-- dump date 20140620_013833 -- class Genbank::CDS -- table cds_note -- id note YP_001170551.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001170552.1 binds the polymerase to DNA and acts as a sliding clamp YP_001170553.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001170554.1 negatively supercoils closed circular double-stranded DNA YP_001170555.1 Code: O; COG: COG3634 YP_001170557.1 Code: I; COG: COG0204 YP_001170558.1 Code: E; COG: COG0241 YP_001170559.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001170560.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001170561.1 Code: L; COG: COG2818 YP_001170562.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001170563.1 Code: R; COG: COG0457 YP_001170564.1 Code: E; COG: COG1126 YP_001170565.1 Code: E; COG: COG0765 YP_001170566.1 Code: E; COG: COG0765 YP_001170567.1 Code: ET; COG: COG0834 YP_001170568.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001170569.1 Code: J; COG: COG0144 YP_001170570.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001170571.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001170572.1 Code: S; COG: COG1652 YP_001170573.1 Code: LU; COG: COG0758 YP_001170574.1 Code: J; COG: COG0009 YP_001170575.1 Code: CR; COG: COG0604 YP_001170576.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001170577.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001170579.1 Code: S; COG: COG4575 YP_001170580.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_001170581.1 Code: P; COG: COG1629 YP_001170583.1 Code: S; COG: COG4425 YP_001170586.1 Code: P; COG: COG1464 YP_001170587.1 Code: P; COG: COG2011 YP_001170588.1 part of the metNIQ transport system for methionine YP_001170589.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_001170590.1 Code: R; COG: COG1451 YP_001170591.1 Code: P; COG: COG1108 YP_001170592.1 Code: P; COG: COG1121 YP_001170593.1 Code: P; COG: COG0735 YP_001170594.1 Code: P; COG: COG4531 YP_001170595.1 catalyze the conversion of beta amino acids to the corresponding beta keto acid with pyruvate as the amine acceptor YP_001170597.1 Code: C; COG: COG1012 YP_001170598.1 Code: M; COG: COG1215 YP_001170602.1 Code: T; COG: COG3706 YP_001170603.1 Code: T; COG: COG0784 YP_001170605.1 Code: T; COG: COG0784 YP_001170607.1 Code: I; COG: COG1398 YP_001170608.1 Code: T; COG: COG2199 YP_001170610.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis YP_001170611.1 Code: R; COG: COG0388 YP_001170612.1 Code: K; COG: COG1309 YP_001170613.1 Code: E; COG: COG0174 YP_001170614.1 Code: R; COG: COG2071 YP_001170615.1 Code: E; COG: COG0174 YP_001170616.1 Code: H; COG: COG0161 YP_001170617.1 Code: E; COG: COG0687 YP_001170618.1 Code: E; COG: COG0687 YP_001170619.1 Code: E; COG: COG3842 YP_001170620.1 Code: E; COG: COG1176 YP_001170621.1 Code: E; COG: COG1177 YP_001170623.1 Code: I; COG: COG2267 YP_001170625.1 Code: O; COG: COG3751 YP_001170626.1 Code: G; COG: COG1593 YP_001170627.1 Code: G; COG: COG3090 YP_001170628.1 Code: G; COG: COG1638 YP_001170629.1 Code: T; COG: COG2204 YP_001170630.1 Code: T; COG: COG4191 YP_001170631.1 Code: M; COG: COG1091 YP_001170632.1 Code: M; COG: COG1898 YP_001170633.1 Code: M; COG: COG1209 YP_001170634.1 Code: M; COG: COG1088 YP_001170635.1 Code: V; COG: COG0842 YP_001170637.1 Code: M; COG: COG0845 YP_001170638.1 Code: R; COG: COG3218 YP_001170639.1 Code: Q; COG: COG1463 YP_001170640.1 Code: Q; COG: COG1127 YP_001170641.1 Code: Q; COG: COG0767 YP_001170644.1 Code: C; COG: COG3658 YP_001170645.1 Code: C; COG: COG1012 YP_001170646.1 Code: C; COG: COG3909 YP_001170647.1 Code: T; COG: COG1639 YP_001170649.1 Code: I; COG: COG1960 YP_001170650.1 Code: I; COG: COG1960 YP_001170651.1 Code: GEPR; COG: COG0477 YP_001170652.1 Code: R; COG: COG4757 YP_001170653.1 Code: K; COG: COG1309 YP_001170654.1 Code: K; COG: COG1414 YP_001170655.1 Code: IQ; COG: COG0318 YP_001170656.1 required for 70S ribosome assembly YP_001170657.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001170658.1 Code: F; COG: COG0209 YP_001170659.1 Code: F; COG: COG0209 YP_001170660.1 Code: R; COG: COG1611 YP_001170661.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_001170663.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001170668.1 Code: K; COG: COG2207 YP_001170669.1 Code: R; COG: COG0385 YP_001170670.1 Code: R; COG: COG2249 YP_001170671.1 Code: C; COG: COG1282 YP_001170672.1 Code: C; COG: COG3288 YP_001170673.1 Code: C; COG: COG3288 YP_001170674.1 Code: NU; COG: COG2804 YP_001170675.1 Code: NU; COG: COG1459 YP_001170676.1 Code: NU; COG: COG2165 YP_001170677.1 Code: NU; COG: COG2165 YP_001170678.1 Code: NU; COG: COG2165 YP_001170679.1 Code: U; COG: COG4795 YP_001170680.1 Code: U; COG: COG3156 YP_001170681.1 Code: U; COG: COG3297 YP_001170682.1 Code: U; COG: COG3149 YP_001170683.1 Code: T; COG: COG1639 YP_001170684.1 catalyzes branch migration in Holliday junction intermediates YP_001170685.1 Code: K; COG: COG0583 YP_001170686.1 Code: MG; COG: COG0451 YP_001170687.1 Code: ER; COG: COG1063 YP_001170689.1 Code: R; COG: COG0679 YP_001170690.1 Code: J; COG: COG2890 YP_001170692.1 Code: G; COG: COG2706 YP_001170693.1 Code: I; COG: COG1960 YP_001170695.1 Code: S; COG: COG3182 YP_001170696.1 Code: P; COG: COG1629 YP_001170698.1 Code: S; COG: COG3795 YP_001170699.1 Code: K; COG: COG4941 YP_001170700.1 Code: T; COG: COG2204 YP_001170701.1 Code: T; COG: COG4191 YP_001170702.1 Code: T; COG: COG2206 YP_001170703.1 Code: P; COG: COG0659 YP_001170704.1 Code: T; COG: COG0589 YP_001170705.1 Code: M; COG: COG2230 YP_001170706.1 Code: R; COG: COG2044 YP_001170707.1 Code: E; COG: COG0509 YP_001170709.1 Code: IQR; COG: COG1028 YP_001170710.1 Code: J; COG: COG3276 YP_001170711.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001170712.1 Code: O; COG: COG3058 YP_001170713.1 Code: C; COG: COG2864 YP_001170714.1 Code: C; COG: COG0437 YP_001170715.1 Code: C; COG: COG0243 YP_001170717.1 Code: K; COG: COG2207 YP_001170718.1 Code: O; COG: COG1764 YP_001170719.1 Code: R; COG: COG0596 YP_001170720.1 Code: S; COG: COG4395 YP_001170721.1 Code: Q; COG: COG4663 YP_001170722.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001170724.1 Code: O; COG: COG0826 YP_001170725.1 Code: S; COG: COG2841 YP_001170726.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP YP_001170728.2 N-acetyldiaminobutyrate dehydratase; catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha,gamma-diaminobutyric acid YP_001170729.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_001170730.1 Code: KR; COG: COG0454 YP_001170731.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001170732.1 Code: K; COG: COG1737 YP_001170734.1 Code: K; COG: COG0583 YP_001170735.1 biotin carboxylase; with subunit B, the carboxyltansferase/biotincarboxyl carrier subunit catalyzes the formation of oxaloacetate from pyruvate YP_001170736.1 catalyzes the formation of oxaloacetate from pyruvate YP_001170737.1 Code: R; COG: COG3329 YP_001170739.1 catalyzes the formation of glutamate from glutamine YP_001170740.1 Code: P; COG: COG0288 YP_001170741.1 Code: ET; COG: COG0834 YP_001170742.1 Code: EJ; COG: COG0252 YP_001170743.1 Code: E; COG: COG1115 YP_001170744.1 Code: K; COG: COG1396 YP_001170745.1 Code: C; COG: COG1301 YP_001170746.1 catalyzes the formation of fumarate from aspartate YP_001170747.1 Code: K; COG: COG0583 YP_001170749.1 Code: ER; COG: COG3185 YP_001170751.1 Code: F; COG: COG0041 YP_001170752.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001170753.1 Code: S; COG: COG2261 YP_001170754.1 Code: S; COG: COG3495 YP_001170755.1 Code: L; COG: COG1573 YP_001170756.1 Code: CHR; COG: COG1052 YP_001170757.1 Code: P; COG: COG1118 YP_001170758.1 Code: P; COG: COG4208 YP_001170759.1 Code: O; COG: COG0555 YP_001170760.1 Code: P; COG: COG1613 YP_001170761.1 Code: S; COG: COG5583 YP_001170762.1 Code: R; COG: COG3545 YP_001170763.1 Code: O; COG: COG0450 YP_001170765.1 Code: S; COG: COG3575 YP_001170767.1 Code: Q; COG: COG2015 YP_001170768.1 Code: K; COG: COG0583 YP_001170771.1 Code: K; COG: COG2207 YP_001170773.1 Code: L; COG: COG2801 YP_001170776.1 Code: L; COG: COG1961 YP_001170777.1 Code: P; COG: COG1230 YP_001170781.1 Code: OC; COG: COG0526 YP_001170782.1 Code: R; COG: COG0701 YP_001170783.1 Code: K; COG: COG1595 YP_001170784.1 Code: P; COG: COG0798 YP_001170785.1 Code: T; COG: COG0394 YP_001170786.1 Code: P; COG: COG0003 YP_001170789.1 Code: T; COG: COG0394 YP_001170790.1 Code: K; COG: COG0640 YP_001170791.1 Code: L; COG: COG1961 YP_001170793.1 Code: L; COG: COG4584 YP_001170794.1 Code: L; COG: COG1484 YP_001170797.1 Code: V; COG: COG0610 YP_001170800.1 Code: V; COG: COG0732 YP_001170801.1 Code: V; COG: COG0286 YP_001170805.1 Code: L; COG: COG2826 YP_001170808.1 Code: L; COG: COG0582 YP_001170810.1 Code: Q; COG: COG4664 YP_001170811.1 Code: Q; COG: COG4665 YP_001170812.1 Code: Q; COG: COG4663 YP_001170813.1 Code: O; COG: COG1764 YP_001170816.1 Code: S; COG: COG2989 YP_001170818.1 Code: NU; COG: COG2804 YP_001170819.1 Code: S; COG: COG3025 YP_001170820.1 Code: P; COG: COG1392 YP_001170821.1 Code: P; COG: COG0306 YP_001170822.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001170823.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001170824.1 involved in the first step of glutathione biosynthesis YP_001170825.1 Code: Q; COG: COG2050 YP_001170826.1 Code: K; COG: COG2183 YP_001170827.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_001170828.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001170829.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_001170830.1 Code: D; COG: COG1192 YP_001170833.1 Code: M; COG: COG0818 YP_001170834.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001170835.1 Code: T; COG: COG0642 YP_001170836.1 Code: HJ; COG: COG0189 YP_001170837.1 Code: O; COG: COG4067 YP_001170838.1 Code: J; COG: COG1188 YP_001170839.1 Code: I; COG: COG0671 YP_001170840.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001170841.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001170842.1 Code: C; COG: COG0778 YP_001170846.1 Code: NT; COG: COG0840 YP_001170847.1 Code: R; COG: COG0656 YP_001170848.1 Code: C; COG: COG3202 YP_001170853.1 Code: T; COG: COG0642 YP_001170857.1 Code: K; COG: COG0583 YP_001170858.1 Code: I; COG: COG1250 YP_001170859.1 Code: I; COG: COG1960 YP_001170860.1 Code: C; COG: COG1454 YP_001170861.1 Code: R; COG: COG0824 YP_001170863.1 Code: C; COG: COG1526 YP_001170865.1 Code: R; COG: COG1011 YP_001170866.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001170867.1 Code: P; COG: COG1218 YP_001170869.1 Code: R; COG: COG0727 YP_001170871.1 Code: G; COG: COG0058 YP_001170872.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001170873.1 Code: S; COG: COG3803 YP_001170875.1 Code: M; COG: COG3040 YP_001170877.1 Code: R; COG: COG0596 YP_001170878.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001170880.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001170881.1 Code: U; COG: COG0805 YP_001170882.1 Code: U; COG: COG1826 YP_001170883.1 Code: U; COG: COG1826 YP_001170884.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_001170885.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_001170886.1 Code: R; COG: COG0661 YP_001170887.1 Code: S; COG: COG3165 YP_001170888.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001170890.1 Code: NT; COG: COG0840 YP_001170891.1 Code: S; COG: COG3536 YP_001170892.1 heat shock protein involved in degradation of misfolded proteins YP_001170893.2 heat shock protein involved in degradation of misfolded proteins YP_001170894.1 Code: C; COG: COG0243 YP_001170895.1 Code: J; COG: COG0219 YP_001170897.1 Code: T; COG: COG2204 YP_001170898.1 Code: T; COG: COG3852 YP_001170901.1 Code: E; COG: COG0174 YP_001170902.1 Required for the synthesis of the thiazole moiety YP_001170903.1 Code: T; COG: COG1217 YP_001170904.1 Code: NT; COG: COG0840 YP_001170905.1 Code: C; COG: COG3493 YP_001170906.1 Code: T; COG: COG3290 YP_001170907.1 Code: KT; COG: COG4565 YP_001170908.1 Code: S; COG: COG4731 YP_001170909.1 Code: R; COG: COG0596 YP_001170912.1 Code: T; COG: COG2204 YP_001170913.1 Code: S; COG: COG4807 YP_001170914.1 Code: G; COG: COG2133 YP_001170916.1 Code: S; COG: COG3342 YP_001170919.1 Code: E; COG: COG0687 YP_001170920.1 Code: R; COG: COG1926 YP_001170923.1 Code: P; COG: COG0003 YP_001170925.1 Code: T; COG: COG1966 YP_001170926.1 Code: P; COG: COG1863 YP_001170927.1 Code: P; COG: COG2212 YP_001170928.1 Code: P; COG: COG1320 YP_001170930.1 Code: P; COG: COG1006 YP_001170932.1 Code: CP; COG: COG0651 YP_001170934.1 Code: NT; COG: COG0840 YP_001170936.1 Code: T; COG: COG0642 YP_001170937.1 Code: TK; COG: COG0745 YP_001170944.1 Code: R; COG: COG0628 YP_001170946.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001170947.1 Code: C; COG: COG0277 YP_001170948.1 Code: Q; COG: COG0179 YP_001170949.1 Code: S; COG: COG3204 YP_001170950.1 Code: S; COG: COG3204 YP_001170952.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001170953.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001170954.1 Code: S; COG: COG5528 YP_001170955.1 Code: GEPR; COG: COG0477 YP_001170956.1 Code: E; COG: COG0560 YP_001170957.1 hydrolyzes diadenosine polyphosphate YP_001170958.1 Code: T; COG: COG3605 YP_001170959.1 Code: S; COG: COG3332 YP_001170960.1 Code: R; COG: COG0730 YP_001170961.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001170962.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001170963.1 Code: D; COG: COG1192 YP_001170964.1 Code: E; COG: COG4177 YP_001170965.1 Code: E; COG: COG0559 YP_001170966.1 Code: E; COG: COG0410 YP_001170967.1 Code: E; COG: COG0411 YP_001170968.1 Code: E; COG: COG0683 YP_001170969.1 Code: T; COG: COG0589 YP_001170970.1 Code: T; COG: COG0784 YP_001170971.1 Code: M; COG: COG0739 YP_001170973.1 Code: R; COG: COG1253 YP_001170974.1 Code: T; COG: COG0642 YP_001170975.1 Code: TK; COG: COG0745 YP_001170976.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_001170977.1 Code: H; COG: COG3161 YP_001170978.1 Code: K; COG: COG2186 YP_001170979.1 Code: C; COG: COG0277 YP_001170980.1 Code: C; COG: COG0277 YP_001170981.1 Code: C; COG: COG0247 YP_001170982.1 Code: R; COG: COG3193 YP_001170983.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_001170984.1 Code: C; COG: COG1620 YP_001170985.1 Code: C; COG: COG1773 YP_001170986.1 Code: R; COG: COG0446 YP_001170987.1 Code: L; COG: COG0776 YP_001170989.1 Code: K; COG: COG0583 YP_001170990.1 Code: I; COG: COG1960 YP_001170991.1 Code: C; COG: COG1804 YP_001170992.1 Code: CR; COG: COG0604 YP_001170993.1 Code: K; COG: COG0583 YP_001170994.1 Code: S; COG: COG1704 YP_001170995.1 Code: R; COG: COG1512 YP_001170996.1 Code: S; COG: COG3762 YP_001170998.1 Code: K; COG: COG4977 YP_001171000.1 Code: ET; COG: COG0834 YP_001171001.1 Code: C; COG: COG2010 YP_001171002.1 Code: C; COG: COG1529 YP_001171003.1 Code: C; COG: COG2080 YP_001171006.1 Code: J; COG: COG0251 YP_001171007.1 Code: TK; COG: COG0317 YP_001171008.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001171009.1 Essential for recycling GMP and indirectly, cGMP YP_001171010.1 Code: S; COG: COG1561 YP_001171011.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001171012.1 Code: S; COG: COG3296 YP_001171013.1 Code: L; COG: COG0708 YP_001171014.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001171017.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001171019.1 catalyzes the formation of dUMP from dUTP YP_001171020.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001171021.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001171023.1 Code: Q; COG: COG2050 YP_001171024.1 Code: I; COG: COG1250 YP_001171025.1 Code: NT; COG: COG0840 YP_001171026.1 Code: S; COG: COG4539 YP_001171028.1 Code: I; COG: COG1502 YP_001171029.1 Code: E; COG: COG0665 YP_001171030.1 Code: K; COG: COG1522 YP_001171031.1 catalyzes the oxidative deamination of D-amino acids YP_001171032.1 Code: K; COG: COG1396 YP_001171033.1 Code: C; COG: COG3245 YP_001171034.1 Code: S; COG: COG4297 YP_001171035.1 Code: F; COG: COG0503 YP_001171037.1 Code: G; COG: COG0366 YP_001171038.1 Code: G; COG: COG0366 YP_001171039.1 Code: G; COG: COG0057 YP_001171040.1 Code: E; COG: COG3404 YP_001171041.1 Code: C; COG: COG1454 YP_001171042.1 Code: C; COG: COG1012 YP_001171044.1 Code: R; COG: COG1272 YP_001171045.1 Code: L; COG: COG0210 YP_001171047.1 Code: M; COG: COG1292 YP_001171048.1 Code: O; COG: COG0606 YP_001171050.1 Code: E; COG: COG0347 YP_001171051.1 Code: P; COG: COG0004 YP_001171052.1 Code: P; COG: COG0004 YP_001171053.1 Code: S; COG: COG0432 YP_001171055.1 Code: R; COG: COG1011 YP_001171056.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001171057.1 Code: S; COG: COG3159 YP_001171058.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001171059.1 Code: E; COG: COG0019 YP_001171060.1 Code: N; COG: COG5567 YP_001171061.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001171062.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001171064.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001171068.1 Code: P; COG: COG3213 YP_001171069.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001171070.1 Code: T; COG: COG2972 YP_001171071.1 Code: KT; COG: COG3279 YP_001171072.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001171073.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane YP_001171074.1 Code: H; COG: COG2959 YP_001171075.1 Code: H; COG: COG3071 YP_001171076.1 Code: O; COG: COG1495 YP_001171077.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_001171079.1 Code: S; COG: COG5589 YP_001171080.1 Code: R; COG: COG0488 YP_001171081.1 Code: M; COG: COG0668 YP_001171082.1 Code: P; COG: COG0861 YP_001171083.1 Code: E; COG: COG1280 YP_001171084.1 Code: S; COG: COG1671 YP_001171086.1 Code: Q; COG: COG2050 YP_001171087.1 Code: Q; COG: COG3155 YP_001171088.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001171089.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001171090.1 Code: FP; COG: COG0248 YP_001171091.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001171092.1 Code: H; COG: COG0043 YP_001171093.1 catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose YP_001171094.1 Code: D; COG: COG3087 YP_001171095.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001171096.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001171097.1 Code: L; COG: COG1525 YP_001171098.1 Code: C; COG: COG0281 YP_001171099.1 Code: M; COG: COG5009 YP_001171101.1 Code: NU; COG: COG4972 YP_001171102.1 Code: NU; COG: COG3166 YP_001171103.1 Code: NU; COG: COG3167 YP_001171104.1 Code: NU; COG: COG3168 YP_001171105.1 Code: U; COG: COG4796 YP_001171106.1 Code: E; COG: COG0703 YP_001171107.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001171109.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001171110.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001171111.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001171112.1 Code: GEPR; COG: COG0477 YP_001171113.1 Code: K; COG: COG0583 YP_001171115.1 Code: OC; COG: COG0526 YP_001171116.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_001171117.1 Code: P; COG: COG0471 YP_001171121.1 Code: L; COG: COG3666 YP_001171122.1 Code: P; COG: COG0798 YP_001171124.1 Code: O; COG: COG1495 YP_001171128.1 Code: L; COG: COG4584 YP_001171129.1 Code: L; COG: COG1484 YP_001171130.1 Code: L; COG: COG1643 YP_001171131.1 Code: L; COG: COG1643 YP_001171140.1 Code: K; COG: COG2378 YP_001171152.1 Code: IQ; COG: COG0318 YP_001171153.1 Code: IQR; COG: COG1028 YP_001171154.1 Code: I; COG: COG1960 YP_001171155.1 Code: I; COG: COG0183 YP_001171156.1 Code: I; COG: COG1024 YP_001171157.1 Code: C; COG: COG1012 YP_001171159.1 Code: C; COG: COG1804 YP_001171160.1 Code: E; COG: COG2303 YP_001171161.1 Code: K; COG: COG2207 YP_001171162.1 Code: Q; COG: COG2015 YP_001171165.1 Code: R; COG: COG4447 YP_001171166.1 Code: R; COG: COG1033 YP_001171171.1 Code: I; COG: COG1022 YP_001171173.1 Code: R; COG: COG3550 YP_001171180.1 Code: V; COG: COG0732 YP_001171181.1 Code: V; COG: COG0286 YP_001171183.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities YP_001171184.1 Code: L; COG: COG3436 YP_001171185.1 Code: L; COG: COG3436 YP_001171187.1 Code: V; COG: COG0610 YP_001171192.1 Code: L; COG: COG3436 YP_001171193.1 Code: L; COG: COG3436 YP_001171195.1 Code: V; COG: COG0286 YP_001171196.1 Code: L; COG: COG3436 YP_001171197.1 Code: L; COG: COG3436 YP_001171202.1 Code: L; COG: COG4584 YP_001171203.1 Code: L; COG: COG1484 YP_001171206.1 Code: L; COG: COG3344 YP_001171210.1 Code: O; COG: COG1651 YP_001171211.1 Code: K; COG: COG0789 YP_001171212.1 Code: P; COG: COG2217 YP_001171216.1 Code: L; COG: COG3666 YP_001171220.1 Code: L; COG: COG2963 YP_001171221.1 Code: L; COG: COG4584 YP_001171222.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001171223.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001171224.1 catalyzes the degradation of arginine to citruline and ammonia YP_001171225.1 Code: E; COG: COG0531 YP_001171227.1 Code: MU; COG: COG1538 YP_001171228.1 Code: V; COG: COG0842 YP_001171230.1 Code: M; COG: COG0845 YP_001171231.1 Code: I; COG: COG3243 YP_001171232.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001171233.1 Code: IQR; COG: COG1028 YP_001171234.1 Code: K; COG: COG2207 YP_001171235.1 Code: E; COG: COG0786 YP_001171236.1 Code: I; COG: COG0623 YP_001171237.1 Code: C; COG: COG0282 YP_001171238.1 catalyzes the formation of acetyl phosphate from acetyl-CoA and phosphate; can also act with other short-chain acyl-CoAs YP_001171241.1 Code: S; COG: COG5394 YP_001171245.1 Code: L; COG: COG2963 YP_001171246.1 Code: L; COG: COG2801 YP_001171256.1 Code: K; COG: COG1396 YP_001171259.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001171260.1 synthesizes RNA primers at the replication forks YP_001171261.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001171262.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001171263.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001171264.1 Code: H; COG: COG1539 YP_001171265.1 Code: H; COG: COG0801 YP_001171266.1 Code: J; COG: COG0617 YP_001171267.1 Code: S; COG: COG2719 YP_001171268.1 Code: S; COG: COG2718 YP_001171269.1 Code: T; COG: COG2766 YP_001171270.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_001171271.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001171272.1 protein associated with Co2+ and Mg2+ efflux YP_001171273.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001171274.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001171275.1 Code: O; COG: COG0760 YP_001171276.1 Code: M; COG: COG1452 YP_001171277.1 Code: R; COG: COG3178 YP_001171278.1 Code: MJ; COG: COG1208 YP_001171279.1 Code: O; COG: COG1076 YP_001171282.1 Code: TK; COG: COG2197 YP_001171283.1 Code: E; COG: COG3842 YP_001171284.1 Code: E; COG: COG0687 YP_001171285.1 Code: E; COG: COG1176 YP_001171286.1 Code: E; COG: COG1177 YP_001171287.1 Code: C; COG: COG1012 YP_001171288.1 Code: E; COG: COG0160 YP_001171289.1 Code: G; COG: COG0036 YP_001171290.1 Code: R; COG: COG0546 YP_001171291.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001171292.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_001171293.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001171294.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001171296.1 Code: O; COG: COG1765 YP_001171297.1 Code: H; COG: COG2941 YP_001171298.1 Code: O; COG: COG0464 YP_001171300.1 Code: S; COG: COG1981 YP_001171301.2 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001171302.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_001171303.1 distantly related to HSP70-fold metalloprotease; catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001171304.1 Code: M; COG: COG0739 YP_001171305.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001171306.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001171307.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001171309.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001171310.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001171311.1 Modulates Rho-dependent transcription termination YP_001171312.1 binds directly to 23S ribosomal RNA YP_001171313.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001171314.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001171315.1 Code: J; COG: COG0222 YP_001171316.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001171317.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001171318.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001171319.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001171320.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001171321.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001171322.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001171323.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001171324.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001171325.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001171326.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001171327.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001171328.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001171329.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001171330.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001171331.1 one of the stabilizing components for the large ribosomal subunit YP_001171332.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001171333.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001171334.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001171335.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001171336.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001171337.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001171338.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001171339.1 Code: J; COG: COG0256 YP_001171340.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001171341.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001171342.1 late assembly protein YP_001171343.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001171344.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001171345.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001171346.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001171347.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001171348.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001171349.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001171350.1 Code: P; COG: COG0753 YP_001171351.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001171352.1 Code: GEPR; COG: COG0477 YP_001171353.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_001171354.1 Code: M; COG: COG1091 YP_001171355.1 Code: MG; COG: COG0451 YP_001171356.1 Code: M; COG: COG3047 YP_001171359.1 Code: U; COG: COG0811 YP_001171360.1 Code: U; COG: COG0848 YP_001171363.1 Code: S; COG: COG3495 YP_001171364.1 Code: V; COG: COG0577 YP_001171365.1 Code: V; COG: COG1136 YP_001171368.1 Code: O; COG: COG3118 YP_001171369.1 Code: R; COG: COG2391 YP_001171371.1 Code: J; COG: COG1514 YP_001171373.1 Code: K; COG: COG1327 YP_001171374.1 Code: H; COG: COG1985 YP_001171375.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001171376.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis YP_001171377.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001171378.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001171379.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001171380.1 Code: I; COG: COG1267 YP_001171381.1 Code: R; COG: COG3577 YP_001171382.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001171384.1 Code: P; COG: COG0614 YP_001171385.1 Code: H; COG: COG4206 YP_001171386.1 Code: L; COG: COG0419 YP_001171387.1 Code: L; COG: COG0420 YP_001171388.1 Code: K; COG: COG2378 YP_001171389.1 Code: T; COG: COG0642 YP_001171390.1 Code: TK; COG: COG0745 YP_001171391.1 Code: S; COG: COG3212 YP_001171394.1 Code: S; COG: COG4312 YP_001171395.1 Code: S; COG: COG5591 YP_001171396.1 Code: J; COG: COG0564 YP_001171398.1 Catalyzes the formation of PRPP from ATP and ribose 5-phosphate YP_001171399.1 catalyzes the formation of thymine and 2-deoxy-alpha-D-ribose 1-phosphate from thymidine YP_001171400.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate YP_001171401.1 Code: GE; COG: COG2610 YP_001171402.1 Code: I; COG: COG2031 YP_001171403.1 Code: S; COG: COG1430 YP_001171404.1 Code: K; COG: COG1522 YP_001171405.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_001171406.1 Code: E; COG: COG0334 YP_001171407.1 Code: R; COG: COG0733 YP_001171408.1 Code: ER; COG: COG3185 YP_001171409.1 Code: Q; COG: COG3508 YP_001171410.1 Code: Q; COG: COG0179 YP_001171411.1 Code: O; COG: COG0625 YP_001171412.1 Code: R; COG: COG0733 YP_001171413.1 Code: NT; COG: COG0840 YP_001171414.1 Code: R; COG: COG0693 YP_001171415.1 Code: T; COG: COG2200 YP_001171416.1 Code: P; COG: COG0475 YP_001171417.1 Code: LKJ; COG: COG0513 YP_001171418.1 Code: E; COG: COG1280 YP_001171419.1 Code: K; COG: COG2207 YP_001171420.1 Code: R; COG: COG2081 YP_001171421.1 Code: BQ; COG: COG0123 YP_001171422.1 Code: J; COG: COG1670 YP_001171423.1 Code: I; COG: COG1946 YP_001171424.1 Code: R; COG: COG0546 YP_001171425.1 Code: R; COG: COG2321 YP_001171426.1 Code: R; COG: COG3019 YP_001171428.1 Code: T; COG: COG0664 YP_001171430.1 Code: TK; COG: COG2197 YP_001171431.1 Code: T; COG: COG3850 YP_001171432.1 Code: P; COG: COG2223 YP_001171434.1 Code: P; COG: COG2223 YP_001171435.1 Code: C; COG: COG5013 YP_001171436.1 Code: C; COG: COG1140 YP_001171437.1 Code: C; COG: COG2180 YP_001171438.1 Code: C; COG: COG2181 YP_001171439.1 Code: O; COG: COG0760 YP_001171440.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001171441.1 Code: H; COG: COG0521 YP_001171442.1 Code: H; COG: COG0303 YP_001171443.1 Code: C; COG: COG3038 YP_001171444.1 Code: T; COG: COG0642 YP_001171445.1 Code: TK; COG: COG0745 YP_001171447.1 Code: IQR; COG: COG1028 YP_001171449.1 Code: I; COG: COG1022 YP_001171451.1 Code: S; COG: COG3204 YP_001171452.1 Code: TK; COG: COG0745 YP_001171453.1 Code: T; COG: COG0642 YP_001171454.1 Code: QR; COG: COG0500 YP_001171456.1 Code: M; COG: COG0818 YP_001171457.1 Code: M; COG: COG1368 YP_001171458.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001171459.1 Code: R; COG: COG2252 YP_001171460.1 Code: R; COG: COG0693 YP_001171461.1 Code: O; COG: COG1975 YP_001171462.1 Code: R; COG: COG2068 YP_001171463.1 Code: C; COG: COG2080 YP_001171464.1 Code: C; COG: COG1319 YP_001171465.1 Code: C; COG: COG1529 YP_001171466.1 Code: I; COG: COG1835 YP_001171469.1 Code: S; COG: COG0599 YP_001171470.1 Code: K; COG: COG0789 YP_001171471.1 Code: J; COG: COG2813 YP_001171472.1 Code: C; COG: COG1018 YP_001171473.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001171474.1 Code: T; COG: COG2199 YP_001171478.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001171479.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001171480.1 Code: O; COG: COG2020 YP_001171482.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001171484.1 Code: S; COG: COG2841 YP_001171485.1 Code: M; COG: COG1970 YP_001171486.1 Code: P; COG: COG1858 YP_001171487.1 Code: O; COG: COG1067 YP_001171489.1 Code: S; COG: COG2862 YP_001171491.1 Code: R; COG: COG3046 YP_001171492.1 Code: O; COG: COG0545 YP_001171494.1 Code: H; COG: COG0142 YP_001171495.1 Code: J; COG: COG0261 YP_001171496.1 involved in the peptidyltransferase reaction during translation YP_001171497.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001171498.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001171499.1 Code: S; COG: COG3045 YP_001171500.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001171501.1 Code: R; COG: COG0728 YP_001171502.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001171503.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001171504.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001171505.1 Code: O; COG: COG1047 YP_001171506.1 Code: IM; COG: COG0761 YP_001171507.1 Code: NU; COG: COG4968 YP_001171509.1 Code: NU; COG: COG3419 YP_001171510.1 Code: NU; COG: COG4726 YP_001171511.1 Code: NU; COG: COG4966 YP_001171512.1 Code: NU; COG: COG4967 YP_001171513.1 Code: NU; COG: COG4970 YP_001171514.1 Code: NU; COG: COG4970 YP_001171515.1 Code: E; COG: COG0665 YP_001171516.1 Code: J; COG: COG0023 YP_001171517.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_001171518.1 Code: S; COG: COG3556 YP_001171519.1 Code: V; COG: COG0534 YP_001171521.1 Code: S; COG: COG3204 YP_001171522.1 Code: S; COG: COG3238 YP_001171525.1 Code: QR; COG: COG0500 YP_001171526.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001171528.1 Code: G; COG: COG1105 YP_001171530.1 Code: G; COG: COG4993 YP_001171531.1 Code: S; COG: COG2852 YP_001171532.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001171533.1 Code: E; COG: COG0019 YP_001171534.1 Code: S; COG: COG3128 YP_001171535.1 Code: P; COG: COG4774 YP_001171536.1 Code: P; COG: COG0369 YP_001171538.1 Code: S; COG: COG3656 YP_001171539.1 Code: S; COG: COG3295 YP_001171540.1 Code: P; COG: COG4771 YP_001171541.1 Code: S; COG: COG3471 YP_001171542.1 Code: T; COG: COG0642 YP_001171543.1 Code: TK; COG: COG4567 YP_001171544.1 Code: R; COG: COG0679 YP_001171545.1 Code: M; COG: COG0739 YP_001171547.1 Code: M; COG: COG1664 YP_001171548.1 Code: P; COG: COG0530 YP_001171549.1 Code: P; COG: COG0530 YP_001171550.1 Code: M; COG: COG0797 YP_001171551.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001171552.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001171553.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001171554.1 functions in MreBCD complex in some organisms YP_001171555.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001171556.1 Code: M; COG: COG2891 YP_001171558.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001171559.1 Code: J; COG: COG1530 YP_001171560.1 Code: S; COG: COG3164 YP_001171561.1 Code: R; COG: COG0388 YP_001171562.1 Code: R; COG: COG0312 YP_001171563.1 Code: S; COG: COG3028 YP_001171565.1 Code: R; COG: COG0312 YP_001171566.1 Code: G; COG: COG1925 YP_001171567.1 Code: R; COG: COG1660 YP_001171568.1 Code: GT; COG: COG1762 YP_001171569.1 Code: J; COG: COG1544 YP_001171570.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_001171571.1 Code: R; COG: COG1137 YP_001171572.1 Code: S; COG: COG1934 YP_001171573.1 Code: S; COG: COG3117 YP_001171574.1 Code: R; COG: COG1778 YP_001171575.1 Code: M; COG: COG0794 YP_001171576.1 Code: Q; COG: COG1127 YP_001171577.1 Code: Q; COG: COG0767 YP_001171578.1 Code: Q; COG: COG1463 YP_001171579.1 Code: Q; COG: COG2854 YP_001171580.1 Code: T; COG: COG1366 YP_001171581.1 Code: S; COG: COG3223 YP_001171582.1 Code: K; COG: COG5007 YP_001171583.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001171584.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_001171585.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001171586.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001171587.1 Code: O; COG: COG0265 YP_001171588.1 Code: S; COG: COG0327 YP_001171589.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001171590.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_001171591.1 Code: L; COG: COG1943 YP_001171593.1 Code: NU; COG: COG4969 YP_001171594.1 Code: NU; COG: COG2804 YP_001171595.1 Code: NU; COG: COG1459 YP_001171596.1 Code: NOU; COG: COG1989 YP_001171597.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001171598.1 Code: S; COG: COG3235 YP_001171599.1 Code: C; COG: COG0667 YP_001171600.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001171601.1 forms a direct contact with the tRNA during translation YP_001171602.1 Code: C; COG: COG0723 YP_001171603.1 Code: C; COG: COG1290 YP_001171604.1 Code: C; COG: COG2857 YP_001171605.1 Code: O; COG: COG0625 YP_001171606.1 Code: R; COG: COG2969 YP_001171607.1 Code: R; COG: COG2823 YP_001171608.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001171609.1 distantly related to archaeal Holliday junction resolvase; Code: L; COG: COG0792 YP_001171610.1 Code: R; COG: COG3107 YP_001171611.1 Code: R; COG: COG0313 YP_001171612.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001171613.1 Code: M; COG: COG0275 YP_001171614.1 Code: D; COG: COG3116 YP_001171615.1 Code: M; COG: COG0768 YP_001171616.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001171617.1 Code: M; COG: COG0770 YP_001171618.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001171619.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001171620.1 Code: D; COG: COG0772 YP_001171621.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001171622.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001171623.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001171624.1 Code: M; COG: COG1589 YP_001171625.1 Code: D; COG: COG0849 YP_001171626.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001171627.2 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001171628.1 Code: L; COG: COG3464 YP_001171629.1 Code: P; COG: COG2193 YP_001171630.1 Code: R; COG: COG3668 YP_001171631.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_001171632.1 Code: G; COG: COG2133 YP_001171633.1 Code: S; COG: COG1285 YP_001171635.1 Code: S; COG: COG4875 YP_001171637.1 Code: R; COG: COG1611 YP_001171638.1 Code: IQR; COG: COG1028 YP_001171639.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001171641.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001171649.1 Code: S; COG: COG2135 YP_001171650.1 Code: O; COG: COG0501 YP_001171652.1 Code: S; COG: COG2119 YP_001171653.1 Code: J; COG: COG2813 YP_001171654.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor YP_001171655.1 Code: E; COG: COG1280 YP_001171656.1 activates fatty acids by binding to coenzyme A YP_001171658.1 Code: R; COG: COG0491 YP_001171659.1 Code: M; COG: COG2885 YP_001171662.1 Code: I; COG: COG0204 YP_001171663.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001171664.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001171665.1 Code: O; COG: COG1047 YP_001171666.1 Code: O; COG: COG0386 YP_001171667.1 Code: K; COG: COG1309 YP_001171668.1 Code: C; COG: COG1902 YP_001171669.1 putative role in sulfur assimilation YP_001171671.1 Code: S; COG: COG3492 YP_001171672.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_001171673.1 Code: IQR; COG: COG1028 YP_001171675.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001171676.1 Code: G; COG: COG0235 YP_001171677.1 Code: S; COG: COG3124 YP_001171678.1 Code: I; COG: COG0204 YP_001171679.1 Code: R; COG: COG3176 YP_001171680.1 Code: I; COG: COG1960 YP_001171681.1 Code: I; COG: COG1502 YP_001171682.1 Code: R; COG: COG0693 YP_001171683.1 Code: S; COG: COG4628 YP_001171684.1 Code: C; COG: COG1951 YP_001171685.1 Code: T; COG: COG2199 YP_001171686.1 Code: HC; COG: COG0543 YP_001171687.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001171691.1 Code: R; COG: COG1721 YP_001171692.1 Code: R; COG: COG0714 YP_001171695.1 Code: S; COG: COG1300 YP_001171696.1 Code: S; COG: COG1714 YP_001171697.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001171700.1 Code: L; COG: COG3344 YP_001171702.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001171704.1 Code: R; COG: COG0433 YP_001171706.1 Code: M; COG: COG0836 YP_001171707.1 Code: S; COG: COG3022 YP_001171708.1 Code: P; COG: COG1230 YP_001171709.1 Code: T; COG: COG1875 YP_001171710.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001171711.1 Code: H; COG: COG1977 YP_001171712.1 Code: H; COG: COG0314 YP_001171714.2 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001171715.1 Code: R; COG: COG0400 YP_001171717.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001171719.1 Code: S; COG: COG3034 YP_001171720.1 Code: F; COG: COG1051 YP_001171721.1 Code: LR; COG: COG0494 YP_001171722.1 Code: R; COG: COG0663 YP_001171723.1 Code: R; COG: COG3313 YP_001171724.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001171725.1 Code: P; COG: COG4536 YP_001171726.1 Code: R; COG: COG4137 YP_001171727.1 Code: U; COG: COG0541 YP_001171728.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001171729.1 Essential for efficient processing of 16S rRNA YP_001171730.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001171731.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001171732.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001171733.1 Code: O; COG: COG1651 YP_001171734.1 Code: S; COG: COG3791 YP_001171735.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001171736.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001171737.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001171738.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001171739.1 Code: M; COG: COG2885 YP_001171740.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001171741.1 Code: E; COG: COG0346 YP_001171743.1 Code: L; COG: COG0177 YP_001171744.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001171745.1 Code: C; COG: COG4659 YP_001171746.1 Code: C; COG: COG4658 YP_001171747.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001171748.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001171749.1 Code: C; COG: COG4657 YP_001171750.1 Code: I; COG: COG1024 YP_001171751.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001171753.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001171754.1 Code: S; COG: COG3652 YP_001171755.1 Code: T; COG: COG1639 YP_001171756.1 related to GcvT; Code: R; COG: COG0354 YP_001171757.1 Code: S; COG: COG2938 YP_001171759.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001171760.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates genes involved in alginate biosynthesis YP_001171761.1 Code: T; COG: COG3073 YP_001171762.1 Code: T; COG: COG3026 YP_001171763.1 Code: T; COG: COG3086 YP_001171764.1 Code: O; COG: COG0265 YP_001171765.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001171766.1 Code: U; COG: COG0681 YP_001171768.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001171769.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001171770.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001171771.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001171773.1 Code: K; COG: COG0583 YP_001171774.1 Code: QR; COG: COG0500 YP_001171775.1 Code: QR; COG: COG0500 YP_001171776.1 Code: S; COG: COG5513 YP_001171777.1 Code: O; COG: COG0466 YP_001171778.1 Code: K; COG: COG2207 YP_001171779.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_001171780.1 Code: ER; COG: COG0591 YP_001171782.1 Code: P; COG: COG1629 YP_001171783.1 Code: ER; COG: COG0591 YP_001171785.1 Code: K; COG: COG0583 YP_001171786.1 Code: Q; COG: COG3485 YP_001171787.1 Code: Q; COG: COG3485 YP_001171788.1 Code: R; COG: COG1485 YP_001171790.1 Code: K; COG: COG1414 YP_001171791.1 Code: I; COG: COG1788 YP_001171792.1 Code: I; COG: COG2057 YP_001171793.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_001171794.1 Catalyzes the cycloisomerization of cis,cis-muconate YP_001171795.1 Code: R; COG: COG0596 YP_001171796.1 Code: S; COG: COG0599 YP_001171797.1 Code: J; COG: COG1187 YP_001171798.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001171799.1 Code: D; COG: COG0489 YP_001171800.1 Code: K; COG: COG1278 YP_001171801.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001171802.1 Code: C; COG: COG3005 YP_001171803.1 Code: C; COG: COG3043 YP_001171804.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001171805.1 Code: P; COG: COG3062 YP_001171806.1 Code: C; COG: COG4459 YP_001171807.1 Code: GEPR; COG: COG0477 YP_001171808.1 Code: S; COG: COG3091 YP_001171811.1 Code: O; COG: COG2214 YP_001171812.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001171813.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001171814.1 Code: L; COG: COG2818 YP_001171817.1 Code: C; COG: COG1271 YP_001171818.1 Code: C; COG: COG1294 YP_001171820.1 Code: S; COG: COG4890 YP_001171821.1 Code: M; COG: COG0791 YP_001171822.1 Code: M; COG: COG0791 YP_001171824.1 Code: R; COG: COG1409 YP_001171825.1 Code: H; COG: COG4206 YP_001171827.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001171828.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001171829.1 Code: C; COG: COG0778 YP_001171831.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_001171832.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_001171833.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001171834.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_001171835.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_001171836.1 Code: G; COG: COG0406 YP_001171837.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_001171838.1 Code: O; COG: COG0278 YP_001171839.1 Code: P; COG: COG0607 YP_001171843.1 Code: R; COG: COG0535 YP_001171844.1 Code: S; COG: COG3865 YP_001171845.1 Code: K; COG: COG0583 YP_001171846.1 Code: J; COG: COG0251 YP_001171847.1 Code: K; COG: COG2207 YP_001171848.1 Code: GEPR; COG: COG0477 YP_001171849.1 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide YP_001171850.1 Code: KT; COG: COG3604 YP_001171852.1 Code: C; COG: COG4657 YP_001171853.1 Code: C; COG: COG2878 YP_001171854.1 Code: C; COG: COG4656 YP_001171855.1 Code: C; COG: COG4658 YP_001171856.1 Code: C; COG: COG4659 YP_001171857.1 Code: C; COG: COG4660 YP_001171858.1 Code: S; COG: COG2914 YP_001171863.1 Code: P; COG: COG1348 YP_001171864.1 Code: C; COG: COG2710 YP_001171865.1 Code: C; COG: COG2710 YP_001171866.1 Code: Q; COG: COG5554 YP_001171870.1 Code: C; COG: COG2710 YP_001171871.1 functions with NifE to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe YP_001171875.1 Code: C; COG: COG1145 YP_001171876.1 Code: C; COG: COG3411 YP_001171882.1 Code: P; COG: COG4148 YP_001171883.1 Code: P; COG: COG4149 YP_001171884.1 Code: P; COG: COG0725 YP_001171885.1 Code: R; COG: COG2005 YP_001171886.1 Code: S; COG: COG0316 YP_001171888.1 Code: E; COG: COG1104 YP_001171889.1 Code: E; COG: COG0119 YP_001171890.1 Code: E; COG: COG1045 YP_001171895.1 binds and unfolds substrates as part of the ClpXP protease YP_001171896.1 Code: C; COG: COG0716 YP_001171897.1 Code: O; COG: COG0386 YP_001171898.1 Code: I; COG: COG2067 YP_001171899.1 Code: P; COG: COG2897 YP_001171900.1 Code: J; COG: COG0349 YP_001171901.1 Code: S; COG: COG3100 YP_001171903.1 Code: S; COG: COG2983 YP_001171905.1 Code: E; COG: COG2008 YP_001171906.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001171907.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001171908.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001171910.1 Code: P; COG: COG2239 YP_001171911.1 catalyzes the formation of pyruvate from oxaloacetate YP_001171912.1 Code: C; COG: COG1883 YP_001171915.1 Code: M; COG: COG5581 YP_001171917.1 Code: KNU; COG: COG2747 YP_001171918.1 required for the assembly of the flagellar basal body P-ring YP_001171920.1 Code: NT; COG: COG1352 YP_001171921.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001171922.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001171923.1 Code: N; COG: COG1843 YP_001171924.1 the hook connects flagellar basal body to the flagellar filament YP_001171925.1 Code: N; COG: COG4787 YP_001171926.1 makes up the distal portion of the flagellar basal body rod YP_001171927.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001171928.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001171929.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_001171930.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001171931.1 With FlgK acts as a hook filament junction protein to join the flagellar filament to the hook YP_001171933.1 Code: P; COG: COG0529 YP_001171937.1 Code: N; COG: COG1344 YP_001171938.1 Code: N; COG: COG1334 YP_001171939.1 Code: N; COG: COG1345 YP_001171940.1 Code: L; COG: COG1555 YP_001171941.1 Code: S; COG: COG3339 YP_001171942.1 Code: K; COG: COG1396 YP_001171946.1 Code: M; COG: COG0793 YP_001171947.1 Code: CR; COG: COG0604 YP_001171948.1 Code: S; COG: COG4924 YP_001171949.1 Code: S; COG: COG2361 YP_001171950.1 Code: R; COG: COG1669 YP_001171951.1 Code: S; COG: COG4913 YP_001171954.1 catalyzes the removal of amino acids from the N termini of peptides YP_001171955.1 Code: J; COG: COG0564 YP_001171956.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001171957.1 Code: D; COG: COG2894 YP_001171958.1 blocks the formation of polar Z-ring septums YP_001171959.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001171960.1 Code: R; COG: COG1741 YP_001171961.1 Code: M; COG: COG2853 YP_001171963.1 Code: S; COG: COG3205 YP_001171964.1 Code: S; COG: COG3162 YP_001171965.1 Code: R; COG: COG4147 YP_001171966.1 Code: IQR; COG: COG1028 YP_001171967.1 Code: P; COG: COG2807 YP_001171969.1 Code: S; COG: COG3089 YP_001171971.1 Code: G; COG: COG1363 YP_001171973.1 Code: E; COG: COG0367 YP_001171974.1 Code: K; COG: COG1846 YP_001171975.1 Code: O; COG: COG1404 YP_001171976.1 Code: S; COG: COG4301 YP_001171977.1 Code: S; COG: COG1262 YP_001171979.1 Code: R; COG: COG4221 YP_001171981.1 Code: R; COG: COG1201 YP_001171985.1 Code: J; COG: COG1187 YP_001171987.1 Code: G; COG: COG2133 YP_001171988.1 Code: G; COG: COG4993 YP_001171989.1 Code: S; COG: COG2996 YP_001171990.1 Code: S; COG: COG5483 YP_001171999.1 Code: V; COG: COG4096 YP_001172001.1 Code: V; COG: COG0286 YP_001172006.1 Code: N; COG: COG1360 YP_001172009.1 Code: L; COG: COG1484 YP_001172010.1 Code: L; COG: COG4584 YP_001172012.1 Code: KL; COG: COG0553 YP_001172017.1 Code: S; COG: COG4643 YP_001172018.1 Code: L; COG: COG2801 YP_001172019.1 Code: L; COG: COG2963 YP_001172022.1 Code: GEPR; COG: COG0477 YP_001172023.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_001172024.1 Code: T; COG: COG2199 YP_001172026.1 Code: S; COG: COG1295 YP_001172027.1 Code: M; COG: COG0438 YP_001172028.1 Code: R; COG: COG3233 YP_001172029.1 Code: S; COG: COG0392 YP_001172030.1 Code: S; COG: COG3237 YP_001172031.1 Code: C; COG: COG1146 YP_001172032.1 This protein performs the mismatch recognition step during the DNA repair process YP_001172034.1 Code: R; COG: COG1546 YP_001172035.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001172036.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001172037.1 Code: R; COG: COG1611 YP_001172038.1 Code: J; COG: COG1236 YP_001172039.1 Code: G; COG: COG3957 YP_001172041.1 Code: S; COG: COG3148 YP_001172042.1 Code: GER; COG: COG0697 YP_001172043.1 Code: TK; COG: COG2197 YP_001172044.1 Code: K; COG: COG0583 YP_001172045.1 Code: C; COG: COG1018 YP_001172046.1 Code: S; COG: COG3012 YP_001172048.1 Code: M; COG: COG2885 YP_001172049.1 Code: S; COG: COG5615 YP_001172050.1 helicase involved in DNA repair and perhaps also replication YP_001172051.1 Code: V; COG: COG1680 YP_001172053.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001172055.1 Code: M; COG: COG3133 YP_001172056.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_001172057.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001172058.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001172059.1 Code: P; COG: COG1863 YP_001172060.1 Code: P; COG: COG2212 YP_001172061.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001172062.1 Catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001172063.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001172064.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001172065.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001172066.1 Catalyzes the phosphorylation of UMP to UDP YP_001172067.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001172068.1 Code: I; COG: COG0020 YP_001172069.1 Code: I; COG: COG0575 YP_001172070.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001172071.1 Code: M; COG: COG0750 YP_001172072.1 Code: M; COG: COG4775 YP_001172073.1 Code: M; COG: COG2825 YP_001172074.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001172075.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001172076.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001172077.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001172078.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001172079.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001172080.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001172081.1 Code: D; COG: COG0037 YP_001172082.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001172083.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001172084.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001172085.1 Code: D; COG: COG2919 YP_001172086.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001172089.1 Code: K; COG: COG0583 YP_001172090.1 Code: C; COG: COG1062 YP_001172091.1 Code: R; COG: COG0627 YP_001172092.1 Code: C; COG: COG1902 YP_001172093.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001172094.1 catalyzes the modification of U13 in tRNA(Glu) YP_001172095.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001172096.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_001172097.1 Code: S; COG: COG2035 YP_001172098.1 Code: M; COG: COG0739 YP_001172099.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_001172105.1 Code: F; COG: COG0127 YP_001172106.1 Code: R; COG: COG2346 YP_001172107.1 Code: T; COG: COG0589 YP_001172109.1 Code: S; COG: COG0217 YP_001172110.1 Code: L; COG: COG2826 YP_001172111.1 Code: GER; COG: COG0697 YP_001172113.1 Code: S; COG: COG2258 YP_001172115.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_001172116.1 Code: P; COG: COG0004 YP_001172117.1 Code: HE; COG: COG0111 YP_001172120.1 Code: G; COG: COG0483 YP_001172124.1 Code: NT; COG: COG0840 YP_001172125.1 Code: O; COG: COG0760 YP_001172126.1 Code: P; COG: COG0226 YP_001172127.1 Code: P; COG: COG1283 YP_001172128.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001172129.1 Code: KG; COG: COG1349 YP_001172130.1 Code: C; COG: COG0554 YP_001172131.1 Code: G; COG: COG0580 YP_001172134.1 Code: P; COG: COG1226 YP_001172135.1 Code: S; COG: COG1801 YP_001172137.1 Code: E; COG: COG1231 YP_001172138.1 Code: C; COG: COG2010 YP_001172139.1 Code: J; COG: COG0251 YP_001172140.1 Code: G; COG: COG2814 YP_001172141.1 Code: O; COG: COG0826 YP_001172144.1 Code: S; COG: COG2340 YP_001172146.1 Code: P; COG: COG1230 YP_001172147.1 Code: K; COG: COG0789 YP_001172148.1 Code: G; COG: COG3386 YP_001172151.1 Code: K; COG: COG0583 YP_001172152.1 Code: R; COG: COG2249 YP_001172155.1 Code: S; COG: COG4704 YP_001172156.1 Code: P; COG: COG0376 YP_001172157.1 Code: QR; COG: COG0500 YP_001172159.1 Code: K; COG: COG0583 YP_001172163.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001172164.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001172165.1 Code: TK; COG: COG0745 YP_001172166.1 Code: T; COG: COG0642 YP_001172167.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001172168.1 Code: M; COG: COG0668 YP_001172169.1 Code: P; COG: COG0607 YP_001172172.1 Code: S; COG: COG5579 YP_001172173.1 Code: T; COG: COG2206 YP_001172174.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001172175.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001172177.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_001172178.1 Code: V; COG: COG1131 YP_001172179.1 Code: V; COG: COG0842 YP_001172180.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001172182.1 Code: M; COG: COG2853 YP_001172185.1 Code: T; COG: COG1366 YP_001172186.1 Code: G; COG: COG0176 YP_001172187.1 Code: J; COG: COG0042 YP_001172188.1 Code: G; COG: COG1593 YP_001172190.1 Code: G; COG: COG1638 YP_001172192.1 Code: K; COG: COG2207 YP_001172193.1 Code: PR; COG: COG4638 YP_001172194.1 Code: Q; COG: COG5517 YP_001172195.1 Code: HC; COG: COG0543 YP_001172196.1 catalyzes the degradation of 2-hydro-1,2-dihydroxy benzoate to catechol YP_001172197.1 Code: GEPR; COG: COG0477 YP_001172198.1 Code: MR; COG: COG4948 YP_001172199.1 Code: Q; COG: COG4829 YP_001172200.1 Code: Q; COG: COG3485 YP_001172201.1 Code: Q; COG: COG3135 YP_001172204.1 Code: C; COG: COG1249 YP_001172205.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001172206.1 Code: S; COG: COG3184 YP_001172207.1 Code: R; COG: COG1054 YP_001172208.1 Code: O; COG: COG3531 YP_001172209.1 Code: V; COG: COG1132 YP_001172210.1 Code: NT; COG: COG0840 YP_001172211.1 Code: R; COG: COG1988 YP_001172212.1 Code: J; COG: COG1186 YP_001172213.1 Code: GEPR; COG: COG0477 YP_001172215.1 Code: S; COG: COG3777 YP_001172216.1 Code: I; COG: COG1960 YP_001172217.1 Code: E; COG: COG0346 YP_001172218.1 Code: R; COG: COG2079 YP_001172219.1 Code: C; COG: COG1804 YP_001172220.1 Code: G; COG: COG2301 YP_001172221.1 Code: G; COG: COG1638 YP_001172224.1 Code: L; COG: COG2801 YP_001172225.1 Code: L; COG: COG2801 YP_001172226.1 Code: L; COG: COG3344 YP_001172228.1 Code: R; COG: COG4172 YP_001172229.1 Code: R; COG: COG4239 YP_001172230.1 Code: R; COG: COG4174 YP_001172231.1 Code: E; COG: COG4166 YP_001172232.1 Code: P; COG: COG1629 YP_001172233.1 Code: U; COG: COG0848 YP_001172234.1 Code: U; COG: COG0811 YP_001172235.1 Code: M; COG: COG0810 YP_001172236.1 Code: R; COG: COG0312 YP_001172237.1 Code: R; COG: COG0312 YP_001172238.1 Code: E; COG: COG0119 YP_001172239.1 Code: C; COG: COG1804 YP_001172240.1 Code: K; COG: COG0583 YP_001172242.1 Code: G; COG: COG1638 YP_001172243.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001172245.1 Code: E; COG: COG1770 YP_001172246.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001172247.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001172248.1 Code: S; COG: COG4728 YP_001172249.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001172251.1 Code: GER; COG: COG0697 YP_001172253.1 Code: D; COG: COG5404 YP_001172254.1 Code: KT; COG: COG1974 YP_001172255.1 Code: K; COG: COG1309 YP_001172257.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001172258.1 Catalyzes the phosphorolytic cleavage of 6-oxopurine nucleosides YP_001172259.1 Code: S; COG: COG5608 YP_001172261.1 Code: R; COG: COG2366 YP_001172262.1 Code: S; COG: COG1720 YP_001172263.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001172264.1 proton-motive-force-driven choline transporter YP_001172265.1 catalyzes the formation of betaine from betaine aldehyde YP_001172266.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_001172267.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001172268.1 Code: I; COG: COG1835 YP_001172271.1 Code: M; COG: COG0438 YP_001172273.1 Code: M; COG: COG0438 YP_001172277.1 Code: K; COG: COG0250 YP_001172279.1 Code: M; COG: COG3206 YP_001172280.1 Code: M; COG: COG0463 YP_001172282.1 Code: M; COG: COG0399 YP_001172286.1 Code: J; COG: COG0042 YP_001172287.1 Code: IQR; COG: COG1028 YP_001172288.1 Code: O; COG: COG0071 YP_001172289.1 Code: K; COG: COG0583 YP_001172290.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001172291.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001172292.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001172293.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001172294.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001172295.1 Code: NU; COG: COG3170 YP_001172296.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001172297.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_001172298.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001172299.1 Code: H; COG: COG0285 YP_001172300.1 Code: S; COG: COG3147 YP_001172301.1 Code: R; COG: COG1286 YP_001172302.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001172303.1 catalyzes the conversion of O-succinylhomoserine into homocysteine YP_001172304.1 Code: NU; COG: COG1450 YP_001172307.1 Code: K; COG: COG0789 YP_001172308.1 Code: E; COG: COG1280 YP_001172310.1 Code: S; COG: COG4744 YP_001172311.1 Code: U; COG: COG0811 YP_001172312.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_001172313.1 Code: P; COG: COG4771 YP_001172314.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001172315.1 Code: E; COG: COG2008 YP_001172316.1 Code: K; COG: COG0583 YP_001172317.1 stationary phase protein that binds TrpR repressor YP_001172318.1 Code: GEPR; COG: COG0477 YP_001172319.1 Code: G; COG: COG2513 YP_001172322.1 Code: E; COG: COG3227 YP_001172323.1 Code: C; COG: COG1271 YP_001172324.1 Code: C; COG: COG1294 YP_001172326.1 Code: K; COG: COG2207 YP_001172327.1 Code: R; COG: COG0388 YP_001172331.1 Code: E; COG: COG2515 YP_001172333.1 Code: V; COG: COG0534 YP_001172334.1 Required for the de novo synthesis of pyroxidine via the pdxA branch; catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate YP_001172335.1 Code: L; COG: COG3344 YP_001172336.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001172337.1 Code: S; COG: COG0718 YP_001172338.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001172340.1 Code: P; COG: COG1116 YP_001172341.1 Code: P; COG: COG0600 YP_001172343.1 Code: R; COG: COG1999 YP_001172344.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001172345.1 Code: T; COG: COG0664 YP_001172346.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001172347.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001172348.1 Code: S; COG: COG2836 YP_001172349.1 Code: P; COG: COG3197 YP_001172350.1 Code: P; COG: COG2217 YP_001172351.1 Code: S; COG: COG3198 YP_001172352.1 Code: C; COG: COG0348 YP_001172353.1 Code: C; COG: COG2010 YP_001172354.1 Code: O; COG: COG4736 YP_001172355.1 CcoO; FixO YP_001172356.1 CcoN; FixN YP_001172357.1 Code: C; COG: COG2010 YP_001172358.1 CcoO; FixO YP_001172359.1 Code: O; COG: COG3278 YP_001172360.1 Code: R; COG: COG3571 YP_001172361.1 Code: NT; COG: COG0840 YP_001172362.1 Code: C; COG: COG1048 YP_001172363.2 Code: R; COG: COG2933 YP_001172364.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_001172366.1 Code: C; COG: COG0843 YP_001172368.1 Code: S; COG: COG1981 YP_001172369.1 Code: P; COG: COG1226 YP_001172370.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001172371.1 Code: D; COG: COG1196 YP_001172372.1 interacts directly with the cell division protein ftsZ; probable receptor for the septal ring structure, may anchor it to the inner-membrane YP_001172373.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001172375.1 Code: L; COG: COG2801 YP_001172376.1 Code: L; COG: COG2963 YP_001172377.1 Code: N; COG: COG1344 YP_001172378.1 Code: N; COG: COG1334 YP_001172379.1 Code: N; COG: COG1345 YP_001172380.1 Code: L; COG: COG2801 YP_001172381.1 Code: L; COG: COG2963 YP_001172382.1 flagellin specific chaperone YP_001172385.1 Code: S; COG: COG3169 YP_001172386.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001172387.1 Code: C; COG: COG2009 YP_001172388.1 Code: C; COG: COG2142 YP_001172389.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001172390.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001172391.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001172392.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001172393.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001172394.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001172395.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001172396.1 Code: E; COG: COG1114 YP_001172397.1 Code: S; COG: COG3821 YP_001172398.1 Code: Q; COG: COG2050 YP_001172399.1 Code: Q; COG: COG2050 YP_001172401.1 molecular chaperone YP_001172402.1 Code: O; COG: COG1765 YP_001172405.1 Code: NT; COG: COG0840 YP_001172406.1 Code: NT; COG: COG0840 YP_001172407.1 involved in the import of serine and threonine coupled with the import of sodium YP_001172408.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001172409.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001172410.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001172412.1 Code: T; COG: COG2062 YP_001172413.1 Code: Q; COG: COG2050 YP_001172414.1 Code: R; COG: COG0596 YP_001172415.1 Code: R; COG: COG0596 YP_001172417.1 Code: R; COG: COG0628 YP_001172418.1 Code: R; COG: COG1752 YP_001172419.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001172420.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001172423.1 Code: R; COG: COG0714 YP_001172424.1 Code: R; COG: COG1721 YP_001172425.1 Code: E; COG: COG1305 YP_001172426.1 Code: I; COG: COG1946 YP_001172429.1 Code: S; COG: COG1238 YP_001172430.1 Code: K; COG: COG2207 YP_001172431.1 Code: IQR; COG: COG1028 YP_001172432.1 Code: I; COG: COG0183 YP_001172433.1 Code: I; COG: COG1960 YP_001172434.1 Code: IQ; COG: COG0318 YP_001172435.1 Code: C; COG: COG1804 YP_001172437.1 Code: L; COG: COG3464 YP_001172438.1 Code: I; COG: COG1960 YP_001172439.1 Code: I; COG: COG1024 YP_001172440.1 Code: I; COG: COG2084 YP_001172441.1 Code: I; COG: COG1024 YP_001172442.1 Code: C; COG: COG1012 YP_001172443.1 Code: K; COG: COG0583 YP_001172445.1 Code: G; COG: COG0058 YP_001172446.1 Code: S; COG: COG3021 YP_001172447.1 Code: M; COG: COG0744 YP_001172448.1 Code: K; COG: COG2207 YP_001172450.1 Code: T; COG: COG3103 YP_001172452.1 Code: P; COG: COG0168 YP_001172453.1 Code: P; COG: COG0569 YP_001172454.1 Code: S; COG: COG3791 YP_001172455.1 Code: C; COG: COG0243 YP_001172456.1 Code: C; COG: COG1526 YP_001172457.1 Code: K; COG: COG0583 YP_001172461.1 Code: I; COG: COG4247 YP_001172462.1 Code: U; COG: COG0811 YP_001172463.1 Code: U; COG: COG0848 YP_001172465.1 Code: R; COG: COG3211 YP_001172467.1 Code: L; COG: COG0210 YP_001172468.1 Code: RTKL; COG: COG0515 YP_001172469.1 Code: P; COG: COG2116 YP_001172470.1 Code: PR; COG: COG2146 YP_001172471.1 Code: C; COG: COG1251 YP_001172472.1 Code: K; COG: COG0846 YP_001172473.1 Code: H; COG: COG0635 YP_001172475.1 Code: M; COG: COG2230 YP_001172476.1 Code: S; COG: COG3496 YP_001172477.1 Code: R; COG: COG2907 YP_001172478.1 Code: IQR; COG: COG1028 YP_001172480.1 Code: L; COG: COG0415 YP_001172481.1 Code: K; COG: COG0789 YP_001172483.1 Code: R; COG: COG1090 YP_001172484.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001172488.1 Code: G; COG: COG2211 YP_001172490.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_001172491.1 Code: H; COG: COG0302 YP_001172492.1 Code: S; COG: COG3011 YP_001172493.1 Code: K; COG: COG0789 YP_001172494.1 Code: O; COG: COG1025 YP_001172496.1 Code: S; COG: COG3287 YP_001172498.1 Code: O; COG: COG0435 YP_001172499.1 Code: E; COG: COG0547 YP_001172500.1 Code: P; COG: COG2920 YP_001172501.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001172503.1 Code: GEPR; COG: COG0477 YP_001172504.1 Code: R; COG: COG0670 YP_001172506.1 Code: K; COG: COG1309 YP_001172507.1 Code: P; COG: COG0715 YP_001172508.1 Code: E; COG: COG0174 YP_001172509.1 Code: E; COG: COG2021 YP_001172510.1 Code: P; COG: COG0600 YP_001172512.1 Code: Q; COG: COG1335 YP_001172513.1 Code: R; COG: COG1402 YP_001172514.1 Code: GER; COG: COG0697 YP_001172515.1 Code: IQR; COG: COG1028 YP_001172516.1 Code: IQR; COG: COG1028 YP_001172518.1 Code: P; COG: COG0715 YP_001172519.1 Code: C; COG: COG0667 YP_001172520.1 catalyzes the hydrolysis of allophanate YP_001172521.1 Code: S; COG: COG3665 YP_001172522.1 Code: S; COG: COG3665 YP_001172523.1 Code: P; COG: COG1116 YP_001172524.1 Code: P; COG: COG0600 YP_001172525.1 Code: NT; COG: COG0840 YP_001172526.1 Code: L; COG: COG0084 YP_001172527.1 Code: M; COG: COG4623 YP_001172528.1 acts as a molecular chaperone to fold and export lipase A YP_001172529.1 Code: R; COG: COG1075 YP_001172530.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001172531.1 Code: Q; COG: COG3127 YP_001172532.1 Code: Q; COG: COG4181 YP_001172533.1 Code: E; COG: COG2755 YP_001172534.1 Code: S; COG: COG1376 YP_001172537.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001172538.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_001172539.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001172540.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001172541.1 catalyzes the formation of serine from phosphoserine; also has phosphoserine:homoserine phosphotransferase activity YP_001172542.1 Code: EH; COG: COG0147 YP_001172545.1 Code: O; COG: COG4067 YP_001172546.1 Code: K; COG: COG1802 YP_001172547.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_001172548.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_001172549.1 Catalyzes the conversion of citrate to isocitrate YP_001172550.1 Code: S; COG: COG2828 YP_001172551.1 Code: S; COG: COG1806 YP_001172552.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001172553.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001172554.1 Code: P; COG: COG0598 YP_001172556.1 Code: M; COG: COG0668 YP_001172557.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in Pseudomonas fluorescens and P. aeruginosa regulates outer membrane protein OprF expression YP_001172558.1 Code: M; COG: COG2885 YP_001172559.2 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001172560.1 Code: R; COG: COG3313 YP_001172561.1 Code: T; COG: COG0589 YP_001172562.1 Code: FJ; COG: COG4445 YP_001172563.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001172564.1 Code: O; COG: COG0652 YP_001172565.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001172566.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001172567.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001172568.1 Code: K; COG: COG2186 YP_001172569.1 Code: R; COG: COG0730 YP_001172570.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001172571.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001172572.1 binds and unfolds substrates as part of the ClpXP protease YP_001172573.1 Code: O; COG: COG0466 YP_001172574.1 Code: L; COG: COG0776 YP_001172575.1 Code: O; COG: COG0760 YP_001172577.1 Code: S; COG: COG3748 YP_001172578.1 Code: R; COG: COG0535 YP_001172581.1 Code: C; COG: COG1012 YP_001172582.1 Code: C; COG: COG1902 YP_001172583.1 possibly involved in transport of pyrroloquinoline quinone transport YP_001172584.1 Required in the synthesis of PPQ, but its exact function is unknown YP_001172585.1 with PqqC converts a biosynthetic intermediate to pyrroloquinoline quinone YP_001172586.1 Code: R; COG: COG0535 YP_001172587.1 Code: E; COG: COG1506 YP_001172588.1 Code: C; COG: COG1454 YP_001172592.1 Code: M; COG: COG0845 YP_001172593.1 Code: P; COG: COG3696 YP_001172595.1 Code: TK; COG: COG2197 YP_001172596.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001172597.1 Code: I; COG: COG0558 YP_001172600.1 Code: OC; COG: COG0526 YP_001172602.1 Code: P; COG: COG0798 YP_001172603.1 Code: P; COG: COG2072 YP_001172604.1 Code: K; COG: COG0640 YP_001172605.1 Code: R; COG: COG0431 YP_001172606.1 Code: T; COG: COG2453 YP_001172607.1 Code: S; COG: COG1742 YP_001172608.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate YP_001172609.1 Code: GEPR; COG: COG0477 YP_001172614.1 Code: KL; COG: COG1199 YP_001172616.1 Code: H; COG: COG0635 YP_001172617.1 Code: NT; COG: COG0840 YP_001172618.1 Code: M; COG: COG1210 YP_001172619.1 Code: E; COG: COG0346 YP_001172620.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001172621.1 Code: S; COG: COG2847 YP_001172623.1 Code: FE; COG: COG0462 YP_001172626.1 Code: K; COG: COG2207 YP_001172627.1 Code: S; COG: COG1289 YP_001172629.1 Code: V; COG: COG1566 YP_001172630.1 Code: MU; COG: COG1538 YP_001172631.1 Code: K; COG: COG0583 YP_001172635.1 Code: IQR; COG: COG1028 YP_001172636.1 catalyzes the formation of acetate from pyruvate YP_001172637.1 catalyzes the ATP dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_001172641.1 Code: S; COG: COG3685 YP_001172643.1 Code: R; COG: COG1546 YP_001172644.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001172645.1 Code: G; COG: COG0296 YP_001172646.1 Code: G; COG: COG1640 YP_001172647.1 Code: G; COG: COG3280 YP_001172649.1 Code: G; COG: COG1523 YP_001172650.1 Code: M; COG: COG0739 YP_001172651.1 Code: C; COG: COG3038 YP_001172652.1 Code: S; COG: COG3384 YP_001172653.1 Code: K; COG: COG0583 YP_001172654.1 Code: ER; COG: COG1063 YP_001172655.1 Code: S; COG: COG1801 YP_001172656.1 Code: R; COG: COG3568 YP_001172657.1 Code: I; COG: COG1502 YP_001172658.1 Code: S; COG: COG0392 YP_001172659.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001172660.1 Code: G; COG: COG0366 YP_001172661.1 Code: G; COG: COG0366 YP_001172663.1 Code: O; COG: COG3058 YP_001172664.1 Code: C; COG: COG2864 YP_001172665.1 Code: C; COG: COG0437 YP_001172666.1 Code: C; COG: COG0243 YP_001172667.1 Code: C; COG: COG0243 YP_001172668.1 Code: L; COG: COG3285 YP_001172669.1 Code: S; COG: COG1273 YP_001172670.1 Code: IQR; COG: COG1028 YP_001172671.1 Code: CR; COG: COG0604 YP_001172672.1 Code: K; COG: COG0583 YP_001172673.1 Code: M; COG: COG0845 YP_001172674.1 Code: MU; COG: COG1538 YP_001172676.1 streptomycin 3'-adenyltransferase YP_001172677.1 Code: S; COG: COG2315 YP_001172678.1 Code: G; COG: COG1638 YP_001172679.1 Code: MU; COG: COG1538 YP_001172680.1 Code: V; COG: COG0841 YP_001172681.1 Code: V; COG: COG0841 YP_001172682.1 Code: M; COG: COG0845 YP_001172684.1 Code: E; COG: COG4091 YP_001172686.1 Code: O; COG: COG2077 YP_001172687.1 Code: E; COG: COG1115 YP_001172688.1 Code: S; COG: COG2911 YP_001172689.1 Code: M; COG: COG0729 YP_001172690.1 Code: KR; COG: COG0454 YP_001172691.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001172692.1 Code: P; COG: COG0226 YP_001172693.1 Code: G; COG: COG0524 YP_001172694.1 Code: K; COG: COG2207 YP_001172695.1 Code: G; COG: COG1653 YP_001172696.1 Code: G; COG: COG1175 YP_001172697.1 Code: G; COG: COG0395 YP_001172698.1 Code: G; COG: COG3839 YP_001172699.1 Code: G; COG: COG0246 YP_001172700.1 Code: G; COG: COG1070 YP_001172701.1 Code: I; COG: COG1960 YP_001172702.1 Code: K; COG: COG0583 YP_001172703.1 Code: K; COG: COG1609 YP_001172704.1 Code: G; COG: COG1638 YP_001172705.1 Code: G; COG: COG1593 YP_001172708.1 Code: O; COG: COG0760 YP_001172710.1 Code: E; COG: COG0665 YP_001172711.1 Code: R; COG: COG2358 YP_001172713.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001172717.1 Code: S; COG: COG2323 YP_001172718.1 Code: L; COG: COG3569 YP_001172724.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001172727.1 Code: H; COG: COG3201 YP_001172728.1 Code: H; COG: COG3172 YP_001172731.1 Code: GEPR; COG: COG0477 YP_001172732.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001172735.1 Code: O; COG: COG0071 YP_001172737.1 Code: P; COG: COG0155 YP_001172738.1 Code: S; COG: COG3749 YP_001172740.1 Code: CR; COG: COG0604 YP_001172741.2 SohB; periplasmic protein; member of the peptidase S49 family YP_001172742.1 Code: G; COG: COG0406 YP_001172743.1 Code: I; COG: COG3255 YP_001172744.1 Code: R; COG: COG3173 YP_001172745.1 Code: IQR; COG: COG1028 YP_001172747.1 Code: R; COG: COG0730 YP_001172748.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001172750.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001172751.1 Code: E; COG: COG1982 YP_001172752.1 3'-5' exonuclease of DNA polymerase III YP_001172753.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001172754.1 Code: QR; COG: COG0500 YP_001172755.1 Code: R; COG: COG0491 YP_001172758.1 Code: E; COG: COG4166 YP_001172759.1 Code: E; COG: COG4166 YP_001172760.1 Code: R; COG: COG4174 YP_001172761.1 Code: R; COG: COG4239 YP_001172763.1 Code: I; COG: COG0623 YP_001172764.1 Code: IQR; COG: COG1028 YP_001172765.1 Code: K; COG: COG2207 YP_001172766.1 Code: G; COG: COG4993 YP_001172768.1 Code: R; COG: COG0491 YP_001172771.1 Code: C; COG: COG2010 YP_001172772.1 Code: G; COG: COG4993 YP_001172773.1 Code: S; COG: COG1357 YP_001172778.1 Code: TK; COG: COG2197 YP_001172785.1 Code: V; COG: COG1131 YP_001172786.1 Code: V; COG: COG0842 YP_001172787.1 Code: P; COG: COG0607 YP_001172788.1 Code: TK; COG: COG2197 YP_001172790.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001172791.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001172792.1 Code: L; COG: COG2256 YP_001172793.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001172794.1 Code: D; COG: COG1674 YP_001172795.1 Code: O; COG: COG0492 YP_001172796.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001172797.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_001172798.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001172799.1 Code: O; COG: COG0542 YP_001172800.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_001172801.1 Code: K; COG: COG1278 YP_001172802.1 Code: C; COG: COG0538 YP_001172803.1 Code: C; COG: COG2838 YP_001172804.1 Code: LR; COG: COG0494 YP_001172805.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001172806.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001172807.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001172808.1 Code: S; COG: COG2850 YP_001172809.1 Code: KR; COG: COG0454 YP_001172812.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_001172813.1 Code: R; COG: COG3211 YP_001172814.1 Code: R; COG: COG0628 YP_001172815.1 Code: L; COG: COG2963 YP_001172816.1 Code: L; COG: COG2801 YP_001172817.1 Code: R; COG: COG2056 YP_001172818.1 Code: H; COG: COG0720 YP_001172819.1 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline YP_001172820.1 Involved in ubiquinone biosynthesis YP_001172821.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001172822.1 Code: IQR; COG: COG1028 YP_001172823.1 Code: J; COG: COG1187 YP_001172824.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001172825.1 Code: G; COG: COG0363 YP_001172826.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001172827.1 involved in methylation of ribosomal protein L3 YP_001172828.1 Code: Q; COG: COG1335 YP_001172829.1 Code: S; COG: COG2840 YP_001172830.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001172831.1 Code: O; COG: COG0625 YP_001172832.1 Code: KE; COG: COG1167 YP_001172833.1 Code: K; COG: COG1846 YP_001172834.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001172835.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001172836.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate and catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001172837.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001172838.1 Code: E; COG: COG0077 YP_001172839.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001172840.1 negatively supercoils closed circular double-stranded DNA YP_001172841.1 isomerizes methylthioribose-1-phosphate into methylthioribulose-1-phosphate; involved in methionine salvage pathway YP_001172843.1 Code: L; COG: COG0389 YP_001172844.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. YP_001172846.1 catalyzes the formation of pyruvate from D-cysteine YP_001172847.1 Code: ET; COG: COG0834 YP_001172848.1 Code: E; COG: COG0765 YP_001172849.1 Code: E; COG: COG1126 YP_001172851.1 Code: C; COG: COG2141 YP_001172853.1 Code: P; COG: COG0475 YP_001172854.1 Code: S; COG: COG3431 YP_001172855.1 Code: O; COG: COG0542 YP_001172858.1 Code: K; COG: COG0789 YP_001172859.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001172860.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001172861.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001172862.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001172863.1 Code: J; COG: COG0291 YP_001172864.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001172865.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001172866.1 Code: E; COG: COG0665 YP_001172871.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001172873.1 Code: OC; COG: COG0526 YP_001172875.1 Code: S; COG: COG4575 YP_001172876.1 Code: S; COG: COG5393 YP_001172878.1 dGTPase family type 3 subfamily, presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001172880.1 Code: S; COG: COG3171 YP_001172881.1 Code: M; COG: COG2027 YP_001172882.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001172883.1 Code: J; COG: COG3130 YP_001172884.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001172887.1 Code: E; COG: COG2902 YP_001172888.1 Code: R; COG: COG0714 YP_001172889.1 Code: R; COG: COG1721 YP_001172891.1 Code: R; COG: COG2304 YP_001172892.1 Code: R; COG: COG2304 YP_001172894.1 Code: P; COG: COG0715 YP_001172895.1 Code: T; COG: COG3707 YP_001172898.1 Code: G; COG: COG1105 YP_001172900.1 Code: P; COG: COG2223 YP_001172903.1 Code: C; COG: COG1251 YP_001172904.1 Code: PR; COG: COG2146 YP_001172905.1 Code: C; COG: COG0243 YP_001172906.1 catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1 YP_001172907.1 Code: R; COG: COG1033 YP_001172908.1 Code: R; COG: COG4447 YP_001172909.1 Code: E; COG: COG0308 YP_001172911.1 Code: S; COG: COG3139 YP_001172912.1 Code: R; COG: COG0705 YP_001172913.1 Code: T; COG: COG0639 YP_001172914.1 catalyzes the phosphorylation of NAD to NADP YP_001172915.1 Code: S; COG: COG3782 YP_001172916.1 Code: P; COG: COG2059 YP_001172918.1 Code: K; COG: COG0583 YP_001172920.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001172921.1 Code: L; COG: COG0122 YP_001172925.1 Code: S; COG: COG1791 YP_001172926.1 Code: GEPR; COG: COG0477 YP_001172927.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001172928.1 Code: R; COG: COG1073 YP_001172930.1 Code: G; COG: COG4580 YP_001172931.1 Code: G; COG: COG3839 YP_001172932.1 Code: G; COG: COG0395 YP_001172933.1 Code: G; COG: COG1175 YP_001172934.1 Code: G; COG: COG1653 YP_001172935.1 Code: T; COG: COG0642 YP_001172936.1 Code: TK; COG: COG0745 YP_001172937.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001172938.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001172939.1 Code: K; COG: COG1386 YP_001172940.1 Code: S; COG: COG1354 YP_001172941.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001172942.1 Code: J; COG: COG0009 YP_001172943.1 Code: R; COG: COG0613 YP_001172944.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001172946.1 Code: TK; COG: COG0745 YP_001172947.1 Code: UNTP; COG: COG3678 YP_001172948.1 Code: T; COG: COG0642 YP_001172949.1 Code: C; COG: COG0778 YP_001172950.1 Code: R; COG: COG0727 YP_001172951.1 Code: P; COG: COG0168 YP_001172952.1 Code: S; COG: COG2354 YP_001172953.1 Code: K; COG: COG2207 YP_001172954.1 Code: S; COG: COG4323 YP_001172955.1 Code: T; COG: COG2114 YP_001172956.1 Code: K; COG: COG2207 YP_001172957.1 Code: GER; COG: COG0697 YP_001172958.1 Code: O; COG: COG3526 YP_001172960.1 Code: K; COG: COG1846 YP_001172961.1 Code: L; COG: COG0514 YP_001172962.1 related to the C-terminal domain of SecA; Code: R; COG: COG3318 YP_001172963.1 Code: S; COG: COG2832 YP_001172964.1 Code: S; COG: COG3148 YP_001172965.1 Code: O; COG: COG0625 YP_001172967.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_001172968.1 Code: GER; COG: COG0697 YP_001172969.1 Code: E; COG: COG0031 YP_001172971.1 Code: R; COG: COG0714 YP_001172972.1 Code: S; COG: COG3791 YP_001172973.1 Code: S; COG: COG3825 YP_001172975.1 Code: R; COG: COG0121 YP_001172977.1 Code: T; COG: COG0589 YP_001172979.1 Code: R; COG: COG0488 YP_001172980.1 Code: M; COG: COG0741 YP_001172981.1 Code: R; COG: COG3217 YP_001172983.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_001172985.1 Code: M; COG: COG2148 YP_001172986.1 Code: T; COG: COG0394 YP_001172987.1 Code: M; COG: COG3206 YP_001172988.1 Code: G; COG: COG2730 YP_001172993.1 Code: R; COG: COG1216 YP_001172994.1 Code: M; COG: COG1922 YP_001172995.1 Code: M; COG: COG1596 YP_001172996.1 Code: I; COG: COG0183 YP_001172997.1 Code: S; COG: COG2326 YP_001172998.1 Code: Q; COG: COG2977 YP_001173000.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001173001.1 Code: LKJ; COG: COG0513 YP_001173003.1 Code: E; COG: COG0421 YP_001173004.1 Code: E; COG: COG3200 YP_001173005.1 Code: P; COG: COG0471 YP_001173006.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001173007.1 Code: S; COG: COG4394 YP_001173009.1 Code: R; COG: COG3380 YP_001173010.1 Code: N; COG: COG1291 YP_001173011.1 Code: N; COG: COG1360 YP_001173012.1 Code: P; COG: COG0428 YP_001173014.1 Code: M; COG: COG4591 YP_001173015.1 Code: V; COG: COG1136 YP_001173016.1 Code: R; COG: COG0491 YP_001173017.1 Code: R; COG: COG0446 YP_001173018.1 Code: P; COG: COG0659 YP_001173019.1 Code: P; COG: COG0607 YP_001173020.1 Code: R; COG: COG2391 YP_001173021.1 Code: R; COG: COG2391 YP_001173022.1 Code: K; COG: COG0640 YP_001173025.1 Code: O; COG: COG0625 YP_001173026.1 Code: R; COG: COG2607 YP_001173027.1 Code: O; COG: COG0386 YP_001173028.1 Code: O; COG: COG0229 YP_001173029.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001173031.1 putative metalloprotease YP_001173033.1 Code: QR; COG: COG0500 YP_001173034.1 Code: T; COG: COG2204 YP_001173035.1 Code: T; COG: COG0642 YP_001173036.1 Code: T; COG: COG2204 YP_001173039.1 Code: O; COG: COG4235 YP_001173040.1 Code: O; COG: COG3088 YP_001173041.1 Code: OC; COG: COG0526 YP_001173042.1 Code: O; COG: COG1138 YP_001173043.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001173044.1 Code: U; COG: COG3114 YP_001173045.1 Code: O; COG: COG0755 YP_001173046.1 Code: O; COG: COG2386 YP_001173047.1 ATP-binding protein; required for proper cytochrome c maturation YP_001173049.1 Code: S; COG: COG2257 YP_001173052.1 Code: NT; COG: COG0835 YP_001173054.1 Code: D; COG: COG1192 YP_001173055.1 Homologous to MotB. These organism have both MotB and MotD. With MotC (a MotA homolog) forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. Either MotAB or MotCD is sufficient for swimming, but both are necessary for swarming motility YP_001173056.1 Code: N; COG: COG1291 YP_001173057.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001173058.1 Code: NT; COG: COG0643 YP_001173059.1 Code: NT; COG: COG3143 YP_001173060.1 Code: T; COG: COG0784 YP_001173061.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001173062.1 Code: D; COG: COG0455 YP_001173063.1 positive regulator of class III flagellar genes YP_001173064.1 membrane protein involved in the flagellar export apparatus YP_001173065.1 Code: P; COG: COG2032 YP_001173066.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001173067.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001173068.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001173069.1 Code: NU; COG: COG1338 YP_001173070.1 Code: N; COG: COG3190 YP_001173071.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001173072.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001173073.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001173074.1 Code: N; COG: COG3144 YP_001173075.1 Code: T; COG: COG2198 YP_001173076.1 Code: TK; COG: COG2208 YP_001173077.1 Code: T; COG: COG1366 YP_001173078.1 rod/hook and filament chaperone YP_001173079.1 involved in type III protein export during flagellum assembly YP_001173080.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001173081.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001173082.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001173083.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001173084.1 Code: Q; COG: COG3135 YP_001173085.1 Code: IQR; COG: COG1028 YP_001173086.1 Code: R; COG: COG2130 YP_001173087.1 Code: F; COG: COG0284 YP_001173091.1 Code: KE; COG: COG1167 YP_001173092.1 Code: M; COG: COG2885 YP_001173094.1 Code: ET; COG: COG0834 YP_001173096.1 Code: C; COG: COG2025 YP_001173097.1 Code: C; COG: COG2086 YP_001173099.1 Code: C; COG: COG0644 YP_001173100.1 Code: S; COG: COG3816 YP_001173102.1 Code: C; COG: COG1032 YP_001173103.1 Code: K; COG: COG1309 YP_001173104.1 Code: E; COG: COG0520 YP_001173105.1 Code: E; COG: COG1113 YP_001173106.1 Code: L; COG: COG0084 YP_001173107.1 Code: NU; COG: COG3215 YP_001173108.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001173109.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001173110.1 Code: R; COG: COG1559 YP_001173111.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001173112.2 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001173113.1 carries the fatty acid chain in fatty acid biosynthesis YP_001173114.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001173115.1 Code: I; COG: COG0331 YP_001173116.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001173117.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001173118.1 Code: R; COG: COG1399 YP_001173119.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001173120.1 Code: OU; COG: COG0616 YP_001173121.1 Code: R; COG: COG0546 YP_001173122.1 Code: J; COG: COG0564 YP_001173124.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001173125.1 Code: T; COG: COG0394 YP_001173126.1 Code: M; COG: COG1212 YP_001173127.1 Code: S; COG: COG2835 YP_001173128.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001173129.1 Code: U; COG: COG0848 YP_001173130.1 Code: U; COG: COG0811 YP_001173131.1 Code: R; COG: COG0658 YP_001173132.1 Code: S; COG: COG3216 YP_001173133.1 Code: M; COG: COG4591 YP_001173134.1 Code: V; COG: COG1136 YP_001173135.1 Code: M; COG: COG4591 YP_001173138.1 Code: C; COG: COG0584 YP_001173139.1 catalyzes the conversion of NADPH to NADH YP_001173140.1 Code: S; COG: COG2991 YP_001173141.1 Code: H; COG: COG1477 YP_001173142.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001173143.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_001173144.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_001173145.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001173146.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001173147.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001173148.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_001173149.1 Code: LK; COG: COG1197 YP_001173151.1 Code: KL; COG: COG0553 YP_001173153.1 Code: J; COG: COG1236 YP_001173154.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single strand break in duplex DNA YP_001173155.1 Code: R; COG: COG1201 YP_001173156.1 Code: R; COG: COG1407 YP_001173158.1 Code: R; COG: COG2312 YP_001173159.1 Code: S; COG: COG3122 YP_001173160.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001173161.1 Code: TK; COG: COG0317 YP_001173162.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001173163.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001173164.1 specific inhibitor of chromosomal initiation of replication in vitro; inds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001173165.1 Code: S; COG: COG2860 YP_001173167.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001173169.1 Code: R; COG: COG0730 YP_001173170.1 Code: S; COG: COG5457 YP_001173171.1 Code: K; COG: COG0583 YP_001173174.1 Code: LKJ; COG: COG0513 YP_001173176.1 Code: K; COG: COG0583 YP_001173177.1 Code: O; COG: COG0652 YP_001173179.1 Code: S; COG: COG3146 YP_001173180.1 Code: P; COG: COG3746 YP_001173181.1 Code: H; COG: COG1179 YP_001173182.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001173183.1 Code: QR; COG: COG0500 YP_001173186.1 Code: N; COG: COG3225 YP_001173187.1 Code: R; COG: COG1277 YP_001173188.1 Code: V; COG: COG1131 YP_001173190.1 Code: J; COG: COG1670 YP_001173191.1 Code: V; COG: COG2602 YP_001173192.1 Code: QR; COG: COG0500 YP_001173194.1 Code: R; COG: COG5485 YP_001173195.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001173196.1 Code: KR; COG: COG0454 YP_001173198.1 Involved in disulfide bond formation YP_001173199.1 Code: OC; COG: COG0526 YP_001173200.1 Code: OC; COG: COG4232 YP_001173201.1 Code: TK; COG: COG0745 YP_001173202.1 Code: T; COG: COG0642 YP_001173203.1 Code: T; COG: COG0642 YP_001173204.1 Code: TK; COG: COG0745 YP_001173205.1 Code: P; COG: COG2608 YP_001173206.1 Code: R; COG: COG3019 YP_001173207.1 Code: Q; COG: COG2132 YP_001173209.1 Code: P; COG: COG3667 YP_001173213.1 stationary phase protein that binds TrpR repressor YP_001173214.1 Code: R; COG: COG1741 YP_001173216.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001173217.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001173218.1 Code: G; COG: COG1472 YP_001173219.1 Code: R; COG: COG0384 YP_001173220.1 Code: M; COG: COG1346 YP_001173221.1 Code: R; COG: COG1380 YP_001173222.1 Code: C; COG: COG0348 YP_001173223.1 Code: KE; COG: COG1167 YP_001173225.1 Code: R; COG: COG0491 YP_001173226.1 Code: O; COG: COG0625 YP_001173227.1 Code: K; COG: COG1309 YP_001173228.1 Code: V; COG: COG0841 YP_001173229.1 Code: M; COG: COG0845 YP_001173230.1 Code: K; COG: COG1309 YP_001173231.1 Code: QR; COG: COG0500 YP_001173232.1 Code: S; COG: COG3921 YP_001173233.1 Code: S; COG: COG1801 YP_001173235.1 Code: O; COG: COG1214 YP_001173236.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001173237.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001173240.1 Code: M; COG: COG2885 YP_001173242.1 Code: S; COG: COG2013 YP_001173245.1 Code: S; COG: COG3930 YP_001173246.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001173247.1 Code: J; COG: COG1186 YP_001173248.1 Code: S; COG: COG2979 YP_001173249.1 Code: C; COG: COG1902 YP_001173250.1 Code: C; COG: COG0243 YP_001173251.1 Code: L; COG: COG0608 YP_001173252.1 Code: K; COG: COG5631 YP_001173253.1 Code: R; COG: COG1540 YP_001173254.1 Code: E; COG: COG2049 YP_001173255.1 Code: E; COG: COG1984 YP_001173256.1 Code: S; COG: COG4336 YP_001173257.1 Code: P; COG: COG1914 YP_001173258.1 Code: S; COG: COG4681 YP_001173261.1 Code: P; COG: COG2193 YP_001173262.1 Code: O; COG: COG0545 YP_001173263.1 Required for efficient pilin antigenic variation YP_001173264.1 Code: GEPR; COG: COG0477 YP_001173265.1 Code: S; COG: COG4392 YP_001173266.1 Code: E; COG: COG1296 YP_001173267.1 Code: J; COG: COG1670 YP_001173270.1 Code: S; COG: COG3174 YP_001173271.1 Code: S; COG: COG1322 YP_001173276.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_001173277.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001173278.1 Code: M; COG: COG3317 YP_001173279.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001173280.1 Code: E; COG: COG2716 YP_001173281.1 Code: O; COG: COG1225 YP_001173282.1 Code: R; COG: COG0628 YP_001173283.1 Code: O; COG: COG0425 YP_001173284.1 Code: R; COG: COG4783 YP_001173285.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001173286.1 Code: C; COG: COG0427 YP_001173287.1 Code: R; COG: COG0603 YP_001173288.1 Code: O; COG: COG0602 YP_001173289.1 Code: S; COG: COG1729 YP_001173290.1 Code: M; COG: COG2885 YP_001173291.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001173293.1 Code: U; COG: COG0848 YP_001173294.1 Code: U; COG: COG0811 YP_001173295.1 Code: R; COG: COG0824 YP_001173296.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001173297.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001173298.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001173299.1 Code: S; COG: COG0217 YP_001173300.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001173302.1 Code: P; COG: COG0783 YP_001173304.1 Code: S; COG: COG2900 YP_001173305.1 Code: FGR; COG: COG0537 YP_001173307.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001173309.1 Code: M; COG: COG0741 YP_001173310.1 Code: OC; COG: COG0526 YP_001173312.1 Code: S; COG: COG1295 YP_001173314.1 Code: R; COG: COG0655 YP_001173315.1 Code: S; COG: COG3308 YP_001173316.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_001173317.1 Code: R; COG: COG0628 YP_001173318.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001173319.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001173321.1 Code: S; COG: COG3650 YP_001173322.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate YP_001173325.1 Code: OC; COG: COG0526 YP_001173326.1 Code: P; COG: COG1393 YP_001173327.1 Code: E; COG: COG2171 YP_001173328.1 Code: E; COG: COG0520 YP_001173329.1 Code: R; COG: COG2166 YP_001173330.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001173331.1 Code: C; COG: COG3258 YP_001173332.1 Code: C; COG: COG2863 YP_001173334.1 Code: S; COG: COG3530 YP_001173335.1 Code: R; COG: COG0666 YP_001173336.1 Code: S; COG: COG2606 YP_001173337.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001173338.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001173340.1 Code: K; COG: COG0583 YP_001173341.1 Code: IQR; COG: COG1028 YP_001173342.1 Code: S; COG: COG2764 YP_001173343.1 Code: E; COG: COG1280 YP_001173345.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001173347.1 Code: M; COG: COG1462 YP_001173350.1 Code: M; COG: COG3248 YP_001173351.1 Code: K; COG: COG1309 YP_001173352.1 Code: K; COG: COG0583 YP_001173353.1 Code: O; COG: COG4067 YP_001173354.1 Code: R; COG: COG1092 YP_001173355.1 Code: J; COG: COG1236 YP_001173356.1 Code: E; COG: COG0346 YP_001173357.1 Code: E; COG: COG0405 YP_001173361.1 Code: P; COG: COG0659 YP_001173363.1 Code: IQ; COG: COG0236 YP_001173364.1 Code: Q; COG: COG3882 YP_001173365.1 Code: M; COG: COG1696 YP_001173368.1 Code: M; COG: COG1091 YP_001173369.1 Code: E; COG: COG1280 YP_001173371.1 Code: IQR; COG: COG1028 YP_001173373.1 Code: T; COG: COG0467 YP_001173376.1 Code: V; COG: COG1132 YP_001173378.1 Code: M; COG: COG0562 YP_001173379.1 Code: M; COG: COG0438 YP_001173380.1 Code: M; COG: COG1087 YP_001173382.1 Code: K; COG: COG0583 YP_001173383.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001173384.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001173385.1 Code: R; COG: COG3491 YP_001173387.1 Code: P; COG: COG0715 YP_001173388.1 Code: P; COG: COG1116 YP_001173389.1 Code: P; COG: COG0600 YP_001173390.1 Code: FJ; COG: COG0590 YP_001173391.1 Code: R; COG: COG4221 YP_001173392.1 Code: S; COG: COG0599 YP_001173393.1 Code: K; COG: COG2207 YP_001173396.1 Code: R; COG: COG4603 YP_001173397.1 Code: R; COG: COG1079 YP_001173400.1 Code: C; COG: COG1301 YP_001173401.1 decatenates replicating daughter chromosomes YP_001173403.1 Code: R; COG: COG4757 YP_001173404.1 Code: P; COG: COG0471 YP_001173406.1 Code: G; COG: COG2814 YP_001173407.1 Code: R; COG: COG1073 YP_001173408.1 Code: S; COG: COG4275 YP_001173409.1 Code: P; COG: COG2059 YP_001173410.1 Code: R; COG: COG0596 YP_001173413.1 Code: K; COG: COG2207 YP_001173414.1 Code: E; COG: COG1280 YP_001173416.1 Code: NT; COG: COG0840 YP_001173418.1 Code: S; COG: COG2733 YP_001173419.1 Code: P; COG: COG1116 YP_001173420.1 Code: P; COG: COG0600 YP_001173422.1 Code: FGR; COG: COG0537 YP_001173423.1 catalyzes the release of C-terminal glutamate residues from N-acylating moieties YP_001173424.1 Code: S; COG: COG2258 YP_001173425.1 Code: S; COG: COG3904 YP_001173426.1 Code: R; COG: COG1266 YP_001173427.1 Code: S; COG: COG3795 YP_001173428.1 Code: S; COG: COG2764 YP_001173429.1 Code: S; COG: COG3503 YP_001173430.1 Code: C; COG: COG2851 YP_001173431.1 Code: NU; COG: COG3170 YP_001173432.1 Code: R; COG: COG1234 YP_001173433.1 Code: Q; COG: COG0412 YP_001173434.1 Code: R; COG: COG0596 YP_001173435.1 Code: R; COG: COG3257 YP_001173436.1 Code: J; COG: COG0293 YP_001173437.1 Code: R; COG: COG2509 YP_001173438.1 Code: J; COG: COG0566 YP_001173439.1 Code: T; COG: COG0631 YP_001173442.1 Code: R; COG: COG2962 YP_001173443.1 Code: L; COG: COG1643 YP_001173444.1 Code: R; COG: COG2234 YP_001173446.1 Code: NT; COG: COG0840 YP_001173447.1 Code: NT; COG: COG0840 YP_001173448.1 activates fatty acids by binding to coenzyme A; involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids YP_001173449.2 Disruption of the fadD2 gene did not have any effect on the catabolism of acetic, butyric and longer fatty acids (aliphatic or aromatic); however, might be involved in the specific activation of other fatty acids and may be functional when FadD1 is inactivated. YP_001173450.1 Code: I; COG: COG2030 YP_001173451.1 Code: G; COG: COG1523 YP_001173455.1 Code: L; COG: COG3145 YP_001173457.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001173459.1 Code: O; COG: COG0443 YP_001173460.1 Code: GEPR; COG: COG0477 YP_001173461.1 Code: G; COG: COG3622 YP_001173462.1 Code: I; COG: COG2084 YP_001173463.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001173465.1 Code: P; COG: COG3221 YP_001173466.1 Code: P; COG: COG3638 YP_001173467.1 Code: P; COG: COG3639 YP_001173468.1 Code: P; COG: COG3639 YP_001173469.1 Code: S; COG: COG5626 YP_001173470.1 Code: E; COG: COG0683 YP_001173471.1 Code: E; COG: COG0559 YP_001173472.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001173473.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001173474.1 Code: E; COG: COG0410 YP_001173475.1 Code: Q; COG: COG0412 YP_001173477.1 Code: O; COG: COG3187 YP_001173478.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001173479.1 Code: R; COG: COG0824 YP_001173480.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001173481.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001173482.2 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001173484.1 Code: L; COG: COG3464 YP_001173485.1 Code: O; COG: COG0278 YP_001173486.2 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001173487.1 Code: E; COG: COG3842 YP_001173488.1 Code: FJ; COG: COG0590 YP_001173489.1 Code: Q; COG: COG2132 YP_001173490.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001173491.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001173493.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001173494.1 Code: M; COG: COG0739 YP_001173495.1 Code: Q; COG: COG1335 YP_001173496.1 Code: M; COG: COG0668 YP_001173497.1 Code: P; COG: COG1629 YP_001173499.1 Code: E; COG: COG0119 YP_001173500.1 Code: R; COG: COG1064 YP_001173501.1 Code: GER; COG: COG0697 YP_001173502.1 Code: L; COG: COG2356 YP_001173503.1 Code: S; COG: COG3647 YP_001173506.1 Code: E; COG: COG0531 YP_001173507.1 Code: R; COG: COG0388 YP_001173508.1 catalyzes the transfer of an amino moiety YP_001173509.1 Code: E; COG: COG1045 YP_001173510.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001173511.1 Code: S; COG: COG1520 YP_001173512.1 Code: S; COG: COG2976 YP_001173513.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001173514.1 Code: I; COG: COG0821 YP_001173515.1 Code: S; COG: COG1426 YP_001173516.1 Code: NU; COG: COG3063 YP_001173517.1 Code: R; COG: COG0820 YP_001173518.1 Code: F; COG: COG0105 YP_001173519.1 Code: S; COG: COG2975 YP_001173520.1 Code: C; COG: COG0633 YP_001173521.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001173522.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001173524.1 Code: C; COG: COG0822 YP_001173525.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001173526.1 Code: K; COG: COG1959 YP_001173527.1 Code: E; COG: COG1045 YP_001173528.1 Code: J; COG: COG0565 YP_001173529.1 Code: G; COG: COG0483 YP_001173530.1 Code: S; COG: COG3134 YP_001173531.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001173532.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001173533.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001173534.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001173535.1 Code: J; COG: COG0809 YP_001173536.1 Code: K; COG: COG1278 YP_001173537.1 Code: S; COG: COG1714 YP_001173538.1 Code: R; COG: COG0795 YP_001173539.1 Code: R; COG: COG0795 YP_001173540.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001173541.1 Code: L; COG: COG2927 YP_001173543.2 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001173544.1 Code: P; COG: COG1055 YP_001173545.1 Code: S; COG: COG4519 YP_001173547.1 Code: GEPR; COG: COG0477 YP_001173548.1 Code: R; COG: COG3129 YP_001173550.1 Code: GEPR; COG: COG0477 YP_001173552.1 Code: R; COG: COG3081 YP_001173553.1 Code: S; COG: COG2326 YP_001173555.1 Code: O; COG: COG0625 YP_001173556.1 Code: L; COG: COG2827 YP_001173557.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001173558.1 Code: P; COG: COG0474 YP_001173559.1 Code: IQR; COG: COG1028 YP_001173560.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_001173561.1 Code: R; COG: COG1744 YP_001173562.1 Code: R; COG: COG3491 YP_001173563.1 Code: F; COG: COG4630 YP_001173564.1 Code: F; COG: COG4631 YP_001173565.1 Code: O; COG: COG1975 YP_001173566.1 Catalyzes the deamination of guanine YP_001173567.1 Code: P; COG: COG1108 YP_001173568.1 Code: K; COG: COG1802 YP_001173570.1 Code: R; COG: COG2252 YP_001173571.1 Code: E; COG: COG1280 YP_001173572.1 Code: R; COG: COG2351 YP_001173573.1 Code: G; COG: COG0726 YP_001173574.1 Code: S; COG: COG3195 YP_001173575.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_001173576.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_001173577.1 Code: S; COG: COG3748 YP_001173578.1 Code: P; COG: COG0474 YP_001173579.1 Code: M; COG: COG3248 YP_001173580.1 Code: NT; COG: COG0840 YP_001173581.1 Code: K; COG: COG1309 YP_001173582.1 Code: GEPR; COG: COG0477 YP_001173583.1 Code: V; COG: COG1566 YP_001173585.1 Code: MU; COG: COG1538 YP_001173588.1 Code: L; COG: COG0708 YP_001173589.1 Code: T; COG: COG0642 YP_001173590.1 Code: TK; COG: COG0745 YP_001173591.1 Code: R; COG: COG3193 YP_001173592.1 Code: R; COG: COG2351 YP_001173593.1 Code: K; COG: COG0583 YP_001173594.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_001173595.1 Code: G; COG: COG3622 YP_001173596.1 Code: I; COG: COG2084 YP_001173597.1 Code: G; COG: COG2379 YP_001173598.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001173601.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_001173605.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001173606.1 Code: T; COG: COG2199 YP_001173610.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001173611.1 Code: R; COG: COG1279 YP_001173612.1 Code: P; COG: COG0605 YP_001173614.1 Code: E; COG: COG0421 YP_001173616.1 Code: S; COG: COG1704 YP_001173617.1 Code: P; COG: COG3487 YP_001173618.1 Code: C; COG: COG3488 YP_001173619.1 Code: R; COG: COG3489 YP_001173620.1 Code: S; COG: COG3490 YP_001173621.1 Code: NT; COG: COG0840 YP_001173622.1 Code: M; COG: COG0845 YP_001173623.1 MexW; inner membrane protein; member of RND (resistance, nodulation, and division) family; involved in resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin, ethidium bromide, and acriflavine; functions along with MexV and OprM YP_001173625.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001173626.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001173627.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001173628.1 Code: P; COG: COG0748 YP_001173629.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001173631.1 Code: GEPR; COG: COG0477 YP_001173632.1 Code: M; COG: COG0668 YP_001173633.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001173634.1 Code: T; COG: COG3706 YP_001173635.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_001173636.1 Code: T; COG: COG0642 YP_001173637.1 Code: S; COG: COG2096 YP_001173639.1 Code: R; COG: COG1073 YP_001173641.1 Code: O; COG: COG3634 YP_001173642.1 Code: O; COG: COG0450 YP_001173644.1 Code: O; COG: COG0625 YP_001173645.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001173646.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_001173647.1 Code: S; COG: COG4701 YP_001173649.1 Code: S; COG: COG3141 YP_001173651.1 Code: K; COG: COG2909 YP_001173654.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively YP_001173655.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001173656.1 Code: F; COG: COG2233 YP_001173659.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001173660.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001173661.1 Code: J; COG: COG2890 YP_001173662.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001173663.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001173664.1 Code: R; COG: COG0457 YP_001173665.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001173666.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001173667.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001173668.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001173669.1 Code: J; COG: COG0193 YP_001173670.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001173671.1 Code: L; COG: COG0582 YP_001173673.1 Code: KL; COG: COG0553 YP_001173679.1 Code: L; COG: COG3436 YP_001173680.1 Code: L; COG: COG3436 YP_001173682.1 Code: E; COG: COG4177 YP_001173683.1 Code: E; COG: COG0559 YP_001173684.1 Code: E; COG: COG0683 YP_001173685.1 Code: E; COG: COG0410 YP_001173686.1 Code: E; COG: COG0411 YP_001173688.1 Code: S; COG: COG2128 YP_001173689.1 activates fatty acids by binding to coenzyme A YP_001173691.1 Code: I; COG: COG1960 YP_001173692.1 Code: I; COG: COG4799 YP_001173693.1 catalyzes the hydration of gamma-carboxygeranoyl-CoA to 3-hydroxy-gamma-carboxygeranoyl-CoA YP_001173694.1 Code: I; COG: COG4770 YP_001173695.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_001173696.1 Code: I; COG: COG1788 YP_001173697.1 Code: I; COG: COG2057 YP_001173698.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001173699.1 Code: K; COG: COG0789 YP_001173700.1 Code: Q; COG: COG4663 YP_001173701.1 Code: Q; COG: COG4665 YP_001173702.1 Code: Q; COG: COG4664 YP_001173703.1 Code: KT; COG: COG3829 YP_001173704.1 Code: S; COG: COG2259 YP_001173706.1 Code: L; COG: COG3436 YP_001173707.1 Code: L; COG: COG3436 YP_001173710.1 Code: GER; COG: COG0697 YP_001173711.1 Code: P; COG: COG0288 YP_001173712.1 Code: G; COG: COG0380 YP_001173713.1 Code: G; COG: COG1877 YP_001173715.1 Code: R; COG: COG0456 YP_001173717.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001173718.1 Code: E; COG: COG1748 YP_001173719.1 Code: E; COG: COG0019 YP_001173723.1 Code: R; COG: COG3008 YP_001173726.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001173727.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001173728.1 Code: I; COG: COG1183 YP_001173729.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001173730.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001173731.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_001173733.1 Code: S; COG: COG3098 YP_001173735.1 Code: M; COG: COG0744 YP_001173736.1 Code: S; COG: COG2187 YP_001173737.1 Code: QR; COG: COG0500 YP_001173738.1 Code: K; COG: COG3070 YP_001173739.1 Code: T; COG: COG0664 YP_001173740.1 Code: S; COG: COG3016 YP_001173741.1 with HmuTU is involved in the transport of hemin YP_001173742.1 Code: P; COG: COG0609 YP_001173743.1 Code: PR; COG: COG2146 YP_001173744.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001173745.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001173746.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001173747.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001173748.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001173750.1 Code: J; COG: COG0042 YP_001173751.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001173752.1 involved in de novo purine biosynthesis YP_001173753.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001173755.1 Code: Q; COG: COG2124 YP_001173756.1 Code: S; COG: COG0392 YP_001173758.1 Code: R; COG: COG0679 YP_001173759.1 Code: M; COG: COG1091 YP_001173760.1 Regulatory factor involved in maltose metabolism YP_001173761.1 Code: E; COG: COG0436 YP_001173762.1 Code: T; COG: COG1734 YP_001173763.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_001173765.1 Code: ER; COG: COG0591 YP_001173766.1 Code: T; COG: COG2204 YP_001173767.1 Code: J; COG: COG0617 YP_001173768.1 Code: H; COG: COG0801 YP_001173769.1 Code: H; COG: COG0413 YP_001173770.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001173771.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001173772.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001173773.1 Code: S; COG: COG3662 YP_001173778.1 Code: R; COG: COG2823 YP_001173779.1 Code: J; COG: COG1185 YP_001173780.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001173781.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001173782.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001173783.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001173784.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001173785.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001173786.1 Code: U; COG: COG1314 YP_001173787.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001173788.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001173789.1 Code: H; COG: COG0294 YP_001173790.1 Code: O; COG: COG0465 YP_001173791.1 Code: J; COG: COG1534 YP_001173793.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001173794.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001173795.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001173796.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001173797.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001173798.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001173799.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001173800.1 Code: L; COG: COG0497 YP_001173801.1 Code: P; COG: COG0735 YP_001173802.1 Code: J; COG: COG2913 YP_001173803.1 Code: S; COG: COG2914 YP_001173804.1 Code: I; COG: COG2867 YP_001173805.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001173806.1 Code: K; COG: COG2186 YP_001173807.1 Code: C; COG: COG1620 YP_001173808.1 Code: C; COG: COG0247 YP_001173809.1 Code: C; COG: COG1139 YP_001173810.1 Code: S; COG: COG1556 YP_001173816.1 Code: L; COG: COG2801 YP_001173817.1 Code: L; COG: COG2801 YP_001173819.1 Code: L; COG: COG0389 YP_001173820.1 Code: S; COG: COG1917 YP_001173825.1 Code: KT; COG: COG1974 YP_001173826.1 Code: S; COG: COG2135 YP_001173827.1 Code: K; COG: COG0583 YP_001173828.1 Code: C; COG: COG0667 YP_001173831.1 Code: P; COG: COG3696 YP_001173832.1 Code: M; COG: COG0845 YP_001173838.1 Code: S; COG: COG4828 YP_001173847.1 Code: L; COG: COG3436 YP_001173848.1 Code: L; COG: COG3436 YP_001173851.1 Code: P; COG: COG3667 YP_001173853.1 Code: Q; COG: COG2132 YP_001173854.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001173855.1 Code: R; COG: COG3019 YP_001173856.1 Code: P; COG: COG2608 YP_001173857.1 Code: P; COG: COG2217 YP_001173860.1 Code: TK; COG: COG0745 YP_001173861.1 Code: T; COG: COG0642 YP_001173865.1 Code: L; COG: COG4584 YP_001173866.1 Code: L; COG: COG1484 YP_001173869.1 Code: L; COG: COG3344 YP_001173873.1 Code: L; COG: COG2963 YP_001173874.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001173875.1 Code: I; COG: COG1267 YP_001173876.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001173877.1 Code: L; COG: COG0582 YP_001173879.1 Code: L; COG: COG4584 YP_001173880.1 Code: L; COG: COG1484 YP_001173886.1 Code: P; COG: COG1230 YP_001173887.1 Code: K; COG: COG0789 YP_001173888.1 Code: T; COG: COG0642 YP_001173889.1 Code: L; COG: COG2826 YP_001173890.1 Code: T; COG: COG0642 YP_001173891.1 Code: TK; COG: COG0745 YP_001173893.1 Code: MU; COG: COG1538 YP_001173894.1 Code: M; COG: COG0845 YP_001173898.1 Code: P; COG: COG1230 YP_001173901.1 Code: K; COG: COG0789 YP_001173906.1 Code: R; COG: COG1569 YP_001173910.1 Code: L; COG: COG0210 YP_001173917.1 Code: V; COG: COG1002 YP_001173918.1 Code: KL; COG: COG0553 YP_001173921.1 Code: K; COG: COG2378 YP_001173925.1 Code: O; COG: COG0464 YP_001173930.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation YP_001173931.1 Code: R; COG: COG1201 YP_001173934.1 Code: R; COG: COG5018 YP_001173941.1 Code: L; COG: COG3436 YP_001173942.1 Code: L; COG: COG3436 YP_001173945.1 Code: LR; COG: COG0494 YP_001173946.1 Code: E; COG: COG1280 YP_001173948.1 with malEFG is involved in import of maltose/maltodextrin YP_001173949.1 Code: G; COG: COG0366 YP_001173950.1 Code: R; COG: COG0110 YP_001173951.1 Code: O; COG: COG0625 YP_001173953.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001173954.1 with MalKFE is involved in the transport of maltose into the cell YP_001173955.1 with MalKGE is involved in maltose transport into the cell YP_001173956.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001173957.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_001173960.1 porin involved in the transport of maltose and maltodextrins YP_001173962.1 Code: P; COG: COG2076 YP_001173963.1 Code: R; COG: COG4989 YP_001173964.1 Code: C; COG: COG1012 YP_001173965.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001173966.1 Code: G; COG: COG0363 YP_001173967.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001173968.1 Represses the expression of the zwf, eda, glp and gap YP_001173969.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001173970.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001173972.1 Code: GEPR; COG: COG0477 YP_001173973.1 Code: P; COG: COG3470 YP_001173975.1 Code: P; COG: COG0672 YP_001173976.1 Code: C; COG: COG0348 YP_001173977.1 Code: O; COG: COG1180 YP_001173979.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001173980.1 Code: T; COG: COG0664 YP_001173981.1 Code: S; COG: COG4273 YP_001173982.1 Code: O; COG: COG0826 YP_001173983.1 Code: O; COG: COG0826 YP_001173985.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_001173986.1 Code: D; COG: COG2846 YP_001173988.1 Code: T; COG: COG0664 YP_001173990.1 Code: P; COG: COG4548 YP_001173991.1 Code: P; COG: COG3256 YP_001173992.1 Code: C; COG: COG2010 YP_001173993.1 Code: K; COG: COG1522 YP_001173994.1 Code: K; COG: COG1522 YP_001173995.1 Code: K; COG: COG1522 YP_001173996.1 Code: K; COG: COG1522 YP_001173998.1 Code: C; COG: COG2010 YP_001173999.1 Code: C; COG: COG4654 YP_001174001.1 Code: C; COG: COG3005 YP_001174003.1 Code: R; COG: COG0714 YP_001174004.1 Code: C; COG: COG1845 YP_001174006.1 Code: R; COG: COG0535 YP_001174007.1 Code: H; COG: COG0007 YP_001174009.1 Code: K; COG: COG0583 YP_001174010.1 Code: T; COG: COG3448 YP_001174012.1 Code: NT; COG: COG0840 YP_001174013.1 Code: IQR; COG: COG1028 YP_001174014.1 Code: P; COG: COG3213 YP_001174016.1 Code: C; COG: COG4314 YP_001174017.1 Code: R; COG: COG1277 YP_001174018.1 Code: V; COG: COG1131 YP_001174019.1 Code: P; COG: COG3420 YP_001174020.1 reduces nitrous oxide to nitrogen YP_001174021.1 Code: K; COG: COG3901 YP_001174022.1 Code: I; COG: COG1960 YP_001174023.1 Code: S; COG: COG3399 YP_001174025.1 Code: S; COG: COG3189 YP_001174026.1 Code: G; COG: COG1638 YP_001174027.1 Code: G; COG: COG1638 YP_001174028.1 Code: O; COG: COG0492 YP_001174029.1 Code: E; COG: COG1760 YP_001174031.1 Code: KE; COG: COG3283 YP_001174032.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_001174033.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_001174034.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001174036.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide YP_001174037.1 Code: R; COG: COG0666 YP_001174038.1 Code: P; COG: COG0753 YP_001174039.1 Code: F; COG: COG1457 YP_001174040.1 Code: FR; COG: COG0402 YP_001174041.1 Code: C; COG: COG2863 YP_001174043.1 Code: I; COG: COG1607 YP_001174044.1 Code: P; COG: COG2824 YP_001174045.1 Code: S; COG: COG3326 YP_001174046.1 Code: S; COG: COG1432 YP_001174049.1 Code: R; COG: COG1079 YP_001174050.1 Code: R; COG: COG4603 YP_001174052.1 Code: R; COG: COG1744 YP_001174054.1 Code: R; COG: COG3491 YP_001174056.1 Code: S; COG: COG4244 YP_001174057.1 Code: G; COG: COG2133 YP_001174059.1 Code: E; COG: COG0346 YP_001174061.1 Code: S; COG: COG2128 YP_001174062.1 Code: K; COG: COG2207 YP_001174063.1 Code: K; COG: COG4977 YP_001174064.1 Code: GEPR; COG: COG0477 YP_001174066.1 Code: K; COG: COG1309 YP_001174067.1 Code: C; COG: COG2141 YP_001174068.1 Code: Q; COG: COG1335 YP_001174069.1 Code: J; COG: COG0251 YP_001174070.1 Code: R; COG: COG0596 YP_001174071.1 Code: C; COG: COG0778 YP_001174072.1 Code: R; COG: COG1853 YP_001174073.1 Code: T; COG: COG1734 YP_001174074.1 Code: R; COG: COG0523 YP_001174076.1 Code: C; COG: COG1145 YP_001174077.1 Code: S; COG: COG1739 YP_001174078.1 catalyzes the formation of inosine from adenosine YP_001174080.1 Code: GEPR; COG: COG0477 YP_001174081.1 Code: K; COG: COG1309 YP_001174082.1 Code: P; COG: COG2608 YP_001174083.1 Code: P; COG: COG2217 YP_001174084.1 Code: K; COG: COG0789 YP_001174085.1 Code: NT; COG: COG0840 YP_001174086.1 Code: P; COG: COG2193 YP_001174088.1 Code: V; COG: COG0841 YP_001174089.1 Code: MU; COG: COG1538 YP_001174090.1 Code: TD; COG: COG1718 YP_001174093.1 Code: L; COG: COG0084 YP_001174094.1 Code: NT; COG: COG0840 YP_001174095.1 Code: V; COG: COG3725 YP_001174096.1 Code: V; COG: COG3023 YP_001174097.1 Code: L; COG: COG1515 YP_001174098.1 Code: K; COG: COG4977 YP_001174099.1 Code: R; COG: COG1485 YP_001174100.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001174101.1 Code: R; COG: COG2945 YP_001174102.1 Code: S; COG: COG3105 YP_001174103.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001174105.1 Code: C; COG: COG1252 YP_001174107.1 Code: O; COG: COG0542 YP_001174108.1 Code: S; COG: COG1496 YP_001174109.1 Code: J; COG: COG0564 YP_001174110.1 Code: R; COG: COG4105 YP_001174112.1 Code: T; COG: COG0642 YP_001174113.1 Code: T; COG: COG2204 YP_001174114.1 Code: S; COG: COG5345 YP_001174115.1 Code: T; COG: COG3706 YP_001174116.1 Code: NT; COG: COG0840 YP_001174117.1 Code: C; COG: COG1032 YP_001174118.1 Code: M; COG: COG0787 YP_001174119.1 unwinds double stranded DNA YP_001174120.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001174122.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001174123.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001174125.1 Code: J; COG: COG0566 YP_001174126.1 Code: K; COG: COG0557 YP_001174128.1 Code: F; COG: COG0104 YP_001174129.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_001174130.1 Code: O; COG: COG0330 YP_001174131.1 Code: O; COG: COG0330 YP_001174132.1 Code: R; COG: COG2262 YP_001174133.1 Stimulates the elongation of poly(A) tails YP_001174134.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001174135.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001174136.1 Code: M; COG: COG0860 YP_001174137.1 Code: R; COG: COG0802 YP_001174139.1 Code: C; COG: COG1600 YP_001174140.1 Code: O; COG: COG0465 YP_001174141.1 Code: R; COG: COG5645 YP_001174142.1 Code: H; COG: COG0163 YP_001174143.1 Code: M; COG: COG0773 YP_001174144.1 Code: C; COG: COG1012 YP_001174145.1 Code: E; COG: COG0531 YP_001174146.1 Code: E; COG: COG4303 YP_001174147.1 catalyzes the formation of acetaldehyde from ethanolamine YP_001174148.1 Code: P; COG: COG3540 YP_001174149.1 Code: J; COG: COG0251 YP_001174150.1 Code: S; COG: COG3228 YP_001174151.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001174154.1 Code: P; COG: COG0715 YP_001174158.1 Code: C; COG: COG0243 YP_001174160.1 Code: C; COG: COG0437 YP_001174161.1 Code: OC; COG: COG0526 YP_001174163.1 Code: E; COG: COG0076 YP_001174164.1 Code: Q; COG: COG3486 YP_001174166.1 Code: J; COG: COG1670 YP_001174167.1 Code: Q; COG: COG4264 YP_001174169.1 Code: L; COG: COG1722 YP_001174170.1 Code: H; COG: COG0142 YP_001174171.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001174172.1 Code: S; COG: COG1432 YP_001174174.1 Code: E; COG: COG0346 YP_001174175.1 Code: IQR; COG: COG1028 YP_001174177.1 Code: L; COG: COG1643 YP_001174180.1 Code: P; COG: COG0053 YP_001174181.1 Code: K; COG: COG1522 YP_001174184.1 Code: J; COG: COG1187 YP_001174185.1 Code: E; COG: COG0683 YP_001174186.1 Code: E; COG: COG0559 YP_001174187.1 Code: E; COG: COG4177 YP_001174188.1 Code: R; COG: COG4674 YP_001174189.1 Code: E; COG: COG0410 YP_001174190.1 Code: P; COG: COG0474 YP_001174191.1 Code: O; COG: COG0829 YP_001174192.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001174193.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_001174194.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001174196.1 Code: T; COG: COG1734 YP_001174198.1 Code: G; COG: COG2513 YP_001174199.1 Code: GER; COG: COG0697 YP_001174201.2 involved in the assembly of the urease metallocenter; possible nickel donor YP_001174202.1 Code: O; COG: COG0830 YP_001174203.1 Code: OK; COG: COG0378 YP_001174204.1 Code: O; COG: COG2370 YP_001174206.1 Code: G; COG: COG4993 YP_001174207.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001174208.1 Code: KE; COG: COG1167 YP_001174209.1 Code: E; COG: COG1171 YP_001174210.1 Code: R; COG: COG1203 YP_001174213.1 Code: L; COG: COG3649 YP_001174214.1 Code: L; COG: COG1468 YP_001174215.1 Code: L; COG: COG1518 YP_001174216.1 Code: L; COG: COG1343 YP_001174218.1 Code: P; COG: COG1226 YP_001174219.1 Code: I; COG: COG1960 YP_001174221.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001174222.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001174223.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001174225.1 Code: R; COG: COG0790 YP_001174226.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001174227.1 Code: T; COG: COG1702 YP_001174228.1 Code: R; COG: COG0319 YP_001174229.1 Code: P; COG: COG4535 YP_001174230.1 Transfers the fatty acyl group on membrane lipoproteins YP_001174231.1 Code: S; COG: COG1434 YP_001174233.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001174234.1 Code: M; COG: COG2980 YP_001174235.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001174236.1 Code: S; COG: COG3036 YP_001174237.1 Code: M; COG: COG2951 YP_001174239.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001174240.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001174241.1 Code: S; COG: COG2921 YP_001174242.1 Code: M; COG: COG1686 YP_001174243.1 Code: M; COG: COG0797 YP_001174244.1 Code: M; COG: COG2951 YP_001174245.1 Code: D; COG: COG0772 YP_001174246.1 Code: M; COG: COG0768 YP_001174247.2 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001174248.1 Code: S; COG: COG0799 YP_001174249.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001174250.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001174252.1 Code: R; COG: COG2802 YP_001174253.1 Code: M; COG: COG1346 YP_001174254.1 Code: R; COG: COG1380 YP_001174255.1 Code: I; COG: COG2030 YP_001174256.1 Code: S; COG: COG4642 YP_001174257.1 Code: MG; COG: COG0702 YP_001174258.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001174260.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001174261.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001174262.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001174264.1 Code: P; COG: COG2897 YP_001174265.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001174268.1 Code: ER; COG: COG1063 YP_001174271.1 Code: S; COG: COG3009 YP_001174272.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001174273.1 Code: R; COG: COG3577 YP_001174275.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001174276.1 Code: R; COG: COG3150 YP_001174277.1 Code: R; COG: COG1409 YP_001174278.1 Code: S; COG: COG3151 YP_001174279.1 Code: LR; COG: COG0494 YP_001174281.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001174282.1 Code: MU; COG: COG1538 YP_001174283.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001174284.1 Code: P; COG: COG2076 YP_001174285.1 Code: C; COG: COG0578 YP_001174286.1 Code: C; COG: COG0667 YP_001174288.1 related to capsule biosynthesis enzyme; Code: R; COG: COG3550 YP_001174290.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001174295.1 Code: V; COG: COG1132 YP_001174300.1 Code: M; COG: COG2089 YP_001174301.1 Code: J; COG: COG1670 YP_001174302.1 Code: M; COG: COG3980 YP_001174303.1 Code: M; COG: COG1083 YP_001174304.1 Code: M; COG: COG0399 YP_001174305.1 Code: MG; COG: COG1086 YP_001174307.1 Code: O; COG: COG2192 YP_001174312.1 Code: M; COG: COG0438 YP_001174313.1 Code: M; COG: COG0859 YP_001174314.1 Code: M; COG: COG0859 YP_001174315.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001174316.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001174317.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001174318.1 Code: C; COG: COG0508 YP_001174321.1 Code: O; COG: COG0225 YP_001174323.1 Code: I; COG: COG1960 YP_001174324.1 Code: T; COG: COG2199 YP_001174325.1 Code: I; COG: COG1960 YP_001174327.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001174328.1 Code: QR; COG: COG0500 YP_001174329.1 Code: R; COG: COG0596 YP_001174330.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001174331.1 Code: H; COG: COG0502 YP_001174332.1 Code: R; COG: COG1040 YP_001174333.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_001174334.1 Code: R; COG: COG2961 YP_001174335.1 Code: R; COG: COG2070 YP_001174337.1 Code: I; COG: COG1562 YP_001174338.1 Code: Q; COG: COG1233 YP_001174340.1 Code: GC; COG: COG1819 YP_001174341.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001174342.1 Code: H; COG: COG0142 YP_001174343.1 Code: I; COG: COG1960 YP_001174344.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001174345.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001174346.1 Code: S; COG: COG0397 YP_001174347.1 Code: T; COG: COG0642 YP_001174348.1 Code: NT; COG: COG2201 YP_001174349.1 Code: NT; COG: COG1352 YP_001174351.1 Code: S; COG: COG0401 YP_001174354.1 Code: R; COG: COG0491 YP_001174355.1 Code: O; COG: COG1030 YP_001174356.1 Code: O; COG: COG0330 YP_001174359.1 Code: G; COG: COG1626 YP_001174360.1 Code: IQR; COG: COG1028 YP_001174361.1 Code: R; COG: COG2962 YP_001174362.1 Code: E; COG: COG2716 YP_001174363.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_001174365.1 Code: L; COG: COG0847 YP_001174367.1 Code: R; COG: COG4147 YP_001174369.1 Code: O; COG: COG4067 YP_001174370.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_001174371.1 Code: S; COG: COG1289 YP_001174373.1 Code: R; COG: COG2081 YP_001174376.1 Code: T; COG: COG5001 YP_001174379.1 Code: QR; COG: COG0500 YP_001174380.1 Code: T; COG: COG0784 YP_001174381.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_001174383.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001174384.1 Code: G; COG: COG0057 YP_001174385.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001174386.1 Code: K; COG: COG0583 YP_001174390.1 Code: QR; COG: COG0500 YP_001174391.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001174393.1 Code: V; COG: COG0842 YP_001174394.1 Code: V; COG: COG1131 YP_001174395.1 Code: P; COG: COG4097 YP_001174396.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_001174398.1 Code: C; COG: COG3909 YP_001174400.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001174401.1 Code: E; COG: COG0685 YP_001174402.1 Code: LKJ; COG: COG0513 YP_001174403.1 Code: MU; COG: COG1538 YP_001174404.1 Code: V; COG: COG0841 YP_001174405.1 Code: M; COG: COG0845 YP_001174406.1 Code: S; COG: COG2353 YP_001174407.1 Code: C; COG: COG3038 YP_001174409.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001174410.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001174412.1 Code: NT; COG: COG2201 YP_001174414.1 Code: NT; COG: COG1352 YP_001174415.1 Code: NT; COG: COG0840 YP_001174416.1 Code: NT; COG: COG0835 YP_001174417.1 Code: T; COG: COG0784 YP_001174418.1 Code: T; COG: COG0784 YP_001174419.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001174420.1 Code: M; COG: COG0810 YP_001174421.1 Code: K; COG: COG1678 YP_001174422.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001174423.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001174424.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001174425.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001174427.1 Code: R; COG: COG4277 YP_001174429.1 Code: NU; COG: COG5008 YP_001174430.1 Code: NU; COG: COG2805 YP_001174431.1 Code: R; COG: COG0325 YP_001174432.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001174433.1 Code: S; COG: COG0762 YP_001174434.1 Code: R; COG: COG0699 YP_001174435.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_001174436.1 Code: QR; COG: COG0500 YP_001174438.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001174439.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001174442.1 Code: E; COG: COG0531 YP_001174443.1 catalyzes the degradation of arginine to citruline and ammonia YP_001174444.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001174445.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001174447.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001174448.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001174449.1 Code: H; COG: COG2104 YP_001174450.1 Code: S; COG: COG2363 YP_001174451.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001174454.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001174455.1 Code: D; COG: COG2177 YP_001174456.1 Code: D; COG: COG2884 YP_001174457.1 Code: U; COG: COG0552 YP_001174458.1 Code: R; COG: COG0612 YP_001174459.1 Code: R; COG: COG0612 YP_001174460.1 Code: L; COG: COG0742 YP_001174462.1 Code: R; COG: COG0429 YP_001174463.1 Code: K; COG: COG1309 YP_001174464.1 Code: C; COG: COG1012 YP_001174466.1 Code: E; COG: COG2303 YP_001174467.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001174468.1 Code: C; COG: COG1145 YP_001174469.1 Code: E; COG: COG0405 YP_001174470.1 Code: P; COG: COG1283 YP_001174472.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001174473.1 Code: T; COG: COG1639 YP_001174474.1 Code: R; COG: COG0693 YP_001174475.1 Code: R; COG: COG1092 YP_001174477.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001174479.1 Code: R; COG: COG0579 YP_001174480.1 Code: R; COG: COG0622 YP_001174481.1 Code: S; COG: COG1284 YP_001174482.1 Code: H; COG: COG0262 YP_001174483.1 Code: C; COG: COG0584 YP_001174487.1 Code: K; COG: COG0583 YP_001174488.1 Code: P; COG: COG0704 YP_001174489.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001174491.1 Code: R; COG: COG4590 YP_001174492.1 Code: P; COG: COG0226 YP_001174493.1 Code: I; COG: COG1607 YP_001174494.1 Code: T; COG: COG2199 YP_001174495.1 Code: R; COG: COG0679 YP_001174497.1 Code: L; COG: COG0507 YP_001174498.1 Code: L; COG: COG1074 YP_001174499.1 Code: L; COG: COG1330 YP_001174501.1 Code: P; COG: COG1283 YP_001174502.1 Code: R; COG: COG3180 YP_001174503.1 Code: S; COG: COG3333 YP_001174505.1 Code: S; COG: COG3181 YP_001174507.1 Code: TK; COG: COG0745 YP_001174508.1 Code: T; COG: COG0642 YP_001174510.1 Code: NT; COG: COG0840 YP_001174512.1 Code: NT; COG: COG0840 YP_001174513.1 Code: R; COG: COG2358 YP_001174514.1 Code: R; COG: COG4666 YP_001174518.1 Code: T; COG: COG2204 YP_001174519.1 Code: T; COG: COG0642 YP_001174521.1 Code: V; COG: COG3023 YP_001174522.1 Code: T; COG: COG2199 YP_001174523.1 Code: R; COG: COG3568 YP_001174524.1 Code: OC; COG: COG0526 YP_001174525.1 Code: C; COG: COG2863 YP_001174526.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001174527.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001174528.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001174529.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001174530.1 Code: P; COG: COG1178 YP_001174531.1 Code: P; COG: COG1840 YP_001174532.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol YP_001174533.1 translation initiation factor 5A (eIF-5A) YP_001174534.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001174535.1 Code: E; COG: COG0006 YP_001174536.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001174538.1 Code: H; COG: COG0212 YP_001174540.1 Code: N; COG: COG1580 YP_001174541.1 Code: CR; COG: COG0604 YP_001174542.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001174543.1 Code: O; COG: COG0695 YP_001174544.1 Code: P; COG: COG0607 YP_001174545.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001174546.1 Code: D; COG: COG4942 YP_001174547.1 Code: M; COG: COG0793 YP_001174548.1 Code: S; COG: COG2861 YP_001174549.1 Code: ET; COG: COG0834 YP_001174551.1 Code: ET; COG: COG0834 YP_001174552.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001174553.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001174555.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001174557.1 Code: P; COG: COG0715 YP_001174558.1 Code: P; COG: COG0600 YP_001174559.1 Code: P; COG: COG1116 YP_001174561.1 Code: M; COG: COG2982 YP_001174562.1 Code: L; COG: COG1194 YP_001174563.1 Code: CO; COG: COG2924 YP_001174564.1 Code: L; COG: COG1525 YP_001174566.1 Code: M; COG: COG1292 YP_001174567.1 Code: E; COG: COG4598 YP_001174568.1 Code: ET; COG: COG0834 YP_001174569.1 Code: E; COG: COG4215 YP_001174570.1 Code: E; COG: COG4160 YP_001174571.1 Code: G; COG: COG0676 YP_001174573.1 Code: K; COG: COG0583 YP_001174574.1 catalyzes the oxidative deamination of D-amino acids YP_001174575.1 Code: NT; COG: COG0840 YP_001174578.1 Code: I; COG: COG0331 YP_001174579.1 Catalyzes the transfer of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-acyl carrier protein of malonate dehydrogenase to form holo-acyl carrier protein YP_001174581.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A YP_001174582.1 acyl carrier protein of malonate decarboxylase YP_001174583.1 catalyzes the reversible formation of 2'-(5''-triphosphoribosyl)-3'dephospho-CoA from 3-dephospho-CoA YP_001174585.1 Code: R; COG: COG4221 YP_001174586.1 Code: P; COG: COG3709 YP_001174588.1 Code: R; COG: COG2358 YP_001174589.1 Code: R; COG: COG4666 YP_001174590.1 Code: S; COG: COG4729 YP_001174594.1 Code: R; COG: COG4324 YP_001174597.1 Code: C; COG: COG2141 YP_001174598.1 Code: P; COG: COG0025 YP_001174599.1 Code: S; COG: COG3360 YP_001174600.1 Code: O; COG: COG0625 YP_001174604.1 Code: F; COG: COG0737 YP_001174607.1 Code: E; COG: COG3340 YP_001174608.1 Code: V; COG: COG1132 YP_001174609.1 Code: R; COG: COG1752 YP_001174610.1 Code: S; COG: COG3812 YP_001174613.1 Code: K; COG: COG0583 YP_001174616.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001174617.1 Code: R; COG: COG1064 YP_001174618.1 Code: R; COG: COG3565 YP_001174619.1 Code: R; COG: COG0663 YP_001174620.1 Code: E; COG: COG0339 YP_001174622.1 Code: I; COG: COG1835 YP_001174623.1 Code: L; COG: COG1533 YP_001174624.1 Code: P; COG: COG0288 YP_001174625.1 Code: P; COG: COG0659 YP_001174627.1 Code: C; COG: COG1622 YP_001174628.1 Code: C; COG: COG0843 YP_001174629.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_001174630.1 Code: C; COG: COG1845 YP_001174632.1 Code: S; COG: COG3346 YP_001174634.1 Code: O; COG: COG1612 YP_001174635.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001174636.1 Code: R; COG: COG1999 YP_001174637.1 Code: S; COG: COG3182 YP_001174638.1 Code: P; COG: COG1629 YP_001174639.1 Code: PT; COG: COG3712 YP_001174640.1 Code: K; COG: COG1595 YP_001174643.1 Code: R; COG: COG0523 YP_001174646.1 Code: T; COG: COG4251 YP_001174647.1 Code: T; COG: COG0784 YP_001174649.1 Code: P; COG: COG3230 YP_001174650.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001174651.1 Code: KG; COG: COG1349 YP_001174652.1 Code: E; COG: COG1280 YP_001174653.1 Code: M; COG: COG1207 YP_001174654.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001174655.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001174656.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001174657.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001174658.1 Code: C; COG: COG0712 YP_001174659.1 Code: C; COG: COG0711 YP_001174660.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001174661.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001174662.1 Code: C; COG: COG3312 YP_001174663.1 Code: K; COG: COG1475 YP_001174664.1 Code: D; COG: COG1192 YP_001174665.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001174666.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001174667.1 Code: P; COG: COG1320 YP_001174668.1 Code: P; COG: COG2212 YP_001174669.1 Code: P; COG: COG1863 YP_001174670.1 Code: CP; COG: COG0651 YP_001174671.1 Code: P; COG: COG1006 YP_001174673.1 Code: CP; COG: COG1009 YP_001174674.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001174675.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001174676.1 Code: S; COG: COG0759 YP_001174677.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001174678.1 in Escherichia coli transcription of this gene is enhanced by polyamines