-- dump date   	20140620_015945
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
644801000001	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
644801000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
644801000003	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
644801000004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801000005	Walker A motif; other site
644801000006	ATP binding site [chemical binding]; other site
644801000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
644801000008	Walker B motif; other site
644801000009	arginine finger; other site
644801000010	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
644801000011	DnaA box-binding interface [nucleotide binding]; other site
644801000012	DNA polymerase III subunit beta; Validated; Region: PRK05643
644801000013	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
644801000014	putative DNA binding surface [nucleotide binding]; other site
644801000015	dimer interface [polypeptide binding]; other site
644801000016	beta-clamp/clamp loader binding surface; other site
644801000017	beta-clamp/translesion DNA polymerase binding surface; other site
644801000018	recombination protein F; Reviewed; Region: recF; PRK00064
644801000019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801000020	Walker A/P-loop; other site
644801000021	ATP binding site [chemical binding]; other site
644801000022	Q-loop/lid; other site
644801000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801000024	ABC transporter signature motif; other site
644801000025	Walker B; other site
644801000026	D-loop; other site
644801000027	H-loop/switch region; other site
644801000028	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
644801000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801000030	ATP binding site [chemical binding]; other site
644801000031	Mg2+ binding site [ion binding]; other site
644801000032	G-X-G motif; other site
644801000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
644801000034	anchoring element; other site
644801000035	dimer interface [polypeptide binding]; other site
644801000036	ATP binding site [chemical binding]; other site
644801000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
644801000038	active site
644801000039	putative metal-binding site [ion binding]; other site
644801000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
644801000041	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
644801000042	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
644801000043	catalytic residue [active]
644801000044	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
644801000045	catalytic residues [active]
644801000046	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801000047	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801000048	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
644801000049	heme-binding site [chemical binding]; other site
644801000050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801000051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801000052	metal binding site [ion binding]; metal-binding site
644801000053	active site
644801000054	I-site; other site
644801000055	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
644801000056	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
644801000057	putative acyl-acceptor binding pocket; other site
644801000058	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
644801000059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801000060	active site
644801000061	motif I; other site
644801000062	motif II; other site
644801000063	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
644801000064	HD domain; Region: HD; pfam01966
644801000065	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
644801000066	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
644801000067	dimer interface [polypeptide binding]; other site
644801000068	motif 1; other site
644801000069	active site
644801000070	motif 2; other site
644801000071	motif 3; other site
644801000072	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
644801000073	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
644801000074	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
644801000075	putative acyl-acceptor binding pocket; other site
644801000076	PilZ domain; Region: PilZ; pfam07238
644801000077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801000078	TPR motif; other site
644801000079	Tetratricopeptide repeat; Region: TPR_16; pfam13432
644801000080	binding surface
644801000081	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
644801000082	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
644801000083	Walker A/P-loop; other site
644801000084	ATP binding site [chemical binding]; other site
644801000085	Q-loop/lid; other site
644801000086	ABC transporter signature motif; other site
644801000087	Walker B; other site
644801000088	D-loop; other site
644801000089	H-loop/switch region; other site
644801000090	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
644801000091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000092	dimer interface [polypeptide binding]; other site
644801000093	conserved gate region; other site
644801000094	putative PBP binding loops; other site
644801000095	ABC-ATPase subunit interface; other site
644801000096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000097	dimer interface [polypeptide binding]; other site
644801000098	conserved gate region; other site
644801000099	putative PBP binding loops; other site
644801000100	ABC-ATPase subunit interface; other site
644801000101	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
644801000102	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801000103	substrate binding pocket [chemical binding]; other site
644801000104	membrane-bound complex binding site; other site
644801000105	hinge residues; other site
644801000106	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
644801000107	TrkA-N domain; Region: TrkA_N; pfam02254
644801000108	TrkA-C domain; Region: TrkA_C; pfam02080
644801000109	TrkA-N domain; Region: TrkA_N; pfam02254
644801000110	TrkA-C domain; Region: TrkA_C; pfam02080
644801000111	16S rRNA methyltransferase B; Provisional; Region: PRK10901
644801000112	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
644801000113	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
644801000114	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
644801000115	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
644801000116	putative active site [active]
644801000117	substrate binding site [chemical binding]; other site
644801000118	putative cosubstrate binding site; other site
644801000119	catalytic site [active]
644801000120	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
644801000121	substrate binding site [chemical binding]; other site
644801000122	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
644801000123	active site
644801000124	catalytic residues [active]
644801000125	metal binding site [ion binding]; metal-binding site
644801000126	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
644801000127	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801000128	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
644801000129	DNA protecting protein DprA; Region: dprA; TIGR00732
644801000130	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
644801000131	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
644801000132	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
644801000133	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
644801000134	NADP binding site [chemical binding]; other site
644801000135	dimer interface [polypeptide binding]; other site
644801000136	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
644801000137	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
644801000138	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
644801000139	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
644801000140	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
644801000141	shikimate binding site; other site
644801000142	NAD(P) binding site [chemical binding]; other site
644801000143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801000144	NADH(P)-binding; Region: NAD_binding_10; pfam13460
644801000145	NAD(P) binding site [chemical binding]; other site
644801000146	active site
644801000147	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
644801000148	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
644801000149	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
644801000150	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
644801000151	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801000152	N-terminal plug; other site
644801000153	ligand-binding site [chemical binding]; other site
644801000154	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
644801000155	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
644801000156	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
644801000157	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
644801000158	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
644801000159	phosphoglucomutase; Validated; Region: PRK07564
644801000160	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
644801000161	active site
644801000162	substrate binding site [chemical binding]; other site
644801000163	metal binding site [ion binding]; metal-binding site
644801000164	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
644801000165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
644801000166	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
644801000167	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801000168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801000169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801000170	dimerization interface [polypeptide binding]; other site
644801000171	Predicted membrane protein [Function unknown]; Region: COG2323
644801000172	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
644801000173	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
644801000174	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
644801000175	active site
644801000176	nucleophile elbow; other site
644801000177	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
644801000178	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
644801000179	Walker A/P-loop; other site
644801000180	ATP binding site [chemical binding]; other site
644801000181	Q-loop/lid; other site
644801000182	ABC transporter signature motif; other site
644801000183	Walker B; other site
644801000184	D-loop; other site
644801000185	H-loop/switch region; other site
644801000186	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
644801000187	putative hydrophobic ligand binding site [chemical binding]; other site
644801000188	Predicted acetyltransferase [General function prediction only]; Region: COG2388
644801000189	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
644801000190	Predicted membrane protein [Function unknown]; Region: COG3918
644801000191	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801000192	putative S-transferase; Provisional; Region: PRK11752
644801000193	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
644801000194	C-terminal domain interface [polypeptide binding]; other site
644801000195	GSH binding site (G-site) [chemical binding]; other site
644801000196	dimer interface [polypeptide binding]; other site
644801000197	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
644801000198	dimer interface [polypeptide binding]; other site
644801000199	N-terminal domain interface [polypeptide binding]; other site
644801000200	active site
644801000201	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801000202	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
644801000203	non-specific DNA binding site [nucleotide binding]; other site
644801000204	salt bridge; other site
644801000205	sequence-specific DNA binding site [nucleotide binding]; other site
644801000206	HipA-like N-terminal domain; Region: HipA_N; pfam07805
644801000207	HipA-like C-terminal domain; Region: HipA_C; pfam07804
644801000208	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
644801000209	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
644801000210	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
644801000211	substrate binding site [chemical binding]; other site
644801000212	active site
644801000213	catalytic residues [active]
644801000214	heterodimer interface [polypeptide binding]; other site
644801000215	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
644801000216	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
644801000217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801000218	catalytic residue [active]
644801000219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801000220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801000221	dimerization interface [polypeptide binding]; other site
644801000222	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
644801000223	catalytic triad [active]
644801000224	putative active site [active]
644801000225	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
644801000226	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
644801000227	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
644801000228	conserved cys residue [active]
644801000229	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801000230	Isochorismatase family; Region: Isochorismatase; pfam00857
644801000231	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
644801000232	catalytic triad [active]
644801000233	conserved cis-peptide bond; other site
644801000234	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
644801000235	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
644801000236	NAD binding site [chemical binding]; other site
644801000237	homodimer interface [polypeptide binding]; other site
644801000238	active site
644801000239	substrate binding site [chemical binding]; other site
644801000240	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
644801000241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801000242	putative homodimer interface [polypeptide binding]; other site
644801000243	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
644801000244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801000245	UDP-galactopyranose mutase; Region: GLF; pfam03275
644801000246	beta-galactosidase; Region: BGL; TIGR03356
644801000247	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
644801000248	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
644801000249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801000250	Walker A/P-loop; other site
644801000251	ATP binding site [chemical binding]; other site
644801000252	Q-loop/lid; other site
644801000253	ABC transporter signature motif; other site
644801000254	Walker B; other site
644801000255	D-loop; other site
644801000256	H-loop/switch region; other site
644801000257	KTSC domain; Region: KTSC; pfam13619
644801000258	Dodecin; Region: Dodecin; pfam07311
644801000259	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
644801000260	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
644801000261	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
644801000262	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
644801000263	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
644801000264	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
644801000265	Ferritin-like domain; Region: Ferritin; pfam00210
644801000266	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
644801000267	dinuclear metal binding motif [ion binding]; other site
644801000268	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
644801000269	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
644801000270	DctM-like transporters; Region: DctM; pfam06808
644801000271	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
644801000272	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
644801000273	putative hydrolase; Provisional; Region: PRK02113
644801000274	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
644801000275	Guanylate kinase; Region: Guanylate_kin; pfam00625
644801000276	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
644801000277	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
644801000278	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
644801000279	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
644801000280	active site
644801000281	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
644801000282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801000283	Walker A/P-loop; other site
644801000284	ATP binding site [chemical binding]; other site
644801000285	Q-loop/lid; other site
644801000286	ABC transporter signature motif; other site
644801000287	Walker B; other site
644801000288	D-loop; other site
644801000289	H-loop/switch region; other site
644801000290	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
644801000291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801000292	Walker A/P-loop; other site
644801000293	ATP binding site [chemical binding]; other site
644801000294	Q-loop/lid; other site
644801000295	ABC transporter signature motif; other site
644801000296	Walker B; other site
644801000297	D-loop; other site
644801000298	H-loop/switch region; other site
644801000299	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
644801000300	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
644801000301	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
644801000302	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
644801000303	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
644801000304	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
644801000305	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801000306	DNA-binding site [nucleotide binding]; DNA binding site
644801000307	UTRA domain; Region: UTRA; pfam07702
644801000308	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
644801000309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000310	dimer interface [polypeptide binding]; other site
644801000311	conserved gate region; other site
644801000312	ABC-ATPase subunit interface; other site
644801000313	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
644801000314	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
644801000315	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
644801000316	Walker A/P-loop; other site
644801000317	ATP binding site [chemical binding]; other site
644801000318	Q-loop/lid; other site
644801000319	ABC transporter signature motif; other site
644801000320	Walker B; other site
644801000321	D-loop; other site
644801000322	H-loop/switch region; other site
644801000323	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
644801000324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801000325	NAD(P) binding site [chemical binding]; other site
644801000326	active site
644801000327	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
644801000328	Coenzyme A transferase; Region: CoA_trans; cl17247
644801000329	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
644801000330	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
644801000331	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
644801000332	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
644801000333	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
644801000334	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
644801000335	active site
644801000336	NTP binding site [chemical binding]; other site
644801000337	metal binding triad [ion binding]; metal-binding site
644801000338	antibiotic binding site [chemical binding]; other site
644801000339	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
644801000340	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
644801000341	Malonate transporter MadL subunit; Region: MadL; cl04273
644801000342	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
644801000343	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
644801000344	hydroxyglutarate oxidase; Provisional; Region: PRK11728
644801000345	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801000346	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801000347	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
644801000348	putative dimerization interface [polypeptide binding]; other site
644801000349	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
644801000350	RNA polymerase sigma factor; Provisional; Region: PRK12536
644801000351	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
644801000352	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
644801000353	hypothetical protein; Provisional; Region: PRK05409
644801000354	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
644801000355	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
644801000356	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801000357	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
644801000358	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
644801000359	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
644801000360	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
644801000361	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
644801000362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801000363	Walker A motif; other site
644801000364	ATP binding site [chemical binding]; other site
644801000365	Walker B motif; other site
644801000366	arginine finger; other site
644801000367	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801000368	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
644801000369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801000370	Walker A motif; other site
644801000371	ATP binding site [chemical binding]; other site
644801000372	Walker B motif; other site
644801000373	arginine finger; other site
644801000374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801000375	Walker A motif; other site
644801000376	ATP binding site [chemical binding]; other site
644801000377	Walker B motif; other site
644801000378	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
644801000379	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
644801000380	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
644801000381	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
644801000382	Protein of unknown function (DUF2931); Region: DUF2931; pfam11153
644801000383	Uncharacterized conserved protein [Function unknown]; Region: COG4104
644801000384	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
644801000385	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
644801000386	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
644801000387	Protein of unknown function (DUF877); Region: DUF877; pfam05943
644801000388	Protein of unknown function (DUF770); Region: DUF770; pfam05591
644801000389	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
644801000390	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
644801000391	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
644801000392	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
644801000393	active site
644801000394	phosphate binding residues; other site
644801000395	catalytic residues [active]
644801000396	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
644801000397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000398	dimer interface [polypeptide binding]; other site
644801000399	conserved gate region; other site
644801000400	putative PBP binding loops; other site
644801000401	ABC-ATPase subunit interface; other site
644801000402	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
644801000403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000404	dimer interface [polypeptide binding]; other site
644801000405	conserved gate region; other site
644801000406	putative PBP binding loops; other site
644801000407	ABC-ATPase subunit interface; other site
644801000408	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801000409	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801000410	substrate binding pocket [chemical binding]; other site
644801000411	membrane-bound complex binding site; other site
644801000412	hinge residues; other site
644801000413	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
644801000414	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
644801000415	Walker A/P-loop; other site
644801000416	ATP binding site [chemical binding]; other site
644801000417	Q-loop/lid; other site
644801000418	ABC transporter signature motif; other site
644801000419	Walker B; other site
644801000420	D-loop; other site
644801000421	H-loop/switch region; other site
644801000422	BCCT family transporter; Region: BCCT; pfam02028
644801000423	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
644801000424	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801000425	substrate binding pocket [chemical binding]; other site
644801000426	membrane-bound complex binding site; other site
644801000427	hinge residues; other site
644801000428	Staphylococcal nuclease homologues; Region: SNc; smart00318
644801000429	Catalytic site; other site
644801000430	Staphylococcal nuclease homologue; Region: SNase; pfam00565
644801000431	oxidative damage protection protein; Provisional; Region: PRK05408
644801000432	adenine DNA glycosylase; Provisional; Region: PRK10880
644801000433	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
644801000434	minor groove reading motif; other site
644801000435	helix-hairpin-helix signature motif; other site
644801000436	substrate binding pocket [chemical binding]; other site
644801000437	active site
644801000438	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
644801000439	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
644801000440	DNA binding and oxoG recognition site [nucleotide binding]
644801000441	AsmA family; Region: AsmA; pfam05170
644801000442	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
644801000443	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
644801000444	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
644801000445	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
644801000446	Walker A/P-loop; other site
644801000447	ATP binding site [chemical binding]; other site
644801000448	Q-loop/lid; other site
644801000449	ABC transporter signature motif; other site
644801000450	Walker B; other site
644801000451	D-loop; other site
644801000452	H-loop/switch region; other site
644801000453	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801000454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000455	dimer interface [polypeptide binding]; other site
644801000456	conserved gate region; other site
644801000457	putative PBP binding loops; other site
644801000458	ABC-ATPase subunit interface; other site
644801000459	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801000460	NMT1-like family; Region: NMT1_2; pfam13379
644801000461	Nitrate and nitrite sensing; Region: NIT; pfam08376
644801000462	ANTAR domain; Region: ANTAR; pfam03861
644801000463	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
644801000464	putative active site pocket [active]
644801000465	4-fold oligomerization interface [polypeptide binding]; other site
644801000466	metal binding residues [ion binding]; metal-binding site
644801000467	3-fold/trimer interface [polypeptide binding]; other site
644801000468	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
644801000469	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
644801000470	putative active site [active]
644801000471	oxyanion strand; other site
644801000472	catalytic triad [active]
644801000473	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
644801000474	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
644801000475	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
644801000476	catalytic residues [active]
644801000477	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
644801000478	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
644801000479	substrate binding site [chemical binding]; other site
644801000480	glutamase interaction surface [polypeptide binding]; other site
644801000481	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801000482	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801000483	substrate binding pocket [chemical binding]; other site
644801000484	membrane-bound complex binding site; other site
644801000485	hinge residues; other site
644801000486	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
644801000487	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801000488	substrate binding pocket [chemical binding]; other site
644801000489	membrane-bound complex binding site; other site
644801000490	hinge residues; other site
644801000491	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
644801000492	NodB motif; other site
644801000493	putative active site [active]
644801000494	putative catalytic site [active]
644801000495	Zn binding site [ion binding]; other site
644801000496	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
644801000497	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
644801000498	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
644801000499	protein binding site [polypeptide binding]; other site
644801000500	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
644801000501	Catalytic dyad [active]
644801000502	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
644801000503	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
644801000504	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801000505	phosphoglyceromutase; Provisional; Region: PRK05434
644801000506	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
644801000507	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801000508	active site residue [active]
644801000509	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
644801000510	GSH binding site [chemical binding]; other site
644801000511	catalytic residues [active]
644801000512	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
644801000513	SecA binding site; other site
644801000514	Preprotein binding site; other site
644801000515	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
644801000516	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
644801000517	NAD(P) binding site [chemical binding]; other site
644801000518	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
644801000519	Uncharacterized conserved protein [Function unknown]; Region: COG2947
644801000520	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
644801000521	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
644801000522	TIGR02449 family protein; Region: TIGR02449
644801000523	hypothetical protein; Reviewed; Region: PRK02166
644801000524	proline aminopeptidase P II; Provisional; Region: PRK10879
644801000525	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
644801000526	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
644801000527	active site
644801000528	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
644801000529	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
644801000530	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
644801000531	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
644801000532	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
644801000533	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
644801000534	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
644801000535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000536	dimer interface [polypeptide binding]; other site
644801000537	conserved gate region; other site
644801000538	putative PBP binding loops; other site
644801000539	ABC-ATPase subunit interface; other site
644801000540	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
644801000541	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
644801000542	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
644801000543	lipoyl attachment site [posttranslational modification]; other site
644801000544	glycine dehydrogenase; Provisional; Region: PRK12566
644801000545	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
644801000546	tetramer interface [polypeptide binding]; other site
644801000547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801000548	catalytic residue [active]
644801000549	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
644801000550	tetramer interface [polypeptide binding]; other site
644801000551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801000552	catalytic residue [active]
644801000553	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
644801000554	G1 box; other site
644801000555	GTP/Mg2+ binding site [chemical binding]; other site
644801000556	Switch I region; other site
644801000557	G2 box; other site
644801000558	G3 box; other site
644801000559	Switch II region; other site
644801000560	G4 box; other site
644801000561	G5 box; other site
644801000562	Cytochrome c553 [Energy production and conversion]; Region: COG2863
644801000563	Cytochrome c; Region: Cytochrom_C; cl11414
644801000564	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
644801000565	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
644801000566	catalytic residues [active]
644801000567	hinge region; other site
644801000568	alpha helical domain; other site
644801000569	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
644801000570	putative catalytic site [active]
644801000571	putative metal binding site [ion binding]; other site
644801000572	putative phosphate binding site [ion binding]; other site
644801000573	putative catalytic site [active]
644801000574	putative phosphate binding site [ion binding]; other site
644801000575	putative metal binding site [ion binding]; other site
644801000576	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801000577	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801000578	metal binding site [ion binding]; metal-binding site
644801000579	active site
644801000580	I-site; other site
644801000581	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
644801000582	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
644801000583	amidase catalytic site [active]
644801000584	Zn binding residues [ion binding]; other site
644801000585	substrate binding site [chemical binding]; other site
644801000586	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
644801000587	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
644801000588	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801000589	dimerization interface [polypeptide binding]; other site
644801000590	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
644801000591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801000592	dimer interface [polypeptide binding]; other site
644801000593	phosphorylation site [posttranslational modification]
644801000594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801000595	ATP binding site [chemical binding]; other site
644801000596	Mg2+ binding site [ion binding]; other site
644801000597	G-X-G motif; other site
644801000598	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801000599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801000600	active site
644801000601	phosphorylation site [posttranslational modification]
644801000602	intermolecular recognition site; other site
644801000603	dimerization interface [polypeptide binding]; other site
644801000604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801000605	Walker A motif; other site
644801000606	ATP binding site [chemical binding]; other site
644801000607	Walker B motif; other site
644801000608	arginine finger; other site
644801000609	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801000610	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
644801000611	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
644801000612	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
644801000613	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
644801000614	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
644801000615	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
644801000616	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
644801000617	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
644801000618	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
644801000619	PAS domain; Region: PAS_9; pfam13426
644801000620	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801000621	putative active site [active]
644801000622	heme pocket [chemical binding]; other site
644801000623	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801000624	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801000625	dimer interface [polypeptide binding]; other site
644801000626	putative CheW interface [polypeptide binding]; other site
644801000627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801000628	PAS domain; Region: PAS_9; pfam13426
644801000629	putative active site [active]
644801000630	heme pocket [chemical binding]; other site
644801000631	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801000632	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801000633	dimer interface [polypeptide binding]; other site
644801000634	putative CheW interface [polypeptide binding]; other site
644801000635	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
644801000636	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
644801000637	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801000638	metal binding site [ion binding]; metal-binding site
644801000639	active site
644801000640	I-site; other site
644801000641	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
644801000642	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
644801000643	dimerization interface [polypeptide binding]; other site
644801000644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801000645	dimer interface [polypeptide binding]; other site
644801000646	phosphorylation site [posttranslational modification]
644801000647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801000648	ATP binding site [chemical binding]; other site
644801000649	Mg2+ binding site [ion binding]; other site
644801000650	G-X-G motif; other site
644801000651	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
644801000652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801000653	active site
644801000654	phosphorylation site [posttranslational modification]
644801000655	intermolecular recognition site; other site
644801000656	dimerization interface [polypeptide binding]; other site
644801000657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801000658	DNA binding site [nucleotide binding]
644801000659	outer membrane porin, OprD family; Region: OprD; pfam03573
644801000660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
644801000661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
644801000662	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
644801000663	Putative ammonia monooxygenase; Region: AmoA; pfam05145
644801000664	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
644801000665	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
644801000666	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
644801000667	PhoU domain; Region: PhoU; pfam01895
644801000668	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
644801000669	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
644801000670	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
644801000671	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
644801000672	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
644801000673	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
644801000674	AAA domain; Region: AAA_30; pfam13604
644801000675	Family description; Region: UvrD_C_2; pfam13538
644801000676	Predicted permeases [General function prediction only]; Region: COG0679
644801000677	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801000678	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801000679	metal binding site [ion binding]; metal-binding site
644801000680	active site
644801000681	I-site; other site
644801000682	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
644801000683	PBP superfamily domain; Region: PBP_like_2; cl17296
644801000684	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
644801000685	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
644801000686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000687	dimer interface [polypeptide binding]; other site
644801000688	conserved gate region; other site
644801000689	putative PBP binding loops; other site
644801000690	ABC-ATPase subunit interface; other site
644801000691	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
644801000692	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
644801000693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801000694	dimer interface [polypeptide binding]; other site
644801000695	conserved gate region; other site
644801000696	putative PBP binding loops; other site
644801000697	ABC-ATPase subunit interface; other site
644801000698	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
644801000699	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
644801000700	Walker A/P-loop; other site
644801000701	ATP binding site [chemical binding]; other site
644801000702	Q-loop/lid; other site
644801000703	ABC transporter signature motif; other site
644801000704	Walker B; other site
644801000705	D-loop; other site
644801000706	H-loop/switch region; other site
644801000707	transcriptional regulator PhoU; Provisional; Region: PRK11115
644801000708	PhoU domain; Region: PhoU; pfam01895
644801000709	PhoU domain; Region: PhoU; pfam01895
644801000710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801000711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801000712	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801000713	putative effector binding pocket; other site
644801000714	dimerization interface [polypeptide binding]; other site
644801000715	EamA-like transporter family; Region: EamA; pfam00892
644801000716	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
644801000717	EamA-like transporter family; Region: EamA; pfam00892
644801000718	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
644801000719	G1 box; other site
644801000720	GTP/Mg2+ binding site [chemical binding]; other site
644801000721	G2 box; other site
644801000722	Switch I region; other site
644801000723	G3 box; other site
644801000724	Switch II region; other site
644801000725	G4 box; other site
644801000726	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
644801000727	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
644801000728	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
644801000729	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
644801000730	putative active site [active]
644801000731	catalytic site [active]
644801000732	putative metal binding site [ion binding]; other site
644801000733	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
644801000734	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
644801000735	folate binding site [chemical binding]; other site
644801000736	NADP+ binding site [chemical binding]; other site
644801000737	Uncharacterized conserved protein [Function unknown]; Region: COG1284
644801000738	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
644801000739	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
644801000740	active site
644801000741	metal binding site [ion binding]; metal-binding site
644801000742	homotetramer interface [polypeptide binding]; other site
644801000743	hydroxyglutarate oxidase; Provisional; Region: PRK11728
644801000744	Predicted dehydrogenase [General function prediction only]; Region: COG0579
644801000745	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
644801000746	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
644801000747	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
644801000748	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
644801000749	putative RNA binding site [nucleotide binding]; other site
644801000750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801000751	S-adenosylmethionine binding site [chemical binding]; other site
644801000752	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
644801000753	intracellular protease, PfpI family; Region: PfpI; TIGR01382
644801000754	proposed catalytic triad [active]
644801000755	conserved cys residue [active]
644801000756	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
644801000757	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
644801000758	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
644801000759	DNA binding site [nucleotide binding]
644801000760	catalytic residue [active]
644801000761	H2TH interface [polypeptide binding]; other site
644801000762	putative catalytic residues [active]
644801000763	turnover-facilitating residue; other site
644801000764	intercalation triad [nucleotide binding]; other site
644801000765	8OG recognition residue [nucleotide binding]; other site
644801000766	putative reading head residues; other site
644801000767	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
644801000768	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
644801000769	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
644801000770	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
644801000771	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
644801000772	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
644801000773	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
644801000774	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
644801000775	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
644801000776	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
644801000777	active site
644801000778	(T/H)XGH motif; other site
644801000779	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
644801000780	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801000781	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
644801000782	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
644801000783	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
644801000784	NAD(P) binding site [chemical binding]; other site
644801000785	catalytic residues [active]
644801000786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801000787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801000788	Bacterial transcriptional repressor; Region: TetR; pfam13972
644801000789	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
644801000790	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
644801000791	active site
644801000792	homodimer interface [polypeptide binding]; other site
644801000793	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
644801000794	active site
644801000795	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
644801000796	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
644801000797	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
644801000798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801000799	binding surface
644801000800	TPR motif; other site
644801000801	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
644801000802	hypothetical protein; Provisional; Region: PRK09936
644801000803	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
644801000804	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
644801000805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801000806	S-adenosylmethionine binding site [chemical binding]; other site
644801000807	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
644801000808	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
644801000809	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
644801000810	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
644801000811	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
644801000812	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
644801000813	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
644801000814	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
644801000815	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
644801000816	P loop; other site
644801000817	GTP binding site [chemical binding]; other site
644801000818	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
644801000819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801000820	Walker A/P-loop; other site
644801000821	ATP binding site [chemical binding]; other site
644801000822	Q-loop/lid; other site
644801000823	ABC transporter signature motif; other site
644801000824	Walker B; other site
644801000825	D-loop; other site
644801000826	H-loop/switch region; other site
644801000827	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
644801000828	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
644801000829	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
644801000830	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801000831	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801000832	DNA binding residues [nucleotide binding]
644801000833	CHASE domain; Region: CHASE; pfam03924
644801000834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801000835	PAS fold; Region: PAS_3; pfam08447
644801000836	putative active site [active]
644801000837	heme pocket [chemical binding]; other site
644801000838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801000839	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801000840	dimer interface [polypeptide binding]; other site
644801000841	phosphorylation site [posttranslational modification]
644801000842	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801000843	ATP binding site [chemical binding]; other site
644801000844	Mg2+ binding site [ion binding]; other site
644801000845	G-X-G motif; other site
644801000846	Response regulator receiver domain; Region: Response_reg; pfam00072
644801000847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801000848	active site
644801000849	phosphorylation site [posttranslational modification]
644801000850	intermolecular recognition site; other site
644801000851	dimerization interface [polypeptide binding]; other site
644801000852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801000853	PAS domain; Region: PAS_9; pfam13426
644801000854	putative active site [active]
644801000855	heme pocket [chemical binding]; other site
644801000856	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801000857	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801000858	metal binding site [ion binding]; metal-binding site
644801000859	active site
644801000860	I-site; other site
644801000861	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801000862	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
644801000863	Transglycosylase; Region: Transgly; cl17702
644801000864	Protein of unknown function (DUF423); Region: DUF423; pfam04241
644801000865	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
644801000866	thiS-thiF/thiG interaction site; other site
644801000867	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
644801000868	ThiS interaction site; other site
644801000869	putative active site [active]
644801000870	tetramer interface [polypeptide binding]; other site
644801000871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801000872	S-adenosylmethionine binding site [chemical binding]; other site
644801000873	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
644801000874	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
644801000875	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
644801000876	putative substrate binding site [chemical binding]; other site
644801000877	nucleotide binding site [chemical binding]; other site
644801000878	nucleotide binding site [chemical binding]; other site
644801000879	homodimer interface [polypeptide binding]; other site
644801000880	ornithine carbamoyltransferase; Validated; Region: PRK02102
644801000881	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
644801000882	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
644801000883	arginine deiminase; Provisional; Region: PRK01388
644801000884	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
644801000885	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
644801000886	HemN family oxidoreductase; Provisional; Region: PRK05660
644801000887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801000888	FeS/SAM binding site; other site
644801000889	HemN C-terminal domain; Region: HemN_C; pfam06969
644801000890	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
644801000891	active site
644801000892	dimerization interface [polypeptide binding]; other site
644801000893	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
644801000894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801000895	S-adenosylmethionine binding site [chemical binding]; other site
644801000896	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
644801000897	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
644801000898	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
644801000899	Dynamin family; Region: Dynamin_N; pfam00350
644801000900	G1 box; other site
644801000901	GTP/Mg2+ binding site [chemical binding]; other site
644801000902	G2 box; other site
644801000903	Switch I region; other site
644801000904	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
644801000905	G3 box; other site
644801000906	Switch II region; other site
644801000907	GTP/Mg2+ binding site [chemical binding]; other site
644801000908	G4 box; other site
644801000909	G5 box; other site
644801000910	YGGT family; Region: YGGT; pfam02325
644801000911	YGGT family; Region: YGGT; pfam02325
644801000912	pyrroline-5-carboxylate reductase; Region: PLN02688
644801000913	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
644801000914	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
644801000915	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
644801000916	catalytic residue [active]
644801000917	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
644801000918	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
644801000919	Walker A motif; other site
644801000920	ATP binding site [chemical binding]; other site
644801000921	Walker B motif; other site
644801000922	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
644801000923	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
644801000924	Walker A motif; other site
644801000925	ATP binding site [chemical binding]; other site
644801000926	Walker B motif; other site
644801000927	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
644801000928	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
644801000929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801000930	FeS/SAM binding site; other site
644801000931	TM2 domain; Region: TM2; cl00984
644801000932	TM2 domain; Region: TM2; cl00984
644801000933	dihydroorotase; Validated; Region: pyrC; PRK09357
644801000934	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
644801000935	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
644801000936	active site
644801000937	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
644801000938	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
644801000939	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
644801000940	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801000941	active site
644801000942	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
644801000943	hypothetical protein; Validated; Region: PRK00228
644801000944	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
644801000945	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
644801000946	glutathione synthetase; Provisional; Region: PRK05246
644801000947	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
644801000948	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
644801000949	Response regulator receiver domain; Region: Response_reg; pfam00072
644801000950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801000951	active site
644801000952	phosphorylation site [posttranslational modification]
644801000953	intermolecular recognition site; other site
644801000954	dimerization interface [polypeptide binding]; other site
644801000955	Response regulator receiver domain; Region: Response_reg; pfam00072
644801000956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801000957	active site
644801000958	phosphorylation site [posttranslational modification]
644801000959	intermolecular recognition site; other site
644801000960	dimerization interface [polypeptide binding]; other site
644801000961	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
644801000962	putative CheA interaction surface; other site
644801000963	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
644801000964	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801000965	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801000966	dimer interface [polypeptide binding]; other site
644801000967	putative CheW interface [polypeptide binding]; other site
644801000968	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
644801000969	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
644801000970	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
644801000971	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801000972	putative binding surface; other site
644801000973	active site
644801000974	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801000975	putative binding surface; other site
644801000976	active site
644801000977	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801000978	putative binding surface; other site
644801000979	active site
644801000980	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801000981	putative binding surface; other site
644801000982	active site
644801000983	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801000984	putative binding surface; other site
644801000985	active site
644801000986	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
644801000987	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
644801000988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801000989	ATP binding site [chemical binding]; other site
644801000990	Mg2+ binding site [ion binding]; other site
644801000991	G-X-G motif; other site
644801000992	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
644801000993	Response regulator receiver domain; Region: Response_reg; pfam00072
644801000994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801000995	active site
644801000996	phosphorylation site [posttranslational modification]
644801000997	intermolecular recognition site; other site
644801000998	dimerization interface [polypeptide binding]; other site
644801000999	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
644801001000	CheB methylesterase; Region: CheB_methylest; pfam01339
644801001001	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
644801001002	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
644801001003	RNA methyltransferase, RsmE family; Region: TIGR00046
644801001004	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
644801001005	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801001006	inhibitor-cofactor binding pocket; inhibition site
644801001007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801001008	catalytic residue [active]
644801001009	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
644801001010	hypothetical protein; Provisional; Region: PRK03757
644801001011	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
644801001012	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801001013	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801001014	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
644801001015	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
644801001016	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
644801001017	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
644801001018	ATP binding site [chemical binding]; other site
644801001019	Mg++ binding site [ion binding]; other site
644801001020	motif III; other site
644801001021	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801001022	nucleotide binding region [chemical binding]; other site
644801001023	ATP-binding site [chemical binding]; other site
644801001024	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
644801001025	FAD binding site [chemical binding]; other site
644801001026	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
644801001027	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
644801001028	homotetramer interface [polypeptide binding]; other site
644801001029	ligand binding site [chemical binding]; other site
644801001030	catalytic site [active]
644801001031	NAD binding site [chemical binding]; other site
644801001032	Cytochrome C' Region: Cytochrom_C_2; pfam01322
644801001033	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
644801001034	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
644801001035	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
644801001036	nucleotide binding pocket [chemical binding]; other site
644801001037	K-X-D-G motif; other site
644801001038	catalytic site [active]
644801001039	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
644801001040	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
644801001041	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
644801001042	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
644801001043	FAD binding pocket [chemical binding]; other site
644801001044	FAD binding motif [chemical binding]; other site
644801001045	phosphate binding motif [ion binding]; other site
644801001046	beta-alpha-beta structure motif; other site
644801001047	NAD binding pocket [chemical binding]; other site
644801001048	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
644801001049	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
644801001050	Walker A/P-loop; other site
644801001051	ATP binding site [chemical binding]; other site
644801001052	Q-loop/lid; other site
644801001053	ABC transporter signature motif; other site
644801001054	Walker B; other site
644801001055	D-loop; other site
644801001056	H-loop/switch region; other site
644801001057	ABC-2 type transporter; Region: ABC2_membrane; cl17235
644801001058	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
644801001059	S-adenosylmethionine synthetase; Validated; Region: PRK05250
644801001060	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
644801001061	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
644801001062	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
644801001063	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801001064	putative DNA binding site [nucleotide binding]; other site
644801001065	putative Zn2+ binding site [ion binding]; other site
644801001066	Methyltransferase domain; Region: Methyltransf_31; pfam13847
644801001067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801001068	S-adenosylmethionine binding site [chemical binding]; other site
644801001069	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
644801001070	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
644801001071	substrate binding pocket [chemical binding]; other site
644801001072	active site
644801001073	iron coordination sites [ion binding]; other site
644801001074	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
644801001075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801001076	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
644801001077	dimerization interface [polypeptide binding]; other site
644801001078	substrate binding pocket [chemical binding]; other site
644801001079	transketolase; Reviewed; Region: PRK12753
644801001080	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
644801001081	TPP-binding site [chemical binding]; other site
644801001082	dimer interface [polypeptide binding]; other site
644801001083	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
644801001084	PYR/PP interface [polypeptide binding]; other site
644801001085	dimer interface [polypeptide binding]; other site
644801001086	TPP binding site [chemical binding]; other site
644801001087	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
644801001088	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
644801001089	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
644801001090	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
644801001091	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
644801001092	Phosphoglycerate kinase; Region: PGK; pfam00162
644801001093	substrate binding site [chemical binding]; other site
644801001094	hinge regions; other site
644801001095	ADP binding site [chemical binding]; other site
644801001096	catalytic site [active]
644801001097	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
644801001098	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
644801001099	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
644801001100	intersubunit interface [polypeptide binding]; other site
644801001101	active site
644801001102	zinc binding site [ion binding]; other site
644801001103	Na+ binding site [ion binding]; other site
644801001104	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801001105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001106	active site
644801001107	phosphorylation site [posttranslational modification]
644801001108	intermolecular recognition site; other site
644801001109	dimerization interface [polypeptide binding]; other site
644801001110	Methyltransferase domain; Region: Methyltransf_23; pfam13489
644801001111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801001112	S-adenosylmethionine binding site [chemical binding]; other site
644801001113	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
644801001114	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
644801001115	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
644801001116	heme-binding site [chemical binding]; other site
644801001117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801001118	PAS fold; Region: PAS_3; pfam08447
644801001119	putative active site [active]
644801001120	heme pocket [chemical binding]; other site
644801001121	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801001122	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801001123	metal binding site [ion binding]; metal-binding site
644801001124	active site
644801001125	I-site; other site
644801001126	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801001127	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
644801001128	HI0933-like protein; Region: HI0933_like; pfam03486
644801001129	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801001130	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801001131	substrate binding pocket [chemical binding]; other site
644801001132	membrane-bound complex binding site; other site
644801001133	hinge residues; other site
644801001134	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
644801001135	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
644801001136	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
644801001137	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
644801001138	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
644801001139	ATP binding site [chemical binding]; other site
644801001140	Mg++ binding site [ion binding]; other site
644801001141	motif III; other site
644801001142	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801001143	nucleotide binding region [chemical binding]; other site
644801001144	ATP-binding site [chemical binding]; other site
644801001145	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
644801001146	putative RNA binding site [nucleotide binding]; other site
644801001147	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
644801001148	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
644801001149	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
644801001150	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
644801001151	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
644801001152	Na binding site [ion binding]; other site
644801001153	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
644801001154	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
644801001155	active site
644801001156	catalytic site [active]
644801001157	substrate binding site [chemical binding]; other site
644801001158	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
644801001159	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801001160	ligand binding site [chemical binding]; other site
644801001161	flexible hinge region; other site
644801001162	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
644801001163	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
644801001164	metal binding triad; other site
644801001165	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801001166	dimerization interface [polypeptide binding]; other site
644801001167	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801001168	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801001169	dimer interface [polypeptide binding]; other site
644801001170	putative CheW interface [polypeptide binding]; other site
644801001171	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
644801001172	active site
644801001173	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
644801001174	ACT domain; Region: ACT_6; pfam13740
644801001175	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
644801001176	Predicted permeases [General function prediction only]; Region: RarD; COG2962
644801001177	EamA-like transporter family; Region: EamA; pfam00892
644801001178	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
644801001179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801001180	NAD(P) binding site [chemical binding]; other site
644801001181	active site
644801001182	Trehalase; Region: Trehalase; cl17346
644801001183	Transcriptional regulators [Transcription]; Region: FadR; COG2186
644801001184	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801001185	DNA-binding site [nucleotide binding]; DNA binding site
644801001186	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
644801001187	DctM-like transporters; Region: DctM; pfam06808
644801001188	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
644801001189	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
644801001190	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801001191	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801001192	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
644801001193	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
644801001194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801001195	active site
644801001196	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
644801001197	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
644801001198	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
644801001199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801001200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801001201	dimerization interface [polypeptide binding]; other site
644801001202	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
644801001203	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
644801001204	active site pocket [active]
644801001205	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
644801001206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
644801001207	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
644801001208	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
644801001209	active site
644801001210	tetramer interface [polypeptide binding]; other site
644801001211	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
644801001212	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
644801001213	putative active site [active]
644801001214	catalytic residue [active]
644801001215	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
644801001216	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
644801001217	NAD(P) binding site [chemical binding]; other site
644801001218	catalytic residues [active]
644801001219	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
644801001220	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
644801001221	active site
644801001222	tetramer interface [polypeptide binding]; other site
644801001223	galactarate dehydratase; Region: galactar-dH20; TIGR03248
644801001224	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
644801001225	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
644801001226	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
644801001227	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
644801001228	putative ligand binding site [chemical binding]; other site
644801001229	NAD binding site [chemical binding]; other site
644801001230	catalytic site [active]
644801001231	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
644801001232	active site
644801001233	catalytic residues [active]
644801001234	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
644801001235	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801001236	N-terminal plug; other site
644801001237	ligand-binding site [chemical binding]; other site
644801001238	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
644801001239	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
644801001240	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
644801001241	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
644801001242	outer membrane porin, OprD family; Region: OprD; pfam03573
644801001243	Water Stress and Hypersensitive response; Region: WHy; smart00769
644801001244	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
644801001245	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
644801001246	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
644801001247	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
644801001248	dimer interface [polypeptide binding]; other site
644801001249	active site residues [active]
644801001250	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
644801001251	short chain dehydrogenase; Provisional; Region: PRK07109
644801001252	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
644801001253	putative NAD(P) binding site [chemical binding]; other site
644801001254	active site
644801001255	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
644801001256	CHASE3 domain; Region: CHASE3; pfam05227
644801001257	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
644801001258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801001259	dimer interface [polypeptide binding]; other site
644801001260	phosphorylation site [posttranslational modification]
644801001261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001262	ATP binding site [chemical binding]; other site
644801001263	Mg2+ binding site [ion binding]; other site
644801001264	G-X-G motif; other site
644801001265	Response regulator receiver domain; Region: Response_reg; pfam00072
644801001266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001267	active site
644801001268	phosphorylation site [posttranslational modification]
644801001269	intermolecular recognition site; other site
644801001270	dimerization interface [polypeptide binding]; other site
644801001271	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801001272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001273	active site
644801001274	phosphorylation site [posttranslational modification]
644801001275	intermolecular recognition site; other site
644801001276	Response regulator receiver domain; Region: Response_reg; pfam00072
644801001277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001278	active site
644801001279	phosphorylation site [posttranslational modification]
644801001280	intermolecular recognition site; other site
644801001281	dimerization interface [polypeptide binding]; other site
644801001282	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
644801001283	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
644801001284	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
644801001285	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
644801001286	CheB methylesterase; Region: CheB_methylest; pfam01339
644801001287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001288	active site
644801001289	phosphorylation site [posttranslational modification]
644801001290	intermolecular recognition site; other site
644801001291	dimerization interface [polypeptide binding]; other site
644801001292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801001293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801001294	dimer interface [polypeptide binding]; other site
644801001295	phosphorylation site [posttranslational modification]
644801001296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001297	ATP binding site [chemical binding]; other site
644801001298	Mg2+ binding site [ion binding]; other site
644801001299	G-X-G motif; other site
644801001300	Uncharacterized conserved protein [Function unknown]; Region: COG0397
644801001301	hypothetical protein; Validated; Region: PRK00029
644801001302	hypothetical protein; Provisional; Region: PRK11281
644801001303	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
644801001304	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801001305	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
644801001306	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
644801001307	TrkA-C domain; Region: TrkA_C; pfam02080
644801001308	Transporter associated domain; Region: CorC_HlyC; smart01091
644801001309	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
644801001310	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
644801001311	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801001312	active site
644801001313	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
644801001314	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
644801001315	substrate binding pocket [chemical binding]; other site
644801001316	substrate-Mg2+ binding site; other site
644801001317	aspartate-rich region 1; other site
644801001318	aspartate-rich region 2; other site
644801001319	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
644801001320	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
644801001321	homotetramer interface [polypeptide binding]; other site
644801001322	FMN binding site [chemical binding]; other site
644801001323	homodimer contacts [polypeptide binding]; other site
644801001324	putative active site [active]
644801001325	putative substrate binding site [chemical binding]; other site
644801001326	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
644801001327	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
644801001328	active site
644801001329	TDP-binding site; other site
644801001330	acceptor substrate-binding pocket; other site
644801001331	homodimer interface [polypeptide binding]; other site
644801001332	lycopene cyclase; Region: lycopene_cycl; TIGR01789
644801001333	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
644801001334	phytoene desaturase; Region: crtI_fam; TIGR02734
644801001335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801001336	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
644801001337	active site lid residues [active]
644801001338	substrate binding pocket [chemical binding]; other site
644801001339	catalytic residues [active]
644801001340	substrate-Mg2+ binding site; other site
644801001341	aspartate-rich region 1; other site
644801001342	aspartate-rich region 2; other site
644801001343	beta-carotene hydroxylase; Region: PLN02601
644801001344	Nitronate monooxygenase; Region: NMO; pfam03060
644801001345	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
644801001346	FMN binding site [chemical binding]; other site
644801001347	substrate binding site [chemical binding]; other site
644801001348	putative catalytic residue [active]
644801001349	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
644801001350	serine/threonine protein kinase; Provisional; Region: PRK11768
644801001351	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
644801001352	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
644801001353	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801001354	active site
644801001355	biotin synthase; Provisional; Region: PRK15108
644801001356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801001357	FeS/SAM binding site; other site
644801001358	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
644801001359	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
644801001360	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
644801001361	substrate-cofactor binding pocket; other site
644801001362	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801001363	catalytic residue [active]
644801001364	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
644801001365	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
644801001366	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801001367	S-adenosylmethionine binding site [chemical binding]; other site
644801001368	AAA domain; Region: AAA_26; pfam13500
644801001369	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
644801001370	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
644801001371	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
644801001372	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801001373	active site
644801001374	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
644801001375	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801001376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801001377	metal binding site [ion binding]; metal-binding site
644801001378	active site
644801001379	I-site; other site
644801001380	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
644801001381	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
644801001382	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801001383	active site
644801001384	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
644801001385	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801001386	active site
644801001387	DNA binding site [nucleotide binding]
644801001388	Int/Topo IB signature motif; other site
644801001389	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801001390	active site
644801001391	DNA binding site [nucleotide binding]
644801001392	Int/Topo IB signature motif; other site
644801001393	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801001394	active site
644801001395	catalytic residues [active]
644801001396	DNA binding site [nucleotide binding]
644801001397	Int/Topo IB signature motif; other site
644801001398	putative transposase OrfB; Reviewed; Region: PHA02517
644801001399	HTH-like domain; Region: HTH_21; pfam13276
644801001400	Integrase core domain; Region: rve; pfam00665
644801001401	Integrase core domain; Region: rve_2; pfam13333
644801001402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
644801001403	Transposase; Region: HTH_Tnp_1; pfam01527
644801001404	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
644801001405	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
644801001406	Walker A/P-loop; other site
644801001407	ATP binding site [chemical binding]; other site
644801001408	Q-loop/lid; other site
644801001409	ABC transporter signature motif; other site
644801001410	Walker B; other site
644801001411	D-loop; other site
644801001412	H-loop/switch region; other site
644801001413	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
644801001414	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
644801001415	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
644801001416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801001417	dimer interface [polypeptide binding]; other site
644801001418	conserved gate region; other site
644801001419	putative PBP binding loops; other site
644801001420	ABC-ATPase subunit interface; other site
644801001421	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
644801001422	Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157
644801001423	homodimer interface [polypeptide binding]; other site
644801001424	ligand binding site [chemical binding]; other site
644801001425	NAD binding site [chemical binding]; other site
644801001426	catalytic site [active]
644801001427	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801001428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801001429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801001430	dimerization interface [polypeptide binding]; other site
644801001431	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
644801001432	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
644801001433	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801001434	non-specific DNA binding site [nucleotide binding]; other site
644801001435	salt bridge; other site
644801001436	sequence-specific DNA binding site [nucleotide binding]; other site
644801001437	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
644801001438	NACHT domain; Region: NACHT; pfam05729
644801001439	Walker A motif; other site
644801001440	ATP binding site [chemical binding]; other site
644801001441	Walker B motif; other site
644801001442	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
644801001443	active site
644801001444	catalytic triad [active]
644801001445	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
644801001446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801001447	Walker A motif; other site
644801001448	ATP binding site [chemical binding]; other site
644801001449	Walker B motif; other site
644801001450	arginine finger; other site
644801001451	methionine sulfoxide reductase A; Provisional; Region: PRK14054
644801001452	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
644801001453	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801001454	putative active site [active]
644801001455	heme pocket [chemical binding]; other site
644801001456	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
644801001457	GAF domain; Region: GAF; pfam01590
644801001458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801001459	PAS domain; Region: PAS_9; pfam13426
644801001460	putative active site [active]
644801001461	heme pocket [chemical binding]; other site
644801001462	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801001463	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801001464	metal binding site [ion binding]; metal-binding site
644801001465	active site
644801001466	I-site; other site
644801001467	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801001468	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
644801001469	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801001470	E3 interaction surface; other site
644801001471	lipoyl attachment site [posttranslational modification]; other site
644801001472	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801001473	E3 interaction surface; other site
644801001474	lipoyl attachment site [posttranslational modification]; other site
644801001475	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801001476	E3 interaction surface; other site
644801001477	lipoyl attachment site [posttranslational modification]; other site
644801001478	e3 binding domain; Region: E3_binding; pfam02817
644801001479	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
644801001480	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
644801001481	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
644801001482	dimer interface [polypeptide binding]; other site
644801001483	TPP-binding site [chemical binding]; other site
644801001484	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
644801001485	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
644801001486	metal binding triad; other site
644801001487	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
644801001488	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
644801001489	metal binding triad; other site
644801001490	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
644801001491	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
644801001492	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
644801001493	homodimer interface [polypeptide binding]; other site
644801001494	substrate-cofactor binding pocket; other site
644801001495	catalytic residue [active]
644801001496	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
644801001497	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
644801001498	putative active site [active]
644801001499	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
644801001500	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
644801001501	putative active site [active]
644801001502	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801001503	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
644801001504	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
644801001505	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
644801001506	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
644801001507	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
644801001508	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
644801001509	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
644801001510	active site
644801001511	ATP binding site [chemical binding]; other site
644801001512	serine/threonine protein kinase; Provisional; Region: PRK14879
644801001513	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
644801001514	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
644801001515	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
644801001516	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
644801001517	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801001518	putative ADP-binding pocket [chemical binding]; other site
644801001519	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
644801001520	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
644801001521	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
644801001522	trimer interface [polypeptide binding]; other site
644801001523	active site
644801001524	substrate binding site [chemical binding]; other site
644801001525	CoA binding site [chemical binding]; other site
644801001526	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
644801001527	active site
644801001528	substrate binding site [chemical binding]; other site
644801001529	ATP binding site [chemical binding]; other site
644801001530	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
644801001531	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
644801001532	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
644801001533	Walker A/P-loop; other site
644801001534	ATP binding site [chemical binding]; other site
644801001535	Q-loop/lid; other site
644801001536	ABC transporter signature motif; other site
644801001537	Walker B; other site
644801001538	D-loop; other site
644801001539	H-loop/switch region; other site
644801001540	Mig-14; Region: Mig-14; pfam07395
644801001541	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
644801001542	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
644801001543	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
644801001544	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
644801001545	putative ribose interaction site [chemical binding]; other site
644801001546	putative ADP binding site [chemical binding]; other site
644801001547	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
644801001548	active site
644801001549	nucleotide binding site [chemical binding]; other site
644801001550	HIGH motif; other site
644801001551	KMSKS motif; other site
644801001552	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
644801001553	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
644801001554	active site
644801001555	catalytic tetrad [active]
644801001556	FAD dependent oxidoreductase; Region: DAO; pfam01266
644801001557	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801001558	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
644801001559	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
644801001560	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
644801001561	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
644801001562	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
644801001563	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
644801001564	ThiC-associated domain; Region: ThiC-associated; pfam13667
644801001565	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
644801001566	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
644801001567	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
644801001568	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
644801001569	dimer interface [polypeptide binding]; other site
644801001570	ADP-ribose binding site [chemical binding]; other site
644801001571	active site
644801001572	nudix motif; other site
644801001573	metal binding site [ion binding]; metal-binding site
644801001574	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
644801001575	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
644801001576	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
644801001577	active site
644801001578	metal binding site [ion binding]; metal-binding site
644801001579	hexamer interface [polypeptide binding]; other site
644801001580	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
644801001581	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801001582	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
644801001583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001584	ATP binding site [chemical binding]; other site
644801001585	Mg2+ binding site [ion binding]; other site
644801001586	G-X-G motif; other site
644801001587	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
644801001588	anchoring element; other site
644801001589	dimer interface [polypeptide binding]; other site
644801001590	ATP binding site [chemical binding]; other site
644801001591	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
644801001592	active site
644801001593	metal binding site [ion binding]; metal-binding site
644801001594	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
644801001595	SdiA-regulated; Region: SdiA-regulated; cd09971
644801001596	putative active site [active]
644801001597	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
644801001598	catalytic motif [active]
644801001599	Catalytic residue [active]
644801001600	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
644801001601	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
644801001602	CAP-like domain; other site
644801001603	active site
644801001604	primary dimer interface [polypeptide binding]; other site
644801001605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
644801001606	Protein of unknown function (DUF330); Region: DUF330; pfam03886
644801001607	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
644801001608	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
644801001609	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
644801001610	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
644801001611	phosphoserine phosphatase SerB; Region: serB; TIGR00338
644801001612	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801001613	motif II; other site
644801001614	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
644801001615	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
644801001616	tetramer interface [polypeptide binding]; other site
644801001617	catalytic Zn binding site [ion binding]; other site
644801001618	NADP binding site [chemical binding]; other site
644801001619	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801001620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001621	active site
644801001622	phosphorylation site [posttranslational modification]
644801001623	intermolecular recognition site; other site
644801001624	dimerization interface [polypeptide binding]; other site
644801001625	PAS domain S-box; Region: sensory_box; TIGR00229
644801001626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801001627	putative active site [active]
644801001628	heme pocket [chemical binding]; other site
644801001629	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801001630	metal binding site [ion binding]; metal-binding site
644801001631	active site
644801001632	I-site; other site
644801001633	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801001634	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
644801001635	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
644801001636	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
644801001637	active site residue [active]
644801001638	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
644801001639	active site residue [active]
644801001640	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
644801001641	flagellar motor protein MotA; Validated; Region: PRK09110
644801001642	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
644801001643	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
644801001644	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801001645	ligand binding site [chemical binding]; other site
644801001646	GTPase RsgA; Reviewed; Region: PRK12288
644801001647	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
644801001648	RNA binding site [nucleotide binding]; other site
644801001649	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
644801001650	GTPase/Zn-binding domain interface [polypeptide binding]; other site
644801001651	GTP/Mg2+ binding site [chemical binding]; other site
644801001652	G4 box; other site
644801001653	G5 box; other site
644801001654	G1 box; other site
644801001655	Switch I region; other site
644801001656	G2 box; other site
644801001657	G3 box; other site
644801001658	Switch II region; other site
644801001659	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
644801001660	catalytic site [active]
644801001661	putative active site [active]
644801001662	putative substrate binding site [chemical binding]; other site
644801001663	dimer interface [polypeptide binding]; other site
644801001664	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
644801001665	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
644801001666	NAD binding site [chemical binding]; other site
644801001667	active site
644801001668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
644801001669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
644801001670	MORN repeat; Region: MORN; cl14787
644801001671	Peptidase C13 family; Region: Peptidase_C13; cl02159
644801001672	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
644801001673	putative active site [active]
644801001674	putative catalytic site [active]
644801001675	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
644801001676	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
644801001677	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
644801001678	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
644801001679	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
644801001680	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
644801001681	active site
644801001682	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
644801001683	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
644801001684	putative catalytic cysteine [active]
644801001685	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
644801001686	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
644801001687	active site
644801001688	(T/H)XGH motif; other site
644801001689	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
644801001690	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
644801001691	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
644801001692	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
644801001693	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
644801001694	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
644801001695	Transglycosylase SLT domain; Region: SLT_2; pfam13406
644801001696	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801001697	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801001698	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
644801001699	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
644801001700	Sporulation related domain; Region: SPOR; pfam05036
644801001701	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
644801001702	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
644801001703	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
644801001704	Protein of unknown function (DUF493); Region: DUF493; cl01102
644801001705	lipoate-protein ligase B; Provisional; Region: PRK14342
644801001706	lipoyl synthase; Provisional; Region: PRK05481
644801001707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801001708	FeS/SAM binding site; other site
644801001709	Transglycosylase SLT domain; Region: SLT_2; pfam13406
644801001710	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801001711	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801001712	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
644801001713	Domain of unknown function; Region: DUF331; cl01149
644801001714	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
644801001715	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
644801001716	Lipopolysaccharide-assembly; Region: LptE; cl01125
644801001717	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
644801001718	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
644801001719	HIGH motif; other site
644801001720	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
644801001721	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
644801001722	active site
644801001723	KMSKS motif; other site
644801001724	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
644801001725	tRNA binding surface [nucleotide binding]; other site
644801001726	Uncharacterized conserved protein [Function unknown]; Region: COG1434
644801001727	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
644801001728	putative active site [active]
644801001729	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
644801001730	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
644801001731	putative active site [active]
644801001732	catalytic triad [active]
644801001733	putative dimer interface [polypeptide binding]; other site
644801001734	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
644801001735	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
644801001736	Transporter associated domain; Region: CorC_HlyC; smart01091
644801001737	metal-binding heat shock protein; Provisional; Region: PRK00016
644801001738	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
644801001739	PhoH-like protein; Region: PhoH; pfam02562
644801001740	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
644801001741	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
644801001742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801001743	FeS/SAM binding site; other site
644801001744	TRAM domain; Region: TRAM; pfam01938
644801001745	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
644801001746	Sel1-like repeats; Region: SEL1; smart00671
644801001747	Sel1-like repeats; Region: SEL1; smart00671
644801001748	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
644801001749	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801001750	inhibitor-cofactor binding pocket; inhibition site
644801001751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801001752	catalytic residue [active]
644801001753	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
644801001754	thiamine phosphate binding site [chemical binding]; other site
644801001755	active site
644801001756	pyrophosphate binding site [ion binding]; other site
644801001757	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
644801001758	dimer interface [polypeptide binding]; other site
644801001759	substrate binding site [chemical binding]; other site
644801001760	ATP binding site [chemical binding]; other site
644801001761	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
644801001762	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
644801001763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801001764	dimer interface [polypeptide binding]; other site
644801001765	phosphorylation site [posttranslational modification]
644801001766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001767	ATP binding site [chemical binding]; other site
644801001768	Mg2+ binding site [ion binding]; other site
644801001769	G-X-G motif; other site
644801001770	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801001771	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801001772	active site
644801001773	Ion transport protein; Region: Ion_trans; pfam00520
644801001774	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
644801001775	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
644801001776	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
644801001777	AMP nucleosidase; Provisional; Region: PRK08292
644801001778	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
644801001779	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
644801001780	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
644801001781	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
644801001782	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
644801001783	G1 box; other site
644801001784	GTP/Mg2+ binding site [chemical binding]; other site
644801001785	G2 box; other site
644801001786	Switch I region; other site
644801001787	G3 box; other site
644801001788	Switch II region; other site
644801001789	G4 box; other site
644801001790	G5 box; other site
644801001791	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
644801001792	UreF; Region: UreF; pfam01730
644801001793	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
644801001794	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
644801001795	dimer interface [polypeptide binding]; other site
644801001796	catalytic residues [active]
644801001797	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
644801001798	EamA-like transporter family; Region: EamA; pfam00892
644801001799	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
644801001800	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
644801001801	tetramer interface [polypeptide binding]; other site
644801001802	active site
644801001803	Mg2+/Mn2+ binding site [ion binding]; other site
644801001804	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
644801001805	hypothetical protein; Provisional; Region: PRK11019
644801001806	GAF domain; Region: GAF; pfam01590
644801001807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801001808	dimer interface [polypeptide binding]; other site
644801001809	phosphorylation site [posttranslational modification]
644801001810	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
644801001811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001812	ATP binding site [chemical binding]; other site
644801001813	Mg2+ binding site [ion binding]; other site
644801001814	G-X-G motif; other site
644801001815	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
644801001816	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
644801001817	Na binding site [ion binding]; other site
644801001818	putative substrate binding site [chemical binding]; other site
644801001819	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801001820	urease subunit alpha; Reviewed; Region: ureC; PRK13207
644801001821	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
644801001822	subunit interactions [polypeptide binding]; other site
644801001823	active site
644801001824	flap region; other site
644801001825	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
644801001826	gamma-beta subunit interface [polypeptide binding]; other site
644801001827	alpha-beta subunit interface [polypeptide binding]; other site
644801001828	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
644801001829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801001830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
644801001831	Coenzyme A binding pocket [chemical binding]; other site
644801001832	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
644801001833	alpha-gamma subunit interface [polypeptide binding]; other site
644801001834	beta-gamma subunit interface [polypeptide binding]; other site
644801001835	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
644801001836	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
644801001837	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
644801001838	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801001839	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
644801001840	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801001841	motif II; other site
644801001842	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
644801001843	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
644801001844	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
644801001845	Walker A/P-loop; other site
644801001846	ATP binding site [chemical binding]; other site
644801001847	Q-loop/lid; other site
644801001848	ABC transporter signature motif; other site
644801001849	Walker B; other site
644801001850	D-loop; other site
644801001851	H-loop/switch region; other site
644801001852	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
644801001853	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
644801001854	Walker A/P-loop; other site
644801001855	ATP binding site [chemical binding]; other site
644801001856	Q-loop/lid; other site
644801001857	ABC transporter signature motif; other site
644801001858	Walker B; other site
644801001859	D-loop; other site
644801001860	H-loop/switch region; other site
644801001861	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
644801001862	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
644801001863	TM-ABC transporter signature motif; other site
644801001864	HEAT repeats; Region: HEAT_2; pfam13646
644801001865	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
644801001866	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801001867	TM-ABC transporter signature motif; other site
644801001868	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
644801001869	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
644801001870	putative ligand binding site [chemical binding]; other site
644801001871	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
644801001872	pseudouridine synthase; Region: TIGR00093
644801001873	active site
644801001874	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
644801001875	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
644801001876	heme-binding site [chemical binding]; other site
644801001877	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801001878	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801001879	putative DNA binding site [nucleotide binding]; other site
644801001880	putative Zn2+ binding site [ion binding]; other site
644801001881	AsnC family; Region: AsnC_trans_reg; pfam01037
644801001882	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
644801001883	Cation efflux family; Region: Cation_efflux; cl00316
644801001884	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801001885	ATP binding site [chemical binding]; other site
644801001886	putative Mg++ binding site [ion binding]; other site
644801001887	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
644801001888	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
644801001889	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801001890	non-specific DNA binding site [nucleotide binding]; other site
644801001891	salt bridge; other site
644801001892	sequence-specific DNA binding site [nucleotide binding]; other site
644801001893	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
644801001894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001895	active site
644801001896	phosphorylation site [posttranslational modification]
644801001897	intermolecular recognition site; other site
644801001898	dimerization interface [polypeptide binding]; other site
644801001899	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801001900	DNA binding site [nucleotide binding]
644801001901	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
644801001902	Multicopper oxidase; Region: Cu-oxidase; pfam00394
644801001903	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
644801001904	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
644801001905	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801001906	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
644801001907	dimerization interface [polypeptide binding]; other site
644801001908	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801001909	NAD(P) binding site [chemical binding]; other site
644801001910	active site
644801001911	Domain of unknown function (DUF305); Region: DUF305; cl17794
644801001912	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
644801001913	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
644801001914	HAMP domain; Region: HAMP; pfam00672
644801001915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801001916	dimer interface [polypeptide binding]; other site
644801001917	phosphorylation site [posttranslational modification]
644801001918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001919	ATP binding site [chemical binding]; other site
644801001920	Mg2+ binding site [ion binding]; other site
644801001921	G-X-G motif; other site
644801001922	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
644801001923	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
644801001924	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
644801001925	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801001926	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
644801001927	Outer membrane efflux protein; Region: OEP; pfam02321
644801001928	YHS domain; Region: YHS; pfam04945
644801001929	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
644801001930	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801001931	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801001932	motif II; other site
644801001933	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
644801001934	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801001935	motif II; other site
644801001936	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801001937	metal-binding site [ion binding]
644801001938	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
644801001939	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
644801001940	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
644801001941	DNA binding residues [nucleotide binding]
644801001942	dimer interface [polypeptide binding]; other site
644801001943	putative metal binding site [ion binding]; other site
644801001944	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
644801001945	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801001946	dimerization interface [polypeptide binding]; other site
644801001947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801001948	dimer interface [polypeptide binding]; other site
644801001949	phosphorylation site [posttranslational modification]
644801001950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801001951	ATP binding site [chemical binding]; other site
644801001952	Mg2+ binding site [ion binding]; other site
644801001953	G-X-G motif; other site
644801001954	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
644801001955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801001956	active site
644801001957	phosphorylation site [posttranslational modification]
644801001958	intermolecular recognition site; other site
644801001959	dimerization interface [polypeptide binding]; other site
644801001960	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801001961	DNA binding site [nucleotide binding]
644801001962	outer membrane porin, OprD family; Region: OprD; pfam03573
644801001963	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
644801001964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801001965	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
644801001966	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801001967	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
644801001968	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
644801001969	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
644801001970	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
644801001971	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
644801001972	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
644801001973	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
644801001974	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
644801001975	P-loop containing region of AAA domain; Region: AAA_29; cl17516
644801001976	AAA domain; Region: AAA_21; pfam13304
644801001977	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
644801001978	putative active site [active]
644801001979	putative metal-binding site [ion binding]; other site
644801001980	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
644801001981	Part of AAA domain; Region: AAA_19; pfam13245
644801001982	Family description; Region: UvrD_C_2; pfam13538
644801001983	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
644801001984	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801001985	ATP binding site [chemical binding]; other site
644801001986	putative Mg++ binding site [ion binding]; other site
644801001987	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801001988	nucleotide binding region [chemical binding]; other site
644801001989	ATP-binding site [chemical binding]; other site
644801001990	Helicase associated domain (HA2); Region: HA2; pfam04408
644801001991	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
644801001992	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801001993	active site
644801001994	catalytic residues [active]
644801001995	DNA binding site [nucleotide binding]
644801001996	Int/Topo IB signature motif; other site
644801001997	BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; Region: BAH; cl02608
644801001998	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801001999	nucleotide binding region [chemical binding]; other site
644801002000	ATP-binding site [chemical binding]; other site
644801002001	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
644801002002	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
644801002003	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801002004	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801002005	substrate binding pocket [chemical binding]; other site
644801002006	membrane-bound complex binding site; other site
644801002007	hinge residues; other site
644801002008	short chain dehydrogenase; Provisional; Region: PRK06181
644801002009	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801002010	NAD(P) binding site [chemical binding]; other site
644801002011	active site
644801002012	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801002013	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
644801002014	Uncharacterized conserved protein [Function unknown]; Region: COG1432
644801002015	LabA_like proteins; Region: LabA; cd10911
644801002016	putative metal binding site [ion binding]; other site
644801002017	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
644801002018	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
644801002019	TPP-binding site; other site
644801002020	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
644801002021	PYR/PP interface [polypeptide binding]; other site
644801002022	dimer interface [polypeptide binding]; other site
644801002023	TPP binding site [chemical binding]; other site
644801002024	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
644801002025	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
644801002026	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
644801002027	substrate binding pocket [chemical binding]; other site
644801002028	chain length determination region; other site
644801002029	substrate-Mg2+ binding site; other site
644801002030	catalytic residues [active]
644801002031	aspartate-rich region 1; other site
644801002032	active site lid residues [active]
644801002033	aspartate-rich region 2; other site
644801002034	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
644801002035	siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950
644801002036	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
644801002037	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
644801002038	IucA / IucC family; Region: IucA_IucC; pfam04183
644801002039	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
644801002040	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
644801002041	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
644801002042	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
644801002043	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
644801002044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801002045	catalytic residue [active]
644801002046	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
644801002047	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801002048	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801002049	DNA binding residues [nucleotide binding]
644801002050	PAS domain S-box; Region: sensory_box; TIGR00229
644801002051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801002052	putative active site [active]
644801002053	heme pocket [chemical binding]; other site
644801002054	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801002055	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801002056	active site
644801002057	I-site; other site
644801002058	metal binding site [ion binding]; metal-binding site
644801002059	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801002060	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801002061	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
644801002062	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
644801002063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002064	active site
644801002065	phosphorylation site [posttranslational modification]
644801002066	intermolecular recognition site; other site
644801002067	CheB methylesterase; Region: CheB_methylest; pfam01339
644801002068	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
644801002069	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
644801002070	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
644801002071	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
644801002072	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
644801002073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801002074	dimerization interface [polypeptide binding]; other site
644801002075	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801002076	dimer interface [polypeptide binding]; other site
644801002077	putative CheW interface [polypeptide binding]; other site
644801002078	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801002079	putative binding surface; other site
644801002080	active site
644801002081	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
644801002082	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
644801002083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801002084	ATP binding site [chemical binding]; other site
644801002085	Mg2+ binding site [ion binding]; other site
644801002086	G-X-G motif; other site
644801002087	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
644801002088	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
644801002089	anti sigma factor interaction site; other site
644801002090	regulatory phosphorylation site [posttranslational modification]; other site
644801002091	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801002092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002093	active site
644801002094	phosphorylation site [posttranslational modification]
644801002095	intermolecular recognition site; other site
644801002096	dimerization interface [polypeptide binding]; other site
644801002097	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801002098	dimer interface [polypeptide binding]; other site
644801002099	putative CheW interface [polypeptide binding]; other site
644801002100	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
644801002101	PAS fold; Region: PAS; pfam00989
644801002102	PAS domain; Region: PAS_8; pfam13188
644801002103	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
644801002104	Histidine kinase; Region: HisKA_3; pfam07730
644801002105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801002106	ATP binding site [chemical binding]; other site
644801002107	G-X-G motif; other site
644801002108	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801002109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002110	active site
644801002111	phosphorylation site [posttranslational modification]
644801002112	intermolecular recognition site; other site
644801002113	dimerization interface [polypeptide binding]; other site
644801002114	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801002115	DNA binding residues [nucleotide binding]
644801002116	dimerization interface [polypeptide binding]; other site
644801002117	PAS fold; Region: PAS_4; pfam08448
644801002118	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801002119	PAS domain; Region: PAS_9; pfam13426
644801002120	putative active site [active]
644801002121	heme pocket [chemical binding]; other site
644801002122	PAS fold; Region: PAS_4; pfam08448
644801002123	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801002124	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801002125	metal binding site [ion binding]; metal-binding site
644801002126	active site
644801002127	I-site; other site
644801002128	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
644801002129	dimer interface [polypeptide binding]; other site
644801002130	substrate binding site [chemical binding]; other site
644801002131	metal binding sites [ion binding]; metal-binding site
644801002132	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
644801002133	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
644801002134	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
644801002135	putative active site [active]
644801002136	putative metal binding site [ion binding]; other site
644801002137	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
644801002138	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
644801002139	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
644801002140	ethanolamine permease; Region: 2A0305; TIGR00908
644801002141	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
644801002142	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
644801002143	NAD(P) binding site [chemical binding]; other site
644801002144	catalytic residues [active]
644801002145	putative alcohol dehydrogenase; Provisional; Region: PRK09860
644801002146	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
644801002147	dimer interface [polypeptide binding]; other site
644801002148	active site
644801002149	metal binding site [ion binding]; metal-binding site
644801002150	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
644801002151	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
644801002152	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
644801002153	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
644801002154	aromatic acid decarboxylase; Validated; Region: PRK05920
644801002155	Flavoprotein; Region: Flavoprotein; pfam02441
644801002156	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
644801002157	FtsH Extracellular; Region: FtsH_ext; pfam06480
644801002158	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
644801002159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002160	Walker A motif; other site
644801002161	ATP binding site [chemical binding]; other site
644801002162	Walker B motif; other site
644801002163	arginine finger; other site
644801002164	Peptidase family M41; Region: Peptidase_M41; pfam01434
644801002165	epoxyqueuosine reductase; Region: TIGR00276
644801002166	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
644801002167	putative carbohydrate kinase; Provisional; Region: PRK10565
644801002168	Uncharacterized conserved protein [Function unknown]; Region: COG0062
644801002169	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
644801002170	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
644801002171	AMIN domain; Region: AMIN; pfam11741
644801002172	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
644801002173	active site
644801002174	metal binding site [ion binding]; metal-binding site
644801002175	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801002176	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
644801002177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801002178	ATP binding site [chemical binding]; other site
644801002179	Mg2+ binding site [ion binding]; other site
644801002180	G-X-G motif; other site
644801002181	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
644801002182	ATP binding site [chemical binding]; other site
644801002183	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
644801002184	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
644801002185	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
644801002186	bacterial Hfq-like; Region: Hfq; cd01716
644801002187	hexamer interface [polypeptide binding]; other site
644801002188	Sm1 motif; other site
644801002189	RNA binding site [nucleotide binding]; other site
644801002190	Sm2 motif; other site
644801002191	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
644801002192	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
644801002193	HflX GTPase family; Region: HflX; cd01878
644801002194	G1 box; other site
644801002195	GTP/Mg2+ binding site [chemical binding]; other site
644801002196	Switch I region; other site
644801002197	G2 box; other site
644801002198	G3 box; other site
644801002199	Switch II region; other site
644801002200	G4 box; other site
644801002201	G5 box; other site
644801002202	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
644801002203	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
644801002204	HflK protein; Region: hflK; TIGR01933
644801002205	FtsH protease regulator HflC; Provisional; Region: PRK11029
644801002206	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
644801002207	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
644801002208	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
644801002209	dimer interface [polypeptide binding]; other site
644801002210	motif 1; other site
644801002211	active site
644801002212	motif 2; other site
644801002213	motif 3; other site
644801002214	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
644801002215	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
644801002216	GDP-binding site [chemical binding]; other site
644801002217	ACT binding site; other site
644801002218	IMP binding site; other site
644801002219	ribonuclease R; Region: RNase_R; TIGR02063
644801002220	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
644801002221	RNB domain; Region: RNB; pfam00773
644801002222	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
644801002223	RNA binding site [nucleotide binding]; other site
644801002224	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
644801002225	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
644801002226	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
644801002227	PAS fold; Region: PAS_4; pfam08448
644801002228	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801002229	putative active site [active]
644801002230	heme pocket [chemical binding]; other site
644801002231	PAS domain; Region: PAS_9; pfam13426
644801002232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801002233	dimer interface [polypeptide binding]; other site
644801002234	phosphorylation site [posttranslational modification]
644801002235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801002236	ATP binding site [chemical binding]; other site
644801002237	Mg2+ binding site [ion binding]; other site
644801002238	G-X-G motif; other site
644801002239	Response regulator receiver domain; Region: Response_reg; pfam00072
644801002240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002241	active site
644801002242	phosphorylation site [posttranslational modification]
644801002243	intermolecular recognition site; other site
644801002244	dimerization interface [polypeptide binding]; other site
644801002245	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
644801002246	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
644801002247	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
644801002248	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
644801002249	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
644801002250	replicative DNA helicase; Provisional; Region: PRK05748
644801002251	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
644801002252	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
644801002253	Walker A motif; other site
644801002254	ATP binding site [chemical binding]; other site
644801002255	Walker B motif; other site
644801002256	DNA binding loops [nucleotide binding]
644801002257	alanine racemase; Reviewed; Region: alr; PRK00053
644801002258	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
644801002259	active site
644801002260	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
644801002261	substrate binding site [chemical binding]; other site
644801002262	catalytic residues [active]
644801002263	dimer interface [polypeptide binding]; other site
644801002264	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
644801002265	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
644801002266	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
644801002267	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801002268	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801002269	metal binding site [ion binding]; metal-binding site
644801002270	active site
644801002271	I-site; other site
644801002272	hypothetical protein; Provisional; Region: PRK01254
644801002273	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
644801002274	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
644801002275	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801002276	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801002277	dimer interface [polypeptide binding]; other site
644801002278	putative CheW interface [polypeptide binding]; other site
644801002279	Response regulator receiver domain; Region: Response_reg; pfam00072
644801002280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002281	active site
644801002282	phosphorylation site [posttranslational modification]
644801002283	intermolecular recognition site; other site
644801002284	dimerization interface [polypeptide binding]; other site
644801002285	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801002286	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801002287	metal binding site [ion binding]; metal-binding site
644801002288	active site
644801002289	I-site; other site
644801002290	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
644801002291	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801002292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002293	active site
644801002294	phosphorylation site [posttranslational modification]
644801002295	intermolecular recognition site; other site
644801002296	dimerization interface [polypeptide binding]; other site
644801002297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002298	Walker A motif; other site
644801002299	ATP binding site [chemical binding]; other site
644801002300	Walker B motif; other site
644801002301	arginine finger; other site
644801002302	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801002303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801002304	dimer interface [polypeptide binding]; other site
644801002305	phosphorylation site [posttranslational modification]
644801002306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801002307	ATP binding site [chemical binding]; other site
644801002308	Mg2+ binding site [ion binding]; other site
644801002309	G-X-G motif; other site
644801002310	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
644801002311	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
644801002312	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801002313	RNA binding surface [nucleotide binding]; other site
644801002314	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
644801002315	active site
644801002316	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
644801002317	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
644801002318	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
644801002319	Clp amino terminal domain; Region: Clp_N; pfam02861
644801002320	Clp amino terminal domain; Region: Clp_N; pfam02861
644801002321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002322	Walker A motif; other site
644801002323	ATP binding site [chemical binding]; other site
644801002324	Walker B motif; other site
644801002325	arginine finger; other site
644801002326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002327	Walker A motif; other site
644801002328	ATP binding site [chemical binding]; other site
644801002329	Walker B motif; other site
644801002330	arginine finger; other site
644801002331	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
644801002332	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
644801002333	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
644801002334	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
644801002335	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
644801002336	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
644801002337	dimerization interface [polypeptide binding]; other site
644801002338	active site
644801002339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
644801002340	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
644801002341	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
644801002342	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
644801002343	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
644801002344	active site
644801002345	HIGH motif; other site
644801002346	dimer interface [polypeptide binding]; other site
644801002347	KMSKS motif; other site
644801002348	Predicted ATPase [General function prediction only]; Region: COG1485
644801002349	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
644801002350	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
644801002351	conserved cys residue [active]
644801002352	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002353	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
644801002354	Active_site [active]
644801002355	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
644801002356	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
644801002357	amidase catalytic site [active]
644801002358	Zn binding residues [ion binding]; other site
644801002359	substrate binding site [chemical binding]; other site
644801002360	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
644801002361	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801002362	dimerization interface [polypeptide binding]; other site
644801002363	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801002364	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801002365	dimer interface [polypeptide binding]; other site
644801002366	putative CheW interface [polypeptide binding]; other site
644801002367	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
644801002368	active site
644801002369	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
644801002370	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
644801002371	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002372	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
644801002373	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
644801002374	DNA binding site [nucleotide binding]
644801002375	active site
644801002376	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
644801002377	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
644801002378	ATP binding site [chemical binding]; other site
644801002379	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
644801002380	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
644801002381	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
644801002382	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801002383	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801002384	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
644801002385	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
644801002386	heme binding site [chemical binding]; other site
644801002387	ferroxidase pore; other site
644801002388	ferroxidase diiron center [ion binding]; other site
644801002389	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
644801002390	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801002391	dimerization interface [polypeptide binding]; other site
644801002392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801002393	dimer interface [polypeptide binding]; other site
644801002394	putative CheW interface [polypeptide binding]; other site
644801002395	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
644801002396	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
644801002397	DNA binding residues [nucleotide binding]
644801002398	dimer interface [polypeptide binding]; other site
644801002399	copper binding site [ion binding]; other site
644801002400	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801002401	metal-binding site [ion binding]
644801002402	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
644801002403	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801002404	metal-binding site [ion binding]
644801002405	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801002406	Soluble P-type ATPase [General function prediction only]; Region: COG4087
644801002407	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801002408	metal-binding site [ion binding]
644801002409	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
644801002410	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801002411	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
644801002412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801002413	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
644801002414	putative substrate translocation pore; other site
644801002415	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
644801002416	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
644801002417	active site
644801002418	purine riboside binding site [chemical binding]; other site
644801002419	Uncharacterized conserved protein [Function unknown]; Region: COG1739
644801002420	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
644801002421	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
644801002422	dimerization interface [polypeptide binding]; other site
644801002423	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
644801002424	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
644801002425	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
644801002426	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
644801002427	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
644801002428	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
644801002429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801002430	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
644801002431	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
644801002432	active site
644801002433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801002434	Major Facilitator Superfamily; Region: MFS_1; pfam07690
644801002435	putative substrate translocation pore; other site
644801002436	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
644801002437	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
644801002438	conserved cys residue [active]
644801002439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002441	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801002442	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
644801002443	FMN binding site [chemical binding]; other site
644801002444	active site
644801002445	substrate binding site [chemical binding]; other site
644801002446	catalytic residue [active]
644801002447	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801002448	dimerization interface [polypeptide binding]; other site
644801002449	putative DNA binding site [nucleotide binding]; other site
644801002450	putative Zn2+ binding site [ion binding]; other site
644801002451	Helix-turn-helix domain; Region: HTH_18; pfam12833
644801002452	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002453	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
644801002454	Uncharacterized conserved protein [Function unknown]; Region: COG2128
644801002455	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
644801002456	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801002457	putative metal binding site [ion binding]; other site
644801002458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801002459	S-adenosylmethionine binding site [chemical binding]; other site
644801002460	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
644801002461	hydrophobic ligand binding site; other site
644801002462	EamA-like transporter family; Region: EamA; cl17759
644801002463	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
644801002464	EamA-like transporter family; Region: EamA; pfam00892
644801002465	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
644801002466	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
644801002467	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
644801002468	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801002469	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801002470	metal binding site [ion binding]; metal-binding site
644801002471	active site
644801002472	I-site; other site
644801002473	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801002474	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801002475	substrate binding pocket [chemical binding]; other site
644801002476	membrane-bound complex binding site; other site
644801002477	hinge residues; other site
644801002478	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801002479	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801002480	metal binding site [ion binding]; metal-binding site
644801002481	active site
644801002482	I-site; other site
644801002483	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
644801002484	putative metal binding site [ion binding]; other site
644801002485	Uncharacterized conserved protein [Function unknown]; Region: COG1432
644801002486	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
644801002487	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801002488	DNA-binding site [nucleotide binding]; DNA binding site
644801002489	RNA-binding motif; other site
644801002490	Predicted membrane protein [Function unknown]; Region: COG3326
644801002491	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
644801002492	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
644801002493	PhnA protein; Region: PhnA; pfam03831
644801002494	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
644801002495	Cytochrome c; Region: Cytochrom_C; cl11414
644801002496	Cytochrome c; Region: Cytochrom_C; cl11414
644801002497	cytosine deaminase; Provisional; Region: PRK09230
644801002498	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
644801002499	active site
644801002500	cytosine permease; Provisional; Region: codB; PRK11017
644801002501	Na binding site [ion binding]; other site
644801002502	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
644801002503	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
644801002504	tetramer interface [polypeptide binding]; other site
644801002505	heme binding pocket [chemical binding]; other site
644801002506	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
644801002507	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
644801002508	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
644801002509	cyanate hydratase; Validated; Region: PRK02866
644801002510	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
644801002511	oligomer interface [polypeptide binding]; other site
644801002512	active site
644801002513	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
644801002514	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
644801002515	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801002516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801002517	homodimer interface [polypeptide binding]; other site
644801002518	catalytic residue [active]
644801002519	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
644801002520	aromatic arch; other site
644801002521	DCoH dimer interaction site [polypeptide binding]; other site
644801002522	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
644801002523	DCoH tetramer interaction site [polypeptide binding]; other site
644801002524	substrate binding site [chemical binding]; other site
644801002525	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
644801002526	cofactor binding site; other site
644801002527	metal binding site [ion binding]; metal-binding site
644801002528	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
644801002529	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
644801002530	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801002531	putative active site [active]
644801002532	heme pocket [chemical binding]; other site
644801002533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002534	Walker A motif; other site
644801002535	ATP binding site [chemical binding]; other site
644801002536	Walker B motif; other site
644801002537	arginine finger; other site
644801002538	CheB methylesterase; Region: CheB_methylest; pfam01339
644801002539	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
644801002540	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
644801002541	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
644801002542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801002543	PAS domain; Region: PAS_9; pfam13426
644801002544	putative active site [active]
644801002545	heme pocket [chemical binding]; other site
644801002546	Tat binding protein 1(TBP-1)-interacting protein (TBPIP); Region: TBPIP; pfam07106
644801002547	PAS domain; Region: PAS_10; pfam13596
644801002548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
644801002549	putative active site [active]
644801002550	heme pocket [chemical binding]; other site
644801002551	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
644801002552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801002553	putative active site [active]
644801002554	heme pocket [chemical binding]; other site
644801002555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801002556	dimer interface [polypeptide binding]; other site
644801002557	phosphorylation site [posttranslational modification]
644801002558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801002559	ATP binding site [chemical binding]; other site
644801002560	Mg2+ binding site [ion binding]; other site
644801002561	G-X-G motif; other site
644801002562	Response regulator receiver domain; Region: Response_reg; pfam00072
644801002563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801002564	active site
644801002565	phosphorylation site [posttranslational modification]
644801002566	intermolecular recognition site; other site
644801002567	dimerization interface [polypeptide binding]; other site
644801002568	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
644801002569	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
644801002570	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
644801002571	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
644801002572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801002573	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801002574	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801002575	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801002576	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801002577	Uncharacterized conserved protein [Function unknown]; Region: COG3189
644801002578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399
644801002579	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801002580	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801002581	active site
644801002582	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
644801002583	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
644801002584	4Fe-4S binding domain; Region: Fer4_5; pfam12801
644801002585	nitrous-oxide reductase; Validated; Region: PRK02888
644801002586	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
644801002587	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
644801002588	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
644801002589	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
644801002590	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
644801002591	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801002592	Walker A/P-loop; other site
644801002593	ATP binding site [chemical binding]; other site
644801002594	Q-loop/lid; other site
644801002595	ABC transporter signature motif; other site
644801002596	Walker B; other site
644801002597	D-loop; other site
644801002598	H-loop/switch region; other site
644801002599	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
644801002600	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
644801002601	NosL; Region: NosL; pfam05573
644801002602	twin arginine translocase protein A; Provisional; Region: tatA; PRK04598
644801002603	NnrS protein; Region: NnrS; pfam05940
644801002604	short chain dehydrogenase; Provisional; Region: PRK06500
644801002605	classical (c) SDRs; Region: SDR_c; cd05233
644801002606	NAD(P) binding site [chemical binding]; other site
644801002607	active site
644801002608	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
644801002609	HPP family; Region: HPP; pfam04982
644801002610	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
644801002611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801002612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801002613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
644801002614	dimerization interface [polypeptide binding]; other site
644801002615	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801002616	Type II transport protein GspH; Region: GspH; pfam12019
644801002617	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
644801002618	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
644801002619	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
644801002620	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
644801002621	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
644801002622	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
644801002623	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801002624	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
644801002625	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
644801002626	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
644801002627	active site
644801002628	SAM binding site [chemical binding]; other site
644801002629	homodimer interface [polypeptide binding]; other site
644801002630	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
644801002631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801002632	FeS/SAM binding site; other site
644801002633	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
644801002634	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
644801002635	Subunit I/III interface [polypeptide binding]; other site
644801002636	MoxR-like ATPases [General function prediction only]; Region: COG0714
644801002637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002638	Walker A motif; other site
644801002639	ATP binding site [chemical binding]; other site
644801002640	Walker B motif; other site
644801002641	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
644801002642	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
644801002643	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801002644	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
644801002645	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
644801002646	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
644801002647	Ethylbenzene dehydrogenase; Region: EB_dh; smart00887
644801002648	putative ligand binding site [chemical binding]; other site
644801002649	Cytochrome c; Region: Cytochrom_C; cl11414
644801002650	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
644801002651	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801002652	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
644801002653	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801002654	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801002655	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801002656	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
644801002657	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801002658	Cytochrome c; Region: Cytochrom_C; pfam00034
644801002659	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
644801002660	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
644801002661	Low-spin heme binding site [chemical binding]; other site
644801002662	D-pathway; other site
644801002663	K-pathway; other site
644801002664	Binuclear center (active site) [active]
644801002665	Putative proton exit pathway; other site
644801002666	Putative water exit pathway; other site
644801002667	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
644801002668	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
644801002669	metal ion-dependent adhesion site (MIDAS); other site
644801002670	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
644801002671	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801002672	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801002673	ligand binding site [chemical binding]; other site
644801002674	flexible hinge region; other site
644801002675	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
644801002676	putative switch regulator; other site
644801002677	non-specific DNA interactions [nucleotide binding]; other site
644801002678	DNA binding site [nucleotide binding]
644801002679	sequence specific DNA binding site [nucleotide binding]; other site
644801002680	putative cAMP binding site [chemical binding]; other site
644801002681	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
644801002682	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
644801002683	Hemerythrin-like domain; Region: Hr-like; cd12108
644801002684	Fe binding site [ion binding]; other site
644801002685	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
644801002686	GAF domain; Region: GAF; pfam01590
644801002687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801002688	Walker A motif; other site
644801002689	ATP binding site [chemical binding]; other site
644801002690	Walker B motif; other site
644801002691	arginine finger; other site
644801002692	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
644801002693	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
644801002694	Peptidase family U32; Region: Peptidase_U32; pfam01136
644801002695	putative protease; Provisional; Region: PRK15447
644801002696	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
644801002697	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
644801002698	DGC domain; Region: DGC; pfam08859
644801002699	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801002700	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801002701	ligand binding site [chemical binding]; other site
644801002702	flexible hinge region; other site
644801002703	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
644801002704	putative switch regulator; other site
644801002705	non-specific DNA interactions [nucleotide binding]; other site
644801002706	DNA binding site [nucleotide binding]
644801002707	sequence specific DNA binding site [nucleotide binding]; other site
644801002708	putative cAMP binding site [chemical binding]; other site
644801002709	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
644801002710	ATP cone domain; Region: ATP-cone; pfam03477
644801002711	Class III ribonucleotide reductase; Region: RNR_III; cd01675
644801002712	effector binding site; other site
644801002713	active site
644801002714	Zn binding site [ion binding]; other site
644801002715	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
644801002716	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
644801002717	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801002718	FeS/SAM binding site; other site
644801002719	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
644801002720	4Fe-4S binding domain; Region: Fer4_5; pfam12801
644801002721	Iron permease FTR1 family; Region: FTR1; cl00475
644801002722	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
644801002723	Fe2+ transport protein; Region: Iron_transport; pfam10634
644801002724	putative transporter; Provisional; Region: PRK10504
644801002725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801002726	putative substrate translocation pore; other site
644801002727	Pathogenicity factor; Region: AvrE; pfam11725
644801002728	phosphogluconate dehydratase; Validated; Region: PRK09054
644801002729	6-phosphogluconate dehydratase; Region: edd; TIGR01196
644801002730	glucokinase; Provisional; Region: glk; PRK00292
644801002731	glucokinase, proteobacterial type; Region: glk; TIGR00749
644801002732	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
644801002733	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
644801002734	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
644801002735	putative active site [active]
644801002736	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
644801002737	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
644801002738	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
644801002739	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
644801002740	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
644801002741	putative active site [active]
644801002742	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
644801002743	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
644801002744	active site
644801002745	intersubunit interface [polypeptide binding]; other site
644801002746	catalytic residue [active]
644801002747	betaine aldehyde dehydrogenase; Region: PLN02467
644801002748	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
644801002749	tetrameric interface [polypeptide binding]; other site
644801002750	activator binding site; other site
644801002751	NADP binding site [chemical binding]; other site
644801002752	substrate binding site [chemical binding]; other site
644801002753	catalytic residues [active]
644801002754	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
644801002755	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
644801002756	active site
644801002757	catalytic tetrad [active]
644801002758	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
644801002759	Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148
644801002760	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
644801002761	trimer interface; other site
644801002762	sugar binding site [chemical binding]; other site
644801002763	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
644801002764	active site
644801002765	Ca binding site [ion binding]; other site
644801002766	catalytic site [active]
644801002767	Domain of unknown function (DUF1921); Region: DUF1921; pfam09081
644801002768	Glucan 1,4-alpha-maltotetraohydrolase (alpha-MTH), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from...; Region: CBM20_alpha_MTH; cd05810
644801002769	starch-binding site 2 [chemical binding]; other site
644801002770	starch-binding site 1 [chemical binding]; other site
644801002771	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
644801002772	active site
644801002773	substrate binding site [chemical binding]; other site
644801002774	ATP binding site [chemical binding]; other site
644801002775	alpha-amylase; Reviewed; Region: malS; PRK09505
644801002776	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
644801002777	active site
644801002778	catalytic site [active]
644801002779	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
644801002780	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
644801002781	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
644801002782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801002783	dimer interface [polypeptide binding]; other site
644801002784	conserved gate region; other site
644801002785	putative PBP binding loops; other site
644801002786	ABC-ATPase subunit interface; other site
644801002787	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
644801002788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801002789	dimer interface [polypeptide binding]; other site
644801002790	conserved gate region; other site
644801002791	putative PBP binding loops; other site
644801002792	ABC-ATPase subunit interface; other site
644801002793	transcriptional regulator MalT; Provisional; Region: PRK04841
644801002794	AAA ATPase domain; Region: AAA_16; pfam13191
644801002795	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801002796	DNA binding residues [nucleotide binding]
644801002797	dimerization interface [polypeptide binding]; other site
644801002798	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801002799	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
644801002800	C-terminal domain interface [polypeptide binding]; other site
644801002801	GSH binding site (G-site) [chemical binding]; other site
644801002802	dimer interface [polypeptide binding]; other site
644801002803	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
644801002804	dimer interface [polypeptide binding]; other site
644801002805	N-terminal domain interface [polypeptide binding]; other site
644801002806	substrate binding pocket (H-site) [chemical binding]; other site
644801002807	maltose O-acetyltransferase; Provisional; Region: PRK10092
644801002808	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
644801002809	active site
644801002810	substrate binding site [chemical binding]; other site
644801002811	trimer interface [polypeptide binding]; other site
644801002812	CoA binding site [chemical binding]; other site
644801002813	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
644801002814	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
644801002815	active site
644801002816	catalytic site [active]
644801002817	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
644801002818	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
644801002819	Walker A/P-loop; other site
644801002820	ATP binding site [chemical binding]; other site
644801002821	Q-loop/lid; other site
644801002822	ABC transporter signature motif; other site
644801002823	Walker B; other site
644801002824	D-loop; other site
644801002825	H-loop/switch region; other site
644801002826	TOBE domain; Region: TOBE_2; pfam08402
644801002827	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801002828	non-specific DNA binding site [nucleotide binding]; other site
644801002829	salt bridge; other site
644801002830	sequence-specific DNA binding site [nucleotide binding]; other site
644801002831	HipA N-terminal domain; Region: Couple_hipA; pfam13657
644801002832	HipA-like N-terminal domain; Region: HipA_N; pfam07805
644801002833	HipA-like C-terminal domain; Region: HipA_C; pfam07804
644801002834	HsdM N-terminal domain; Region: HsdM_N; pfam12161
644801002835	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
644801002836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801002837	S-adenosylmethionine binding site [chemical binding]; other site
644801002838	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
644801002839	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
644801002840	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
644801002841	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
644801002842	Mrr N-terminal domain; Region: Mrr_N; pfam14338
644801002843	Restriction endonuclease; Region: Mrr_cat; pfam04471
644801002844	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801002845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801002846	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801002847	dimerization interface [polypeptide binding]; other site
644801002848	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
644801002849	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
644801002850	putative NAD(P) binding site [chemical binding]; other site
644801002851	putative regulator PrlF; Provisional; Region: PRK09974
644801002852	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
644801002853	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
644801002854	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
644801002855	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
644801002856	conserved cys residue [active]
644801002857	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002858	Protein of unknown function (DUF3422); Region: DUF3422; cl02073
644801002859	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801002860	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
644801002861	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
644801002862	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
644801002863	substrate binding site [chemical binding]; other site
644801002864	catalytic Zn binding site [ion binding]; other site
644801002865	NAD binding site [chemical binding]; other site
644801002866	structural Zn binding site [ion binding]; other site
644801002867	dimer interface [polypeptide binding]; other site
644801002868	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
644801002869	putative homodimer interface [polypeptide binding]; other site
644801002870	putative homotetramer interface [polypeptide binding]; other site
644801002871	putative metal binding site [ion binding]; other site
644801002872	putative homodimer-homodimer interface [polypeptide binding]; other site
644801002873	putative allosteric switch controlling residues; other site
644801002874	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
644801002875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801002876	NAD(P) binding site [chemical binding]; other site
644801002877	active site
644801002878	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801002879	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801002880	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801002881	putative effector binding pocket; other site
644801002882	dimerization interface [polypeptide binding]; other site
644801002883	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
644801002884	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
644801002885	NAD binding site [chemical binding]; other site
644801002886	catalytic Zn binding site [ion binding]; other site
644801002887	structural Zn binding site [ion binding]; other site
644801002888	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
644801002889	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801002890	Walker A/P-loop; other site
644801002891	ATP binding site [chemical binding]; other site
644801002892	Q-loop/lid; other site
644801002893	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
644801002894	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801002895	AAA domain; Region: AAA_21; pfam13304
644801002896	Walker A/P-loop; other site
644801002897	ATP binding site [chemical binding]; other site
644801002898	Q-loop/lid; other site
644801002899	ABC transporter signature motif; other site
644801002900	Walker B; other site
644801002901	D-loop; other site
644801002902	H-loop/switch region; other site
644801002903	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801002904	dimerization interface [polypeptide binding]; other site
644801002905	putative DNA binding site [nucleotide binding]; other site
644801002906	putative Zn2+ binding site [ion binding]; other site
644801002907	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
644801002908	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
644801002909	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801002910	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
644801002911	FMN binding site [chemical binding]; other site
644801002912	active site
644801002913	substrate binding site [chemical binding]; other site
644801002914	catalytic residue [active]
644801002915	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
644801002916	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
644801002917	NAD(P) binding site [chemical binding]; other site
644801002918	catalytic residues [active]
644801002919	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
644801002920	active site
644801002921	catalytic site [active]
644801002922	substrate binding site [chemical binding]; other site
644801002923	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
644801002924	tellurite resistance protein terB; Region: terB; cd07176
644801002925	putative metal binding site [ion binding]; other site
644801002926	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
644801002927	DEAD-like helicases superfamily; Region: DEXDc; smart00487
644801002928	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801002929	ATP binding site [chemical binding]; other site
644801002930	putative Mg++ binding site [ion binding]; other site
644801002931	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801002932	nucleotide binding region [chemical binding]; other site
644801002933	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801002934	active site
644801002935	catalytic residues [active]
644801002936	DNA binding site [nucleotide binding]
644801002937	Int/Topo IB signature motif; other site
644801002938	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
644801002939	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
644801002940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
644801002941	TPR motif; other site
644801002942	binding surface
644801002943	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
644801002944	EamA-like transporter family; Region: EamA; pfam00892
644801002945	EamA-like transporter family; Region: EamA; pfam00892
644801002946	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
644801002947	EamA-like transporter family; Region: EamA; pfam00892
644801002948	EamA-like transporter family; Region: EamA; pfam00892
644801002949	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801002950	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
644801002951	putative DNA binding site [nucleotide binding]; other site
644801002952	putative Zn2+ binding site [ion binding]; other site
644801002953	AsnC family; Region: AsnC_trans_reg; pfam01037
644801002954	Cupin; Region: Cupin_6; pfam12852
644801002955	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801002956	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801002958	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
644801002959	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
644801002960	GSH binding site [chemical binding]; other site
644801002961	catalytic residues [active]
644801002962	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
644801002963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801002964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801002965	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801002966	putative effector binding pocket; other site
644801002967	dimerization interface [polypeptide binding]; other site
644801002968	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
644801002969	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
644801002970	putative NAD(P) binding site [chemical binding]; other site
644801002971	dimer interface [polypeptide binding]; other site
644801002972	Major royal jelly protein; Region: MRJP; pfam03022
644801002973	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
644801002974	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
644801002975	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
644801002976	dimer interface [polypeptide binding]; other site
644801002977	FMN binding site [chemical binding]; other site
644801002978	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
644801002979	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
644801002980	NADP binding site [chemical binding]; other site
644801002981	dimer interface [polypeptide binding]; other site
644801002982	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801002983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801002984	AAA domain; Region: AAA_21; pfam13304
644801002985	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
644801002986	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
644801002987	putative homodimer interface [polypeptide binding]; other site
644801002988	putative homotetramer interface [polypeptide binding]; other site
644801002989	putative metal binding site [ion binding]; other site
644801002990	putative homodimer-homodimer interface [polypeptide binding]; other site
644801002991	putative allosteric switch controlling residues; other site
644801002992	High-affinity nickel-transport protein; Region: NicO; cl00964
644801002993	High-affinity nickel-transport protein; Region: NicO; cl00964
644801002994	Predicted membrane protein [Function unknown]; Region: COG1238
644801002995	conjugal transfer protein TrbP; Provisional; Region: PRK13882
644801002996	TraX protein; Region: TraX; pfam05857
644801002997	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
644801002998	active site residue [active]
644801002999	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
644801003000	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
644801003001	Chromate transporter; Region: Chromate_transp; pfam02417
644801003002	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
644801003003	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801003004	active site
644801003005	DNA binding site [nucleotide binding]
644801003006	Int/Topo IB signature motif; other site
644801003007	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
644801003008	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801003009	active site
644801003010	DNA binding site [nucleotide binding]
644801003011	Int/Topo IB signature motif; other site
644801003012	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
644801003013	FAD binding domain; Region: FAD_binding_4; pfam01565
644801003014	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
644801003015	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
644801003016	Cysteine-rich domain; Region: CCG; pfam02754
644801003017	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
644801003018	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
644801003019	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
644801003020	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
644801003021	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
644801003022	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
644801003023	Cysteine-rich domain; Region: CCG; pfam02754
644801003024	Cysteine-rich domain; Region: CCG; pfam02754
644801003025	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
644801003026	L-lactate permease; Region: Lactate_perm; cl00701
644801003027	Transcriptional regulators [Transcription]; Region: FadR; COG2186
644801003028	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801003029	DNA-binding site [nucleotide binding]; DNA binding site
644801003030	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
644801003031	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
644801003032	SmpB-tmRNA interface; other site
644801003033	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
644801003034	putative coenzyme Q binding site [chemical binding]; other site
644801003035	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
644801003036	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
644801003037	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
644801003038	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
644801003039	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
644801003040	metal binding site 2 [ion binding]; metal-binding site
644801003041	putative DNA binding helix; other site
644801003042	metal binding site 1 [ion binding]; metal-binding site
644801003043	dimer interface [polypeptide binding]; other site
644801003044	structural Zn2+ binding site [ion binding]; other site
644801003045	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
644801003046	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
644801003047	Walker A/P-loop; other site
644801003048	ATP binding site [chemical binding]; other site
644801003049	Q-loop/lid; other site
644801003050	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
644801003051	ABC transporter signature motif; other site
644801003052	Walker B; other site
644801003053	D-loop; other site
644801003054	H-loop/switch region; other site
644801003055	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
644801003056	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
644801003057	dimer interface [polypeptide binding]; other site
644801003058	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
644801003059	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
644801003060	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
644801003061	nucleotide binding site [chemical binding]; other site
644801003062	NEF interaction site [polypeptide binding]; other site
644801003063	SBD interface [polypeptide binding]; other site
644801003064	chaperone protein DnaJ; Provisional; Region: PRK10767
644801003065	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
644801003066	HSP70 interaction site [polypeptide binding]; other site
644801003067	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
644801003068	substrate binding site [polypeptide binding]; other site
644801003069	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
644801003070	Zn binding sites [ion binding]; other site
644801003071	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
644801003072	dimer interface [polypeptide binding]; other site
644801003073	dihydrodipicolinate reductase; Provisional; Region: PRK00048
644801003074	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
644801003075	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
644801003076	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
644801003077	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
644801003078	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
644801003079	catalytic site [active]
644801003080	subunit interface [polypeptide binding]; other site
644801003081	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
644801003082	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
644801003083	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
644801003084	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
644801003085	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
644801003086	ATP-grasp domain; Region: ATP-grasp_4; cl17255
644801003087	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
644801003088	IMP binding site; other site
644801003089	dimer interface [polypeptide binding]; other site
644801003090	interdomain contacts; other site
644801003091	partial ornithine binding site; other site
644801003092	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
644801003093	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
644801003094	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
644801003095	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
644801003096	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
644801003097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801003098	Walker A motif; other site
644801003099	ATP binding site [chemical binding]; other site
644801003100	Walker B motif; other site
644801003101	arginine finger; other site
644801003102	Peptidase family M41; Region: Peptidase_M41; pfam01434
644801003103	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
644801003104	dihydropteroate synthase; Region: DHPS; TIGR01496
644801003105	substrate binding pocket [chemical binding]; other site
644801003106	dimer interface [polypeptide binding]; other site
644801003107	inhibitor binding site; inhibition site
644801003108	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
644801003109	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
644801003110	active site
644801003111	substrate binding site [chemical binding]; other site
644801003112	metal binding site [ion binding]; metal-binding site
644801003113	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
644801003114	triosephosphate isomerase; Provisional; Region: PRK14567
644801003115	substrate binding site [chemical binding]; other site
644801003116	dimer interface [polypeptide binding]; other site
644801003117	catalytic triad [active]
644801003118	ribosome maturation protein RimP; Reviewed; Region: PRK00092
644801003119	Sm and related proteins; Region: Sm_like; cl00259
644801003120	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
644801003121	putative oligomer interface [polypeptide binding]; other site
644801003122	putative RNA binding site [nucleotide binding]; other site
644801003123	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
644801003124	NusA N-terminal domain; Region: NusA_N; pfam08529
644801003125	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
644801003126	RNA binding site [nucleotide binding]; other site
644801003127	homodimer interface [polypeptide binding]; other site
644801003128	NusA-like KH domain; Region: KH_5; pfam13184
644801003129	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
644801003130	G-X-X-G motif; other site
644801003131	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
644801003132	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
644801003133	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
644801003134	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
644801003135	translation initiation factor IF-2; Region: IF-2; TIGR00487
644801003136	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
644801003137	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
644801003138	G1 box; other site
644801003139	putative GEF interaction site [polypeptide binding]; other site
644801003140	GTP/Mg2+ binding site [chemical binding]; other site
644801003141	Switch I region; other site
644801003142	G2 box; other site
644801003143	G3 box; other site
644801003144	Switch II region; other site
644801003145	G4 box; other site
644801003146	G5 box; other site
644801003147	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
644801003148	Translation-initiation factor 2; Region: IF-2; pfam11987
644801003149	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
644801003150	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
644801003151	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
644801003152	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
644801003153	RNA binding site [nucleotide binding]; other site
644801003154	active site
644801003155	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
644801003156	Ribosomal S15 leader; Psest_0984
644801003157	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
644801003158	16S/18S rRNA binding site [nucleotide binding]; other site
644801003159	S13e-L30e interaction site [polypeptide binding]; other site
644801003160	25S rRNA binding site [nucleotide binding]; other site
644801003161	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
644801003162	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
644801003163	RNase E interface [polypeptide binding]; other site
644801003164	trimer interface [polypeptide binding]; other site
644801003165	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
644801003166	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
644801003167	RNase E interface [polypeptide binding]; other site
644801003168	trimer interface [polypeptide binding]; other site
644801003169	active site
644801003170	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
644801003171	putative nucleic acid binding region [nucleotide binding]; other site
644801003172	G-X-X-G motif; other site
644801003173	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
644801003174	RNA binding site [nucleotide binding]; other site
644801003175	domain interface; other site
644801003176	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
644801003177	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
644801003178	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
644801003179	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
644801003180	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
644801003181	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
644801003182	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801003183	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
644801003184	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
644801003185	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
644801003186	putative RNA binding site [nucleotide binding]; other site
644801003187	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
644801003188	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
644801003189	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
644801003190	active site
644801003191	dimer interface [polypeptide binding]; other site
644801003192	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
644801003193	dimer interface [polypeptide binding]; other site
644801003194	active site
644801003195	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
644801003196	tetramerization interface [polypeptide binding]; other site
644801003197	active site
644801003198	pantoate--beta-alanine ligase; Region: panC; TIGR00018
644801003199	Pantoate-beta-alanine ligase; Region: PanC; cd00560
644801003200	active site
644801003201	ATP-binding site [chemical binding]; other site
644801003202	pantoate-binding site; other site
644801003203	HXXH motif; other site
644801003204	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
644801003205	oligomerization interface [polypeptide binding]; other site
644801003206	active site
644801003207	metal binding site [ion binding]; metal-binding site
644801003208	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
644801003209	catalytic center binding site [active]
644801003210	ATP binding site [chemical binding]; other site
644801003211	poly(A) polymerase; Region: pcnB; TIGR01942
644801003212	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
644801003213	active site
644801003214	NTP binding site [chemical binding]; other site
644801003215	metal binding triad [ion binding]; metal-binding site
644801003216	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
644801003217	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
644801003218	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801003219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801003220	active site
644801003221	phosphorylation site [posttranslational modification]
644801003222	intermolecular recognition site; other site
644801003223	dimerization interface [polypeptide binding]; other site
644801003224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801003225	Walker A motif; other site
644801003226	ATP binding site [chemical binding]; other site
644801003227	Walker B motif; other site
644801003228	arginine finger; other site
644801003229	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
644801003230	Na binding site [ion binding]; other site
644801003231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801003232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801003233	dimer interface [polypeptide binding]; other site
644801003234	phosphorylation site [posttranslational modification]
644801003235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801003236	ATP binding site [chemical binding]; other site
644801003237	Mg2+ binding site [ion binding]; other site
644801003238	G-X-G motif; other site
644801003239	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
644801003240	active site
644801003241	HIGH motif; other site
644801003242	nucleotide binding site [chemical binding]; other site
644801003243	KMSKS motif; other site
644801003244	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
644801003245	hypothetical protein; Provisional; Region: PRK08960
644801003246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801003247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801003248	homodimer interface [polypeptide binding]; other site
644801003249	catalytic residue [active]
644801003250	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
644801003251	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
644801003252	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
644801003253	NADP binding site [chemical binding]; other site
644801003254	active site
644801003255	putative substrate binding site [chemical binding]; other site
644801003256	Predicted permeases [General function prediction only]; Region: COG0679
644801003257	Predicted integral membrane protein [Function unknown]; Region: COG0392
644801003258	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
644801003259	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
644801003260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801003261	dimer interface [polypeptide binding]; other site
644801003262	phosphorylation site [posttranslational modification]
644801003263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801003264	ATP binding site [chemical binding]; other site
644801003265	Mg2+ binding site [ion binding]; other site
644801003266	G-X-G motif; other site
644801003267	Response regulator receiver domain; Region: Response_reg; pfam00072
644801003268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801003269	active site
644801003270	phosphorylation site [posttranslational modification]
644801003271	intermolecular recognition site; other site
644801003272	dimerization interface [polypeptide binding]; other site
644801003273	Response regulator receiver domain; Region: Response_reg; pfam00072
644801003274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801003275	active site
644801003276	phosphorylation site [posttranslational modification]
644801003277	intermolecular recognition site; other site
644801003278	dimerization interface [polypeptide binding]; other site
644801003279	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
644801003280	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
644801003281	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
644801003282	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
644801003283	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
644801003284	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
644801003285	purine monophosphate binding site [chemical binding]; other site
644801003286	dimer interface [polypeptide binding]; other site
644801003287	putative catalytic residues [active]
644801003288	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
644801003289	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
644801003290	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
644801003291	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
644801003292	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
644801003293	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
644801003294	FMN binding site [chemical binding]; other site
644801003295	active site
644801003296	catalytic residues [active]
644801003297	substrate binding site [chemical binding]; other site
644801003298	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
644801003299	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
644801003300	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
644801003301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801003302	S-adenosylmethionine binding site [chemical binding]; other site
644801003303	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
644801003304	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
644801003305	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
644801003306	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
644801003307	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
644801003308	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
644801003309	carboxyltransferase (CT) interaction site; other site
644801003310	biotinylation site [posttranslational modification]; other site
644801003311	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
644801003312	Dehydroquinase class II; Region: DHquinase_II; pfam01220
644801003313	active site
644801003314	trimer interface [polypeptide binding]; other site
644801003315	dimer interface [polypeptide binding]; other site
644801003316	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
644801003317	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
644801003318	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
644801003319	DsbD alpha interface [polypeptide binding]; other site
644801003320	catalytic residues [active]
644801003321	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
644801003322	iron-sulfur cluster [ion binding]; other site
644801003323	[2Fe-2S] cluster binding site [ion binding]; other site
644801003324	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
644801003325	ABC-ATPase subunit  interface; other site
644801003326	dimer interface [polypeptide binding]; other site
644801003327	putative PBP binding regions; other site
644801003328	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
644801003329	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
644801003330	Walker A/P-loop; other site
644801003331	ATP binding site [chemical binding]; other site
644801003332	Q-loop/lid; other site
644801003333	ABC transporter signature motif; other site
644801003334	Walker B; other site
644801003335	D-loop; other site
644801003336	H-loop/switch region; other site
644801003337	Protein of unknown function, DUF399; Region: DUF399; cl01139
644801003338	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801003339	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801003340	ligand binding site [chemical binding]; other site
644801003341	flexible hinge region; other site
644801003342	TfoX C-terminal domain; Region: TfoX_C; pfam04994
644801003343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801003344	S-adenosylmethionine binding site [chemical binding]; other site
644801003345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
644801003346	AAA domain; Region: AAA_33; pfam13671
644801003347	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
644801003348	active site
644801003349	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
644801003350	Transglycosylase; Region: Transgly; pfam00912
644801003351	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
644801003352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801003353	TPR motif; other site
644801003354	binding surface
644801003355	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
644801003356	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801003357	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
644801003358	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
644801003359	PYR/PP interface [polypeptide binding]; other site
644801003360	dimer interface [polypeptide binding]; other site
644801003361	TPP binding site [chemical binding]; other site
644801003362	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
644801003363	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
644801003364	TPP-binding site [chemical binding]; other site
644801003365	dimer interface [polypeptide binding]; other site
644801003366	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
644801003367	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
644801003368	putative valine binding site [chemical binding]; other site
644801003369	dimer interface [polypeptide binding]; other site
644801003370	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
644801003371	ketol-acid reductoisomerase; Provisional; Region: PRK05479
644801003372	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
644801003373	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
644801003374	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
644801003375	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
644801003376	TMAO/DMSO reductase; Reviewed; Region: PRK05363
644801003377	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
644801003378	Moco binding site; other site
644801003379	metal coordination site [ion binding]; other site
644801003380	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
644801003381	Paraquat-inducible protein A; Region: PqiA; pfam04403
644801003382	Paraquat-inducible protein A; Region: PqiA; pfam04403
644801003383	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
644801003384	mce related protein; Region: MCE; pfam02470
644801003385	mce related protein; Region: MCE; pfam02470
644801003386	mce related protein; Region: MCE; pfam02470
644801003387	mce related protein; Region: MCE; pfam02470
644801003388	mce related protein; Region: MCE; pfam02470
644801003389	mce related protein; Region: MCE; pfam02470
644801003390	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
644801003391	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
644801003392	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
644801003393	dimer interface [polypeptide binding]; other site
644801003394	active site
644801003395	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
644801003396	catalytic residues [active]
644801003397	substrate binding site [chemical binding]; other site
644801003398	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
644801003399	2-isopropylmalate synthase; Validated; Region: PRK00915
644801003400	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
644801003401	active site
644801003402	catalytic residues [active]
644801003403	metal binding site [ion binding]; metal-binding site
644801003404	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
644801003405	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
644801003406	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801003407	Coenzyme A binding pocket [chemical binding]; other site
644801003408	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
644801003409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801003410	active site
644801003411	motif I; other site
644801003412	motif II; other site
644801003413	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
644801003414	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
644801003415	active site
644801003416	homotetramer interface [polypeptide binding]; other site
644801003417	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
644801003418	active site clefts [active]
644801003419	zinc binding site [ion binding]; other site
644801003420	dimer interface [polypeptide binding]; other site
644801003421	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
644801003422	EamA-like transporter family; Region: EamA; pfam00892
644801003423	outer membrane porin, OprD family; Region: OprD; pfam03573
644801003424	Tannase and feruloyl esterase; Region: Tannase; pfam07519
644801003425	Predicted membrane protein [Function unknown]; Region: COG2259
644801003426	PAS fold; Region: PAS_4; pfam08448
644801003427	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
644801003428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801003429	Walker A motif; other site
644801003430	ATP binding site [chemical binding]; other site
644801003431	Walker B motif; other site
644801003432	arginine finger; other site
644801003433	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801003434	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
644801003435	DctM-like transporters; Region: DctM; pfam06808
644801003436	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
644801003437	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801003438	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
644801003439	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
644801003440	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
644801003441	DNA binding residues [nucleotide binding]
644801003442	putative dimer interface [polypeptide binding]; other site
644801003443	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
644801003444	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
644801003445	dimer interface [polypeptide binding]; other site
644801003446	active site
644801003447	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
644801003448	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
644801003449	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
644801003450	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
644801003451	active site
644801003452	catalytic residues [active]
644801003453	metal binding site [ion binding]; metal-binding site
644801003454	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
644801003455	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
644801003456	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
644801003457	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
644801003458	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
644801003459	carboxyltransferase (CT) interaction site; other site
644801003460	biotinylation site [posttranslational modification]; other site
644801003461	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
644801003462	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801003463	substrate binding site [chemical binding]; other site
644801003464	oxyanion hole (OAH) forming residues; other site
644801003465	trimer interface [polypeptide binding]; other site
644801003466	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
644801003467	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
644801003468	isovaleryl-CoA dehydrogenase; Region: PLN02519
644801003469	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
644801003470	substrate binding site [chemical binding]; other site
644801003471	FAD binding site [chemical binding]; other site
644801003472	catalytic base [active]
644801003473	UV-endonuclease UvdE; Region: UvdE; cl10036
644801003474	AMP-binding domain protein; Validated; Region: PRK08315
644801003475	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
644801003476	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
644801003477	acyl-activating enzyme (AAE) consensus motif; other site
644801003478	putative AMP binding site [chemical binding]; other site
644801003479	putative active site [active]
644801003480	putative CoA binding site [chemical binding]; other site
644801003481	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
644801003482	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
644801003483	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
644801003484	outer membrane porin, OprD family; Region: OprD; pfam03573
644801003485	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
644801003486	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
644801003487	Walker A/P-loop; other site
644801003488	ATP binding site [chemical binding]; other site
644801003489	Q-loop/lid; other site
644801003490	ABC transporter signature motif; other site
644801003491	Walker B; other site
644801003492	D-loop; other site
644801003493	H-loop/switch region; other site
644801003494	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
644801003495	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
644801003496	Walker A/P-loop; other site
644801003497	ATP binding site [chemical binding]; other site
644801003498	Q-loop/lid; other site
644801003499	ABC transporter signature motif; other site
644801003500	Walker B; other site
644801003501	D-loop; other site
644801003502	H-loop/switch region; other site
644801003503	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
644801003504	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
644801003505	putative ligand binding site [chemical binding]; other site
644801003506	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
644801003507	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801003508	TM-ABC transporter signature motif; other site
644801003509	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
644801003510	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801003511	TM-ABC transporter signature motif; other site
644801003512	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
644801003513	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801003514	active site
644801003515	catalytic residues [active]
644801003516	DNA binding site [nucleotide binding]
644801003517	Int/Topo IB signature motif; other site
644801003518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801003519	AAA domain; Region: AAA_21; pfam13304
644801003520	Walker A/P-loop; other site
644801003521	ATP binding site [chemical binding]; other site
644801003522	AAA domain; Region: AAA_21; pfam13304
644801003523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801003524	ABC transporter signature motif; other site
644801003525	Walker B; other site
644801003526	D-loop; other site
644801003527	H-loop/switch region; other site
644801003528	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
644801003529	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
644801003530	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
644801003531	HsdM N-terminal domain; Region: HsdM_N; pfam12161
644801003532	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
644801003533	Methyltransferase domain; Region: Methyltransf_26; pfam13659
644801003534	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
644801003535	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
644801003536	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801003537	ATP binding site [chemical binding]; other site
644801003538	putative Mg++ binding site [ion binding]; other site
644801003539	Fic family protein [Function unknown]; Region: COG3177
644801003540	Fic/DOC family; Region: Fic; pfam02661
644801003541	integrase; Provisional; Region: PRK09692
644801003542	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
644801003543	active site
644801003544	Int/Topo IB signature motif; other site
644801003545	GTP-binding protein YchF; Reviewed; Region: PRK09601
644801003546	YchF GTPase; Region: YchF; cd01900
644801003547	G1 box; other site
644801003548	GTP/Mg2+ binding site [chemical binding]; other site
644801003549	Switch I region; other site
644801003550	G2 box; other site
644801003551	Switch II region; other site
644801003552	G3 box; other site
644801003553	G4 box; other site
644801003554	G5 box; other site
644801003555	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
644801003556	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
644801003557	putative active site [active]
644801003558	catalytic residue [active]
644801003559	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
644801003560	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
644801003561	5S rRNA interface [nucleotide binding]; other site
644801003562	CTC domain interface [polypeptide binding]; other site
644801003563	L16 interface [polypeptide binding]; other site
644801003564	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
644801003565	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
644801003566	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801003567	active site
644801003568	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
644801003569	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
644801003570	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
644801003571	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
644801003572	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
644801003573	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801003574	TPR motif; other site
644801003575	binding surface
644801003576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801003577	binding surface
644801003578	TPR motif; other site
644801003579	TPR repeat; Region: TPR_11; pfam13414
644801003580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801003581	binding surface
644801003582	TPR motif; other site
644801003583	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
644801003584	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
644801003585	tRNA; other site
644801003586	putative tRNA binding site [nucleotide binding]; other site
644801003587	putative NADP binding site [chemical binding]; other site
644801003588	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
644801003589	peptide chain release factor 1; Validated; Region: prfA; PRK00591
644801003590	This domain is found in peptide chain release factors; Region: PCRF; smart00937
644801003591	RF-1 domain; Region: RF-1; pfam00472
644801003592	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
644801003593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801003594	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
644801003595	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
644801003596	ATP binding site [chemical binding]; other site
644801003597	substrate interface [chemical binding]; other site
644801003598	glutamate racemase; Provisional; Region: PRK00865
644801003599	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
644801003600	Flagellin N-methylase; Region: FliB; pfam03692
644801003601	uracil-xanthine permease; Region: ncs2; TIGR00801
644801003602	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801003603	active site
644801003604	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801003605	active site
644801003606	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
644801003607	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
644801003608	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
644801003609	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801003610	DNA binding residues [nucleotide binding]
644801003611	dimerization interface [polypeptide binding]; other site
644801003612	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
644801003613	YebG protein; Region: YebG; cl01217
644801003614	Protein of unknown function (DUF721); Region: DUF721; pfam05258
644801003615	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
644801003616	DEAD/DEAH box helicase; Region: DEAD; pfam00270
644801003617	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
644801003618	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
644801003619	nucleotide binding region [chemical binding]; other site
644801003620	ATP-binding site [chemical binding]; other site
644801003621	SEC-C motif; Region: SEC-C; pfam02810
644801003622	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
644801003623	heterotetramer interface [polypeptide binding]; other site
644801003624	active site pocket [active]
644801003625	cleavage site
644801003626	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
644801003627	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801003628	putative C-terminal domain interface [polypeptide binding]; other site
644801003629	putative GSH binding site (G-site) [chemical binding]; other site
644801003630	putative dimer interface [polypeptide binding]; other site
644801003631	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
644801003632	putative N-terminal domain interface [polypeptide binding]; other site
644801003633	putative dimer interface [polypeptide binding]; other site
644801003634	putative substrate binding pocket (H-site) [chemical binding]; other site
644801003635	hypothetical protein; Provisional; Region: PRK08999
644801003636	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
644801003637	active site
644801003638	8-oxo-dGMP binding site [chemical binding]; other site
644801003639	nudix motif; other site
644801003640	metal binding site [ion binding]; metal-binding site
644801003641	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
644801003642	thiamine phosphate binding site [chemical binding]; other site
644801003643	active site
644801003644	pyrophosphate binding site [ion binding]; other site
644801003645	peroxiredoxin; Region: AhpC; TIGR03137
644801003646	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
644801003647	dimer interface [polypeptide binding]; other site
644801003648	decamer (pentamer of dimers) interface [polypeptide binding]; other site
644801003649	catalytic triad [active]
644801003650	peroxidatic and resolving cysteines [active]
644801003651	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
644801003652	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
644801003653	catalytic residue [active]
644801003654	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
644801003655	catalytic residues [active]
644801003656	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801003657	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801003658	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
644801003659	ATP-grasp domain; Region: ATP-grasp_4; cl17255
644801003660	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
644801003661	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
644801003662	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
644801003663	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
644801003664	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801003665	dimerization interface [polypeptide binding]; other site
644801003666	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
644801003667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801003668	putative active site [active]
644801003669	heme pocket [chemical binding]; other site
644801003670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801003671	dimer interface [polypeptide binding]; other site
644801003672	phosphorylation site [posttranslational modification]
644801003673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801003674	ATP binding site [chemical binding]; other site
644801003675	Mg2+ binding site [ion binding]; other site
644801003676	G-X-G motif; other site
644801003677	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
644801003678	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
644801003679	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
644801003680	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
644801003681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801003682	active site
644801003683	phosphorylation site [posttranslational modification]
644801003684	intermolecular recognition site; other site
644801003685	dimerization interface [polypeptide binding]; other site
644801003686	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801003687	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801003688	metal binding site [ion binding]; metal-binding site
644801003689	active site
644801003690	I-site; other site
644801003691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
644801003692	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
644801003693	mechanosensitive channel MscS; Provisional; Region: PRK10334
644801003694	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801003695	muropeptide transporter; Validated; Region: ampG; cl17669
644801003696	muropeptide transporter; Validated; Region: ampG; cl17669
644801003697	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
644801003698	DNA binding site [nucleotide binding]
644801003699	active site
644801003700	Protein of unknown function, DUF481; Region: DUF481; pfam04338
644801003701	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
644801003702	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801003703	NAD(P) binding site [chemical binding]; other site
644801003704	active site
644801003705	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
644801003706	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
644801003707	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
644801003708	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
644801003709	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
644801003710	oligomerisation interface [polypeptide binding]; other site
644801003711	mobile loop; other site
644801003712	roof hairpin; other site
644801003713	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
644801003714	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
644801003715	ring oligomerisation interface [polypeptide binding]; other site
644801003716	ATP/Mg binding site [chemical binding]; other site
644801003717	stacking interactions; other site
644801003718	hinge regions; other site
644801003719	multidrug efflux protein; Reviewed; Region: PRK09579
644801003720	Protein export membrane protein; Region: SecD_SecF; cl14618
644801003721	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
644801003722	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801003723	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801003724	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801003725	dimerization interface [polypeptide binding]; other site
644801003726	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801003727	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801003728	dimer interface [polypeptide binding]; other site
644801003729	putative CheW interface [polypeptide binding]; other site
644801003730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
644801003731	Imelysin; Region: Peptidase_M75; cl09159
644801003732	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
644801003733	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
644801003734	Imelysin; Region: Peptidase_M75; cl09159
644801003735	LemA family; Region: LemA; cl00742
644801003736	E3 Ubiquitin ligase; Region: GIDE; pfam12483
644801003737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
644801003738	biofilm formation regulator HmsP; Provisional; Region: PRK11829
644801003739	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801003740	metal binding site [ion binding]; metal-binding site
644801003741	active site
644801003742	I-site; other site
644801003743	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801003744	superoxide dismutase; Provisional; Region: PRK10543
644801003745	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
644801003746	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
644801003747	Lysine efflux permease [General function prediction only]; Region: COG1279
644801003748	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
644801003749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801003750	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801003751	dimerization interface [polypeptide binding]; other site
644801003752	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
644801003753	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
644801003754	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
644801003755	active site
644801003756	catalytic triad [active]
644801003757	oxyanion hole [active]
644801003758	Autotransporter beta-domain; Region: Autotransporter; smart00869
644801003759	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801003760	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801003761	metal binding site [ion binding]; metal-binding site
644801003762	active site
644801003763	I-site; other site
644801003764	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
644801003765	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
644801003766	active site
644801003767	General stress protein [General function prediction only]; Region: GsiB; COG3729
644801003768	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
644801003769	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
644801003770	heme-binding site [chemical binding]; other site
644801003771	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
644801003772	FAD binding pocket [chemical binding]; other site
644801003773	FAD binding motif [chemical binding]; other site
644801003774	phosphate binding motif [ion binding]; other site
644801003775	beta-alpha-beta structure motif; other site
644801003776	NAD binding pocket [chemical binding]; other site
644801003777	Heme binding  pocket [chemical binding]; other site
644801003778	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
644801003779	Urea transporter; Region: UT; pfam03253
644801003780	pyruvate kinase; Provisional; Region: PRK06247
644801003781	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
644801003782	domain interfaces; other site
644801003783	active site
644801003784	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
644801003785	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
644801003786	MOFRL family; Region: MOFRL; pfam05161
644801003787	tartronate semialdehyde reductase; Provisional; Region: PRK15059
644801003788	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
644801003789	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
644801003790	glyoxylate carboligase; Provisional; Region: PRK11269
644801003791	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
644801003792	PYR/PP interface [polypeptide binding]; other site
644801003793	dimer interface [polypeptide binding]; other site
644801003794	TPP binding site [chemical binding]; other site
644801003795	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
644801003796	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
644801003797	TPP-binding site [chemical binding]; other site
644801003798	transcriptional activator TtdR; Provisional; Region: PRK09801
644801003799	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801003800	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801003801	putative effector binding pocket; other site
644801003802	dimerization interface [polypeptide binding]; other site
644801003803	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
644801003804	active site
644801003805	homotetramer interface [polypeptide binding]; other site
644801003806	Domain of unknown function (DUF336); Region: DUF336; pfam03928
644801003807	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
644801003808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801003809	active site
644801003810	phosphorylation site [posttranslational modification]
644801003811	intermolecular recognition site; other site
644801003812	dimerization interface [polypeptide binding]; other site
644801003813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801003814	DNA binding site [nucleotide binding]
644801003815	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
644801003816	HAMP domain; Region: HAMP; pfam00672
644801003817	dimerization interface [polypeptide binding]; other site
644801003818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801003819	dimer interface [polypeptide binding]; other site
644801003820	phosphorylation site [posttranslational modification]
644801003821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801003822	ATP binding site [chemical binding]; other site
644801003823	G-X-G motif; other site
644801003824	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
644801003825	putative catalytic site [active]
644801003826	putative phosphate binding site [ion binding]; other site
644801003827	active site
644801003828	metal binding site A [ion binding]; metal-binding site
644801003829	DNA binding site [nucleotide binding]
644801003830	putative AP binding site [nucleotide binding]; other site
644801003831	putative metal binding site B [ion binding]; other site
644801003832	GAF domain; Region: GAF; cl17456
644801003833	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801003834	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
644801003835	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
644801003836	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801003837	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
644801003838	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
644801003839	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
644801003840	xanthine permease; Region: pbuX; TIGR03173
644801003841	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
644801003842	TrkA-N domain; Region: TrkA_N; pfam02254
644801003843	xanthine permease; Region: pbuX; TIGR03173
644801003844	Predicted membrane protein [Function unknown]; Region: COG3748
644801003845	Protein of unknown function (DUF989); Region: DUF989; pfam06181
644801003846	Cytochrome c; Region: Cytochrom_C; pfam00034
644801003847	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
644801003848	ureidoglycolate hydrolase; Provisional; Region: PRK03606
644801003849	allantoicase; Provisional; Region: PRK13257
644801003850	Allantoicase repeat; Region: Allantoicase; pfam03561
644801003851	Allantoicase repeat; Region: Allantoicase; pfam03561
644801003852	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
644801003853	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
644801003854	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
644801003855	active site
644801003856	catalytic site [active]
644801003857	tetramer interface [polypeptide binding]; other site
644801003858	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
644801003859	active site
644801003860	homotetramer interface [polypeptide binding]; other site
644801003861	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
644801003862	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
644801003863	Sulfate transporter family; Region: Sulfate_transp; pfam00916
644801003864	Transcriptional regulators [Transcription]; Region: GntR; COG1802
644801003865	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801003866	DNA-binding site [nucleotide binding]; DNA binding site
644801003867	FCD domain; Region: FCD; pfam07729
644801003868	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801003869	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
644801003870	Walker A/P-loop; other site
644801003871	ATP binding site [chemical binding]; other site
644801003872	Q-loop/lid; other site
644801003873	ABC transporter signature motif; other site
644801003874	Walker B; other site
644801003875	D-loop; other site
644801003876	H-loop/switch region; other site
644801003877	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
644801003878	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
644801003879	ABC-ATPase subunit  interface; other site
644801003880	dimer interface [polypeptide binding]; other site
644801003881	putative PBP binding regions; other site
644801003882	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
644801003883	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
644801003884	metal binding site [ion binding]; metal-binding site
644801003885	guanine deaminase; Provisional; Region: PRK09228
644801003886	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
644801003887	active site
644801003888	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
644801003889	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
644801003890	XdhC Rossmann domain; Region: XdhC_C; pfam13478
644801003891	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
644801003892	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
644801003893	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
644801003894	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
644801003895	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801003896	catalytic loop [active]
644801003897	iron binding site [ion binding]; other site
644801003898	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
644801003899	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
644801003900	oxidase reductase; Provisional; Region: PTZ00273
644801003901	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
644801003902	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
644801003903	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
644801003904	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
644801003905	putative ligand binding site [chemical binding]; other site
644801003906	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
644801003907	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
644801003908	active site
644801003909	putative substrate binding pocket [chemical binding]; other site
644801003910	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
644801003911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801003912	NAD(P) binding site [chemical binding]; other site
644801003913	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
644801003914	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
644801003915	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801003916	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
644801003917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801003918	motif II; other site
644801003919	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
644801003920	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
644801003921	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801003922	substrate binding pocket [chemical binding]; other site
644801003923	membrane-bound complex binding site; other site
644801003924	hinge residues; other site
644801003925	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801003926	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801003927	catalytic residue [active]
644801003928	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
644801003929	GIY-YIG motif/motif A; other site
644801003930	putative active site [active]
644801003931	putative metal binding site [ion binding]; other site
644801003932	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801003933	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
644801003934	C-terminal domain interface [polypeptide binding]; other site
644801003935	GSH binding site (G-site) [chemical binding]; other site
644801003936	dimer interface [polypeptide binding]; other site
644801003937	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
644801003938	substrate binding pocket (H-site) [chemical binding]; other site
644801003939	N-terminal domain interface [polypeptide binding]; other site
644801003940	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
644801003941	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
644801003942	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
644801003943	Nucleoid-associated protein [General function prediction only]; Region: COG3081
644801003944	nucleoid-associated protein NdpA; Validated; Region: PRK00378
644801003945	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
644801003946	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
644801003947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801003948	S-adenosylmethionine binding site [chemical binding]; other site
644801003949	Major Facilitator Superfamily; Region: MFS_1; pfam07690
644801003950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801003951	putative substrate translocation pore; other site
644801003952	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
644801003953	transmembrane helices; other site
644801003954	TrkA-C domain; Region: TrkA_C; pfam02080
644801003955	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
644801003956	TrkA-C domain; Region: TrkA_C; pfam02080
644801003957	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
644801003958	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
644801003959	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
644801003960	NHAD transporter family protein; Provisional; Region: PLN00137
644801003961	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
644801003962	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
644801003963	HIGH motif; other site
644801003964	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
644801003965	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
644801003966	active site
644801003967	KMSKS motif; other site
644801003968	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
644801003969	tRNA binding surface [nucleotide binding]; other site
644801003970	anticodon binding site; other site
644801003971	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
644801003972	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
644801003973	multifunctional aminopeptidase A; Provisional; Region: PRK00913
644801003974	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
644801003975	interface (dimer of trimers) [polypeptide binding]; other site
644801003976	Substrate-binding/catalytic site; other site
644801003977	Zn-binding sites [ion binding]; other site
644801003978	Predicted permeases [General function prediction only]; Region: COG0795
644801003979	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
644801003980	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
644801003981	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
644801003982	RDD family; Region: RDD; pfam06271
644801003983	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801003984	DNA-binding site [nucleotide binding]; DNA binding site
644801003985	RNA-binding motif; other site
644801003986	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
644801003987	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
644801003988	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
644801003989	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
644801003990	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
644801003991	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
644801003992	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
644801003993	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
644801003994	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
644801003995	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
644801003996	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
644801003997	Protein export membrane protein; Region: SecD_SecF; pfam02355
644801003998	hypothetical protein; Provisional; Region: PRK11280
644801003999	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
644801004000	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
644801004001	active site
644801004002	dimerization interface [polypeptide binding]; other site
644801004003	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
644801004004	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
644801004005	serine O-acetyltransferase; Region: cysE; TIGR01172
644801004006	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
644801004007	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
644801004008	trimer interface [polypeptide binding]; other site
644801004009	active site
644801004010	substrate binding site [chemical binding]; other site
644801004011	CoA binding site [chemical binding]; other site
644801004012	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
644801004013	Rrf2 family protein; Region: rrf2_super; TIGR00738
644801004014	cysteine desulfurase; Provisional; Region: PRK14012
644801004015	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
644801004016	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801004017	catalytic residue [active]
644801004018	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
644801004019	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
644801004020	trimerization site [polypeptide binding]; other site
644801004021	active site
644801004022	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
644801004023	co-chaperone HscB; Provisional; Region: hscB; PRK00294
644801004024	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
644801004025	HSP70 interaction site [polypeptide binding]; other site
644801004026	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
644801004027	chaperone protein HscA; Provisional; Region: hscA; PRK05183
644801004028	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
644801004029	nucleotide binding site [chemical binding]; other site
644801004030	putative NEF/HSP70 interaction site [polypeptide binding]; other site
644801004031	SBD interface [polypeptide binding]; other site
644801004032	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
644801004033	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801004034	catalytic loop [active]
644801004035	iron binding site [ion binding]; other site
644801004036	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
644801004037	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
644801004038	active site
644801004039	multimer interface [polypeptide binding]; other site
644801004040	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
644801004041	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801004042	FeS/SAM binding site; other site
644801004043	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
644801004044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801004045	binding surface
644801004046	TPR motif; other site
644801004047	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801004048	binding surface
644801004049	TPR motif; other site
644801004050	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
644801004051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801004052	non-specific DNA binding site [nucleotide binding]; other site
644801004053	salt bridge; other site
644801004054	sequence-specific DNA binding site [nucleotide binding]; other site
644801004055	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
644801004056	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
644801004057	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
644801004058	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
644801004059	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
644801004060	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
644801004061	dimer interface [polypeptide binding]; other site
644801004062	motif 1; other site
644801004063	active site
644801004064	motif 2; other site
644801004065	motif 3; other site
644801004066	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
644801004067	anticodon binding site; other site
644801004068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
644801004069	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
644801004070	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
644801004071	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
644801004072	Trp docking motif [polypeptide binding]; other site
644801004073	active site
644801004074	GTP-binding protein Der; Reviewed; Region: PRK00093
644801004075	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
644801004076	G1 box; other site
644801004077	GTP/Mg2+ binding site [chemical binding]; other site
644801004078	Switch I region; other site
644801004079	G2 box; other site
644801004080	Switch II region; other site
644801004081	G3 box; other site
644801004082	G4 box; other site
644801004083	G5 box; other site
644801004084	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
644801004085	G1 box; other site
644801004086	GTP/Mg2+ binding site [chemical binding]; other site
644801004087	Switch I region; other site
644801004088	G2 box; other site
644801004089	G3 box; other site
644801004090	Switch II region; other site
644801004091	G4 box; other site
644801004092	G5 box; other site
644801004093	serine acetyltransferase; Provisional; Region: cysE; PRK11132
644801004094	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
644801004095	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
644801004096	trimer interface [polypeptide binding]; other site
644801004097	active site
644801004098	substrate binding site [chemical binding]; other site
644801004099	CoA binding site [chemical binding]; other site
644801004100	methionine aminotransferase; Validated; Region: PRK09082
644801004101	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801004102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801004103	homodimer interface [polypeptide binding]; other site
644801004104	catalytic residue [active]
644801004105	C-N hydrolase family amidase; Provisional; Region: PRK10438
644801004106	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
644801004107	putative active site [active]
644801004108	catalytic triad [active]
644801004109	dimer interface [polypeptide binding]; other site
644801004110	multimer interface [polypeptide binding]; other site
644801004111	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
644801004112	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
644801004113	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
644801004114	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
644801004115	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
644801004116	EamA-like transporter family; Region: EamA; pfam00892
644801004117	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
644801004118	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
644801004119	putative NAD(P) binding site [chemical binding]; other site
644801004120	putative substrate binding site [chemical binding]; other site
644801004121	catalytic Zn binding site [ion binding]; other site
644801004122	structural Zn binding site [ion binding]; other site
644801004123	dimer interface [polypeptide binding]; other site
644801004124	2-isopropylmalate synthase; Validated; Region: PRK03739
644801004125	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
644801004126	active site
644801004127	catalytic residues [active]
644801004128	metal binding site [ion binding]; metal-binding site
644801004129	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
644801004130	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801004131	N-terminal plug; other site
644801004132	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
644801004133	ligand-binding site [chemical binding]; other site
644801004134	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
644801004135	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801004136	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
644801004137	Isochorismatase family; Region: Isochorismatase; pfam00857
644801004138	catalytic triad [active]
644801004139	dimer interface [polypeptide binding]; other site
644801004140	conserved cis-peptide bond; other site
644801004141	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
644801004142	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801004143	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
644801004144	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
644801004145	generic binding surface II; other site
644801004146	generic binding surface I; other site
644801004147	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
644801004148	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
644801004149	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
644801004150	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
644801004151	active site
644801004152	GMP synthase; Reviewed; Region: guaA; PRK00074
644801004153	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
644801004154	AMP/PPi binding site [chemical binding]; other site
644801004155	candidate oxyanion hole; other site
644801004156	catalytic triad [active]
644801004157	potential glutamine specificity residues [chemical binding]; other site
644801004158	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
644801004159	ATP Binding subdomain [chemical binding]; other site
644801004160	Ligand Binding sites [chemical binding]; other site
644801004161	Dimerization subdomain; other site
644801004162	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
644801004163	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
644801004164	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
644801004165	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
644801004166	nucleoside/Zn binding site; other site
644801004167	dimer interface [polypeptide binding]; other site
644801004168	catalytic motif [active]
644801004169	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
644801004170	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
644801004171	Walker A/P-loop; other site
644801004172	ATP binding site [chemical binding]; other site
644801004173	Q-loop/lid; other site
644801004174	ABC transporter signature motif; other site
644801004175	Walker B; other site
644801004176	D-loop; other site
644801004177	H-loop/switch region; other site
644801004178	TOBE domain; Region: TOBE_2; pfam08402
644801004179	ornithine carbamoyltransferase; Provisional; Region: PRK00779
644801004180	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
644801004181	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
644801004182	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
644801004183	putative GSH binding site [chemical binding]; other site
644801004184	catalytic residues [active]
644801004185	VanZ like family; Region: VanZ; cl01971
644801004186	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
644801004187	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801004188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801004189	homodimer interface [polypeptide binding]; other site
644801004190	catalytic residue [active]
644801004191	excinuclease ABC subunit B; Provisional; Region: PRK05298
644801004192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801004193	ATP binding site [chemical binding]; other site
644801004194	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801004195	nucleotide binding region [chemical binding]; other site
644801004196	ATP-binding site [chemical binding]; other site
644801004197	Ultra-violet resistance protein B; Region: UvrB; pfam12344
644801004198	UvrB/uvrC motif; Region: UVR; pfam02151
644801004199	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
644801004200	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
644801004201	HIGH motif; other site
644801004202	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
644801004203	active site
644801004204	KMSKS motif; other site
644801004205	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
644801004206	active site
644801004207	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
644801004208	active site
644801004209	DNA polymerase IV; Validated; Region: PRK02406
644801004210	DNA binding site [nucleotide binding]
644801004211	META domain; Region: META; pfam03724
644801004212	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
644801004213	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
644801004214	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
644801004215	Walker A/P-loop; other site
644801004216	ATP binding site [chemical binding]; other site
644801004217	Q-loop/lid; other site
644801004218	ABC transporter signature motif; other site
644801004219	Walker B; other site
644801004220	D-loop; other site
644801004221	H-loop/switch region; other site
644801004222	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
644801004223	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
644801004224	Walker A/P-loop; other site
644801004225	ATP binding site [chemical binding]; other site
644801004226	Q-loop/lid; other site
644801004227	ABC transporter signature motif; other site
644801004228	Walker B; other site
644801004229	D-loop; other site
644801004230	H-loop/switch region; other site
644801004231	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
644801004232	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
644801004233	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
644801004234	TM-ABC transporter signature motif; other site
644801004235	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801004236	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
644801004237	TM-ABC transporter signature motif; other site
644801004238	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
644801004239	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
644801004240	dimerization interface [polypeptide binding]; other site
644801004241	ligand binding site [chemical binding]; other site
644801004242	Protein of unknown function (DUF2288); Region: DUF2288; cl02399
644801004243	Peptidase family M48; Region: Peptidase_M48; cl12018
644801004244	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
644801004245	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
644801004246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
644801004247	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
644801004248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801004249	dimer interface [polypeptide binding]; other site
644801004250	conserved gate region; other site
644801004251	putative PBP binding loops; other site
644801004252	ABC-ATPase subunit interface; other site
644801004253	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
644801004254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801004255	Walker A/P-loop; other site
644801004256	ATP binding site [chemical binding]; other site
644801004257	Q-loop/lid; other site
644801004258	ABC transporter signature motif; other site
644801004259	Walker B; other site
644801004260	D-loop; other site
644801004261	H-loop/switch region; other site
644801004262	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
644801004263	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801004264	substrate binding pocket [chemical binding]; other site
644801004265	membrane-bound complex binding site; other site
644801004266	hinge residues; other site
644801004267	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
644801004268	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
644801004269	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
644801004270	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
644801004271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801004272	putative substrate translocation pore; other site
644801004273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
644801004274	putative chaperone; Provisional; Region: PRK11678
644801004275	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
644801004276	nucleotide binding site [chemical binding]; other site
644801004277	putative NEF/HSP70 interaction site [polypeptide binding]; other site
644801004278	SBD interface [polypeptide binding]; other site
644801004279	CHAD domain; Region: CHAD; pfam05235
644801004280	ATP-dependent helicase HepA; Validated; Region: PRK04914
644801004281	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801004282	ATP binding site [chemical binding]; other site
644801004283	putative Mg++ binding site [ion binding]; other site
644801004284	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801004285	nucleotide binding region [chemical binding]; other site
644801004286	ATP-binding site [chemical binding]; other site
644801004287	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
644801004288	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
644801004289	carbohydrate binding site [chemical binding]; other site
644801004290	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
644801004291	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
644801004292	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
644801004293	Ca binding site [ion binding]; other site
644801004294	active site
644801004295	catalytic site [active]
644801004296	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
644801004297	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
644801004298	dimer interaction site [polypeptide binding]; other site
644801004299	substrate-binding tunnel; other site
644801004300	active site
644801004301	catalytic site [active]
644801004302	substrate binding site [chemical binding]; other site
644801004303	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
644801004304	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
644801004305	acyl-activating enzyme (AAE) consensus motif; other site
644801004306	putative AMP binding site [chemical binding]; other site
644801004307	putative active site [active]
644801004308	putative CoA binding site [chemical binding]; other site
644801004309	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
644801004310	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
644801004311	acyl-activating enzyme (AAE) consensus motif; other site
644801004312	putative AMP binding site [chemical binding]; other site
644801004313	putative active site [active]
644801004314	putative CoA binding site [chemical binding]; other site
644801004315	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
644801004316	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801004317	dimerization interface [polypeptide binding]; other site
644801004318	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801004319	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801004320	dimer interface [polypeptide binding]; other site
644801004321	putative CheW interface [polypeptide binding]; other site
644801004322	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
644801004323	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801004324	dimerization interface [polypeptide binding]; other site
644801004325	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801004326	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801004327	dimer interface [polypeptide binding]; other site
644801004328	putative CheW interface [polypeptide binding]; other site
644801004329	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
644801004330	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
644801004331	PA/protease or protease-like domain interface [polypeptide binding]; other site
644801004332	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
644801004333	Peptidase family M28; Region: Peptidase_M28; pfam04389
644801004334	active site
644801004335	metal binding site [ion binding]; metal-binding site
644801004336	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
644801004337	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801004338	ATP binding site [chemical binding]; other site
644801004339	putative Mg++ binding site [ion binding]; other site
644801004340	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801004341	nucleotide binding region [chemical binding]; other site
644801004342	ATP-binding site [chemical binding]; other site
644801004343	Helicase associated domain (HA2); Region: HA2; pfam04408
644801004344	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
644801004345	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
644801004346	Predicted permeases [General function prediction only]; Region: RarD; COG2962
644801004347	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
644801004348	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
644801004349	phosphopeptide binding site; other site
644801004350	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
644801004351	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
644801004352	phosphopeptide binding site; other site
644801004353	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
644801004354	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
644801004355	active site
644801004356	ATP binding site [chemical binding]; other site
644801004357	substrate binding site [chemical binding]; other site
644801004358	activation loop (A-loop); other site
644801004359	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
644801004360	Protein phosphatase 2C; Region: PP2C; pfam00481
644801004361	active site
644801004362	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
644801004363	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
644801004364	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
644801004365	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
644801004366	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801004367	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
644801004368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801004369	S-adenosylmethionine binding site [chemical binding]; other site
644801004370	hypothetical protein; Provisional; Region: PRK11171
644801004371	Cupin domain; Region: Cupin_2; pfam07883
644801004372	Cupin domain; Region: Cupin_2; pfam07883
644801004373	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
644801004374	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801004375	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
644801004376	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801004377	Predicted membrane protein [Function unknown]; Region: COG3503
644801004378	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
644801004379	dimer interface [polypeptide binding]; other site
644801004380	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801004381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
644801004382	CAAX protease self-immunity; Region: Abi; pfam02517
644801004383	Predicted periplasmic protein [Function unknown]; Region: COG3904
644801004384	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
644801004385	MOSC domain; Region: MOSC; pfam03473
644801004386	glutamate carboxypeptidase; Reviewed; Region: PRK06133
644801004387	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
644801004388	metal binding site [ion binding]; metal-binding site
644801004389	dimer interface [polypeptide binding]; other site
644801004390	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
644801004391	HIT family signature motif; other site
644801004392	catalytic residue [active]
644801004393	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801004394	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801004395	membrane-bound complex binding site; other site
644801004396	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801004397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801004398	dimer interface [polypeptide binding]; other site
644801004399	conserved gate region; other site
644801004400	putative PBP binding loops; other site
644801004401	ABC-ATPase subunit interface; other site
644801004402	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
644801004403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801004404	Walker A/P-loop; other site
644801004405	ATP binding site [chemical binding]; other site
644801004406	Q-loop/lid; other site
644801004407	ABC transporter signature motif; other site
644801004408	Walker B; other site
644801004409	D-loop; other site
644801004410	H-loop/switch region; other site
644801004411	Protein of unknown function (DUF445); Region: DUF445; pfam04286
644801004412	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
644801004413	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801004414	dimerization interface [polypeptide binding]; other site
644801004415	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801004416	dimer interface [polypeptide binding]; other site
644801004417	putative CheW interface [polypeptide binding]; other site
644801004418	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
644801004419	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
644801004420	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801004421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801004422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801004423	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
644801004424	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
644801004425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801004426	dimerization interface [polypeptide binding]; other site
644801004427	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801004428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801004429	dimer interface [polypeptide binding]; other site
644801004430	putative CheW interface [polypeptide binding]; other site
644801004431	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
644801004432	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
644801004433	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
644801004434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801004435	putative substrate translocation pore; other site
644801004436	Nitrate and nitrite sensing; Region: NIT; pfam08376
644801004437	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801004438	dimerization interface [polypeptide binding]; other site
644801004439	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801004440	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801004441	dimer interface [polypeptide binding]; other site
644801004442	putative CheW interface [polypeptide binding]; other site
644801004443	hypothetical protein; Provisional; Region: PRK09272
644801004444	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
644801004445	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
644801004446	transmembrane helices; other site
644801004447	TrkA-C domain; Region: TrkA_C; pfam02080
644801004448	TrkA-C domain; Region: TrkA_C; pfam02080
644801004449	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
644801004450	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
644801004451	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
644801004452	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
644801004453	DNA topoisomerase III; Provisional; Region: PRK07726
644801004454	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
644801004455	active site
644801004456	putative interdomain interaction site [polypeptide binding]; other site
644801004457	putative metal-binding site [ion binding]; other site
644801004458	putative nucleotide binding site [chemical binding]; other site
644801004459	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
644801004460	domain I; other site
644801004461	DNA binding groove [nucleotide binding]
644801004462	phosphate binding site [ion binding]; other site
644801004463	domain II; other site
644801004464	domain III; other site
644801004465	nucleotide binding site [chemical binding]; other site
644801004466	catalytic site [active]
644801004467	domain IV; other site
644801004468	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
644801004469	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
644801004470	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
644801004471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
644801004472	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801004473	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
644801004474	TM-ABC transporter signature motif; other site
644801004475	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801004476	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
644801004477	TM-ABC transporter signature motif; other site
644801004478	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
644801004479	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
644801004480	Walker A/P-loop; other site
644801004481	ATP binding site [chemical binding]; other site
644801004482	Q-loop/lid; other site
644801004483	ABC transporter signature motif; other site
644801004484	Walker B; other site
644801004485	D-loop; other site
644801004486	H-loop/switch region; other site
644801004487	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
644801004488	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
644801004489	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801004490	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801004491	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
644801004492	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
644801004493	classical (c) SDRs; Region: SDR_c; cd05233
644801004494	NAD(P) binding site [chemical binding]; other site
644801004495	active site
644801004496	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
644801004497	nucleoside/Zn binding site; other site
644801004498	dimer interface [polypeptide binding]; other site
644801004499	catalytic motif [active]
644801004500	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801004501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801004502	putative PBP binding loops; other site
644801004503	dimer interface [polypeptide binding]; other site
644801004504	ABC-ATPase subunit interface; other site
644801004505	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
644801004506	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
644801004507	Walker A/P-loop; other site
644801004508	ATP binding site [chemical binding]; other site
644801004509	Q-loop/lid; other site
644801004510	ABC transporter signature motif; other site
644801004511	Walker B; other site
644801004512	D-loop; other site
644801004513	H-loop/switch region; other site
644801004514	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801004515	NMT1/THI5 like; Region: NMT1; pfam09084
644801004516	substrate binding pocket [chemical binding]; other site
644801004517	membrane-bound complex binding site; other site
644801004518	hinge residues; other site
644801004519	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801004520	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
644801004521	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
644801004522	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
644801004523	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
644801004524	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
644801004525	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801004526	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801004527	putative DNA binding site [nucleotide binding]; other site
644801004528	putative Zn2+ binding site [ion binding]; other site
644801004529	AsnC family; Region: AsnC_trans_reg; pfam01037
644801004530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801004531	S-adenosylmethionine binding site [chemical binding]; other site
644801004532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801004533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801004534	dimer interface [polypeptide binding]; other site
644801004535	phosphorylation site [posttranslational modification]
644801004536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801004537	ATP binding site [chemical binding]; other site
644801004538	G-X-G motif; other site
644801004539	Response regulator receiver domain; Region: Response_reg; pfam00072
644801004540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801004541	active site
644801004542	phosphorylation site [posttranslational modification]
644801004543	intermolecular recognition site; other site
644801004544	dimerization interface [polypeptide binding]; other site
644801004545	circadian clock protein KaiC; Reviewed; Region: PRK09302
644801004546	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
644801004547	Walker A motif; other site
644801004548	ATP binding site [chemical binding]; other site
644801004549	Walker B motif; other site
644801004550	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
644801004551	Walker A motif; other site
644801004552	ATP binding site [chemical binding]; other site
644801004553	Walker B motif; other site
644801004554	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
644801004555	ABC1 family; Region: ABC1; cl17513
644801004556	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
644801004557	active site
644801004558	ATP binding site [chemical binding]; other site
644801004559	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
644801004560	C factor cell-cell signaling protein; Provisional; Region: PRK09009
644801004561	NADP binding site [chemical binding]; other site
644801004562	homodimer interface [polypeptide binding]; other site
644801004563	active site
644801004564	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801004565	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
644801004566	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
644801004567	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
644801004568	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
644801004569	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801004570	Restriction endonuclease; Region: Mrr_cat; pfam04471
644801004571	Transposase domain (DUF772); Region: DUF772; pfam05598
644801004572	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
644801004573	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
644801004574	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801004575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801004576	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
644801004577	putative effector binding pocket; other site
644801004578	putative dimerization interface [polypeptide binding]; other site
644801004579	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801004580	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
644801004581	active site
644801004582	metal binding site [ion binding]; metal-binding site
644801004583	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801004584	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
644801004585	putative C-terminal domain interface [polypeptide binding]; other site
644801004586	putative GSH binding site (G-site) [chemical binding]; other site
644801004587	putative dimer interface [polypeptide binding]; other site
644801004588	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
644801004589	putative N-terminal domain interface [polypeptide binding]; other site
644801004590	putative dimer interface [polypeptide binding]; other site
644801004591	putative substrate binding pocket (H-site) [chemical binding]; other site
644801004592	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
644801004593	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
644801004594	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
644801004595	Trp docking motif [polypeptide binding]; other site
644801004596	cytochrome domain interface [polypeptide binding]; other site
644801004597	active site
644801004598	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
644801004599	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
644801004600	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
644801004601	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801004602	E3 interaction surface; other site
644801004603	lipoyl attachment site [posttranslational modification]; other site
644801004604	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
644801004605	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
644801004606	alpha subunit interface [polypeptide binding]; other site
644801004607	TPP binding site [chemical binding]; other site
644801004608	heterodimer interface [polypeptide binding]; other site
644801004609	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
644801004610	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
644801004611	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
644801004612	putative NAD(P) binding site [chemical binding]; other site
644801004613	catalytic Zn binding site [ion binding]; other site
644801004614	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
644801004615	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
644801004616	tetramer interface [polypeptide binding]; other site
644801004617	TPP-binding site [chemical binding]; other site
644801004618	heterodimer interface [polypeptide binding]; other site
644801004619	phosphorylation loop region [posttranslational modification]
644801004620	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
644801004621	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
644801004622	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
644801004623	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
644801004624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801004625	Walker A motif; other site
644801004626	ATP binding site [chemical binding]; other site
644801004627	Walker B motif; other site
644801004628	arginine finger; other site
644801004629	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801004630	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
644801004631	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
644801004632	putative NAD(P) binding site [chemical binding]; other site
644801004633	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
644801004634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801004635	S-adenosylmethionine binding site [chemical binding]; other site
644801004636	Domain of unknown function (DUF305); Region: DUF305; cl17794
644801004637	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
644801004638	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801004639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801004640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801004641	dimerization interface [polypeptide binding]; other site
644801004642	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
644801004643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801004644	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
644801004645	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
644801004646	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801004647	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801004648	Curlin associated repeat; Region: Curlin_rpt; pfam07012
644801004649	Curlin associated repeat; Region: Curlin_rpt; pfam07012
644801004650	Curlin associated repeat; Region: Curlin_rpt; pfam07012
644801004651	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
644801004652	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
644801004653	curli assembly protein CsgE; Provisional; Region: PRK10386
644801004654	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
644801004655	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801004656	DNA binding residues [nucleotide binding]
644801004657	dimerization interface [polypeptide binding]; other site
644801004658	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
644801004659	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
644801004660	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801004661	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
644801004662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801004663	NAD(P) binding site [chemical binding]; other site
644801004664	active site
644801004665	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
644801004666	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801004667	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
644801004668	putative dimerization interface [polypeptide binding]; other site
644801004669	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
644801004670	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
644801004671	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
644801004672	THF binding site; other site
644801004673	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
644801004674	substrate binding site [chemical binding]; other site
644801004675	THF binding site; other site
644801004676	zinc-binding site [ion binding]; other site
644801004677	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
644801004678	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
644801004679	putative deacylase active site [active]
644801004680	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
644801004681	MASE2 domain; Region: MASE2; pfam05230
644801004682	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801004683	metal binding site [ion binding]; metal-binding site
644801004684	active site
644801004685	I-site; other site
644801004686	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
644801004687	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
644801004688	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
644801004689	Cytochrome c; Region: Cytochrom_C; cl11414
644801004690	Cytochrome c; Region: Cytochrom_C; cl11414
644801004691	Cytochrome c [Energy production and conversion]; Region: COG3258
644801004692	Cytochrome c; Region: Cytochrom_C; pfam00034
644801004693	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
644801004694	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
644801004695	dimer interface [polypeptide binding]; other site
644801004696	active site
644801004697	CoA binding pocket [chemical binding]; other site
644801004698	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
644801004699	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
644801004700	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
644801004701	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801004702	catalytic residue [active]
644801004703	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
644801004704	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
644801004705	putative trimer interface [polypeptide binding]; other site
644801004706	putative CoA binding site [chemical binding]; other site
644801004707	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
644801004708	ArsC family; Region: ArsC; pfam03960
644801004709	putative catalytic residues [active]
644801004710	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
644801004711	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
644801004712	catalytic residues [active]
644801004713	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
644801004714	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801004715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801004716	homodimer interface [polypeptide binding]; other site
644801004717	catalytic residue [active]
644801004718	Predicted membrane protein [Function unknown]; Region: COG3650
644801004719	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
644801004720	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
644801004721	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
644801004722	active site
644801004723	substrate binding site [chemical binding]; other site
644801004724	cosubstrate binding site; other site
644801004725	catalytic site [active]
644801004726	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
644801004727	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
644801004728	dimerization interface [polypeptide binding]; other site
644801004729	putative ATP binding site [chemical binding]; other site
644801004730	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
644801004731	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
644801004732	Domain of unknown function DUF20; Region: UPF0118; pfam01594
644801004733	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
644801004734	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
644801004735	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
644801004736	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
644801004737	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801004738	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
644801004739	ArsC family; Region: ArsC; pfam03960
644801004740	catalytic residues [active]
644801004741	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
644801004742	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
644801004743	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
644801004744	catalytic residues [active]
644801004745	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
644801004746	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801004747	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801004748	catalytic residue [active]
644801004749	prolyl-tRNA synthetase; Provisional; Region: PRK09194
644801004750	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
644801004751	dimer interface [polypeptide binding]; other site
644801004752	motif 1; other site
644801004753	active site
644801004754	motif 2; other site
644801004755	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
644801004756	putative deacylase active site [active]
644801004757	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
644801004758	active site
644801004759	motif 3; other site
644801004760	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
644801004761	anticodon binding site; other site
644801004762	outer membrane porin, OprD family; Region: OprD; pfam03573
644801004763	HIT domain; Region: HIT; pfam01230
644801004764	nucleotide binding site/active site [active]
644801004765	HIT family signature motif; other site
644801004766	catalytic residue [active]
644801004767	hypothetical protein; Provisional; Region: PRK00295
644801004768	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801004769	DNA-binding site [nucleotide binding]; DNA binding site
644801004770	RNA-binding motif; other site
644801004771	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
644801004772	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
644801004773	dimerization interface [polypeptide binding]; other site
644801004774	DPS ferroxidase diiron center [ion binding]; other site
644801004775	ion pore; other site
644801004776	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
644801004777	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
644801004778	dimer interface [polypeptide binding]; other site
644801004779	anticodon binding site; other site
644801004780	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
644801004781	homodimer interface [polypeptide binding]; other site
644801004782	motif 1; other site
644801004783	active site
644801004784	motif 2; other site
644801004785	GAD domain; Region: GAD; pfam02938
644801004786	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
644801004787	active site
644801004788	motif 3; other site
644801004789	hypothetical protein; Validated; Region: PRK00110
644801004790	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
644801004791	active site
644801004792	putative DNA-binding cleft [nucleotide binding]; other site
644801004793	dimer interface [polypeptide binding]; other site
644801004794	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
644801004795	RuvA N terminal domain; Region: RuvA_N; pfam01330
644801004796	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
644801004797	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
644801004798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801004799	Walker A motif; other site
644801004800	ATP binding site [chemical binding]; other site
644801004801	Walker B motif; other site
644801004802	arginine finger; other site
644801004803	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
644801004804	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
644801004805	active site
644801004806	TolQ protein; Region: tolQ; TIGR02796
644801004807	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
644801004808	TolR protein; Region: tolR; TIGR02801
644801004809	TolA protein; Region: tolA_full; TIGR02794
644801004810	TolA protein; Region: tolA_full; TIGR02794
644801004811	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
644801004812	translocation protein TolB; Provisional; Region: tolB; PRK00178
644801004813	TolB amino-terminal domain; Region: TolB_N; pfam04052
644801004814	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
644801004815	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
644801004816	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
644801004817	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801004818	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801004819	ligand binding site [chemical binding]; other site
644801004820	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
644801004821	Tetratricopeptide repeat; Region: TPR_6; pfam13174
644801004822	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
644801004823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801004824	FeS/SAM binding site; other site
644801004825	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
644801004826	Ligand Binding Site [chemical binding]; other site
644801004827	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
644801004828	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
644801004829	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
644801004830	quinolinate synthetase; Provisional; Region: PRK09375
644801004831	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
644801004832	Peptidase family M48; Region: Peptidase_M48; cl12018
644801004833	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
644801004834	CPxP  motif; other site
644801004835	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
644801004836	Domain of unknown function DUF20; Region: UPF0118; pfam01594
644801004837	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
644801004838	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
644801004839	catalytic triad [active]
644801004840	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
644801004841	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
644801004842	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
644801004843	dihydrodipicolinate synthase; Region: dapA; TIGR00674
644801004844	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
644801004845	dimer interface [polypeptide binding]; other site
644801004846	active site
644801004847	catalytic residue [active]
644801004848	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
644801004849	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
644801004850	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
644801004851	ATP binding site [chemical binding]; other site
644801004852	active site
644801004853	substrate binding site [chemical binding]; other site
644801004854	DNA polymerase II; Reviewed; Region: PRK05762
644801004855	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
644801004856	active site
644801004857	catalytic site [active]
644801004858	substrate binding site [chemical binding]; other site
644801004859	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
644801004860	active site
644801004861	metal-binding site
644801004862	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
644801004863	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
644801004864	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
644801004865	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
644801004866	Sel1 repeat; Region: Sel1; cl02723
644801004867	RmuC family; Region: RmuC; pfam02646
644801004868	Predicted membrane protein [Function unknown]; Region: COG3174
644801004869	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
644801004870	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
644801004871	Na binding site [ion binding]; other site
644801004872	PAS domain; Region: PAS; smart00091
644801004873	PAS fold; Region: PAS_7; pfam12860
644801004874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801004875	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801004876	dimer interface [polypeptide binding]; other site
644801004877	phosphorylation site [posttranslational modification]
644801004878	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801004879	ATP binding site [chemical binding]; other site
644801004880	Mg2+ binding site [ion binding]; other site
644801004881	G-X-G motif; other site
644801004882	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801004883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801004884	active site
644801004885	phosphorylation site [posttranslational modification]
644801004886	intermolecular recognition site; other site
644801004887	dimerization interface [polypeptide binding]; other site
644801004888	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
644801004889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
644801004890	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
644801004891	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
644801004892	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
644801004893	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
644801004894	recombination associated protein; Reviewed; Region: rdgC; PRK00321
644801004895	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
644801004896	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
644801004897	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
644801004898	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
644801004899	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
644801004900	heme binding site [chemical binding]; other site
644801004901	ferroxidase pore; other site
644801004902	ferroxidase diiron center [ion binding]; other site
644801004903	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
644801004904	YaeQ protein; Region: YaeQ; pfam07152
644801004905	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
644801004906	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
644801004907	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
644801004908	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
644801004909	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
644801004910	putative active site [active]
644801004911	MarR family; Region: MarR_2; cl17246
644801004912	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
644801004913	DHH family; Region: DHH; pfam01368
644801004914	DHHA1 domain; Region: DHHA1; pfam02272
644801004915	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
644801004916	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
644801004917	putative [Fe4-S4] binding site [ion binding]; other site
644801004918	putative molybdopterin cofactor binding site [chemical binding]; other site
644801004919	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
644801004920	putative molybdopterin cofactor binding site; other site
644801004921	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801004922	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
644801004923	active site
644801004924	FMN binding site [chemical binding]; other site
644801004925	substrate binding site [chemical binding]; other site
644801004926	homotetramer interface [polypeptide binding]; other site
644801004927	catalytic residue [active]
644801004928	Protein of unknown function (DUF533); Region: DUF533; pfam04391
644801004929	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
644801004930	putative metal binding site [ion binding]; other site
644801004931	peptide chain release factor 2; Validated; Region: prfB; PRK00578
644801004932	This domain is found in peptide chain release factors; Region: PCRF; smart00937
644801004933	RF-1 domain; Region: RF-1; pfam00472
644801004934	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
644801004935	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
644801004936	dimer interface [polypeptide binding]; other site
644801004937	putative anticodon binding site; other site
644801004938	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
644801004939	motif 1; other site
644801004940	active site
644801004941	motif 2; other site
644801004942	motif 3; other site
644801004943	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
644801004944	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
644801004945	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801004946	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801004947	ligand binding site [chemical binding]; other site
644801004948	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
644801004949	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
644801004950	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
644801004951	adenylate kinase; Reviewed; Region: adk; PRK00279
644801004952	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
644801004953	AMP-binding site [chemical binding]; other site
644801004954	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
644801004955	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
644801004956	Glycoprotease family; Region: Peptidase_M22; pfam00814
644801004957	Protein of unknown function DUF72; Region: DUF72; cl00777
644801004958	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
644801004959	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
644801004960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801004961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801004962	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
644801004963	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
644801004964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801004965	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801004966	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
644801004967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801004968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801004969	PAS domain S-box; Region: sensory_box; TIGR00229
644801004970	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801004971	putative active site [active]
644801004972	heme pocket [chemical binding]; other site
644801004973	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
644801004974	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
644801004975	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801004976	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801004977	metal binding site [ion binding]; metal-binding site
644801004978	active site
644801004979	I-site; other site
644801004980	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
644801004981	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801004982	DNA-binding site [nucleotide binding]; DNA binding site
644801004983	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801004984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801004985	homodimer interface [polypeptide binding]; other site
644801004986	catalytic residue [active]
644801004987	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
644801004988	4Fe-4S binding domain; Region: Fer4_5; pfam12801
644801004989	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
644801004990	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
644801004991	LrgA family; Region: LrgA; cl00608
644801004992	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
644801004993	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
644801004994	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
644801004995	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
644801004996	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
644801004997	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
644801004998	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
644801004999	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
644801005000	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
644801005001	Ligand binding site; other site
644801005002	DXD motif; other site
644801005003	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
644801005004	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
644801005005	Pirin-related protein [General function prediction only]; Region: COG1741
644801005006	Pirin; Region: Pirin; pfam02678
644801005007	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
644801005008	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801005009	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
644801005010	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801005011	Coenzyme A binding pocket [chemical binding]; other site
644801005012	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
644801005013	outer membrane porin, OprD family; Region: OprD; pfam03573
644801005014	citrate-proton symporter; Provisional; Region: PRK15075
644801005015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801005016	putative substrate translocation pore; other site
644801005017	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
644801005018	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
644801005019	metal binding site [ion binding]; metal-binding site
644801005020	putative dimer interface [polypeptide binding]; other site
644801005021	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
644801005022	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801005023	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801005024	dimerization interface [polypeptide binding]; other site
644801005025	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801005026	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
644801005027	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
644801005028	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
644801005029	Multicopper oxidase; Region: Cu-oxidase; pfam00394
644801005030	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
644801005031	hypothetical protein; Provisional; Region: PRK09272
644801005032	Predicted metal-binding protein [General function prediction only]; Region: COG3019
644801005033	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801005034	metal-binding site [ion binding]
644801005035	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801005036	metal-binding site [ion binding]
644801005037	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
644801005038	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801005039	metal-binding site [ion binding]
644801005040	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801005041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801005042	motif II; other site
644801005043	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
644801005044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005045	active site
644801005046	phosphorylation site [posttranslational modification]
644801005047	intermolecular recognition site; other site
644801005048	dimerization interface [polypeptide binding]; other site
644801005049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801005050	DNA binding site [nucleotide binding]
644801005051	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
644801005052	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801005053	dimerization interface [polypeptide binding]; other site
644801005054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801005055	dimer interface [polypeptide binding]; other site
644801005056	phosphorylation site [posttranslational modification]
644801005057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005058	ATP binding site [chemical binding]; other site
644801005059	G-X-G motif; other site
644801005060	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
644801005061	sensor protein QseC; Provisional; Region: PRK10337
644801005062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801005063	dimer interface [polypeptide binding]; other site
644801005064	phosphorylation site [posttranslational modification]
644801005065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005066	ATP binding site [chemical binding]; other site
644801005067	Mg2+ binding site [ion binding]; other site
644801005068	G-X-G motif; other site
644801005069	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
644801005070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005071	active site
644801005072	phosphorylation site [posttranslational modification]
644801005073	intermolecular recognition site; other site
644801005074	dimerization interface [polypeptide binding]; other site
644801005075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801005076	DNA binding site [nucleotide binding]
644801005077	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
644801005078	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
644801005079	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
644801005080	DsbD alpha interface [polypeptide binding]; other site
644801005081	catalytic residues [active]
644801005082	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
644801005083	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
644801005084	catalytic residues [active]
644801005085	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
644801005086	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
644801005087	dimerization domain [polypeptide binding]; other site
644801005088	dimer interface [polypeptide binding]; other site
644801005089	catalytic residues [active]
644801005090	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
644801005091	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
644801005092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801005093	Coenzyme A binding pocket [chemical binding]; other site
644801005094	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
644801005095	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
644801005096	putative acyl-acceptor binding pocket; other site
644801005097	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
644801005098	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
644801005099	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
644801005100	Walker A/P-loop; other site
644801005101	ATP binding site [chemical binding]; other site
644801005102	Q-loop/lid; other site
644801005103	ABC transporter signature motif; other site
644801005104	Walker B; other site
644801005105	D-loop; other site
644801005106	H-loop/switch region; other site
644801005107	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
644801005108	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
644801005109	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
644801005110	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801005111	DNA-binding site [nucleotide binding]; DNA binding site
644801005112	RNA-binding motif; other site
644801005113	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
644801005114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801005115	S-adenosylmethionine binding site [chemical binding]; other site
644801005116	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
644801005117	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
644801005118	metal binding site [ion binding]; metal-binding site
644801005119	dimer interface [polypeptide binding]; other site
644801005120	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
644801005121	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
644801005122	putative ATP binding site [chemical binding]; other site
644801005123	putative substrate interface [chemical binding]; other site
644801005124	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
644801005125	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
644801005126	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
644801005127	Protein of unknown function, DUF482; Region: DUF482; pfam04339
644801005128	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
644801005129	active site
644801005130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801005131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801005132	LysR substrate binding domain; Region: LysR_substrate; pfam03466
644801005133	dimerization interface [polypeptide binding]; other site
644801005134	helicase 45; Provisional; Region: PTZ00424
644801005135	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
644801005136	ATP binding site [chemical binding]; other site
644801005137	Mg++ binding site [ion binding]; other site
644801005138	motif III; other site
644801005139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801005140	nucleotide binding region [chemical binding]; other site
644801005141	ATP-binding site [chemical binding]; other site
644801005142	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801005143	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801005144	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801005145	dimerization interface [polypeptide binding]; other site
644801005146	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
644801005147	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
644801005148	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
644801005149	Uncharacterized conserved protein [Function unknown]; Region: COG4121
644801005150	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
644801005151	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
644801005152	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801005153	dimerization interface [polypeptide binding]; other site
644801005154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801005155	dimer interface [polypeptide binding]; other site
644801005156	phosphorylation site [posttranslational modification]
644801005157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005158	ATP binding site [chemical binding]; other site
644801005159	Mg2+ binding site [ion binding]; other site
644801005160	G-X-G motif; other site
644801005161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005162	active site
644801005163	phosphorylation site [posttranslational modification]
644801005164	intermolecular recognition site; other site
644801005165	dimerization interface [polypeptide binding]; other site
644801005166	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801005167	putative binding surface; other site
644801005168	active site
644801005169	Predicted membrane protein [Function unknown]; Region: COG2860
644801005170	UPF0126 domain; Region: UPF0126; pfam03458
644801005171	UPF0126 domain; Region: UPF0126; pfam03458
644801005172	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
644801005173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801005174	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
644801005175	putative dimerization interface [polypeptide binding]; other site
644801005176	cysteine synthase B; Region: cysM; TIGR01138
644801005177	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
644801005178	dimer interface [polypeptide binding]; other site
644801005179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801005180	catalytic residue [active]
644801005181	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
644801005182	TRAM domain; Region: TRAM; pfam01938
644801005183	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
644801005184	HD domain; Region: HD_4; pfam13328
644801005185	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
644801005186	synthetase active site [active]
644801005187	NTP binding site [chemical binding]; other site
644801005188	metal binding site [ion binding]; metal-binding site
644801005189	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
644801005190	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
644801005191	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
644801005192	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
644801005193	homodimer interface [polypeptide binding]; other site
644801005194	metal binding site [ion binding]; metal-binding site
644801005195	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
644801005196	homodimer interface [polypeptide binding]; other site
644801005197	active site
644801005198	putative chemical substrate binding site [chemical binding]; other site
644801005199	metal binding site [ion binding]; metal-binding site
644801005200	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
644801005201	Erythromycin esterase; Region: Erythro_esteras; pfam05139
644801005202	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
644801005203	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
644801005204	putative active site [active]
644801005205	putative metal binding site [ion binding]; other site
644801005206	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
644801005207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801005208	ATP binding site [chemical binding]; other site
644801005209	putative Mg++ binding site [ion binding]; other site
644801005210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801005211	nucleotide binding region [chemical binding]; other site
644801005212	ATP-binding site [chemical binding]; other site
644801005213	DEAD/H associated; Region: DEAD_assoc; pfam08494
644801005214	ATP-dependent DNA ligase; Validated; Region: PRK09247
644801005215	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
644801005216	active site
644801005217	DNA binding site [nucleotide binding]
644801005218	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
644801005219	DNA binding site [nucleotide binding]
644801005220	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
644801005221	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
644801005222	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
644801005223	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
644801005224	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801005225	ATP binding site [chemical binding]; other site
644801005226	putative Mg++ binding site [ion binding]; other site
644801005227	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801005228	nucleotide binding region [chemical binding]; other site
644801005229	ATP-binding site [chemical binding]; other site
644801005230	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
644801005231	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
644801005232	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
644801005233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801005234	ATP binding site [chemical binding]; other site
644801005235	putative Mg++ binding site [ion binding]; other site
644801005236	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801005237	nucleotide binding region [chemical binding]; other site
644801005238	ATP-binding site [chemical binding]; other site
644801005239	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
644801005240	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
644801005241	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
644801005242	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
644801005243	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
644801005244	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
644801005245	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
644801005246	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
644801005247	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
644801005248	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
644801005249	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
644801005250	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
644801005251	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801005252	catalytic loop [active]
644801005253	iron binding site [ion binding]; other site
644801005254	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
644801005255	FAD binding pocket [chemical binding]; other site
644801005256	FAD binding motif [chemical binding]; other site
644801005257	phosphate binding motif [ion binding]; other site
644801005258	beta-alpha-beta structure motif; other site
644801005259	NAD binding pocket [chemical binding]; other site
644801005260	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
644801005261	ApbE family; Region: ApbE; pfam02424
644801005262	Protein of unknown function (DUF539); Region: DUF539; cl01129
644801005263	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
644801005264	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801005265	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801005266	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
644801005267	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
644801005268	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
644801005269	active site
644801005270	catalytic site [active]
644801005271	metal binding site [ion binding]; metal-binding site
644801005272	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
644801005273	PilZ domain; Region: PilZ; pfam07238
644801005274	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
644801005275	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
644801005276	FtsX-like permease family; Region: FtsX; pfam02687
644801005277	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
644801005278	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
644801005279	Walker A/P-loop; other site
644801005280	ATP binding site [chemical binding]; other site
644801005281	Q-loop/lid; other site
644801005282	ABC transporter signature motif; other site
644801005283	Walker B; other site
644801005284	D-loop; other site
644801005285	H-loop/switch region; other site
644801005286	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
644801005287	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
644801005288	FtsX-like permease family; Region: FtsX; pfam02687
644801005289	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
644801005290	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
644801005291	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
644801005292	Competence protein; Region: Competence; pfam03772
644801005293	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
644801005294	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
644801005295	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
644801005296	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
644801005297	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
644801005298	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
644801005299	Uncharacterized conserved protein [Function unknown]; Region: COG2835
644801005300	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
644801005301	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
644801005302	Ligand binding site; other site
644801005303	oligomer interface; other site
644801005304	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
644801005305	Low molecular weight phosphatase family; Region: LMWPc; cd00115
644801005306	active site
644801005307	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
644801005308	FAD binding domain; Region: FAD_binding_4; pfam01565
644801005309	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
644801005310	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
644801005311	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
644801005312	homodimer interface [polypeptide binding]; other site
644801005313	oligonucleotide binding site [chemical binding]; other site
644801005314	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
644801005315	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801005316	RNA binding surface [nucleotide binding]; other site
644801005317	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
644801005318	active site
644801005319	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
644801005320	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801005321	motif II; other site
644801005322	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
644801005323	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
644801005324	tandem repeat interface [polypeptide binding]; other site
644801005325	oligomer interface [polypeptide binding]; other site
644801005326	active site residues [active]
644801005327	Maf-like protein; Region: Maf; pfam02545
644801005328	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
644801005329	active site
644801005330	dimer interface [polypeptide binding]; other site
644801005331	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
644801005332	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
644801005333	putative phosphate acyltransferase; Provisional; Region: PRK05331
644801005334	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
644801005335	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
644801005336	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
644801005337	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
644801005338	NAD(P) binding site [chemical binding]; other site
644801005339	homotetramer interface [polypeptide binding]; other site
644801005340	homodimer interface [polypeptide binding]; other site
644801005341	active site
644801005342	acyl carrier protein; Provisional; Region: acpP; PRK00982
644801005343	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
644801005344	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
644801005345	dimer interface [polypeptide binding]; other site
644801005346	active site
644801005347	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
644801005348	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
644801005349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801005350	catalytic residue [active]
644801005351	YceG-like family; Region: YceG; pfam02618
644801005352	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
644801005353	dimerization interface [polypeptide binding]; other site
644801005354	thymidylate kinase; Validated; Region: tmk; PRK00698
644801005355	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
644801005356	TMP-binding site; other site
644801005357	ATP-binding site [chemical binding]; other site
644801005358	DNA polymerase III subunit delta'; Validated; Region: PRK05707
644801005359	PilZ domain; Region: PilZ; cl01260
644801005360	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
644801005361	active site
644801005362	aromatic amino acid transporter; Provisional; Region: PRK10238
644801005363	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
644801005364	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
644801005365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801005366	catalytic residue [active]
644801005367	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801005368	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801005369	WHG domain; Region: WHG; pfam13305
644801005370	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
644801005371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801005372	FeS/SAM binding site; other site
644801005373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
644801005374	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
644801005375	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
644801005376	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801005377	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
644801005378	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
644801005379	Ligand binding site [chemical binding]; other site
644801005380	Electron transfer flavoprotein domain; Region: ETF; pfam01012
644801005381	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
644801005382	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
644801005383	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
644801005384	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801005385	substrate binding pocket [chemical binding]; other site
644801005386	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
644801005387	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
644801005388	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801005389	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801005390	ligand binding site [chemical binding]; other site
644801005391	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
644801005392	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801005393	DNA-binding site [nucleotide binding]; DNA binding site
644801005394	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801005395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801005396	homodimer interface [polypeptide binding]; other site
644801005397	catalytic residue [active]
644801005398	CHASE4 domain; Region: CHASE4; pfam05228
644801005399	PAS domain S-box; Region: sensory_box; TIGR00229
644801005400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801005401	putative active site [active]
644801005402	heme pocket [chemical binding]; other site
644801005403	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801005404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801005405	metal binding site [ion binding]; metal-binding site
644801005406	active site
644801005407	I-site; other site
644801005408	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801005409	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
644801005410	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
644801005411	active site
644801005412	dimer interface [polypeptide binding]; other site
644801005413	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
644801005414	Prostaglandin dehydrogenases; Region: PGDH; cd05288
644801005415	NAD(P) binding site [chemical binding]; other site
644801005416	substrate binding site [chemical binding]; other site
644801005417	dimer interface [polypeptide binding]; other site
644801005418	short chain dehydrogenase; Provisional; Region: PRK06172
644801005419	classical (c) SDRs; Region: SDR_c; cd05233
644801005420	NAD(P) binding site [chemical binding]; other site
644801005421	active site
644801005422	benzoate transporter; Region: benE; TIGR00843
644801005423	Benzoate membrane transport protein; Region: BenE; pfam03594
644801005424	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
644801005425	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
644801005426	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
644801005427	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
644801005428	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
644801005429	MgtE intracellular N domain; Region: MgtE_N; smart00924
644801005430	FliG C-terminal domain; Region: FliG_C; pfam01706
644801005431	flagellar assembly protein H; Validated; Region: fliH; PRK05687
644801005432	Flagellar assembly protein FliH; Region: FliH; pfam02108
644801005433	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
644801005434	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
644801005435	Walker A motif/ATP binding site; other site
644801005436	Walker B motif; other site
644801005437	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
644801005438	Flagellar FliJ protein; Region: FliJ; pfam02050
644801005439	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
644801005440	anti sigma factor interaction site; other site
644801005441	regulatory phosphorylation site [posttranslational modification]; other site
644801005442	Response regulator receiver domain; Region: Response_reg; pfam00072
644801005443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005444	active site
644801005445	phosphorylation site [posttranslational modification]
644801005446	intermolecular recognition site; other site
644801005447	dimerization interface [polypeptide binding]; other site
644801005448	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
644801005449	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
644801005450	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
644801005451	putative binding surface; other site
644801005452	active site
644801005453	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
644801005454	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
644801005455	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
644801005456	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
644801005457	flagellar motor switch protein; Validated; Region: fliN; PRK05698
644801005458	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
644801005459	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
644801005460	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
644801005461	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
644801005462	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
644801005463	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
644801005464	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
644801005465	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
644801005466	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
644801005467	E-class dimer interface [polypeptide binding]; other site
644801005468	P-class dimer interface [polypeptide binding]; other site
644801005469	active site
644801005470	Cu2+ binding site [ion binding]; other site
644801005471	Zn2+ binding site [ion binding]; other site
644801005472	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
644801005473	FHIPEP family; Region: FHIPEP; pfam00771
644801005474	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
644801005475	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
644801005476	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
644801005477	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
644801005478	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
644801005479	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
644801005480	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801005481	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
644801005482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801005483	DNA binding residues [nucleotide binding]
644801005484	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
644801005485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005486	active site
644801005487	phosphorylation site [posttranslational modification]
644801005488	intermolecular recognition site; other site
644801005489	dimerization interface [polypeptide binding]; other site
644801005490	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
644801005491	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801005492	putative binding surface; other site
644801005493	active site
644801005494	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
644801005495	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
644801005496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005497	ATP binding site [chemical binding]; other site
644801005498	Mg2+ binding site [ion binding]; other site
644801005499	G-X-G motif; other site
644801005500	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
644801005501	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
644801005502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005503	active site
644801005504	phosphorylation site [posttranslational modification]
644801005505	intermolecular recognition site; other site
644801005506	dimerization interface [polypeptide binding]; other site
644801005507	CheB methylesterase; Region: CheB_methylest; pfam01339
644801005508	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
644801005509	flagellar motor protein; Reviewed; Region: motC; PRK09109
644801005510	flagellar motor protein MotD; Reviewed; Region: PRK09038
644801005511	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
644801005512	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801005513	ligand binding site [chemical binding]; other site
644801005514	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
644801005515	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801005516	P-loop; other site
644801005517	Magnesium ion binding site [ion binding]; other site
644801005518	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801005519	Magnesium ion binding site [ion binding]; other site
644801005520	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
644801005521	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
644801005522	putative CheA interaction surface; other site
644801005523	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
644801005524	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801005525	active site residue [active]
644801005526	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
644801005527	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
644801005528	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
644801005529	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
644801005530	Walker A/P-loop; other site
644801005531	ATP binding site [chemical binding]; other site
644801005532	Q-loop/lid; other site
644801005533	ABC transporter signature motif; other site
644801005534	Walker B; other site
644801005535	D-loop; other site
644801005536	H-loop/switch region; other site
644801005537	heme exporter protein CcmB; Region: ccmB; TIGR01190
644801005538	heme exporter protein CcmC; Region: ccmC; TIGR01191
644801005539	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
644801005540	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
644801005541	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
644801005542	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
644801005543	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
644801005544	catalytic residues [active]
644801005545	central insert; other site
644801005546	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
644801005547	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
644801005548	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
644801005549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801005550	TPR motif; other site
644801005551	binding surface
644801005552	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
644801005553	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801005554	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
644801005555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801005556	Walker A motif; other site
644801005557	ATP binding site [chemical binding]; other site
644801005558	Walker B motif; other site
644801005559	arginine finger; other site
644801005560	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801005561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801005562	dimer interface [polypeptide binding]; other site
644801005563	phosphorylation site [posttranslational modification]
644801005564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005565	ATP binding site [chemical binding]; other site
644801005566	Mg2+ binding site [ion binding]; other site
644801005567	G-X-G motif; other site
644801005568	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801005569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005570	active site
644801005571	phosphorylation site [posttranslational modification]
644801005572	intermolecular recognition site; other site
644801005573	dimerization interface [polypeptide binding]; other site
644801005574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801005575	Walker A motif; other site
644801005576	ATP binding site [chemical binding]; other site
644801005577	Walker B motif; other site
644801005578	arginine finger; other site
644801005579	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801005580	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
644801005581	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
644801005582	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
644801005583	heat shock protein HtpX; Provisional; Region: PRK05457
644801005584	aminotransferase AlaT; Validated; Region: PRK09265
644801005585	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801005586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801005587	homodimer interface [polypeptide binding]; other site
644801005588	catalytic residue [active]
644801005589	methionine sulfoxide reductase B; Provisional; Region: PRK00222
644801005590	SelR domain; Region: SelR; pfam01641
644801005591	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
644801005592	catalytic residues [active]
644801005593	dimer interface [polypeptide binding]; other site
644801005594	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
644801005595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801005596	Walker A motif; other site
644801005597	ATP binding site [chemical binding]; other site
644801005598	Walker B motif; other site
644801005599	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801005600	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
644801005601	C-terminal domain interface [polypeptide binding]; other site
644801005602	GSH binding site (G-site) [chemical binding]; other site
644801005603	dimer interface [polypeptide binding]; other site
644801005604	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
644801005605	N-terminal domain interface [polypeptide binding]; other site
644801005606	dimer interface [polypeptide binding]; other site
644801005607	substrate binding pocket (H-site) [chemical binding]; other site
644801005608	Uncharacterized family 4; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_4; cd10161
644801005609	putative homodimer interface [polypeptide binding]; other site
644801005610	putative homotetramer interface [polypeptide binding]; other site
644801005611	putative metal binding site [ion binding]; other site
644801005612	putative homodimer-homodimer interface [polypeptide binding]; other site
644801005613	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801005614	dimerization interface [polypeptide binding]; other site
644801005615	putative DNA binding site [nucleotide binding]; other site
644801005616	putative Zn2+ binding site [ion binding]; other site
644801005617	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
644801005618	Predicted transporter component [General function prediction only]; Region: COG2391
644801005619	Predicted transporter component [General function prediction only]; Region: COG2391
644801005620	Sulphur transport; Region: Sulf_transp; pfam04143
644801005621	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
644801005622	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801005623	active site residue [active]
644801005624	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
644801005625	high affinity sulphate transporter 1; Region: sulP; TIGR00815
644801005626	Sulfate transporter family; Region: Sulfate_transp; pfam00916
644801005627	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
644801005628	Putative phosphatase (DUF442); Region: DUF442; cl17385
644801005629	hydroxyglutarate oxidase; Provisional; Region: PRK11728
644801005630	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
644801005631	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
644801005632	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
644801005633	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
644801005634	Walker A/P-loop; other site
644801005635	ATP binding site [chemical binding]; other site
644801005636	Q-loop/lid; other site
644801005637	ABC transporter signature motif; other site
644801005638	Walker B; other site
644801005639	D-loop; other site
644801005640	H-loop/switch region; other site
644801005641	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
644801005642	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
644801005643	FtsX-like permease family; Region: FtsX; pfam02687
644801005644	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
644801005645	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801005646	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
644801005647	ZIP Zinc transporter; Region: Zip; pfam02535
644801005648	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801005649	ligand binding site [chemical binding]; other site
644801005650	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
644801005651	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
644801005652	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801005653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
644801005654	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
644801005655	elongation factor P; Validated; Region: PRK00529
644801005656	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
644801005657	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
644801005658	RNA binding site [nucleotide binding]; other site
644801005659	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
644801005660	RNA binding site [nucleotide binding]; other site
644801005661	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
644801005662	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
644801005663	transmembrane helices; other site
644801005664	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
644801005665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801005666	S-adenosylmethionine binding site [chemical binding]; other site
644801005667	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801005668	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801005669	dimer interface [polypeptide binding]; other site
644801005670	putative CheW interface [polypeptide binding]; other site
644801005671	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
644801005672	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
644801005673	ATP binding site [chemical binding]; other site
644801005674	Mg++ binding site [ion binding]; other site
644801005675	motif III; other site
644801005676	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801005677	nucleotide binding region [chemical binding]; other site
644801005678	ATP-binding site [chemical binding]; other site
644801005679	DbpA RNA binding domain; Region: DbpA; pfam03880
644801005680	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
644801005681	IHF dimer interface [polypeptide binding]; other site
644801005682	IHF - DNA interface [nucleotide binding]; other site
644801005683	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
644801005684	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
644801005685	Chain length determinant protein; Region: Wzz; pfam02706
644801005686	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
644801005687	Beta-Casp domain; Region: Beta-Casp; smart01027
644801005688	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
644801005689	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
644801005690	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
644801005691	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
644801005692	NAD(P) binding site [chemical binding]; other site
644801005693	homodimer interface [polypeptide binding]; other site
644801005694	substrate binding site [chemical binding]; other site
644801005695	active site
644801005696	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
644801005697	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
644801005698	inhibitor-cofactor binding pocket; inhibition site
644801005699	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801005700	catalytic residue [active]
644801005701	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
644801005702	ligand binding site; other site
644801005703	tetramer interface; other site
644801005704	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
644801005705	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
644801005706	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
644801005707	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
644801005708	pseudaminic acid synthase; Region: PseI; TIGR03586
644801005709	NeuB family; Region: NeuB; pfam03102
644801005710	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
644801005711	NeuB binding interface [polypeptide binding]; other site
644801005712	putative substrate binding site [chemical binding]; other site
644801005713	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
644801005714	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
644801005715	NADP-binding site; other site
644801005716	homotetramer interface [polypeptide binding]; other site
644801005717	substrate binding site [chemical binding]; other site
644801005718	homodimer interface [polypeptide binding]; other site
644801005719	active site
644801005720	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
644801005721	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
644801005722	NADP binding site [chemical binding]; other site
644801005723	active site
644801005724	putative substrate binding site [chemical binding]; other site
644801005725	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
644801005726	active site
644801005727	GDP-Mannose binding site [chemical binding]; other site
644801005728	dimer interface [polypeptide binding]; other site
644801005729	modified nudix motif
644801005730	metal binding site [ion binding]; metal-binding site
644801005731	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
644801005732	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
644801005733	Substrate binding site; other site
644801005734	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
644801005735	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
644801005736	metal-binding site
644801005737	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
644801005738	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
644801005739	putative NAD(P) binding site [chemical binding]; other site
644801005740	active site
644801005741	putative substrate binding site [chemical binding]; other site
644801005742	Bacterial sugar transferase; Region: Bac_transf; pfam02397
644801005743	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
644801005744	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
644801005745	NAD(P) binding site [chemical binding]; other site
644801005746	homodimer interface [polypeptide binding]; other site
644801005747	substrate binding site [chemical binding]; other site
644801005748	active site
644801005749	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
644801005750	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
644801005751	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
644801005752	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
644801005753	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
644801005754	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
644801005755	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
644801005756	dimer interface [polypeptide binding]; other site
644801005757	active site
644801005758	polysaccharide export protein Wza; Provisional; Region: PRK15078
644801005759	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
644801005760	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
644801005761	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
644801005762	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
644801005763	Probable Catalytic site; other site
644801005764	metal-binding site
644801005765	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
644801005766	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
644801005767	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
644801005768	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
644801005769	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
644801005770	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
644801005771	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
644801005772	tyrosine kinase; Provisional; Region: PRK11519
644801005773	Chain length determinant protein; Region: Wzz; pfam02706
644801005774	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
644801005775	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
644801005776	Low molecular weight phosphatase family; Region: LMWPc; cd00115
644801005777	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
644801005778	active site
644801005779	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
644801005780	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
644801005781	lipid kinase; Reviewed; Region: PRK13054
644801005782	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
644801005783	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
644801005784	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801005785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005786	active site
644801005787	phosphorylation site [posttranslational modification]
644801005788	intermolecular recognition site; other site
644801005789	dimerization interface [polypeptide binding]; other site
644801005790	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
644801005791	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
644801005792	MOSC domain; Region: MOSC; pfam03473
644801005793	lytic murein transglycosylase; Provisional; Region: PRK11619
644801005794	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801005795	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801005796	catalytic residue [active]
644801005797	ABC transporter ATPase component; Reviewed; Region: PRK11147
644801005798	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801005799	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801005800	ABC transporter; Region: ABC_tran_2; pfam12848
644801005801	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801005802	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801005803	Ligand Binding Site [chemical binding]; other site
644801005804	Vpu protein; Region: Vpu; pfam00558
644801005805	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
644801005806	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
644801005807	putative active site [active]
644801005808	putative dimer interface [polypeptide binding]; other site
644801005809	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
644801005810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
644801005811	Uncharacterized conserved protein [Function unknown]; Region: COG3791
644801005812	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
644801005813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801005814	Walker A motif; other site
644801005815	ATP binding site [chemical binding]; other site
644801005816	Walker B motif; other site
644801005817	arginine finger; other site
644801005818	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
644801005819	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
644801005820	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
644801005821	dimer interface [polypeptide binding]; other site
644801005822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801005823	catalytic residue [active]
644801005824	EamA-like transporter family; Region: EamA; pfam00892
644801005825	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
644801005826	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
644801005827	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
644801005828	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801005829	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
644801005830	putative C-terminal domain interface [polypeptide binding]; other site
644801005831	putative GSH binding site (G-site) [chemical binding]; other site
644801005832	putative dimer interface [polypeptide binding]; other site
644801005833	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
644801005834	putative N-terminal domain interface [polypeptide binding]; other site
644801005835	putative dimer interface [polypeptide binding]; other site
644801005836	putative substrate binding pocket (H-site) [chemical binding]; other site
644801005837	Uncharacterized conserved protein [Function unknown]; Region: COG3148
644801005838	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
644801005839	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801005840	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801005841	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005842	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005843	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005844	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005845	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005846	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005847	VCBS repeat; Region: VCBS_repeat; TIGR01965
644801005848	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
644801005849	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801005850	dimerization interface [polypeptide binding]; other site
644801005851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801005852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801005853	metal binding site [ion binding]; metal-binding site
644801005854	active site
644801005855	I-site; other site
644801005856	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801005857	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
644801005858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
644801005859	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
644801005860	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
644801005861	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
644801005862	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801005863	ATP binding site [chemical binding]; other site
644801005864	putative Mg++ binding site [ion binding]; other site
644801005865	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801005866	nucleotide binding region [chemical binding]; other site
644801005867	ATP-binding site [chemical binding]; other site
644801005868	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
644801005869	HRDC domain; Region: HRDC; pfam00570
644801005870	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
644801005871	MarR family; Region: MarR_2; pfam12802
644801005872	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
644801005873	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
644801005874	active site
644801005875	nucleophile elbow; other site
644801005876	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
644801005877	Surface antigen; Region: Bac_surface_Ag; pfam01103
644801005878	Rdx family; Region: Rdx; cl01407
644801005879	EamA-like transporter family; Region: EamA; pfam00892
644801005880	Cupin domain; Region: Cupin_2; cl17218
644801005881	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801005882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801005883	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801005884	MASE2 domain; Region: MASE2; pfam05230
644801005885	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
644801005886	cyclase homology domain; Region: CHD; cd07302
644801005887	nucleotidyl binding site; other site
644801005888	metal binding site [ion binding]; metal-binding site
644801005889	dimer interface [polypeptide binding]; other site
644801005890	Protein of unknown function (DUF962); Region: DUF962; cl01879
644801005891	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
644801005892	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801005893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801005894	Protein of unknown function (DUF808); Region: DUF808; pfam05661
644801005895	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
644801005896	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
644801005897	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
644801005898	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
644801005899	putative FMN binding site [chemical binding]; other site
644801005900	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801005901	HAMP domain; Region: HAMP; pfam00672
644801005902	dimerization interface [polypeptide binding]; other site
644801005903	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
644801005904	phosphorylation site [posttranslational modification]
644801005905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005906	ATP binding site [chemical binding]; other site
644801005907	G-X-G motif; other site
644801005908	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
644801005909	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
644801005910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005911	active site
644801005912	phosphorylation site [posttranslational modification]
644801005913	intermolecular recognition site; other site
644801005914	dimerization interface [polypeptide binding]; other site
644801005915	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801005916	DNA binding site [nucleotide binding]
644801005917	YciI-like protein; Reviewed; Region: PRK11370
644801005918	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
644801005919	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
644801005920	active site
644801005921	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
644801005922	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
644801005923	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
644801005924	active site
644801005925	HIGH motif; other site
644801005926	dimer interface [polypeptide binding]; other site
644801005927	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
644801005928	active site
644801005929	KMSKS motif; other site
644801005930	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
644801005931	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
644801005932	phosphogluconate dehydratase; Validated; Region: PRK09054
644801005933	6-phosphogluconate dehydratase; Region: edd; TIGR01196
644801005934	glucokinase, proteobacterial type; Region: glk; TIGR00749
644801005935	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
644801005936	nucleotide binding site [chemical binding]; other site
644801005937	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
644801005938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801005939	active site
644801005940	phosphorylation site [posttranslational modification]
644801005941	intermolecular recognition site; other site
644801005942	dimerization interface [polypeptide binding]; other site
644801005943	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801005944	DNA binding site [nucleotide binding]
644801005945	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801005946	dimerization interface [polypeptide binding]; other site
644801005947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801005948	ATP binding site [chemical binding]; other site
644801005949	Mg2+ binding site [ion binding]; other site
644801005950	G-X-G motif; other site
644801005951	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
644801005952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
644801005953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801005954	dimer interface [polypeptide binding]; other site
644801005955	conserved gate region; other site
644801005956	putative PBP binding loops; other site
644801005957	ABC-ATPase subunit interface; other site
644801005958	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
644801005959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801005960	dimer interface [polypeptide binding]; other site
644801005961	conserved gate region; other site
644801005962	putative PBP binding loops; other site
644801005963	ABC-ATPase subunit interface; other site
644801005964	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
644801005965	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
644801005966	Walker A/P-loop; other site
644801005967	ATP binding site [chemical binding]; other site
644801005968	Q-loop/lid; other site
644801005969	ABC transporter signature motif; other site
644801005970	Walker B; other site
644801005971	D-loop; other site
644801005972	H-loop/switch region; other site
644801005973	TOBE domain; Region: TOBE_2; pfam08402
644801005974	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
644801005975	trimer interface; other site
644801005976	sugar binding site [chemical binding]; other site
644801005977	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
644801005978	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
644801005979	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
644801005980	Tetramer interface [polypeptide binding]; other site
644801005981	active site
644801005982	FMN-binding site [chemical binding]; other site
644801005983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801005984	Major Facilitator Superfamily; Region: MFS_1; pfam07690
644801005985	putative substrate translocation pore; other site
644801005986	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
644801005987	Cupin domain; Region: Cupin_2; cl17218
644801005988	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
644801005989	catalytic core [active]
644801005990	AlkA N-terminal domain; Region: AlkA_N; pfam06029
644801005991	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
644801005992	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
644801005993	minor groove reading motif; other site
644801005994	helix-hairpin-helix signature motif; other site
644801005995	substrate binding pocket [chemical binding]; other site
644801005996	active site
644801005997	spermidine synthase; Provisional; Region: PRK00811
644801005998	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801005999	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
644801006000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801006001	LysR family transcriptional regulator; Provisional; Region: PRK14997
644801006002	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801006003	putative effector binding pocket; other site
644801006004	dimerization interface [polypeptide binding]; other site
644801006005	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
644801006006	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
644801006007	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
644801006008	Chromate transporter; Region: Chromate_transp; pfam02417
644801006009	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
644801006010	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
644801006011	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
644801006012	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
644801006013	active site
644801006014	metal binding site [ion binding]; metal-binding site
644801006015	Rhomboid family; Region: Rhomboid; pfam01694
644801006016	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
644801006017	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
644801006018	aminopeptidase N; Provisional; Region: pepN; PRK14015
644801006019	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
644801006020	active site
644801006021	Zn binding site [ion binding]; other site
644801006022	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
644801006023	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
644801006024	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
644801006025	active site
644801006026	SAM binding site [chemical binding]; other site
644801006027	homodimer interface [polypeptide binding]; other site
644801006028	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
644801006029	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
644801006030	[4Fe-4S] binding site [ion binding]; other site
644801006031	molybdopterin cofactor binding site; other site
644801006032	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
644801006033	molybdopterin cofactor binding site; other site
644801006034	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
644801006035	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
644801006036	[2Fe-2S] cluster binding site [ion binding]; other site
644801006037	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
644801006038	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801006039	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
644801006040	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
644801006041	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
644801006042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
644801006043	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
644801006044	active site
644801006045	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
644801006046	Catalytic domain of Protein Kinases; Region: PKc; cd00180
644801006047	active site
644801006048	ATP binding site [chemical binding]; other site
644801006049	substrate binding site [chemical binding]; other site
644801006050	activation loop (A-loop); other site
644801006051	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
644801006052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801006053	putative substrate translocation pore; other site
644801006054	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
644801006055	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
644801006056	putative substrate binding site [chemical binding]; other site
644801006057	putative ATP binding site [chemical binding]; other site
644801006058	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
644801006059	active site
644801006060	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
644801006061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801006062	active site
644801006063	phosphorylation site [posttranslational modification]
644801006064	intermolecular recognition site; other site
644801006065	dimerization interface [polypeptide binding]; other site
644801006066	ANTAR domain; Region: ANTAR; pfam03861
644801006067	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801006068	NMT1-like family; Region: NMT1_2; pfam13379
644801006069	Oxygen tolerance; Region: BatD; pfam13584
644801006070	von Willebrand factor type A domain; Region: VWA_2; pfam13519
644801006071	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801006072	TPR motif; other site
644801006073	binding surface
644801006074	TPR repeat; Region: TPR_11; pfam13414
644801006075	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
644801006076	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
644801006077	metal ion-dependent adhesion site (MIDAS); other site
644801006078	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
644801006079	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
644801006080	Protein of unknown function DUF58; Region: DUF58; pfam01882
644801006081	MoxR-like ATPases [General function prediction only]; Region: COG0714
644801006082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801006083	Walker A motif; other site
644801006084	ATP binding site [chemical binding]; other site
644801006085	Walker B motif; other site
644801006086	arginine finger; other site
644801006087	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
644801006088	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
644801006089	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
644801006090	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
644801006091	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
644801006092	quinone interaction residues [chemical binding]; other site
644801006093	active site
644801006094	catalytic residues [active]
644801006095	FMN binding site [chemical binding]; other site
644801006096	substrate binding site [chemical binding]; other site
644801006097	Ribosome modulation factor [Translation, ribosomal structure and biogenesis]; Region: Rmf; COG3130
644801006098	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
644801006099	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
644801006100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
644801006101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801006102	S-adenosylmethionine binding site [chemical binding]; other site
644801006103	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
644801006104	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
644801006105	hypothetical protein; Provisional; Region: PRK11702
644801006106	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
644801006107	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801006108	Zn2+ binding site [ion binding]; other site
644801006109	Mg2+ binding site [ion binding]; other site
644801006110	Predicted membrane protein [Function unknown]; Region: COG5393
644801006111	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
644801006112	outer membrane porin, OprD family; Region: OprD; pfam03573
644801006113	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
644801006114	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
644801006115	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
644801006116	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
644801006117	GTP binding site; other site
644801006118	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
644801006119	Acyltransferase family; Region: Acyl_transf_3; pfam01757
644801006120	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
644801006121	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cl12104
644801006122	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
644801006123	putative active site [active]
644801006124	TPR repeat; Region: TPR_11; pfam13414
644801006125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801006126	binding surface
644801006127	TPR motif; other site
644801006128	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
644801006129	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
644801006130	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
644801006131	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
644801006132	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
644801006133	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
644801006134	active site
644801006135	dimer interface [polypeptide binding]; other site
644801006136	motif 1; other site
644801006137	motif 2; other site
644801006138	motif 3; other site
644801006139	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
644801006140	anticodon binding site; other site
644801006141	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
644801006142	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
644801006143	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
644801006144	Long range pseudoknot; Psest_1970
644801006145	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
644801006146	23S rRNA binding site [nucleotide binding]; other site
644801006147	L21 binding site [polypeptide binding]; other site
644801006148	L13 binding site [polypeptide binding]; other site
644801006149	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
644801006150	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
644801006151	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
644801006152	dimer interface [polypeptide binding]; other site
644801006153	motif 1; other site
644801006154	active site
644801006155	motif 2; other site
644801006156	motif 3; other site
644801006157	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
644801006158	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
644801006159	putative tRNA-binding site [nucleotide binding]; other site
644801006160	B3/4 domain; Region: B3_4; pfam03483
644801006161	tRNA synthetase B5 domain; Region: B5; smart00874
644801006162	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
644801006163	dimer interface [polypeptide binding]; other site
644801006164	motif 1; other site
644801006165	motif 3; other site
644801006166	motif 2; other site
644801006167	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
644801006168	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
644801006169	IHF dimer interface [polypeptide binding]; other site
644801006170	IHF - DNA interface [nucleotide binding]; other site
644801006171	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
644801006172	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
644801006173	DNA binding residues [nucleotide binding]
644801006174	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
644801006175	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
644801006176	putative active site [active]
644801006177	putative PHP Thumb interface [polypeptide binding]; other site
644801006178	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
644801006179	generic binding surface I; other site
644801006180	generic binding surface II; other site
644801006181	DNA Polymerase Y-family; Region: PolY_like; cd03468
644801006182	active site
644801006183	DNA binding site [nucleotide binding]
644801006184	Uncharacterized conserved protein [Function unknown]; Region: COG4544
644801006185	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
644801006186	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
644801006187	DNA gyrase subunit A; Validated; Region: PRK05560
644801006188	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
644801006189	CAP-like domain; other site
644801006190	active site
644801006191	primary dimer interface [polypeptide binding]; other site
644801006192	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
644801006193	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
644801006194	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
644801006195	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
644801006196	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
644801006197	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
644801006198	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
644801006199	homodimer interface [polypeptide binding]; other site
644801006200	substrate-cofactor binding pocket; other site
644801006201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801006202	catalytic residue [active]
644801006203	chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807
644801006204	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
644801006205	Prephenate dehydratase; Region: PDT; pfam00800
644801006206	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
644801006207	putative L-Phe binding site [chemical binding]; other site
644801006208	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
644801006209	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801006210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801006211	homodimer interface [polypeptide binding]; other site
644801006212	catalytic residue [active]
644801006213	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
644801006214	prephenate dehydrogenase; Validated; Region: PRK08507
644801006215	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
644801006216	hinge; other site
644801006217	active site
644801006218	cytidylate kinase; Provisional; Region: cmk; PRK00023
644801006219	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
644801006220	CMP-binding site; other site
644801006221	The sites determining sugar specificity; other site
644801006222	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
644801006223	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
644801006224	RNA binding site [nucleotide binding]; other site
644801006225	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
644801006226	RNA binding site [nucleotide binding]; other site
644801006227	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
644801006228	RNA binding site [nucleotide binding]; other site
644801006229	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
644801006230	RNA binding site [nucleotide binding]; other site
644801006231	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
644801006232	RNA binding site [nucleotide binding]; other site
644801006233	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
644801006234	RNA binding site [nucleotide binding]; other site
644801006235	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
644801006236	MarR family; Region: MarR_2; pfam12802
644801006237	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
644801006238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801006239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801006240	homodimer interface [polypeptide binding]; other site
644801006241	catalytic residue [active]
644801006242	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801006243	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
644801006244	putative C-terminal domain interface [polypeptide binding]; other site
644801006245	putative GSH binding site (G-site) [chemical binding]; other site
644801006246	putative dimer interface [polypeptide binding]; other site
644801006247	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
644801006248	N-terminal domain interface [polypeptide binding]; other site
644801006249	dimer interface [polypeptide binding]; other site
644801006250	substrate binding pocket (H-site) [chemical binding]; other site
644801006251	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
644801006252	homodecamer interface [polypeptide binding]; other site
644801006253	GTP cyclohydrolase I; Provisional; Region: PLN03044
644801006254	active site
644801006255	putative catalytic site residues [active]
644801006256	zinc binding site [ion binding]; other site
644801006257	GTP-CH-I/GFRP interaction surface; other site
644801006258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
644801006259	Smr domain; Region: Smr; pfam01713
644801006260	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
644801006261	Isochorismatase family; Region: Isochorismatase; pfam00857
644801006262	catalytic triad [active]
644801006263	conserved cis-peptide bond; other site
644801006264	HemK family putative methylases; Region: hemK_fam; TIGR00536
644801006265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801006266	S-adenosylmethionine binding site [chemical binding]; other site
644801006267	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
644801006268	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
644801006269	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
644801006270	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
644801006271	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
644801006272	putative active site [active]
644801006273	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
644801006274	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
644801006275	active site
644801006276	intersubunit interface [polypeptide binding]; other site
644801006277	catalytic residue [active]
644801006278	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
644801006279	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801006280	RNA binding surface [nucleotide binding]; other site
644801006281	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
644801006282	probable active site [active]
644801006283	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
644801006284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801006285	NAD(P) binding site [chemical binding]; other site
644801006286	active site
644801006287	phosphoglycolate phosphatase; Provisional; Region: PRK13222
644801006288	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801006289	motif II; other site
644801006290	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
644801006291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801006292	S-adenosylmethionine binding site [chemical binding]; other site
644801006293	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
644801006294	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
644801006295	active site
644801006296	putative substrate binding pocket [chemical binding]; other site
644801006297	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
644801006298	active site
644801006299	Predicted permease [General function prediction only]; Region: COG2056
644801006300	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
644801006301	Domain of unknown function DUF20; Region: UPF0118; pfam01594
644801006302	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
644801006303	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
644801006304	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
644801006305	tetramer interface [polypeptide binding]; other site
644801006306	active site
644801006307	Mg2+/Mn2+ binding site [ion binding]; other site
644801006308	isocitrate lyase; Region: PLN02892
644801006309	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
644801006310	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
644801006311	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
644801006312	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801006313	Coenzyme A binding pocket [chemical binding]; other site
644801006314	Uncharacterized conserved protein [Function unknown]; Region: COG2850
644801006315	adenylosuccinate lyase; Provisional; Region: PRK09285
644801006316	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
644801006317	tetramer interface [polypeptide binding]; other site
644801006318	active site
644801006319	putative lysogenization regulator; Reviewed; Region: PRK00218
644801006320	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
644801006321	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
644801006322	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
644801006323	nudix motif; other site
644801006324	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
644801006325	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
644801006326	isocitrate dehydrogenase; Validated; Region: PRK07362
644801006327	isocitrate dehydrogenase; Reviewed; Region: PRK07006
644801006328	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801006329	DNA-binding site [nucleotide binding]; DNA binding site
644801006330	RNA-binding motif; other site
644801006331	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
644801006332	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
644801006333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801006334	Walker A motif; other site
644801006335	ATP binding site [chemical binding]; other site
644801006336	Walker B motif; other site
644801006337	arginine finger; other site
644801006338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801006339	Walker A motif; other site
644801006340	ATP binding site [chemical binding]; other site
644801006341	Walker B motif; other site
644801006342	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
644801006343	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
644801006344	rRNA binding site [nucleotide binding]; other site
644801006345	predicted 30S ribosome binding site; other site
644801006346	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
644801006347	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
644801006348	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
644801006349	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
644801006350	thioredoxin reductase; Provisional; Region: PRK10262
644801006351	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801006352	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801006353	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
644801006354	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
644801006355	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
644801006356	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
644801006357	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
644801006358	recombination factor protein RarA; Reviewed; Region: PRK13342
644801006359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801006360	Walker A motif; other site
644801006361	ATP binding site [chemical binding]; other site
644801006362	Walker B motif; other site
644801006363	arginine finger; other site
644801006364	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
644801006365	camphor resistance protein CrcB; Provisional; Region: PRK14234
644801006366	seryl-tRNA synthetase; Provisional; Region: PRK05431
644801006367	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
644801006368	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
644801006369	dimer interface [polypeptide binding]; other site
644801006370	active site
644801006371	motif 1; other site
644801006372	motif 2; other site
644801006373	motif 3; other site
644801006374	siroheme synthase; Provisional; Region: cysG; PRK10637
644801006375	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
644801006376	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
644801006377	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
644801006378	active site
644801006379	SAM binding site [chemical binding]; other site
644801006380	homodimer interface [polypeptide binding]; other site
644801006381	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801006382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801006383	active site
644801006384	phosphorylation site [posttranslational modification]
644801006385	intermolecular recognition site; other site
644801006386	dimerization interface [polypeptide binding]; other site
644801006387	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801006388	DNA binding residues [nucleotide binding]
644801006389	dimerization interface [polypeptide binding]; other site
644801006390	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801006391	active site residue [active]
644801006392	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
644801006393	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
644801006394	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
644801006395	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801006396	Walker A/P-loop; other site
644801006397	ATP binding site [chemical binding]; other site
644801006398	Q-loop/lid; other site
644801006399	ABC transporter signature motif; other site
644801006400	Walker B; other site
644801006401	D-loop; other site
644801006402	H-loop/switch region; other site
644801006403	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
644801006404	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
644801006405	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
644801006406	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
644801006407	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
644801006408	Sel1-like repeats; Region: SEL1; smart00671
644801006409	Sel1 repeat; Region: Sel1; cl02723
644801006410	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
644801006411	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
644801006412	ligand binding site [chemical binding]; other site
644801006413	Cache domain; Region: Cache_1; pfam02743
644801006414	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801006415	dimerization interface [polypeptide binding]; other site
644801006416	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801006417	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801006418	dimer interface [polypeptide binding]; other site
644801006419	putative CheW interface [polypeptide binding]; other site
644801006420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801006421	dimerization interface [polypeptide binding]; other site
644801006422	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
644801006423	Histidine kinase; Region: HisKA_3; pfam07730
644801006424	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
644801006425	ATP binding site [chemical binding]; other site
644801006426	Mg2+ binding site [ion binding]; other site
644801006427	G-X-G motif; other site
644801006428	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801006429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801006430	active site
644801006431	phosphorylation site [posttranslational modification]
644801006432	intermolecular recognition site; other site
644801006433	dimerization interface [polypeptide binding]; other site
644801006434	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801006435	DNA binding residues [nucleotide binding]
644801006436	dimerization interface [polypeptide binding]; other site
644801006437	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
644801006438	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801006439	N-terminal plug; other site
644801006440	ligand-binding site [chemical binding]; other site
644801006441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801006442	putative substrate translocation pore; other site
644801006443	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
644801006444	catalytic site [active]
644801006445	putative active site [active]
644801006446	putative substrate binding site [chemical binding]; other site
644801006447	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
644801006448	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801006449	PAS domain; Region: PAS_9; pfam13426
644801006450	putative active site [active]
644801006451	heme pocket [chemical binding]; other site
644801006452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801006453	PAS domain; Region: PAS_9; pfam13426
644801006454	putative active site [active]
644801006455	heme pocket [chemical binding]; other site
644801006456	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801006457	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801006458	dimer interface [polypeptide binding]; other site
644801006459	putative CheW interface [polypeptide binding]; other site
644801006460	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
644801006461	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
644801006462	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
644801006463	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
644801006464	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
644801006465	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
644801006466	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
644801006467	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
644801006468	dimer interface [polypeptide binding]; other site
644801006469	Trp docking motif [polypeptide binding]; other site
644801006470	active site
644801006471	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801006472	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801006473	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801006474	substrate binding pocket [chemical binding]; other site
644801006475	membrane-bound complex binding site; other site
644801006476	hinge residues; other site
644801006477	Predicted secreted protein [Function unknown]; Region: COG5501
644801006478	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
644801006479	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
644801006480	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
644801006481	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
644801006482	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
644801006483	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
644801006484	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
644801006485	dimer interface [polypeptide binding]; other site
644801006486	Trp docking motif [polypeptide binding]; other site
644801006487	active site
644801006488	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801006489	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801006490	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801006491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801006492	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
644801006493	classical (c) SDRs; Region: SDR_c; cd05233
644801006494	NAD(P) binding site [chemical binding]; other site
644801006495	active site
644801006496	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
644801006497	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
644801006498	NAD binding site [chemical binding]; other site
644801006499	homotetramer interface [polypeptide binding]; other site
644801006500	homodimer interface [polypeptide binding]; other site
644801006501	substrate binding site [chemical binding]; other site
644801006502	active site
644801006503	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
644801006504	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
644801006505	Walker A/P-loop; other site
644801006506	ATP binding site [chemical binding]; other site
644801006507	Q-loop/lid; other site
644801006508	ABC transporter signature motif; other site
644801006509	Walker B; other site
644801006510	D-loop; other site
644801006511	H-loop/switch region; other site
644801006512	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
644801006513	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
644801006514	Walker A/P-loop; other site
644801006515	ATP binding site [chemical binding]; other site
644801006516	Q-loop/lid; other site
644801006517	ABC transporter signature motif; other site
644801006518	Walker B; other site
644801006519	D-loop; other site
644801006520	H-loop/switch region; other site
644801006521	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
644801006522	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
644801006523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801006524	dimer interface [polypeptide binding]; other site
644801006525	conserved gate region; other site
644801006526	putative PBP binding loops; other site
644801006527	ABC-ATPase subunit interface; other site
644801006528	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
644801006529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801006530	dimer interface [polypeptide binding]; other site
644801006531	conserved gate region; other site
644801006532	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
644801006533	ABC-ATPase subunit interface; other site
644801006534	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
644801006535	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
644801006536	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
644801006537	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
644801006538	HDOD domain; Region: HDOD; pfam08668
644801006539	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
644801006540	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801006541	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801006542	catalytic residue [active]
644801006543	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801006544	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801006545	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801006546	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
644801006547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801006548	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
644801006549	RNA/DNA hybrid binding site [nucleotide binding]; other site
644801006550	active site
644801006551	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
644801006552	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
644801006553	active site
644801006554	catalytic site [active]
644801006555	substrate binding site [chemical binding]; other site
644801006556	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
644801006557	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
644801006558	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
644801006559	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801006560	catalytic residue [active]
644801006561	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
644801006562	enoyl-CoA hydratase; Provisional; Region: PRK06142
644801006563	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801006564	substrate binding site [chemical binding]; other site
644801006565	oxyanion hole (OAH) forming residues; other site
644801006566	trimer interface [polypeptide binding]; other site
644801006567	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
644801006568	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
644801006569	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
644801006570	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
644801006571	putative NADH binding site [chemical binding]; other site
644801006572	putative active site [active]
644801006573	nudix motif; other site
644801006574	putative metal binding site [ion binding]; other site
644801006575	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
644801006576	hypothetical protein; Provisional; Region: PRK10621
644801006577	short chain dehydrogenase; Provisional; Region: PRK07035
644801006578	classical (c) SDRs; Region: SDR_c; cd05233
644801006579	NAD(P) binding site [chemical binding]; other site
644801006580	active site
644801006581	Phosphotransferase enzyme family; Region: APH; pfam01636
644801006582	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
644801006583	putative active site [active]
644801006584	putative substrate binding site [chemical binding]; other site
644801006585	ATP binding site [chemical binding]; other site
644801006586	SCP-2 sterol transfer family; Region: SCP2; pfam02036
644801006587	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
644801006588	catalytic core [active]
644801006589	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
644801006590	putative inner membrane peptidase; Provisional; Region: PRK11778
644801006591	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
644801006592	tandem repeat interface [polypeptide binding]; other site
644801006593	oligomer interface [polypeptide binding]; other site
644801006594	active site residues [active]
644801006595	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
644801006596	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
644801006597	NADP binding site [chemical binding]; other site
644801006598	dimer interface [polypeptide binding]; other site
644801006599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
644801006600	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
644801006601	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
644801006602	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
644801006603	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
644801006604	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
644801006605	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
644801006606	putative dimer interface [polypeptide binding]; other site
644801006607	Leucine rich repeat; Region: LRR_8; pfam13855
644801006608	Leucine rich repeat; Region: LRR_8; pfam13855
644801006609	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
644801006610	Catalytic domain of Protein Kinases; Region: PKc; cd00180
644801006611	active site
644801006612	ATP binding site [chemical binding]; other site
644801006613	substrate binding site [chemical binding]; other site
644801006614	activation loop (A-loop); other site
644801006615	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464
644801006616	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801006617	FeS/SAM binding site; other site
644801006618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801006619	putative substrate translocation pore; other site
644801006620	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
644801006621	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
644801006622	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
644801006623	AAA domain; Region: AAA_28; pfam13521
644801006624	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
644801006625	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
644801006626	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
644801006627	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
644801006628	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
644801006629	substrate binding pocket [chemical binding]; other site
644801006630	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
644801006631	B12 binding site [chemical binding]; other site
644801006632	cobalt ligand [ion binding]; other site
644801006633	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
644801006634	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
644801006635	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
644801006636	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
644801006637	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
644801006638	Response regulator receiver domain; Region: Response_reg; pfam00072
644801006639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801006640	active site
644801006641	phosphorylation site [posttranslational modification]
644801006642	intermolecular recognition site; other site
644801006643	dimerization interface [polypeptide binding]; other site
644801006644	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
644801006645	PAS fold; Region: PAS_4; pfam08448
644801006646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801006647	putative active site [active]
644801006648	heme pocket [chemical binding]; other site
644801006649	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801006650	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801006651	metal binding site [ion binding]; metal-binding site
644801006652	active site
644801006653	I-site; other site
644801006654	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
644801006655	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
644801006656	active site
644801006657	DNA binding site [nucleotide binding]
644801006658	Int/Topo IB signature motif; other site
644801006659	catalytic residues [active]
644801006660	Predicted membrane protein [Function unknown]; Region: COG2323
644801006661	Cache domain; Region: Cache_2; pfam08269
644801006662	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801006663	dimerization interface [polypeptide binding]; other site
644801006664	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801006665	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801006666	dimer interface [polypeptide binding]; other site
644801006667	putative CheW interface [polypeptide binding]; other site
644801006668	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
644801006669	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
644801006670	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
644801006671	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
644801006672	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801006673	Walker A/P-loop; other site
644801006674	ATP binding site [chemical binding]; other site
644801006675	Q-loop/lid; other site
644801006676	ABC transporter signature motif; other site
644801006677	Walker B; other site
644801006678	D-loop; other site
644801006679	H-loop/switch region; other site
644801006680	ABC transporter; Region: ABC_tran_2; pfam12848
644801006681	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801006682	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
644801006683	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801006684	N-terminal plug; other site
644801006685	ligand-binding site [chemical binding]; other site
644801006686	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
644801006687	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
644801006688	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
644801006689	homotrimer interaction site [polypeptide binding]; other site
644801006690	putative active site [active]
644801006691	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
644801006692	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801006693	hydroxyglutarate oxidase; Provisional; Region: PRK11728
644801006694	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
644801006695	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801006696	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801006697	dimerization interface [polypeptide binding]; other site
644801006698	Predicted ATPase [General function prediction only]; Region: COG1485
644801006699	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
644801006700	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
644801006701	AAA domain; Region: AAA_33; pfam13671
644801006702	ATP-binding site [chemical binding]; other site
644801006703	Gluconate-6-phosphate binding site [chemical binding]; other site
644801006704	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
644801006705	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
644801006706	DctM-like transporters; Region: DctM; pfam06808
644801006707	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801006708	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801006709	Transcriptional regulators [Transcription]; Region: PurR; COG1609
644801006710	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
644801006711	DNA binding site [nucleotide binding]
644801006712	domain linker motif; other site
644801006713	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
644801006714	putative ligand binding site [chemical binding]; other site
644801006715	putative dimerization interface [polypeptide binding]; other site
644801006716	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
644801006717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801006718	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
644801006719	substrate binding pocket [chemical binding]; other site
644801006720	dimerization interface [polypeptide binding]; other site
644801006721	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801006722	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
644801006723	FAD binding site [chemical binding]; other site
644801006724	substrate binding site [chemical binding]; other site
644801006725	catalytic base [active]
644801006726	PBP superfamily domain; Region: PBP_like_2; cl17296
644801006727	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801006728	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801006729	ligand binding site [chemical binding]; other site
644801006730	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
644801006731	putative catalytic site [active]
644801006732	putative phosphate binding site [ion binding]; other site
644801006733	active site
644801006734	metal binding site A [ion binding]; metal-binding site
644801006735	DNA binding site [nucleotide binding]
644801006736	putative AP binding site [nucleotide binding]; other site
644801006737	putative metal binding site B [ion binding]; other site
644801006738	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
644801006739	Coenzyme A binding pocket [chemical binding]; other site
644801006740	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
644801006741	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
644801006742	Surface antigen; Region: Bac_surface_Ag; pfam01103
644801006743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
644801006744	Family of unknown function (DUF490); Region: DUF490; pfam04357
644801006745	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
644801006746	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
644801006747	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
644801006748	dimer interface [polypeptide binding]; other site
644801006749	catalytic triad [active]
644801006750	peroxidatic and resolving cysteines [active]
644801006751	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
644801006752	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
644801006753	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
644801006754	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
644801006755	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
644801006756	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801006757	E3 interaction surface; other site
644801006758	lipoyl attachment site [posttranslational modification]; other site
644801006759	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801006760	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
644801006761	Protein export membrane protein; Region: SecD_SecF; cl14618
644801006762	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
644801006763	Protein export membrane protein; Region: SecD_SecF; cl14618
644801006764	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
644801006765	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801006766	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801006767	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
644801006768	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
644801006769	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
644801006770	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801006771	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801006772	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801006773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801006774	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
644801006775	putative substrate binding pocket [chemical binding]; other site
644801006776	putative dimerization interface [polypeptide binding]; other site
644801006777	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
644801006778	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
644801006779	putative NAD(P) binding site [chemical binding]; other site
644801006780	short chain dehydrogenase; Provisional; Region: PRK06701
644801006781	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
644801006782	NAD binding site [chemical binding]; other site
644801006783	metal binding site [ion binding]; metal-binding site
644801006784	active site
644801006785	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
644801006786	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
644801006787	putative DNA binding site [nucleotide binding]; other site
644801006788	putative homodimer interface [polypeptide binding]; other site
644801006789	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
644801006790	nucleotide binding site [chemical binding]; other site
644801006791	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
644801006792	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801006793	molybdopterin cofactor binding site; other site
644801006794	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801006795	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801006796	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
644801006797	molybdopterin cofactor binding site; other site
644801006798	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
644801006799	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
644801006800	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
644801006801	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
644801006802	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
644801006803	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
644801006804	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
644801006805	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
644801006806	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
644801006807	active site
644801006808	homodimer interface [polypeptide binding]; other site
644801006809	catalytic site [active]
644801006810	acceptor binding site [chemical binding]; other site
644801006811	trehalose synthase; Region: treS_nterm; TIGR02456
644801006812	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
644801006813	active site
644801006814	catalytic site [active]
644801006815	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
644801006816	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
644801006817	glycogen branching enzyme; Provisional; Region: PRK05402
644801006818	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
644801006819	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
644801006820	active site
644801006821	catalytic site [active]
644801006822	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
644801006823	Predicted integral membrane protein [Function unknown]; Region: COG0392
644801006824	cardiolipin synthase 2; Provisional; Region: PRK11263
644801006825	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
644801006826	putative active site [active]
644801006827	catalytic site [active]
644801006828	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
644801006829	putative active site [active]
644801006830	catalytic site [active]
644801006831	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
644801006832	putative catalytic site [active]
644801006833	putative metal binding site [ion binding]; other site
644801006834	putative phosphate binding site [ion binding]; other site
644801006835	Protein of unknown function DUF72; Region: DUF72; pfam01904
644801006836	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801006837	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801006838	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801006839	putative effector binding pocket; other site
644801006840	dimerization interface [polypeptide binding]; other site
644801006841	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
644801006842	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
644801006843	putative active site [active]
644801006844	metal binding site [ion binding]; metal-binding site
644801006845	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
644801006846	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
644801006847	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
644801006848	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801006849	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
644801006850	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
644801006851	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
644801006852	active site
644801006853	catalytic site [active]
644801006854	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
644801006855	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
644801006856	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
644801006857	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
644801006858	active site
644801006859	catalytic site [active]
644801006860	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
644801006861	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
644801006862	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
644801006863	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
644801006864	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
644801006865	catalytic site [active]
644801006866	active site
644801006867	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
644801006868	glycogen synthase; Provisional; Region: glgA; PRK00654
644801006869	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
644801006870	ADP-binding pocket [chemical binding]; other site
644801006871	homodimer interface [polypeptide binding]; other site
644801006872	Competence-damaged protein; Region: CinA; pfam02464
644801006873	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
644801006874	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801006875	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
644801006876	dinuclear metal binding motif [ion binding]; other site
644801006877	Predicted membrane protein [Function unknown]; Region: COG3205
644801006878	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
644801006879	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
644801006880	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
644801006881	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
644801006882	active site
644801006883	DNA binding site [nucleotide binding]
644801006884	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
644801006885	DNA binding site [nucleotide binding]
644801006886	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
644801006887	nucleotide binding site [chemical binding]; other site
644801006888	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801006889	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801006890	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801006891	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
644801006892	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
644801006893	transcriptional regulator; Provisional; Region: PRK10632
644801006894	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801006895	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801006896	putative effector binding pocket; other site
644801006897	dimerization interface [polypeptide binding]; other site
644801006898	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
644801006899	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
644801006900	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801006901	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801006902	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
644801006903	Fusaric acid resistance protein family; Region: FUSC; pfam04632
644801006904	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
644801006905	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
644801006906	Cupin domain; Region: Cupin_2; cl17218
644801006907	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801006908	replication initiation protein; Region: II; PHA00360
644801006909	Phage replication protein CRI; Region: Phage_CRI; pfam05144
644801006910	Phage X family; Region: Phage_X; cl11585
644801006911	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
644801006912	Zonular occludens toxin (Zot); Region: Zot; cl17485
644801006913	replication initiation protein; Region: II; PHA00360
644801006914	Phage replication protein CRI; Region: Phage_CRI; pfam05144
644801006915	Phage X family; Region: Phage_X; cl11585
644801006916	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
644801006917	Zonular occludens toxin (Zot); Region: Zot; cl17485
644801006918	Phosphopantetheine attachment site; Region: PP-binding; cl09936
644801006919	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
644801006920	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801006921	E3 interaction surface; other site
644801006922	lipoyl attachment site [posttranslational modification]; other site
644801006923	e3 binding domain; Region: E3_binding; pfam02817
644801006924	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
644801006925	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
644801006926	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
644801006927	TPP binding site [chemical binding]; other site
644801006928	alpha subunit interface [polypeptide binding]; other site
644801006929	heterodimer interface [polypeptide binding]; other site
644801006930	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
644801006931	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
644801006932	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
644801006933	tetramer interface [polypeptide binding]; other site
644801006934	TPP-binding site [chemical binding]; other site
644801006935	heterodimer interface [polypeptide binding]; other site
644801006936	phosphorylation loop region [posttranslational modification]
644801006937	acetyl-CoA synthetase; Provisional; Region: PRK04319
644801006938	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
644801006939	acyl-activating enzyme (AAE) consensus motif; other site
644801006940	AMP binding site [chemical binding]; other site
644801006941	active site
644801006942	CoA binding site [chemical binding]; other site
644801006943	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
644801006944	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
644801006945	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801006946	active site
644801006947	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
644801006948	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801006949	ligand binding site [chemical binding]; other site
644801006950	flexible hinge region; other site
644801006951	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
644801006952	putative switch regulator; other site
644801006953	non-specific DNA interactions [nucleotide binding]; other site
644801006954	DNA binding site [nucleotide binding]
644801006955	sequence specific DNA binding site [nucleotide binding]; other site
644801006956	putative cAMP binding site [chemical binding]; other site
644801006957	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
644801006958	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
644801006959	Sulfatase; Region: Sulfatase; pfam00884
644801006960	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
644801006961	BNR repeat-like domain; Region: BNR_2; pfam13088
644801006962	Protein of unknown function (DUF461); Region: DUF461; pfam04314
644801006963	glutathione reductase; Validated; Region: PRK06116
644801006964	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801006965	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801006966	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
644801006967	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801006968	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
644801006969	active site
644801006970	metal binding site [ion binding]; metal-binding site
644801006971	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
644801006972	active site
644801006973	tetramer interface; other site
644801006974	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801006975	dimerization interface [polypeptide binding]; other site
644801006976	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801006977	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801006978	dimer interface [polypeptide binding]; other site
644801006979	putative CheW interface [polypeptide binding]; other site
644801006980	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
644801006981	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801006982	FeS/SAM binding site; other site
644801006983	HemN C-terminal domain; Region: HemN_C; pfam06969
644801006984	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
644801006985	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
644801006986	DEAD_2; Region: DEAD_2; pfam06733
644801006987	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
644801006988	RES domain; Region: RES; pfam08808
644801006989	lysophospholipid transporter LplT; Provisional; Region: PRK11195
644801006990	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
644801006991	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
644801006992	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
644801006993	hypothetical protein; Provisional; Region: PRK02237
644801006994	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
644801006995	active site
644801006996	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
644801006997	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801006998	Low molecular weight phosphatase family; Region: LMWPc; cl00105
644801006999	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
644801007000	active site
644801007001	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801007002	dimerization interface [polypeptide binding]; other site
644801007003	putative DNA binding site [nucleotide binding]; other site
644801007004	putative Zn2+ binding site [ion binding]; other site
644801007005	Low molecular weight phosphatase family; Region: LMWPc; cd00115
644801007006	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
644801007007	active site
644801007008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
644801007009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
644801007010	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
644801007011	arsenical-resistance protein; Region: acr3; TIGR00832
644801007012	Predicted permease; Region: DUF318; cl17795
644801007013	Predicted permease; Region: DUF318; cl17795
644801007014	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
644801007015	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
644801007016	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
644801007017	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
644801007018	GIY-YIG motif/motif A; other site
644801007019	active site
644801007020	catalytic site [active]
644801007021	putative DNA binding site [nucleotide binding]; other site
644801007022	metal binding site [ion binding]; metal-binding site
644801007023	UvrB/uvrC motif; Region: UVR; pfam02151
644801007024	Glutamate-cysteine ligase; Region: GshA; pfam08886
644801007025	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
644801007026	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
644801007027	DNA binding site [nucleotide binding]
644801007028	response regulator; Provisional; Region: PRK09483
644801007029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801007030	active site
644801007031	phosphorylation site [posttranslational modification]
644801007032	intermolecular recognition site; other site
644801007033	dimerization interface [polypeptide binding]; other site
644801007034	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801007035	DNA binding residues [nucleotide binding]
644801007036	dimerization interface [polypeptide binding]; other site
644801007037	Heavy-metal-associated domain; Region: HMA; pfam00403
644801007038	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
644801007039	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
644801007040	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
644801007041	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801007042	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
644801007043	Outer membrane efflux protein; Region: OEP; pfam02321
644801007044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007045	PAS domain; Region: PAS_9; pfam13426
644801007046	putative active site [active]
644801007047	heme pocket [chemical binding]; other site
644801007048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801007049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801007050	dimer interface [polypeptide binding]; other site
644801007051	phosphorylation site [posttranslational modification]
644801007052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801007053	ATP binding site [chemical binding]; other site
644801007054	Mg2+ binding site [ion binding]; other site
644801007055	G-X-G motif; other site
644801007056	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801007057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801007058	active site
644801007059	phosphorylation site [posttranslational modification]
644801007060	intermolecular recognition site; other site
644801007061	dimerization interface [polypeptide binding]; other site
644801007062	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
644801007063	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
644801007064	putative active site [active]
644801007065	metal binding site [ion binding]; metal-binding site
644801007066	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801007067	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
644801007068	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
644801007069	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801007070	FeS/SAM binding site; other site
644801007071	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
644801007072	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
644801007073	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
644801007074	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
644801007075	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
644801007076	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
644801007077	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801007078	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
644801007079	active site
644801007080	FMN binding site [chemical binding]; other site
644801007081	substrate binding site [chemical binding]; other site
644801007082	putative catalytic residue [active]
644801007083	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
644801007084	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
644801007085	NAD(P) binding site [chemical binding]; other site
644801007086	catalytic residues [active]
644801007087	PqqA family; Region: PqqA; pfam08042
644801007088	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
644801007089	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
644801007090	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801007091	FeS/SAM binding site; other site
644801007092	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
644801007093	Predicted membrane protein [Function unknown]; Region: COG3748
644801007094	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
644801007095	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801007096	catalytic residue [active]
644801007097	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
644801007098	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
644801007099	phosphate binding site [ion binding]; other site
644801007100	periplasmic folding chaperone; Provisional; Region: PRK10788
644801007101	SurA N-terminal domain; Region: SurA_N_3; cl07813
644801007102	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
644801007103	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
644801007104	IHF dimer interface [polypeptide binding]; other site
644801007105	IHF - DNA interface [nucleotide binding]; other site
644801007106	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
644801007107	Found in ATP-dependent protease La (LON); Region: LON; smart00464
644801007108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801007109	Walker A motif; other site
644801007110	ATP binding site [chemical binding]; other site
644801007111	Walker B motif; other site
644801007112	arginine finger; other site
644801007113	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
644801007114	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
644801007115	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
644801007116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801007117	Walker A motif; other site
644801007118	ATP binding site [chemical binding]; other site
644801007119	Walker B motif; other site
644801007120	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
644801007121	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
644801007122	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
644801007123	oligomer interface [polypeptide binding]; other site
644801007124	active site residues [active]
644801007125	trigger factor; Provisional; Region: tig; PRK01490
644801007126	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
644801007127	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
644801007128	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
644801007129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
644801007130	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
644801007131	metal ion-dependent adhesion site (MIDAS); other site
644801007132	MoxR-like ATPases [General function prediction only]; Region: COG0714
644801007133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801007134	Walker A motif; other site
644801007135	ATP binding site [chemical binding]; other site
644801007136	Walker B motif; other site
644801007137	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
644801007138	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
644801007139	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
644801007140	Cytochrome c; Region: Cytochrom_C; pfam00034
644801007141	Cytochrome c; Region: Cytochrom_C; pfam00034
644801007142	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
644801007143	rusticyanin; Region: rusti_cyanin; TIGR03095
644801007144	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
644801007145	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
644801007146	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
644801007147	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
644801007148	Transcriptional regulators [Transcription]; Region: FadR; COG2186
644801007149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801007150	DNA-binding site [nucleotide binding]; DNA binding site
644801007151	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
644801007152	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
644801007153	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
644801007154	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
644801007155	homodimer interface [polypeptide binding]; other site
644801007156	NADP binding site [chemical binding]; other site
644801007157	substrate binding site [chemical binding]; other site
644801007158	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
644801007159	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
644801007160	active site
644801007161	HIGH motif; other site
644801007162	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
644801007163	KMSKS motif; other site
644801007164	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
644801007165	tRNA binding surface [nucleotide binding]; other site
644801007166	anticodon binding site; other site
644801007167	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
644801007168	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
644801007169	active site
644801007170	HIGH motif; other site
644801007171	nucleotide binding site [chemical binding]; other site
644801007172	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
644801007173	KMSKS motif; other site
644801007174	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
644801007175	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
644801007176	substrate binding site [chemical binding]; other site
644801007177	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
644801007178	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
644801007179	putative active site [active]
644801007180	putative metal binding site [ion binding]; other site
644801007181	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
644801007182	active site
644801007183	dinuclear metal binding site [ion binding]; other site
644801007184	dimerization interface [polypeptide binding]; other site
644801007185	universal stress protein UspE; Provisional; Region: PRK11175
644801007186	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801007187	Ligand Binding Site [chemical binding]; other site
644801007188	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801007189	Ligand Binding Site [chemical binding]; other site
644801007190	Predicted Fe-S protein [General function prediction only]; Region: COG3313
644801007191	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
644801007192	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
644801007193	substrate binding site [chemical binding]; other site
644801007194	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
644801007195	substrate binding site [chemical binding]; other site
644801007196	ligand binding site [chemical binding]; other site
644801007197	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
644801007198	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801007199	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801007200	ligand binding site [chemical binding]; other site
644801007201	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
644801007202	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801007203	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801007204	DNA binding residues [nucleotide binding]
644801007205	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801007206	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
644801007207	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
644801007208	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
644801007209	Cl binding site [ion binding]; other site
644801007210	oligomer interface [polypeptide binding]; other site
644801007211	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
644801007212	phosphoenolpyruvate synthase; Validated; Region: PRK06464
644801007213	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
644801007214	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
644801007215	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
644801007216	PEP synthetase regulatory protein; Provisional; Region: PRK05339
644801007217	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
644801007218	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
644801007219	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
644801007220	substrate binding site [chemical binding]; other site
644801007221	ligand binding site [chemical binding]; other site
644801007222	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
644801007223	substrate binding site [chemical binding]; other site
644801007224	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
644801007225	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
644801007226	dimer interface [polypeptide binding]; other site
644801007227	active site
644801007228	citrylCoA binding site [chemical binding]; other site
644801007229	oxalacetate/citrate binding site [chemical binding]; other site
644801007230	coenzyme A binding site [chemical binding]; other site
644801007231	catalytic triad [active]
644801007232	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
644801007233	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
644801007234	tetramer interface [polypeptide binding]; other site
644801007235	active site
644801007236	Mg2+/Mn2+ binding site [ion binding]; other site
644801007237	Transcriptional regulators [Transcription]; Region: GntR; COG1802
644801007238	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801007239	DNA-binding site [nucleotide binding]; DNA binding site
644801007240	FCD domain; Region: FCD; pfam07729
644801007241	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
644801007242	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
644801007243	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
644801007244	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
644801007245	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
644801007246	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
644801007247	chorismate binding enzyme; Region: Chorismate_bind; cl10555
644801007248	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
644801007249	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
644801007250	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
644801007251	Active Sites [active]
644801007252	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
644801007253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801007254	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
644801007255	substrate binding site [chemical binding]; other site
644801007256	dimerization interface [polypeptide binding]; other site
644801007257	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
644801007258	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
644801007259	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
644801007260	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
644801007261	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
644801007262	Predicted acetyltransferase [General function prediction only]; Region: COG2388
644801007263	L,D-transpeptidase; Provisional; Region: PRK10260
644801007264	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
644801007265	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
644801007266	active site
644801007267	catalytic triad [active]
644801007268	oxyanion hole [active]
644801007269	switch loop; other site
644801007270	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
644801007271	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
644801007272	Walker A/P-loop; other site
644801007273	ATP binding site [chemical binding]; other site
644801007274	Q-loop/lid; other site
644801007275	ABC transporter signature motif; other site
644801007276	Walker B; other site
644801007277	D-loop; other site
644801007278	H-loop/switch region; other site
644801007279	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
644801007280	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
644801007281	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
644801007282	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
644801007283	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
644801007284	lipase chaperone; Provisional; Region: PRK01294
644801007285	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
644801007286	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
644801007287	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801007288	substrate binding pocket [chemical binding]; other site
644801007289	membrane-bound complex binding site; other site
644801007290	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
644801007291	hinge residues; other site
644801007292	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801007293	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801007294	catalytic residue [active]
644801007295	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
644801007296	active site
644801007297	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
644801007298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801007299	dimerization interface [polypeptide binding]; other site
644801007300	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801007301	dimer interface [polypeptide binding]; other site
644801007302	putative CheW interface [polypeptide binding]; other site
644801007303	ykkC-yxkD leader; Psest_2345
644801007304	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801007305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801007306	dimer interface [polypeptide binding]; other site
644801007307	conserved gate region; other site
644801007308	putative PBP binding loops; other site
644801007309	ABC-ATPase subunit interface; other site
644801007310	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
644801007311	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
644801007312	Walker A/P-loop; other site
644801007313	ATP binding site [chemical binding]; other site
644801007314	Q-loop/lid; other site
644801007315	ABC transporter signature motif; other site
644801007316	Walker B; other site
644801007317	D-loop; other site
644801007318	H-loop/switch region; other site
644801007319	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
644801007320	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
644801007321	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
644801007322	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
644801007323	mini-ykkC RNA motif; Psest_2350
644801007324	urea carboxylase; Region: urea_carbox; TIGR02712
644801007325	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
644801007326	ATP-grasp domain; Region: ATP-grasp_4; cl17255
644801007327	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
644801007328	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
644801007329	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
644801007330	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
644801007331	carboxyltransferase (CT) interaction site; other site
644801007332	biotinylation site [posttranslational modification]; other site
644801007333	allophanate hydrolase; Provisional; Region: PRK08186
644801007334	Amidase; Region: Amidase; cl11426
644801007335	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
644801007336	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
644801007337	active site
644801007338	catalytic tetrad [active]
644801007339	ykkC-yxkD leader; Psest_2354
644801007340	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801007341	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
644801007342	Fatty acid desaturase; Region: FA_desaturase; pfam00487
644801007343	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
644801007344	putative di-iron ligands [ion binding]; other site
644801007345	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
644801007346	classical (c) SDRs; Region: SDR_c; cd05233
644801007347	NAD(P) binding site [chemical binding]; other site
644801007348	active site
644801007349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801007350	NAD(P) binding site [chemical binding]; other site
644801007351	active site
644801007352	Creatinine amidohydrolase; Region: Creatininase; pfam02633
644801007353	Isochorismatase family; Region: Isochorismatase; pfam00857
644801007354	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
644801007355	catalytic triad [active]
644801007356	conserved cis-peptide bond; other site
644801007357	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
644801007358	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801007359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801007360	dimer interface [polypeptide binding]; other site
644801007361	conserved gate region; other site
644801007362	putative PBP binding loops; other site
644801007363	ABC-ATPase subunit interface; other site
644801007364	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
644801007365	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
644801007366	Walker A/P-loop; other site
644801007367	ATP binding site [chemical binding]; other site
644801007368	Q-loop/lid; other site
644801007369	ABC transporter signature motif; other site
644801007370	Walker B; other site
644801007371	D-loop; other site
644801007372	H-loop/switch region; other site
644801007373	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
644801007374	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
644801007375	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
644801007376	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
644801007377	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801007378	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
644801007379	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
644801007380	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801007381	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
644801007382	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
644801007383	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
644801007384	YccA-like proteins; Region: YccA_like; cd10433
644801007385	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
644801007386	sulfur relay protein TusC; Validated; Region: PRK00211
644801007387	DsrH like protein; Region: DsrH; cl17347
644801007388	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
644801007389	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
644801007390	hypothetical protein; Validated; Region: PRK09071
644801007391	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
644801007392	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
644801007393	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
644801007394	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
644801007395	putative dimer interface [polypeptide binding]; other site
644801007396	N-terminal domain interface [polypeptide binding]; other site
644801007397	putative substrate binding pocket (H-site) [chemical binding]; other site
644801007398	PAS fold; Region: PAS_7; pfam12860
644801007399	PAS fold; Region: PAS_7; pfam12860
644801007400	PAS domain S-box; Region: sensory_box; TIGR00229
644801007401	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007402	putative active site [active]
644801007403	heme pocket [chemical binding]; other site
644801007404	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801007405	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801007406	dimer interface [polypeptide binding]; other site
644801007407	phosphorylation site [posttranslational modification]
644801007408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801007409	ATP binding site [chemical binding]; other site
644801007410	Mg2+ binding site [ion binding]; other site
644801007411	G-X-G motif; other site
644801007412	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801007413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801007414	active site
644801007415	phosphorylation site [posttranslational modification]
644801007416	intermolecular recognition site; other site
644801007417	dimerization interface [polypeptide binding]; other site
644801007418	Uncharacterized conserved protein [Function unknown]; Region: COG3287
644801007419	FIST N domain; Region: FIST; pfam08495
644801007420	FIST C domain; Region: FIST_C; pfam10442
644801007421	Gram-negative porin; Region: Porin_4; pfam13609
644801007422	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
644801007423	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
644801007424	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
644801007425	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
644801007426	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
644801007427	DNA binding residues [nucleotide binding]
644801007428	B12 binding domain; Region: B12-binding_2; pfam02607
644801007429	Protein of unknown function, DUF393; Region: DUF393; pfam04134
644801007430	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
644801007431	homodecamer interface [polypeptide binding]; other site
644801007432	GTP cyclohydrolase I; Provisional; Region: PLN03044
644801007433	active site
644801007434	putative catalytic site residues [active]
644801007435	zinc binding site [ion binding]; other site
644801007436	GTP-CH-I/GFRP interaction surface; other site
644801007437	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
644801007438	homooctamer interface [polypeptide binding]; other site
644801007439	active site
644801007440	MFS/sugar transport protein; Region: MFS_2; pfam13347
644801007441	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
644801007442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007443	PAS domain; Region: PAS_9; pfam13426
644801007444	putative active site [active]
644801007445	heme pocket [chemical binding]; other site
644801007446	PAS fold; Region: PAS_4; pfam08448
644801007447	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007448	putative active site [active]
644801007449	heme pocket [chemical binding]; other site
644801007450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007451	PAS domain; Region: PAS_9; pfam13426
644801007452	putative active site [active]
644801007453	heme pocket [chemical binding]; other site
644801007454	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801007455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801007456	metal binding site [ion binding]; metal-binding site
644801007457	active site
644801007458	I-site; other site
644801007459	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801007460	ferrochelatase; Reviewed; Region: hemH; PRK00035
644801007461	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
644801007462	C-terminal domain interface [polypeptide binding]; other site
644801007463	active site
644801007464	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
644801007465	active site
644801007466	N-terminal domain interface [polypeptide binding]; other site
644801007467	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
644801007468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801007469	NAD(P) binding site [chemical binding]; other site
644801007470	active site
644801007471	Protein of unknown function (DUF523); Region: DUF523; pfam04463
644801007472	Uncharacterized conserved protein [Function unknown]; Region: COG3272
644801007473	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
644801007474	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
644801007475	DNA binding residues [nucleotide binding]
644801007476	B12 binding domain; Region: B12-binding_2; pfam02607
644801007477	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
644801007478	DNA photolyase; Region: DNA_photolyase; pfam00875
644801007479	SnoaL-like domain; Region: SnoaL_2; pfam12680
644801007480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801007481	short chain dehydrogenase; Provisional; Region: PRK07023
644801007482	NAD(P) binding site [chemical binding]; other site
644801007483	active site
644801007484	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
644801007485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801007486	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
644801007487	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
644801007488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801007489	S-adenosylmethionine binding site [chemical binding]; other site
644801007490	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801007491	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801007492	dimer interface [polypeptide binding]; other site
644801007493	putative CheW interface [polypeptide binding]; other site
644801007494	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
644801007495	NAD-dependent deacetylase; Provisional; Region: PRK00481
644801007496	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
644801007497	NAD+ binding site [chemical binding]; other site
644801007498	substrate binding site [chemical binding]; other site
644801007499	Zn binding site [ion binding]; other site
644801007500	nitrite reductase subunit NirD; Provisional; Region: PRK14989
644801007501	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801007502	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
644801007503	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
644801007504	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
644801007505	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
644801007506	Protein phosphatase 2C; Region: PP2C; pfam00481
644801007507	active site
644801007508	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
644801007509	Catalytic domain of Protein Kinases; Region: PKc; cd00180
644801007510	active site
644801007511	ATP binding site [chemical binding]; other site
644801007512	substrate binding site [chemical binding]; other site
644801007513	activation loop (A-loop); other site
644801007514	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
644801007515	Family description; Region: UvrD_C_2; pfam13538
644801007516	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
644801007517	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
644801007518	GAF domain; Region: GAF; pfam01590
644801007519	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
644801007520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801007521	dimer interface [polypeptide binding]; other site
644801007522	phosphorylation site [posttranslational modification]
644801007523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801007524	ATP binding site [chemical binding]; other site
644801007525	G-X-G motif; other site
644801007526	Response regulator receiver domain; Region: Response_reg; pfam00072
644801007527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801007528	active site
644801007529	phosphorylation site [posttranslational modification]
644801007530	intermolecular recognition site; other site
644801007531	dimerization interface [polypeptide binding]; other site
644801007532	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
644801007533	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
644801007534	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
644801007535	TolR protein; Region: tolR; TIGR02801
644801007536	TolQ protein; Region: tolQ; TIGR02796
644801007537	Phytase; Region: Phytase; cl17685
644801007538	Phytase; Region: Phytase; cl17685
644801007539	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
644801007540	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
644801007541	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801007542	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801007543	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801007544	metal binding site [ion binding]; metal-binding site
644801007545	active site
644801007546	I-site; other site
644801007547	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
644801007548	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801007549	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801007550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801007551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801007552	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
644801007553	dimerization interface [polypeptide binding]; other site
644801007554	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
644801007555	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
644801007556	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
644801007557	putative molybdopterin cofactor binding site [chemical binding]; other site
644801007558	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
644801007559	putative molybdopterin cofactor binding site; other site
644801007560	Uncharacterized conserved protein [Function unknown]; Region: COG3791
644801007561	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
644801007562	TrkA-N domain; Region: TrkA_N; pfam02254
644801007563	TrkA-C domain; Region: TrkA_C; pfam02080
644801007564	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
644801007565	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
644801007566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007567	PAS fold; Region: PAS_3; pfam08447
644801007568	putative active site [active]
644801007569	heme pocket [chemical binding]; other site
644801007570	PAS domain S-box; Region: sensory_box; TIGR00229
644801007571	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007572	putative active site [active]
644801007573	heme pocket [chemical binding]; other site
644801007574	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801007575	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801007576	dimer interface [polypeptide binding]; other site
644801007577	phosphorylation site [posttranslational modification]
644801007578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801007579	ATP binding site [chemical binding]; other site
644801007580	Mg2+ binding site [ion binding]; other site
644801007581	G-X-G motif; other site
644801007582	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801007583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801007584	active site
644801007585	phosphorylation site [posttranslational modification]
644801007586	intermolecular recognition site; other site
644801007587	dimerization interface [polypeptide binding]; other site
644801007588	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
644801007589	Bacterial SH3 domain; Region: SH3_3; pfam08239
644801007590	AzlC protein; Region: AzlC; pfam03591
644801007591	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
644801007592	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801007593	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801007594	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
644801007595	Transglycosylase; Region: Transgly; pfam00912
644801007596	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
644801007597	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
644801007598	putative catalytic site [active]
644801007599	putative phosphate binding site [ion binding]; other site
644801007600	putative metal binding site [ion binding]; other site
644801007601	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
644801007602	putative homodimer interface [polypeptide binding]; other site
644801007603	putative active site pocket [active]
644801007604	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
644801007605	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
644801007606	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801007607	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801007608	LysR substrate binding domain; Region: LysR_substrate; pfam03466
644801007609	dimerization interface [polypeptide binding]; other site
644801007610	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
644801007611	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
644801007612	tetrameric interface [polypeptide binding]; other site
644801007613	NAD binding site [chemical binding]; other site
644801007614	catalytic residues [active]
644801007615	enoyl-CoA hydratase; Provisional; Region: PRK05862
644801007616	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801007617	substrate binding site [chemical binding]; other site
644801007618	oxyanion hole (OAH) forming residues; other site
644801007619	trimer interface [polypeptide binding]; other site
644801007620	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
644801007621	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
644801007622	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
644801007623	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801007624	substrate binding site [chemical binding]; other site
644801007625	oxyanion hole (OAH) forming residues; other site
644801007626	trimer interface [polypeptide binding]; other site
644801007627	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
644801007628	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801007629	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801007630	active site
644801007631	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
644801007632	CoA-transferase family III; Region: CoA_transf_3; pfam02515
644801007633	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
644801007634	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
644801007635	dimer interface [polypeptide binding]; other site
644801007636	acyl-activating enzyme (AAE) consensus motif; other site
644801007637	putative active site [active]
644801007638	AMP binding site [chemical binding]; other site
644801007639	putative CoA binding site [chemical binding]; other site
644801007640	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801007641	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801007642	active site
644801007643	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
644801007644	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
644801007645	dimer interface [polypeptide binding]; other site
644801007646	active site
644801007647	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801007648	NAD(P) binding site [chemical binding]; other site
644801007649	active site
644801007650	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
644801007651	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801007652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801007653	Predicted membrane protein [Function unknown]; Region: COG1238
644801007654	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
644801007655	catalytic residues [active]
644801007656	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
644801007657	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
644801007658	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
644801007659	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
644801007660	active site residue [active]
644801007661	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
644801007662	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
644801007663	active site
644801007664	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
644801007665	active site 2 [active]
644801007666	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
644801007667	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
644801007668	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
644801007669	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
644801007670	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
644801007671	Protein of unknown function DUF58; Region: DUF58; pfam01882
644801007672	MoxR-like ATPases [General function prediction only]; Region: COG0714
644801007673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801007674	Walker A motif; other site
644801007675	ATP binding site [chemical binding]; other site
644801007676	Walker B motif; other site
644801007677	arginine finger; other site
644801007678	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
644801007679	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
644801007680	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801007681	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
644801007682	Soluble P-type ATPase [General function prediction only]; Region: COG4087
644801007683	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
644801007684	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
644801007685	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
644801007686	active site residue [active]
644801007687	selenophosphate synthetase; Provisional; Region: PRK00943
644801007688	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
644801007689	dimerization interface [polypeptide binding]; other site
644801007690	putative ATP binding site [chemical binding]; other site
644801007691	hypothetical protein; Provisional; Region: PRK10279
644801007692	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
644801007693	active site
644801007694	nucleophile elbow; other site
644801007695	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
644801007696	Domain of unknown function DUF20; Region: UPF0118; pfam01594
644801007697	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
644801007698	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
644801007699	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
644801007700	CoenzymeA binding site [chemical binding]; other site
644801007701	subunit interaction site [polypeptide binding]; other site
644801007702	PHB binding site; other site
644801007703	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
644801007704	catalytic core [active]
644801007705	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
644801007706	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
644801007707	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
644801007708	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
644801007709	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
644801007710	active site 1 [active]
644801007711	dimer interface [polypeptide binding]; other site
644801007712	active site 2 [active]
644801007713	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
644801007714	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
644801007715	dimer interface [polypeptide binding]; other site
644801007716	active site
644801007717	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
644801007718	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801007719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801007720	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801007721	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801007722	active site
644801007723	beta-ketothiolase; Provisional; Region: PRK09051
644801007724	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
644801007725	dimer interface [polypeptide binding]; other site
644801007726	active site
644801007727	acyl-CoA synthetase; Validated; Region: PRK08316
644801007728	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
644801007729	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
644801007730	acyl-activating enzyme (AAE) consensus motif; other site
644801007731	acyl-activating enzyme (AAE) consensus motif; other site
644801007732	putative AMP binding site [chemical binding]; other site
644801007733	putative active site [active]
644801007734	putative CoA binding site [chemical binding]; other site
644801007735	serine/threonine transporter SstT; Provisional; Region: PRK13628
644801007736	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
644801007737	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
644801007738	HAMP domain; Region: HAMP; pfam00672
644801007739	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801007740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801007741	dimer interface [polypeptide binding]; other site
644801007742	putative CheW interface [polypeptide binding]; other site
644801007743	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
644801007744	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
644801007745	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801007746	dimerization interface [polypeptide binding]; other site
644801007747	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801007748	dimer interface [polypeptide binding]; other site
644801007749	putative CheW interface [polypeptide binding]; other site
644801007750	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
644801007751	Amidohydrolase; Region: Amidohydro_2; pfam04909
644801007752	OsmC-like protein; Region: OsmC; pfam02566
644801007753	heat shock protein 90; Provisional; Region: PRK05218
644801007754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801007755	ATP binding site [chemical binding]; other site
644801007756	Mg2+ binding site [ion binding]; other site
644801007757	G-X-G motif; other site
644801007758	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
644801007759	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
644801007760	CoenzymeA binding site [chemical binding]; other site
644801007761	subunit interaction site [polypeptide binding]; other site
644801007762	PHB binding site; other site
644801007763	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
644801007764	CoenzymeA binding site [chemical binding]; other site
644801007765	subunit interaction site [polypeptide binding]; other site
644801007766	PHB binding site; other site
644801007767	Predicted membrane protein [Function unknown]; Region: COG3821
644801007768	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
644801007769	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
644801007770	CoA binding domain; Region: CoA_binding; smart00881
644801007771	CoA-ligase; Region: Ligase_CoA; pfam00549
644801007772	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
644801007773	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
644801007774	CoA-ligase; Region: Ligase_CoA; pfam00549
644801007775	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
644801007776	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
644801007777	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801007778	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
644801007779	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
644801007780	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
644801007781	E3 interaction surface; other site
644801007782	lipoyl attachment site [posttranslational modification]; other site
644801007783	e3 binding domain; Region: E3_binding; pfam02817
644801007784	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
644801007785	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
644801007786	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
644801007787	TPP-binding site [chemical binding]; other site
644801007788	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
644801007789	PYR/PP interface [polypeptide binding]; other site
644801007790	dimer interface [polypeptide binding]; other site
644801007791	TPP binding site [chemical binding]; other site
644801007792	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
644801007793	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
644801007794	L-aspartate oxidase; Provisional; Region: PRK06175
644801007795	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
644801007796	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
644801007797	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
644801007798	SdhC subunit interface [polypeptide binding]; other site
644801007799	proximal heme binding site [chemical binding]; other site
644801007800	cardiolipin binding site; other site
644801007801	Iron-sulfur protein interface; other site
644801007802	proximal quinone binding site [chemical binding]; other site
644801007803	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
644801007804	Iron-sulfur protein interface; other site
644801007805	proximal quinone binding site [chemical binding]; other site
644801007806	SdhD (CybS) interface [polypeptide binding]; other site
644801007807	proximal heme binding site [chemical binding]; other site
644801007808	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
644801007809	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
644801007810	dimer interface [polypeptide binding]; other site
644801007811	active site
644801007812	citrylCoA binding site [chemical binding]; other site
644801007813	NADH binding [chemical binding]; other site
644801007814	cationic pore residues; other site
644801007815	oxalacetate/citrate binding site [chemical binding]; other site
644801007816	coenzyme A binding site [chemical binding]; other site
644801007817	catalytic triad [active]
644801007818	Protein of unknown function, DUF486; Region: DUF486; pfam04342
644801007819	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
644801007820	flagellar protein FliS; Validated; Region: fliS; PRK05685
644801007821	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
644801007822	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
644801007823	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
644801007824	FlaG protein; Region: FlaG; pfam03646
644801007825	flagellin; Reviewed; Region: PRK08869
644801007826	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
644801007827	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
644801007828	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
644801007829	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
644801007830	nucleotide binding pocket [chemical binding]; other site
644801007831	K-X-D-G motif; other site
644801007832	catalytic site [active]
644801007833	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
644801007834	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
644801007835	Dimer interface [polypeptide binding]; other site
644801007836	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
644801007837	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
644801007838	FtsZ protein binding site [polypeptide binding]; other site
644801007839	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
644801007840	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
644801007841	Walker A/P-loop; other site
644801007842	ATP binding site [chemical binding]; other site
644801007843	Q-loop/lid; other site
644801007844	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
644801007845	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
644801007846	ABC transporter signature motif; other site
644801007847	Walker B; other site
644801007848	D-loop; other site
644801007849	H-loop/switch region; other site
644801007850	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
644801007851	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801007852	FeS/SAM binding site; other site
644801007853	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
644801007854	Ion transport protein; Region: Ion_trans; pfam00520
644801007855	Ion channel; Region: Ion_trans_2; pfam07885
644801007856	Double zinc ribbon; Region: DZR; pfam12773
644801007857	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
644801007858	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
644801007859	Predicted membrane protein [Function unknown]; Region: COG4244
644801007860	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
644801007861	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
644801007862	Cytochrome c; Region: Cytochrom_C; pfam00034
644801007863	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
644801007864	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
644801007865	D-pathway; other site
644801007866	Putative ubiquinol binding site [chemical binding]; other site
644801007867	Low-spin heme (heme b) binding site [chemical binding]; other site
644801007868	Putative water exit pathway; other site
644801007869	Binuclear center (heme o3/CuB) [ion binding]; other site
644801007870	K-pathway; other site
644801007871	Putative proton exit pathway; other site
644801007872	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
644801007873	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
644801007874	CPxP  motif; other site
644801007875	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
644801007876	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
644801007877	aconitate hydratase; Validated; Region: PRK09277
644801007878	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
644801007879	substrate binding site [chemical binding]; other site
644801007880	ligand binding site [chemical binding]; other site
644801007881	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
644801007882	substrate binding site [chemical binding]; other site
644801007883	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801007884	PAS domain; Region: PAS_9; pfam13426
644801007885	putative active site [active]
644801007886	heme pocket [chemical binding]; other site
644801007887	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801007888	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801007889	dimer interface [polypeptide binding]; other site
644801007890	putative CheW interface [polypeptide binding]; other site
644801007891	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
644801007892	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
644801007893	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
644801007894	Low-spin heme binding site [chemical binding]; other site
644801007895	Putative water exit pathway; other site
644801007896	Binuclear center (active site) [active]
644801007897	Putative proton exit pathway; other site
644801007898	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
644801007899	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
644801007900	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
644801007901	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801007902	Cytochrome c; Region: Cytochrom_C; pfam00034
644801007903	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
644801007904	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
644801007905	Low-spin heme binding site [chemical binding]; other site
644801007906	Putative water exit pathway; other site
644801007907	Binuclear center (active site) [active]
644801007908	Putative proton exit pathway; other site
644801007909	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
644801007910	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
644801007911	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
644801007912	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
644801007913	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801007914	Cytochrome c; Region: Cytochrom_C; pfam00034
644801007915	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
644801007916	4Fe-4S binding domain; Region: Fer4_5; pfam12801
644801007917	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
644801007918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
644801007919	FixH; Region: FixH; pfam05751
644801007920	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
644801007921	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
644801007922	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
644801007923	metal-binding site [ion binding]
644801007924	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
644801007925	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
644801007926	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
644801007927	Uncharacterized conserved protein [Function unknown]; Region: COG2836
644801007928	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
644801007929	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
644801007930	homodimer interface [polypeptide binding]; other site
644801007931	NAD binding pocket [chemical binding]; other site
644801007932	ATP binding pocket [chemical binding]; other site
644801007933	Mg binding site [ion binding]; other site
644801007934	active-site loop [active]
644801007935	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
644801007936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801007937	FeS/SAM binding site; other site
644801007938	HemN C-terminal domain; Region: HemN_C; pfam06969
644801007939	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
644801007940	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801007941	ligand binding site [chemical binding]; other site
644801007942	flexible hinge region; other site
644801007943	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
644801007944	putative switch regulator; other site
644801007945	non-specific DNA interactions [nucleotide binding]; other site
644801007946	DNA binding site [nucleotide binding]
644801007947	sequence specific DNA binding site [nucleotide binding]; other site
644801007948	putative cAMP binding site [chemical binding]; other site
644801007949	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801007950	active site
644801007951	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
644801007952	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
644801007953	Cu(I) binding site [ion binding]; other site
644801007954	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801007955	membrane-bound complex binding site; other site
644801007956	hinge residues; other site
644801007957	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801007958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801007959	dimer interface [polypeptide binding]; other site
644801007960	conserved gate region; other site
644801007961	putative PBP binding loops; other site
644801007962	ABC-ATPase subunit interface; other site
644801007963	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
644801007964	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
644801007965	Walker A/P-loop; other site
644801007966	ATP binding site [chemical binding]; other site
644801007967	Q-loop/lid; other site
644801007968	ABC transporter signature motif; other site
644801007969	Walker B; other site
644801007970	D-loop; other site
644801007971	H-loop/switch region; other site
644801007972	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
644801007973	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801007974	substrate binding pocket [chemical binding]; other site
644801007975	membrane-bound complex binding site; other site
644801007976	hinge residues; other site
644801007977	recombination protein RecR; Reviewed; Region: recR; PRK00076
644801007978	RecR protein; Region: RecR; pfam02132
644801007979	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
644801007980	putative active site [active]
644801007981	putative metal-binding site [ion binding]; other site
644801007982	tetramer interface [polypeptide binding]; other site
644801007983	hypothetical protein; Validated; Region: PRK00153
644801007984	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
644801007985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801007986	Walker A motif; other site
644801007987	ATP binding site [chemical binding]; other site
644801007988	Walker B motif; other site
644801007989	arginine finger; other site
644801007990	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
644801007991	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
644801007992	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
644801007993	ligand binding site [chemical binding]; other site
644801007994	NAD binding site [chemical binding]; other site
644801007995	catalytic site [active]
644801007996	homodimer interface [polypeptide binding]; other site
644801007997	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
644801007998	multidrug efflux protein; Reviewed; Region: PRK01766
644801007999	cation binding site [ion binding]; other site
644801008000	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801008001	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801008002	ligand binding site [chemical binding]; other site
644801008003	flexible hinge region; other site
644801008004	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801008005	active site residue [active]
644801008006	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
644801008007	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
644801008008	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801008009	catalytic residue [active]
644801008010	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
644801008011	SnoaL-like domain; Region: SnoaL_2; pfam12680
644801008012	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801008013	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
644801008014	active site
644801008015	FMN binding site [chemical binding]; other site
644801008016	2,4-decadienoyl-CoA binding site; other site
644801008017	catalytic residue [active]
644801008018	4Fe-4S cluster binding site [ion binding]; other site
644801008019	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
644801008020	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
644801008021	active site
644801008022	catalytic triad [active]
644801008023	dimer interface [polypeptide binding]; other site
644801008024	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
644801008025	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801008026	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801008027	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
644801008028	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
644801008029	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
644801008030	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
644801008031	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
644801008032	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
644801008033	active site
644801008034	Zn binding site [ion binding]; other site
644801008035	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
644801008036	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801008037	putative active site [active]
644801008038	heme pocket [chemical binding]; other site
644801008039	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801008040	putative active site [active]
644801008041	heme pocket [chemical binding]; other site
644801008042	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801008043	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801008044	metal binding site [ion binding]; metal-binding site
644801008045	active site
644801008046	I-site; other site
644801008047	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801008048	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
644801008049	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801008050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008052	dimerization interface [polypeptide binding]; other site
644801008053	LysR substrate binding domain; Region: LysR_substrate; pfam03466
644801008054	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
644801008055	dimer interface [polypeptide binding]; other site
644801008056	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
644801008057	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
644801008058	tetramer interface [polypeptide binding]; other site
644801008059	active site
644801008060	Mg2+/Mn2+ binding site [ion binding]; other site
644801008061	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008063	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
644801008064	putative effector binding pocket; other site
644801008065	putative dimerization interface [polypeptide binding]; other site
644801008066	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
644801008067	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008068	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801008069	dimerization interface [polypeptide binding]; other site
644801008070	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
644801008071	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
644801008072	putative C-terminal domain interface [polypeptide binding]; other site
644801008073	putative GSH binding site (G-site) [chemical binding]; other site
644801008074	putative dimer interface [polypeptide binding]; other site
644801008075	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
644801008076	putative N-terminal domain interface [polypeptide binding]; other site
644801008077	putative dimer interface [polypeptide binding]; other site
644801008078	putative substrate binding pocket (H-site) [chemical binding]; other site
644801008079	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
644801008080	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
644801008081	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
644801008082	type II secretion system protein D; Region: type_II_gspD; TIGR02517
644801008083	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
644801008084	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
644801008085	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
644801008086	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
644801008087	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
644801008088	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
644801008089	homodimer interface [polypeptide binding]; other site
644801008090	substrate-cofactor binding pocket; other site
644801008091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801008092	catalytic residue [active]
644801008093	amidophosphoribosyltransferase; Provisional; Region: PRK09246
644801008094	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
644801008095	active site
644801008096	tetramer interface [polypeptide binding]; other site
644801008097	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801008098	active site
644801008099	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
644801008100	Colicin V production protein; Region: Colicin_V; cl00567
644801008101	Sporulation related domain; Region: SPOR; pfam05036
644801008102	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
644801008103	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
644801008104	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
644801008105	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
644801008106	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
644801008107	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
644801008108	active site
644801008109	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
644801008110	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
644801008111	dimerization interface 3.5A [polypeptide binding]; other site
644801008112	active site
644801008113	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
644801008114	FimV N-terminal domain; Region: FimV_core; TIGR03505
644801008115	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
644801008116	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
644801008117	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
644801008118	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
644801008119	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
644801008120	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
644801008121	tartrate dehydrogenase; Region: TTC; TIGR02089
644801008122	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
644801008123	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
644801008124	substrate binding site [chemical binding]; other site
644801008125	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
644801008126	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
644801008127	substrate binding site [chemical binding]; other site
644801008128	ligand binding site [chemical binding]; other site
644801008129	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008130	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008131	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
644801008132	dimerization interface [polypeptide binding]; other site
644801008133	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
644801008134	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
644801008135	putative dimer interface [polypeptide binding]; other site
644801008136	short chain dehydrogenase; Provisional; Region: PRK06123
644801008137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801008138	NAD(P) binding site [chemical binding]; other site
644801008139	active site
644801008140	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
644801008141	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
644801008142	FMN binding site [chemical binding]; other site
644801008143	active site
644801008144	catalytic residues [active]
644801008145	substrate binding site [chemical binding]; other site
644801008146	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
644801008147	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
644801008148	inhibitor-cofactor binding pocket; inhibition site
644801008149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801008150	catalytic residue [active]
644801008151	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
644801008152	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
644801008153	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
644801008154	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
644801008155	active site
644801008156	tyrosine kinase; Provisional; Region: PRK11519
644801008157	Chain length determinant protein; Region: Wzz; pfam02706
644801008158	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
644801008159	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
644801008160	WbqC-like protein family; Region: WbqC; pfam08889
644801008161	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
644801008162	transcriptional activator RfaH; Region: RfaH; TIGR01955
644801008163	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
644801008164	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801008165	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
644801008166	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801008167	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
644801008168	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801008169	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
644801008170	putative ADP-binding pocket [chemical binding]; other site
644801008171	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
644801008172	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
644801008173	active site
644801008174	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
644801008175	Tetratricopeptide repeat; Region: TPR_16; pfam13432
644801008176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801008177	binding surface
644801008178	TPR motif; other site
644801008179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801008180	binding surface
644801008181	TPR repeat; Region: TPR_11; pfam13414
644801008182	TPR motif; other site
644801008183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801008184	binding surface
644801008185	TPR motif; other site
644801008186	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
644801008187	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
644801008188	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
644801008189	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
644801008190	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
644801008191	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
644801008192	ATP binding site [chemical binding]; other site
644801008193	Walker A motif; other site
644801008194	hexamer interface [polypeptide binding]; other site
644801008195	Walker B motif; other site
644801008196	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
644801008197	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
644801008198	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
644801008199	TadE-like protein; Region: TadE; pfam07811
644801008200	TadE-like protein; Region: TadE; pfam07811
644801008201	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
644801008202	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
644801008203	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
644801008204	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
644801008205	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
644801008206	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
644801008207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
644801008208	Walker A motif; other site
644801008209	ATP binding site [chemical binding]; other site
644801008210	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
644801008211	Flp/Fap pilin component; Region: Flp_Fap; cl01585
644801008212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
644801008213	intermolecular recognition site; other site
644801008214	active site
644801008215	dimerization interface [polypeptide binding]; other site
644801008216	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801008217	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801008218	Helix-turn-helix domain; Region: HTH_18; pfam12833
644801008219	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
644801008220	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
644801008221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801008222	FeS/SAM binding site; other site
644801008223	TRAM domain; Region: TRAM; cl01282
644801008224	choline dehydrogenase; Validated; Region: PRK02106
644801008225	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
644801008226	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
644801008227	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
644801008228	NAD(P) binding site [chemical binding]; other site
644801008229	catalytic residues [active]
644801008230	choline transport protein BetT; Provisional; Region: PRK09928
644801008231	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
644801008232	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
644801008233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801008234	catalytic residue [active]
644801008235	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
644801008236	homodimer interaction site [polypeptide binding]; other site
644801008237	cofactor binding site; other site
644801008238	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
644801008239	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
644801008240	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
644801008241	active site
644801008242	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
644801008243	SEC-C motif; Region: SEC-C; pfam02810
644801008244	LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608
644801008245	Water Stress and Hypersensitive response; Region: WHy; smart00769
644801008246	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
644801008247	beta-hexosaminidase; Provisional; Region: PRK05337
644801008248	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
644801008249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
644801008250	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
644801008251	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801008252	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801008253	LexA repressor; Validated; Region: PRK00215
644801008254	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
644801008255	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
644801008256	Catalytic site [active]
644801008257	Cell division inhibitor SulA; Region: SulA; cl01880
644801008258	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
644801008259	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
644801008260	active site
644801008261	interdomain interaction site; other site
644801008262	putative metal-binding site [ion binding]; other site
644801008263	nucleotide binding site [chemical binding]; other site
644801008264	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
644801008265	domain I; other site
644801008266	DNA binding groove [nucleotide binding]
644801008267	phosphate binding site [ion binding]; other site
644801008268	domain II; other site
644801008269	domain III; other site
644801008270	nucleotide binding site [chemical binding]; other site
644801008271	catalytic site [active]
644801008272	domain IV; other site
644801008273	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
644801008274	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
644801008275	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
644801008276	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
644801008277	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
644801008278	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
644801008279	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
644801008280	dimer interface [polypeptide binding]; other site
644801008281	active site
644801008282	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
644801008283	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801008284	substrate binding site [chemical binding]; other site
644801008285	oxyanion hole (OAH) forming residues; other site
644801008286	trimer interface [polypeptide binding]; other site
644801008287	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
644801008288	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801008289	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
644801008290	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
644801008291	acetyl-CoA synthetase; Provisional; Region: PRK00174
644801008292	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
644801008293	active site
644801008294	CoA binding site [chemical binding]; other site
644801008295	acyl-activating enzyme (AAE) consensus motif; other site
644801008296	AMP binding site [chemical binding]; other site
644801008297	acetate binding site [chemical binding]; other site
644801008298	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008300	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
644801008301	putative dimerization interface [polypeptide binding]; other site
644801008302	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
644801008303	CoA-transferase family III; Region: CoA_transf_3; pfam02515
644801008304	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
644801008305	active site
644801008306	catalytic residues [active]
644801008307	metal binding site [ion binding]; metal-binding site
644801008308	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
644801008309	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801008310	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801008311	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
644801008312	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
644801008313	CoA-transferase family III; Region: CoA_transf_3; pfam02515
644801008314	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
644801008315	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
644801008316	dimer interface [polypeptide binding]; other site
644801008317	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801008318	metal binding site [ion binding]; metal-binding site
644801008319	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801008320	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801008321	active site
644801008322	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
644801008323	Uncharacterized conserved protein [Function unknown]; Region: COG3777
644801008324	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
644801008325	active site 2 [active]
644801008326	active site 1 [active]
644801008327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008329	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
644801008330	putative dimerization interface [polypeptide binding]; other site
644801008331	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
644801008332	Predicted membrane protein [Function unknown]; Region: COG4325
644801008333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801008334	putative substrate translocation pore; other site
644801008335	hypothetical protein; Provisional; Region: PRK09256
644801008336	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
644801008337	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
644801008338	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801008339	dimerization interface [polypeptide binding]; other site
644801008340	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801008341	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801008342	dimer interface [polypeptide binding]; other site
644801008343	putative CheW interface [polypeptide binding]; other site
644801008344	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
644801008345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
644801008346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801008347	Walker A/P-loop; other site
644801008348	ATP binding site [chemical binding]; other site
644801008349	Q-loop/lid; other site
644801008350	ABC transporter signature motif; other site
644801008351	Walker B; other site
644801008352	D-loop; other site
644801008353	H-loop/switch region; other site
644801008354	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
644801008355	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
644801008356	catalytic residues [active]
644801008357	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
644801008358	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
644801008359	active site residue [active]
644801008360	BolA-like protein; Region: BolA; pfam01722
644801008361	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
644801008362	fumarate hydratase; Provisional; Region: PRK12425
644801008363	Class II fumarases; Region: Fumarase_classII; cd01362
644801008364	active site
644801008365	tetramer interface [polypeptide binding]; other site
644801008366	outer membrane porin, OprD family; Region: OprD; pfam03573
644801008367	benzoate transporter; Region: benE; TIGR00843
644801008368	Benzoate membrane transport protein; Region: BenE; pfam03594
644801008369	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
644801008370	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
644801008371	dimer interface [polypeptide binding]; other site
644801008372	active site
644801008373	Muconolactone delta-isomerase; Region: MIase; cl01992
644801008374	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
644801008375	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
644801008376	octamer interface [polypeptide binding]; other site
644801008377	active site
644801008378	benzoate transport; Region: 2A0115; TIGR00895
644801008379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801008380	putative substrate translocation pore; other site
644801008381	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
644801008382	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
644801008383	putative NAD(P) binding site [chemical binding]; other site
644801008384	active site
644801008385	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
644801008386	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801008387	catalytic loop [active]
644801008388	iron binding site [ion binding]; other site
644801008389	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
644801008390	FAD binding pocket [chemical binding]; other site
644801008391	FAD binding motif [chemical binding]; other site
644801008392	phosphate binding motif [ion binding]; other site
644801008393	beta-alpha-beta structure motif; other site
644801008394	NAD binding pocket [chemical binding]; other site
644801008395	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
644801008396	inter-subunit interface; other site
644801008397	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
644801008398	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
644801008399	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
644801008400	putative alpha subunit interface [polypeptide binding]; other site
644801008401	putative active site [active]
644801008402	putative substrate binding site [chemical binding]; other site
644801008403	Fe binding site [ion binding]; other site
644801008404	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
644801008405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801008406	Helix-turn-helix domain; Region: HTH_18; pfam12833
644801008407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801008408	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
644801008409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801008410	active site
644801008411	phosphorylation site [posttranslational modification]
644801008412	intermolecular recognition site; other site
644801008413	dimerization interface [polypeptide binding]; other site
644801008414	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801008415	Zn2+ binding site [ion binding]; other site
644801008416	Mg2+ binding site [ion binding]; other site
644801008417	Cache domain; Region: Cache_1; pfam02743
644801008418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801008419	putative active site [active]
644801008420	PAS fold; Region: PAS_3; pfam08447
644801008421	heme pocket [chemical binding]; other site
644801008422	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801008423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801008424	dimer interface [polypeptide binding]; other site
644801008425	phosphorylation site [posttranslational modification]
644801008426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801008427	ATP binding site [chemical binding]; other site
644801008428	Mg2+ binding site [ion binding]; other site
644801008429	G-X-G motif; other site
644801008430	Response regulator receiver domain; Region: Response_reg; pfam00072
644801008431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801008432	active site
644801008433	phosphorylation site [posttranslational modification]
644801008434	intermolecular recognition site; other site
644801008435	dimerization interface [polypeptide binding]; other site
644801008436	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
644801008437	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
644801008438	P-loop; other site
644801008439	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
644801008440	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801008441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801008442	active site
644801008443	phosphorylation site [posttranslational modification]
644801008444	intermolecular recognition site; other site
644801008445	dimerization interface [polypeptide binding]; other site
644801008446	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801008447	DNA binding residues [nucleotide binding]
644801008448	dimerization interface [polypeptide binding]; other site
644801008449	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
644801008450	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
644801008451	FMN binding site [chemical binding]; other site
644801008452	active site
644801008453	catalytic residues [active]
644801008454	substrate binding site [chemical binding]; other site
644801008455	transaldolase-like protein; Provisional; Region: PTZ00411
644801008456	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
644801008457	active site
644801008458	dimer interface [polypeptide binding]; other site
644801008459	catalytic residue [active]
644801008460	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
644801008461	anti sigma factor interaction site; other site
644801008462	regulatory phosphorylation site [posttranslational modification]; other site
644801008463	Response regulator receiver domain; Region: Response_reg; pfam00072
644801008464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801008465	active site
644801008466	phosphorylation site [posttranslational modification]
644801008467	intermolecular recognition site; other site
644801008468	dimerization interface [polypeptide binding]; other site
644801008469	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
644801008470	PilZ domain; Region: PilZ; pfam07238
644801008471	VacJ like lipoprotein; Region: VacJ; cl01073
644801008472	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
644801008473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
644801008474	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
644801008475	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
644801008476	inner membrane transport permease; Provisional; Region: PRK15066
644801008477	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
644801008478	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
644801008479	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801008480	Walker A/P-loop; other site
644801008481	ATP binding site [chemical binding]; other site
644801008482	Q-loop/lid; other site
644801008483	ABC transporter signature motif; other site
644801008484	Walker B; other site
644801008485	D-loop; other site
644801008486	H-loop/switch region; other site
644801008487	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
644801008488	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
644801008489	active site
644801008490	Zn binding site [ion binding]; other site
644801008491	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
644801008492	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801008493	inhibitor-cofactor binding pocket; inhibition site
644801008494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801008495	catalytic residue [active]
644801008496	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
644801008497	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801008498	substrate binding site [chemical binding]; other site
644801008499	oxyanion hole (OAH) forming residues; other site
644801008500	trimer interface [polypeptide binding]; other site
644801008501	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
644801008502	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
644801008503	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801008504	Zn2+ binding site [ion binding]; other site
644801008505	Mg2+ binding site [ion binding]; other site
644801008506	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
644801008507	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801008508	active site residue [active]
644801008509	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
644801008510	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801008511	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
644801008512	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
644801008513	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
644801008514	active site
644801008515	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
644801008516	sensor protein RstB; Provisional; Region: PRK10604
644801008517	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801008518	dimerization interface [polypeptide binding]; other site
644801008519	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801008520	dimer interface [polypeptide binding]; other site
644801008521	phosphorylation site [posttranslational modification]
644801008522	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801008523	ATP binding site [chemical binding]; other site
644801008524	Mg2+ binding site [ion binding]; other site
644801008525	G-X-G motif; other site
644801008526	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
644801008527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801008528	active site
644801008529	phosphorylation site [posttranslational modification]
644801008530	intermolecular recognition site; other site
644801008531	dimerization interface [polypeptide binding]; other site
644801008532	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801008533	DNA binding site [nucleotide binding]
644801008534	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
644801008535	ATP cone domain; Region: ATP-cone; pfam03477
644801008536	ATP cone domain; Region: ATP-cone; pfam03477
644801008537	Class I ribonucleotide reductase; Region: RNR_I; cd01679
644801008538	active site
644801008539	dimer interface [polypeptide binding]; other site
644801008540	catalytic residues [active]
644801008541	effector binding site; other site
644801008542	R2 peptide binding site; other site
644801008543	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
644801008544	dimer interface [polypeptide binding]; other site
644801008545	putative radical transfer pathway; other site
644801008546	diiron center [ion binding]; other site
644801008547	tyrosyl radical; other site
644801008548	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
644801008549	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
644801008550	Restriction endonuclease; Region: Mrr_cat; pfam04471
644801008551	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
644801008552	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
644801008553	PLD-like domain; Region: PLDc_2; pfam13091
644801008554	putative homodimer interface [polypeptide binding]; other site
644801008555	putative active site [active]
644801008556	catalytic site [active]
644801008557	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
644801008558	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008559	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
644801008560	dimerization interface [polypeptide binding]; other site
644801008561	substrate binding pocket [chemical binding]; other site
644801008562	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
644801008563	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801008564	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
644801008565	dimer interface [polypeptide binding]; other site
644801008566	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
644801008567	active site
644801008568	heme binding site [chemical binding]; other site
644801008569	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
644801008570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801008571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
644801008572	Coenzyme A binding pocket [chemical binding]; other site
644801008573	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
644801008574	Methyltransferase domain; Region: Methyltransf_12; pfam08242
644801008575	S-adenosylmethionine binding site [chemical binding]; other site
644801008576	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
644801008577	putative hydrophobic ligand binding site [chemical binding]; other site
644801008578	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801008579	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801008580	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
644801008581	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
644801008582	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
644801008583	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801008584	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008586	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
644801008587	putative substrate binding pocket [chemical binding]; other site
644801008588	putative dimerization interface [polypeptide binding]; other site
644801008589	Predicted transcriptional regulators [Transcription]; Region: COG1733
644801008590	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
644801008591	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
644801008592	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
644801008593	NAD(P) binding site [chemical binding]; other site
644801008594	active site
644801008595	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
644801008596	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
644801008597	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
644801008598	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
644801008599	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
644801008600	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
644801008601	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
644801008602	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
644801008603	DNA binding residues [nucleotide binding]
644801008604	dimer interface [polypeptide binding]; other site
644801008605	putative metal binding site [ion binding]; other site
644801008606	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
644801008607	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
644801008608	metal binding site [ion binding]; metal-binding site
644801008609	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
644801008610	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
644801008611	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
644801008612	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
644801008613	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
644801008614	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
644801008615	Putative glucoamylase; Region: Glycoamylase; pfam10091
644801008616	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
644801008617	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
644801008618	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
644801008619	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
644801008620	Peptidase family U32; Region: Peptidase_U32; pfam01136
644801008621	Collagenase; Region: DUF3656; pfam12392
644801008622	Uncharacterized conserved protein [Function unknown]; Region: COG1801
644801008623	Ion transport protein; Region: Ion_trans; pfam00520
644801008624	Ion channel; Region: Ion_trans_2; pfam07885
644801008625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
644801008626	ATP binding site [chemical binding]; other site
644801008627	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
644801008628	putative Mg++ binding site [ion binding]; other site
644801008629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801008630	nucleotide binding region [chemical binding]; other site
644801008631	ATP-binding site [chemical binding]; other site
644801008632	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
644801008633	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
644801008634	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
644801008635	amphipathic channel; other site
644801008636	Asn-Pro-Ala signature motifs; other site
644801008637	glycerol kinase; Provisional; Region: glpK; PRK00047
644801008638	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
644801008639	N- and C-terminal domain interface [polypeptide binding]; other site
644801008640	active site
644801008641	MgATP binding site [chemical binding]; other site
644801008642	catalytic site [active]
644801008643	metal binding site [ion binding]; metal-binding site
644801008644	glycerol binding site [chemical binding]; other site
644801008645	homotetramer interface [polypeptide binding]; other site
644801008646	homodimer interface [polypeptide binding]; other site
644801008647	FBP binding site [chemical binding]; other site
644801008648	protein IIAGlc interface [polypeptide binding]; other site
644801008649	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
644801008650	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801008651	putative DNA binding site [nucleotide binding]; other site
644801008652	putative Zn2+ binding site [ion binding]; other site
644801008653	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
644801008654	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
644801008655	Cell division protein ZapA; Region: ZapA; pfam05164
644801008656	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
644801008657	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
644801008658	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
644801008659	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801008660	dimer interface [polypeptide binding]; other site
644801008661	putative CheW interface [polypeptide binding]; other site
644801008662	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
644801008663	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
644801008664	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
644801008665	30S subunit binding site; other site
644801008666	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
644801008667	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
644801008668	active site
644801008669	dimerization interface [polypeptide binding]; other site
644801008670	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
644801008671	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
644801008672	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
644801008673	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
644801008674	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
644801008675	putative ligand binding site [chemical binding]; other site
644801008676	NAD binding site [chemical binding]; other site
644801008677	dimerization interface [polypeptide binding]; other site
644801008678	catalytic site [active]
644801008679	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
644801008680	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
644801008681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801008682	Zn2+ binding site [ion binding]; other site
644801008683	Mg2+ binding site [ion binding]; other site
644801008684	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
644801008685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
644801008686	MOSC domain; Region: MOSC; pfam03473
644801008687	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
644801008688	hypothetical protein; Provisional; Region: PRK12378
644801008689	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
644801008690	active site
644801008691	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801008692	Ligand Binding Site [chemical binding]; other site
644801008693	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
644801008694	heme-binding site [chemical binding]; other site
644801008695	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
644801008696	active site
644801008697	dimerization interface [polypeptide binding]; other site
644801008698	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
644801008699	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
644801008700	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
644801008701	Na binding site [ion binding]; other site
644801008702	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
644801008703	Coenzyme A binding pocket [chemical binding]; other site
644801008704	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
644801008705	nudix motif; other site
644801008706	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
644801008707	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
644801008708	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801008709	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
644801008710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801008711	DNA binding residues [nucleotide binding]
644801008712	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
644801008713	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
644801008714	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801008715	Domain of unknown function (DUF368); Region: DUF368; pfam04018
644801008716	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
644801008717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801008718	S-adenosylmethionine binding site [chemical binding]; other site
644801008719	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
644801008720	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
644801008721	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
644801008722	Permutation of conserved domain; other site
644801008723	active site
644801008724	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
644801008725	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
644801008726	homotrimer interaction site [polypeptide binding]; other site
644801008727	zinc binding site [ion binding]; other site
644801008728	CDP-binding sites; other site
644801008729	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801008730	dimerization interface [polypeptide binding]; other site
644801008731	putative DNA binding site [nucleotide binding]; other site
644801008732	putative Zn2+ binding site [ion binding]; other site
644801008733	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801008734	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
644801008735	FMN binding site [chemical binding]; other site
644801008736	active site
644801008737	substrate binding site [chemical binding]; other site
644801008738	catalytic residue [active]
644801008739	S-formylglutathione hydrolase; Region: PLN02442
644801008740	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
644801008741	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
644801008742	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
644801008743	substrate binding site [chemical binding]; other site
644801008744	catalytic Zn binding site [ion binding]; other site
644801008745	NAD binding site [chemical binding]; other site
644801008746	structural Zn binding site [ion binding]; other site
644801008747	dimer interface [polypeptide binding]; other site
644801008748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801008749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008750	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
644801008751	putative effector binding pocket; other site
644801008752	putative dimerization interface [polypeptide binding]; other site
644801008753	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
644801008754	30S subunit binding site; other site
644801008755	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
644801008756	substrate binding site; other site
644801008757	dimer interface; other site
644801008758	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
644801008759	Septum formation initiator; Region: DivIC; cl17659
644801008760	enolase; Provisional; Region: eno; PRK00077
644801008761	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
644801008762	dimer interface [polypeptide binding]; other site
644801008763	metal binding site [ion binding]; metal-binding site
644801008764	substrate binding pocket [chemical binding]; other site
644801008765	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
644801008766	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
644801008767	CTP synthetase; Validated; Region: pyrG; PRK05380
644801008768	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
644801008769	Catalytic site [active]
644801008770	active site
644801008771	UTP binding site [chemical binding]; other site
644801008772	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
644801008773	active site
644801008774	putative oxyanion hole; other site
644801008775	catalytic triad [active]
644801008776	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
644801008777	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
644801008778	Ligand Binding Site [chemical binding]; other site
644801008779	TilS substrate binding domain; Region: TilS; pfam09179
644801008780	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
644801008781	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
644801008782	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
644801008783	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
644801008784	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
644801008785	putative active site [active]
644801008786	putative PHP Thumb interface [polypeptide binding]; other site
644801008787	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
644801008788	generic binding surface II; other site
644801008789	generic binding surface I; other site
644801008790	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
644801008791	RNA/DNA hybrid binding site [nucleotide binding]; other site
644801008792	active site
644801008793	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
644801008794	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
644801008795	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
644801008796	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
644801008797	active site
644801008798	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
644801008799	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
644801008800	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
644801008801	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
644801008802	trimer interface [polypeptide binding]; other site
644801008803	active site
644801008804	UDP-GlcNAc binding site [chemical binding]; other site
644801008805	lipid binding site [chemical binding]; lipid-binding site
644801008806	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
644801008807	periplasmic chaperone; Provisional; Region: PRK10780
644801008808	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
644801008809	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
644801008810	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
644801008811	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
644801008812	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
644801008813	Surface antigen; Region: Bac_surface_Ag; pfam01103
644801008814	zinc metallopeptidase RseP; Provisional; Region: PRK10779
644801008815	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
644801008816	active site
644801008817	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
644801008818	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
644801008819	protein binding site [polypeptide binding]; other site
644801008820	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
644801008821	putative substrate binding region [chemical binding]; other site
644801008822	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
644801008823	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
644801008824	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
644801008825	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
644801008826	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
644801008827	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
644801008828	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
644801008829	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
644801008830	catalytic residue [active]
644801008831	putative FPP diphosphate  binding site; other site
644801008832	putative FPP binding hydrophobic cleft; other site
644801008833	dimer interface [polypeptide binding]; other site
644801008834	putative IPP diphosphate binding site; other site
644801008835	ribosome recycling factor; Reviewed; Region: frr; PRK00083
644801008836	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
644801008837	hinge region; other site
644801008838	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
644801008839	putative nucleotide binding site [chemical binding]; other site
644801008840	uridine monophosphate binding site [chemical binding]; other site
644801008841	homohexameric interface [polypeptide binding]; other site
644801008842	elongation factor Ts; Provisional; Region: tsf; PRK09377
644801008843	UBA/TS-N domain; Region: UBA; pfam00627
644801008844	Elongation factor TS; Region: EF_TS; pfam00889
644801008845	Elongation factor TS; Region: EF_TS; pfam00889
644801008846	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
644801008847	rRNA interaction site [nucleotide binding]; other site
644801008848	S8 interaction site; other site
644801008849	putative laminin-1 binding site; other site
644801008850	methionine aminopeptidase; Provisional; Region: PRK08671
644801008851	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
644801008852	active site
644801008853	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
644801008854	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
644801008855	metal binding triad; other site
644801008856	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
644801008857	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801008858	Zn2+ binding site [ion binding]; other site
644801008859	Mg2+ binding site [ion binding]; other site
644801008860	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
644801008861	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
644801008862	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
644801008863	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
644801008864	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
644801008865	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
644801008866	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801008867	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
644801008868	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
644801008869	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801008870	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
644801008871	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
644801008872	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
644801008873	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
644801008874	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
644801008875	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
644801008876	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801008877	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801008878	ligand binding site [chemical binding]; other site
644801008879	Beta-lactamase; Region: Beta-lactamase; pfam00144
644801008880	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
644801008881	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
644801008882	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
644801008883	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
644801008884	Predicted integral membrane protein [Function unknown]; Region: COG5615
644801008885	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801008886	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801008887	ligand binding site [chemical binding]; other site
644801008888	hypothetical protein; Provisional; Region: PRK00183
644801008889	SEC-C motif; Region: SEC-C; pfam02810
644801008890	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
644801008891	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
644801008892	FAD binding pocket [chemical binding]; other site
644801008893	FAD binding motif [chemical binding]; other site
644801008894	phosphate binding motif [ion binding]; other site
644801008895	beta-alpha-beta structure motif; other site
644801008896	NAD binding pocket [chemical binding]; other site
644801008897	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
644801008898	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801008899	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
644801008900	putative dimerization interface [polypeptide binding]; other site
644801008901	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801008902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801008903	active site
644801008904	phosphorylation site [posttranslational modification]
644801008905	intermolecular recognition site; other site
644801008906	dimerization interface [polypeptide binding]; other site
644801008907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801008908	DNA binding residues [nucleotide binding]
644801008909	dimerization interface [polypeptide binding]; other site
644801008910	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
644801008911	EamA-like transporter family; Region: EamA; pfam00892
644801008912	Uncharacterized conserved protein [Function unknown]; Region: COG3148
644801008913	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
644801008914	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
644801008915	XFP N-terminal domain; Region: XFP_N; pfam09364
644801008916	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
644801008917	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
644801008918	Beta-Casp domain; Region: Beta-Casp; smart01027
644801008919	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
644801008920	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
644801008921	recombination regulator RecX; Reviewed; Region: recX; PRK00117
644801008922	recombinase A; Provisional; Region: recA; PRK09354
644801008923	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
644801008924	hexamer interface [polypeptide binding]; other site
644801008925	Walker A motif; other site
644801008926	ATP binding site [chemical binding]; other site
644801008927	Walker B motif; other site
644801008928	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
644801008929	Acyltransferase family; Region: Acyl_transf_3; pfam01757
644801008930	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
644801008931	MutS domain I; Region: MutS_I; pfam01624
644801008932	MutS domain II; Region: MutS_II; pfam05188
644801008933	MutS domain III; Region: MutS_III; pfam05192
644801008934	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
644801008935	Walker A/P-loop; other site
644801008936	ATP binding site [chemical binding]; other site
644801008937	Q-loop/lid; other site
644801008938	ABC transporter signature motif; other site
644801008939	Walker B; other site
644801008940	D-loop; other site
644801008941	H-loop/switch region; other site
644801008942	Ferredoxin [Energy production and conversion]; Region: COG1146
644801008943	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
644801008944	CsbD-like; Region: CsbD; pfam05532
644801008945	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
644801008946	Predicted deacetylase [General function prediction only]; Region: COG3233
644801008947	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
644801008948	putative active site [active]
644801008949	putative Zn binding site [ion binding]; other site
644801008950	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
644801008951	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
644801008952	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
644801008953	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
644801008954	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
644801008955	Acid Phosphatase; Region: Acid_PPase; cl17256
644801008956	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
644801008957	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
644801008958	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
644801008959	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801008960	putative active site [active]
644801008961	heme pocket [chemical binding]; other site
644801008962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801008963	Walker A motif; other site
644801008964	ATP binding site [chemical binding]; other site
644801008965	Walker B motif; other site
644801008966	arginine finger; other site
644801008967	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801008968	SnoaL-like domain; Region: SnoaL_2; pfam12680
644801008969	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
644801008970	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
644801008971	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801008972	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801008973	metal binding site [ion binding]; metal-binding site
644801008974	active site
644801008975	I-site; other site
644801008976	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
644801008977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801008978	N-terminal plug; other site
644801008979	ligand-binding site [chemical binding]; other site
644801008980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801008981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801008982	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
644801008983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801008984	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
644801008985	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801008986	sequence-specific DNA binding site [nucleotide binding]; other site
644801008987	salt bridge; other site
644801008988	Protein of unknown function DUF262; Region: DUF262; pfam03235
644801008989	Uncharacterized conserved protein [Function unknown]; Region: COG1479
644801008990	Uncharacterized conserved protein [Function unknown]; Region: COG3472
644801008991	Helix-turn-helix domain; Region: HTH_17; cl17695
644801008992	integrase; Provisional; Region: int; PHA02601
644801008993	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801008994	active site
644801008995	DNA binding site [nucleotide binding]
644801008996	Int/Topo IB signature motif; other site
644801008997	Fic/DOC family; Region: Fic; cl00960
644801008998	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
644801008999	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
644801009000	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
644801009001	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
644801009002	Protein of unknown function, DUF488; Region: DUF488; pfam04343
644801009003	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
644801009004	S1 domain; Region: S1_2; pfam13509
644801009005	S1 domain; Region: S1_2; pfam13509
644801009006	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
644801009007	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
644801009008	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
644801009009	Trp docking motif [polypeptide binding]; other site
644801009010	putative active site [active]
644801009011	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
644801009012	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
644801009013	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
644801009014	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801009015	RNA binding surface [nucleotide binding]; other site
644801009016	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
644801009017	active site
644801009018	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
644801009019	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
644801009020	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
644801009021	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801009022	ATP binding site [chemical binding]; other site
644801009023	putative Mg++ binding site [ion binding]; other site
644801009024	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801009025	nucleotide binding region [chemical binding]; other site
644801009026	ATP-binding site [chemical binding]; other site
644801009027	DEAD/H associated; Region: DEAD_assoc; pfam08494
644801009028	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
644801009029	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
644801009030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801009031	NAD(P) binding site [chemical binding]; other site
644801009032	active site
644801009033	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
644801009034	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
644801009035	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
644801009036	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
644801009037	Methyltransferase domain; Region: Methyltransf_25; pfam13649
644801009038	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
644801009039	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
644801009040	active site
644801009041	catalytic residues [active]
644801009042	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
644801009043	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
644801009044	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
644801009045	active site
644801009046	dimer interface [polypeptide binding]; other site
644801009047	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
644801009048	Ligand Binding Site [chemical binding]; other site
644801009049	Molecular Tunnel; other site
644801009050	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
644801009051	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801009052	Coenzyme A binding pocket [chemical binding]; other site
644801009053	ATP-grasp domain; Region: ATP-grasp_4; cl17255
644801009054	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
644801009055	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
644801009056	putative oligomer interface [polypeptide binding]; other site
644801009057	putative active site [active]
644801009058	metal binding site [ion binding]; metal-binding site
644801009059	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
644801009060	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
644801009061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801009062	dimer interface [polypeptide binding]; other site
644801009063	phosphorylation site [posttranslational modification]
644801009064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801009065	ATP binding site [chemical binding]; other site
644801009066	Mg2+ binding site [ion binding]; other site
644801009067	G-X-G motif; other site
644801009068	Response regulator receiver domain; Region: Response_reg; pfam00072
644801009069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801009070	active site
644801009071	phosphorylation site [posttranslational modification]
644801009072	intermolecular recognition site; other site
644801009073	dimerization interface [polypeptide binding]; other site
644801009074	hypothetical protein; Provisional; Region: PRK00304
644801009075	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
644801009076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801009077	short chain dehydrogenase; Provisional; Region: PRK05650
644801009078	classical (c) SDRs; Region: SDR_c; cd05233
644801009079	NAD(P) binding site [chemical binding]; other site
644801009080	active site
644801009081	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
644801009082	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
644801009083	Na binding site [ion binding]; other site
644801009084	Predicted membrane protein [Function unknown]; Region: COG3162
644801009085	Predicted membrane protein [Function unknown]; Region: COG3205
644801009086	VacJ like lipoprotein; Region: VacJ; cl01073
644801009087	Pirin-related protein [General function prediction only]; Region: COG1741
644801009088	Pirin; Region: Pirin; pfam02678
644801009089	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
644801009090	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
644801009091	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
644801009092	putative acyl-acceptor binding pocket; other site
644801009093	septum formation inhibitor; Reviewed; Region: minC; PRK00339
644801009094	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
644801009095	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
644801009096	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
644801009097	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
644801009098	Switch I; other site
644801009099	Switch II; other site
644801009100	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
644801009101	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
644801009102	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
644801009103	active site
644801009104	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
644801009105	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
644801009106	active site
644801009107	metal binding site [ion binding]; metal-binding site
644801009108	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
644801009109	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
644801009110	NAD(P) binding site [chemical binding]; other site
644801009111	carboxy-terminal protease; Provisional; Region: PRK11186
644801009112	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
644801009113	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
644801009114	protein binding site [polypeptide binding]; other site
644801009115	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
644801009116	Catalytic dyad [active]
644801009117	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
644801009118	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
644801009119	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
644801009120	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801009121	salt bridge; other site
644801009122	non-specific DNA binding site [nucleotide binding]; other site
644801009123	sequence-specific DNA binding site [nucleotide binding]; other site
644801009124	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
644801009125	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
644801009126	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
644801009127	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
644801009128	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
644801009129	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
644801009130	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801009131	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
644801009132	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
644801009133	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
644801009134	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
644801009135	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
644801009136	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
644801009137	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
644801009138	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
644801009139	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
644801009140	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801009141	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
644801009142	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
644801009143	flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637
644801009144	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
644801009145	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
644801009146	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801009147	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
644801009148	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
644801009149	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
644801009150	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
644801009151	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
644801009152	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801009153	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
644801009154	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
644801009155	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
644801009156	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
644801009157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801009158	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
644801009159	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801009160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801009161	active site
644801009162	phosphorylation site [posttranslational modification]
644801009163	intermolecular recognition site; other site
644801009164	dimerization interface [polypeptide binding]; other site
644801009165	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
644801009166	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
644801009167	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
644801009168	FlgN protein; Region: FlgN; pfam05130
644801009169	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
644801009170	PilZ domain; Region: PilZ; pfam07238
644801009171	Arc-like DNA binding domain; Region: Arc; pfam03869
644801009172	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
644801009173	oxaloacetate decarboxylase; Provisional; Region: PRK14040
644801009174	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
644801009175	active site
644801009176	catalytic residues [active]
644801009177	metal binding site [ion binding]; metal-binding site
644801009178	homodimer binding site [polypeptide binding]; other site
644801009179	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
644801009180	carboxyltransferase (CT) interaction site; other site
644801009181	biotinylation site [posttranslational modification]; other site
644801009182	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
644801009183	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
644801009184	MgtE intracellular N domain; Region: MgtE_N; smart00924
644801009185	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
644801009186	Divalent cation transporter; Region: MgtE; cl00786
644801009187	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801009188	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
644801009189	carbon storage regulator; Provisional; Region: PRK01712
644801009190	aspartate kinase; Reviewed; Region: PRK06635
644801009191	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
644801009192	putative nucleotide binding site [chemical binding]; other site
644801009193	putative catalytic residues [active]
644801009194	putative Mg ion binding site [ion binding]; other site
644801009195	putative aspartate binding site [chemical binding]; other site
644801009196	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
644801009197	putative allosteric regulatory site; other site
644801009198	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
644801009199	putative allosteric regulatory residue; other site
644801009200	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
644801009201	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
644801009202	motif 1; other site
644801009203	active site
644801009204	motif 2; other site
644801009205	motif 3; other site
644801009206	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
644801009207	DHHA1 domain; Region: DHHA1; pfam02272
644801009208	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
644801009209	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
644801009210	tetramer interface [polypeptide binding]; other site
644801009211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801009212	catalytic residue [active]
644801009213	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
644801009214	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
644801009215	hypothetical protein; Provisional; Region: PRK05170
644801009216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
644801009217	ribonuclease D; Region: rnd; TIGR01388
644801009218	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
644801009219	catalytic site [active]
644801009220	putative active site [active]
644801009221	putative substrate binding site [chemical binding]; other site
644801009222	HRDC domain; Region: HRDC; pfam00570
644801009223	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
644801009224	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
644801009225	active site residue [active]
644801009226	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
644801009227	active site residue [active]
644801009228	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
644801009229	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
644801009230	catalytic residues [active]
644801009231	dimer interface [polypeptide binding]; other site
644801009232	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
644801009233	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
644801009234	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
644801009235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801009236	dimer interface [polypeptide binding]; other site
644801009237	conserved gate region; other site
644801009238	putative PBP binding loops; other site
644801009239	ABC-ATPase subunit interface; other site
644801009240	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
644801009241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801009242	Walker A/P-loop; other site
644801009243	ATP binding site [chemical binding]; other site
644801009244	Q-loop/lid; other site
644801009245	ABC transporter signature motif; other site
644801009246	Walker B; other site
644801009247	D-loop; other site
644801009248	H-loop/switch region; other site
644801009249	TOBE domain; Region: TOBE; pfam03459
644801009250	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
644801009251	homotrimer interaction site [polypeptide binding]; other site
644801009252	putative active site [active]
644801009253	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801009254	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801009255	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
644801009256	putative effector binding pocket; other site
644801009257	putative dimerization interface [polypeptide binding]; other site
644801009258	cobalamin synthase; Reviewed; Region: cobS; PRK00235
644801009259	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
644801009260	catalytic core [active]
644801009261	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
644801009262	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
644801009263	putative dimer interface [polypeptide binding]; other site
644801009264	active site pocket [active]
644801009265	putative cataytic base [active]
644801009266	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
644801009267	homotrimer interface [polypeptide binding]; other site
644801009268	Walker A motif; other site
644801009269	GTP binding site [chemical binding]; other site
644801009270	Walker B motif; other site
644801009271	cobyric acid synthase; Provisional; Region: PRK00784
644801009272	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
644801009273	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
644801009274	catalytic triad [active]
644801009275	threonine-phosphate decarboxylase; Reviewed; Region: PRK05664
644801009276	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
644801009277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801009278	catalytic residue [active]
644801009279	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
644801009280	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
644801009281	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
644801009282	cobalamin binding residues [chemical binding]; other site
644801009283	putative BtuC binding residues; other site
644801009284	dimer interface [polypeptide binding]; other site
644801009285	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
644801009286	putative FMN binding site [chemical binding]; other site
644801009287	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
644801009288	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
644801009289	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
644801009290	catalytic triad [active]
644801009291	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
644801009292	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
644801009293	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
644801009294	Walker A motif; other site
644801009295	homodimer interface [polypeptide binding]; other site
644801009296	ATP binding site [chemical binding]; other site
644801009297	hydroxycobalamin binding site [chemical binding]; other site
644801009298	Walker B motif; other site
644801009299	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
644801009300	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801009301	N-terminal plug; other site
644801009302	ligand-binding site [chemical binding]; other site
644801009303	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
644801009304	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
644801009305	putative active site [active]
644801009306	putative metal binding site [ion binding]; other site
644801009307	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
644801009308	active site
644801009309	metal binding site [ion binding]; metal-binding site
644801009310	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
644801009311	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
644801009312	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
644801009313	NlpC/P60 family; Region: NLPC_P60; pfam00877
644801009314	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
644801009315	NlpC/P60 family; Region: NLPC_P60; pfam00877
644801009316	NAD-dependent deacetylase; Provisional; Region: PRK00481
644801009317	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
644801009318	NAD+ binding site [chemical binding]; other site
644801009319	substrate binding site [chemical binding]; other site
644801009320	Zn binding site [ion binding]; other site
644801009321	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
644801009322	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
644801009323	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
644801009324	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
644801009325	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
644801009326	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
644801009327	AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061
644801009328	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
644801009329	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
644801009330	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
644801009331	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
644801009332	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
644801009333	Ligand Binding Site [chemical binding]; other site
644801009334	DNA-J related protein; Region: DNAJ_related; pfam12339
644801009335	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
644801009336	HSP70 interaction site [polypeptide binding]; other site
644801009337	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
644801009338	Yip1 domain; Region: Yip1; pfam04893
644801009339	hypothetical protein; Provisional; Region: PRK04860
644801009340	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
644801009341	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
644801009342	NapD protein; Region: NapD; pfam03927
644801009343	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
644801009344	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
644801009345	[4Fe-4S] binding site [ion binding]; other site
644801009346	molybdopterin cofactor binding site; other site
644801009347	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
644801009348	molybdopterin cofactor binding site; other site
644801009349	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
644801009350	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
644801009351	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
644801009352	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
644801009353	trimer interface [polypeptide binding]; other site
644801009354	active site
644801009355	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801009356	DNA-binding site [nucleotide binding]; DNA binding site
644801009357	RNA-binding motif; other site
644801009358	antiporter inner membrane protein; Provisional; Region: PRK11670
644801009359	Domain of unknown function DUF59; Region: DUF59; pfam01883
644801009360	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
644801009361	Walker A motif; other site
644801009362	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
644801009363	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
644801009364	active site
644801009365	HIGH motif; other site
644801009366	KMSKS motif; other site
644801009367	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
644801009368	tRNA binding surface [nucleotide binding]; other site
644801009369	anticodon binding site; other site
644801009370	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
644801009371	dimer interface [polypeptide binding]; other site
644801009372	putative tRNA-binding site [nucleotide binding]; other site
644801009373	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
644801009374	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
644801009375	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801009376	RNA binding surface [nucleotide binding]; other site
644801009377	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
644801009378	active site
644801009379	uracil binding [chemical binding]; other site
644801009380	Flagellin N-methylase; Region: FliB; cl00497
644801009381	integrase; Provisional; Region: int; PHA02601
644801009382	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801009383	active site
644801009384	DNA binding site [nucleotide binding]
644801009385	Int/Topo IB signature motif; other site
644801009386	Zonular occludens toxin (Zot); Region: Zot; cl17485
644801009387	Protein of unknown function (DUF2523); Region: DUF2523; pfam10734
644801009388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
644801009389	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
644801009390	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
644801009391	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
644801009392	dimer interface [polypeptide binding]; other site
644801009393	active site
644801009394	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
644801009395	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
644801009396	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
644801009397	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
644801009398	Bacterial transcriptional regulator; Region: IclR; pfam01614
644801009399	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
644801009400	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
644801009401	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
644801009402	Na binding site [ion binding]; other site
644801009403	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
644801009404	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801009405	N-terminal plug; other site
644801009406	ligand-binding site [chemical binding]; other site
644801009407	Protein of unknown function (DUF3203); Region: DUF3203; pfam11462
644801009408	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
644801009409	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
644801009410	Na binding site [ion binding]; other site
644801009411	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
644801009412	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
644801009413	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
644801009414	Glutamate binding site [chemical binding]; other site
644801009415	NAD binding site [chemical binding]; other site
644801009416	catalytic residues [active]
644801009417	Cupin domain; Region: Cupin_2; cl17218
644801009418	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801009419	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801009420	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801009421	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
644801009422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801009423	Walker A motif; other site
644801009424	ATP binding site [chemical binding]; other site
644801009425	Walker B motif; other site
644801009426	arginine finger; other site
644801009427	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
644801009428	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
644801009429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801009430	S-adenosylmethionine binding site [chemical binding]; other site
644801009431	Methyltransferase domain; Region: Methyltransf_31; pfam13847
644801009432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801009433	S-adenosylmethionine binding site [chemical binding]; other site
644801009434	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801009435	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
644801009436	dimerization interface [polypeptide binding]; other site
644801009437	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
644801009438	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
644801009439	active site
644801009440	hydrophilic channel; other site
644801009441	dimerization interface [polypeptide binding]; other site
644801009442	catalytic residues [active]
644801009443	active site lid [active]
644801009444	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
644801009445	Recombination protein O N terminal; Region: RecO_N; pfam11967
644801009446	Recombination protein O C terminal; Region: RecO_C; pfam02565
644801009447	GTPase Era; Reviewed; Region: era; PRK00089
644801009448	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
644801009449	G1 box; other site
644801009450	GTP/Mg2+ binding site [chemical binding]; other site
644801009451	Switch I region; other site
644801009452	G2 box; other site
644801009453	Switch II region; other site
644801009454	G3 box; other site
644801009455	G4 box; other site
644801009456	G5 box; other site
644801009457	KH domain; Region: KH_2; pfam07650
644801009458	ribonuclease III; Reviewed; Region: rnc; PRK00102
644801009459	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
644801009460	dimerization interface [polypeptide binding]; other site
644801009461	active site
644801009462	metal binding site [ion binding]; metal-binding site
644801009463	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
644801009464	signal peptidase I; Provisional; Region: PRK10861
644801009465	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
644801009466	Catalytic site [active]
644801009467	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
644801009468	GTP-binding protein LepA; Provisional; Region: PRK05433
644801009469	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
644801009470	G1 box; other site
644801009471	putative GEF interaction site [polypeptide binding]; other site
644801009472	GTP/Mg2+ binding site [chemical binding]; other site
644801009473	Switch I region; other site
644801009474	G2 box; other site
644801009475	G3 box; other site
644801009476	Switch II region; other site
644801009477	G4 box; other site
644801009478	G5 box; other site
644801009479	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
644801009480	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
644801009481	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
644801009482	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
644801009483	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
644801009484	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
644801009485	protein binding site [polypeptide binding]; other site
644801009486	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
644801009487	protein binding site [polypeptide binding]; other site
644801009488	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
644801009489	anti-sigma E factor; Provisional; Region: rseB; PRK09455
644801009490	MucB/RseB family; Region: MucB_RseB; pfam03888
644801009491	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
644801009492	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
644801009493	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
644801009494	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
644801009495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801009496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801009497	DNA binding residues [nucleotide binding]
644801009498	L-aspartate oxidase; Provisional; Region: PRK09077
644801009499	L-aspartate oxidase; Provisional; Region: PRK06175
644801009500	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
644801009501	Uncharacterized conserved protein [Function unknown]; Region: COG2938
644801009502	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
644801009503	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
644801009504	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
644801009505	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
644801009506	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
644801009507	ligand binding site [chemical binding]; other site
644801009508	active site
644801009509	UGI interface [polypeptide binding]; other site
644801009510	catalytic site [active]
644801009511	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
644801009512	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
644801009513	putative ligand binding site [chemical binding]; other site
644801009514	enoyl-CoA hydratase; Provisional; Region: PRK09076
644801009515	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801009516	substrate binding site [chemical binding]; other site
644801009517	oxyanion hole (OAH) forming residues; other site
644801009518	trimer interface [polypeptide binding]; other site
644801009519	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
644801009520	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801009521	substrate binding site [chemical binding]; other site
644801009522	oxyanion hole (OAH) forming residues; other site
644801009523	trimer interface [polypeptide binding]; other site
644801009524	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
644801009525	electron transport complex protein RsxA; Provisional; Region: PRK05151
644801009526	ferredoxin; Provisional; Region: PRK08764
644801009527	Putative Fe-S cluster; Region: FeS; pfam04060
644801009528	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
644801009529	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
644801009530	SLBB domain; Region: SLBB; pfam10531
644801009531	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
644801009532	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
644801009533	FMN-binding domain; Region: FMN_bind; cl01081
644801009534	electron transport complex RsxE subunit; Provisional; Region: PRK12405
644801009535	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
644801009536	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
644801009537	minor groove reading motif; other site
644801009538	helix-hairpin-helix signature motif; other site
644801009539	substrate binding pocket [chemical binding]; other site
644801009540	active site
644801009541	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
644801009542	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801009543	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
644801009544	dimer interface [polypeptide binding]; other site
644801009545	active site
644801009546	metal binding site [ion binding]; metal-binding site
644801009547	glutathione binding site [chemical binding]; other site
644801009548	argininosuccinate synthase; Provisional; Region: PRK13820
644801009549	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
644801009550	ANP binding site [chemical binding]; other site
644801009551	Substrate Binding Site II [chemical binding]; other site
644801009552	Substrate Binding Site I [chemical binding]; other site
644801009553	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801009554	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801009555	ligand binding site [chemical binding]; other site
644801009556	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
644801009557	active site
644801009558	substrate binding pocket [chemical binding]; other site
644801009559	dimer interface [polypeptide binding]; other site
644801009560	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
644801009561	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
644801009562	dimer interface [polypeptide binding]; other site
644801009563	catalytic site [active]
644801009564	putative active site [active]
644801009565	putative substrate binding site [chemical binding]; other site
644801009566	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
644801009567	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
644801009568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801009569	catalytic residue [active]
644801009570	homoserine dehydrogenase; Provisional; Region: PRK06349
644801009571	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
644801009572	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
644801009573	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
644801009574	Uncharacterized conserved protein [Function unknown]; Region: COG3791
644801009575	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
644801009576	dimerization domain [polypeptide binding]; other site
644801009577	dimer interface [polypeptide binding]; other site
644801009578	catalytic residues [active]
644801009579	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
644801009580	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
644801009581	active site
644801009582	Int/Topo IB signature motif; other site
644801009583	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
644801009584	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
644801009585	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
644801009586	RimM N-terminal domain; Region: RimM; pfam01782
644801009587	PRC-barrel domain; Region: PRC; pfam05239
644801009588	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
644801009589	signal recognition particle protein; Provisional; Region: PRK10867
644801009590	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
644801009591	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
644801009592	P loop; other site
644801009593	GTP binding site [chemical binding]; other site
644801009594	Signal peptide binding domain; Region: SRP_SPB; pfam02978
644801009595	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
644801009596	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
644801009597	Domain of unknown function DUF21; Region: DUF21; pfam01595
644801009598	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
644801009599	Transporter associated domain; Region: CorC_HlyC; smart01091
644801009600	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
644801009601	ATP-grasp domain; Region: ATP-grasp; pfam02222
644801009602	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
644801009603	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
644801009604	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
644801009605	trimer interface [polypeptide binding]; other site
644801009606	putative metal binding site [ion binding]; other site
644801009607	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
644801009608	putative active site [active]
644801009609	putative CoA binding site [chemical binding]; other site
644801009610	nudix motif; other site
644801009611	metal binding site [ion binding]; metal-binding site
644801009612	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
644801009613	nudix motif; other site
644801009614	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
644801009615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
644801009616	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801009617	active site
644801009618	Int/Topo IB signature motif; other site
644801009619	catalytic residues [active]
644801009620	DNA binding site [nucleotide binding]
644801009621	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
644801009622	Phage associated DNA primase [General function prediction only]; Region: COG3378
644801009623	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
644801009624	multiple promoter invertase; Provisional; Region: mpi; PRK13413
644801009625	catalytic residues [active]
644801009626	catalytic nucleophile [active]
644801009627	Presynaptic Site I dimer interface [polypeptide binding]; other site
644801009628	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
644801009629	Synaptic Flat tetramer interface [polypeptide binding]; other site
644801009630	Synaptic Site I dimer interface [polypeptide binding]; other site
644801009631	DNA binding site [nucleotide binding]
644801009632	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
644801009633	DNA-binding interface [nucleotide binding]; DNA binding site
644801009634	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
644801009635	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
644801009636	dimerization interface [polypeptide binding]; other site
644801009637	ATP binding site [chemical binding]; other site
644801009638	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
644801009639	dimerization interface [polypeptide binding]; other site
644801009640	ATP binding site [chemical binding]; other site
644801009641	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
644801009642	putative active site [active]
644801009643	catalytic triad [active]
644801009644	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
644801009645	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
644801009646	Walker A/P-loop; other site
644801009647	ATP binding site [chemical binding]; other site
644801009648	Q-loop/lid; other site
644801009649	ABC transporter signature motif; other site
644801009650	Walker B; other site
644801009651	D-loop; other site
644801009652	H-loop/switch region; other site
644801009653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801009654	dimer interface [polypeptide binding]; other site
644801009655	conserved gate region; other site
644801009656	putative PBP binding loops; other site
644801009657	ABC-ATPase subunit interface; other site
644801009658	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
644801009659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801009660	conserved gate region; other site
644801009661	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801009662	putative PBP binding loops; other site
644801009663	dimer interface [polypeptide binding]; other site
644801009664	ABC-ATPase subunit interface; other site
644801009665	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
644801009666	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801009667	substrate binding pocket [chemical binding]; other site
644801009668	membrane-bound complex binding site; other site
644801009669	hinge residues; other site
644801009670	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
644801009671	Serine hydrolase (FSH1); Region: FSH1; pfam03959
644801009672	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801009673	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801009674	ligand binding site [chemical binding]; other site
644801009675	flexible hinge region; other site
644801009676	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801009677	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801009678	metal binding site [ion binding]; metal-binding site
644801009679	active site
644801009680	I-site; other site
644801009681	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297
644801009682	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
644801009683	ATP binding site [chemical binding]; other site
644801009684	Mg++ binding site [ion binding]; other site
644801009685	motif III; other site
644801009686	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801009687	nucleotide binding region [chemical binding]; other site
644801009688	ATP-binding site [chemical binding]; other site
644801009689	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
644801009690	MoaE homodimer interface [polypeptide binding]; other site
644801009691	MoaD interaction [polypeptide binding]; other site
644801009692	active site residues [active]
644801009693	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
644801009694	MoaE interaction surface [polypeptide binding]; other site
644801009695	MoeB interaction surface [polypeptide binding]; other site
644801009696	thiocarboxylated glycine; other site
644801009697	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
644801009698	trimer interface [polypeptide binding]; other site
644801009699	dimer interface [polypeptide binding]; other site
644801009700	putative active site [active]
644801009701	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
644801009702	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
644801009703	putative active site [active]
644801009704	PhoH-like protein; Region: PhoH; pfam02562
644801009705	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
644801009706	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
644801009707	hypothetical protein; Validated; Region: PRK02101
644801009708	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
644801009709	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
644801009710	Substrate binding site; other site
644801009711	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
644801009712	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
644801009713	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
644801009714	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
644801009715	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
644801009716	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
644801009717	putative active site [active]
644801009718	putative substrate binding site [chemical binding]; other site
644801009719	putative cosubstrate binding site; other site
644801009720	catalytic site [active]
644801009721	exonuclease I; Provisional; Region: sbcB; PRK11779
644801009722	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
644801009723	active site
644801009724	catalytic site [active]
644801009725	substrate binding site [chemical binding]; other site
644801009726	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
644801009727	RDD family; Region: RDD; pfam06271
644801009728	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
644801009729	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
644801009730	MoxR-like ATPases [General function prediction only]; Region: COG0714
644801009731	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801009732	Walker A motif; other site
644801009733	ATP binding site [chemical binding]; other site
644801009734	Walker B motif; other site
644801009735	arginine finger; other site
644801009736	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
644801009737	Protein of unknown function DUF58; Region: DUF58; pfam01882
644801009738	PilZ domain; Region: PilZ; pfam07238
644801009739	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801009740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
644801009741	pyruvate kinase; Provisional; Region: PRK05826
644801009742	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
644801009743	domain interfaces; other site
644801009744	active site
644801009745	hypothetical protein; Provisional; Region: PRK05713
644801009746	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801009747	catalytic loop [active]
644801009748	iron binding site [ion binding]; other site
644801009749	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
644801009750	FAD binding pocket [chemical binding]; other site
644801009751	conserved FAD binding motif [chemical binding]; other site
644801009752	phosphate binding motif [ion binding]; other site
644801009753	beta-alpha-beta structure motif; other site
644801009754	NAD binding pocket [chemical binding]; other site
644801009755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801009756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801009757	metal binding site [ion binding]; metal-binding site
644801009758	active site
644801009759	I-site; other site
644801009760	putative fumarate hydratase; Provisional; Region: PRK15392
644801009761	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
644801009762	Fumarase C-terminus; Region: Fumerase_C; pfam05683
644801009763	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
644801009764	intracellular protease, PfpI family; Region: PfpI; TIGR01382
644801009765	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
644801009766	conserved cys residue [active]
644801009767	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
644801009768	putative active site [active]
644801009769	catalytic site [active]
644801009770	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
644801009771	PLD-like domain; Region: PLDc_2; pfam13091
644801009772	putative active site [active]
644801009773	catalytic site [active]
644801009774	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801009775	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
644801009776	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
644801009777	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
644801009778	putative acyl-acceptor binding pocket; other site
644801009779	Protein of unknown function, DUF479; Region: DUF479; cl01203
644801009780	aldolase II superfamily protein; Provisional; Region: PRK07044
644801009781	intersubunit interface [polypeptide binding]; other site
644801009782	active site
644801009783	Zn2+ binding site [ion binding]; other site
644801009784	flavodoxin; Provisional; Region: PRK05723
644801009785	PilZ domain; Region: PilZ; pfam07238
644801009786	dihydromonapterin reductase; Provisional; Region: PRK06483
644801009787	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
644801009788	NADP binding site [chemical binding]; other site
644801009789	substrate binding pocket [chemical binding]; other site
644801009790	active site
644801009791	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
644801009792	homooctamer interface [polypeptide binding]; other site
644801009793	active site
644801009794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
644801009795	HopJ type III effector protein; Region: HopJ; pfam08888
644801009796	putative sulfate transport protein CysZ; Validated; Region: PRK04949
644801009797	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
644801009798	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
644801009799	putative active site [active]
644801009800	putative FMN binding site [chemical binding]; other site
644801009801	putative substrate binding site [chemical binding]; other site
644801009802	putative catalytic residue [active]
644801009803	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801009804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801009805	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
644801009806	catalytic residues [active]
644801009807	dimer interface [polypeptide binding]; other site
644801009808	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
644801009809	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
644801009810	propionate/acetate kinase; Provisional; Region: PRK12379
644801009811	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
644801009812	nucleotide binding site [chemical binding]; other site
644801009813	butyrate kinase; Provisional; Region: PRK03011
644801009814	phosphate acetyltransferase; Reviewed; Region: PRK05632
644801009815	DRTGG domain; Region: DRTGG; pfam07085
644801009816	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
644801009817	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
644801009818	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
644801009819	putative acyl-acceptor binding pocket; other site
644801009820	Response regulator receiver domain; Region: Response_reg; pfam00072
644801009821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801009822	active site
644801009823	phosphorylation site [posttranslational modification]
644801009824	intermolecular recognition site; other site
644801009825	dimerization interface [polypeptide binding]; other site
644801009826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801009827	putative active site [active]
644801009828	heme pocket [chemical binding]; other site
644801009829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801009830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801009831	metal binding site [ion binding]; metal-binding site
644801009832	active site
644801009833	I-site; other site
644801009834	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801009835	CHASE domain; Region: CHASE; pfam03924
644801009836	PAS domain S-box; Region: sensory_box; TIGR00229
644801009837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801009838	putative active site [active]
644801009839	heme pocket [chemical binding]; other site
644801009840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
644801009841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801009842	putative active site [active]
644801009843	heme pocket [chemical binding]; other site
644801009844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801009845	dimer interface [polypeptide binding]; other site
644801009846	phosphorylation site [posttranslational modification]
644801009847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801009848	ATP binding site [chemical binding]; other site
644801009849	Mg2+ binding site [ion binding]; other site
644801009850	G-X-G motif; other site
644801009851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801009852	Response regulator receiver domain; Region: Response_reg; pfam00072
644801009853	active site
644801009854	phosphorylation site [posttranslational modification]
644801009855	intermolecular recognition site; other site
644801009856	dimerization interface [polypeptide binding]; other site
644801009857	cheY-homologous receiver domain; Region: REC; smart00448
644801009858	Response regulator receiver domain; Region: Response_reg; pfam00072
644801009859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801009860	active site
644801009861	phosphorylation site [posttranslational modification]
644801009862	intermolecular recognition site; other site
644801009863	dimerization interface [polypeptide binding]; other site
644801009864	putative outer membrane lipoprotein; Provisional; Region: PRK10510
644801009865	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801009866	ligand binding site [chemical binding]; other site
644801009867	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
644801009868	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
644801009869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
644801009870	acyl-activating enzyme (AAE) consensus motif; other site
644801009871	AMP binding site [chemical binding]; other site
644801009872	active site
644801009873	CoA binding site [chemical binding]; other site
644801009874	LysE type translocator; Region: LysE; cl00565
644801009875	glycerate dehydrogenase; Provisional; Region: PRK06487
644801009876	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
644801009877	putative ligand binding site [chemical binding]; other site
644801009878	putative NAD binding site [chemical binding]; other site
644801009879	catalytic site [active]
644801009880	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
644801009881	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
644801009882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801009883	S-adenosylmethionine binding site [chemical binding]; other site
644801009884	yybP-ykoY leader; Psest_3225
644801009885	Predicted membrane protein [Function unknown]; Region: COG2119
644801009886	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
644801009887	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
644801009888	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
644801009889	Peptidase family M48; Region: Peptidase_M48; pfam01435
644801009890	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801009891	dimerization interface [polypeptide binding]; other site
644801009892	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801009893	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801009894	dimer interface [polypeptide binding]; other site
644801009895	putative CheW interface [polypeptide binding]; other site
644801009896	Uncharacterized conserved protein [Function unknown]; Region: COG2135
644801009897	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
644801009898	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
644801009899	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
644801009900	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
644801009901	putative acyl-acceptor binding pocket; other site
644801009902	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
644801009903	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
644801009904	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
644801009905	putative transporter; Provisional; Region: PRK11660
644801009906	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
644801009907	Sulfate transporter family; Region: Sulfate_transp; pfam00916
644801009908	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
644801009909	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
644801009910	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
644801009911	NAD binding site [chemical binding]; other site
644801009912	homodimer interface [polypeptide binding]; other site
644801009913	active site
644801009914	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
644801009915	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
644801009916	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
644801009917	SnoaL-like domain; Region: SnoaL_3; pfam13474
644801009918	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
644801009919	MgtC family; Region: MgtC; pfam02308
644801009920	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
644801009921	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
644801009922	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
644801009923	Ferritin-like domain; Region: Ferritin; pfam00210
644801009924	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
644801009925	dinuclear metal binding motif [ion binding]; other site
644801009926	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
644801009927	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
644801009928	cell division protein FtsZ; Validated; Region: PRK09330
644801009929	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
644801009930	nucleotide binding site [chemical binding]; other site
644801009931	SulA interaction site; other site
644801009932	cell division protein FtsA; Region: ftsA; TIGR01174
644801009933	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
644801009934	nucleotide binding site [chemical binding]; other site
644801009935	Cell division protein FtsA; Region: FtsA; pfam14450
644801009936	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
644801009937	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
644801009938	Cell division protein FtsQ; Region: FtsQ; pfam03799
644801009939	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
644801009940	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
644801009941	ATP-grasp domain; Region: ATP-grasp_4; cl17255
644801009942	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
644801009943	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
644801009944	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
644801009945	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
644801009946	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
644801009947	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
644801009948	active site
644801009949	homodimer interface [polypeptide binding]; other site
644801009950	cell division protein FtsW; Region: ftsW; TIGR02614
644801009951	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
644801009952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801009953	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
644801009954	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
644801009955	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
644801009956	Mg++ binding site [ion binding]; other site
644801009957	putative catalytic motif [active]
644801009958	putative substrate binding site [chemical binding]; other site
644801009959	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
644801009960	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
644801009961	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
644801009962	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
644801009963	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
644801009964	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
644801009965	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
644801009966	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
644801009967	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
644801009968	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
644801009969	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
644801009970	Cell division protein FtsL; Region: FtsL; pfam04999
644801009971	MraW methylase family; Region: Methyltransf_5; pfam01795
644801009972	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
644801009973	cell division protein MraZ; Reviewed; Region: PRK00326
644801009974	MraZ protein; Region: MraZ; pfam02381
644801009975	MraZ protein; Region: MraZ; pfam02381
644801009976	Predicted methyltransferases [General function prediction only]; Region: COG0313
644801009977	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
644801009978	putative SAM binding site [chemical binding]; other site
644801009979	putative homodimer interface [polypeptide binding]; other site
644801009980	LppC putative lipoprotein; Region: LppC; pfam04348
644801009981	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
644801009982	putative ligand binding site [chemical binding]; other site
644801009983	hypothetical protein; Reviewed; Region: PRK12497
644801009984	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
644801009985	dimer interface [polypeptide binding]; other site
644801009986	active site
644801009987	outer membrane lipoprotein; Provisional; Region: PRK11023
644801009988	BON domain; Region: BON; pfam04972
644801009989	BON domain; Region: BON; pfam04972
644801009990	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
644801009991	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
644801009992	stringent starvation protein A; Provisional; Region: sspA; PRK09481
644801009993	C-terminal domain interface [polypeptide binding]; other site
644801009994	putative GSH binding site (G-site) [chemical binding]; other site
644801009995	dimer interface [polypeptide binding]; other site
644801009996	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
644801009997	dimer interface [polypeptide binding]; other site
644801009998	N-terminal domain interface [polypeptide binding]; other site
644801009999	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
644801010000	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
644801010001	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
644801010002	Qi binding site; other site
644801010003	intrachain domain interface; other site
644801010004	interchain domain interface [polypeptide binding]; other site
644801010005	heme bH binding site [chemical binding]; other site
644801010006	heme bL binding site [chemical binding]; other site
644801010007	Qo binding site; other site
644801010008	interchain domain interface [polypeptide binding]; other site
644801010009	intrachain domain interface; other site
644801010010	Qi binding site; other site
644801010011	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
644801010012	Qo binding site; other site
644801010013	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
644801010014	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
644801010015	[2Fe-2S] cluster binding site [ion binding]; other site
644801010016	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
644801010017	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
644801010018	23S rRNA interface [nucleotide binding]; other site
644801010019	L3 interface [polypeptide binding]; other site
644801010020	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
644801010021	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
644801010022	active site
644801010023	catalytic tetrad [active]
644801010024	Predicted membrane protein [Function unknown]; Region: COG3235
644801010025	DNA gyrase inhibitor; Reviewed; Region: PRK00418
644801010026	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
644801010027	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
644801010028	CoA-binding site [chemical binding]; other site
644801010029	ATP-binding [chemical binding]; other site
644801010030	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
644801010031	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
644801010032	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
644801010033	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
644801010034	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
644801010035	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
644801010036	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
644801010037	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
644801010038	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
644801010039	Walker A motif; other site
644801010040	ATP binding site [chemical binding]; other site
644801010041	Walker B motif; other site
644801010042	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
644801010043	Pilin (bacterial filament); Region: Pilin; pfam00114
644801010044	Pilin (bacterial filament); Region: Pilin; pfam00114
644801010045	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
644801010046	O-Antigen ligase; Region: Wzy_C; pfam04932
644801010047	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
644801010048	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
644801010049	CysD dimerization site [polypeptide binding]; other site
644801010050	G1 box; other site
644801010051	putative GEF interaction site [polypeptide binding]; other site
644801010052	GTP/Mg2+ binding site [chemical binding]; other site
644801010053	Switch I region; other site
644801010054	G2 box; other site
644801010055	G3 box; other site
644801010056	Switch II region; other site
644801010057	G4 box; other site
644801010058	G5 box; other site
644801010059	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
644801010060	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
644801010061	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
644801010062	ligand-binding site [chemical binding]; other site
644801010063	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
644801010064	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
644801010065	Active Sites [active]
644801010066	Uncharacterized conserved protein [Function unknown]; Region: COG0327
644801010067	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
644801010068	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
644801010069	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
644801010070	protein binding site [polypeptide binding]; other site
644801010071	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
644801010072	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
644801010073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801010074	homodimer interface [polypeptide binding]; other site
644801010075	catalytic residue [active]
644801010076	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
644801010077	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
644801010078	NAD binding site [chemical binding]; other site
644801010079	dimerization interface [polypeptide binding]; other site
644801010080	product binding site; other site
644801010081	substrate binding site [chemical binding]; other site
644801010082	zinc binding site [ion binding]; other site
644801010083	catalytic residues [active]
644801010084	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
644801010085	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
644801010086	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
644801010087	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
644801010088	hinge; other site
644801010089	active site
644801010090	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
644801010091	Predicted membrane protein [Function unknown]; Region: COG3223
644801010092	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
644801010093	anti sigma factor interaction site; other site
644801010094	regulatory phosphorylation site [posttranslational modification]; other site
644801010095	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
644801010096	mce related protein; Region: MCE; pfam02470
644801010097	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
644801010098	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
644801010099	conserved hypothetical integral membrane protein; Region: TIGR00056
644801010100	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
644801010101	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
644801010102	Walker A/P-loop; other site
644801010103	ATP binding site [chemical binding]; other site
644801010104	Q-loop/lid; other site
644801010105	ABC transporter signature motif; other site
644801010106	Walker B; other site
644801010107	D-loop; other site
644801010108	H-loop/switch region; other site
644801010109	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
644801010110	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
644801010111	putative active site [active]
644801010112	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
644801010113	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
644801010114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801010115	active site
644801010116	motif I; other site
644801010117	motif II; other site
644801010118	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
644801010119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
644801010120	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
644801010121	OstA-like protein; Region: OstA; pfam03968
644801010122	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
644801010123	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
644801010124	Walker A/P-loop; other site
644801010125	ATP binding site [chemical binding]; other site
644801010126	Q-loop/lid; other site
644801010127	ABC transporter signature motif; other site
644801010128	Walker B; other site
644801010129	D-loop; other site
644801010130	H-loop/switch region; other site
644801010131	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
644801010132	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
644801010133	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
644801010134	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
644801010135	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
644801010136	30S subunit binding site; other site
644801010137	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
644801010138	active site
644801010139	phosphorylation site [posttranslational modification]
644801010140	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
644801010141	AAA domain; Region: AAA_18; pfam13238
644801010142	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
644801010143	dimerization domain swap beta strand [polypeptide binding]; other site
644801010144	regulatory protein interface [polypeptide binding]; other site
644801010145	active site
644801010146	regulatory phosphorylation site [posttranslational modification]; other site
644801010147	peptidase PmbA; Provisional; Region: PRK11040
644801010148	hypothetical protein; Provisional; Region: PRK05255
644801010149	protease TldD; Provisional; Region: tldD; PRK10735
644801010150	nitrilase; Region: PLN02798
644801010151	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
644801010152	putative active site [active]
644801010153	catalytic triad [active]
644801010154	dimer interface [polypeptide binding]; other site
644801010155	TIGR02099 family protein; Region: TIGR02099
644801010156	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
644801010157	ribonuclease G; Provisional; Region: PRK11712
644801010158	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
644801010159	homodimer interface [polypeptide binding]; other site
644801010160	oligonucleotide binding site [chemical binding]; other site
644801010161	Maf-like protein; Region: Maf; pfam02545
644801010162	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
644801010163	active site
644801010164	dimer interface [polypeptide binding]; other site
644801010165	rod shape-determining protein MreD; Region: MreD; cl01087
644801010166	rod shape-determining protein MreC; Provisional; Region: PRK13922
644801010167	rod shape-determining protein MreC; Region: MreC; pfam04085
644801010168	rod shape-determining protein MreB; Provisional; Region: PRK13927
644801010169	MreB and similar proteins; Region: MreB_like; cd10225
644801010170	nucleotide binding site [chemical binding]; other site
644801010171	Mg binding site [ion binding]; other site
644801010172	putative protofilament interaction site [polypeptide binding]; other site
644801010173	RodZ interaction site [polypeptide binding]; other site
644801010174	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
644801010175	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
644801010176	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
644801010177	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
644801010178	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
644801010179	GatB domain; Region: GatB_Yqey; smart00845
644801010180	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
644801010181	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
644801010182	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
644801010183	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
644801010184	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
644801010185	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
644801010186	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
644801010187	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
644801010188	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
644801010189	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
644801010190	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801010191	Predicted permeases [General function prediction only]; Region: COG0679
644801010192	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
644801010193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801010194	active site
644801010195	phosphorylation site [posttranslational modification]
644801010196	intermolecular recognition site; other site
644801010197	dimerization interface [polypeptide binding]; other site
644801010198	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801010199	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801010200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801010201	ATP binding site [chemical binding]; other site
644801010202	G-X-G motif; other site
644801010203	Protein of unknown function (DUF541); Region: SIMPL; cl01077
644801010204	Uncharacterized conserved protein [Function unknown]; Region: COG2968
644801010205	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
644801010206	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801010207	N-terminal plug; other site
644801010208	ligand-binding site [chemical binding]; other site
644801010209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
644801010210	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
644801010211	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
644801010212	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
644801010213	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
644801010214	Flavodoxin; Region: Flavodoxin_1; pfam00258
644801010215	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
644801010216	FAD binding pocket [chemical binding]; other site
644801010217	FAD binding motif [chemical binding]; other site
644801010218	catalytic residues [active]
644801010219	NAD binding pocket [chemical binding]; other site
644801010220	phosphate binding motif [ion binding]; other site
644801010221	beta-alpha-beta structure motif; other site
644801010222	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
644801010223	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801010224	N-terminal plug; other site
644801010225	ligand-binding site [chemical binding]; other site
644801010226	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
644801010227	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801010228	N-terminal plug; other site
644801010229	ligand-binding site [chemical binding]; other site
644801010230	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
644801010231	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
644801010232	Sel1 repeat; Region: Sel1; cl02723
644801010233	Sel1-like repeats; Region: SEL1; smart00671
644801010234	Sel1-like repeats; Region: SEL1; smart00671
644801010235	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
644801010236	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
644801010237	dimer interface [polypeptide binding]; other site
644801010238	active site
644801010239	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
644801010240	catalytic residues [active]
644801010241	substrate binding site [chemical binding]; other site
644801010242	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
644801010243	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
644801010244	G1 box; other site
644801010245	putative GEF interaction site [polypeptide binding]; other site
644801010246	GTP/Mg2+ binding site [chemical binding]; other site
644801010247	Switch I region; other site
644801010248	G2 box; other site
644801010249	G3 box; other site
644801010250	Switch II region; other site
644801010251	G4 box; other site
644801010252	G5 box; other site
644801010253	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
644801010254	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
644801010255	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
644801010256	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
644801010257	active site
644801010258	P-loop; other site
644801010259	phosphorylation site [posttranslational modification]
644801010260	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
644801010261	active site
644801010262	P-loop; other site
644801010263	phosphorylation site [posttranslational modification]
644801010264	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
644801010265	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
644801010266	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
644801010267	putative substrate binding site [chemical binding]; other site
644801010268	putative ATP binding site [chemical binding]; other site
644801010269	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
644801010270	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
644801010271	active site
644801010272	phosphorylation site [posttranslational modification]
644801010273	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
644801010274	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
644801010275	dimerization domain swap beta strand [polypeptide binding]; other site
644801010276	regulatory protein interface [polypeptide binding]; other site
644801010277	active site
644801010278	regulatory phosphorylation site [posttranslational modification]; other site
644801010279	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
644801010280	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
644801010281	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
644801010282	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
644801010283	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
644801010284	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
644801010285	DNA binding site [nucleotide binding]
644801010286	domain linker motif; other site
644801010287	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
644801010288	dimerization interface [polypeptide binding]; other site
644801010289	ligand binding site [chemical binding]; other site
644801010290	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
644801010291	homodimer interface [polypeptide binding]; other site
644801010292	chemical substrate binding site [chemical binding]; other site
644801010293	oligomer interface [polypeptide binding]; other site
644801010294	metal binding site [ion binding]; metal-binding site
644801010295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801010296	S-adenosylmethionine binding site [chemical binding]; other site
644801010297	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
644801010298	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
644801010299	Protein of unknown function, DUF606; Region: DUF606; pfam04657
644801010300	SdiA-regulated; Region: SdiA-regulated; pfam06977
644801010301	SdiA-regulated; Region: SdiA-regulated; cd09971
644801010302	putative active site [active]
644801010303	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
644801010304	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
644801010305	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
644801010306	arginine decarboxylase; Provisional; Region: PRK05354
644801010307	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
644801010308	dimer interface [polypeptide binding]; other site
644801010309	active site
644801010310	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
644801010311	catalytic residues [active]
644801010312	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
644801010313	translation initiation factor Sui1; Validated; Region: PRK06824
644801010314	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
644801010315	putative rRNA binding site [nucleotide binding]; other site
644801010316	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
644801010317	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
644801010318	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
644801010319	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
644801010320	Type II transport protein GspH; Region: GspH; pfam12019
644801010321	Type II transport protein GspH; Region: GspH; pfam12019
644801010322	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
644801010323	Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633
644801010324	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
644801010325	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
644801010326	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
644801010327	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
644801010328	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
644801010329	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
644801010330	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
644801010331	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
644801010332	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
644801010333	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
644801010334	lipoprotein signal peptidase; Provisional; Region: PRK14787
644801010335	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
644801010336	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
644801010337	active site
644801010338	HIGH motif; other site
644801010339	nucleotide binding site [chemical binding]; other site
644801010340	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
644801010341	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
644801010342	active site
644801010343	KMSKS motif; other site
644801010344	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
644801010345	tRNA binding surface [nucleotide binding]; other site
644801010346	anticodon binding site; other site
644801010347	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
644801010348	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
644801010349	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
644801010350	active site
644801010351	Riboflavin kinase; Region: Flavokinase; smart00904
644801010352	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
644801010353	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
644801010354	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
644801010355	hypothetical protein; Provisional; Region: PRK10756
644801010356	CreA protein; Region: CreA; pfam05981
644801010357	gamma-glutamyl kinase; Provisional; Region: PRK05429
644801010358	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
644801010359	nucleotide binding site [chemical binding]; other site
644801010360	homotetrameric interface [polypeptide binding]; other site
644801010361	putative phosphate binding site [ion binding]; other site
644801010362	putative allosteric binding site; other site
644801010363	PUA domain; Region: PUA; pfam01472
644801010364	GTPase CgtA; Reviewed; Region: obgE; PRK12298
644801010365	GTP1/OBG; Region: GTP1_OBG; pfam01018
644801010366	Obg GTPase; Region: Obg; cd01898
644801010367	G1 box; other site
644801010368	GTP/Mg2+ binding site [chemical binding]; other site
644801010369	Switch I region; other site
644801010370	G2 box; other site
644801010371	G3 box; other site
644801010372	Switch II region; other site
644801010373	G4 box; other site
644801010374	G5 box; other site
644801010375	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
644801010376	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
644801010377	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
644801010378	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
644801010379	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
644801010380	substrate binding pocket [chemical binding]; other site
644801010381	chain length determination region; other site
644801010382	substrate-Mg2+ binding site; other site
644801010383	catalytic residues [active]
644801010384	aspartate-rich region 1; other site
644801010385	active site lid residues [active]
644801010386	aspartate-rich region 2; other site
644801010387	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
644801010388	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
644801010389	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
644801010390	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
644801010391	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
644801010392	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
644801010393	hypothetical protein; Provisional; Region: PRK05208
644801010394	AAA domain; Region: AAA_32; pfam13654
644801010395	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
644801010396	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
644801010397	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
644801010398	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
644801010399	Protein of unknown function (DUF465); Region: DUF465; cl01070
644801010400	DNA repair protein RadA; Provisional; Region: PRK11823
644801010401	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
644801010402	Walker A motif; other site
644801010403	ATP binding site [chemical binding]; other site
644801010404	Walker B motif; other site
644801010405	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
644801010406	PilZ domain; Region: PilZ; pfam07238
644801010407	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
644801010408	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
644801010409	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
644801010410	dimer interface [polypeptide binding]; other site
644801010411	active site
644801010412	glycine-pyridoxal phosphate binding site [chemical binding]; other site
644801010413	folate binding site [chemical binding]; other site
644801010414	HsdM N-terminal domain; Region: HsdM_N; pfam12161
644801010415	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
644801010416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801010417	S-adenosylmethionine binding site [chemical binding]; other site
644801010418	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
644801010419	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
644801010420	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
644801010421	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
644801010422	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
644801010423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801010424	non-specific DNA binding site [nucleotide binding]; other site
644801010425	salt bridge; other site
644801010426	sequence-specific DNA binding site [nucleotide binding]; other site
644801010427	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
644801010428	helicase superfamily c-terminal domain; Region: HELICc; smart00490
644801010429	putative transposase OrfB; Reviewed; Region: PHA02517
644801010430	HTH-like domain; Region: HTH_21; pfam13276
644801010431	Integrase core domain; Region: rve; pfam00665
644801010432	Integrase core domain; Region: rve_2; pfam13333
644801010433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
644801010434	Transposase; Region: HTH_Tnp_1; pfam01527
644801010435	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801010436	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
644801010437	Walker A motif; other site
644801010438	ATP binding site [chemical binding]; other site
644801010439	Walker B motif; other site
644801010440	arginine finger; other site
644801010441	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
644801010442	active site
644801010443	NTP binding site [chemical binding]; other site
644801010444	metal binding triad [ion binding]; metal-binding site
644801010445	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
644801010446	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801010447	non-specific DNA binding site [nucleotide binding]; other site
644801010448	salt bridge; other site
644801010449	sequence-specific DNA binding site [nucleotide binding]; other site
644801010450	Domain of unknown function (DUF955); Region: DUF955; pfam06114
644801010451	Integral membrane protein TerC family; Region: TerC; cl10468
644801010452	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801010453	active site
644801010454	DNA binding site [nucleotide binding]
644801010455	Int/Topo IB signature motif; other site
644801010456	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
644801010457	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801010458	Coenzyme A binding pocket [chemical binding]; other site
644801010459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
644801010460	Transposase domain (DUF772); Region: DUF772; pfam05598
644801010461	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
644801010462	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
644801010463	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801010464	active site
644801010465	Int/Topo IB signature motif; other site
644801010466	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801010467	active site
644801010468	Int/Topo IB signature motif; other site
644801010469	catalytic residues [active]
644801010470	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
644801010471	active site
644801010472	catalytic residues [active]
644801010473	Int/Topo IB signature motif; other site
644801010474	DNA binding site [nucleotide binding]
644801010475	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
644801010476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801010477	Walker A/P-loop; other site
644801010478	ATP binding site [chemical binding]; other site
644801010479	Q-loop/lid; other site
644801010480	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801010481	ABC transporter signature motif; other site
644801010482	Walker B; other site
644801010483	D-loop; other site
644801010484	ABC transporter; Region: ABC_tran_2; pfam12848
644801010485	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801010486	Cache domain; Region: Cache_1; pfam02743
644801010487	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
644801010488	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
644801010489	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
644801010490	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
644801010491	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801010492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801010493	metal binding site [ion binding]; metal-binding site
644801010494	active site
644801010495	I-site; other site
644801010496	glutamate dehydrogenase; Provisional; Region: PRK09414
644801010497	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
644801010498	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
644801010499	NAD(P) binding site [chemical binding]; other site
644801010500	ferredoxin-NADP reductase; Provisional; Region: PRK10926
644801010501	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
644801010502	FAD binding pocket [chemical binding]; other site
644801010503	FAD binding motif [chemical binding]; other site
644801010504	phosphate binding motif [ion binding]; other site
644801010505	beta-alpha-beta structure motif; other site
644801010506	NAD binding pocket [chemical binding]; other site
644801010507	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
644801010508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801010509	S-adenosylmethionine binding site [chemical binding]; other site
644801010510	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
644801010511	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
644801010512	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
644801010513	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
644801010514	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
644801010515	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
644801010516	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
644801010517	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
644801010518	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
644801010519	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
644801010520	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
644801010521	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
644801010522	Ligand binding site; other site
644801010523	metal-binding site
644801010524	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
644801010525	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
644801010526	XdhC Rossmann domain; Region: XdhC_C; pfam13478
644801010527	DJ-1 family protein; Region: not_thiJ; TIGR01383
644801010528	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
644801010529	conserved cys residue [active]
644801010530	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
644801010531	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
644801010532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801010533	S-adenosylmethionine binding site [chemical binding]; other site
644801010534	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
644801010535	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801010536	active site residue [active]
644801010537	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
644801010538	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
644801010539	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
644801010540	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
644801010541	FAD binding pocket [chemical binding]; other site
644801010542	FAD binding motif [chemical binding]; other site
644801010543	phosphate binding motif [ion binding]; other site
644801010544	beta-alpha-beta structure motif; other site
644801010545	NAD(p) ribose binding residues [chemical binding]; other site
644801010546	NAD binding pocket [chemical binding]; other site
644801010547	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
644801010548	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801010549	catalytic loop [active]
644801010550	iron binding site [ion binding]; other site
644801010551	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
644801010552	Dihaem cytochrome c; Region: DHC; pfam09626
644801010553	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
644801010554	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801010555	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801010556	DNA binding residues [nucleotide binding]
644801010557	Putative zinc-finger; Region: zf-HC2; pfam13490
644801010558	Heavy-metal resistance; Region: Metal_resist; pfam13801
644801010559	dimer interface [polypeptide binding]; other site
644801010560	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
644801010561	Sulfatase; Region: Sulfatase; pfam00884
644801010562	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
644801010563	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
644801010564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801010565	S-adenosylmethionine binding site [chemical binding]; other site
644801010566	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801010567	HAMP domain; Region: HAMP; pfam00672
644801010568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801010569	dimer interface [polypeptide binding]; other site
644801010570	phosphorylation site [posttranslational modification]
644801010571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801010572	ATP binding site [chemical binding]; other site
644801010573	Mg2+ binding site [ion binding]; other site
644801010574	G-X-G motif; other site
644801010575	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
644801010576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801010577	active site
644801010578	phosphorylation site [posttranslational modification]
644801010579	intermolecular recognition site; other site
644801010580	dimerization interface [polypeptide binding]; other site
644801010581	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801010582	DNA binding site [nucleotide binding]
644801010583	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
644801010584	Sulfatase; Region: Sulfatase; pfam00884
644801010585	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
644801010586	active site
644801010587	SdiA-regulated; Region: SdiA-regulated; pfam06977
644801010588	SdiA-regulated; Region: SdiA-regulated; cd09971
644801010589	putative active site [active]
644801010590	Uncharacterized conserved protein [Function unknown]; Region: COG3339
644801010591	Thermostable hemolysin; Region: T_hemolysin; pfam12261
644801010592	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
644801010593	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
644801010594	acyl-activating enzyme (AAE) consensus motif; other site
644801010595	putative AMP binding site [chemical binding]; other site
644801010596	putative active site [active]
644801010597	putative CoA binding site [chemical binding]; other site
644801010598	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
644801010599	heme binding pocket [chemical binding]; other site
644801010600	heme ligand [chemical binding]; other site
644801010601	short chain dehydrogenase; Provisional; Region: PRK09072
644801010602	classical (c) SDRs; Region: SDR_c; cd05233
644801010603	NAD(P) binding site [chemical binding]; other site
644801010604	active site
644801010605	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801010606	TPR motif; other site
644801010607	binding surface
644801010608	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
644801010609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801010610	active site
644801010611	phosphorylation site [posttranslational modification]
644801010612	intermolecular recognition site; other site
644801010613	dimerization interface [polypeptide binding]; other site
644801010614	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801010615	DNA binding site [nucleotide binding]
644801010616	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
644801010617	dimer interface [polypeptide binding]; other site
644801010618	phosphorylation site [posttranslational modification]
644801010619	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801010620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801010621	ATP binding site [chemical binding]; other site
644801010622	Mg2+ binding site [ion binding]; other site
644801010623	G-X-G motif; other site
644801010624	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
644801010625	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
644801010626	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
644801010627	dimer interface [polypeptide binding]; other site
644801010628	putative functional site; other site
644801010629	putative MPT binding site; other site
644801010630	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
644801010631	MPT binding site; other site
644801010632	trimer interface [polypeptide binding]; other site
644801010633	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
644801010634	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801010635	FeS/SAM binding site; other site
644801010636	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
644801010637	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
644801010638	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
644801010639	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
644801010640	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
644801010641	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
644801010642	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
644801010643	[4Fe-4S] binding site [ion binding]; other site
644801010644	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801010645	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801010646	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801010647	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
644801010648	molybdopterin cofactor binding site; other site
644801010649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801010650	putative substrate translocation pore; other site
644801010651	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801010652	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801010653	Ligand Binding Site [chemical binding]; other site
644801010654	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
644801010655	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
644801010656	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
644801010657	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
644801010658	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801010659	dimerization interface [polypeptide binding]; other site
644801010660	Histidine kinase; Region: HisKA_3; pfam07730
644801010661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801010662	ATP binding site [chemical binding]; other site
644801010663	Mg2+ binding site [ion binding]; other site
644801010664	G-X-G motif; other site
644801010665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801010666	active site
644801010667	phosphorylation site [posttranslational modification]
644801010668	intermolecular recognition site; other site
644801010669	dimerization interface [polypeptide binding]; other site
644801010670	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801010671	DNA binding residues [nucleotide binding]
644801010672	dimerization interface [polypeptide binding]; other site
644801010673	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
644801010674	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
644801010675	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801010676	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801010677	ligand binding site [chemical binding]; other site
644801010678	flexible hinge region; other site
644801010679	putative switch regulator; other site
644801010680	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
644801010681	non-specific DNA interactions [nucleotide binding]; other site
644801010682	DNA binding site [nucleotide binding]
644801010683	sequence specific DNA binding site [nucleotide binding]; other site
644801010684	putative cAMP binding site [chemical binding]; other site
644801010685	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
644801010686	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801010687	ligand binding site [chemical binding]; other site
644801010688	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
644801010689	putative switch regulator; other site
644801010690	non-specific DNA interactions [nucleotide binding]; other site
644801010691	DNA binding site [nucleotide binding]
644801010692	sequence specific DNA binding site [nucleotide binding]; other site
644801010693	putative cAMP binding site [chemical binding]; other site
644801010694	Predicted metal-binding protein [General function prediction only]; Region: COG3019
644801010695	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
644801010696	Predicted metalloprotease [General function prediction only]; Region: COG2321
644801010697	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801010698	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
644801010699	active site
644801010700	motif I; other site
644801010701	motif II; other site
644801010702	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
644801010703	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
644801010704	active site
644801010705	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
644801010706	catalytic triad [active]
644801010707	dimer interface [polypeptide binding]; other site
644801010708	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
644801010709	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
644801010710	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
644801010711	putative active site [active]
644801010712	Zn binding site [ion binding]; other site
644801010713	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
644801010714	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
644801010715	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
644801010716	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
644801010717	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
644801010718	DEAD-like helicases superfamily; Region: DEXDc; smart00487
644801010719	ATP binding site [chemical binding]; other site
644801010720	Mg++ binding site [ion binding]; other site
644801010721	motif III; other site
644801010722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801010723	nucleotide binding region [chemical binding]; other site
644801010724	ATP-binding site [chemical binding]; other site
644801010725	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
644801010726	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
644801010727	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
644801010728	TrkA-N domain; Region: TrkA_N; pfam02254
644801010729	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801010730	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
644801010731	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
644801010732	potential catalytic triad [active]
644801010733	conserved cys residue [active]
644801010734	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
644801010735	Cache domain; Region: Cache_1; pfam02743
644801010736	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801010737	dimerization interface [polypeptide binding]; other site
644801010738	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801010739	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801010740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801010741	dimer interface [polypeptide binding]; other site
644801010742	putative CheW interface [polypeptide binding]; other site
644801010743	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
644801010744	Na2 binding site [ion binding]; other site
644801010745	putative substrate binding site 1 [chemical binding]; other site
644801010746	Na binding site 1 [ion binding]; other site
644801010747	putative substrate binding site 2 [chemical binding]; other site
644801010748	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
644801010749	maleylacetoacetate isomerase; Region: maiA; TIGR01262
644801010750	C-terminal domain interface [polypeptide binding]; other site
644801010751	GSH binding site (G-site) [chemical binding]; other site
644801010752	putative dimer interface [polypeptide binding]; other site
644801010753	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
644801010754	dimer interface [polypeptide binding]; other site
644801010755	N-terminal domain interface [polypeptide binding]; other site
644801010756	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
644801010757	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
644801010758	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
644801010759	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
644801010760	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
644801010761	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
644801010762	dimer interface [polypeptide binding]; other site
644801010763	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
644801010764	active site
644801010765	Fe binding site [ion binding]; other site
644801010766	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
644801010767	Na2 binding site [ion binding]; other site
644801010768	putative substrate binding site 1 [chemical binding]; other site
644801010769	Na binding site 1 [ion binding]; other site
644801010770	putative substrate binding site 2 [chemical binding]; other site
644801010771	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
644801010772	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
644801010773	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
644801010774	NAD binding site [chemical binding]; other site
644801010775	Phe binding site; other site
644801010776	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
644801010777	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
644801010778	dimer interface [polypeptide binding]; other site
644801010779	PYR/PP interface [polypeptide binding]; other site
644801010780	TPP binding site [chemical binding]; other site
644801010781	substrate binding site [chemical binding]; other site
644801010782	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
644801010783	TPP-binding site [chemical binding]; other site
644801010784	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
644801010785	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801010786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801010787	putative DNA binding site [nucleotide binding]; other site
644801010788	putative Zn2+ binding site [ion binding]; other site
644801010789	AsnC family; Region: AsnC_trans_reg; pfam01037
644801010790	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
644801010791	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
644801010792	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
644801010793	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
644801010794	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
644801010795	NAD binding site [chemical binding]; other site
644801010796	homotetramer interface [polypeptide binding]; other site
644801010797	homodimer interface [polypeptide binding]; other site
644801010798	substrate binding site [chemical binding]; other site
644801010799	active site
644801010800	thymidine phosphorylase; Provisional; Region: PRK04350
644801010801	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
644801010802	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
644801010803	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
644801010804	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
644801010805	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
644801010806	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801010807	active site
644801010808	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
644801010809	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974
644801010810	putative DNA binding site [nucleotide binding]; other site
644801010811	catalytic residue [active]
644801010812	putative H2TH interface [polypeptide binding]; other site
644801010813	putative catalytic residues [active]
644801010814	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
644801010815	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
644801010816	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
644801010817	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
644801010818	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
644801010819	probable active site [active]
644801010820	Predicted membrane protein [Function unknown]; Region: COG3212
644801010821	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
644801010822	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
644801010823	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
644801010824	Predicted membrane protein [Function unknown]; Region: COG3212
644801010825	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
644801010826	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
644801010827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801010828	active site
644801010829	phosphorylation site [posttranslational modification]
644801010830	intermolecular recognition site; other site
644801010831	dimerization interface [polypeptide binding]; other site
644801010832	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801010833	DNA binding site [nucleotide binding]
644801010834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801010835	ATP binding site [chemical binding]; other site
644801010836	Mg2+ binding site [ion binding]; other site
644801010837	G-X-G motif; other site
644801010838	WYL domain; Region: WYL; pfam13280
644801010839	exonuclease subunit SbcD; Provisional; Region: PRK10966
644801010840	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
644801010841	active site
644801010842	metal binding site [ion binding]; metal-binding site
644801010843	DNA binding site [nucleotide binding]
644801010844	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
644801010845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801010846	Walker A/P-loop; other site
644801010847	ATP binding site [chemical binding]; other site
644801010848	Q-loop/lid; other site
644801010849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801010850	ABC transporter signature motif; other site
644801010851	Walker B; other site
644801010852	D-loop; other site
644801010853	H-loop/switch region; other site
644801010854	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
644801010855	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801010856	N-terminal plug; other site
644801010857	ligand-binding site [chemical binding]; other site
644801010858	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
644801010859	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
644801010860	cobalamin binding residues [chemical binding]; other site
644801010861	putative BtuC binding residues; other site
644801010862	dimer interface [polypeptide binding]; other site
644801010863	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
644801010864	dimerization interface [polypeptide binding]; other site
644801010865	active site
644801010866	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
644801010867	catalytic motif [active]
644801010868	Catalytic residue [active]
644801010869	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
644801010870	tetramer interfaces [polypeptide binding]; other site
644801010871	binuclear metal-binding site [ion binding]; other site
644801010872	thiamine monophosphate kinase; Provisional; Region: PRK05731
644801010873	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
644801010874	ATP binding site [chemical binding]; other site
644801010875	dimerization interface [polypeptide binding]; other site
644801010876	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
644801010877	putative RNA binding site [nucleotide binding]; other site
644801010878	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
644801010879	homopentamer interface [polypeptide binding]; other site
644801010880	active site
644801010881	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
644801010882	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
644801010883	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
644801010884	dimerization interface [polypeptide binding]; other site
644801010885	active site
644801010886	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
644801010887	Lumazine binding domain; Region: Lum_binding; pfam00677
644801010888	Lumazine binding domain; Region: Lum_binding; pfam00677
644801010889	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
644801010890	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
644801010891	catalytic motif [active]
644801010892	Zn binding site [ion binding]; other site
644801010893	RibD C-terminal domain; Region: RibD_C; cl17279
644801010894	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
644801010895	ATP cone domain; Region: ATP-cone; pfam03477
644801010896	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
644801010897	Predicted methyltransferase [General function prediction only]; Region: COG3897
644801010898	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
644801010899	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
644801010900	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
644801010901	hypothetical protein; Provisional; Region: PRK11018
644801010902	CPxP  motif; other site
644801010903	putative inner membrane protein; Provisional; Region: PRK11099
644801010904	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
644801010905	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
644801010906	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
644801010907	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
644801010908	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
644801010909	Walker A/P-loop; other site
644801010910	ATP binding site [chemical binding]; other site
644801010911	Q-loop/lid; other site
644801010912	ABC transporter signature motif; other site
644801010913	Walker B; other site
644801010914	D-loop; other site
644801010915	H-loop/switch region; other site
644801010916	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
644801010917	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
644801010918	FtsX-like permease family; Region: FtsX; pfam02687
644801010919	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
644801010920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
644801010921	binding surface
644801010922	TPR motif; other site
644801010923	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
644801010924	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
644801010925	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
644801010926	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
644801010927	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
644801010928	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
644801010929	OmpW family; Region: OmpW; cl17427
644801010930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801010931	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
644801010932	NAD(P) binding site [chemical binding]; other site
644801010933	active site
644801010934	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
644801010935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801010936	NAD(P) binding site [chemical binding]; other site
644801010937	active site
644801010938	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
644801010939	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
644801010940	dimer interface [polypeptide binding]; other site
644801010941	ssDNA binding site [nucleotide binding]; other site
644801010942	tetramer (dimer of dimers) interface [polypeptide binding]; other site
644801010943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801010944	Major Facilitator Superfamily; Region: MFS_1; pfam07690
644801010945	putative substrate translocation pore; other site
644801010946	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
644801010947	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
644801010948	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
644801010949	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
644801010950	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
644801010951	active site
644801010952	Zn binding site [ion binding]; other site
644801010953	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
644801010954	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
644801010955	tetramer interface [polypeptide binding]; other site
644801010956	heme binding pocket [chemical binding]; other site
644801010957	NADPH binding site [chemical binding]; other site
644801010958	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
644801010959	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
644801010960	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
644801010961	alphaNTD homodimer interface [polypeptide binding]; other site
644801010962	alphaNTD - beta interaction site [polypeptide binding]; other site
644801010963	alphaNTD - beta' interaction site [polypeptide binding]; other site
644801010964	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
644801010965	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
644801010966	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
644801010967	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801010968	RNA binding surface [nucleotide binding]; other site
644801010969	30S ribosomal protein S11; Validated; Region: PRK05309
644801010970	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
644801010971	30S ribosomal protein S13; Region: bact_S13; TIGR03631
644801010972	Alpha operon ribosome binding site; Psest_3584
644801010973	Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257
644801010974	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
644801010975	SecY translocase; Region: SecY; pfam00344
644801010976	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
644801010977	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
644801010978	23S rRNA binding site [nucleotide binding]; other site
644801010979	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
644801010980	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
644801010981	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
644801010982	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
644801010983	5S rRNA interface [nucleotide binding]; other site
644801010984	23S rRNA interface [nucleotide binding]; other site
644801010985	L5 interface [polypeptide binding]; other site
644801010986	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
644801010987	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
644801010988	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
644801010989	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
644801010990	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
644801010991	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
644801010992	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
644801010993	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
644801010994	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
644801010995	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
644801010996	RNA binding site [nucleotide binding]; other site
644801010997	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
644801010998	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
644801010999	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
644801011000	23S rRNA interface [nucleotide binding]; other site
644801011001	putative translocon interaction site; other site
644801011002	signal recognition particle (SRP54) interaction site; other site
644801011003	L23 interface [polypeptide binding]; other site
644801011004	trigger factor interaction site; other site
644801011005	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
644801011006	23S rRNA interface [nucleotide binding]; other site
644801011007	5S rRNA interface [nucleotide binding]; other site
644801011008	putative antibiotic binding site [chemical binding]; other site
644801011009	L25 interface [polypeptide binding]; other site
644801011010	L27 interface [polypeptide binding]; other site
644801011011	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
644801011012	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
644801011013	G-X-X-G motif; other site
644801011014	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
644801011015	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
644801011016	protein-rRNA interface [nucleotide binding]; other site
644801011017	putative translocon binding site; other site
644801011018	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
644801011019	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
644801011020	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
644801011021	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
644801011022	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
644801011023	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
644801011024	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
644801011025	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
644801011026	elongation factor Tu; Reviewed; Region: PRK00049
644801011027	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
644801011028	G1 box; other site
644801011029	GEF interaction site [polypeptide binding]; other site
644801011030	GTP/Mg2+ binding site [chemical binding]; other site
644801011031	Switch I region; other site
644801011032	G2 box; other site
644801011033	G3 box; other site
644801011034	Switch II region; other site
644801011035	G4 box; other site
644801011036	G5 box; other site
644801011037	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
644801011038	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
644801011039	Antibiotic Binding Site [chemical binding]; other site
644801011040	elongation factor G; Reviewed; Region: PRK00007
644801011041	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
644801011042	G1 box; other site
644801011043	putative GEF interaction site [polypeptide binding]; other site
644801011044	GTP/Mg2+ binding site [chemical binding]; other site
644801011045	Switch I region; other site
644801011046	G2 box; other site
644801011047	G3 box; other site
644801011048	Switch II region; other site
644801011049	G4 box; other site
644801011050	G5 box; other site
644801011051	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
644801011052	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
644801011053	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
644801011054	30S ribosomal protein S7; Validated; Region: PRK05302
644801011055	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
644801011056	S17 interaction site [polypeptide binding]; other site
644801011057	S8 interaction site; other site
644801011058	16S rRNA interaction site [nucleotide binding]; other site
644801011059	streptomycin interaction site [chemical binding]; other site
644801011060	23S rRNA interaction site [nucleotide binding]; other site
644801011061	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
644801011062	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
644801011063	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
644801011064	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
644801011065	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
644801011066	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
644801011067	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
644801011068	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
644801011069	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
644801011070	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
644801011071	DNA binding site [nucleotide binding]
644801011072	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
644801011073	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
644801011074	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
644801011075	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
644801011076	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
644801011077	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
644801011078	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
644801011079	RPB3 interaction site [polypeptide binding]; other site
644801011080	RPB1 interaction site [polypeptide binding]; other site
644801011081	RPB11 interaction site [polypeptide binding]; other site
644801011082	RPB10 interaction site [polypeptide binding]; other site
644801011083	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
644801011084	core dimer interface [polypeptide binding]; other site
644801011085	peripheral dimer interface [polypeptide binding]; other site
644801011086	L10 interface [polypeptide binding]; other site
644801011087	L11 interface [polypeptide binding]; other site
644801011088	putative EF-Tu interaction site [polypeptide binding]; other site
644801011089	putative EF-G interaction site [polypeptide binding]; other site
644801011090	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
644801011091	23S rRNA interface [nucleotide binding]; other site
644801011092	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
644801011093	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
644801011094	mRNA/rRNA interface [nucleotide binding]; other site
644801011095	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
644801011096	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
644801011097	23S rRNA interface [nucleotide binding]; other site
644801011098	L7/L12 interface [polypeptide binding]; other site
644801011099	putative thiostrepton binding site; other site
644801011100	L25 interface [polypeptide binding]; other site
644801011101	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
644801011102	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
644801011103	putative homodimer interface [polypeptide binding]; other site
644801011104	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
644801011105	heterodimer interface [polypeptide binding]; other site
644801011106	homodimer interface [polypeptide binding]; other site
644801011107	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
644801011108	elongation factor Tu; Reviewed; Region: PRK00049
644801011109	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
644801011110	G1 box; other site
644801011111	GEF interaction site [polypeptide binding]; other site
644801011112	GTP/Mg2+ binding site [chemical binding]; other site
644801011113	Switch I region; other site
644801011114	G2 box; other site
644801011115	G3 box; other site
644801011116	Switch II region; other site
644801011117	G4 box; other site
644801011118	G5 box; other site
644801011119	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
644801011120	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
644801011121	Antibiotic Binding Site [chemical binding]; other site
644801011122	Sporulation related domain; Region: SPOR; cl10051
644801011123	Sporulation related domain; Region: SPOR; cl10051
644801011124	pantothenate kinase; Reviewed; Region: PRK13322
644801011125	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
644801011126	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801011127	putative Zn2+ binding site [ion binding]; other site
644801011128	putative DNA binding site [nucleotide binding]; other site
644801011129	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
644801011130	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
644801011131	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
644801011132	active site
644801011133	HIGH motif; other site
644801011134	dimer interface [polypeptide binding]; other site
644801011135	KMSKS motif; other site
644801011136	putative peptidase; Provisional; Region: PRK11649
644801011137	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
644801011138	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801011139	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
644801011140	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
644801011141	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
644801011142	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
644801011143	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
644801011144	Protein of unknown function (DUF805); Region: DUF805; pfam05656
644801011145	Ycf46; Provisional; Region: ycf46; CHL00195
644801011146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801011147	Walker A motif; other site
644801011148	ATP binding site [chemical binding]; other site
644801011149	Walker B motif; other site
644801011150	arginine finger; other site
644801011151	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
644801011152	nucleotide binding site/active site [active]
644801011153	HIT family signature motif; other site
644801011154	catalytic residue [active]
644801011155	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
644801011156	diiron binding motif [ion binding]; other site
644801011157	OsmC-like protein; Region: OsmC; cl00767
644801011158	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
644801011159	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
644801011160	ligand binding site [chemical binding]; other site
644801011161	flexible hinge region; other site
644801011162	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
644801011163	putative switch regulator; other site
644801011164	non-specific DNA interactions [nucleotide binding]; other site
644801011165	DNA binding site [nucleotide binding]
644801011166	sequence specific DNA binding site [nucleotide binding]; other site
644801011167	putative cAMP binding site [chemical binding]; other site
644801011168	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
644801011169	active site
644801011170	ribulose/triose binding site [chemical binding]; other site
644801011171	phosphate binding site [ion binding]; other site
644801011172	substrate (anthranilate) binding pocket [chemical binding]; other site
644801011173	product (indole) binding pocket [chemical binding]; other site
644801011174	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
644801011175	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
644801011176	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
644801011177	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
644801011178	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
644801011179	glutamine binding [chemical binding]; other site
644801011180	catalytic triad [active]
644801011181	anthranilate synthase component I; Provisional; Region: PRK13565
644801011182	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
644801011183	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
644801011184	phosphoglycolate phosphatase; Provisional; Region: PRK13222
644801011185	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801011186	motif II; other site
644801011187	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
644801011188	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
644801011189	substrate binding site [chemical binding]; other site
644801011190	hexamer interface [polypeptide binding]; other site
644801011191	metal binding site [ion binding]; metal-binding site
644801011192	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
644801011193	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801011194	inhibitor-cofactor binding pocket; inhibition site
644801011195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801011196	catalytic residue [active]
644801011197	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
644801011198	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
644801011199	tetramerization interface [polypeptide binding]; other site
644801011200	NAD(P) binding site [chemical binding]; other site
644801011201	catalytic residues [active]
644801011202	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
644801011203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801011204	dimer interface [polypeptide binding]; other site
644801011205	conserved gate region; other site
644801011206	putative PBP binding loops; other site
644801011207	ABC-ATPase subunit interface; other site
644801011208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801011209	dimer interface [polypeptide binding]; other site
644801011210	conserved gate region; other site
644801011211	putative PBP binding loops; other site
644801011212	ABC-ATPase subunit interface; other site
644801011213	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
644801011214	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
644801011215	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
644801011216	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
644801011217	Walker A/P-loop; other site
644801011218	ATP binding site [chemical binding]; other site
644801011219	Q-loop/lid; other site
644801011220	ABC transporter signature motif; other site
644801011221	Walker B; other site
644801011222	D-loop; other site
644801011223	H-loop/switch region; other site
644801011224	TOBE domain; Region: TOBE_2; pfam08402
644801011225	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801011226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801011227	active site
644801011228	phosphorylation site [posttranslational modification]
644801011229	intermolecular recognition site; other site
644801011230	dimerization interface [polypeptide binding]; other site
644801011231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801011232	DNA binding residues [nucleotide binding]
644801011233	dimerization interface [polypeptide binding]; other site
644801011234	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801011235	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
644801011236	substrate binding pocket [chemical binding]; other site
644801011237	membrane-bound complex binding site; other site
644801011238	hinge residues; other site
644801011239	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
644801011240	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
644801011241	putative active site [active]
644801011242	heme pocket [chemical binding]; other site
644801011243	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801011244	putative active site [active]
644801011245	heme pocket [chemical binding]; other site
644801011246	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
644801011247	Histidine kinase; Region: HisKA_3; pfam07730
644801011248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801011249	ATP binding site [chemical binding]; other site
644801011250	Mg2+ binding site [ion binding]; other site
644801011251	G-X-G motif; other site
644801011252	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
644801011253	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801011254	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
644801011255	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
644801011256	putative metal binding site [ion binding]; other site
644801011257	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
644801011258	HSP70 interaction site [polypeptide binding]; other site
644801011259	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
644801011260	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
644801011261	Substrate binding site; other site
644801011262	metal-binding site
644801011263	Phosphotransferase enzyme family; Region: APH; pfam01636
644801011264	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
644801011265	active site
644801011266	ATP binding site [chemical binding]; other site
644801011267	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
644801011268	OstA-like protein; Region: OstA; cl00844
644801011269	Organic solvent tolerance protein; Region: OstA_C; pfam04453
644801011270	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
644801011271	SurA N-terminal domain; Region: SurA_N; pfam09312
644801011272	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
644801011273	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
644801011274	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
644801011275	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
644801011276	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
644801011277	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
644801011278	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
644801011279	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
644801011280	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
644801011281	active site
644801011282	metal binding site [ion binding]; metal-binding site
644801011283	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
644801011284	active site residue [active]
644801011285	PrkA family serine protein kinase; Provisional; Region: PRK15455
644801011286	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
644801011287	hypothetical protein; Provisional; Region: PRK05325
644801011288	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
644801011289	SpoVR family protein; Provisional; Region: PRK11767
644801011290	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
644801011291	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
644801011292	active site
644801011293	NTP binding site [chemical binding]; other site
644801011294	metal binding triad [ion binding]; metal-binding site
644801011295	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
644801011296	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
644801011297	catalytic center binding site [active]
644801011298	ATP binding site [chemical binding]; other site
644801011299	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
644801011300	homooctamer interface [polypeptide binding]; other site
644801011301	active site
644801011302	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
644801011303	UGMP family protein; Validated; Region: PRK09604
644801011304	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
644801011305	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
644801011306	DNA primase, catalytic core; Region: dnaG; TIGR01391
644801011307	CHC2 zinc finger; Region: zf-CHC2; pfam01807
644801011308	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
644801011309	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
644801011310	active site
644801011311	metal binding site [ion binding]; metal-binding site
644801011312	interdomain interaction site; other site
644801011313	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
644801011314	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
644801011315	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
644801011316	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
644801011317	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
644801011318	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
644801011319	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801011320	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
644801011321	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801011322	DNA binding residues [nucleotide binding]
644801011323	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
644801011324	transmembrane helices; other site
644801011325	TrkA-C domain; Region: TrkA_C; pfam02080
644801011326	TrkA-C domain; Region: TrkA_C; pfam02080
644801011327	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
644801011328	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
644801011329	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
644801011330	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
644801011331	homodimer interface [polypeptide binding]; other site
644801011332	substrate-cofactor binding pocket; other site
644801011333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801011334	catalytic residue [active]
644801011335	thioredoxin 2; Provisional; Region: PRK10996
644801011336	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
644801011337	catalytic residues [active]
644801011338	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
644801011339	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
644801011340	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
644801011341	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
644801011342	putative acyl-acceptor binding pocket; other site
644801011343	Phosphopantetheine attachment site; Region: PP-binding; cl09936
644801011344	acyl carrier protein; Provisional; Region: PRK05350
644801011345	Predicted membrane protein [Function unknown]; Region: COG4648
644801011346	AMP-binding enzyme; Region: AMP-binding; pfam00501
644801011347	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
644801011348	active site
644801011349	CoA binding site [chemical binding]; other site
644801011350	AMP binding site [chemical binding]; other site
644801011351	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
644801011352	active site 2 [active]
644801011353	dimer interface [polypeptide binding]; other site
644801011354	active site 1 [active]
644801011355	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
644801011356	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
644801011357	Ligand binding site; other site
644801011358	Putative Catalytic site; other site
644801011359	DXD motif; other site
644801011360	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
644801011361	putative acyl-acceptor binding pocket; other site
644801011362	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
644801011363	active sites [active]
644801011364	tetramer interface [polypeptide binding]; other site
644801011365	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
644801011366	active site
644801011367	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
644801011368	Predicted exporter [General function prediction only]; Region: COG4258
644801011369	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
644801011370	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
644801011371	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
644801011372	dimer interface [polypeptide binding]; other site
644801011373	active site
644801011374	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
644801011375	putative active site 1 [active]
644801011376	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801011377	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
644801011378	NAD(P) binding site [chemical binding]; other site
644801011379	active site
644801011380	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
644801011381	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
644801011382	dimer interface [polypeptide binding]; other site
644801011383	active site
644801011384	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
644801011385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801011386	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
644801011387	dimerization interface [polypeptide binding]; other site
644801011388	substrate binding pocket [chemical binding]; other site
644801011389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801011390	putative substrate translocation pore; other site
644801011391	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
644801011392	substrate binding site [chemical binding]; other site
644801011393	active site
644801011394	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
644801011395	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
644801011396	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
644801011397	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
644801011398	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
644801011399	active site
644801011400	dimer interface [polypeptide binding]; other site
644801011401	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
644801011402	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
644801011403	active site
644801011404	FMN binding site [chemical binding]; other site
644801011405	substrate binding site [chemical binding]; other site
644801011406	3Fe-4S cluster binding site [ion binding]; other site
644801011407	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
644801011408	domain interface; other site
644801011409	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
644801011410	Sporulation related domain; Region: SPOR; pfam05036
644801011411	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
644801011412	active site
644801011413	dimer interface [polypeptide binding]; other site
644801011414	metal binding site [ion binding]; metal-binding site
644801011415	shikimate kinase; Reviewed; Region: aroK; PRK00131
644801011416	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
644801011417	ADP binding site [chemical binding]; other site
644801011418	magnesium binding site [ion binding]; other site
644801011419	putative shikimate binding site; other site
644801011420	AMIN domain; Region: AMIN; pfam11741
644801011421	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
644801011422	Secretin and TonB N terminus short domain; Region: STN; smart00965
644801011423	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
644801011424	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
644801011425	Pilus assembly protein, PilP; Region: PilP; pfam04351
644801011426	Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167
644801011427	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
644801011428	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
644801011429	Competence protein A; Region: Competence_A; pfam11104
644801011430	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
644801011431	nucleotide binding site [chemical binding]; other site
644801011432	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
644801011433	Transglycosylase; Region: Transgly; pfam00912
644801011434	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
644801011435	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
644801011436	Malic enzyme, N-terminal domain; Region: malic; pfam00390
644801011437	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
644801011438	putative NAD(P) binding site [chemical binding]; other site
644801011439	Staphylococcal nuclease homologues; Region: SNc; smart00318
644801011440	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
644801011441	Catalytic site; other site
644801011442	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
644801011443	primosome assembly protein PriA; Validated; Region: PRK05580
644801011444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801011445	ATP binding site [chemical binding]; other site
644801011446	putative Mg++ binding site [ion binding]; other site
644801011447	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
644801011448	helicase superfamily c-terminal domain; Region: HELICc; smart00490
644801011449	ATP-binding site [chemical binding]; other site
644801011450	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
644801011451	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
644801011452	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
644801011453	active site
644801011454	HIGH motif; other site
644801011455	KMSK motif region; other site
644801011456	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
644801011457	tRNA binding surface [nucleotide binding]; other site
644801011458	anticodon binding site; other site
644801011459	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
644801011460	Sporulation related domain; Region: SPOR; pfam05036
644801011461	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
644801011462	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
644801011463	catalytic loop [active]
644801011464	iron binding site [ion binding]; other site
644801011465	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
644801011466	FAD binding pocket [chemical binding]; other site
644801011467	FAD binding motif [chemical binding]; other site
644801011468	phosphate binding motif [ion binding]; other site
644801011469	beta-alpha-beta structure motif; other site
644801011470	NAD binding pocket [chemical binding]; other site
644801011471	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
644801011472	transcription termination factor Rho; Provisional; Region: rho; PRK09376
644801011473	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
644801011474	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
644801011475	RNA binding site [nucleotide binding]; other site
644801011476	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
644801011477	multimer interface [polypeptide binding]; other site
644801011478	Walker A motif; other site
644801011479	ATP binding site [chemical binding]; other site
644801011480	Walker B motif; other site
644801011481	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
644801011482	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
644801011483	catalytic residues [active]
644801011484	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
644801011485	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
644801011486	polyphosphate kinase; Provisional; Region: PRK05443
644801011487	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
644801011488	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
644801011489	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
644801011490	putative active site [active]
644801011491	catalytic site [active]
644801011492	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
644801011493	putative domain interface [polypeptide binding]; other site
644801011494	putative active site [active]
644801011495	catalytic site [active]
644801011496	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
644801011497	dimer interface [polypeptide binding]; other site
644801011498	active site
644801011499	aspartate-rich active site metal binding site; other site
644801011500	allosteric magnesium binding site [ion binding]; other site
644801011501	Schiff base residues; other site
644801011502	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
644801011503	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
644801011504	conserved cys residue [active]
644801011505	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
644801011506	CoenzymeA binding site [chemical binding]; other site
644801011507	subunit interaction site [polypeptide binding]; other site
644801011508	PHB binding site; other site
644801011509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
644801011510	LysE type translocator; Region: LysE; cl00565
644801011511	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
644801011512	Mechanosensitive ion channel; Region: MS_channel; pfam00924
644801011513	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
644801011514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801011515	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801011516	ABC transporter; Region: ABC_tran_2; pfam12848
644801011517	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
644801011518	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
644801011519	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
644801011520	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
644801011521	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
644801011522	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
644801011523	HemY protein N-terminus; Region: HemY_N; pfam07219
644801011524	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
644801011525	uroporphyrinogen-III synthase; Validated; Region: PRK05752
644801011526	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
644801011527	active site
644801011528	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
644801011529	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
644801011530	domain interfaces; other site
644801011531	active site
644801011532	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
644801011533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801011534	active site
644801011535	phosphorylation site [posttranslational modification]
644801011536	intermolecular recognition site; other site
644801011537	dimerization interface [polypeptide binding]; other site
644801011538	LytTr DNA-binding domain; Region: LytTR; pfam04397
644801011539	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
644801011540	Histidine kinase; Region: His_kinase; pfam06580
644801011541	argininosuccinate lyase; Provisional; Region: PRK00855
644801011542	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
644801011543	active sites [active]
644801011544	tetramer interface [polypeptide binding]; other site
644801011545	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
644801011546	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801011547	Coenzyme A binding pocket [chemical binding]; other site
644801011548	NnrS protein; Region: NnrS; pfam05940
644801011549	TIGR02647 family protein; Region: DNA
644801011550	adenylate cyclase; Provisional; Region: cyaA; PRK09450
644801011551	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
644801011552	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
644801011553	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801011554	DNA binding residues [nucleotide binding]
644801011555	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
644801011556	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
644801011557	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
644801011558	putative iron binding site [ion binding]; other site
644801011559	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
644801011560	diaminopimelate decarboxylase; Region: lysA; TIGR01048
644801011561	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
644801011562	active site
644801011563	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
644801011564	substrate binding site [chemical binding]; other site
644801011565	catalytic residues [active]
644801011566	dimer interface [polypeptide binding]; other site
644801011567	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
644801011568	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
644801011569	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
644801011570	Protein of unknown function, DUF484; Region: DUF484; pfam04340
644801011571	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
644801011572	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801011573	active site
644801011574	DNA binding site [nucleotide binding]
644801011575	Int/Topo IB signature motif; other site
644801011576	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
644801011577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801011578	motif II; other site
644801011579	Uncharacterized conserved protein [Function unknown]; Region: COG0432
644801011580	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
644801011581	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
644801011582	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
644801011583	Nitrogen regulatory protein P-II; Region: P-II; smart00938
644801011584	Membrane fusogenic activity; Region: BMFP; pfam04380
644801011585	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
644801011586	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
644801011587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801011588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
644801011589	Walker A motif; other site
644801011590	ATP binding site [chemical binding]; other site
644801011591	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
644801011592	BCCT family transporter; Region: BCCT; cl00569
644801011593	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801011594	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801011595	metal binding site [ion binding]; metal-binding site
644801011596	active site
644801011597	I-site; other site
644801011598	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801011599	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
644801011600	Part of AAA domain; Region: AAA_19; pfam13245
644801011601	Family description; Region: UvrD_C_2; pfam13538
644801011602	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
644801011603	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
644801011604	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
644801011605	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
644801011606	Bacterial transcriptional regulator; Region: IclR; pfam01614
644801011607	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
644801011608	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
644801011609	tetrameric interface [polypeptide binding]; other site
644801011610	NAD binding site [chemical binding]; other site
644801011611	catalytic residues [active]
644801011612	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
644801011613	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
644801011614	putative active site [active]
644801011615	metal binding site [ion binding]; metal-binding site
644801011616	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
644801011617	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
644801011618	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
644801011619	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
644801011620	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
644801011621	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
644801011622	active site
644801011623	catalytic site [active]
644801011624	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
644801011625	trehalose synthase; Region: treS_nterm; TIGR02456
644801011626	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
644801011627	active site
644801011628	catalytic site [active]
644801011629	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
644801011630	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801011631	active site
644801011632	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
644801011633	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
644801011634	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
644801011635	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
644801011636	non-specific DNA binding site [nucleotide binding]; other site
644801011637	salt bridge; other site
644801011638	sequence-specific DNA binding site [nucleotide binding]; other site
644801011639	Cupin domain; Region: Cupin_2; pfam07883
644801011640	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
644801011641	homotrimer interaction site [polypeptide binding]; other site
644801011642	putative active site [active]
644801011643	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
644801011644	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
644801011645	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
644801011646	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801011647	putative DNA binding site [nucleotide binding]; other site
644801011648	putative Zn2+ binding site [ion binding]; other site
644801011649	AsnC family; Region: AsnC_trans_reg; pfam01037
644801011650	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
644801011651	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
644801011652	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
644801011653	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
644801011654	putative active site [active]
644801011655	catalytic site [active]
644801011656	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
644801011657	putative active site [active]
644801011658	catalytic site [active]
644801011659	Protein of unknown function (DUF962); Region: DUF962; cl01879
644801011660	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801011661	dimer interface [polypeptide binding]; other site
644801011662	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
644801011663	putative CheW interface [polypeptide binding]; other site
644801011664	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
644801011665	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
644801011666	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801011667	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801011668	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
644801011669	CoenzymeA binding site [chemical binding]; other site
644801011670	subunit interaction site [polypeptide binding]; other site
644801011671	PHB binding site; other site
644801011672	hypothetical protein; Reviewed; Region: PRK00024
644801011673	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
644801011674	MPN+ (JAMM) motif; other site
644801011675	Zinc-binding site [ion binding]; other site
644801011676	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
644801011677	Flavoprotein; Region: Flavoprotein; pfam02441
644801011678	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
644801011679	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
644801011680	trimer interface [polypeptide binding]; other site
644801011681	active site
644801011682	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
644801011683	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
644801011684	active site
644801011685	substrate binding site [chemical binding]; other site
644801011686	metal binding site [ion binding]; metal-binding site
644801011687	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
644801011688	feedback inhibition sensing region; other site
644801011689	homohexameric interface [polypeptide binding]; other site
644801011690	nucleotide binding site [chemical binding]; other site
644801011691	N-acetyl-L-glutamate binding site [chemical binding]; other site
644801011692	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
644801011693	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801011694	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801011695	active site
644801011696	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
644801011697	putative active site [active]
644801011698	putative catalytic site [active]
644801011699	putative DNA binding site [nucleotide binding]; other site
644801011700	putative phosphate binding site [ion binding]; other site
644801011701	metal binding site A [ion binding]; metal-binding site
644801011702	putative AP binding site [nucleotide binding]; other site
644801011703	putative metal binding site B [ion binding]; other site
644801011704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
644801011705	ribonuclease PH; Reviewed; Region: rph; PRK00173
644801011706	Ribonuclease PH; Region: RNase_PH_bact; cd11362
644801011707	hexamer interface [polypeptide binding]; other site
644801011708	active site
644801011709	hypothetical protein; Provisional; Region: PRK11820
644801011710	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
644801011711	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
644801011712	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
644801011713	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
644801011714	catalytic site [active]
644801011715	G-X2-G-X-G-K; other site
644801011716	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
644801011717	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
644801011718	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801011719	Zn2+ binding site [ion binding]; other site
644801011720	Mg2+ binding site [ion binding]; other site
644801011721	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
644801011722	synthetase active site [active]
644801011723	NTP binding site [chemical binding]; other site
644801011724	metal binding site [ion binding]; metal-binding site
644801011725	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
644801011726	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
644801011727	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
644801011728	homotrimer interaction site [polypeptide binding]; other site
644801011729	putative active site [active]
644801011730	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801011731	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
644801011732	ligand binding site [chemical binding]; other site
644801011733	FecR protein; Region: FecR; pfam04773
644801011734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801011735	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
644801011736	Walker A motif; other site
644801011737	ATP binding site [chemical binding]; other site
644801011738	Walker B motif; other site
644801011739	arginine finger; other site
644801011740	Peptidase family M41; Region: Peptidase_M41; pfam01434
644801011741	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
644801011742	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
644801011743	conserved cys residue [active]
644801011744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801011745	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
644801011746	Repair protein; Region: Repair_PSII; cl01535
644801011747	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
644801011748	Repair protein; Region: Repair_PSII; pfam04536
644801011749	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
644801011750	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801011751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801011752	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
644801011753	putative effector binding pocket; other site
644801011754	dimerization interface [polypeptide binding]; other site
644801011755	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
644801011756	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
644801011757	putative NAD(P) binding site [chemical binding]; other site
644801011758	dimer interface [polypeptide binding]; other site
644801011759	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
644801011760	CoA-transferase family III; Region: CoA_transf_3; pfam02515
644801011761	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
644801011762	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801011763	FAD binding site [chemical binding]; other site
644801011764	substrate binding pocket [chemical binding]; other site
644801011765	catalytic base [active]
644801011766	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
644801011767	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801011768	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
644801011769	dimerization interface [polypeptide binding]; other site
644801011770	substrate binding pocket [chemical binding]; other site
644801011771	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
644801011772	IHF dimer interface [polypeptide binding]; other site
644801011773	IHF - DNA interface [nucleotide binding]; other site
644801011774	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
644801011775	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
644801011776	Rubredoxin [Energy production and conversion]; Region: COG1773
644801011777	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
644801011778	iron binding site [ion binding]; other site
644801011779	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
644801011780	L-lactate permease; Region: Lactate_perm; cl00701
644801011781	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
644801011782	active site
644801011783	Domain of unknown function (DUF336); Region: DUF336; cl01249
644801011784	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
644801011785	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
644801011786	Cysteine-rich domain; Region: CCG; pfam02754
644801011787	Cysteine-rich domain; Region: CCG; pfam02754
644801011788	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
644801011789	FAD binding domain; Region: FAD_binding_4; pfam01565
644801011790	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
644801011791	FAD binding domain; Region: FAD_binding_4; pfam01565
644801011792	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
644801011793	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
644801011794	DNA-binding site [nucleotide binding]; DNA binding site
644801011795	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
644801011796	Chorismate lyase; Region: Chor_lyase; cl01230
644801011797	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
644801011798	UbiA prenyltransferase family; Region: UbiA; pfam01040
644801011799	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
644801011800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801011801	active site
644801011802	phosphorylation site [posttranslational modification]
644801011803	intermolecular recognition site; other site
644801011804	dimerization interface [polypeptide binding]; other site
644801011805	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801011806	DNA binding site [nucleotide binding]
644801011807	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
644801011808	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
644801011809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801011810	putative active site [active]
644801011811	heme pocket [chemical binding]; other site
644801011812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801011813	dimer interface [polypeptide binding]; other site
644801011814	phosphorylation site [posttranslational modification]
644801011815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801011816	ATP binding site [chemical binding]; other site
644801011817	Mg2+ binding site [ion binding]; other site
644801011818	G-X-G motif; other site
644801011819	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
644801011820	Domain of unknown function DUF21; Region: DUF21; pfam01595
644801011821	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
644801011822	Transporter associated domain; Region: CorC_HlyC; smart01091
644801011823	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801011824	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
644801011825	Peptidase family M23; Region: Peptidase_M23; pfam01551
644801011826	Response regulator receiver domain; Region: Response_reg; pfam00072
644801011827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801011828	active site
644801011829	phosphorylation site [posttranslational modification]
644801011830	intermolecular recognition site; other site
644801011831	dimerization interface [polypeptide binding]; other site
644801011832	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801011833	Ligand Binding Site [chemical binding]; other site
644801011834	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801011835	Ligand Binding Site [chemical binding]; other site
644801011836	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
644801011837	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
644801011838	putative ligand binding site [chemical binding]; other site
644801011839	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
644801011840	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
644801011841	Walker A/P-loop; other site
644801011842	ATP binding site [chemical binding]; other site
644801011843	Q-loop/lid; other site
644801011844	ABC transporter signature motif; other site
644801011845	Walker B; other site
644801011846	D-loop; other site
644801011847	H-loop/switch region; other site
644801011848	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
644801011849	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
644801011850	Walker A/P-loop; other site
644801011851	ATP binding site [chemical binding]; other site
644801011852	Q-loop/lid; other site
644801011853	ABC transporter signature motif; other site
644801011854	Walker B; other site
644801011855	D-loop; other site
644801011856	H-loop/switch region; other site
644801011857	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
644801011858	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
644801011859	TM-ABC transporter signature motif; other site
644801011860	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
644801011861	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
644801011862	TM-ABC transporter signature motif; other site
644801011863	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
644801011864	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801011865	P-loop; other site
644801011866	Magnesium ion binding site [ion binding]; other site
644801011867	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801011868	Magnesium ion binding site [ion binding]; other site
644801011869	thymidylate synthase; Reviewed; Region: thyA; PRK01827
644801011870	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
644801011871	dimerization interface [polypeptide binding]; other site
644801011872	active site
644801011873	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
644801011874	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
644801011875	NRDE protein; Region: NRDE; cl01315
644801011876	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
644801011877	GAF domain; Region: GAF; pfam01590
644801011878	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
644801011879	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
644801011880	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
644801011881	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
644801011882	putative active site [active]
644801011883	Ap4A binding site [chemical binding]; other site
644801011884	nudix motif; other site
644801011885	putative metal binding site [ion binding]; other site
644801011886	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
644801011887	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
644801011888	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
644801011889	threonine dehydratase; Reviewed; Region: PRK09224
644801011890	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
644801011891	tetramer interface [polypeptide binding]; other site
644801011892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801011893	catalytic residue [active]
644801011894	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
644801011895	putative Ile/Val binding site [chemical binding]; other site
644801011896	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
644801011897	putative Ile/Val binding site [chemical binding]; other site
644801011898	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
644801011899	tetramer (dimer of dimers) interface [polypeptide binding]; other site
644801011900	active site
644801011901	dimer interface [polypeptide binding]; other site
644801011902	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
644801011903	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
644801011904	SdiA-regulated; Region: SdiA-regulated; pfam06977
644801011905	SdiA-regulated; Region: SdiA-regulated; cd09971
644801011906	putative active site [active]
644801011907	SdiA-regulated; Region: SdiA-regulated; pfam06977
644801011908	SdiA-regulated; Region: SdiA-regulated; cd09971
644801011909	putative active site [active]
644801011910	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
644801011911	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
644801011912	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
644801011913	FAD binding domain; Region: FAD_binding_4; pfam01565
644801011914	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
644801011915	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
644801011916	ligand binding site [chemical binding]; other site
644801011917	NAD binding site [chemical binding]; other site
644801011918	tetramer interface [polypeptide binding]; other site
644801011919	catalytic site [active]
644801011920	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
644801011921	L-serine binding site [chemical binding]; other site
644801011922	ACT domain interface; other site
644801011923	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
644801011924	OPT oligopeptide transporter protein; Region: OPT; cl14607
644801011925	OPT oligopeptide transporter protein; Region: OPT; cl14607
644801011926	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
644801011927	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
644801011928	DNA binding residues [nucleotide binding]
644801011929	dimerization interface [polypeptide binding]; other site
644801011930	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801011931	Curlin associated repeat; Region: Curlin_rpt; pfam07012
644801011932	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801011933	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
644801011934	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
644801011935	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
644801011936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801011937	active site
644801011938	phosphorylation site [posttranslational modification]
644801011939	intermolecular recognition site; other site
644801011940	dimerization interface [polypeptide binding]; other site
644801011941	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801011942	DNA binding site [nucleotide binding]
644801011943	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
644801011944	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
644801011945	dimer interface [polypeptide binding]; other site
644801011946	phosphorylation site [posttranslational modification]
644801011947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801011948	ATP binding site [chemical binding]; other site
644801011949	Mg2+ binding site [ion binding]; other site
644801011950	G-X-G motif; other site
644801011951	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
644801011952	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801011953	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
644801011954	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801011955	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801011956	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
644801011957	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
644801011958	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
644801011959	Carbon starvation protein CstA; Region: CstA; pfam02554
644801011960	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
644801011961	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
644801011962	DTAP/Switch II; other site
644801011963	Switch I; other site
644801011964	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
644801011965	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
644801011966	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
644801011967	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
644801011968	active site
644801011969	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
644801011970	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
644801011971	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801011972	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801011973	metal binding site [ion binding]; metal-binding site
644801011974	active site
644801011975	I-site; other site
644801011976	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801011977	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
644801011978	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
644801011979	FAD binding pocket [chemical binding]; other site
644801011980	conserved FAD binding motif [chemical binding]; other site
644801011981	phosphate binding motif [ion binding]; other site
644801011982	beta-alpha-beta structure motif; other site
644801011983	NAD binding pocket [chemical binding]; other site
644801011984	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
644801011985	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
644801011986	[4Fe-4S] binding site [ion binding]; other site
644801011987	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
644801011988	molybdopterin cofactor binding site; other site
644801011989	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
644801011990	molybdopterin cofactor binding site; other site
644801011991	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
644801011992	Cytochrome c553 [Energy production and conversion]; Region: COG2863
644801011993	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
644801011994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
644801011995	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
644801011996	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
644801011997	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801011998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801011999	active site
644801012000	phosphorylation site [posttranslational modification]
644801012001	intermolecular recognition site; other site
644801012002	dimerization interface [polypeptide binding]; other site
644801012003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801012004	Walker A motif; other site
644801012005	ATP binding site [chemical binding]; other site
644801012006	Walker B motif; other site
644801012007	arginine finger; other site
644801012008	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801012009	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801012010	dimerization interface [polypeptide binding]; other site
644801012011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012012	phosphorylation site [posttranslational modification]
644801012013	dimer interface [polypeptide binding]; other site
644801012014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012015	ATP binding site [chemical binding]; other site
644801012016	Mg2+ binding site [ion binding]; other site
644801012017	G-X-G motif; other site
644801012018	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
644801012019	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801012020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801012021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801012022	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
644801012023	substrate binding pocket [chemical binding]; other site
644801012024	dimerization interface [polypeptide binding]; other site
644801012025	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
644801012026	hydrophobic ligand binding site; other site
644801012027	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
644801012028	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
644801012029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012030	active site
644801012031	phosphorylation site [posttranslational modification]
644801012032	intermolecular recognition site; other site
644801012033	dimerization interface [polypeptide binding]; other site
644801012034	sensory histidine kinase DcuS; Provisional; Region: PRK11086
644801012035	PAS domain; Region: PAS; smart00091
644801012036	putative active site [active]
644801012037	heme pocket [chemical binding]; other site
644801012038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012039	ATP binding site [chemical binding]; other site
644801012040	Mg2+ binding site [ion binding]; other site
644801012041	G-X-G motif; other site
644801012042	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
644801012043	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
644801012044	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
644801012045	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801012046	dimer interface [polypeptide binding]; other site
644801012047	putative CheW interface [polypeptide binding]; other site
644801012048	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
644801012049	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
644801012050	G1 box; other site
644801012051	putative GEF interaction site [polypeptide binding]; other site
644801012052	GTP/Mg2+ binding site [chemical binding]; other site
644801012053	Switch I region; other site
644801012054	G2 box; other site
644801012055	G3 box; other site
644801012056	Switch II region; other site
644801012057	G4 box; other site
644801012058	G5 box; other site
644801012059	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
644801012060	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
644801012061	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
644801012062	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
644801012063	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
644801012064	Ligand Binding Site [chemical binding]; other site
644801012065	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
644801012066	glutamine synthetase; Provisional; Region: glnA; PRK09469
644801012067	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
644801012068	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
644801012069	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801012070	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
644801012071	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
644801012072	PAS domain; Region: PAS; smart00091
644801012073	putative active site [active]
644801012074	heme pocket [chemical binding]; other site
644801012075	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012076	dimer interface [polypeptide binding]; other site
644801012077	phosphorylation site [posttranslational modification]
644801012078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012079	ATP binding site [chemical binding]; other site
644801012080	Mg2+ binding site [ion binding]; other site
644801012081	G-X-G motif; other site
644801012082	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
644801012083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012084	active site
644801012085	phosphorylation site [posttranslational modification]
644801012086	intermolecular recognition site; other site
644801012087	dimerization interface [polypeptide binding]; other site
644801012088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801012089	Walker A motif; other site
644801012090	ATP binding site [chemical binding]; other site
644801012091	Walker B motif; other site
644801012092	arginine finger; other site
644801012093	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801012094	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
644801012095	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
644801012096	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
644801012097	putative molybdopterin cofactor binding site [chemical binding]; other site
644801012098	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
644801012099	putative molybdopterin cofactor binding site; other site
644801012100	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
644801012101	active site
644801012102	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
644801012103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801012104	Walker A motif; other site
644801012105	ATP binding site [chemical binding]; other site
644801012106	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
644801012107	Walker B motif; other site
644801012108	arginine finger; other site
644801012109	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
644801012110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
644801012111	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
644801012112	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
644801012113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801012114	S-adenosylmethionine binding site [chemical binding]; other site
644801012115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
644801012116	SCP-2 sterol transfer family; Region: SCP2; pfam02036
644801012117	ABC1 family; Region: ABC1; cl17513
644801012118	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
644801012119	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
644801012120	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
644801012121	metal binding site [ion binding]; metal-binding site
644801012122	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
644801012123	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
644801012124	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
644801012125	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
644801012126	RNA methyltransferase, RsmE family; Region: TIGR00046
644801012127	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
644801012128	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
644801012129	putative active site [active]
644801012130	dimerization interface [polypeptide binding]; other site
644801012131	putative tRNAtyr binding site [nucleotide binding]; other site
644801012132	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
644801012133	TAP-like protein; Region: Abhydrolase_4; pfam08386
644801012134	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
644801012135	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
644801012136	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
644801012137	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
644801012138	fructose-1,6-bisphosphatase family protein; Region: PLN02628
644801012139	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
644801012140	AMP binding site [chemical binding]; other site
644801012141	metal binding site [ion binding]; metal-binding site
644801012142	active site
644801012143	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
644801012144	homodimer interface [polypeptide binding]; other site
644801012145	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
644801012146	active site pocket [active]
644801012147	Flagellin N-methylase; Region: FliB; pfam03692
644801012148	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
644801012149	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
644801012150	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
644801012151	active site
644801012152	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
644801012153	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
644801012154	dimer interface [polypeptide binding]; other site
644801012155	ADP-ribose binding site [chemical binding]; other site
644801012156	active site
644801012157	nudix motif; other site
644801012158	metal binding site [ion binding]; metal-binding site
644801012159	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
644801012160	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
644801012161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801012162	motif II; other site
644801012163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012164	heme pocket [chemical binding]; other site
644801012165	putative active site [active]
644801012166	PAS fold; Region: PAS_4; pfam08448
644801012167	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012168	putative active site [active]
644801012169	heme pocket [chemical binding]; other site
644801012170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012171	dimer interface [polypeptide binding]; other site
644801012172	phosphorylation site [posttranslational modification]
644801012173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012174	ATP binding site [chemical binding]; other site
644801012175	Mg2+ binding site [ion binding]; other site
644801012176	G-X-G motif; other site
644801012177	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801012178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012179	active site
644801012180	phosphorylation site [posttranslational modification]
644801012181	intermolecular recognition site; other site
644801012182	dimerization interface [polypeptide binding]; other site
644801012183	Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526
644801012184	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
644801012185	active site
644801012186	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
644801012187	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
644801012188	putative active site [active]
644801012189	metal binding site [ion binding]; metal-binding site
644801012190	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
644801012191	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
644801012192	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801012193	active site
644801012194	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
644801012195	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
644801012196	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
644801012197	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801012198	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801012199	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801012200	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801012201	The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468
644801012202	putative substrate binding pocket [chemical binding]; other site
644801012203	dimerization interface [polypeptide binding]; other site
644801012204	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
644801012205	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
644801012206	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
644801012207	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
644801012208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
644801012209	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
644801012210	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
644801012211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012212	dimer interface [polypeptide binding]; other site
644801012213	phosphorylation site [posttranslational modification]
644801012214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012215	ATP binding site [chemical binding]; other site
644801012216	Mg2+ binding site [ion binding]; other site
644801012217	G-X-G motif; other site
644801012218	Response regulator receiver domain; Region: Response_reg; pfam00072
644801012219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012220	active site
644801012221	phosphorylation site [posttranslational modification]
644801012222	intermolecular recognition site; other site
644801012223	dimerization interface [polypeptide binding]; other site
644801012224	PAS fold; Region: PAS_4; pfam08448
644801012225	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012226	ATP binding site [chemical binding]; other site
644801012227	Mg2+ binding site [ion binding]; other site
644801012228	G-X-G motif; other site
644801012229	Response regulator receiver domain; Region: Response_reg; pfam00072
644801012230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012231	active site
644801012232	phosphorylation site [posttranslational modification]
644801012233	intermolecular recognition site; other site
644801012234	dimerization interface [polypeptide binding]; other site
644801012235	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
644801012236	DNA-binding site [nucleotide binding]; DNA binding site
644801012237	RNA-binding motif; other site
644801012238	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
644801012239	active site
644801012240	catalytic residues [active]
644801012241	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
644801012242	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
644801012243	30S subunit binding site; other site
644801012244	TLC ATP/ADP transporter; Region: TLC; cl03940
644801012245	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
644801012246	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
644801012247	active site
644801012248	catalytic tetrad [active]
644801012249	FIST N domain; Region: FIST; smart00897
644801012250	FIST C domain; Region: FIST_C; pfam10442
644801012251	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
644801012252	dimer interface [polypeptide binding]; other site
644801012253	putative CheW interface [polypeptide binding]; other site
644801012254	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
644801012255	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801012256	ATP binding site [chemical binding]; other site
644801012257	putative Mg++ binding site [ion binding]; other site
644801012258	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801012259	nucleotide binding region [chemical binding]; other site
644801012260	ATP-binding site [chemical binding]; other site
644801012261	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
644801012262	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
644801012263	dimer interface [polypeptide binding]; other site
644801012264	FMN binding site [chemical binding]; other site
644801012265	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
644801012266	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
644801012267	active site
644801012268	substrate-binding site [chemical binding]; other site
644801012269	metal-binding site [ion binding]
644801012270	ATP binding site [chemical binding]; other site
644801012271	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
644801012272	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
644801012273	dimerization interface [polypeptide binding]; other site
644801012274	domain crossover interface; other site
644801012275	redox-dependent activation switch; other site
644801012276	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
644801012277	active site
644801012278	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
644801012279	RNA binding surface [nucleotide binding]; other site
644801012280	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
644801012281	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
644801012282	RimK-like ATP-grasp domain; Region: RimK; pfam08443
644801012283	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
644801012284	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
644801012285	dimerization interface [polypeptide binding]; other site
644801012286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012287	ATP binding site [chemical binding]; other site
644801012288	Mg2+ binding site [ion binding]; other site
644801012289	G-X-G motif; other site
644801012290	osmolarity response regulator; Provisional; Region: ompR; PRK09468
644801012291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012292	active site
644801012293	phosphorylation site [posttranslational modification]
644801012294	intermolecular recognition site; other site
644801012295	dimerization interface [polypeptide binding]; other site
644801012296	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
644801012297	DNA binding site [nucleotide binding]
644801012298	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
644801012299	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
644801012300	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
644801012301	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
644801012302	RNA binding site [nucleotide binding]; other site
644801012303	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
644801012304	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
644801012305	CoenzymeA binding site [chemical binding]; other site
644801012306	subunit interaction site [polypeptide binding]; other site
644801012307	PHB binding site; other site
644801012308	glutamate--cysteine ligase; Provisional; Region: PRK02107
644801012309	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
644801012310	N-acetylglutamate synthase; Validated; Region: PRK05279
644801012311	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
644801012312	putative feedback inhibition sensing region; other site
644801012313	putative nucleotide binding site [chemical binding]; other site
644801012314	putative substrate binding site [chemical binding]; other site
644801012315	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801012316	Coenzyme A binding pocket [chemical binding]; other site
644801012317	acetylornithine deacetylase; Provisional; Region: PRK05111
644801012318	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
644801012319	metal binding site [ion binding]; metal-binding site
644801012320	putative dimer interface [polypeptide binding]; other site
644801012321	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
644801012322	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
644801012323	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
644801012324	Uncharacterized conserved protein [Function unknown]; Region: COG3025
644801012325	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
644801012326	putative active site [active]
644801012327	putative metal binding residues [ion binding]; other site
644801012328	signature motif; other site
644801012329	putative triphosphate binding site [ion binding]; other site
644801012330	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
644801012331	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
644801012332	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
644801012333	Walker A motif; other site
644801012334	ATP binding site [chemical binding]; other site
644801012335	Walker B motif; other site
644801012336	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
644801012337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
644801012338	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
644801012339	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
644801012340	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
644801012341	PAS domain S-box; Region: sensory_box; TIGR00229
644801012342	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012343	putative active site [active]
644801012344	heme pocket [chemical binding]; other site
644801012345	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012346	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
644801012347	putative active site [active]
644801012348	heme pocket [chemical binding]; other site
644801012349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012350	putative active site [active]
644801012351	heme pocket [chemical binding]; other site
644801012352	PAS fold; Region: PAS_3; pfam08447
644801012353	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
644801012354	GAF domain; Region: GAF; pfam01590
644801012355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012356	PAS domain; Region: PAS_9; pfam13426
644801012357	putative active site [active]
644801012358	heme pocket [chemical binding]; other site
644801012359	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012360	dimer interface [polypeptide binding]; other site
644801012361	phosphorylation site [posttranslational modification]
644801012362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012363	ATP binding site [chemical binding]; other site
644801012364	Mg2+ binding site [ion binding]; other site
644801012365	G-X-G motif; other site
644801012366	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801012367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012368	active site
644801012369	phosphorylation site [posttranslational modification]
644801012370	intermolecular recognition site; other site
644801012371	dimerization interface [polypeptide binding]; other site
644801012372	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
644801012373	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
644801012374	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
644801012375	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801012376	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
644801012377	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
644801012378	DctM-like transporters; Region: DctM; pfam06808
644801012379	Methyltransferase domain; Region: Methyltransf_32; pfam13679
644801012380	integrase; Provisional; Region: PRK09692
644801012381	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
644801012382	active site
644801012383	Int/Topo IB signature motif; other site
644801012384	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
644801012385	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
644801012386	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
644801012387	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
644801012388	Chromate transporter; Region: Chromate_transp; pfam02417
644801012389	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
644801012390	active site residue [active]
644801012391	conjugal transfer protein TrbP; Provisional; Region: PRK13882
644801012392	TraX protein; Region: TraX; pfam05857
644801012393	Predicted membrane protein [Function unknown]; Region: COG1238
644801012394	High-affinity nickel-transport protein; Region: NicO; cl00964
644801012395	High-affinity nickel-transport protein; Region: NicO; cl00964
644801012396	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
644801012397	putative homodimer interface [polypeptide binding]; other site
644801012398	putative homotetramer interface [polypeptide binding]; other site
644801012399	putative metal binding site [ion binding]; other site
644801012400	putative homodimer-homodimer interface [polypeptide binding]; other site
644801012401	putative allosteric switch controlling residues; other site
644801012402	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
644801012403	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
644801012404	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
644801012405	motif II; other site
644801012406	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
644801012407	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
644801012408	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
644801012409	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
644801012410	catalytic residues [active]
644801012411	catalytic nucleophile [active]
644801012412	Presynaptic Site I dimer interface [polypeptide binding]; other site
644801012413	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
644801012414	Synaptic Flat tetramer interface [polypeptide binding]; other site
644801012415	Synaptic Site I dimer interface [polypeptide binding]; other site
644801012416	DNA binding site [nucleotide binding]
644801012417	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
644801012418	DNA-binding interface [nucleotide binding]; DNA binding site
644801012419	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
644801012420	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
644801012421	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801012422	ATP binding site [chemical binding]; other site
644801012423	putative Mg++ binding site [ion binding]; other site
644801012424	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
644801012425	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
644801012426	Divergent AAA domain; Region: AAA_4; pfam04326
644801012427	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
644801012428	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
644801012429	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
644801012430	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
644801012431	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
644801012432	HsdM N-terminal domain; Region: HsdM_N; pfam12161
644801012433	HsdM N-terminal domain; Region: HsdM_N; pfam12161
644801012434	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
644801012435	Methyltransferase domain; Region: Methyltransf_26; pfam13659
644801012436	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
644801012437	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
644801012438	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
644801012439	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
644801012440	Walker A/P-loop; other site
644801012441	ATP binding site [chemical binding]; other site
644801012442	Q-loop/lid; other site
644801012443	ABC transporter signature motif; other site
644801012444	Walker B; other site
644801012445	D-loop; other site
644801012446	H-loop/switch region; other site
644801012447	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
644801012448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801012449	dimer interface [polypeptide binding]; other site
644801012450	conserved gate region; other site
644801012451	putative PBP binding loops; other site
644801012452	ABC-ATPase subunit interface; other site
644801012453	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
644801012454	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
644801012455	active site
644801012456	dimer interface [polypeptide binding]; other site
644801012457	non-prolyl cis peptide bond; other site
644801012458	insertion regions; other site
644801012459	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
644801012460	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801012461	substrate binding pocket [chemical binding]; other site
644801012462	membrane-bound complex binding site; other site
644801012463	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
644801012464	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
644801012465	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
644801012466	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
644801012467	dimer interface [polypeptide binding]; other site
644801012468	decamer (pentamer of dimers) interface [polypeptide binding]; other site
644801012469	catalytic triad [active]
644801012470	Serine hydrolase; Region: Ser_hydrolase; pfam06821
644801012471	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
644801012472	Uncharacterized small protein [Function unknown]; Region: COG5583
644801012473	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
644801012474	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
644801012475	substrate binding pocket [chemical binding]; other site
644801012476	membrane-bound complex binding site; other site
644801012477	hinge residues; other site
644801012478	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
644801012479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801012480	dimer interface [polypeptide binding]; other site
644801012481	conserved gate region; other site
644801012482	putative PBP binding loops; other site
644801012483	ABC-ATPase subunit interface; other site
644801012484	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
644801012485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801012486	dimer interface [polypeptide binding]; other site
644801012487	conserved gate region; other site
644801012488	putative PBP binding loops; other site
644801012489	ABC-ATPase subunit interface; other site
644801012490	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
644801012491	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
644801012492	Walker A/P-loop; other site
644801012493	ATP binding site [chemical binding]; other site
644801012494	Q-loop/lid; other site
644801012495	ABC transporter signature motif; other site
644801012496	Walker B; other site
644801012497	D-loop; other site
644801012498	H-loop/switch region; other site
644801012499	TOBE-like domain; Region: TOBE_3; pfam12857
644801012500	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
644801012501	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
644801012502	putative ligand binding site [chemical binding]; other site
644801012503	putative NAD binding site [chemical binding]; other site
644801012504	catalytic site [active]
644801012505	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
644801012506	active site
644801012507	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
644801012508	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
644801012509	Predicted membrane protein [Function unknown]; Region: COG2261
644801012510	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
644801012511	ATP-grasp domain; Region: ATP-grasp; pfam02222
644801012512	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
644801012513	Cache domain; Region: Cache_1; pfam02743
644801012514	PAS domain S-box; Region: sensory_box; TIGR00229
644801012515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012516	putative active site [active]
644801012517	heme pocket [chemical binding]; other site
644801012518	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
644801012519	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012520	dimer interface [polypeptide binding]; other site
644801012521	phosphorylation site [posttranslational modification]
644801012522	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012523	ATP binding site [chemical binding]; other site
644801012524	Mg2+ binding site [ion binding]; other site
644801012525	G-X-G motif; other site
644801012526	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
644801012527	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
644801012528	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
644801012529	dimer interface [polypeptide binding]; other site
644801012530	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
644801012531	active site
644801012532	Fe binding site [ion binding]; other site
644801012533	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
644801012534	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
644801012535	acyl-activating enzyme (AAE) consensus motif; other site
644801012536	AMP binding site [chemical binding]; other site
644801012537	active site
644801012538	CoA binding site [chemical binding]; other site
644801012539	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
644801012540	cell density-dependent motility repressor; Provisional; Region: PRK10082
644801012541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801012542	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
644801012543	dimerization interface [polypeptide binding]; other site
644801012544	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
644801012545	Aspartase; Region: Aspartase; cd01357
644801012546	active sites [active]
644801012547	tetramer interface [polypeptide binding]; other site
644801012548	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
644801012549	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
644801012550	Helix-turn-helix domain; Region: HTH_19; pfam12844
644801012551	non-specific DNA binding site [nucleotide binding]; other site
644801012552	salt bridge; other site
644801012553	sequence-specific DNA binding site [nucleotide binding]; other site
644801012554	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
644801012555	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
644801012556	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
644801012557	active site
644801012558	homodimer interface [polypeptide binding]; other site
644801012559	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
644801012560	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
644801012561	substrate binding pocket [chemical binding]; other site
644801012562	membrane-bound complex binding site; other site
644801012563	hinge residues; other site
644801012564	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
644801012565	active site clefts [active]
644801012566	zinc binding site [ion binding]; other site
644801012567	dimer interface [polypeptide binding]; other site
644801012568	glutaminase; Provisional; Region: PRK00971
644801012569	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
644801012570	Domain of unknown function (DUF897); Region: DUF897; cl01312
644801012571	pyruvate carboxylase subunit B; Validated; Region: PRK09282
644801012572	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
644801012573	active site
644801012574	catalytic residues [active]
644801012575	metal binding site [ion binding]; metal-binding site
644801012576	homodimer binding site [polypeptide binding]; other site
644801012577	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
644801012578	carboxyltransferase (CT) interaction site; other site
644801012579	biotinylation site [posttranslational modification]; other site
644801012580	pyruvate carboxylase subunit A; Validated; Region: PRK07178
644801012581	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
644801012582	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
644801012583	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
644801012584	Transcriptional regulator [Transcription]; Region: LysR; COG0583
644801012585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801012586	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
644801012587	putative dimerization interface [polypeptide binding]; other site
644801012588	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
644801012589	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
644801012590	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
644801012591	putative active site [active]
644801012592	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
644801012593	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
644801012594	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
644801012595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
644801012596	Coenzyme A binding pocket [chemical binding]; other site
644801012597	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
644801012598	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801012599	inhibitor-cofactor binding pocket; inhibition site
644801012600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801012601	catalytic residue [active]
644801012602	Ectoine synthase; Region: Ectoine_synth; pfam06339
644801012603	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
644801012604	aspartate kinase; Validated; Region: PRK09181
644801012605	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
644801012606	nucleotide binding site [chemical binding]; other site
644801012607	substrate binding site [chemical binding]; other site
644801012608	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910
644801012609	allosteric regulatory residue; other site
644801012610	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
644801012611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
644801012612	putative protease; Provisional; Region: PRK15452
644801012613	Peptidase family U32; Region: Peptidase_U32; pfam01136
644801012614	PAS fold; Region: PAS_3; pfam08447
644801012615	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
644801012616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012617	PAS domain; Region: PAS_9; pfam13426
644801012618	putative active site [active]
644801012619	heme pocket [chemical binding]; other site
644801012620	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801012621	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801012622	metal binding site [ion binding]; metal-binding site
644801012623	active site
644801012624	I-site; other site
644801012625	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
644801012626	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
644801012627	Part of AAA domain; Region: AAA_19; pfam13245
644801012628	Family description; Region: UvrD_C_2; pfam13538
644801012629	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801012630	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
644801012631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
644801012632	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
644801012633	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
644801012634	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
644801012635	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
644801012636	Cupin; Region: Cupin_6; pfam12852
644801012637	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801012638	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
644801012639	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801012640	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
644801012641	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
644801012642	[4Fe-4S] binding site [ion binding]; other site
644801012643	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801012644	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
644801012645	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
644801012646	molybdopterin cofactor binding site; other site
644801012647	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
644801012648	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
644801012649	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
644801012650	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
644801012651	Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058
644801012652	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
644801012653	selenocysteine synthase; Provisional; Region: PRK04311
644801012654	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
644801012655	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
644801012656	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
644801012657	catalytic residue [active]
644801012658	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
644801012659	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
644801012660	G1 box; other site
644801012661	putative GEF interaction site [polypeptide binding]; other site
644801012662	GTP/Mg2+ binding site [chemical binding]; other site
644801012663	Switch I region; other site
644801012664	G2 box; other site
644801012665	G3 box; other site
644801012666	Switch II region; other site
644801012667	G4 box; other site
644801012668	G5 box; other site
644801012669	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
644801012670	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
644801012671	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
644801012672	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
644801012673	hypothetical protein; Provisional; Region: PRK01184
644801012674	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
644801012675	active site
644801012676	Zn binding site [ion binding]; other site
644801012677	Protein of unknown function (DUF2523); Region: DUF2523; pfam10734
644801012678	Zonular occludens toxin (Zot); Region: Zot; cl17485
644801012679	integrase; Provisional; Region: int; PHA02601
644801012680	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
644801012681	active site
644801012682	DNA binding site [nucleotide binding]
644801012683	Int/Topo IB signature motif; other site
644801012684	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
644801012685	lipoyl attachment site [posttranslational modification]; other site
644801012686	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
644801012687	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
644801012688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801012689	S-adenosylmethionine binding site [chemical binding]; other site
644801012690	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801012691	Ligand Binding Site [chemical binding]; other site
644801012692	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
644801012693	Ligand Binding Site [chemical binding]; other site
644801012694	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
644801012695	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
644801012696	Sulfate transporter family; Region: Sulfate_transp; pfam00916
644801012697	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
644801012698	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
644801012699	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
644801012700	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
644801012701	Zn2+ binding site [ion binding]; other site
644801012702	Mg2+ binding site [ion binding]; other site
644801012703	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
644801012704	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012705	dimer interface [polypeptide binding]; other site
644801012706	phosphorylation site [posttranslational modification]
644801012707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012708	ATP binding site [chemical binding]; other site
644801012709	Mg2+ binding site [ion binding]; other site
644801012710	G-X-G motif; other site
644801012711	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801012712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012713	active site
644801012714	phosphorylation site [posttranslational modification]
644801012715	intermolecular recognition site; other site
644801012716	dimerization interface [polypeptide binding]; other site
644801012717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801012718	Walker A motif; other site
644801012719	ATP binding site [chemical binding]; other site
644801012720	Walker B motif; other site
644801012721	arginine finger; other site
644801012722	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801012723	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
644801012724	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801012725	DNA binding residues [nucleotide binding]
644801012726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
644801012727	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
644801012728	SnoaL-like domain; Region: SnoaL_3; pfam13474
644801012729	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
644801012730	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801012731	N-terminal plug; other site
644801012732	ligand-binding site [chemical binding]; other site
644801012733	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
644801012734	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
644801012735	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
644801012736	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
644801012737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012738	putative active site [active]
644801012739	heme pocket [chemical binding]; other site
644801012740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801012741	putative active site [active]
644801012742	heme pocket [chemical binding]; other site
644801012743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801012744	dimer interface [polypeptide binding]; other site
644801012745	phosphorylation site [posttranslational modification]
644801012746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801012747	ATP binding site [chemical binding]; other site
644801012748	Mg2+ binding site [ion binding]; other site
644801012749	G-X-G motif; other site
644801012750	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801012751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012752	active site
644801012753	phosphorylation site [posttranslational modification]
644801012754	intermolecular recognition site; other site
644801012755	dimerization interface [polypeptide binding]; other site
644801012756	Response regulator receiver domain; Region: Response_reg; pfam00072
644801012757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012758	active site
644801012759	phosphorylation site [posttranslational modification]
644801012760	intermolecular recognition site; other site
644801012761	dimerization interface [polypeptide binding]; other site
644801012762	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
644801012763	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
644801012764	active site
644801012765	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
644801012766	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
644801012767	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
644801012768	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
644801012769	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801012770	Rod binding protein; Region: Rod-binding; cl01626
644801012771	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
644801012772	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
644801012773	N-acetyl-D-glucosamine binding site [chemical binding]; other site
644801012774	catalytic residue [active]
644801012775	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
644801012776	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
644801012777	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407
644801012778	Flagellar L-ring protein; Region: FlgH; pfam02107
644801012779	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
644801012780	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801012781	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
644801012782	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
644801012783	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
644801012784	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
644801012785	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
644801012786	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
644801012787	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801012788	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
644801012789	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619
644801012790	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
644801012791	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
644801012792	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
644801012793	Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673
644801012794	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
644801012795	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
644801012796	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
644801012797	SAF-like; Region: SAF_2; pfam13144
644801012798	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
644801012799	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
644801012800	flagellin; Provisional; Region: PRK12802
644801012801	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
644801012802	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
644801012803	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
644801012804	DNA binding site [nucleotide binding]
644801012805	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
644801012806	hypothetical protein; Validated; Region: PRK06778
644801012807	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
644801012808	ligand binding site [chemical binding]; other site
644801012809	flagellar motor protein MotA; Provisional; Region: PRK12482
644801012810	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
644801012811	flagellar biosynthesis sigma factor; Provisional; Region: PRK12427
644801012812	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801012813	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
644801012814	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801012815	DNA binding residues [nucleotide binding]
644801012816	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
644801012817	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
644801012818	Flagellar protein FliS; Region: FliS; cl00654
644801012819	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
644801012820	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
644801012821	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
644801012822	FlgN protein; Region: FlgN; pfam05130
644801012823	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
644801012824	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
644801012825	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
644801012826	Walker A motif/ATP binding site; other site
644801012827	Walker B motif; other site
644801012828	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
644801012829	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
644801012830	Flagellar assembly protein FliH; Region: FliH; pfam02108
644801012831	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
644801012832	MgtE intracellular N domain; Region: MgtE_N; smart00924
644801012833	FliG C-terminal domain; Region: FliG_C; pfam01706
644801012834	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
644801012835	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
644801012836	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
644801012837	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
644801012838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801012839	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801012840	active site
644801012841	phosphorylation site [posttranslational modification]
644801012842	intermolecular recognition site; other site
644801012843	dimerization interface [polypeptide binding]; other site
644801012844	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801012845	Walker A motif; other site
644801012846	ATP binding site [chemical binding]; other site
644801012847	Walker B motif; other site
644801012848	arginine finger; other site
644801012849	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801012850	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
644801012851	flagellar motor switch protein FliN; Region: fliN; TIGR02480
644801012852	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
644801012853	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
644801012854	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
644801012855	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
644801012856	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
644801012857	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
644801012858	FHIPEP family; Region: FHIPEP; pfam00771
644801012859	PilZ domain; Region: PilZ; pfam07238
644801012860	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
644801012861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
644801012862	S-adenosylmethionine binding site [chemical binding]; other site
644801012863	Predicted permeases [General function prediction only]; Region: COG0679
644801012864	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
644801012865	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
644801012866	NAD binding site [chemical binding]; other site
644801012867	catalytic Zn binding site [ion binding]; other site
644801012868	structural Zn binding site [ion binding]; other site
644801012869	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
644801012870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
644801012871	NAD(P) binding site [chemical binding]; other site
644801012872	active site
644801012873	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
644801012874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
644801012875	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
644801012876	dimerization interface [polypeptide binding]; other site
644801012877	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
644801012878	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
644801012879	generic binding surface II; other site
644801012880	ssDNA binding site; other site
644801012881	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
644801012882	ATP binding site [chemical binding]; other site
644801012883	putative Mg++ binding site [ion binding]; other site
644801012884	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
644801012885	nucleotide binding region [chemical binding]; other site
644801012886	ATP-binding site [chemical binding]; other site
644801012887	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
644801012888	putative deacylase active site [active]
644801012889	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
644801012890	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
644801012891	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
644801012892	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
644801012893	GspL periplasmic domain; Region: GspL_C; pfam12693
644801012894	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
644801012895	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
644801012896	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
644801012897	type II secretion system protein I; Region: gspI; TIGR01707
644801012898	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
644801012899	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
644801012900	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
644801012901	type II secretion system protein F; Region: GspF; TIGR02120
644801012902	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
644801012903	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
644801012904	type II secretion system protein E; Region: type_II_gspE; TIGR02533
644801012905	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
644801012906	Walker A motif; other site
644801012907	ATP binding site [chemical binding]; other site
644801012908	Walker B motif; other site
644801012909	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
644801012910	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
644801012911	ligand binding site [chemical binding]; other site
644801012912	homodimer interface [polypeptide binding]; other site
644801012913	NAD(P) binding site [chemical binding]; other site
644801012914	trimer interface B [polypeptide binding]; other site
644801012915	trimer interface A [polypeptide binding]; other site
644801012916	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
644801012917	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
644801012918	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
644801012919	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
644801012920	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
644801012921	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
644801012922	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
644801012923	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
644801012924	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
644801012925	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
644801012926	conserverd hypothetical protein; Region: TIGR02448
644801012927	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
644801012928	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
644801012929	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
644801012930	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
644801012931	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
644801012932	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
644801012933	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
644801012934	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
644801012935	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
644801012936	DNA polymerase I; Provisional; Region: PRK05755
644801012937	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
644801012938	active site
644801012939	metal binding site 1 [ion binding]; metal-binding site
644801012940	putative 5' ssDNA interaction site; other site
644801012941	metal binding site 3; metal-binding site
644801012942	metal binding site 2 [ion binding]; metal-binding site
644801012943	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
644801012944	putative DNA binding site [nucleotide binding]; other site
644801012945	putative metal binding site [ion binding]; other site
644801012946	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
644801012947	active site
644801012948	catalytic site [active]
644801012949	substrate binding site [chemical binding]; other site
644801012950	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
644801012951	active site
644801012952	DNA binding site [nucleotide binding]
644801012953	catalytic site [active]
644801012954	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
644801012955	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
644801012956	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
644801012957	putative active site [active]
644801012958	putative substrate binding site [chemical binding]; other site
644801012959	ATP binding site [chemical binding]; other site
644801012960	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
644801012961	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
644801012962	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
644801012963	EamA-like transporter family; Region: EamA; cl17759
644801012964	TSCPD domain; Region: TSCPD; pfam12637
644801012965	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
644801012966	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
644801012967	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
644801012968	active site
644801012969	dimer interface [polypeptide binding]; other site
644801012970	effector binding site; other site
644801012971	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
644801012972	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
644801012973	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
644801012974	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
644801012975	acyl-activating enzyme (AAE) consensus motif; other site
644801012976	putative AMP binding site [chemical binding]; other site
644801012977	putative active site [active]
644801012978	putative CoA binding site [chemical binding]; other site
644801012979	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
644801012980	Transcriptional regulator [Transcription]; Region: IclR; COG1414
644801012981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801012982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801012983	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
644801012984	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
644801012985	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
644801012986	Major Facilitator Superfamily; Region: MFS_1; pfam07690
644801012987	putative substrate translocation pore; other site
644801012988	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
644801012989	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
644801012990	active site
644801012991	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
644801012992	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
644801012993	FAD binding site [chemical binding]; other site
644801012994	substrate binding site [chemical binding]; other site
644801012995	catalytic base [active]
644801012996	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
644801012997	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
644801012998	substrate binding site [chemical binding]; other site
644801012999	oxyanion hole (OAH) forming residues; other site
644801013000	trimer interface [polypeptide binding]; other site
644801013001	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
644801013002	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801013003	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
644801013004	Response regulator receiver domain; Region: Response_reg; pfam00072
644801013005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013006	active site
644801013007	phosphorylation site [posttranslational modification]
644801013008	intermolecular recognition site; other site
644801013009	dimerization interface [polypeptide binding]; other site
644801013010	HDOD domain; Region: HDOD; pfam08668
644801013011	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
644801013012	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
644801013013	tetramerization interface [polypeptide binding]; other site
644801013014	NAD(P) binding site [chemical binding]; other site
644801013015	catalytic residues [active]
644801013016	Cytochrome C' Region: Cytochrom_C_2; pfam01322
644801013017	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
644801013018	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
644801013019	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
644801013020	phosphopeptide binding site; other site
644801013021	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
644801013022	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
644801013023	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
644801013024	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
644801013025	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
644801013026	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
644801013027	G1 box; other site
644801013028	GTP/Mg2+ binding site [chemical binding]; other site
644801013029	G2 box; other site
644801013030	Switch I region; other site
644801013031	G3 box; other site
644801013032	Switch II region; other site
644801013033	G4 box; other site
644801013034	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
644801013035	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
644801013036	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
644801013037	active site
644801013038	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
644801013039	Catalytic domain of Protein Kinases; Region: PKc; cd00180
644801013040	active site
644801013041	ATP binding site [chemical binding]; other site
644801013042	substrate binding site [chemical binding]; other site
644801013043	activation loop (A-loop); other site
644801013044	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
644801013045	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
644801013046	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
644801013047	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
644801013048	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
644801013049	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
644801013050	putative heme binding pocket [chemical binding]; other site
644801013051	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
644801013052	Permease; Region: Permease; pfam02405
644801013053	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
644801013054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801013055	Walker A/P-loop; other site
644801013056	ATP binding site [chemical binding]; other site
644801013057	Q-loop/lid; other site
644801013058	ABC transporter signature motif; other site
644801013059	Walker B; other site
644801013060	D-loop; other site
644801013061	H-loop/switch region; other site
644801013062	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
644801013063	mce related protein; Region: MCE; pfam02470
644801013064	Protein of unknown function (DUF330); Region: DUF330; cl01135
644801013065	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
644801013066	HlyD family secretion protein; Region: HlyD_3; pfam13437
644801013067	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
644801013068	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
644801013069	Walker A/P-loop; other site
644801013070	ATP binding site [chemical binding]; other site
644801013071	Q-loop/lid; other site
644801013072	ABC transporter signature motif; other site
644801013073	Walker B; other site
644801013074	D-loop; other site
644801013075	H-loop/switch region; other site
644801013076	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
644801013077	Walker A/P-loop; other site
644801013078	ATP binding site [chemical binding]; other site
644801013079	Q-loop/lid; other site
644801013080	ABC transporter signature motif; other site
644801013081	Walker B; other site
644801013082	D-loop; other site
644801013083	H-loop/switch region; other site
644801013084	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
644801013085	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
644801013086	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
644801013087	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
644801013088	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
644801013089	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
644801013090	NAD binding site [chemical binding]; other site
644801013091	substrate binding site [chemical binding]; other site
644801013092	homodimer interface [polypeptide binding]; other site
644801013093	active site
644801013094	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
644801013095	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
644801013096	substrate binding site; other site
644801013097	tetramer interface; other site
644801013098	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
644801013099	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
644801013100	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
644801013101	NADP binding site [chemical binding]; other site
644801013102	active site
644801013103	putative substrate binding site [chemical binding]; other site
644801013104	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
644801013105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801013106	dimer interface [polypeptide binding]; other site
644801013107	phosphorylation site [posttranslational modification]
644801013108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801013109	ATP binding site [chemical binding]; other site
644801013110	G-X-G motif; other site
644801013111	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
644801013112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013113	active site
644801013114	phosphorylation site [posttranslational modification]
644801013115	intermolecular recognition site; other site
644801013116	dimerization interface [polypeptide binding]; other site
644801013117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
644801013118	Walker A motif; other site
644801013119	ATP binding site [chemical binding]; other site
644801013120	Walker B motif; other site
644801013121	arginine finger; other site
644801013122	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
644801013123	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
644801013124	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
644801013125	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
644801013126	DctM-like transporters; Region: DctM; pfam06808
644801013127	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
644801013128	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
644801013129	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
644801013130	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
644801013131	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
644801013132	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
644801013133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801013134	N-terminal plug; other site
644801013135	ligand-binding site [chemical binding]; other site
644801013136	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
644801013137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
644801013138	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
644801013139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801013140	Walker A/P-loop; other site
644801013141	ATP binding site [chemical binding]; other site
644801013142	Q-loop/lid; other site
644801013143	ABC transporter signature motif; other site
644801013144	Walker B; other site
644801013145	D-loop; other site
644801013146	H-loop/switch region; other site
644801013147	NnrS protein; Region: NnrS; pfam05940
644801013148	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
644801013149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801013150	dimer interface [polypeptide binding]; other site
644801013151	conserved gate region; other site
644801013152	putative PBP binding loops; other site
644801013153	ABC-ATPase subunit interface; other site
644801013154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801013155	dimer interface [polypeptide binding]; other site
644801013156	conserved gate region; other site
644801013157	putative PBP binding loops; other site
644801013158	ABC-ATPase subunit interface; other site
644801013159	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
644801013160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801013161	Walker A/P-loop; other site
644801013162	ATP binding site [chemical binding]; other site
644801013163	Q-loop/lid; other site
644801013164	ABC transporter signature motif; other site
644801013165	Walker B; other site
644801013166	D-loop; other site
644801013167	H-loop/switch region; other site
644801013168	TOBE domain; Region: TOBE_2; pfam08402
644801013169	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
644801013170	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
644801013171	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
644801013172	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
644801013173	putative aminotransferase; Validated; Region: PRK07480
644801013174	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801013175	inhibitor-cofactor binding pocket; inhibition site
644801013176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801013177	catalytic residue [active]
644801013178	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
644801013179	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
644801013180	Peptidase C26; Region: Peptidase_C26; pfam07722
644801013181	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
644801013182	catalytic triad [active]
644801013183	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
644801013184	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
644801013185	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
644801013186	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
644801013187	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
644801013188	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
644801013189	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
644801013190	putative active site; other site
644801013191	catalytic triad [active]
644801013192	putative dimer interface [polypeptide binding]; other site
644801013193	agmatine deiminase; Provisional; Region: PRK13551
644801013194	agmatine deiminase; Region: agmatine_aguA; TIGR03380
644801013195	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
644801013196	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801013197	active site
644801013198	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013199	PAS fold; Region: PAS_3; pfam08447
644801013200	putative active site [active]
644801013201	heme pocket [chemical binding]; other site
644801013202	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801013203	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801013204	metal binding site [ion binding]; metal-binding site
644801013205	active site
644801013206	I-site; other site
644801013207	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
644801013208	Fatty acid desaturase; Region: FA_desaturase; pfam00487
644801013209	Di-iron ligands [ion binding]; other site
644801013210	Transposase; Region: DDE_Tnp_ISL3; pfam01610
644801013211	PAS fold; Region: PAS_3; pfam08447
644801013212	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013213	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
644801013214	putative active site [active]
644801013215	heme pocket [chemical binding]; other site
644801013216	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
644801013217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013218	putative active site [active]
644801013219	heme pocket [chemical binding]; other site
644801013220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801013221	ATP binding site [chemical binding]; other site
644801013222	Mg2+ binding site [ion binding]; other site
644801013223	G-X-G motif; other site
644801013224	Response regulator receiver domain; Region: Response_reg; pfam00072
644801013225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013226	active site
644801013227	phosphorylation site [posttranslational modification]
644801013228	intermolecular recognition site; other site
644801013229	dimerization interface [polypeptide binding]; other site
644801013230	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
644801013231	GAF domain; Region: GAF; pfam01590
644801013232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013233	PAS domain; Region: PAS_9; pfam13426
644801013234	putative active site [active]
644801013235	heme pocket [chemical binding]; other site
644801013236	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013237	PAS fold; Region: PAS_3; pfam08447
644801013238	putative active site [active]
644801013239	heme pocket [chemical binding]; other site
644801013240	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
644801013241	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013242	putative active site [active]
644801013243	heme pocket [chemical binding]; other site
644801013244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801013245	dimer interface [polypeptide binding]; other site
644801013246	phosphorylation site [posttranslational modification]
644801013247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801013248	ATP binding site [chemical binding]; other site
644801013249	Mg2+ binding site [ion binding]; other site
644801013250	G-X-G motif; other site
644801013251	Response regulator receiver domain; Region: Response_reg; pfam00072
644801013252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013253	active site
644801013254	phosphorylation site [posttranslational modification]
644801013255	intermolecular recognition site; other site
644801013256	dimerization interface [polypeptide binding]; other site
644801013257	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
644801013258	putative binding surface; other site
644801013259	active site
644801013260	Response regulator receiver domain; Region: Response_reg; pfam00072
644801013261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013262	active site
644801013263	phosphorylation site [posttranslational modification]
644801013264	intermolecular recognition site; other site
644801013265	dimerization interface [polypeptide binding]; other site
644801013266	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
644801013267	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
644801013268	metal binding site [ion binding]; metal-binding site
644801013269	active site
644801013270	I-site; other site
644801013271	CHASE3 domain; Region: CHASE3; pfam05227
644801013272	PAS domain S-box; Region: sensory_box; TIGR00229
644801013273	PAS domain; Region: PAS; smart00091
644801013274	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801013275	dimer interface [polypeptide binding]; other site
644801013276	phosphorylation site [posttranslational modification]
644801013277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801013278	ATP binding site [chemical binding]; other site
644801013279	Mg2+ binding site [ion binding]; other site
644801013280	G-X-G motif; other site
644801013281	Response regulator receiver domain; Region: Response_reg; pfam00072
644801013282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013283	active site
644801013284	phosphorylation site [posttranslational modification]
644801013285	intermolecular recognition site; other site
644801013286	dimerization interface [polypeptide binding]; other site
644801013287	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801013288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013289	active site
644801013290	phosphorylation site [posttranslational modification]
644801013291	intermolecular recognition site; other site
644801013292	dimerization interface [polypeptide binding]; other site
644801013293	Response regulator receiver domain; Region: Response_reg; pfam00072
644801013294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013295	active site
644801013296	phosphorylation site [posttranslational modification]
644801013297	intermolecular recognition site; other site
644801013298	dimerization interface [polypeptide binding]; other site
644801013299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
644801013300	TPR motif; other site
644801013301	TPR repeat; Region: TPR_11; pfam13414
644801013302	binding surface
644801013303	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
644801013304	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
644801013305	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
644801013306	DXD motif; other site
644801013307	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
644801013308	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
644801013309	NAD(P) binding site [chemical binding]; other site
644801013310	catalytic residues [active]
644801013311	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
644801013312	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
644801013313	inhibitor-cofactor binding pocket; inhibition site
644801013314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
644801013315	catalytic residue [active]
644801013316	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
644801013317	intersubunit interface [polypeptide binding]; other site
644801013318	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
644801013319	metal binding site [ion binding]; metal-binding site
644801013320	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
644801013321	metal binding site 2 [ion binding]; metal-binding site
644801013322	putative DNA binding helix; other site
644801013323	metal binding site 1 [ion binding]; metal-binding site
644801013324	dimer interface [polypeptide binding]; other site
644801013325	structural Zn2+ binding site [ion binding]; other site
644801013326	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
644801013327	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
644801013328	Walker A/P-loop; other site
644801013329	ATP binding site [chemical binding]; other site
644801013330	Q-loop/lid; other site
644801013331	ABC transporter signature motif; other site
644801013332	Walker B; other site
644801013333	D-loop; other site
644801013334	H-loop/switch region; other site
644801013335	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
644801013336	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
644801013337	ABC-ATPase subunit  interface; other site
644801013338	dimer interface [polypeptide binding]; other site
644801013339	putative PBP binding regions; other site
644801013340	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
644801013341	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
644801013342	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
644801013343	transmembrane helices; other site
644801013344	hydroperoxidase II; Provisional; Region: katE; PRK11249
644801013345	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
644801013346	tetramer interface [polypeptide binding]; other site
644801013347	heme binding pocket [chemical binding]; other site
644801013348	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
644801013349	domain interactions; other site
644801013350	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
644801013351	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
644801013352	Walker A/P-loop; other site
644801013353	ATP binding site [chemical binding]; other site
644801013354	Q-loop/lid; other site
644801013355	ABC transporter signature motif; other site
644801013356	Walker B; other site
644801013357	D-loop; other site
644801013358	H-loop/switch region; other site
644801013359	NIL domain; Region: NIL; pfam09383
644801013360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
644801013361	dimer interface [polypeptide binding]; other site
644801013362	conserved gate region; other site
644801013363	ABC-ATPase subunit interface; other site
644801013364	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
644801013365	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
644801013366	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
644801013367	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
644801013368	putative NAD(P) binding site [chemical binding]; other site
644801013369	putative substrate binding site [chemical binding]; other site
644801013370	catalytic Zn binding site [ion binding]; other site
644801013371	structural Zn binding site [ion binding]; other site
644801013372	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
644801013373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
644801013374	putative metal binding site [ion binding]; other site
644801013375	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
644801013376	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
644801013377	trimer interface [polypeptide binding]; other site
644801013378	putative metal binding site [ion binding]; other site
644801013379	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
644801013380	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
644801013381	active site
644801013382	Zn binding site [ion binding]; other site
644801013383	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
644801013384	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
644801013385	Protein of unknown function; Region: DUF3658; pfam12395
644801013386	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
644801013387	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
644801013388	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
644801013389	FeS/SAM binding site; other site
644801013390	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
644801013391	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
644801013392	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
644801013393	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
644801013394	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
644801013395	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
644801013396	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
644801013397	Subunit I/III interface [polypeptide binding]; other site
644801013398	D-pathway; other site
644801013399	Subunit I/VIIc interface [polypeptide binding]; other site
644801013400	Subunit I/IV interface [polypeptide binding]; other site
644801013401	Subunit I/II interface [polypeptide binding]; other site
644801013402	Low-spin heme (heme a) binding site [chemical binding]; other site
644801013403	Subunit I/VIIa interface [polypeptide binding]; other site
644801013404	Subunit I/VIa interface [polypeptide binding]; other site
644801013405	Dimer interface; other site
644801013406	Putative water exit pathway; other site
644801013407	Binuclear center (heme a3/CuB) [ion binding]; other site
644801013408	K-pathway; other site
644801013409	Subunit I/Vb interface [polypeptide binding]; other site
644801013410	Putative proton exit pathway; other site
644801013411	Subunit I/VIb interface; other site
644801013412	Subunit I/VIc interface [polypeptide binding]; other site
644801013413	Electron transfer pathway; other site
644801013414	Subunit I/VIIIb interface [polypeptide binding]; other site
644801013415	Subunit I/VIIb interface [polypeptide binding]; other site
644801013416	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
644801013417	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
644801013418	Subunit III/VIIa interface [polypeptide binding]; other site
644801013419	Phospholipid binding site [chemical binding]; other site
644801013420	Subunit I/III interface [polypeptide binding]; other site
644801013421	Subunit III/VIb interface [polypeptide binding]; other site
644801013422	Subunit III/VIa interface; other site
644801013423	Subunit III/Vb interface [polypeptide binding]; other site
644801013424	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
644801013425	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
644801013426	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
644801013427	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
644801013428	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
644801013429	UbiA prenyltransferase family; Region: UbiA; pfam01040
644801013430	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
644801013431	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
644801013432	Cu(I) binding site [ion binding]; other site
644801013433	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
644801013434	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
644801013435	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
644801013436	Secretin and TonB N terminus short domain; Region: STN; smart00965
644801013437	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
644801013438	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
644801013439	N-terminal plug; other site
644801013440	ligand-binding site [chemical binding]; other site
644801013441	fec operon regulator FecR; Reviewed; Region: PRK09774
644801013442	FecR protein; Region: FecR; pfam04773
644801013443	RNA polymerase sigma factor; Provisional; Region: PRK12528
644801013444	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
644801013445	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
644801013446	DNA binding residues [nucleotide binding]
644801013447	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
644801013448	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
644801013449	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
644801013450	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
644801013451	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
644801013452	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
644801013453	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
644801013454	GAF domain; Region: GAF; pfam01590
644801013455	Phytochrome region; Region: PHY; pfam00360
644801013456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801013457	dimer interface [polypeptide binding]; other site
644801013458	phosphorylation site [posttranslational modification]
644801013459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801013460	ATP binding site [chemical binding]; other site
644801013461	Mg2+ binding site [ion binding]; other site
644801013462	G-X-G motif; other site
644801013463	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801013464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013465	active site
644801013466	phosphorylation site [posttranslational modification]
644801013467	intermolecular recognition site; other site
644801013468	dimerization interface [polypeptide binding]; other site
644801013469	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801013470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013471	active site
644801013472	phosphorylation site [posttranslational modification]
644801013473	intermolecular recognition site; other site
644801013474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013475	PAS fold; Region: PAS_3; pfam08447
644801013476	putative active site [active]
644801013477	heme pocket [chemical binding]; other site
644801013478	PAS domain S-box; Region: sensory_box; TIGR00229
644801013479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
644801013480	putative active site [active]
644801013481	heme pocket [chemical binding]; other site
644801013482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
644801013483	dimer interface [polypeptide binding]; other site
644801013484	phosphorylation site [posttranslational modification]
644801013485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
644801013486	ATP binding site [chemical binding]; other site
644801013487	Mg2+ binding site [ion binding]; other site
644801013488	G-X-G motif; other site
644801013489	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
644801013490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
644801013491	active site
644801013492	phosphorylation site [posttranslational modification]
644801013493	intermolecular recognition site; other site
644801013494	dimerization interface [polypeptide binding]; other site
644801013495	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
644801013496	heme binding pocket [chemical binding]; other site
644801013497	heme ligand [chemical binding]; other site
644801013498	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
644801013499	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
644801013500	glutaminase active site [active]
644801013501	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
644801013502	dimer interface [polypeptide binding]; other site
644801013503	active site
644801013504	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
644801013505	dimer interface [polypeptide binding]; other site
644801013506	active site
644801013507	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
644801013508	putative DNA binding site [nucleotide binding]; other site
644801013509	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
644801013510	putative Zn2+ binding site [ion binding]; other site
644801013511	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
644801013512	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
644801013513	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
644801013514	Substrate binding site; other site
644801013515	Mg++ binding site; other site
644801013516	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
644801013517	active site
644801013518	substrate binding site [chemical binding]; other site
644801013519	CoA binding site [chemical binding]; other site
644801013520	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
644801013521	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
644801013522	gamma subunit interface [polypeptide binding]; other site
644801013523	epsilon subunit interface [polypeptide binding]; other site
644801013524	LBP interface [polypeptide binding]; other site
644801013525	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
644801013526	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
644801013527	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
644801013528	alpha subunit interaction interface [polypeptide binding]; other site
644801013529	Walker A motif; other site
644801013530	ATP binding site [chemical binding]; other site
644801013531	Walker B motif; other site
644801013532	inhibitor binding site; inhibition site
644801013533	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
644801013534	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
644801013535	core domain interface [polypeptide binding]; other site
644801013536	delta subunit interface [polypeptide binding]; other site
644801013537	epsilon subunit interface [polypeptide binding]; other site
644801013538	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
644801013539	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
644801013540	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
644801013541	beta subunit interaction interface [polypeptide binding]; other site
644801013542	Walker A motif; other site
644801013543	ATP binding site [chemical binding]; other site
644801013544	Walker B motif; other site
644801013545	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
644801013546	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
644801013547	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
644801013548	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
644801013549	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
644801013550	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
644801013551	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
644801013552	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
644801013553	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
644801013554	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
644801013555	ParB-like nuclease domain; Region: ParBc; pfam02195
644801013556	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
644801013557	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801013558	P-loop; other site
644801013559	Magnesium ion binding site [ion binding]; other site
644801013560	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801013561	Magnesium ion binding site [ion binding]; other site
644801013562	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
644801013563	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
644801013564	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
644801013565	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
644801013566	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
644801013567	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
644801013568	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
644801013569	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
644801013570	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801013571	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
644801013572	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
644801013573	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
644801013574	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
644801013575	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
644801013576	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
644801013577	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
644801013578	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
644801013579	trmE is a tRNA modification GTPase; Region: trmE; cd04164
644801013580	G1 box; other site
644801013581	GTP/Mg2+ binding site [chemical binding]; other site
644801013582	Switch I region; other site
644801013583	G2 box; other site
644801013584	Switch II region; other site
644801013585	G3 box; other site
644801013586	G4 box; other site
644801013587	G5 box; other site
644801013588	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
644801013589	membrane protein insertase; Provisional; Region: PRK01318
644801013590	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
644801013591	Haemolytic domain; Region: Haemolytic; cl00506
644801013592	ribonuclease P; Reviewed; Region: rnpA; PRK00396
644801013593	stationary phase growth adaptation protein; Provisional; Region: PRK09717
644801013594	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
644801013595	dimerization interface [polypeptide binding]; other site
644801013596	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
644801013597	multiple promoter invertase; Provisional; Region: mpi; PRK13413
644801013598	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
644801013599	catalytic residues [active]
644801013600	catalytic nucleophile [active]
644801013601	Presynaptic Site I dimer interface [polypeptide binding]; other site
644801013602	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
644801013603	Synaptic Flat tetramer interface [polypeptide binding]; other site
644801013604	Synaptic Site I dimer interface [polypeptide binding]; other site
644801013605	DNA binding site [nucleotide binding]
644801013606	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
644801013607	DNA-binding interface [nucleotide binding]; DNA binding site
644801013608	multiple promoter invertase; Provisional; Region: mpi; PRK13413
644801013609	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
644801013610	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
644801013611	ParA-like protein; Provisional; Region: PHA02518
644801013612	P-loop; other site
644801013613	Magnesium ion binding site [ion binding]; other site
644801013614	ParG; Region: ParG; pfam09274
644801013615	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
644801013616	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
644801013617	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
644801013618	catalytic residues [active]
644801013619	catalytic nucleophile [active]
644801013620	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
644801013621	Virulence-associated protein E; Region: VirE; pfam05272
644801013622	Protein of unknown function (DUF3924); Region: DUF3924; pfam13062
644801013623	Helix-turn-helix domain; Region: HTH_39; pfam14090
644801013624	Terminase small subunit; Region: Terminase_2; cl01513
644801013625	Replication protein; Region: Rep_1; cl02412