cys residue [active] 1207075013376 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1207075013377 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1207075013378 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1207075013379 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1207075013380 active site 1207075013381 catalytic site [active] 1207075013382 metal binding site [ion binding]; metal-binding site 1207075013383 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1207075013384 HAMP domain; Region: HAMP; pfam00672 1207075013385 dimerization interface [polypeptide binding]; other site 1207075013386 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075013387 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075013388 dimer interface [polypeptide binding]; other site 1207075013389 putative CheW interface [polypeptide binding]; other site 1207075013390 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1207075013391 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1207075013392 Cl binding site [ion binding]; other site 1207075013393 oligomer interface [polypeptide binding]; other site 1207075013394 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1207075013395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1207075013396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075013397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075013398 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1207075013399 putative effector binding pocket; other site 1207075013400 putative dimerization interface [polypeptide binding]; other site 1207075013401 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1207075013402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075013403 NAD(P) binding site [chemical binding]; other site 1207075013404 active site 1207075013405 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1207075013406 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1207075013407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075013408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075013409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075013410 dimerization interface [polypeptide binding]; other site 1207075013411 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1207075013412 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075013413 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1207075013414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1207075013415 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1207075013416 SnoaL-like domain; Region: SnoaL_3; pfam13474 1207075013417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075013418 Coenzyme A binding pocket [chemical binding]; other site 1207075013419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1207075013420 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075013421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075013422 Coenzyme A binding pocket [chemical binding]; other site 1207075013423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1207075013424 LysE type translocator; Region: LysE; cl00565 1207075013425 aminotransferase; Validated; Region: PRK08175 1207075013426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075013427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013428 homodimer interface [polypeptide binding]; other site 1207075013429 catalytic residue [active] 1207075013430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075013431 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075013432 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1207075013433 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075013434 GntP family permease; Region: GntP_permease; pfam02447 1207075013435 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1207075013436 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1207075013437 AAA domain; Region: AAA_33; pfam13671 1207075013438 ATP-binding site [chemical binding]; other site 1207075013439 Gluconate-6-phosphate binding site [chemical binding]; other site 1207075013440 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1207075013441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1207075013442 DNA binding site [nucleotide binding] 1207075013443 domain linker motif; other site 1207075013444 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1207075013445 putative ligand binding site [chemical binding]; other site 1207075013446 putative dimerization interface [polypeptide binding]; other site 1207075013447 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075013448 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1207075013449 putative C-terminal domain interface [polypeptide binding]; other site 1207075013450 putative GSH binding site (G-site) [chemical binding]; other site 1207075013451 putative dimer interface [polypeptide binding]; other site 1207075013452 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1207075013453 putative N-terminal domain interface [polypeptide binding]; other site 1207075013454 putative dimer interface [polypeptide binding]; other site 1207075013455 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075013456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075013457 PAS domain; Region: PAS_9; pfam13426 1207075013458 putative active site [active] 1207075013459 heme pocket [chemical binding]; other site 1207075013460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075013461 PAS domain; Region: PAS_9; pfam13426 1207075013462 putative active site [active] 1207075013463 heme pocket [chemical binding]; other site 1207075013464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075013465 dimer interface [polypeptide binding]; other site 1207075013466 putative CheW interface [polypeptide binding]; other site 1207075013467 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075013468 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1207075013469 RNA polymerase sigma factor; Provisional; Region: PRK12525 1207075013470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075013471 DNA binding residues [nucleotide binding] 1207075013472 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1207075013473 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 1207075013474 putative di-iron ligands [ion binding]; other site 1207075013475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075013476 Coenzyme A binding pocket [chemical binding]; other site 1207075013477 Transposase; Region: HTH_Tnp_1; pfam01527 1207075013478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075013479 putative transposase OrfB; Reviewed; Region: PHA02517 1207075013480 HTH-like domain; Region: HTH_21; pfam13276 1207075013481 Integrase core domain; Region: rve; pfam00665 1207075013482 Integrase core domain; Region: rve_3; pfam13683 1207075013483 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1207075013484 active site 1207075013485 catalytic residues [active] 1207075013486 metal binding site [ion binding]; metal-binding site 1207075013487 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1207075013488 CsbD-like; Region: CsbD; pfam05532 1207075013489 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1207075013490 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1207075013491 acyl-activating enzyme (AAE) consensus motif; other site 1207075013492 putative AMP binding site [chemical binding]; other site 1207075013493 putative active site [active] 1207075013494 putative CoA binding site [chemical binding]; other site 1207075013495 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1207075013496 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1207075013497 acyl-activating enzyme (AAE) consensus motif; other site 1207075013498 putative AMP binding site [chemical binding]; other site 1207075013499 putative active site [active] 1207075013500 putative CoA binding site [chemical binding]; other site 1207075013501 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1207075013502 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075013503 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1207075013504 dimer interaction site [polypeptide binding]; other site 1207075013505 substrate-binding tunnel; other site 1207075013506 active site 1207075013507 catalytic site [active] 1207075013508 substrate binding site [chemical binding]; other site 1207075013509 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1207075013510 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1207075013511 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1207075013512 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1207075013513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1207075013514 catalytic residue [active] 1207075013515 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1207075013516 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1207075013517 active site 1207075013518 intersubunit interface [polypeptide binding]; other site 1207075013519 catalytic residue [active] 1207075013520 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1207075013521 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1207075013522 putative active site [active] 1207075013523 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1207075013524 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1207075013525 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1207075013526 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1207075013527 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1207075013528 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1207075013529 putative active site [active] 1207075013530 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1207075013531 active site 1207075013532 phosphate binding residues; other site 1207075013533 catalytic residues [active] 1207075013534 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1207075013535 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1207075013536 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1207075013537 Walker A/P-loop; other site 1207075013538 ATP binding site [chemical binding]; other site 1207075013539 Q-loop/lid; other site 1207075013540 ABC transporter signature motif; other site 1207075013541 Walker B; other site 1207075013542 D-loop; other site 1207075013543 H-loop/switch region; other site 1207075013544 TOBE domain; Region: TOBE; pfam03459 1207075013545 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1207075013546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075013547 dimer interface [polypeptide binding]; other site 1207075013548 conserved gate region; other site 1207075013549 putative PBP binding loops; other site 1207075013550 ABC-ATPase subunit interface; other site 1207075013551 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075013552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075013553 dimer interface [polypeptide binding]; other site 1207075013554 conserved gate region; other site 1207075013555 putative PBP binding loops; other site 1207075013556 ABC-ATPase subunit interface; other site 1207075013557 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1207075013558 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1207075013559 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1207075013560 putative active cleft [active] 1207075013561 dimerization interface [polypeptide binding]; other site 1207075013562 HAMP domain; Region: HAMP; pfam00672 1207075013563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013564 ATP binding site [chemical binding]; other site 1207075013565 Mg2+ binding site [ion binding]; other site 1207075013566 G-X-G motif; other site 1207075013567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075013568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013569 active site 1207075013570 phosphorylation site [posttranslational modification] 1207075013571 intermolecular recognition site; other site 1207075013572 dimerization interface [polypeptide binding]; other site 1207075013573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075013574 DNA binding site [nucleotide binding] 1207075013575 glucokinase; Provisional; Region: glk; PRK00292 1207075013576 glucokinase, proteobacterial type; Region: glk; TIGR00749 1207075013577 phosphogluconate dehydratase; Validated; Region: PRK09054 1207075013578 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1207075013579 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1207075013580 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1207075013581 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1207075013582 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1207075013583 active site 1207075013584 dimer interfaces [polypeptide binding]; other site 1207075013585 catalytic residues [active] 1207075013586 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1207075013587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075013588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075013589 DNA binding residues [nucleotide binding] 1207075013590 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1207075013591 FecR protein; Region: FecR; pfam04773 1207075013592 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075013593 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1207075013594 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075013595 N-terminal plug; other site 1207075013596 ligand-binding site [chemical binding]; other site 1207075013597 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1207075013598 heme binding pocket [chemical binding]; other site 1207075013599 heme ligand [chemical binding]; other site 1207075013600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1207075013601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075013602 dimerization interface [polypeptide binding]; other site 1207075013603 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075013604 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075013605 dimer interface [polypeptide binding]; other site 1207075013606 putative CheW interface [polypeptide binding]; other site 1207075013607 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075013608 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075013609 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1207075013610 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1207075013611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1207075013612 minor groove reading motif; other site 1207075013613 helix-hairpin-helix signature motif; other site 1207075013614 substrate binding pocket [chemical binding]; other site 1207075013615 active site 1207075013616 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1207075013617 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1207075013618 arginine deiminase; Provisional; Region: PRK01388 1207075013619 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1207075013620 ornithine carbamoyltransferase; Validated; Region: PRK02102 1207075013621 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1207075013622 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1207075013623 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1207075013624 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1207075013625 putative substrate binding site [chemical binding]; other site 1207075013626 nucleotide binding site [chemical binding]; other site 1207075013627 nucleotide binding site [chemical binding]; other site 1207075013628 homodimer interface [polypeptide binding]; other site 1207075013629 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1207075013630 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1207075013631 putative aromatic amino acid binding site; other site 1207075013632 PAS domain; Region: PAS; smart00091 1207075013633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075013634 Walker A motif; other site 1207075013635 ATP binding site [chemical binding]; other site 1207075013636 Walker B motif; other site 1207075013637 arginine finger; other site 1207075013638 glycine cleavage system protein H; Provisional; Region: PRK13380 1207075013639 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1207075013640 lipoyl attachment site [posttranslational modification]; other site 1207075013641 glycine dehydrogenase; Provisional; Region: PRK05367 1207075013642 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1207075013643 tetramer interface [polypeptide binding]; other site 1207075013644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013645 catalytic residue [active] 1207075013646 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1207075013647 tetramer interface [polypeptide binding]; other site 1207075013648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075013649 catalytic residue [active] 1207075013650 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1207075013651 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1207075013652 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1207075013653 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1207075013654 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1207075013655 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1207075013656 DNA-binding site [nucleotide binding]; DNA binding site 1207075013657 RNA-binding motif; other site 1207075013658 RDD family; Region: RDD; pfam06271 1207075013659 quinolinate synthetase; Provisional; Region: PRK09375 1207075013660 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1207075013661 Ligand Binding Site [chemical binding]; other site 1207075013662 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1207075013663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075013664 FeS/SAM binding site; other site 1207075013665 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1207075013666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1207075013667 binding surface 1207075013668 TPR motif; other site 1207075013669 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075013670 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075013671 ligand binding site [chemical binding]; other site 1207075013672 translocation protein TolB; Provisional; Region: tolB; PRK00178 1207075013673 TolB amino-terminal domain; Region: TolB_N; pfam04052 1207075013674 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1207075013675 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1207075013676 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1207075013677 TolA protein; Region: tolA_full; TIGR02794 1207075013678 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1207075013679 TolR protein; Region: tolR; TIGR02801 1207075013680 TolQ protein; Region: tolQ; TIGR02796 1207075013681 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1207075013682 active site 1207075013683 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1207075013684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075013685 Walker A motif; other site 1207075013686 ATP binding site [chemical binding]; other site 1207075013687 Walker B motif; other site 1207075013688 arginine finger; other site 1207075013689 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1207075013690 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1207075013691 RuvA N terminal domain; Region: RuvA_N; pfam01330 1207075013692 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1207075013693 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1207075013694 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1207075013695 active site 1207075013696 putative DNA-binding cleft [nucleotide binding]; other site 1207075013697 dimer interface [polypeptide binding]; other site 1207075013698 hypothetical protein; Validated; Region: PRK00110 1207075013699 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1207075013700 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1207075013701 dimer interface [polypeptide binding]; other site 1207075013702 anticodon binding site; other site 1207075013703 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1207075013704 homodimer interface [polypeptide binding]; other site 1207075013705 motif 1; other site 1207075013706 active site 1207075013707 motif 2; other site 1207075013708 GAD domain; Region: GAD; pfam02938 1207075013709 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1207075013710 active site 1207075013711 motif 3; other site 1207075013712 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1207075013713 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1207075013714 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1207075013715 DNA-binding site [nucleotide binding]; DNA binding site 1207075013716 RNA-binding motif; other site 1207075013717 hypothetical protein; Provisional; Region: PRK00295 1207075013718 HIT domain; Region: HIT; pfam01230 1207075013719 HIT family signature motif; other site 1207075013720 catalytic residue [active] 1207075013721 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075013722 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075013723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1207075013724 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1207075013725 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1207075013726 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1207075013727 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1207075013728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075013729 dimerization interface [polypeptide binding]; other site 1207075013730 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1207075013731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075013732 putative active site [active] 1207075013733 heme pocket [chemical binding]; other site 1207075013734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075013735 dimer interface [polypeptide binding]; other site 1207075013736 phosphorylation site [posttranslational modification] 1207075013737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013738 ATP binding site [chemical binding]; other site 1207075013739 Mg2+ binding site [ion binding]; other site 1207075013740 G-X-G motif; other site 1207075013741 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1207075013742 hypothetical protein; Provisional; Region: PRK08999 1207075013743 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1207075013744 active site 1207075013745 8-oxo-dGMP binding site [chemical binding]; other site 1207075013746 nudix motif; other site 1207075013747 metal binding site [ion binding]; metal-binding site 1207075013748 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1207075013749 thiamine phosphate binding site [chemical binding]; other site 1207075013750 active site 1207075013751 pyrophosphate binding site [ion binding]; other site 1207075013752 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1207075013753 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075013754 putative C-terminal domain interface [polypeptide binding]; other site 1207075013755 putative GSH binding site (G-site) [chemical binding]; other site 1207075013756 putative dimer interface [polypeptide binding]; other site 1207075013757 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1207075013758 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075013759 putative N-terminal domain interface [polypeptide binding]; other site 1207075013760 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1207075013761 heterotetramer interface [polypeptide binding]; other site 1207075013762 active site pocket [active] 1207075013763 cleavage site 1207075013764 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1207075013765 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1207075013766 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1207075013767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1207075013768 nucleotide binding region [chemical binding]; other site 1207075013769 ATP-binding site [chemical binding]; other site 1207075013770 SEC-C motif; Region: SEC-C; pfam02810 1207075013771 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1207075013772 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1207075013773 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 1207075013774 Cache domain; Region: Cache_1; pfam02743 1207075013775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075013776 dimerization interface [polypeptide binding]; other site 1207075013777 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075013778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075013779 dimer interface [polypeptide binding]; other site 1207075013780 putative CheW interface [polypeptide binding]; other site 1207075013781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1207075013782 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1207075013783 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1207075013784 Predicted deacetylase [General function prediction only]; Region: COG3233 1207075013785 putative active site [active] 1207075013786 putative Zn binding site [ion binding]; other site 1207075013787 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1207075013788 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1207075013789 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1207075013790 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1207075013791 putative active site [active] 1207075013792 putative substrate binding site [chemical binding]; other site 1207075013793 putative cosubstrate binding site; other site 1207075013794 catalytic site [active] 1207075013795 exonuclease I; Provisional; Region: sbcB; PRK11779 1207075013796 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1207075013797 active site 1207075013798 catalytic site [active] 1207075013799 substrate binding site [chemical binding]; other site 1207075013800 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1207075013801 RDD family; Region: RDD; pfam06271 1207075013802 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1207075013803 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1207075013804 PAS domain S-box; Region: sensory_box; TIGR00229 1207075013805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075013806 putative active site [active] 1207075013807 heme pocket [chemical binding]; other site 1207075013808 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075013809 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075013810 metal binding site [ion binding]; metal-binding site 1207075013811 active site 1207075013812 I-site; other site 1207075013813 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075013814 MoxR-like ATPases [General function prediction only]; Region: COG0714 1207075013815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075013816 Walker A motif; other site 1207075013817 ATP binding site [chemical binding]; other site 1207075013818 Walker B motif; other site 1207075013819 arginine finger; other site 1207075013820 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1207075013821 Protein of unknown function DUF58; Region: DUF58; pfam01882 1207075013822 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1207075013823 metal ion-dependent adhesion site (MIDAS); other site 1207075013824 PilZ domain; Region: PilZ; pfam07238 1207075013825 pyruvate kinase; Provisional; Region: PRK05826 1207075013826 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1207075013827 domain interfaces; other site 1207075013828 active site 1207075013829 enoyl-CoA hydratase; Provisional; Region: PRK06688 1207075013830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1207075013831 substrate binding site [chemical binding]; other site 1207075013832 oxyanion hole (OAH) forming residues; other site 1207075013833 trimer interface [polypeptide binding]; other site 1207075013834 hypothetical protein; Provisional; Region: PRK05713 1207075013835 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075013836 catalytic loop [active] 1207075013837 iron binding site [ion binding]; other site 1207075013838 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1207075013839 FAD binding pocket [chemical binding]; other site 1207075013840 FAD binding motif [chemical binding]; other site 1207075013841 phosphate binding motif [ion binding]; other site 1207075013842 beta-alpha-beta structure motif; other site 1207075013843 NAD binding pocket [chemical binding]; other site 1207075013844 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075013845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075013846 metal binding site [ion binding]; metal-binding site 1207075013847 active site 1207075013848 I-site; other site 1207075013849 putative fumarate hydratase; Provisional; Region: PRK15392 1207075013850 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1207075013851 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1207075013852 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1207075013853 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1207075013854 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1207075013855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075013856 dimer interface [polypeptide binding]; other site 1207075013857 phosphorylation site [posttranslational modification] 1207075013858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013859 ATP binding site [chemical binding]; other site 1207075013860 Mg2+ binding site [ion binding]; other site 1207075013861 G-X-G motif; other site 1207075013862 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075013863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013864 active site 1207075013865 phosphorylation site [posttranslational modification] 1207075013866 intermolecular recognition site; other site 1207075013867 dimerization interface [polypeptide binding]; other site 1207075013868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075013869 Walker A motif; other site 1207075013870 ATP binding site [chemical binding]; other site 1207075013871 Walker B motif; other site 1207075013872 arginine finger; other site 1207075013873 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1207075013874 Transposase; Region: HTH_Tnp_1; pfam01527 1207075013875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1207075013876 putative transposase OrfB; Reviewed; Region: PHA02517 1207075013877 HTH-like domain; Region: HTH_21; pfam13276 1207075013878 Integrase core domain; Region: rve; pfam00665 1207075013879 Integrase core domain; Region: rve_3; pfam13683 1207075013880 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1207075013881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075013882 putative substrate translocation pore; other site 1207075013883 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1207075013884 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1207075013885 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1207075013886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075013887 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075013888 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075013889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075013890 Walker A/P-loop; other site 1207075013891 ATP binding site [chemical binding]; other site 1207075013892 Q-loop/lid; other site 1207075013893 ABC transporter signature motif; other site 1207075013894 Walker B; other site 1207075013895 D-loop; other site 1207075013896 H-loop/switch region; other site 1207075013897 TOBE domain; Region: TOBE_2; pfam08402 1207075013898 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075013899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075013900 dimer interface [polypeptide binding]; other site 1207075013901 conserved gate region; other site 1207075013902 putative PBP binding loops; other site 1207075013903 ABC-ATPase subunit interface; other site 1207075013904 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1207075013905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075013906 dimer interface [polypeptide binding]; other site 1207075013907 putative PBP binding loops; other site 1207075013908 ABC-ATPase subunit interface; other site 1207075013909 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075013910 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075013911 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1207075013912 NAD(P) binding site [chemical binding]; other site 1207075013913 catalytic residues [active] 1207075013914 catalytic residues [active] 1207075013915 hypothetical protein; Provisional; Region: PRK07524 1207075013916 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1207075013917 PYR/PP interface [polypeptide binding]; other site 1207075013918 dimer interface [polypeptide binding]; other site 1207075013919 TPP binding site [chemical binding]; other site 1207075013920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1207075013921 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1207075013922 TPP-binding site [chemical binding]; other site 1207075013923 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075013924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075013925 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075013926 substrate binding pocket [chemical binding]; other site 1207075013927 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1207075013928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075013929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075013930 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075013931 putative effector binding pocket; other site 1207075013932 dimerization interface [polypeptide binding]; other site 1207075013933 Cupin domain; Region: Cupin_2; cl17218 1207075013934 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075013935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075013936 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1207075013937 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1207075013938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075013939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075013940 putative substrate translocation pore; other site 1207075013941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075013942 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1207075013943 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1207075013944 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075013945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075013946 NAD(P) binding site [chemical binding]; other site 1207075013947 active site 1207075013948 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1207075013949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075013950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1207075013951 dimerization interface [polypeptide binding]; other site 1207075013952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1207075013953 ACT domain; Region: ACT_3; pfam10000 1207075013954 Family description; Region: ACT_7; pfam13840 1207075013955 Lysine efflux permease [General function prediction only]; Region: COG1279 1207075013956 superoxide dismutase; Provisional; Region: PRK10543 1207075013957 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1207075013958 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1207075013959 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1207075013960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075013961 metal binding site [ion binding]; metal-binding site 1207075013962 active site 1207075013963 I-site; other site 1207075013964 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075013965 Imelysin; Region: Peptidase_M75; cl09159 1207075013966 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1207075013967 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1207075013968 Imelysin; Region: Peptidase_M75; cl09159 1207075013969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1207075013970 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075013971 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075013972 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075013973 multidrug efflux protein; Reviewed; Region: PRK09579 1207075013974 Protein export membrane protein; Region: SecD_SecF; cl14618 1207075013975 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1207075013976 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1207075013977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075013978 S-adenosylmethionine binding site [chemical binding]; other site 1207075013979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075013980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075013981 dimer interface [polypeptide binding]; other site 1207075013982 phosphorylation site [posttranslational modification] 1207075013983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075013984 ATP binding site [chemical binding]; other site 1207075013985 Mg2+ binding site [ion binding]; other site 1207075013986 G-X-G motif; other site 1207075013987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1207075013988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075013989 active site 1207075013990 phosphorylation site [posttranslational modification] 1207075013991 intermolecular recognition site; other site 1207075013992 dimerization interface [polypeptide binding]; other site 1207075013993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075013994 DNA binding site [nucleotide binding] 1207075013995 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1207075013996 active site 1207075013997 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1207075013998 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1207075013999 ring oligomerisation interface [polypeptide binding]; other site 1207075014000 ATP/Mg binding site [chemical binding]; other site 1207075014001 stacking interactions; other site 1207075014002 hinge regions; other site 1207075014003 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1207075014004 oligomerisation interface [polypeptide binding]; other site 1207075014005 mobile loop; other site 1207075014006 roof hairpin; other site 1207075014007 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1207075014008 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1207075014009 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1207075014010 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1207075014011 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1207075014012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075014013 NAD(P) binding site [chemical binding]; other site 1207075014014 active site 1207075014015 antiporter inner membrane protein; Provisional; Region: PRK11670 1207075014016 Domain of unknown function DUF59; Region: DUF59; pfam01883 1207075014017 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1207075014018 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1207075014019 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1207075014020 active site 1207075014021 HIGH motif; other site 1207075014022 KMSKS motif; other site 1207075014023 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1207075014024 tRNA binding surface [nucleotide binding]; other site 1207075014025 anticodon binding site; other site 1207075014026 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1207075014027 dimer interface [polypeptide binding]; other site 1207075014028 putative tRNA-binding site [nucleotide binding]; other site 1207075014029 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1207075014030 ferredoxin; Provisional; Region: PRK08764 1207075014031 Putative Fe-S cluster; Region: FeS; pfam04060 1207075014032 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1207075014033 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1207075014034 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 1207075014035 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1207075014036 endonuclease III; Provisional; Region: PRK10702 1207075014037 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1207075014038 minor groove reading motif; other site 1207075014039 helix-hairpin-helix signature motif; other site 1207075014040 substrate binding pocket [chemical binding]; other site 1207075014041 active site 1207075014042 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1207075014043 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075014044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075014045 active site 1207075014046 phosphorylation site [posttranslational modification] 1207075014047 intermolecular recognition site; other site 1207075014048 dimerization interface [polypeptide binding]; other site 1207075014049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075014050 DNA binding residues [nucleotide binding] 1207075014051 dimerization interface [polypeptide binding]; other site 1207075014052 argininosuccinate synthase; Provisional; Region: PRK13820 1207075014053 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1207075014054 ANP binding site [chemical binding]; other site 1207075014055 Substrate Binding Site II [chemical binding]; other site 1207075014056 Substrate Binding Site I [chemical binding]; other site 1207075014057 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075014058 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075014059 ligand binding site [chemical binding]; other site 1207075014060 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1207075014061 active site 1207075014062 substrate binding pocket [chemical binding]; other site 1207075014063 dimer interface [polypeptide binding]; other site 1207075014064 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1207075014065 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1207075014066 dimer interface [polypeptide binding]; other site 1207075014067 catalytic site [active] 1207075014068 putative active site [active] 1207075014069 putative substrate binding site [chemical binding]; other site 1207075014070 peroxidase; Provisional; Region: PRK15000 1207075014071 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1207075014072 dimer interface [polypeptide binding]; other site 1207075014073 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1207075014074 catalytic triad [active] 1207075014075 peroxidatic and resolving cysteines [active] 1207075014076 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1207075014077 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1207075014078 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1207075014079 heme binding site [chemical binding]; other site 1207075014080 ferroxidase pore; other site 1207075014081 ferroxidase diiron center [ion binding]; other site 1207075014082 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1207075014083 putative GSH binding site [chemical binding]; other site 1207075014084 catalytic residues [active] 1207075014085 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1207075014086 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1207075014087 putative [Fe4-S4] binding site [ion binding]; other site 1207075014088 putative molybdopterin cofactor binding site [chemical binding]; other site 1207075014089 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1207075014090 putative molybdopterin cofactor binding site; other site 1207075014091 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1207075014092 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1207075014093 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1207075014094 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075014095 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1207075014096 Walker A/P-loop; other site 1207075014097 ATP binding site [chemical binding]; other site 1207075014098 Q-loop/lid; other site 1207075014099 ABC transporter signature motif; other site 1207075014100 Walker B; other site 1207075014101 D-loop; other site 1207075014102 H-loop/switch region; other site 1207075014103 TOBE domain; Region: TOBE_2; pfam08402 1207075014104 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1207075014105 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1207075014106 putative deacylase active site [active] 1207075014107 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1207075014108 amphipathic channel; other site 1207075014109 Asn-Pro-Ala signature motifs; other site 1207075014110 glycerol kinase; Provisional; Region: glpK; PRK00047 1207075014111 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1207075014112 N- and C-terminal domain interface [polypeptide binding]; other site 1207075014113 active site 1207075014114 MgATP binding site [chemical binding]; other site 1207075014115 catalytic site [active] 1207075014116 metal binding site [ion binding]; metal-binding site 1207075014117 glycerol binding site [chemical binding]; other site 1207075014118 homotetramer interface [polypeptide binding]; other site 1207075014119 homodimer interface [polypeptide binding]; other site 1207075014120 protein IIAGlc interface [polypeptide binding]; other site 1207075014121 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1207075014122 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1207075014123 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1207075014124 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1207075014125 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1207075014126 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1207075014127 active site 1207075014128 FMN binding site [chemical binding]; other site 1207075014129 substrate binding site [chemical binding]; other site 1207075014130 homotetramer interface [polypeptide binding]; other site 1207075014131 catalytic residue [active] 1207075014132 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1207075014133 DHH family; Region: DHH; pfam01368 1207075014134 DHHA1 domain; Region: DHHA1; pfam02272 1207075014135 YaeQ protein; Region: YaeQ; pfam07152 1207075014136 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1207075014137 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1207075014138 conserved hypothetical protein; Region: TIGR02285 1207075014139 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1207075014140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075014141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075014142 substrate binding pocket [chemical binding]; other site 1207075014143 membrane-bound complex binding site; other site 1207075014144 hinge residues; other site 1207075014145 PAS fold; Region: PAS; pfam00989 1207075014146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014147 putative active site [active] 1207075014148 heme pocket [chemical binding]; other site 1207075014149 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1207075014150 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1207075014151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075014152 catalytic residue [active] 1207075014153 homoserine dehydrogenase; Provisional; Region: PRK06349 1207075014154 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1207075014155 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1207075014156 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1207075014157 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1207075014158 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1207075014159 dimerization domain [polypeptide binding]; other site 1207075014160 dimer interface [polypeptide binding]; other site 1207075014161 catalytic residues [active] 1207075014162 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1207075014163 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1207075014164 active site 1207075014165 Int/Topo IB signature motif; other site 1207075014166 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1207075014167 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1207075014168 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1207075014169 RimM N-terminal domain; Region: RimM; pfam01782 1207075014170 PRC-barrel domain; Region: PRC; pfam05239 1207075014171 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1207075014172 signal recognition particle protein; Provisional; Region: PRK10867 1207075014173 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1207075014174 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1207075014175 P loop; other site 1207075014176 GTP binding site [chemical binding]; other site 1207075014177 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1207075014178 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1207075014179 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1207075014180 Domain of unknown function DUF21; Region: DUF21; pfam01595 1207075014181 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1207075014182 Transporter associated domain; Region: CorC_HlyC; smart01091 1207075014183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075014184 metabolite-proton symporter; Region: 2A0106; TIGR00883 1207075014185 putative substrate translocation pore; other site 1207075014186 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1207075014187 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1207075014188 HIGH motif; other site 1207075014189 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1207075014190 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1207075014191 active site 1207075014192 KMSKS motif; other site 1207075014193 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1207075014194 tRNA binding surface [nucleotide binding]; other site 1207075014195 anticodon binding site; other site 1207075014196 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1207075014197 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1207075014198 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1207075014199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075014200 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075014201 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075014202 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1207075014203 IHF - DNA interface [nucleotide binding]; other site 1207075014204 IHF dimer interface [polypeptide binding]; other site 1207075014205 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1207075014206 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1207075014207 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1207075014208 catalytic residues [active] 1207075014209 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075014210 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1207075014211 C-terminal domain interface [polypeptide binding]; other site 1207075014212 GSH binding site (G-site) [chemical binding]; other site 1207075014213 dimer interface [polypeptide binding]; other site 1207075014214 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1207075014215 N-terminal domain interface [polypeptide binding]; other site 1207075014216 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1207075014217 GIY-YIG motif/motif A; other site 1207075014218 putative active site [active] 1207075014219 putative metal binding site [ion binding]; other site 1207075014220 SnoaL-like domain; Region: SnoaL_3; pfam13474 1207075014221 SnoaL-like domain; Region: SnoaL_2; pfam12680 1207075014222 transcriptional regulator RcsB; Provisional; Region: PRK10840 1207075014223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075014224 active site 1207075014225 phosphorylation site [posttranslational modification] 1207075014226 intermolecular recognition site; other site 1207075014227 dimerization interface [polypeptide binding]; other site 1207075014228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075014229 DNA binding residues [nucleotide binding] 1207075014230 dimerization interface [polypeptide binding]; other site 1207075014231 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1207075014232 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1207075014233 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1207075014234 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1207075014235 PapC N-terminal domain; Region: PapC_N; pfam13954 1207075014236 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1207075014237 PapC C-terminal domain; Region: PapC_C; pfam13953 1207075014238 hypothetical protein; Provisional; Region: PRK15301 1207075014239 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1207075014240 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1207075014241 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1207075014242 cyanate transporter; Region: CynX; TIGR00896 1207075014243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075014244 putative substrate translocation pore; other site 1207075014245 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075014246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075014247 DNA-binding site [nucleotide binding]; DNA binding site 1207075014248 FCD domain; Region: FCD; pfam07729 1207075014249 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1207075014250 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075014251 Walker A/P-loop; other site 1207075014252 ATP binding site [chemical binding]; other site 1207075014253 Q-loop/lid; other site 1207075014254 ABC transporter signature motif; other site 1207075014255 Walker B; other site 1207075014256 D-loop; other site 1207075014257 H-loop/switch region; other site 1207075014258 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075014259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075014260 dimer interface [polypeptide binding]; other site 1207075014261 conserved gate region; other site 1207075014262 putative PBP binding loops; other site 1207075014263 ABC-ATPase subunit interface; other site 1207075014264 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1207075014265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075014266 conserved gate region; other site 1207075014267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075014268 dimer interface [polypeptide binding]; other site 1207075014269 ABC-ATPase subunit interface; other site 1207075014270 putative PBP binding loops; other site 1207075014271 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075014272 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075014273 substrate binding pocket [chemical binding]; other site 1207075014274 membrane-bound complex binding site; other site 1207075014275 hinge residues; other site 1207075014276 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1207075014277 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1207075014278 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1207075014279 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1207075014280 ATP binding site [chemical binding]; other site 1207075014281 Mg++ binding site [ion binding]; other site 1207075014282 motif III; other site 1207075014283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075014284 nucleotide binding region [chemical binding]; other site 1207075014285 ATP-binding site [chemical binding]; other site 1207075014286 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1207075014287 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1207075014288 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075014289 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1207075014290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1207075014291 YheO-like PAS domain; Region: PAS_6; pfam08348 1207075014292 HTH domain; Region: HTH_22; pfam13309 1207075014293 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1207075014294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075014295 substrate binding pocket [chemical binding]; other site 1207075014296 membrane-bound complex binding site; other site 1207075014297 hinge residues; other site 1207075014298 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1207075014299 MoaE homodimer interface [polypeptide binding]; other site 1207075014300 MoaD interaction [polypeptide binding]; other site 1207075014301 active site residues [active] 1207075014302 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1207075014303 MoaE interaction surface [polypeptide binding]; other site 1207075014304 MoeB interaction surface [polypeptide binding]; other site 1207075014305 thiocarboxylated glycine; other site 1207075014306 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1207075014307 trimer interface [polypeptide binding]; other site 1207075014308 dimer interface [polypeptide binding]; other site 1207075014309 putative active site [active] 1207075014310 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1207075014311 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1207075014312 putative active site [active] 1207075014313 PhoH-like protein; Region: PhoH; pfam02562 1207075014314 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1207075014315 NodB motif; other site 1207075014316 active site 1207075014317 catalytic site [active] 1207075014318 hypothetical protein; Validated; Region: PRK02101 1207075014319 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1207075014320 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1207075014321 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1207075014322 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1207075014323 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1207075014324 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1207075014325 PilZ domain; Region: PilZ; pfam07238 1207075014326 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075014327 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1207075014328 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1207075014329 Right handed beta helix region; Region: Beta_helix; pfam13229 1207075014330 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1207075014331 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1207075014332 active site 1207075014333 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1207075014334 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1207075014335 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1207075014336 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1207075014337 Substrate binding site; other site 1207075014338 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1207075014339 short chain dehydrogenase; Provisional; Region: PRK05693 1207075014340 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1207075014341 NADP binding site [chemical binding]; other site 1207075014342 active site 1207075014343 steroid binding site; other site 1207075014344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1207075014345 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1207075014346 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075014347 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075014348 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1207075014349 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1207075014350 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1207075014351 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1207075014352 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1207075014353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075014354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075014355 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075014356 putative effector binding pocket; other site 1207075014357 dimerization interface [polypeptide binding]; other site 1207075014358 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1207075014359 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075014360 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075014361 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1207075014362 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1207075014363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075014364 active site 1207075014365 phosphorylation site [posttranslational modification] 1207075014366 intermolecular recognition site; other site 1207075014367 dimerization interface [polypeptide binding]; other site 1207075014368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075014369 DNA binding site [nucleotide binding] 1207075014370 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1207075014371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075014372 dimer interface [polypeptide binding]; other site 1207075014373 phosphorylation site [posttranslational modification] 1207075014374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075014375 ATP binding site [chemical binding]; other site 1207075014376 G-X-G motif; other site 1207075014377 Cache domain; Region: Cache_1; pfam02743 1207075014378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075014379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075014380 metal binding site [ion binding]; metal-binding site 1207075014381 active site 1207075014382 I-site; other site 1207075014383 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1207075014384 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1207075014385 cell division protein FtsZ; Validated; Region: PRK09330 1207075014386 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1207075014387 nucleotide binding site [chemical binding]; other site 1207075014388 SulA interaction site; other site 1207075014389 cell division protein FtsA; Region: ftsA; TIGR01174 1207075014390 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1207075014391 nucleotide binding site [chemical binding]; other site 1207075014392 Cell division protein FtsA; Region: FtsA; pfam14450 1207075014393 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1207075014394 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1207075014395 Cell division protein FtsQ; Region: FtsQ; pfam03799 1207075014396 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1207075014397 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1207075014398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1207075014399 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1207075014400 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1207075014401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1207075014402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1207075014403 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1207075014404 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1207075014405 active site 1207075014406 homodimer interface [polypeptide binding]; other site 1207075014407 cell division protein FtsW; Region: ftsW; TIGR02614 1207075014408 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1207075014409 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1207075014410 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1207075014411 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1207075014412 Mg++ binding site [ion binding]; other site 1207075014413 putative catalytic motif [active] 1207075014414 putative substrate binding site [chemical binding]; other site 1207075014415 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1207075014416 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1207075014417 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1207075014418 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1207075014419 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1207075014420 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1207075014421 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1207075014422 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1207075014423 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1207075014424 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1207075014425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1207075014426 Cell division protein FtsL; Region: FtsL; pfam04999 1207075014427 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1207075014428 MraW methylase family; Region: Methyltransf_5; cl17771 1207075014429 cell division protein MraZ; Reviewed; Region: PRK00326 1207075014430 MraZ protein; Region: MraZ; pfam02381 1207075014431 MraZ protein; Region: MraZ; pfam02381 1207075014432 Predicted methyltransferases [General function prediction only]; Region: COG0313 1207075014433 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1207075014434 putative SAM binding site [chemical binding]; other site 1207075014435 putative homodimer interface [polypeptide binding]; other site 1207075014436 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1207075014437 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1207075014438 putative ligand binding site [chemical binding]; other site 1207075014439 hypothetical protein; Reviewed; Region: PRK12497 1207075014440 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1207075014441 dimer interface [polypeptide binding]; other site 1207075014442 active site 1207075014443 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1207075014444 BON domain; Region: BON; pfam04972 1207075014445 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1207075014446 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1207075014447 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1207075014448 C-terminal domain interface [polypeptide binding]; other site 1207075014449 putative GSH binding site (G-site) [chemical binding]; other site 1207075014450 dimer interface [polypeptide binding]; other site 1207075014451 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1207075014452 dimer interface [polypeptide binding]; other site 1207075014453 N-terminal domain interface [polypeptide binding]; other site 1207075014454 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1207075014455 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1207075014456 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1207075014457 Qi binding site; other site 1207075014458 intrachain domain interface; other site 1207075014459 interchain domain interface [polypeptide binding]; other site 1207075014460 heme bH binding site [chemical binding]; other site 1207075014461 heme bL binding site [chemical binding]; other site 1207075014462 Qo binding site; other site 1207075014463 interchain domain interface [polypeptide binding]; other site 1207075014464 intrachain domain interface; other site 1207075014465 Qi binding site; other site 1207075014466 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1207075014467 Qo binding site; other site 1207075014468 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1207075014469 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1207075014470 [2Fe-2S] cluster binding site [ion binding]; other site 1207075014471 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1207075014472 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1207075014473 23S rRNA interface [nucleotide binding]; other site 1207075014474 L3 interface [polypeptide binding]; other site 1207075014475 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1207075014476 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1207075014477 active site 1207075014478 catalytic tetrad [active] 1207075014479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1207075014480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075014481 active site 1207075014482 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075014483 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1207075014484 conserved cys residue [active] 1207075014485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075014486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075014487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075014488 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1207075014489 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075014490 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 1207075014491 putative active site [active] 1207075014492 catalytic triad [active] 1207075014493 putative dimer interface [polypeptide binding]; other site 1207075014494 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1207075014495 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1207075014496 active site 1207075014497 homotetramer interface [polypeptide binding]; other site 1207075014498 homodimer interface [polypeptide binding]; other site 1207075014499 Predicted ATPase [General function prediction only]; Region: COG1485 1207075014500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1207075014501 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1207075014502 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1207075014503 active site 1207075014504 HIGH motif; other site 1207075014505 dimer interface [polypeptide binding]; other site 1207075014506 KMSKS motif; other site 1207075014507 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1207075014508 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1207075014509 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1207075014510 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1207075014511 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1207075014512 ligand binding site [chemical binding]; other site 1207075014513 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1207075014514 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1207075014515 AAA ATPase domain; Region: AAA_16; pfam13191 1207075014516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075014517 DNA binding residues [nucleotide binding] 1207075014518 dimerization interface [polypeptide binding]; other site 1207075014519 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1207075014520 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1207075014521 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1207075014522 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1207075014523 acyl-activating enzyme (AAE) consensus motif; other site 1207075014524 AMP binding site [chemical binding]; other site 1207075014525 active site 1207075014526 CoA binding site [chemical binding]; other site 1207075014527 LysE type translocator; Region: LysE; cl00565 1207075014528 glycerate dehydrogenase; Provisional; Region: PRK06487 1207075014529 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1207075014530 putative ligand binding site [chemical binding]; other site 1207075014531 putative NAD binding site [chemical binding]; other site 1207075014532 catalytic site [active] 1207075014533 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1207075014534 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1207075014535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075014536 S-adenosylmethionine binding site [chemical binding]; other site 1207075014537 Predicted membrane protein [Function unknown]; Region: COG2119 1207075014538 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1207075014539 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1207075014540 Peptidase family M48; Region: Peptidase_M48; pfam01435 1207075014541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1207075014542 dimerization interface [polypeptide binding]; other site 1207075014543 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075014544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075014545 dimer interface [polypeptide binding]; other site 1207075014546 putative CheW interface [polypeptide binding]; other site 1207075014547 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1207075014548 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1207075014549 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1207075014550 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1207075014551 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075014552 putative acyl-acceptor binding pocket; other site 1207075014553 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1207075014554 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1207075014555 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1207075014556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075014557 active site 1207075014558 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075014559 active site 1207075014560 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1207075014561 ferrochelatase; Reviewed; Region: hemH; PRK00035 1207075014562 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1207075014563 C-terminal domain interface [polypeptide binding]; other site 1207075014564 active site 1207075014565 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1207075014566 active site 1207075014567 N-terminal domain interface [polypeptide binding]; other site 1207075014568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075014569 TIGR01777 family protein; Region: yfcH 1207075014570 NAD(P) binding site [chemical binding]; other site 1207075014571 active site 1207075014572 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1207075014573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075014574 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1207075014575 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1207075014576 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1207075014577 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1207075014578 DNA binding residues [nucleotide binding] 1207075014579 transcriptional regulator MirA; Provisional; Region: PRK15043 1207075014580 B12 binding domain; Region: B12-binding_2; pfam02607 1207075014581 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1207075014582 DNA photolyase; Region: DNA_photolyase; pfam00875 1207075014583 short chain dehydrogenase; Provisional; Region: PRK06101 1207075014584 classical (c) SDRs; Region: SDR_c; cd05233 1207075014585 NAD(P) binding site [chemical binding]; other site 1207075014586 active site 1207075014587 Flagellin N-methylase; Region: FliB; pfam03692 1207075014588 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1207075014589 glutamate racemase; Provisional; Region: PRK00865 1207075014590 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1207075014591 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1207075014592 ATP binding site [chemical binding]; other site 1207075014593 substrate interface [chemical binding]; other site 1207075014594 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1207075014595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075014596 S-adenosylmethionine binding site [chemical binding]; other site 1207075014597 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1207075014598 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1207075014599 RF-1 domain; Region: RF-1; pfam00472 1207075014600 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1207075014601 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1207075014602 tRNA; other site 1207075014603 putative tRNA binding site [nucleotide binding]; other site 1207075014604 putative NADP binding site [chemical binding]; other site 1207075014605 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1207075014606 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1207075014607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075014608 binding surface 1207075014609 TPR motif; other site 1207075014610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075014611 binding surface 1207075014612 TPR motif; other site 1207075014613 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1207075014614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075014615 binding surface 1207075014616 TPR motif; other site 1207075014617 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1207075014618 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1207075014619 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1207075014620 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1207075014621 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1207075014622 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1207075014623 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1207075014624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075014625 active site 1207075014626 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1207075014627 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1207075014628 5S rRNA interface [nucleotide binding]; other site 1207075014629 CTC domain interface [polypeptide binding]; other site 1207075014630 L16 interface [polypeptide binding]; other site 1207075014631 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1207075014632 putative active site [active] 1207075014633 catalytic residue [active] 1207075014634 GTP-binding protein YchF; Reviewed; Region: PRK09601 1207075014635 YchF GTPase; Region: YchF; cd01900 1207075014636 G1 box; other site 1207075014637 GTP/Mg2+ binding site [chemical binding]; other site 1207075014638 Switch I region; other site 1207075014639 G2 box; other site 1207075014640 Switch II region; other site 1207075014641 G3 box; other site 1207075014642 G4 box; other site 1207075014643 G5 box; other site 1207075014644 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1207075014645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075014646 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075014647 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075014648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075014649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075014650 putative substrate translocation pore; other site 1207075014651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075014652 dimer interface [polypeptide binding]; other site 1207075014653 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1207075014654 putative CheW interface [polypeptide binding]; other site 1207075014655 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 1207075014656 putative active site [active] 1207075014657 Zn binding site [ion binding]; other site 1207075014658 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1207075014659 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1207075014660 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1207075014661 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1207075014662 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1207075014663 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1207075014664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014665 PAS domain; Region: PAS_9; pfam13426 1207075014666 putative active site [active] 1207075014667 heme pocket [chemical binding]; other site 1207075014668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014669 PAS domain; Region: PAS_9; pfam13426 1207075014670 putative active site [active] 1207075014671 heme pocket [chemical binding]; other site 1207075014672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075014673 dimer interface [polypeptide binding]; other site 1207075014674 putative CheW interface [polypeptide binding]; other site 1207075014675 metabolite-proton symporter; Region: 2A0106; TIGR00883 1207075014676 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1207075014677 SET domain; Region: SET; pfam00856 1207075014678 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1207075014679 active site clefts [active] 1207075014680 zinc binding site [ion binding]; other site 1207075014681 dimer interface [polypeptide binding]; other site 1207075014682 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1207075014683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075014684 Coenzyme A binding pocket [chemical binding]; other site 1207075014685 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1207075014686 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1207075014687 mce related protein; Region: MCE; pfam02470 1207075014688 mce related protein; Region: MCE; pfam02470 1207075014689 mce related protein; Region: MCE; pfam02470 1207075014690 mce related protein; Region: MCE; pfam02470 1207075014691 mce related protein; Region: MCE; pfam02470 1207075014692 mce related protein; Region: MCE; pfam02470 1207075014693 Paraquat-inducible protein A; Region: PqiA; pfam04403 1207075014694 Paraquat-inducible protein A; Region: PqiA; pfam04403 1207075014695 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1207075014696 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1207075014697 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1207075014698 Moco binding site; other site 1207075014699 metal coordination site [ion binding]; other site 1207075014700 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1207075014701 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1207075014702 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1207075014703 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1207075014704 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1207075014705 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1207075014706 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1207075014707 putative valine binding site [chemical binding]; other site 1207075014708 dimer interface [polypeptide binding]; other site 1207075014709 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1207075014710 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1207075014711 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1207075014712 PYR/PP interface [polypeptide binding]; other site 1207075014713 dimer interface [polypeptide binding]; other site 1207075014714 TPP binding site [chemical binding]; other site 1207075014715 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1207075014716 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1207075014717 TPP-binding site [chemical binding]; other site 1207075014718 dimer interface [polypeptide binding]; other site 1207075014719 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1207075014720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1207075014721 TPR motif; other site 1207075014722 binding surface 1207075014723 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1207075014724 Transglycosylase; Region: Transgly; pfam00912 1207075014725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1207075014726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1207075014727 AAA domain; Region: AAA_33; pfam13671 1207075014728 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1207075014729 ATP-binding site [chemical binding]; other site 1207075014730 Gluconate-6-phosphate binding site [chemical binding]; other site 1207075014731 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1207075014732 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1207075014733 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1207075014734 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1207075014735 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1207075014736 iron-sulfur cluster [ion binding]; other site 1207075014737 [2Fe-2S] cluster binding site [ion binding]; other site 1207075014738 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1207075014739 hypothetical protein; Provisional; Region: PRK08960 1207075014740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075014741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075014742 homodimer interface [polypeptide binding]; other site 1207075014743 catalytic residue [active] 1207075014744 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1207075014745 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1207075014746 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1207075014747 active site 1207075014748 HIGH motif; other site 1207075014749 nucleotide binding site [chemical binding]; other site 1207075014750 KMSKS motif; other site 1207075014751 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1207075014752 Na binding site [ion binding]; other site 1207075014753 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1207075014754 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014755 putative active site [active] 1207075014756 heme pocket [chemical binding]; other site 1207075014757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075014758 dimer interface [polypeptide binding]; other site 1207075014759 phosphorylation site [posttranslational modification] 1207075014760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075014761 ATP binding site [chemical binding]; other site 1207075014762 Mg2+ binding site [ion binding]; other site 1207075014763 G-X-G motif; other site 1207075014764 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075014765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075014766 active site 1207075014767 phosphorylation site [posttranslational modification] 1207075014768 intermolecular recognition site; other site 1207075014769 dimerization interface [polypeptide binding]; other site 1207075014770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075014771 Walker A motif; other site 1207075014772 ATP binding site [chemical binding]; other site 1207075014773 Walker B motif; other site 1207075014774 arginine finger; other site 1207075014775 poly(A) polymerase; Region: pcnB; TIGR01942 1207075014776 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1207075014777 active site 1207075014778 NTP binding site [chemical binding]; other site 1207075014779 metal binding triad [ion binding]; metal-binding site 1207075014780 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1207075014781 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1207075014782 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1207075014783 catalytic center binding site [active] 1207075014784 ATP binding site [chemical binding]; other site 1207075014785 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1207075014786 oligomerization interface [polypeptide binding]; other site 1207075014787 active site 1207075014788 metal binding site [ion binding]; metal-binding site 1207075014789 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1207075014790 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1207075014791 active site 1207075014792 ATP-binding site [chemical binding]; other site 1207075014793 pantoate-binding site; other site 1207075014794 HXXH motif; other site 1207075014795 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1207075014796 tetramerization interface [polypeptide binding]; other site 1207075014797 active site 1207075014798 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1207075014799 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1207075014800 active site 1207075014801 dimer interface [polypeptide binding]; other site 1207075014802 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1207075014803 dimer interface [polypeptide binding]; other site 1207075014804 active site 1207075014805 acetyl-CoA synthetase; Provisional; Region: PRK00174 1207075014806 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1207075014807 active site 1207075014808 CoA binding site [chemical binding]; other site 1207075014809 acyl-activating enzyme (AAE) consensus motif; other site 1207075014810 AMP binding site [chemical binding]; other site 1207075014811 acetate binding site [chemical binding]; other site 1207075014812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1207075014813 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1207075014814 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1207075014815 putative RNA binding site [nucleotide binding]; other site 1207075014816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075014817 S-adenosylmethionine binding site [chemical binding]; other site 1207075014818 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1207075014819 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1207075014820 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1207075014821 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1207075014822 BON domain; Region: BON; pfam04972 1207075014823 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1207075014824 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1207075014825 Pilin (bacterial filament); Region: Pilin; pfam00114 1207075014826 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1207075014827 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1207075014828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1207075014829 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1207075014830 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1207075014831 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1207075014832 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1207075014833 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1207075014834 CoA-binding site [chemical binding]; other site 1207075014835 ATP-binding [chemical binding]; other site 1207075014836 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1207075014837 Predicted membrane protein [Function unknown]; Region: COG3235 1207075014838 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1207075014839 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1207075014840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1207075014841 MOSC domain; Region: MOSC; pfam03473 1207075014842 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1207075014843 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1207075014844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075014845 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1207075014846 Clp amino terminal domain; Region: Clp_N; pfam02861 1207075014847 Clp amino terminal domain; Region: Clp_N; pfam02861 1207075014848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075014849 Walker A motif; other site 1207075014850 ATP binding site [chemical binding]; other site 1207075014851 Walker B motif; other site 1207075014852 arginine finger; other site 1207075014853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075014854 Walker A motif; other site 1207075014855 ATP binding site [chemical binding]; other site 1207075014856 Walker B motif; other site 1207075014857 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1207075014858 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1207075014859 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1207075014860 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1207075014861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075014862 RNA binding surface [nucleotide binding]; other site 1207075014863 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1207075014864 active site 1207075014865 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1207075014866 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; pfam09583 1207075014867 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1207075014868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075014869 active site 1207075014870 phosphorylation site [posttranslational modification] 1207075014871 intermolecular recognition site; other site 1207075014872 dimerization interface [polypeptide binding]; other site 1207075014873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075014874 Walker A motif; other site 1207075014875 ATP binding site [chemical binding]; other site 1207075014876 Walker B motif; other site 1207075014877 arginine finger; other site 1207075014878 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075014879 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1207075014880 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075014881 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1207075014882 PilX N-terminal; Region: PilX_N; pfam14341 1207075014883 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1207075014884 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1207075014885 Type II transport protein GspH; Region: GspH; pfam12019 1207075014886 hypothetical protein; Provisional; Region: PRK10506 1207075014887 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1207075014888 Type II transport protein GspH; Region: GspH; pfam12019 1207075014889 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1207075014890 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1207075014891 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1207075014892 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075014893 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1207075014894 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1207075014895 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1207075014896 active site 1207075014897 HIGH motif; other site 1207075014898 nucleotide binding site [chemical binding]; other site 1207075014899 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1207075014900 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1207075014901 active site 1207075014902 KMSKS motif; other site 1207075014903 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1207075014904 tRNA binding surface [nucleotide binding]; other site 1207075014905 anticodon binding site; other site 1207075014906 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1207075014907 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1207075014908 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1207075014909 active site 1207075014910 Riboflavin kinase; Region: Flavokinase; smart00904 1207075014911 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1207075014912 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1207075014913 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1207075014914 CreA protein; Region: CreA; pfam05981 1207075014915 gamma-glutamyl kinase; Provisional; Region: PRK05429 1207075014916 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1207075014917 nucleotide binding site [chemical binding]; other site 1207075014918 homotetrameric interface [polypeptide binding]; other site 1207075014919 putative phosphate binding site [ion binding]; other site 1207075014920 putative allosteric binding site; other site 1207075014921 PUA domain; Region: PUA; pfam01472 1207075014922 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1207075014923 GTP1/OBG; Region: GTP1_OBG; pfam01018 1207075014924 Obg GTPase; Region: Obg; cd01898 1207075014925 G1 box; other site 1207075014926 GTP/Mg2+ binding site [chemical binding]; other site 1207075014927 Switch I region; other site 1207075014928 G2 box; other site 1207075014929 G3 box; other site 1207075014930 Switch II region; other site 1207075014931 G4 box; other site 1207075014932 G5 box; other site 1207075014933 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1207075014934 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1207075014935 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1207075014936 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1207075014937 substrate binding pocket [chemical binding]; other site 1207075014938 chain length determination region; other site 1207075014939 substrate-Mg2+ binding site; other site 1207075014940 catalytic residues [active] 1207075014941 aspartate-rich region 1; other site 1207075014942 active site lid residues [active] 1207075014943 aspartate-rich region 2; other site 1207075014944 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1207075014945 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1207075014946 PhnA protein; Region: PhnA; pfam03831 1207075014947 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1207075014948 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1207075014949 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075014950 hypothetical protein; Provisional; Region: PRK05208 1207075014951 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1207075014952 AAA domain; Region: AAA_32; pfam13654 1207075014953 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1207075014954 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1207075014955 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1207075014956 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1207075014957 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1207075014958 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1207075014959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075014960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075014961 homodimer interface [polypeptide binding]; other site 1207075014962 catalytic residue [active] 1207075014963 AzlC protein; Region: AzlC; pfam03591 1207075014964 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1207075014965 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1207075014966 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1207075014967 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075014968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075014969 ABC transporter; Region: ABC_tran_2; pfam12848 1207075014970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075014971 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075014972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014973 putative active site [active] 1207075014974 heme pocket [chemical binding]; other site 1207075014975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014976 putative active site [active] 1207075014977 heme pocket [chemical binding]; other site 1207075014978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075014979 PAS domain; Region: PAS_9; pfam13426 1207075014980 putative active site [active] 1207075014981 heme pocket [chemical binding]; other site 1207075014982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075014983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075014984 metal binding site [ion binding]; metal-binding site 1207075014985 active site 1207075014986 I-site; other site 1207075014987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075014988 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1207075014989 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1207075014990 dimer interface [polypeptide binding]; other site 1207075014991 active site 1207075014992 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1207075014993 folate binding site [chemical binding]; other site 1207075014994 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1207075014995 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075014996 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075014997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075014998 DNA-binding site [nucleotide binding]; DNA binding site 1207075014999 FCD domain; Region: FCD; pfam07729 1207075015000 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1207075015001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1207075015002 DNA-binding site [nucleotide binding]; DNA binding site 1207075015003 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1207075015004 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1207075015005 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1207075015006 P-loop, Walker A motif; other site 1207075015007 Base recognition motif; other site 1207075015008 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1207075015009 Uncharacterized small protein [Function unknown]; Region: COG2879 1207075015010 carbon starvation protein A; Provisional; Region: PRK15015 1207075015011 Carbon starvation protein CstA; Region: CstA; pfam02554 1207075015012 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1207075015013 PilZ domain; Region: PilZ; pfam07238 1207075015014 DNA repair protein RadA; Provisional; Region: PRK11823 1207075015015 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1207075015016 Walker A motif/ATP binding site; other site 1207075015017 ATP binding site [chemical binding]; other site 1207075015018 Walker B motif; other site 1207075015019 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1207075015020 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1207075015021 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1207075015022 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1207075015023 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1207075015024 FAD binding pocket [chemical binding]; other site 1207075015025 FAD binding motif [chemical binding]; other site 1207075015026 phosphate binding motif [ion binding]; other site 1207075015027 beta-alpha-beta structure motif; other site 1207075015028 NAD binding pocket [chemical binding]; other site 1207075015029 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1207075015030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075015031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075015032 DNA binding residues [nucleotide binding] 1207075015033 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1207075015034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075015035 S-adenosylmethionine binding site [chemical binding]; other site 1207075015036 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1207075015037 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1207075015038 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1207075015039 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1207075015040 enterobactin exporter EntS; Provisional; Region: PRK10489 1207075015041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075015042 putative substrate translocation pore; other site 1207075015043 DJ-1 family protein; Region: not_thiJ; TIGR01383 1207075015044 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1207075015045 conserved cys residue [active] 1207075015046 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1207075015047 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1207075015048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075015049 S-adenosylmethionine binding site [chemical binding]; other site 1207075015050 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1207075015051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075015052 LysR family transcriptional regulator; Provisional; Region: PRK14997 1207075015053 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1207075015054 putative effector binding pocket; other site 1207075015055 dimerization interface [polypeptide binding]; other site 1207075015056 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1207075015057 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1207075015058 active site 1207075015059 trimer interface [polypeptide binding]; other site 1207075015060 dimer interface [polypeptide binding]; other site 1207075015061 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1207075015062 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1207075015063 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1207075015064 shikimate binding site; other site 1207075015065 NAD(P) binding site [chemical binding]; other site 1207075015066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075015067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075015068 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1207075015069 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1207075015070 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1207075015071 dimer interface [polypeptide binding]; other site 1207075015072 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1207075015073 active site 1207075015074 Fe binding site [ion binding]; other site 1207075015075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075015076 D-galactonate transporter; Region: 2A0114; TIGR00893 1207075015077 putative substrate translocation pore; other site 1207075015078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1207075015079 EamA-like transporter family; Region: EamA; pfam00892 1207075015080 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1207075015081 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1207075015082 Bacterial transcriptional regulator; Region: IclR; pfam01614 1207075015083 Predicted metalloprotease [General function prediction only]; Region: COG2321 1207075015084 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1207075015085 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1207075015086 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1207075015087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075015088 active site 1207075015089 motif I; other site 1207075015090 motif II; other site 1207075015091 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1207075015092 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1207075015093 active site 1207075015094 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1207075015095 catalytic triad [active] 1207075015096 dimer interface [polypeptide binding]; other site 1207075015097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1207075015098 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1207075015099 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1207075015100 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1207075015101 putative active site [active] 1207075015102 Zn binding site [ion binding]; other site 1207075015103 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1207075015104 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1207075015105 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1207075015106 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1207075015107 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1207075015108 ATP binding site [chemical binding]; other site 1207075015109 Mg++ binding site [ion binding]; other site 1207075015110 motif III; other site 1207075015111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075015112 nucleotide binding region [chemical binding]; other site 1207075015113 ATP-binding site [chemical binding]; other site 1207075015114 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1207075015115 EamA-like transporter family; Region: EamA; pfam00892 1207075015116 EamA-like transporter family; Region: EamA; pfam00892 1207075015117 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1207075015118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075015119 putative DNA binding site [nucleotide binding]; other site 1207075015120 putative Zn2+ binding site [ion binding]; other site 1207075015121 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075015122 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1207075015123 active site 1207075015124 catalytic site [active] 1207075015125 substrate binding site [chemical binding]; other site 1207075015126 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1207075015127 LabA_like proteins; Region: LabA; cd10911 1207075015128 putative metal binding site [ion binding]; other site 1207075015129 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1207075015130 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1207075015131 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1207075015132 putative catalytic site [active] 1207075015133 putative metal binding site [ion binding]; other site 1207075015134 putative phosphate binding site [ion binding]; other site 1207075015135 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1207075015136 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075015137 Walker A/P-loop; other site 1207075015138 ATP binding site [chemical binding]; other site 1207075015139 Q-loop/lid; other site 1207075015140 ABC transporter signature motif; other site 1207075015141 Walker B; other site 1207075015142 D-loop; other site 1207075015143 H-loop/switch region; other site 1207075015144 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1207075015145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075015146 dimer interface [polypeptide binding]; other site 1207075015147 conserved gate region; other site 1207075015148 putative PBP binding loops; other site 1207075015149 ABC-ATPase subunit interface; other site 1207075015150 NMT1/THI5 like; Region: NMT1; pfam09084 1207075015151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075015152 membrane-bound complex binding site; other site 1207075015153 hinge residues; other site 1207075015154 putative aminotransferase; Provisional; Region: PRK12403 1207075015155 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075015156 inhibitor-cofactor binding pocket; inhibition site 1207075015157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075015158 catalytic residue [active] 1207075015159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075015160 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1207075015161 NAD(P) binding site [chemical binding]; other site 1207075015162 catalytic residues [active] 1207075015163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075015164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075015165 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1207075015166 putative substrate binding pocket [chemical binding]; other site 1207075015167 dimerization interface [polypeptide binding]; other site 1207075015168 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1207075015169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075015170 ATP binding site [chemical binding]; other site 1207075015171 putative Mg++ binding site [ion binding]; other site 1207075015172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075015173 nucleotide binding region [chemical binding]; other site 1207075015174 ATP-binding site [chemical binding]; other site 1207075015175 Helicase associated domain (HA2); Region: HA2; pfam04408 1207075015176 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1207075015177 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1207075015178 Cation efflux family; Region: Cation_efflux; cl00316 1207075015179 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 1207075015180 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075015181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075015182 putative DNA binding site [nucleotide binding]; other site 1207075015183 putative Zn2+ binding site [ion binding]; other site 1207075015184 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075015185 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1207075015186 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1207075015187 pseudouridine synthase; Region: TIGR00093 1207075015188 active site 1207075015189 AMP nucleosidase; Provisional; Region: PRK08292 1207075015190 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1207075015191 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1207075015192 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1207075015193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075015194 active site 1207075015195 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1207075015196 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1207075015197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1207075015198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075015199 dimer interface [polypeptide binding]; other site 1207075015200 phosphorylation site [posttranslational modification] 1207075015201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075015202 ATP binding site [chemical binding]; other site 1207075015203 Mg2+ binding site [ion binding]; other site 1207075015204 G-X-G motif; other site 1207075015205 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075015206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075015207 active site 1207075015208 phosphorylation site [posttranslational modification] 1207075015209 intermolecular recognition site; other site 1207075015210 dimerization interface [polypeptide binding]; other site 1207075015211 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1207075015212 dimer interface [polypeptide binding]; other site 1207075015213 substrate binding site [chemical binding]; other site 1207075015214 ATP binding site [chemical binding]; other site 1207075015215 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1207075015216 thiamine phosphate binding site [chemical binding]; other site 1207075015217 active site 1207075015218 pyrophosphate binding site [ion binding]; other site 1207075015219 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1207075015220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075015221 inhibitor-cofactor binding pocket; inhibition site 1207075015222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075015223 catalytic residue [active] 1207075015224 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1207075015225 Sel1-like repeats; Region: SEL1; smart00671 1207075015226 Sel1-like repeats; Region: SEL1; smart00671 1207075015227 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1207075015228 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1207075015229 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1207075015230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075015231 FeS/SAM binding site; other site 1207075015232 TRAM domain; Region: TRAM; pfam01938 1207075015233 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1207075015234 PhoH-like protein; Region: PhoH; pfam02562 1207075015235 metal-binding heat shock protein; Provisional; Region: PRK00016 1207075015236 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1207075015237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1207075015238 Transporter associated domain; Region: CorC_HlyC; smart01091 1207075015239 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1207075015240 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1207075015241 putative active site [active] 1207075015242 catalytic triad [active] 1207075015243 putative dimer interface [polypeptide binding]; other site 1207075015244 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1207075015245 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1207075015246 putative active site [active] 1207075015247 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1207075015248 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1207075015249 HIGH motif; other site 1207075015250 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1207075015251 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1207075015252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1207075015253 active site 1207075015254 KMSKS motif; other site 1207075015255 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1207075015256 tRNA binding surface [nucleotide binding]; other site 1207075015257 Lipopolysaccharide-assembly; Region: LptE; cl01125 1207075015258 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1207075015259 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1207075015260 Domain of unknown function; Region: DUF331; cl01149 1207075015261 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1207075015262 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075015263 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075015264 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1207075015265 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1207075015266 dimer interface [polypeptide binding]; other site 1207075015267 catalytic triad [active] 1207075015268 lipoyl synthase; Provisional; Region: PRK05481 1207075015269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075015270 FeS/SAM binding site; other site 1207075015271 lipoate-protein ligase B; Provisional; Region: PRK14342 1207075015272 hypothetical protein; Provisional; Region: PRK00341 1207075015273 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1207075015274 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1207075015275 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1207075015276 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1207075015277 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1207075015278 Sporulation related domain; Region: SPOR; pfam05036 1207075015279 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1207075015280 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1207075015281 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1207075015282 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1207075015283 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1207075015284 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1207075015285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1207075015286 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1207075015287 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1207075015288 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1207075015289 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1207075015290 active site 1207075015291 (T/H)XGH motif; other site 1207075015292 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1207075015293 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1207075015294 putative catalytic cysteine [active] 1207075015295 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1207075015296 active site 1207075015297 DNA binding site [nucleotide binding] 1207075015298 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1207075015299 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1207075015300 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1207075015301 active site 1207075015302 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1207075015303 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1207075015304 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1207075015305 LrgA family; Region: LrgA; cl00608 1207075015306 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1207075015307 putative active site [active] 1207075015308 putative catalytic site [active] 1207075015309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1207075015310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1207075015311 Peptidase C13 family; Region: Peptidase_C13; cl02159 1207075015312 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1207075015313 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1207075015314 NAD binding site [chemical binding]; other site 1207075015315 active site 1207075015316 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1207075015317 aromatic acid decarboxylase; Validated; Region: PRK05920 1207075015318 Flavoprotein; Region: Flavoprotein; pfam02441 1207075015319 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1207075015320 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1207075015321 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1207075015322 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1207075015323 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1207075015324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1207075015325 Walker A motif; other site 1207075015326 ATP binding site [chemical binding]; other site 1207075015327 Walker B motif; other site 1207075015328 arginine finger; other site 1207075015329 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1207075015330 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1207075015331 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1207075015332 NAD(P) binding site [chemical binding]; other site 1207075015333 catalytic residues [active] 1207075015334 ethanolamine permease; Region: 2A0305; TIGR00908 1207075015335 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1207075015336 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1207075015337 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1207075015338 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075015339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075015340 Coenzyme A binding pocket [chemical binding]; other site 1207075015341 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1207075015342 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1207075015343 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1207075015344 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1207075015345 dimer interface [polypeptide binding]; other site 1207075015346 substrate binding site [chemical binding]; other site 1207075015347 metal binding sites [ion binding]; metal-binding site 1207075015348 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1207075015349 Predicted transcriptional regulator [Transcription]; Region: COG2932 1207075015350 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1207075015351 Catalytic site [active] 1207075015352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1207075015353 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1207075015354 Predicted secreted protein [Function unknown]; Region: COG5445 1207075015355 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1207075015356 Predicted secreted protein [Function unknown]; Region: COG5445 1207075015357 Stage II sporulation protein; Region: SpoIID; pfam08486 1207075015358 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1207075015359 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1207075015360 MG2 domain; Region: A2M_N; pfam01835 1207075015361 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1207075015362 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1207075015363 surface patch; other site 1207075015364 thioester region; other site 1207075015365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1207075015366 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909 1207075015367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1207075015368 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1207075015369 Fic family protein [Function unknown]; Region: COG3177 1207075015370 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1207075015371 Fic/DOC family; Region: Fic; pfam02661 1207075015372 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1207075015373 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1207075015374 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1207075015375 substrate binding pocket [chemical binding]; other site 1207075015376 chain length determination region; other site 1207075015377 substrate-Mg2+ binding site; other site 1207075015378 catalytic residues [active] 1207075015379 aspartate-rich region 1; other site 1207075015380 active site lid residues [active] 1207075015381 aspartate-rich region 2; other site 1207075015382 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1207075015383 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1207075015384 TPP-binding site; other site 1207075015385 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1207075015386 PYR/PP interface [polypeptide binding]; other site 1207075015387 dimer interface [polypeptide binding]; other site 1207075015388 TPP binding site [chemical binding]; other site 1207075015389 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1207075015390 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1207075015391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075015392 N-terminal plug; other site 1207075015393 ligand-binding site [chemical binding]; other site 1207075015394 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1207075015395 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1207075015396 cobalamin binding residues [chemical binding]; other site 1207075015397 putative BtuC binding residues; other site 1207075015398 dimer interface [polypeptide binding]; other site 1207075015399 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1207075015400 dimerization interface [polypeptide binding]; other site 1207075015401 active site 1207075015402 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1207075015403 tetramer interfaces [polypeptide binding]; other site 1207075015404 binuclear metal-binding site [ion binding]; other site 1207075015405 thiamine monophosphate kinase; Provisional; Region: PRK05731 1207075015406 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1207075015407 ATP binding site [chemical binding]; other site 1207075015408 dimerization interface [polypeptide binding]; other site 1207075015409 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1207075015410 putative RNA binding site [nucleotide binding]; other site 1207075015411 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1207075015412 homopentamer interface [polypeptide binding]; other site 1207075015413 active site 1207075015414 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1207075015415 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1207075015416 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1207075015417 dimerization interface [polypeptide binding]; other site 1207075015418 active site 1207075015419 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1207075015420 Lumazine binding domain; Region: Lum_binding; pfam00677 1207075015421 Lumazine binding domain; Region: Lum_binding; pfam00677 1207075015422 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1207075015423 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1207075015424 catalytic motif [active] 1207075015425 Zn binding site [ion binding]; other site 1207075015426 RibD C-terminal domain; Region: RibD_C; cl17279 1207075015427 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1207075015428 ATP cone domain; Region: ATP-cone; pfam03477 1207075015429 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1207075015430 Predicted methyltransferase [General function prediction only]; Region: COG3897 1207075015431 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1207075015432 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1207075015433 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1207075015434 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1207075015435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1207075015436 Walker A/P-loop; other site 1207075015437 ATP binding site [chemical binding]; other site 1207075015438 Q-loop/lid; other site 1207075015439 ABC transporter signature motif; other site 1207075015440 Walker B; other site 1207075015441 D-loop; other site 1207075015442 H-loop/switch region; other site 1207075015443 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1207075015444 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1207075015445 FtsX-like permease family; Region: FtsX; pfam02687 1207075015446 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1207075015447 OmpW family; Region: OmpW; cl17427 1207075015448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075015449 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075015450 NAD(P) binding site [chemical binding]; other site 1207075015451 active site 1207075015452 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1207075015453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075015454 NAD(P) binding site [chemical binding]; other site 1207075015455 active site 1207075015456 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1207075015457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075015458 ATP binding site [chemical binding]; other site 1207075015459 putative Mg++ binding site [ion binding]; other site 1207075015460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075015461 nucleotide binding region [chemical binding]; other site 1207075015462 ATP-binding site [chemical binding]; other site 1207075015463 DEAD/H associated; Region: DEAD_assoc; pfam08494 1207075015464 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1207075015465 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075015466 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075015467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075015468 putative substrate translocation pore; other site 1207075015469 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1207075015470 putative catalytic site [active] 1207075015471 putative metal binding site [ion binding]; other site 1207075015472 putative phosphate binding site [ion binding]; other site 1207075015473 cardiolipin synthase 2; Provisional; Region: PRK11263 1207075015474 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1207075015475 putative active site [active] 1207075015476 catalytic site [active] 1207075015477 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1207075015478 putative active site [active] 1207075015479 catalytic site [active] 1207075015480 Predicted integral membrane protein [Function unknown]; Region: COG0392 1207075015481 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1207075015482 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1207075015483 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075015484 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1207075015485 conserved cys residue [active] 1207075015486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075015487 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1207075015488 Isochorismatase family; Region: Isochorismatase; pfam00857 1207075015489 catalytic triad [active] 1207075015490 conserved cis-peptide bond; other site 1207075015491 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1207075015492 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1207075015493 dimer interface [polypeptide binding]; other site 1207075015494 ssDNA binding site [nucleotide binding]; other site 1207075015495 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1207075015496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075015497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075015498 putative substrate translocation pore; other site 1207075015499 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1207075015500 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1207075015501 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1207075015502 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1207075015503 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1207075015504 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1207075015505 heme binding site [chemical binding]; other site 1207075015506 ferroxidase pore; other site 1207075015507 ferroxidase diiron center [ion binding]; other site 1207075015508 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1207075015509 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1207075015510 tetramer interface [polypeptide binding]; other site 1207075015511 heme binding pocket [chemical binding]; other site 1207075015512 NADPH binding site [chemical binding]; other site 1207075015513 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1207075015514 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1207075015515 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1207075015516 alphaNTD homodimer interface [polypeptide binding]; other site 1207075015517 alphaNTD - beta interaction site [polypeptide binding]; other site 1207075015518 alphaNTD - beta' interaction site [polypeptide binding]; other site 1207075015519 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1207075015520 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1207075015521 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1207075015522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1207075015523 RNA binding surface [nucleotide binding]; other site 1207075015524 30S ribosomal protein S11; Validated; Region: PRK05309 1207075015525 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1207075015526 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1207075015527 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1207075015528 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1207075015529 SecY translocase; Region: SecY; pfam00344 1207075015530 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1207075015531 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1207075015532 23S rRNA binding site [nucleotide binding]; other site 1207075015533 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1207075015534 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1207075015535 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1207075015536 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1207075015537 5S rRNA interface [nucleotide binding]; other site 1207075015538 23S rRNA interface [nucleotide binding]; other site 1207075015539 L5 interface [polypeptide binding]; other site 1207075015540 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1207075015541 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1207075015542 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1207075015543 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1207075015544 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1207075015545 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1207075015546 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1207075015547 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1207075015548 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1207075015549 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1207075015550 RNA binding site [nucleotide binding]; other site 1207075015551 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1207075015552 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1207075015553 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1207075015554 23S rRNA interface [nucleotide binding]; other site 1207075015555 putative translocon interaction site; other site 1207075015556 signal recognition particle (SRP54) interaction site; other site 1207075015557 L23 interface [polypeptide binding]; other site 1207075015558 trigger factor interaction site; other site 1207075015559 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1207075015560 23S rRNA interface [nucleotide binding]; other site 1207075015561 5S rRNA interface [nucleotide binding]; other site 1207075015562 putative antibiotic binding site [chemical binding]; other site 1207075015563 L25 interface [polypeptide binding]; other site 1207075015564 L27 interface [polypeptide binding]; other site 1207075015565 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1207075015566 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1207075015567 G-X-X-G motif; other site 1207075015568 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1207075015569 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1207075015570 protein-rRNA interface [nucleotide binding]; other site 1207075015571 putative translocon binding site; other site 1207075015572 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1207075015573 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1207075015574 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1207075015575 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1207075015576 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1207075015577 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1207075015578 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1207075015579 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1207075015580 elongation factor Tu; Reviewed; Region: PRK00049 1207075015581 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1207075015582 G1 box; other site 1207075015583 GEF interaction site [polypeptide binding]; other site 1207075015584 GTP/Mg2+ binding site [chemical binding]; other site 1207075015585 Switch I region; other site 1207075015586 G2 box; other site 1207075015587 G3 box; other site 1207075015588 Switch II region; other site 1207075015589 G4 box; other site 1207075015590 G5 box; other site 1207075015591 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1207075015592 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1207075015593 Antibiotic Binding Site [chemical binding]; other site 1207075015594 elongation factor G; Reviewed; Region: PRK00007 1207075015595 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1207075015596 G1 box; other site 1207075015597 putative GEF interaction site [polypeptide binding]; other site 1207075015598 GTP/Mg2+ binding site [chemical binding]; other site 1207075015599 Switch I region; other site 1207075015600 G2 box; other site 1207075015601 G3 box; other site 1207075015602 Switch II region; other site 1207075015603 G4 box; other site 1207075015604 G5 box; other site 1207075015605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1207075015606 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1207075015607 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1207075015608 30S ribosomal protein S7; Validated; Region: PRK05302 1207075015609 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1207075015610 S17 interaction site [polypeptide binding]; other site 1207075015611 S8 interaction site; other site 1207075015612 16S rRNA interaction site [nucleotide binding]; other site 1207075015613 streptomycin interaction site [chemical binding]; other site 1207075015614 23S rRNA interaction site [nucleotide binding]; other site 1207075015615 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1207075015616 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1207075015617 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1207075015618 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1207075015619 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1207075015620 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1207075015621 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1207075015622 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1207075015623 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1207075015624 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1207075015625 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1207075015626 DNA binding site [nucleotide binding] 1207075015627 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1207075015628 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1207075015629 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1207075015630 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1207075015631 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1207075015632 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1207075015633 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1207075015634 RPB3 interaction site [polypeptide binding]; other site 1207075015635 RPB1 interaction site [polypeptide binding]; other site 1207075015636 RPB11 interaction site [polypeptide binding]; other site 1207075015637 RPB10 interaction site [polypeptide binding]; other site 1207075015638 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1207075015639 peripheral dimer interface [polypeptide binding]; other site 1207075015640 core dimer interface [polypeptide binding]; other site 1207075015641 L10 interface [polypeptide binding]; other site 1207075015642 L11 interface [polypeptide binding]; other site 1207075015643 putative EF-Tu interaction site [polypeptide binding]; other site 1207075015644 putative EF-G interaction site [polypeptide binding]; other site 1207075015645 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1207075015646 23S rRNA interface [nucleotide binding]; other site 1207075015647 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1207075015648 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1207075015649 mRNA/rRNA interface [nucleotide binding]; other site 1207075015650 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1207075015651 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1207075015652 23S rRNA interface [nucleotide binding]; other site 1207075015653 L7/L12 interface [polypeptide binding]; other site 1207075015654 putative thiostrepton binding site; other site 1207075015655 L25 interface [polypeptide binding]; other site 1207075015656 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1207075015657 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1207075015658 putative homodimer interface [polypeptide binding]; other site 1207075015659 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1207075015660 heterodimer interface [polypeptide binding]; other site 1207075015661 homodimer interface [polypeptide binding]; other site 1207075015662 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1207075015663 pantothenate kinase; Reviewed; Region: PRK13322 1207075015664 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1207075015665 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1207075015666 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1207075015667 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1207075015668 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1207075015669 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1207075015670 active site 1207075015671 HIGH motif; other site 1207075015672 dimer interface [polypeptide binding]; other site 1207075015673 KMSKS motif; other site 1207075015674 putative peptidase; Provisional; Region: PRK11649 1207075015675 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1207075015676 Peptidase family M23; Region: Peptidase_M23; pfam01551 1207075015677 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1207075015678 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1207075015679 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1207075015680 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1207075015681 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1207075015682 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1207075015683 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1207075015684 FMN binding site [chemical binding]; other site 1207075015685 substrate binding site [chemical binding]; other site 1207075015686 putative catalytic residue [active] 1207075015687 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1207075015688 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1207075015689 classical (c) SDRs; Region: SDR_c; cd05233 1207075015690 NAD(P) binding site [chemical binding]; other site 1207075015691 active site 1207075015692 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1207075015693 nucleotide binding site/active site [active] 1207075015694 HIT family signature motif; other site 1207075015695 catalytic residue [active] 1207075015696 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1207075015697 diiron binding motif [ion binding]; other site 1207075015698 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1207075015699 OsmC-like protein; Region: OsmC; cl00767 1207075015700 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1207075015701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075015702 ligand binding site [chemical binding]; other site 1207075015703 flexible hinge region; other site 1207075015704 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1207075015705 putative switch regulator; other site 1207075015706 non-specific DNA interactions [nucleotide binding]; other site 1207075015707 DNA binding site [nucleotide binding] 1207075015708 sequence specific DNA binding site [nucleotide binding]; other site 1207075015709 putative cAMP binding site [chemical binding]; other site 1207075015710 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1207075015711 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1207075015712 active site 1207075015713 ribulose/triose binding site [chemical binding]; other site 1207075015714 phosphate binding site [ion binding]; other site 1207075015715 substrate (anthranilate) binding pocket [chemical binding]; other site 1207075015716 product (indole) binding pocket [chemical binding]; other site 1207075015717 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1207075015718 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1207075015719 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1207075015720 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1207075015721 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1207075015722 glutamine binding [chemical binding]; other site 1207075015723 catalytic triad [active] 1207075015724 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1207075015725 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1207075015726 active site 1207075015727 catalytic triad [active] 1207075015728 oxyanion hole [active] 1207075015729 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1207075015730 anthranilate synthase component I; Provisional; Region: PRK13565 1207075015731 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1207075015732 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1207075015733 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1207075015734 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1207075015735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075015736 motif II; other site 1207075015737 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1207075015738 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1207075015739 substrate binding site [chemical binding]; other site 1207075015740 hexamer interface [polypeptide binding]; other site 1207075015741 metal binding site [ion binding]; metal-binding site 1207075015742 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1207075015743 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1207075015744 active site 1207075015745 NAD binding site [chemical binding]; other site 1207075015746 metal binding site [ion binding]; metal-binding site 1207075015747 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075015748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075015749 dimer interface [polypeptide binding]; other site 1207075015750 conserved gate region; other site 1207075015751 putative PBP binding loops; other site 1207075015752 ABC-ATPase subunit interface; other site 1207075015753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075015754 dimer interface [polypeptide binding]; other site 1207075015755 conserved gate region; other site 1207075015756 putative PBP binding loops; other site 1207075015757 ABC-ATPase subunit interface; other site 1207075015758 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075015759 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075015760 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1207075015761 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1207075015762 Walker A/P-loop; other site 1207075015763 ATP binding site [chemical binding]; other site 1207075015764 Q-loop/lid; other site 1207075015765 ABC transporter signature motif; other site 1207075015766 Walker B; other site 1207075015767 D-loop; other site 1207075015768 H-loop/switch region; other site 1207075015769 TOBE domain; Region: TOBE_2; pfam08402 1207075015770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1207075015771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075015772 active site 1207075015773 phosphorylation site [posttranslational modification] 1207075015774 intermolecular recognition site; other site 1207075015775 dimerization interface [polypeptide binding]; other site 1207075015776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1207075015777 DNA binding residues [nucleotide binding] 1207075015778 dimerization interface [polypeptide binding]; other site 1207075015779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075015780 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075015781 substrate binding pocket [chemical binding]; other site 1207075015782 membrane-bound complex binding site; other site 1207075015783 hinge residues; other site 1207075015784 PAS domain; Region: PAS_9; pfam13426 1207075015785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075015786 putative active site [active] 1207075015787 heme pocket [chemical binding]; other site 1207075015788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1207075015789 PAS fold; Region: PAS_3; pfam08447 1207075015790 putative active site [active] 1207075015791 heme pocket [chemical binding]; other site 1207075015792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1207075015793 Histidine kinase; Region: HisKA_3; pfam07730 1207075015794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075015795 Mg2+ binding site [ion binding]; other site 1207075015796 G-X-G motif; other site 1207075015797 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1207075015798 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1207075015799 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1207075015800 putative metal binding site [ion binding]; other site 1207075015801 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1207075015802 HSP70 interaction site [polypeptide binding]; other site 1207075015803 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1207075015804 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1207075015805 Substrate binding site; other site 1207075015806 metal-binding site 1207075015807 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1207075015808 Phosphotransferase enzyme family; Region: APH; pfam01636 1207075015809 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1207075015810 OstA-like protein; Region: OstA; cl00844 1207075015811 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1207075015812 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1207075015813 SurA N-terminal domain; Region: SurA_N; pfam09312 1207075015814 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1207075015815 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1207075015816 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1207075015817 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1207075015818 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1207075015819 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1207075015820 S-adenosylmethionine binding site [chemical binding]; other site 1207075015821 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1207075015822 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1207075015823 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1207075015824 active site 1207075015825 metal binding site [ion binding]; metal-binding site 1207075015826 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1207075015827 active site residue [active] 1207075015828 PrkA family serine protein kinase; Provisional; Region: PRK15455 1207075015829 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1207075015830 hypothetical protein; Provisional; Region: PRK05325 1207075015831 SpoVR family protein; Provisional; Region: PRK11767 1207075015832 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1207075015833 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1207075015834 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1207075015835 active site 1207075015836 NTP binding site [chemical binding]; other site 1207075015837 metal binding triad [ion binding]; metal-binding site 1207075015838 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1207075015839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075015840 Zn2+ binding site [ion binding]; other site 1207075015841 Mg2+ binding site [ion binding]; other site 1207075015842 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1207075015843 catalytic center binding site [active] 1207075015844 ATP binding site [chemical binding]; other site 1207075015845 Dihydroneopterin aldolase; Region: FolB; smart00905 1207075015846 active site 1207075015847 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1207075015848 UGMP family protein; Validated; Region: PRK09604 1207075015849 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1207075015850 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1207075015851 DNA primase, catalytic core; Region: dnaG; TIGR01391 1207075015852 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1207075015853 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1207075015854 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1207075015855 active site 1207075015856 metal binding site [ion binding]; metal-binding site 1207075015857 interdomain interaction site; other site 1207075015858 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1207075015859 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1207075015860 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1207075015861 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1207075015862 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1207075015863 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1207075015864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075015865 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1207075015866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075015867 DNA binding residues [nucleotide binding] 1207075015868 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075015869 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075015870 substrate binding pocket [chemical binding]; other site 1207075015871 membrane-bound complex binding site; other site 1207075015872 hinge residues; other site 1207075015873 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1207075015874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075015875 putative active site [active] 1207075015876 heme pocket [chemical binding]; other site 1207075015877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075015878 putative active site [active] 1207075015879 heme pocket [chemical binding]; other site 1207075015880 PAS domain S-box; Region: sensory_box; TIGR00229 1207075015881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075015882 putative active site [active] 1207075015883 heme pocket [chemical binding]; other site 1207075015884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075015885 PAS domain; Region: PAS_9; pfam13426 1207075015886 putative active site [active] 1207075015887 heme pocket [chemical binding]; other site 1207075015888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075015889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075015890 metal binding site [ion binding]; metal-binding site 1207075015891 active site 1207075015892 I-site; other site 1207075015893 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075015894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075015895 non-specific DNA binding site [nucleotide binding]; other site 1207075015896 salt bridge; other site 1207075015897 sequence-specific DNA binding site [nucleotide binding]; other site 1207075015898 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1207075015899 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1207075015900 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1207075015901 active site 1207075015902 NTP binding site [chemical binding]; other site 1207075015903 metal binding triad [ion binding]; metal-binding site 1207075015904 antibiotic binding site [chemical binding]; other site 1207075015905 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1207075015906 active site 1207075015907 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1207075015908 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1207075015909 Trp docking motif [polypeptide binding]; other site 1207075015910 putative active site [active] 1207075015911 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075015912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075015913 putative DNA binding site [nucleotide binding]; other site 1207075015914 putative Zn2+ binding site [ion binding]; other site 1207075015915 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075015916 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1207075015917 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1207075015918 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1207075015919 putative active site [active] 1207075015920 catalytic triad [active] 1207075015921 putative dimer interface [polypeptide binding]; other site 1207075015922 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1207075015923 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1207075015924 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1207075015925 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1207075015926 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1207075015927 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1207075015928 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1207075015929 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1207075015930 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1207075015931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075015932 FeS/SAM binding site; other site 1207075015933 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1207075015934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1207075015935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1207075015936 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1207075015937 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1207075015938 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075015939 inhibitor-cofactor binding pocket; inhibition site 1207075015940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075015941 catalytic residue [active] 1207075015942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075015943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075015944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075015945 dimerization interface [polypeptide binding]; other site 1207075015946 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1207075015947 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1207075015948 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075015949 active site 1207075015950 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1207075015951 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1207075015952 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1207075015953 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1207075015954 FAD binding site [chemical binding]; other site 1207075015955 substrate binding site [chemical binding]; other site 1207075015956 catalytic residues [active] 1207075015957 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1207075015958 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075015959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075015960 metal binding site [ion binding]; metal-binding site 1207075015961 active site 1207075015962 I-site; other site 1207075015963 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1207075015964 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1207075015965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1207075015966 active site 1207075015967 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1207075015968 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1207075015969 AAA domain; Region: AAA_26; pfam13500 1207075015970 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1207075015971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075015972 S-adenosylmethionine binding site [chemical binding]; other site 1207075015973 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1207075015974 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1207075015975 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1207075015976 substrate-cofactor binding pocket; other site 1207075015977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075015978 catalytic residue [active] 1207075015979 biotin synthase; Provisional; Region: PRK15108 1207075015980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075015981 FeS/SAM binding site; other site 1207075015982 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1207075015983 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1207075015984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075015985 active site 1207075015986 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1207075015987 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1207075015988 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1207075015989 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1207075015990 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1207075015991 serine/threonine protein kinase; Provisional; Region: PRK11768 1207075015992 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1207075015993 EamA-like transporter family; Region: EamA; pfam00892 1207075015994 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1207075015995 ACT domain; Region: ACT_6; pfam13740 1207075015996 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1207075015997 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1207075015998 active site 1207075015999 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075016000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016001 active site 1207075016002 phosphorylation site [posttranslational modification] 1207075016003 intermolecular recognition site; other site 1207075016004 dimerization interface [polypeptide binding]; other site 1207075016005 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1207075016006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1207075016007 ligand binding site [chemical binding]; other site 1207075016008 flexible hinge region; other site 1207075016009 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1207075016010 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1207075016011 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1207075016012 metal binding triad; other site 1207075016013 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1207075016014 active site 1207075016015 catalytic site [active] 1207075016016 substrate binding site [chemical binding]; other site 1207075016017 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1207075016018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075016019 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075016020 DNA binding residues [nucleotide binding] 1207075016021 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1207075016022 FecR protein; Region: FecR; pfam04773 1207075016023 Secretin and TonB N terminus short domain; Region: STN; smart00965 1207075016024 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1207075016025 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1207075016026 N-terminal plug; other site 1207075016027 ligand-binding site [chemical binding]; other site 1207075016028 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1207075016029 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1207075016030 putative glutathione S-transferase; Provisional; Region: PRK10357 1207075016031 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1207075016032 putative C-terminal domain interface [polypeptide binding]; other site 1207075016033 putative GSH binding site (G-site) [chemical binding]; other site 1207075016034 putative dimer interface [polypeptide binding]; other site 1207075016035 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1207075016036 dimer interface [polypeptide binding]; other site 1207075016037 N-terminal domain interface [polypeptide binding]; other site 1207075016038 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075016039 inner membrane protein; Provisional; Region: PRK11715 1207075016040 sensory histidine kinase CreC; Provisional; Region: PRK11100 1207075016041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075016042 dimer interface [polypeptide binding]; other site 1207075016043 phosphorylation site [posttranslational modification] 1207075016044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075016045 ATP binding site [chemical binding]; other site 1207075016046 Mg2+ binding site [ion binding]; other site 1207075016047 G-X-G motif; other site 1207075016048 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1207075016049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016050 active site 1207075016051 phosphorylation site [posttranslational modification] 1207075016052 intermolecular recognition site; other site 1207075016053 dimerization interface [polypeptide binding]; other site 1207075016054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075016055 DNA binding site [nucleotide binding] 1207075016056 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1207075016057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1207075016058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1207075016059 putative acyl-acceptor binding pocket; other site 1207075016060 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1207075016061 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1207075016062 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1207075016063 NAD binding site [chemical binding]; other site 1207075016064 catalytic Zn binding site [ion binding]; other site 1207075016065 structural Zn binding site [ion binding]; other site 1207075016066 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1207075016067 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1207075016068 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1207075016069 putative active site [active] 1207075016070 putative substrate binding site [chemical binding]; other site 1207075016071 putative cosubstrate binding site; other site 1207075016072 catalytic site [active] 1207075016073 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 1207075016074 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1207075016075 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1207075016076 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1207075016077 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1207075016078 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1207075016079 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1207075016080 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075016081 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1207075016082 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1207075016083 dimer interface [polypeptide binding]; other site 1207075016084 active site 1207075016085 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1207075016086 folate binding site [chemical binding]; other site 1207075016087 TraX protein; Region: TraX; cl05434 1207075016088 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1207075016089 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1207075016090 tetramer interface [polypeptide binding]; other site 1207075016091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075016092 catalytic residue [active] 1207075016093 short chain dehydrogenase; Provisional; Region: PRK08278 1207075016094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1207075016095 NAD(P) binding site [chemical binding]; other site 1207075016096 active site 1207075016097 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1207075016098 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1207075016099 FAD binding pocket [chemical binding]; other site 1207075016100 FAD binding motif [chemical binding]; other site 1207075016101 phosphate binding motif [ion binding]; other site 1207075016102 beta-alpha-beta structure motif; other site 1207075016103 NAD binding pocket [chemical binding]; other site 1207075016104 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075016105 catalytic loop [active] 1207075016106 iron binding site [ion binding]; other site 1207075016107 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1207075016108 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1207075016109 [2Fe-2S] cluster binding site [ion binding]; other site 1207075016110 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1207075016111 putative alpha subunit interface [polypeptide binding]; other site 1207075016112 putative active site [active] 1207075016113 putative substrate binding site [chemical binding]; other site 1207075016114 Fe binding site [ion binding]; other site 1207075016115 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1207075016116 catalytic motif [active] 1207075016117 Catalytic residue [active] 1207075016118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075016119 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1207075016120 Coenzyme A binding pocket [chemical binding]; other site 1207075016121 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1207075016122 Ligand Binding Site [chemical binding]; other site 1207075016123 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1207075016124 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1207075016125 Ligand binding site [chemical binding]; other site 1207075016126 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1207075016127 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1207075016128 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1207075016129 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1207075016130 Cysteine-rich domain; Region: CCG; pfam02754 1207075016131 Cysteine-rich domain; Region: CCG; pfam02754 1207075016132 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1207075016133 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1207075016134 putative active site [active] 1207075016135 putative FMN binding site [chemical binding]; other site 1207075016136 putative substrate binding site [chemical binding]; other site 1207075016137 putative catalytic residue [active] 1207075016138 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1207075016139 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1207075016140 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1207075016141 active site 1207075016142 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1207075016143 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1207075016144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075016145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1207075016146 non-specific DNA binding site [nucleotide binding]; other site 1207075016147 salt bridge; other site 1207075016148 sequence-specific DNA binding site [nucleotide binding]; other site 1207075016149 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1207075016150 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075016151 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1207075016152 conserved cys residue [active] 1207075016153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075016154 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1207075016155 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075016156 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1207075016157 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1207075016158 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1207075016159 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1207075016160 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1207075016161 active site 1207075016162 Protein of unknown function (DUF971); Region: DUF971; cl01414 1207075016163 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 1207075016164 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1207075016165 substrate binding pocket [chemical binding]; other site 1207075016166 active site 1207075016167 iron coordination sites [ion binding]; other site 1207075016168 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075016169 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1207075016170 conserved cys residue [active] 1207075016171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075016172 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1207075016173 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1207075016174 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1207075016175 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1207075016176 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1207075016177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016178 dimer interface [polypeptide binding]; other site 1207075016179 conserved gate region; other site 1207075016180 putative PBP binding loops; other site 1207075016181 ABC-ATPase subunit interface; other site 1207075016182 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1207075016183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075016184 Walker A/P-loop; other site 1207075016185 ATP binding site [chemical binding]; other site 1207075016186 Q-loop/lid; other site 1207075016187 ABC transporter signature motif; other site 1207075016188 Walker B; other site 1207075016189 D-loop; other site 1207075016190 H-loop/switch region; other site 1207075016191 BCCT family transporter; Region: BCCT; cl00569 1207075016192 transcriptional regulator BetI; Validated; Region: PRK00767 1207075016193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075016194 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1207075016195 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1207075016196 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1207075016197 tetrameric interface [polypeptide binding]; other site 1207075016198 NAD binding site [chemical binding]; other site 1207075016199 catalytic residues [active] 1207075016200 choline dehydrogenase; Validated; Region: PRK02106 1207075016201 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075016202 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1207075016203 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1207075016204 putative transporter; Provisional; Region: PRK10504 1207075016205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075016206 putative substrate translocation pore; other site 1207075016207 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1207075016208 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1207075016209 ATP binding site [chemical binding]; other site 1207075016210 Mg++ binding site [ion binding]; other site 1207075016211 motif III; other site 1207075016212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075016213 nucleotide binding region [chemical binding]; other site 1207075016214 ATP-binding site [chemical binding]; other site 1207075016215 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1207075016216 putative RNA binding site [nucleotide binding]; other site 1207075016217 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1207075016218 HI0933-like protein; Region: HI0933_like; pfam03486 1207075016219 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1207075016220 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1207075016221 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1207075016222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075016223 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075016224 substrate binding pocket [chemical binding]; other site 1207075016225 membrane-bound complex binding site; other site 1207075016226 hinge residues; other site 1207075016227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075016228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075016229 Coenzyme A binding pocket [chemical binding]; other site 1207075016230 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 1207075016231 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1207075016232 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075016233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016234 active site 1207075016235 phosphorylation site [posttranslational modification] 1207075016236 intermolecular recognition site; other site 1207075016237 dimerization interface [polypeptide binding]; other site 1207075016238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075016239 PAS domain; Region: PAS_9; pfam13426 1207075016240 putative active site [active] 1207075016241 heme pocket [chemical binding]; other site 1207075016242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075016243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075016244 metal binding site [ion binding]; metal-binding site 1207075016245 active site 1207075016246 I-site; other site 1207075016247 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075016248 Alginate lyase; Region: Alginate_lyase2; pfam08787 1207075016249 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1207075016250 intersubunit interface [polypeptide binding]; other site 1207075016251 active site 1207075016252 zinc binding site [ion binding]; other site 1207075016253 Na+ binding site [ion binding]; other site 1207075016254 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1207075016255 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1207075016256 Phosphoglycerate kinase; Region: PGK; pfam00162 1207075016257 substrate binding site [chemical binding]; other site 1207075016258 hinge regions; other site 1207075016259 ADP binding site [chemical binding]; other site 1207075016260 catalytic site [active] 1207075016261 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1207075016262 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1207075016263 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1207075016264 transketolase; Reviewed; Region: PRK12753 1207075016265 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1207075016266 TPP-binding site [chemical binding]; other site 1207075016267 dimer interface [polypeptide binding]; other site 1207075016268 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1207075016269 PYR/PP interface [polypeptide binding]; other site 1207075016270 dimer interface [polypeptide binding]; other site 1207075016271 TPP binding site [chemical binding]; other site 1207075016272 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1207075016273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075016274 putative DNA binding site [nucleotide binding]; other site 1207075016275 putative Zn2+ binding site [ion binding]; other site 1207075016276 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075016277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075016278 S-adenosylmethionine binding site [chemical binding]; other site 1207075016279 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1207075016280 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1207075016281 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1207075016282 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1207075016283 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1207075016284 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1207075016285 nucleotide binding pocket [chemical binding]; other site 1207075016286 K-X-D-G motif; other site 1207075016287 catalytic site [active] 1207075016288 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1207075016289 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1207075016290 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1207075016291 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1207075016292 MltA specific insert domain; Region: MltA; smart00925 1207075016293 3D domain; Region: 3D; pfam06725 1207075016294 Predicted membrane protein [Function unknown]; Region: COG3686 1207075016295 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1207075016296 EamA-like transporter family; Region: EamA; pfam00892 1207075016297 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1207075016298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075016299 putative substrate translocation pore; other site 1207075016300 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1207075016301 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1207075016302 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1207075016303 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1207075016304 homotetramer interface [polypeptide binding]; other site 1207075016305 ligand binding site [chemical binding]; other site 1207075016306 catalytic site [active] 1207075016307 NAD binding site [chemical binding]; other site 1207075016308 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1207075016309 FAD binding site [chemical binding]; other site 1207075016310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075016311 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075016312 substrate binding pocket [chemical binding]; other site 1207075016313 membrane-bound complex binding site; other site 1207075016314 hinge residues; other site 1207075016315 helicase 45; Provisional; Region: PTZ00424 1207075016316 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1207075016317 ATP binding site [chemical binding]; other site 1207075016318 Mg++ binding site [ion binding]; other site 1207075016319 motif III; other site 1207075016320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075016321 nucleotide binding region [chemical binding]; other site 1207075016322 ATP-binding site [chemical binding]; other site 1207075016323 YceI-like domain; Region: YceI; cl01001 1207075016324 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1207075016325 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1207075016326 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1207075016327 dimerization interface [polypeptide binding]; other site 1207075016328 mannose binding site [chemical binding]; other site 1207075016329 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1207075016330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1207075016331 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1207075016332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075016333 inhibitor-cofactor binding pocket; inhibition site 1207075016334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075016335 catalytic residue [active] 1207075016336 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1207075016337 RNA methyltransferase, RsmE family; Region: TIGR00046 1207075016338 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1207075016339 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1207075016340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075016341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075016342 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1207075016343 putative dimerization interface [polypeptide binding]; other site 1207075016344 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 1207075016345 Malonate transporter MadL subunit; Region: MadL; pfam03817 1207075016346 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1207075016347 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1207075016348 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1207075016349 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1207075016350 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1207075016351 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1207075016352 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1207075016353 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1207075016354 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1207075016355 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1207075016356 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075016357 putative binding surface; other site 1207075016358 active site 1207075016359 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075016360 putative binding surface; other site 1207075016361 active site 1207075016362 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1207075016363 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075016364 putative binding surface; other site 1207075016365 active site 1207075016366 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1207075016367 putative binding surface; other site 1207075016368 active site 1207075016369 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1207075016370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075016371 ATP binding site [chemical binding]; other site 1207075016372 Mg2+ binding site [ion binding]; other site 1207075016373 G-X-G motif; other site 1207075016374 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1207075016375 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075016376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016377 active site 1207075016378 phosphorylation site [posttranslational modification] 1207075016379 intermolecular recognition site; other site 1207075016380 dimerization interface [polypeptide binding]; other site 1207075016381 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1207075016382 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1207075016383 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1207075016384 dimer interface [polypeptide binding]; other site 1207075016385 putative CheW interface [polypeptide binding]; other site 1207075016386 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1207075016387 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075016388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016389 active site 1207075016390 phosphorylation site [posttranslational modification] 1207075016391 intermolecular recognition site; other site 1207075016392 dimerization interface [polypeptide binding]; other site 1207075016393 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075016394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016395 active site 1207075016396 phosphorylation site [posttranslational modification] 1207075016397 intermolecular recognition site; other site 1207075016398 dimerization interface [polypeptide binding]; other site 1207075016399 glutathione synthetase; Provisional; Region: PRK05246 1207075016400 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1207075016401 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1207075016402 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1207075016403 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1207075016404 hypothetical protein; Validated; Region: PRK00228 1207075016405 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1207075016406 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1207075016407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075016408 active site 1207075016409 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1207075016410 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1207075016411 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1207075016412 dihydroorotase; Validated; Region: pyrC; PRK09357 1207075016413 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1207075016414 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1207075016415 active site 1207075016416 TM2 domain; Region: TM2; cl00984 1207075016417 TM2 domain; Region: TM2; cl00984 1207075016418 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1207075016419 NlpC/P60 family; Region: NLPC_P60; pfam00877 1207075016420 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1207075016421 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1207075016422 Walker A motif; other site 1207075016423 ATP binding site [chemical binding]; other site 1207075016424 Walker B motif; other site 1207075016425 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1207075016426 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1207075016427 catalytic residue [active] 1207075016428 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1207075016429 pyrroline-5-carboxylate reductase; Region: PLN02688 1207075016430 YGGT family; Region: YGGT; pfam02325 1207075016431 YGGT family; Region: YGGT; pfam02325 1207075016432 hypothetical protein; Validated; Region: PRK05090 1207075016433 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1207075016434 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1207075016435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1207075016436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075016437 S-adenosylmethionine binding site [chemical binding]; other site 1207075016438 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1207075016439 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1207075016440 active site 1207075016441 dimerization interface [polypeptide binding]; other site 1207075016442 HemN family oxidoreductase; Provisional; Region: PRK05660 1207075016443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1207075016444 FeS/SAM binding site; other site 1207075016445 HemN C-terminal domain; Region: HemN_C; pfam06969 1207075016446 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1207075016447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075016448 S-adenosylmethionine binding site [chemical binding]; other site 1207075016449 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1207075016450 ThiS interaction site; other site 1207075016451 putative active site [active] 1207075016452 tetramer interface [polypeptide binding]; other site 1207075016453 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1207075016454 thiS-thiF/thiG interaction site; other site 1207075016455 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1207075016456 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1207075016457 Transglycosylase; Region: Transgly; cl17702 1207075016458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075016459 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075016460 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075016461 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1207075016462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1207075016463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1207075016464 DNA binding residues [nucleotide binding] 1207075016465 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1207075016466 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1207075016467 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1207075016468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075016469 Walker A/P-loop; other site 1207075016470 ATP binding site [chemical binding]; other site 1207075016471 Q-loop/lid; other site 1207075016472 ABC transporter signature motif; other site 1207075016473 Walker B; other site 1207075016474 D-loop; other site 1207075016475 H-loop/switch region; other site 1207075016476 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1207075016477 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1207075016478 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1207075016479 P loop; other site 1207075016480 GTP binding site [chemical binding]; other site 1207075016481 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1207075016482 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1207075016483 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1207075016484 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1207075016485 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1207075016486 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1207075016487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075016488 S-adenosylmethionine binding site [chemical binding]; other site 1207075016489 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1207075016490 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1207075016491 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1207075016492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075016493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075016494 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1207075016495 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1207075016496 active site residue [active] 1207075016497 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1207075016498 active site residue [active] 1207075016499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075016500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075016501 Bacterial transcriptional repressor; Region: TetR; pfam13972 1207075016502 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1207075016503 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1207075016504 NAD(P) binding site [chemical binding]; other site 1207075016505 catalytic residues [active] 1207075016506 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1207075016507 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1207075016508 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1207075016509 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1207075016510 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1207075016511 active site 1207075016512 (T/H)XGH motif; other site 1207075016513 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1207075016514 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1207075016515 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1207075016516 DNA binding site [nucleotide binding] 1207075016517 catalytic residue [active] 1207075016518 H2TH interface [polypeptide binding]; other site 1207075016519 putative catalytic residues [active] 1207075016520 turnover-facilitating residue; other site 1207075016521 intercalation triad [nucleotide binding]; other site 1207075016522 8OG recognition residue [nucleotide binding]; other site 1207075016523 putative reading head residues; other site 1207075016524 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1207075016525 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1207075016526 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1207075016527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075016528 Zn2+ binding site [ion binding]; other site 1207075016529 Mg2+ binding site [ion binding]; other site 1207075016530 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1207075016531 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1207075016532 putative RNA binding site [nucleotide binding]; other site 1207075016533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075016534 S-adenosylmethionine binding site [chemical binding]; other site 1207075016535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075016536 putative substrate translocation pore; other site 1207075016537 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1207075016538 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1207075016539 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1207075016540 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1207075016541 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1207075016542 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1207075016543 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1207075016544 folate binding site [chemical binding]; other site 1207075016545 NADP+ binding site [chemical binding]; other site 1207075016546 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1207075016547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1207075016548 G1 box; other site 1207075016549 GTP/Mg2+ binding site [chemical binding]; other site 1207075016550 G2 box; other site 1207075016551 Switch I region; other site 1207075016552 G3 box; other site 1207075016553 Switch II region; other site 1207075016554 G4 box; other site 1207075016555 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1207075016556 G5 box; other site 1207075016557 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 1207075016558 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1207075016559 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 1207075016560 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1207075016561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016562 dimer interface [polypeptide binding]; other site 1207075016563 conserved gate region; other site 1207075016564 putative PBP binding loops; other site 1207075016565 ABC-ATPase subunit interface; other site 1207075016566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016567 dimer interface [polypeptide binding]; other site 1207075016568 conserved gate region; other site 1207075016569 putative PBP binding loops; other site 1207075016570 ABC-ATPase subunit interface; other site 1207075016571 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1207075016572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075016573 Walker A/P-loop; other site 1207075016574 ATP binding site [chemical binding]; other site 1207075016575 Q-loop/lid; other site 1207075016576 ABC transporter signature motif; other site 1207075016577 Walker B; other site 1207075016578 D-loop; other site 1207075016579 H-loop/switch region; other site 1207075016580 TOBE domain; Region: TOBE_2; pfam08402 1207075016581 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1207075016582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075016583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075016584 dimerization interface [polypeptide binding]; other site 1207075016585 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1207075016586 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1207075016587 metal-binding site [ion binding] 1207075016588 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1207075016589 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1207075016590 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1207075016591 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1207075016592 DNA binding residues [nucleotide binding] 1207075016593 dimer interface [polypeptide binding]; other site 1207075016594 putative metal binding site [ion binding]; other site 1207075016595 thymidylate synthase; Provisional; Region: thyA; PRK13821 1207075016596 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1207075016597 dimerization interface [polypeptide binding]; other site 1207075016598 active site 1207075016599 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1207075016600 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1207075016601 NRDE protein; Region: NRDE; cl01315 1207075016602 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1207075016603 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1207075016604 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1207075016605 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1207075016606 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1207075016607 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1207075016608 putative active site [active] 1207075016609 Ap4A binding site [chemical binding]; other site 1207075016610 nudix motif; other site 1207075016611 putative metal binding site [ion binding]; other site 1207075016612 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1207075016613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075016614 motif II; other site 1207075016615 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1207075016616 threonine dehydratase; Reviewed; Region: PRK09224 1207075016617 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1207075016618 tetramer interface [polypeptide binding]; other site 1207075016619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075016620 catalytic residue [active] 1207075016621 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1207075016622 putative Ile/Val binding site [chemical binding]; other site 1207075016623 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1207075016624 putative Ile/Val binding site [chemical binding]; other site 1207075016625 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1207075016626 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1207075016627 active site 1207075016628 dimer interface [polypeptide binding]; other site 1207075016629 SdiA-regulated; Region: SdiA-regulated; pfam06977 1207075016630 SdiA-regulated; Region: SdiA-regulated; cd09971 1207075016631 putative active site [active] 1207075016632 SdiA-regulated; Region: SdiA-regulated; pfam06977 1207075016633 SdiA-regulated; Region: SdiA-regulated; cd09971 1207075016634 putative active site [active] 1207075016635 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1207075016636 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1207075016637 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1207075016638 FAD binding domain; Region: FAD_binding_4; pfam01565 1207075016639 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1207075016640 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1207075016641 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1207075016642 ligand binding site [chemical binding]; other site 1207075016643 NAD binding site [chemical binding]; other site 1207075016644 tetramer interface [polypeptide binding]; other site 1207075016645 catalytic site [active] 1207075016646 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1207075016647 L-serine binding site [chemical binding]; other site 1207075016648 ACT domain interface; other site 1207075016649 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1207075016650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075016651 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075016652 substrate binding pocket [chemical binding]; other site 1207075016653 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1207075016654 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1207075016655 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1207075016656 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1207075016657 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1207075016658 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1207075016659 S-type Pyocin; Region: Pyocin_S; pfam06958 1207075016660 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1207075016661 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1207075016662 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1207075016663 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1207075016664 active site 1207075016665 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1207075016666 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1207075016667 conserved cys residue [active] 1207075016668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075016669 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1207075016670 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075016671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016672 dimer interface [polypeptide binding]; other site 1207075016673 conserved gate region; other site 1207075016674 putative PBP binding loops; other site 1207075016675 ABC-ATPase subunit interface; other site 1207075016676 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1207075016677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016678 dimer interface [polypeptide binding]; other site 1207075016679 conserved gate region; other site 1207075016680 putative PBP binding loops; other site 1207075016681 ABC-ATPase subunit interface; other site 1207075016682 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1207075016683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075016684 Walker A/P-loop; other site 1207075016685 ATP binding site [chemical binding]; other site 1207075016686 Q-loop/lid; other site 1207075016687 ABC transporter signature motif; other site 1207075016688 Walker B; other site 1207075016689 D-loop; other site 1207075016690 H-loop/switch region; other site 1207075016691 TOBE domain; Region: TOBE_2; pfam08402 1207075016692 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075016693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075016694 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075016695 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075016696 putative aminotransferase; Validated; Region: PRK07480 1207075016697 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1207075016698 inhibitor-cofactor binding pocket; inhibition site 1207075016699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075016700 catalytic residue [active] 1207075016701 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075016702 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1207075016703 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075016704 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1207075016705 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1207075016706 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1207075016707 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1207075016708 active site 1207075016709 zinc binding site [ion binding]; other site 1207075016710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1207075016711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1207075016712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075016713 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075016714 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075016715 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1207075016716 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1207075016717 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1207075016718 Walker A/P-loop; other site 1207075016719 ATP binding site [chemical binding]; other site 1207075016720 Q-loop/lid; other site 1207075016721 ABC transporter signature motif; other site 1207075016722 Walker B; other site 1207075016723 D-loop; other site 1207075016724 H-loop/switch region; other site 1207075016725 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1207075016726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016727 dimer interface [polypeptide binding]; other site 1207075016728 conserved gate region; other site 1207075016729 putative PBP binding loops; other site 1207075016730 ABC-ATPase subunit interface; other site 1207075016731 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1207075016732 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1207075016733 active site 1207075016734 dimer interface [polypeptide binding]; other site 1207075016735 non-prolyl cis peptide bond; other site 1207075016736 insertion regions; other site 1207075016737 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1207075016738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075016739 substrate binding pocket [chemical binding]; other site 1207075016740 membrane-bound complex binding site; other site 1207075016741 hinge residues; other site 1207075016742 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1207075016743 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1207075016744 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1207075016745 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1207075016746 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1207075016747 dimer interface [polypeptide binding]; other site 1207075016748 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1207075016749 catalytic triad [active] 1207075016750 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075016751 outer membrane porin, OprD family; Region: OprD; pfam03573 1207075016752 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1207075016753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075016754 substrate binding pocket [chemical binding]; other site 1207075016755 membrane-bound complex binding site; other site 1207075016756 hinge residues; other site 1207075016757 N-acetylglutamate synthase; Validated; Region: PRK05279 1207075016758 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1207075016759 putative feedback inhibition sensing region; other site 1207075016760 putative nucleotide binding site [chemical binding]; other site 1207075016761 putative substrate binding site [chemical binding]; other site 1207075016762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075016763 Coenzyme A binding pocket [chemical binding]; other site 1207075016764 acetylornithine deacetylase; Provisional; Region: PRK05111 1207075016765 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1207075016766 metal binding site [ion binding]; metal-binding site 1207075016767 putative dimer interface [polypeptide binding]; other site 1207075016768 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1207075016769 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1207075016770 putative active site [active] 1207075016771 putative metal binding residues [ion binding]; other site 1207075016772 signature motif; other site 1207075016773 putative triphosphate binding site [ion binding]; other site 1207075016774 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075016775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075016776 putative DNA binding site [nucleotide binding]; other site 1207075016777 putative Zn2+ binding site [ion binding]; other site 1207075016778 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075016779 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1207075016780 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1207075016781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1207075016782 Walker A motif; other site 1207075016783 ATP binding site [chemical binding]; other site 1207075016784 Walker B motif; other site 1207075016785 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1207075016786 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1207075016787 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1207075016788 conserverd hypothetical protein; Region: TIGR02448 1207075016789 glycine dehydrogenase; Provisional; Region: PRK12566 1207075016790 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1207075016791 tetramer interface [polypeptide binding]; other site 1207075016792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075016793 catalytic residue [active] 1207075016794 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1207075016795 tetramer interface [polypeptide binding]; other site 1207075016796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075016797 catalytic residue [active] 1207075016798 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1207075016799 lipoyl attachment site [posttranslational modification]; other site 1207075016800 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1207075016801 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1207075016802 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1207075016803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016804 dimer interface [polypeptide binding]; other site 1207075016805 conserved gate region; other site 1207075016806 putative PBP binding loops; other site 1207075016807 ABC-ATPase subunit interface; other site 1207075016808 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1207075016809 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1207075016810 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1207075016811 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1207075016812 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1207075016813 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1207075016814 proline aminopeptidase P II; Provisional; Region: PRK10879 1207075016815 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1207075016816 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1207075016817 active site 1207075016818 hypothetical protein; Reviewed; Region: PRK02166 1207075016819 TIGR02449 family protein; Region: TIGR02449 1207075016820 Cell division protein ZapA; Region: ZapA; pfam05164 1207075016821 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1207075016822 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1207075016823 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1207075016824 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1207075016825 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1207075016826 NAD(P) binding site [chemical binding]; other site 1207075016827 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1207075016828 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1207075016829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075016830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075016831 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1207075016832 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1207075016833 putative active site pocket [active] 1207075016834 dimerization interface [polypeptide binding]; other site 1207075016835 putative catalytic residue [active] 1207075016836 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1207075016837 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075016838 catalytic loop [active] 1207075016839 iron binding site [ion binding]; other site 1207075016840 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1207075016841 FAD binding pocket [chemical binding]; other site 1207075016842 FAD binding motif [chemical binding]; other site 1207075016843 phosphate binding motif [ion binding]; other site 1207075016844 beta-alpha-beta structure motif; other site 1207075016845 NAD binding pocket [chemical binding]; other site 1207075016846 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1207075016847 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1207075016848 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1207075016849 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1207075016850 RNA binding site [nucleotide binding]; other site 1207075016851 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1207075016852 multimer interface [polypeptide binding]; other site 1207075016853 Walker A motif; other site 1207075016854 ATP binding site [chemical binding]; other site 1207075016855 Walker B motif; other site 1207075016856 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1207075016857 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1207075016858 catalytic residues [active] 1207075016859 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1207075016860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075016861 DNA-binding site [nucleotide binding]; DNA binding site 1207075016862 FCD domain; Region: FCD; pfam07729 1207075016863 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1207075016864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1207075016865 substrate binding pocket [chemical binding]; other site 1207075016866 membrane-bound complex binding site; other site 1207075016867 hinge residues; other site 1207075016868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016869 dimer interface [polypeptide binding]; other site 1207075016870 conserved gate region; other site 1207075016871 ABC-ATPase subunit interface; other site 1207075016872 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1207075016873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075016874 dimer interface [polypeptide binding]; other site 1207075016875 conserved gate region; other site 1207075016876 putative PBP binding loops; other site 1207075016877 ABC-ATPase subunit interface; other site 1207075016878 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1207075016879 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1207075016880 Walker A/P-loop; other site 1207075016881 ATP binding site [chemical binding]; other site 1207075016882 Q-loop/lid; other site 1207075016883 ABC transporter signature motif; other site 1207075016884 Walker B; other site 1207075016885 D-loop; other site 1207075016886 H-loop/switch region; other site 1207075016887 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1207075016888 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1207075016889 polyphosphate kinase; Provisional; Region: PRK05443 1207075016890 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1207075016891 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1207075016892 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1207075016893 putative active site [active] 1207075016894 catalytic site [active] 1207075016895 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1207075016896 putative domain interface [polypeptide binding]; other site 1207075016897 putative active site [active] 1207075016898 catalytic site [active] 1207075016899 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1207075016900 dimer interface [polypeptide binding]; other site 1207075016901 active site 1207075016902 aspartate-rich active site metal binding site; other site 1207075016903 allosteric magnesium binding site [ion binding]; other site 1207075016904 Schiff base residues; other site 1207075016905 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1207075016906 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1207075016907 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1207075016908 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1207075016909 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1207075016910 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1207075016911 conserved cys residue [active] 1207075016912 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1207075016913 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1207075016914 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1207075016915 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1207075016916 LysE type translocator; Region: LysE; cl00565 1207075016917 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1207075016918 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1207075016919 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1207075016920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1207075016921 Walker A/P-loop; other site 1207075016922 ATP binding site [chemical binding]; other site 1207075016923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075016924 ABC transporter signature motif; other site 1207075016925 Walker B; other site 1207075016926 D-loop; other site 1207075016927 ABC transporter; Region: ABC_tran_2; pfam12848 1207075016928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1207075016929 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1207075016930 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1207075016931 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1207075016932 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1207075016933 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1207075016934 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1207075016935 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1207075016936 HemY protein N-terminus; Region: HemY_N; pfam07219 1207075016937 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1207075016938 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1207075016939 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1207075016940 active site 1207075016941 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1207075016942 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1207075016943 domain interfaces; other site 1207075016944 active site 1207075016945 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1207075016946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075016947 active site 1207075016948 phosphorylation site [posttranslational modification] 1207075016949 intermolecular recognition site; other site 1207075016950 dimerization interface [polypeptide binding]; other site 1207075016951 LytTr DNA-binding domain; Region: LytTR; pfam04397 1207075016952 argininosuccinate lyase; Provisional; Region: PRK00855 1207075016953 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1207075016954 active sites [active] 1207075016955 tetramer interface [polypeptide binding]; other site 1207075016956 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075016957 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1207075016958 C-terminal domain interface [polypeptide binding]; other site 1207075016959 GSH binding site (G-site) [chemical binding]; other site 1207075016960 dimer interface [polypeptide binding]; other site 1207075016961 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1207075016962 N-terminal domain interface [polypeptide binding]; other site 1207075016963 dimer interface [polypeptide binding]; other site 1207075016964 substrate binding pocket (H-site) [chemical binding]; other site 1207075016965 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1207075016966 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1207075016967 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1207075016968 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1207075016969 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1207075016970 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1207075016971 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1207075016972 frataxin-like protein; Provisional; Region: cyaY; PRK00446 1207075016973 putative iron binding site [ion binding]; other site 1207075016974 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1207075016975 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1207075016976 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1207075016977 active site 1207075016978 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1207075016979 substrate binding site [chemical binding]; other site 1207075016980 catalytic residues [active] 1207075016981 dimer interface [polypeptide binding]; other site 1207075016982 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1207075016983 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1207075016984 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1207075016985 Protein of unknown function, DUF484; Region: DUF484; cl17449 1207075016986 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1207075016987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1207075016988 active site 1207075016989 DNA binding site [nucleotide binding] 1207075016990 Int/Topo IB signature motif; other site 1207075016991 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1207075016992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1207075016993 motif II; other site 1207075016994 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1207075016995 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1207075016996 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1207075016997 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1207075016998 Membrane fusogenic activity; Region: BMFP; pfam04380 1207075016999 BRO family, N-terminal domain; Region: Bro-N; smart01040 1207075017000 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1207075017001 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 1207075017002 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1207075017003 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1207075017004 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1207075017005 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1207075017006 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1207075017007 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1207075017008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075017009 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1207075017010 dimerization interface [polypeptide binding]; other site 1207075017011 substrate binding pocket [chemical binding]; other site 1207075017012 multidrug efflux protein NorA; Provisional; Region: PRK00187 1207075017013 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1207075017014 cation binding site [ion binding]; other site 1207075017015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075017016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075017017 metal binding site [ion binding]; metal-binding site 1207075017018 active site 1207075017019 I-site; other site 1207075017020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075017021 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1207075017022 Part of AAA domain; Region: AAA_19; pfam13245 1207075017023 Family description; Region: UvrD_C_2; pfam13538 1207075017024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075017025 active site 1207075017026 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1207075017027 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1207075017028 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1207075017029 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1207075017030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1207075017031 non-specific DNA binding site [nucleotide binding]; other site 1207075017032 salt bridge; other site 1207075017033 sequence-specific DNA binding site [nucleotide binding]; other site 1207075017034 Cupin domain; Region: Cupin_2; pfam07883 1207075017035 alanine racemase; Reviewed; Region: dadX; PRK03646 1207075017036 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1207075017037 active site 1207075017038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1207075017039 substrate binding site [chemical binding]; other site 1207075017040 catalytic residues [active] 1207075017041 dimer interface [polypeptide binding]; other site 1207075017042 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1207075017043 homotrimer interaction site [polypeptide binding]; other site 1207075017044 putative active site [active] 1207075017045 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1207075017046 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1207075017047 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1207075017048 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1207075017049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075017050 putative DNA binding site [nucleotide binding]; other site 1207075017051 putative Zn2+ binding site [ion binding]; other site 1207075017052 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075017053 Flagellin N-methylase; Region: FliB; pfam03692 1207075017054 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1207075017055 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1207075017056 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1207075017057 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075017058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075017059 DNA-binding site [nucleotide binding]; DNA binding site 1207075017060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075017061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075017062 homodimer interface [polypeptide binding]; other site 1207075017063 catalytic residue [active] 1207075017064 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1207075017065 PLD-like domain; Region: PLDc_2; pfam13091 1207075017066 putative active site [active] 1207075017067 catalytic site [active] 1207075017068 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1207075017069 PLD-like domain; Region: PLDc_2; pfam13091 1207075017070 putative active site [active] 1207075017071 catalytic site [active] 1207075017072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075017073 putative substrate translocation pore; other site 1207075017074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1207075017075 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1207075017076 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1207075017077 NAD(P) binding site [chemical binding]; other site 1207075017078 catalytic residues [active] 1207075017079 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1207075017080 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1207075017081 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1207075017082 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1207075017083 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1207075017084 peptide binding site [polypeptide binding]; other site 1207075017085 hypothetical protein; Reviewed; Region: PRK00024 1207075017086 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1207075017087 MPN+ (JAMM) motif; other site 1207075017088 Zinc-binding site [ion binding]; other site 1207075017089 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1207075017090 Flavoprotein; Region: Flavoprotein; pfam02441 1207075017091 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1207075017092 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1207075017093 trimer interface [polypeptide binding]; other site 1207075017094 active site 1207075017095 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1207075017096 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1207075017097 active site 1207075017098 substrate binding site [chemical binding]; other site 1207075017099 metal binding site [ion binding]; metal-binding site 1207075017100 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1207075017101 feedback inhibition sensing region; other site 1207075017102 homohexameric interface [polypeptide binding]; other site 1207075017103 nucleotide binding site [chemical binding]; other site 1207075017104 N-acetyl-L-glutamate binding site [chemical binding]; other site 1207075017105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1207075017106 active site 1207075017107 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1207075017108 putative active site [active] 1207075017109 putative catalytic site [active] 1207075017110 putative DNA binding site [nucleotide binding]; other site 1207075017111 putative phosphate binding site [ion binding]; other site 1207075017112 metal binding site A [ion binding]; metal-binding site 1207075017113 putative AP binding site [nucleotide binding]; other site 1207075017114 putative metal binding site B [ion binding]; other site 1207075017115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075017116 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075017117 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075017118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1207075017119 ribonuclease PH; Reviewed; Region: rph; PRK00173 1207075017120 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1207075017121 hexamer interface [polypeptide binding]; other site 1207075017122 active site 1207075017123 hypothetical protein; Provisional; Region: PRK11820 1207075017124 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1207075017125 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1207075017126 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1207075017127 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1207075017128 catalytic site [active] 1207075017129 G-X2-G-X-G-K; other site 1207075017130 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1207075017131 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1207075017132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1207075017133 Zn2+ binding site [ion binding]; other site 1207075017134 Mg2+ binding site [ion binding]; other site 1207075017135 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1207075017136 synthetase active site [active] 1207075017137 NTP binding site [chemical binding]; other site 1207075017138 metal binding site [ion binding]; metal-binding site 1207075017139 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1207075017140 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1207075017141 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1207075017142 homotrimer interaction site [polypeptide binding]; other site 1207075017143 putative active site [active] 1207075017144 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1207075017145 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1207075017146 putative NAD(P) binding site [chemical binding]; other site 1207075017147 tonB-system energizer ExbB; Region: exbB; TIGR02797 1207075017148 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1207075017149 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1207075017150 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1207075017151 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1207075017152 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1207075017153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075017154 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1207075017155 dimerization interface [polypeptide binding]; other site 1207075017156 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1207075017157 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1207075017158 generic binding surface II; other site 1207075017159 ssDNA binding site; other site 1207075017160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1207075017161 ATP binding site [chemical binding]; other site 1207075017162 putative Mg++ binding site [ion binding]; other site 1207075017163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1207075017164 nucleotide binding region [chemical binding]; other site 1207075017165 ATP-binding site [chemical binding]; other site 1207075017166 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1207075017167 putative deacylase active site [active] 1207075017168 HDOD domain; Region: HDOD; pfam08668 1207075017169 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075017170 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1207075017171 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1207075017172 IHF dimer interface [polypeptide binding]; other site 1207075017173 IHF - DNA interface [nucleotide binding]; other site 1207075017174 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1207075017175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075017176 Rubredoxin [Energy production and conversion]; Region: COG1773 1207075017177 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1207075017178 iron binding site [ion binding]; other site 1207075017179 Chorismate lyase; Region: Chor_lyase; cl01230 1207075017180 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1207075017181 UbiA prenyltransferase family; Region: UbiA; pfam01040 1207075017182 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1207075017183 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1207075017184 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1207075017185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075017186 active site 1207075017187 phosphorylation site [posttranslational modification] 1207075017188 intermolecular recognition site; other site 1207075017189 dimerization interface [polypeptide binding]; other site 1207075017190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1207075017191 DNA binding site [nucleotide binding] 1207075017192 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1207075017193 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1207075017194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075017195 putative active site [active] 1207075017196 heme pocket [chemical binding]; other site 1207075017197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1207075017198 dimer interface [polypeptide binding]; other site 1207075017199 phosphorylation site [posttranslational modification] 1207075017200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1207075017201 ATP binding site [chemical binding]; other site 1207075017202 Mg2+ binding site [ion binding]; other site 1207075017203 G-X-G motif; other site 1207075017204 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1207075017205 Domain of unknown function DUF21; Region: DUF21; pfam01595 1207075017206 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1207075017207 Transporter associated domain; Region: CorC_HlyC; smart01091 1207075017208 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1207075017209 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1207075017210 Peptidase family M23; Region: Peptidase_M23; pfam01551 1207075017211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1207075017212 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1207075017213 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1207075017214 Response regulator receiver domain; Region: Response_reg; pfam00072 1207075017215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1207075017216 active site 1207075017217 phosphorylation site [posttranslational modification] 1207075017218 intermolecular recognition site; other site 1207075017219 dimerization interface [polypeptide binding]; other site 1207075017220 transcriptional regulator PhoU; Provisional; Region: PRK11115 1207075017221 PhoU domain; Region: PhoU; pfam01895 1207075017222 PhoU domain; Region: PhoU; pfam01895 1207075017223 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1207075017224 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1207075017225 Walker A/P-loop; other site 1207075017226 ATP binding site [chemical binding]; other site 1207075017227 Q-loop/lid; other site 1207075017228 ABC transporter signature motif; other site 1207075017229 Walker B; other site 1207075017230 D-loop; other site 1207075017231 H-loop/switch region; other site 1207075017232 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1207075017233 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1207075017234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075017235 dimer interface [polypeptide binding]; other site 1207075017236 conserved gate region; other site 1207075017237 putative PBP binding loops; other site 1207075017238 ABC-ATPase subunit interface; other site 1207075017239 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1207075017240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1207075017241 dimer interface [polypeptide binding]; other site 1207075017242 conserved gate region; other site 1207075017243 putative PBP binding loops; other site 1207075017244 ABC-ATPase subunit interface; other site 1207075017245 phosphate binding protein; Region: ptsS_2; TIGR02136 1207075017246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1207075017247 metabolite-proton symporter; Region: 2A0106; TIGR00883 1207075017248 putative substrate translocation pore; other site 1207075017249 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1207075017250 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1207075017251 active site 1207075017252 phosphate binding residues; other site 1207075017253 catalytic residues [active] 1207075017254 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1207075017255 Predicted membrane protein [Function unknown]; Region: COG2261 1207075017256 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1207075017257 ATP-grasp domain; Region: ATP-grasp; pfam02222 1207075017258 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1207075017259 cell density-dependent motility repressor; Provisional; Region: PRK10082 1207075017260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075017261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1207075017262 dimerization interface [polypeptide binding]; other site 1207075017263 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1207075017264 Aspartase; Region: Aspartase; cd01357 1207075017265 active sites [active] 1207075017266 tetramer interface [polypeptide binding]; other site 1207075017267 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1207075017268 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1207075017269 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1207075017270 active site 1207075017271 homodimer interface [polypeptide binding]; other site 1207075017272 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1207075017273 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1207075017274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1207075017275 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1207075017276 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1207075017277 active site 1207075017278 Zn binding site [ion binding]; other site 1207075017279 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1207075017280 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1207075017281 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1207075017282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1207075017283 DNA-binding site [nucleotide binding]; DNA binding site 1207075017284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1207075017285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1207075017286 homodimer interface [polypeptide binding]; other site 1207075017287 catalytic residue [active] 1207075017288 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1207075017289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1207075017290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1207075017291 Coenzyme A binding pocket [chemical binding]; other site 1207075017292 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1207075017293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1207075017294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1207075017295 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1207075017296 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1207075017297 active site 1207075017298 catalytic residues [active] 1207075017299 metal binding site [ion binding]; metal-binding site 1207075017300 homodimer binding site [polypeptide binding]; other site 1207075017301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1207075017302 carboxyltransferase (CT) interaction site; other site 1207075017303 biotinylation site [posttranslational modification]; other site 1207075017304 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1207075017305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1207075017306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1207075017307 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1207075017308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075017309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075017310 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1207075017311 putative dimerization interface [polypeptide binding]; other site 1207075017312 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1207075017313 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1207075017314 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1207075017315 putative active site [active] 1207075017316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075017317 PAS fold; Region: PAS_3; pfam08447 1207075017318 putative active site [active] 1207075017319 heme pocket [chemical binding]; other site 1207075017320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1207075017321 PAS domain; Region: PAS_9; pfam13426 1207075017322 putative active site [active] 1207075017323 heme pocket [chemical binding]; other site 1207075017324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1207075017325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1207075017326 metal binding site [ion binding]; metal-binding site 1207075017327 active site 1207075017328 I-site; other site 1207075017329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1207075017330 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1207075017331 Part of AAA domain; Region: AAA_19; pfam13245 1207075017332 Family description; Region: UvrD_C_2; pfam13538 1207075017333 Predicted membrane protein [Function unknown]; Region: COG2510 1207075017334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1207075017335 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1207075017336 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1207075017337 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1207075017338 pyridoxamine kinase; Validated; Region: PRK05756 1207075017339 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1207075017340 pyridoxal binding site [chemical binding]; other site 1207075017341 dimer interface [polypeptide binding]; other site 1207075017342 ATP binding site [chemical binding]; other site 1207075017343 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1207075017344 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1207075017345 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1207075017346 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1207075017347 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1207075017348 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1207075017349 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1207075017350 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1207075017351 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1207075017352 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1207075017353 trimer interface [polypeptide binding]; other site 1207075017354 active site 1207075017355 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1207075017356 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1207075017357 anticodon binding site; other site 1207075017358 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1207075017359 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1207075017360 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1207075017361 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1207075017362 putative active site [active] 1207075017363 catalytic site [active] 1207075017364 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1207075017365 putative active site [active] 1207075017366 catalytic site [active] 1207075017367 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1207075017368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075017369 S-adenosylmethionine binding site [chemical binding]; other site 1207075017370 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1207075017371 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1207075017372 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1207075017373 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1207075017374 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1207075017375 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1207075017376 HflC protein; Region: hflC; TIGR01932 1207075017377 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1207075017378 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 1207075017379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1207075017380 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1207075017381 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1207075017382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075017383 putative DNA binding site [nucleotide binding]; other site 1207075017384 putative Zn2+ binding site [ion binding]; other site 1207075017385 AsnC family; Region: AsnC_trans_reg; pfam01037 1207075017386 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1207075017387 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1207075017388 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1207075017389 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1207075017390 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1207075017391 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1207075017392 FAD binding pocket [chemical binding]; other site 1207075017393 FAD binding motif [chemical binding]; other site 1207075017394 phosphate binding motif [ion binding]; other site 1207075017395 beta-alpha-beta structure motif; other site 1207075017396 NAD binding pocket [chemical binding]; other site 1207075017397 Heme binding pocket [chemical binding]; other site 1207075017398 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1207075017399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1207075017400 catalytic loop [active] 1207075017401 iron binding site [ion binding]; other site 1207075017402 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1207075017403 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1207075017404 putative C-terminal domain interface [polypeptide binding]; other site 1207075017405 putative GSH binding site (G-site) [chemical binding]; other site 1207075017406 putative dimer interface [polypeptide binding]; other site 1207075017407 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1207075017408 putative N-terminal domain interface [polypeptide binding]; other site 1207075017409 putative dimer interface [polypeptide binding]; other site 1207075017410 putative substrate binding pocket (H-site) [chemical binding]; other site 1207075017411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1207075017412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1207075017413 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1207075017414 putative effector binding pocket; other site 1207075017415 putative dimerization interface [polypeptide binding]; other site 1207075017416 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1207075017417 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1207075017418 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1207075017419 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1207075017420 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1207075017421 HlyD family secretion protein; Region: HlyD_3; pfam13437 1207075017422 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1207075017423 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1207075017424 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1207075017425 glutaminase active site [active] 1207075017426 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1207075017427 dimer interface [polypeptide binding]; other site 1207075017428 active site 1207075017429 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1207075017430 dimer interface [polypeptide binding]; other site 1207075017431 active site 1207075017432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1207075017433 putative DNA binding site [nucleotide binding]; other site 1207075017434 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1207075017435 putative Zn2+ binding site [ion binding]; other site 1207075017436 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1207075017437 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1207075017438 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1207075017439 Substrate binding site; other site 1207075017440 Mg++ binding site; other site 1207075017441 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1207075017442 active site 1207075017443 substrate binding site [chemical binding]; other site 1207075017444 CoA binding site [chemical binding]; other site 1207075017445 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1207075017446 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1207075017447 gamma subunit interface [polypeptide binding]; other site 1207075017448 epsilon subunit interface [polypeptide binding]; other site 1207075017449 LBP interface [polypeptide binding]; other site 1207075017450 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1207075017451 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1207075017452 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1207075017453 alpha subunit interaction interface [polypeptide binding]; other site 1207075017454 Walker A motif; other site 1207075017455 ATP binding site [chemical binding]; other site 1207075017456 Walker B motif; other site 1207075017457 inhibitor binding site; inhibition site 1207075017458 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1207075017459 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1207075017460 core domain interface [polypeptide binding]; other site 1207075017461 delta subunit interface [polypeptide binding]; other site 1207075017462 epsilon subunit interface [polypeptide binding]; other site 1207075017463 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1207075017464 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1207075017465 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1207075017466 beta subunit interaction interface [polypeptide binding]; other site 1207075017467 Walker A motif; other site 1207075017468 ATP binding site [chemical binding]; other site 1207075017469 Walker B motif; other site 1207075017470 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1207075017471 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1207075017472 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1207075017473 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1207075017474 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1207075017475 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1207075017476 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1207075017477 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1207075017478 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1207075017479 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1207075017480 ParB-like nuclease domain; Region: ParBc; pfam02195 1207075017481 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1207075017482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075017483 P-loop; other site 1207075017484 Magnesium ion binding site [ion binding]; other site 1207075017485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1207075017486 Magnesium ion binding site [ion binding]; other site 1207075017487 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1207075017488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1207075017489 S-adenosylmethionine binding site [chemical binding]; other site 1207075017490 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1207075017491 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1207075017492 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1207075017493 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1207075017494 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1207075017495 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1207075017496 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1207075017497 G1 box; other site 1207075017498 GTP/Mg2+ binding site [chemical binding]; other site 1207075017499 Switch I region; other site 1207075017500 G2 box; other site 1207075017501 Switch II region; other site 1207075017502 G3 box; other site 1207075017503 G4 box; other site 1207075017504 G5 box; other site 1207075017505 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1207075017506 membrane protein insertase; Provisional; Region: PRK01318 1207075017507 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1207075017508 hypothetical protein; Provisional; Region: PRK14371 1207075017509 ribonuclease P; Reviewed; Region: rnpA; PRK00396 1207075017510 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399