-- dump date 20140620_020042 -- class Genbank::misc_feature -- table misc_feature_note -- id note 205918000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 205918000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918000004 Walker A motif; other site 205918000005 ATP binding site [chemical binding]; other site 205918000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 205918000007 Walker B motif; other site 205918000008 arginine finger; other site 205918000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 205918000010 DnaA box-binding interface [nucleotide binding]; other site 205918000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 205918000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 205918000013 putative DNA binding surface [nucleotide binding]; other site 205918000014 dimer interface [polypeptide binding]; other site 205918000015 beta-clamp/clamp loader binding surface; other site 205918000016 beta-clamp/translesion DNA polymerase binding surface; other site 205918000017 recombination protein F; Reviewed; Region: recF; PRK00064 205918000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918000019 Walker A/P-loop; other site 205918000020 ATP binding site [chemical binding]; other site 205918000021 Q-loop/lid; other site 205918000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918000023 ABC transporter signature motif; other site 205918000024 Walker B; other site 205918000025 D-loop; other site 205918000026 H-loop/switch region; other site 205918000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 205918000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918000029 ATP binding site [chemical binding]; other site 205918000030 Mg2+ binding site [ion binding]; other site 205918000031 G-X-G motif; other site 205918000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205918000033 anchoring element; other site 205918000034 dimer interface [polypeptide binding]; other site 205918000035 ATP binding site [chemical binding]; other site 205918000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 205918000037 active site 205918000038 putative metal-binding site [ion binding]; other site 205918000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205918000040 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 205918000041 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 205918000042 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918000043 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 205918000044 putative active site [active] 205918000045 catalytic triad [active] 205918000046 putative dimer interface [polypeptide binding]; other site 205918000047 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 205918000048 Cupin domain; Region: Cupin_2; cl17218 205918000049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918000050 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918000051 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918000052 putative acyl-acceptor binding pocket; other site 205918000053 1 probable transmembrane helix predicted by TMHMM2.0 205918000054 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 205918000055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918000056 active site 205918000057 motif I; other site 205918000058 motif II; other site 205918000059 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 205918000060 HD domain; Region: HD; pfam01966 205918000061 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205918000062 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 205918000063 dimer interface [polypeptide binding]; other site 205918000064 motif 1; other site 205918000065 active site 205918000066 motif 2; other site 205918000067 motif 3; other site 205918000068 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 205918000069 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 205918000070 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 205918000071 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 205918000072 putative acyl-acceptor binding pocket; other site 205918000073 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 205918000074 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 205918000075 putative molybdopterin cofactor binding site [chemical binding]; other site 205918000076 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 205918000077 putative molybdopterin cofactor binding site; other site 205918000078 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 205918000079 TrkA-N domain; Region: TrkA_N; pfam02254 205918000080 TrkA-C domain; Region: TrkA_C; pfam02080 205918000081 TrkA-N domain; Region: TrkA_N; pfam02254 205918000082 TrkA-C domain; Region: TrkA_C; pfam02080 205918000083 16S rRNA methyltransferase B; Provisional; Region: PRK10901 205918000084 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 205918000085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918000086 S-adenosylmethionine binding site [chemical binding]; other site 205918000087 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 205918000088 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 205918000089 putative active site [active] 205918000090 substrate binding site [chemical binding]; other site 205918000091 putative cosubstrate binding site; other site 205918000092 catalytic site [active] 205918000093 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 205918000094 substrate binding site [chemical binding]; other site 205918000095 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205918000096 active site 205918000097 catalytic residues [active] 205918000098 metal binding site [ion binding]; metal-binding site 205918000099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918000100 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 205918000101 DNA protecting protein DprA; Region: dprA; TIGR00732 205918000102 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 205918000103 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 205918000104 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 205918000105 NADP binding site [chemical binding]; other site 205918000106 dimer interface [polypeptide binding]; other site 205918000107 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 205918000108 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 205918000109 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 205918000110 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205918000111 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205918000112 NAD(P) binding site [chemical binding]; other site 205918000113 shikimate binding site; other site 205918000114 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 205918000115 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 205918000116 Sulfate transporter family; Region: Sulfate_transp; pfam00916 205918000117 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 205918000118 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000119 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000120 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000121 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000122 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000123 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000124 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000125 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000126 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000127 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000128 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000129 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 205918000130 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 205918000131 Sulfatase; Region: Sulfatase; cl17466 205918000132 choline-sulfatase; Region: chol_sulfatase; TIGR03417 205918000133 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 205918000134 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 205918000135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918000136 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 205918000137 dimerization interface [polypeptide binding]; other site 205918000138 substrate binding pocket [chemical binding]; other site 205918000139 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918000140 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 205918000141 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 205918000142 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 205918000143 substrate binding site [chemical binding]; other site 205918000144 active site 205918000145 catalytic residues [active] 205918000146 heterodimer interface [polypeptide binding]; other site 205918000147 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 205918000148 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 205918000149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000150 catalytic residue [active] 205918000151 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918000152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918000153 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 205918000154 putative dimerization interface [polypeptide binding]; other site 205918000155 putative substrate binding pocket [chemical binding]; other site 205918000156 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 205918000157 1 probable transmembrane helix predicted by TMHMM2.0 205918000158 Dodecin; Region: Dodecin; pfam07311 205918000159 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 205918000160 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 205918000161 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918000162 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 205918000163 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 205918000164 1 probable transmembrane helix predicted by TMHMM2.0 205918000165 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 205918000166 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 205918000167 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 205918000168 trimer interface [polypeptide binding]; other site 205918000169 putative metal binding site [ion binding]; other site 205918000170 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 205918000171 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 205918000172 active site 205918000173 Zn binding site [ion binding]; other site 205918000174 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 205918000175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 205918000176 Cytochrome c; Region: Cytochrom_C; pfam00034 205918000177 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 205918000178 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000179 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000180 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000181 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000182 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000183 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000184 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000185 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000186 LysE type translocator; Region: LysE; cl00565 205918000187 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000188 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000189 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000190 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000191 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000192 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205918000193 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918000194 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000195 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000196 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000197 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 205918000198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918000199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918000200 ABC transporter; Region: ABC_tran_2; pfam12848 205918000201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918000202 TIGR02444 family protein; Region: TIGR02444 205918000203 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 205918000204 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 205918000205 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918000206 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 205918000207 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 205918000208 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000209 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000210 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000211 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000212 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 205918000213 HemY protein N-terminus; Region: HemY_N; pfam07219 205918000214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918000215 binding surface 205918000216 TPR motif; other site 205918000217 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000218 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000219 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 205918000220 1 probable transmembrane helix predicted by TMHMM2.0 205918000221 uroporphyrinogen-III synthase; Validated; Region: PRK05752 205918000222 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 205918000223 active site 205918000224 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 205918000225 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 205918000226 domain interfaces; other site 205918000227 active site 205918000228 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 205918000229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918000230 active site 205918000231 phosphorylation site [posttranslational modification] 205918000232 intermolecular recognition site; other site 205918000233 dimerization interface [polypeptide binding]; other site 205918000234 LytTr DNA-binding domain; Region: LytTR; pfam04397 205918000235 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 205918000236 Histidine kinase; Region: His_kinase; pfam06580 205918000237 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000238 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000239 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000240 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000241 argininosuccinate lyase; Provisional; Region: PRK00855 205918000242 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 205918000243 active sites [active] 205918000244 tetramer interface [polypeptide binding]; other site 205918000245 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 205918000246 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 205918000247 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000248 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000249 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000250 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000251 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000252 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000253 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000254 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000255 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000256 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 205918000257 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000258 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000259 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000260 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000261 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000262 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000263 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205918000264 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918000265 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918000266 1 probable transmembrane helix predicted by TMHMM2.0 205918000267 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 205918000268 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 205918000269 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 205918000270 PhoU domain; Region: PhoU; pfam01895 205918000271 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000272 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000273 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000274 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000275 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000276 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000277 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000278 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918000280 dimerization interface [polypeptide binding]; other site 205918000281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918000282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918000283 dimer interface [polypeptide binding]; other site 205918000284 putative CheW interface [polypeptide binding]; other site 205918000285 1 probable transmembrane helix predicted by TMHMM2.0 205918000286 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918000287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918000288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918000289 dimerization interface [polypeptide binding]; other site 205918000290 multidrug efflux protein NorA; Provisional; Region: PRK00187 205918000291 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 205918000292 cation binding site [ion binding]; other site 205918000293 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000294 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000295 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000296 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000297 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000298 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000299 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000300 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000301 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000302 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000303 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000304 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918000306 metal binding site [ion binding]; metal-binding site 205918000307 active site 205918000308 I-site; other site 205918000309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918000310 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 205918000311 Family description; Region: UvrD_C_2; pfam13538 205918000312 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918000313 active site 205918000314 PAS domain; Region: PAS_9; pfam13426 205918000315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918000316 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918000317 Walker A motif; other site 205918000318 ATP binding site [chemical binding]; other site 205918000319 Walker B motif; other site 205918000320 arginine finger; other site 205918000321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918000322 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 205918000323 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 205918000324 1 probable transmembrane helix predicted by TMHMM2.0 205918000325 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205918000326 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000327 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000328 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000329 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000330 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000331 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000332 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000333 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000334 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 205918000335 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 205918000336 Walker A/P-loop; other site 205918000337 ATP binding site [chemical binding]; other site 205918000338 Q-loop/lid; other site 205918000339 ABC transporter signature motif; other site 205918000340 Walker B; other site 205918000341 D-loop; other site 205918000342 H-loop/switch region; other site 205918000343 TOBE-like domain; Region: TOBE_3; pfam12857 205918000344 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205918000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000346 dimer interface [polypeptide binding]; other site 205918000347 conserved gate region; other site 205918000348 putative PBP binding loops; other site 205918000349 ABC-ATPase subunit interface; other site 205918000350 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000351 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000352 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000353 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000354 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000355 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000356 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205918000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000358 dimer interface [polypeptide binding]; other site 205918000359 conserved gate region; other site 205918000360 putative PBP binding loops; other site 205918000361 ABC-ATPase subunit interface; other site 205918000362 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000363 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000364 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000365 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000366 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000367 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000368 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 205918000369 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918000370 Uncharacterized small protein [Function unknown]; Region: COG5583 205918000371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918000372 PAS domain; Region: PAS_9; pfam13426 205918000373 putative active site [active] 205918000374 heme pocket [chemical binding]; other site 205918000375 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918000376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918000377 metal binding site [ion binding]; metal-binding site 205918000378 active site 205918000379 I-site; other site 205918000380 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918000381 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000382 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000383 Fatty acid desaturase; Region: FA_desaturase; pfam00487 205918000384 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 205918000385 Di-iron ligands [ion binding]; other site 205918000386 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 205918000387 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205918000388 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000389 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918000391 PAS fold; Region: PAS_3; pfam08447 205918000392 putative active site [active] 205918000393 heme pocket [chemical binding]; other site 205918000394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918000395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918000396 metal binding site [ion binding]; metal-binding site 205918000397 active site 205918000398 I-site; other site 205918000399 Response regulator receiver domain; Region: Response_reg; pfam00072 205918000400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918000401 active site 205918000402 phosphorylation site [posttranslational modification] 205918000403 intermolecular recognition site; other site 205918000404 dimerization interface [polypeptide binding]; other site 205918000405 HDOD domain; Region: HDOD; pfam08668 205918000406 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 205918000407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918000408 inhibitor-cofactor binding pocket; inhibition site 205918000409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000410 catalytic residue [active] 205918000411 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 205918000412 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 205918000413 tetramerization interface [polypeptide binding]; other site 205918000414 NAD(P) binding site [chemical binding]; other site 205918000415 catalytic residues [active] 205918000416 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918000417 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000418 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000419 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000420 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000421 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000422 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000423 hypothetical protein; Provisional; Region: PRK07236 205918000424 hypothetical protein; Provisional; Region: PRK07588 205918000425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 205918000426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 205918000427 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 205918000428 Transposase domain (DUF772); Region: DUF772; pfam05598 205918000429 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 205918000430 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 205918000431 SIR2-like domain; Region: SIR2_2; pfam13289 205918000432 Domain of unknown function DUF87; Region: DUF87; pfam01935 205918000433 HerA helicase [Replication, recombination, and repair]; Region: COG0433 205918000434 KTSC domain; Region: KTSC; pfam13619 205918000435 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 205918000436 Protein of unknown function (DUF796); Region: DUF796; pfam05638 205918000437 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 205918000438 TIR domain; Region: TIR_2; pfam13676 205918000439 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 205918000440 putative transposase OrfB; Reviewed; Region: PHA02517 205918000441 HTH-like domain; Region: HTH_21; pfam13276 205918000442 Integrase core domain; Region: rve; pfam00665 205918000443 Integrase core domain; Region: rve_2; pfam13333 205918000444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918000445 Transposase; Region: HTH_Tnp_1; pfam01527 205918000446 polyol permease family; Region: 2A0118; TIGR00897 205918000447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918000448 putative substrate translocation pore; other site 205918000449 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000450 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000451 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000452 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000453 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000454 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000455 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000456 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000457 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000458 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000459 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000460 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000461 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 205918000462 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000463 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000464 Protein of unknown function DUF262; Region: DUF262; pfam03235 205918000465 1 probable transmembrane helix predicted by TMHMM2.0 205918000466 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000467 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000468 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000469 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000470 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000471 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000472 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000473 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000474 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918000475 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000476 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000477 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000478 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000479 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000480 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000481 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 205918000482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918000483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000484 homodimer interface [polypeptide binding]; other site 205918000485 catalytic residue [active] 205918000486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918000487 S-adenosylmethionine binding site [chemical binding]; other site 205918000488 ISPs1, transposase OrfB 205918000489 C factor cell-cell signaling protein; Provisional; Region: PRK09009 205918000490 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 205918000491 NADP binding site [chemical binding]; other site 205918000492 homodimer interface [polypeptide binding]; other site 205918000493 active site 205918000494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918000495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918000496 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 205918000497 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918000498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000499 short chain dehydrogenase; Validated; Region: PRK07069 205918000500 NAD(P) binding site [chemical binding]; other site 205918000501 active site 205918000502 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918000503 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918000504 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 205918000505 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000506 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000507 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000508 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 205918000509 Protein of unknown function (DUF805); Region: DUF805; pfam05656 205918000510 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000511 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000512 Uncharacterized conserved protein [Function unknown]; Region: COG3791 205918000513 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000514 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000515 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000516 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205918000517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918000518 motif II; other site 205918000519 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918000520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918000521 putative DNA binding site [nucleotide binding]; other site 205918000522 putative Zn2+ binding site [ion binding]; other site 205918000523 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000524 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918000525 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 205918000526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918000527 catalytic residue [active] 205918000528 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918000529 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918000530 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 205918000531 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000532 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000533 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000534 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918000535 TolR protein; Region: tolR; TIGR02801 205918000536 1 probable transmembrane helix predicted by TMHMM2.0 205918000537 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 205918000538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918000539 N-terminal plug; other site 205918000540 ligand-binding site [chemical binding]; other site 205918000541 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918000542 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918000543 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 205918000544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000545 dimer interface [polypeptide binding]; other site 205918000546 conserved gate region; other site 205918000547 putative PBP binding loops; other site 205918000548 ABC-ATPase subunit interface; other site 205918000549 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000550 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000551 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000552 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000553 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000554 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000555 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 205918000556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000557 dimer interface [polypeptide binding]; other site 205918000558 conserved gate region; other site 205918000559 putative PBP binding loops; other site 205918000560 ABC-ATPase subunit interface; other site 205918000561 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000562 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000563 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000564 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000565 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000566 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 205918000567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918000568 Walker A/P-loop; other site 205918000569 ATP binding site [chemical binding]; other site 205918000570 Q-loop/lid; other site 205918000571 ABC transporter signature motif; other site 205918000572 Walker B; other site 205918000573 D-loop; other site 205918000574 H-loop/switch region; other site 205918000575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 205918000576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918000577 Walker A/P-loop; other site 205918000578 ATP binding site [chemical binding]; other site 205918000579 Q-loop/lid; other site 205918000580 ABC transporter signature motif; other site 205918000581 Walker B; other site 205918000582 D-loop; other site 205918000583 H-loop/switch region; other site 205918000584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918000585 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918000586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918000587 dimer interface [polypeptide binding]; other site 205918000588 putative CheW interface [polypeptide binding]; other site 205918000589 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000590 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000591 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000592 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000593 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918000594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918000595 putative DNA binding site [nucleotide binding]; other site 205918000596 putative Zn2+ binding site [ion binding]; other site 205918000597 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000598 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 205918000599 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 205918000600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918000601 inhibitor-cofactor binding pocket; inhibition site 205918000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000603 catalytic residue [active] 205918000604 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205918000605 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 205918000606 putative ligand binding site [chemical binding]; other site 205918000607 NAD binding site [chemical binding]; other site 205918000608 dimerization interface [polypeptide binding]; other site 205918000609 catalytic site [active] 205918000610 succinic semialdehyde dehydrogenase; Region: PLN02278 205918000611 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 205918000612 tetramerization interface [polypeptide binding]; other site 205918000613 NAD(P) binding site [chemical binding]; other site 205918000614 catalytic residues [active] 205918000615 acetylornithine deacetylase; Provisional; Region: PRK07522 205918000616 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 205918000617 metal binding site [ion binding]; metal-binding site 205918000618 putative dimer interface [polypeptide binding]; other site 205918000619 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918000620 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918000621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 205918000622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918000623 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 205918000624 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 205918000625 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205918000626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918000627 Walker A/P-loop; other site 205918000628 ATP binding site [chemical binding]; other site 205918000629 Q-loop/lid; other site 205918000630 ABC transporter signature motif; other site 205918000631 Walker B; other site 205918000632 D-loop; other site 205918000633 H-loop/switch region; other site 205918000634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918000635 Walker A/P-loop; other site 205918000636 ATP binding site [chemical binding]; other site 205918000637 Q-loop/lid; other site 205918000638 ABC transporter signature motif; other site 205918000639 Walker B; other site 205918000640 D-loop; other site 205918000641 H-loop/switch region; other site 205918000642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918000643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205918000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000645 dimer interface [polypeptide binding]; other site 205918000646 conserved gate region; other site 205918000647 ABC-ATPase subunit interface; other site 205918000648 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000649 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000650 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000651 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000652 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918000653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000654 dimer interface [polypeptide binding]; other site 205918000655 conserved gate region; other site 205918000656 putative PBP binding loops; other site 205918000657 ABC-ATPase subunit interface; other site 205918000658 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000659 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000660 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000661 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000662 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000663 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000664 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918000665 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 205918000666 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918000667 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918000668 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 205918000669 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 205918000670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918000671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918000672 Coenzyme A binding pocket [chemical binding]; other site 205918000673 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 205918000674 1 probable transmembrane helix predicted by TMHMM2.0 205918000675 1 probable transmembrane helix predicted by TMHMM2.0 205918000676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918000677 Coenzyme A binding pocket [chemical binding]; other site 205918000678 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 205918000679 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 205918000680 active site 205918000681 substrate-binding site [chemical binding]; other site 205918000682 metal-binding site [ion binding] 205918000683 ATP binding site [chemical binding]; other site 205918000684 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 205918000685 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 205918000686 dimerization interface [polypeptide binding]; other site 205918000687 domain crossover interface; other site 205918000688 redox-dependent activation switch; other site 205918000689 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918000690 RNA binding surface [nucleotide binding]; other site 205918000691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918000692 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 205918000693 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 205918000694 RimK-like ATP-grasp domain; Region: RimK; pfam08443 205918000695 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 205918000696 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 205918000697 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000698 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000699 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000700 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000701 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000702 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000703 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000704 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000705 TIGR02647 family protein; Region: DNA 205918000706 adenylate cyclase; Provisional; Region: cyaA; PRK09450 205918000707 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 205918000708 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 205918000709 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 205918000710 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918000711 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 205918000712 frataxin-like protein; Provisional; Region: cyaY; PRK00446 205918000713 putative iron binding site [ion binding]; other site 205918000714 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 205918000715 1 probable transmembrane helix predicted by TMHMM2.0 205918000716 diaminopimelate decarboxylase; Region: lysA; TIGR01048 205918000717 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 205918000718 active site 205918000719 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918000720 substrate binding site [chemical binding]; other site 205918000721 catalytic residues [active] 205918000722 dimer interface [polypeptide binding]; other site 205918000723 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 205918000724 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205918000725 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205918000726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3159 205918000727 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918000728 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 205918000729 active site 205918000730 Int/Topo IB signature motif; other site 205918000731 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 205918000732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918000733 motif II; other site 205918000734 Uncharacterized conserved protein [Function unknown]; Region: COG0432 205918000735 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 205918000736 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000737 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000738 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000739 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000740 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000741 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000742 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000743 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000744 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000748 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 205918000749 Nitrogen regulatory protein P-II; Region: P-II; smart00938 205918000750 Membrane fusogenic activity; Region: BMFP; pfam04380 205918000751 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918000752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918000753 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918000754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918000755 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 205918000756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000757 NAD(P) binding site [chemical binding]; other site 205918000758 active site 205918000759 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000760 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000761 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000762 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000763 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000764 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000765 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000766 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000767 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 205918000768 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 205918000769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918000770 Walker A motif; other site 205918000771 ATP binding site [chemical binding]; other site 205918000772 Walker B motif; other site 205918000773 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 205918000774 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 205918000775 Citrate transporter; Region: CitMHS; pfam03600 205918000776 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000777 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000778 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000779 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000780 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000781 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000782 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000783 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000784 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000785 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000786 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000787 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000788 Uncharacterized conserved protein [Function unknown]; Region: COG3791 205918000789 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 205918000790 putative deacylase active site [active] 205918000791 HDOD domain; Region: HDOD; pfam08668 205918000792 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 205918000793 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 205918000794 generic binding surface II; other site 205918000795 ssDNA binding site; other site 205918000796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918000797 ATP binding site [chemical binding]; other site 205918000798 putative Mg++ binding site [ion binding]; other site 205918000799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918000800 nucleotide binding region [chemical binding]; other site 205918000801 ATP-binding site [chemical binding]; other site 205918000802 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 205918000803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918000804 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 205918000805 dimerization interface [polypeptide binding]; other site 205918000806 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918000807 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918000808 1 probable transmembrane helix predicted by TMHMM2.0 205918000809 biopolymer transport protein ExbD; Provisional; Region: PRK11267 205918000810 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918000811 1 probable transmembrane helix predicted by TMHMM2.0 205918000812 tonB-system energizer ExbB; Region: exbB; TIGR02797 205918000813 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000814 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000815 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000816 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000817 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918000818 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 205918000819 putative NAD(P) binding site [chemical binding]; other site 205918000820 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918000821 homotrimer interaction site [polypeptide binding]; other site 205918000822 putative active site [active] 205918000823 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 205918000824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205918000825 Zn2+ binding site [ion binding]; other site 205918000826 Mg2+ binding site [ion binding]; other site 205918000827 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205918000828 synthetase active site [active] 205918000829 NTP binding site [chemical binding]; other site 205918000830 metal binding site [ion binding]; metal-binding site 205918000831 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 205918000832 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 205918000833 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 205918000834 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 205918000835 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 205918000836 catalytic site [active] 205918000837 G-X2-G-X-G-K; other site 205918000838 hypothetical protein; Provisional; Region: PRK11820 205918000839 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 205918000840 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 205918000841 ribonuclease PH; Reviewed; Region: rph; PRK00173 205918000842 Ribonuclease PH; Region: RNase_PH_bact; cd11362 205918000843 hexamer interface [polypeptide binding]; other site 205918000844 active site 205918000845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 205918000846 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000847 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000848 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000849 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 205918000850 putative active site [active] 205918000851 putative catalytic site [active] 205918000852 putative DNA binding site [nucleotide binding]; other site 205918000853 putative phosphate binding site [ion binding]; other site 205918000854 metal binding site A [ion binding]; metal-binding site 205918000855 putative AP binding site [nucleotide binding]; other site 205918000856 putative metal binding site B [ion binding]; other site 205918000857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918000858 active site 205918000859 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 205918000860 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 205918000861 feedback inhibition sensing region; other site 205918000862 homohexameric interface [polypeptide binding]; other site 205918000863 nucleotide binding site [chemical binding]; other site 205918000864 N-acetyl-L-glutamate binding site [chemical binding]; other site 205918000865 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 205918000866 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 205918000867 active site 205918000868 substrate binding site [chemical binding]; other site 205918000869 metal binding site [ion binding]; metal-binding site 205918000870 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205918000871 trimer interface [polypeptide binding]; other site 205918000872 active site 205918000873 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 205918000874 Flavoprotein; Region: Flavoprotein; pfam02441 205918000875 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 205918000876 hypothetical protein; Reviewed; Region: PRK00024 205918000877 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 205918000878 MPN+ (JAMM) motif; other site 205918000879 Zinc-binding site [ion binding]; other site 205918000880 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918000881 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918000882 peptide binding site [polypeptide binding]; other site 205918000883 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 205918000884 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 205918000885 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 205918000886 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 205918000887 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 205918000888 NAD(P) binding site [chemical binding]; other site 205918000889 catalytic residues [active] 205918000890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918000891 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000892 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000893 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000894 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000895 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000896 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000897 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000898 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000899 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000900 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000901 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000902 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000903 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 205918000904 PLD-like domain; Region: PLDc_2; pfam13091 205918000905 putative active site [active] 205918000906 catalytic site [active] 205918000907 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 205918000908 PLD-like domain; Region: PLDc_2; pfam13091 205918000909 putative active site [active] 205918000910 catalytic site [active] 205918000911 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918000912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918000913 DNA-binding site [nucleotide binding]; DNA binding site 205918000914 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918000915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000916 homodimer interface [polypeptide binding]; other site 205918000917 catalytic residue [active] 205918000918 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 205918000919 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918000920 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918000921 Flagellin N-methylase; Region: FliB; pfam03692 205918000922 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 205918000923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918000924 putative DNA binding site [nucleotide binding]; other site 205918000925 putative Zn2+ binding site [ion binding]; other site 205918000926 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000927 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 205918000928 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 205918000929 hydroxyglutarate oxidase; Provisional; Region: PRK11728 205918000930 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 205918000931 homotrimer interaction site [polypeptide binding]; other site 205918000932 putative active site [active] 205918000933 alanine racemase; Reviewed; Region: dadX; PRK03646 205918000934 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 205918000935 active site 205918000936 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918000937 substrate binding site [chemical binding]; other site 205918000938 catalytic residues [active] 205918000939 dimer interface [polypeptide binding]; other site 205918000940 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 205918000941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918000942 non-specific DNA binding site [nucleotide binding]; other site 205918000943 salt bridge; other site 205918000944 sequence-specific DNA binding site [nucleotide binding]; other site 205918000945 Cupin domain; Region: Cupin_2; pfam07883 205918000946 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 205918000947 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 205918000948 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 205918000949 Predicted membrane protein [Function unknown]; Region: COG4539 205918000950 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000951 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000952 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000953 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000954 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000955 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 205918000956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918000957 ligand binding site [chemical binding]; other site 205918000958 flexible hinge region; other site 205918000959 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 205918000960 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205918000961 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918000962 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 205918000963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000964 dimer interface [polypeptide binding]; other site 205918000965 conserved gate region; other site 205918000966 putative PBP binding loops; other site 205918000967 ABC-ATPase subunit interface; other site 205918000968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000969 dimer interface [polypeptide binding]; other site 205918000970 conserved gate region; other site 205918000971 putative PBP binding loops; other site 205918000972 ABC-ATPase subunit interface; other site 205918000973 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000974 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000975 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000976 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000977 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000978 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000979 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000980 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000981 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000982 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000983 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000984 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000985 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 205918000986 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918000987 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 205918000988 lipoyl attachment site [posttranslational modification]; other site 205918000989 conserverd hypothetical protein; Region: TIGR02448 205918000990 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918000991 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 205918000992 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918000993 Walker A motif; other site 205918000994 ATP binding site [chemical binding]; other site 205918000995 Walker B motif; other site 205918000996 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918000997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918000998 putative DNA binding site [nucleotide binding]; other site 205918000999 putative Zn2+ binding site [ion binding]; other site 205918001000 AsnC family; Region: AsnC_trans_reg; pfam01037 205918001001 Uncharacterized conserved protein [Function unknown]; Region: COG3025 205918001002 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 205918001003 putative active site [active] 205918001004 putative metal binding residues [ion binding]; other site 205918001005 signature motif; other site 205918001006 putative triphosphate binding site [ion binding]; other site 205918001007 acetylornithine deacetylase; Provisional; Region: PRK05111 205918001008 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 205918001009 metal binding site [ion binding]; metal-binding site 205918001010 putative dimer interface [polypeptide binding]; other site 205918001011 N-acetylglutamate synthase; Validated; Region: PRK05279 205918001012 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 205918001013 putative feedback inhibition sensing region; other site 205918001014 putative nucleotide binding site [chemical binding]; other site 205918001015 putative substrate binding site [chemical binding]; other site 205918001016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918001017 Coenzyme A binding pocket [chemical binding]; other site 205918001018 glutamate--cysteine ligase; Provisional; Region: PRK02107 205918001019 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 205918001020 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 205918001021 CoenzymeA binding site [chemical binding]; other site 205918001022 subunit interaction site [polypeptide binding]; other site 205918001023 PHB binding site; other site 205918001024 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 205918001025 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 205918001026 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 205918001027 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 205918001028 RNA binding site [nucleotide binding]; other site 205918001029 osmolarity response regulator; Provisional; Region: ompR; PRK09468 205918001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001031 active site 205918001032 phosphorylation site [posttranslational modification] 205918001033 intermolecular recognition site; other site 205918001034 dimerization interface [polypeptide binding]; other site 205918001035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918001036 DNA binding site [nucleotide binding] 205918001037 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 205918001038 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001039 dimerization interface [polypeptide binding]; other site 205918001040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918001041 ATP binding site [chemical binding]; other site 205918001042 Mg2+ binding site [ion binding]; other site 205918001043 G-X-G motif; other site 205918001044 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001045 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001046 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 205918001047 1 probable transmembrane helix predicted by TMHMM2.0 205918001048 BON domain; Region: BON; pfam04972 205918001049 BON domain; Region: BON; pfam04972 205918001050 BON domain; Region: BON; pfam04972 205918001051 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918001052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001053 active site 205918001054 phosphorylation site [posttranslational modification] 205918001055 intermolecular recognition site; other site 205918001056 dimerization interface [polypeptide binding]; other site 205918001057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918001058 Walker A motif; other site 205918001059 ATP binding site [chemical binding]; other site 205918001060 Walker B motif; other site 205918001061 arginine finger; other site 205918001062 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918001063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001064 dimerization interface [polypeptide binding]; other site 205918001065 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205918001066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918001067 putative active site [active] 205918001068 heme pocket [chemical binding]; other site 205918001069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918001070 dimer interface [polypeptide binding]; other site 205918001071 phosphorylation site [posttranslational modification] 205918001072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918001073 ATP binding site [chemical binding]; other site 205918001074 Mg2+ binding site [ion binding]; other site 205918001075 G-X-G motif; other site 205918001076 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001077 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001078 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 205918001079 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 205918001080 amidase catalytic site [active] 205918001081 Zn binding residues [ion binding]; other site 205918001082 substrate binding site [chemical binding]; other site 205918001083 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 205918001084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918001085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918001086 metal binding site [ion binding]; metal-binding site 205918001087 active site 205918001088 I-site; other site 205918001089 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205918001090 putative catalytic site [active] 205918001091 putative metal binding site [ion binding]; other site 205918001092 putative phosphate binding site [ion binding]; other site 205918001093 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 205918001094 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 205918001095 catalytic residues [active] 205918001096 hinge region; other site 205918001097 alpha helical domain; other site 205918001098 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 205918001099 G1 box; other site 205918001100 GTP/Mg2+ binding site [chemical binding]; other site 205918001101 Switch I region; other site 205918001102 G2 box; other site 205918001103 G3 box; other site 205918001104 Switch II region; other site 205918001105 G4 box; other site 205918001106 G5 box; other site 205918001107 DNA polymerase I; Provisional; Region: PRK05755 205918001108 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 205918001109 active site 205918001110 metal binding site 1 [ion binding]; metal-binding site 205918001111 putative 5' ssDNA interaction site; other site 205918001112 metal binding site 3; metal-binding site 205918001113 metal binding site 2 [ion binding]; metal-binding site 205918001114 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 205918001115 putative DNA binding site [nucleotide binding]; other site 205918001116 putative metal binding site [ion binding]; other site 205918001117 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 205918001118 active site 205918001119 catalytic site [active] 205918001120 substrate binding site [chemical binding]; other site 205918001121 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 205918001122 active site 205918001123 DNA binding site [nucleotide binding] 205918001124 catalytic site [active] 205918001125 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 205918001126 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 205918001127 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 205918001128 putative active site [active] 205918001129 putative substrate binding site [chemical binding]; other site 205918001130 ATP binding site [chemical binding]; other site 205918001131 putative transposase OrfB; Reviewed; Region: PHA02517 205918001132 HTH-like domain; Region: HTH_21; pfam13276 205918001133 Integrase core domain; Region: rve; pfam00665 205918001134 Integrase core domain; Region: rve_2; pfam13333 205918001135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918001136 Helix-turn-helix domain; Region: HTH_28; pfam13518 205918001137 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 205918001138 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 205918001139 metal binding site [ion binding]; metal-binding site 205918001140 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 205918001141 metal binding site 2 [ion binding]; metal-binding site 205918001142 putative DNA binding helix; other site 205918001143 metal binding site 1 [ion binding]; metal-binding site 205918001144 dimer interface [polypeptide binding]; other site 205918001145 structural Zn2+ binding site [ion binding]; other site 205918001146 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 205918001147 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 205918001148 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 205918001149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918001150 dimer interface [polypeptide binding]; other site 205918001151 putative PBP binding regions; other site 205918001152 ABC-ATPase subunit interface; other site 205918001153 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001154 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001155 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001156 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001157 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001158 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001159 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001160 hydroperoxidase II; Provisional; Region: katE; PRK11249 205918001161 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 205918001162 tetramer interface [polypeptide binding]; other site 205918001163 heme binding pocket [chemical binding]; other site 205918001164 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 205918001165 domain interactions; other site 205918001166 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 205918001167 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 205918001168 Walker A/P-loop; other site 205918001169 ATP binding site [chemical binding]; other site 205918001170 Q-loop/lid; other site 205918001171 ABC transporter signature motif; other site 205918001172 Walker B; other site 205918001173 D-loop; other site 205918001174 H-loop/switch region; other site 205918001175 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 205918001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001177 conserved gate region; other site 205918001178 ABC-ATPase subunit interface; other site 205918001179 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001180 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001181 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001182 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001183 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001184 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 205918001185 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 205918001186 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 205918001187 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205918001188 Cu(I) binding site [ion binding]; other site 205918001189 1 probable transmembrane helix predicted by TMHMM2.0 205918001190 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 205918001191 1 probable transmembrane helix predicted by TMHMM2.0 205918001192 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 205918001193 Sulfate transporter family; Region: Sulfate_transp; pfam00916 205918001194 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 205918001195 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001196 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001197 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001198 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001199 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001200 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001201 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001202 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001203 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001204 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001205 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 205918001206 active site clefts [active] 205918001207 zinc binding site [ion binding]; other site 205918001208 dimer interface [polypeptide binding]; other site 205918001209 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 205918001210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918001211 FeS/SAM binding site; other site 205918001212 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 205918001213 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 205918001214 conserved cys residue [active] 205918001215 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205918001216 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 205918001217 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001218 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001219 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001220 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001221 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001222 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 205918001223 dimer interface [polypeptide binding]; other site 205918001224 active site 205918001225 aspartate-rich active site metal binding site; other site 205918001226 allosteric magnesium binding site [ion binding]; other site 205918001227 Schiff base residues; other site 205918001228 polyphosphate kinase; Provisional; Region: PRK05443 205918001229 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 205918001230 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 205918001231 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918001232 putative active site [active] 205918001233 catalytic site [active] 205918001234 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 205918001235 putative domain interface [polypeptide binding]; other site 205918001236 putative active site [active] 205918001237 catalytic site [active] 205918001238 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 205918001239 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 205918001240 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918001241 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918001242 Walker A/P-loop; other site 205918001243 ATP binding site [chemical binding]; other site 205918001244 Q-loop/lid; other site 205918001245 ABC transporter signature motif; other site 205918001246 Walker B; other site 205918001247 D-loop; other site 205918001248 H-loop/switch region; other site 205918001249 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918001250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001251 dimer interface [polypeptide binding]; other site 205918001252 conserved gate region; other site 205918001253 putative PBP binding loops; other site 205918001254 ABC-ATPase subunit interface; other site 205918001255 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001256 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001257 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001258 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001259 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001260 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918001261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001262 dimer interface [polypeptide binding]; other site 205918001263 conserved gate region; other site 205918001264 putative PBP binding loops; other site 205918001265 ABC-ATPase subunit interface; other site 205918001266 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001267 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001268 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918001270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918001271 substrate binding pocket [chemical binding]; other site 205918001272 membrane-bound complex binding site; other site 205918001273 hinge residues; other site 205918001274 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918001275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918001276 DNA-binding site [nucleotide binding]; DNA binding site 205918001277 FCD domain; Region: FCD; pfam07729 205918001278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205918001279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205918001280 catalytic residues [active] 205918001281 transcription termination factor Rho; Provisional; Region: rho; PRK09376 205918001282 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 205918001283 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 205918001284 RNA binding site [nucleotide binding]; other site 205918001285 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 205918001286 multimer interface [polypeptide binding]; other site 205918001287 Walker A motif; other site 205918001288 ATP binding site [chemical binding]; other site 205918001289 Walker B motif; other site 205918001290 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 205918001291 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 205918001292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918001293 catalytic loop [active] 205918001294 iron binding site [ion binding]; other site 205918001295 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 205918001296 FAD binding pocket [chemical binding]; other site 205918001297 FAD binding motif [chemical binding]; other site 205918001298 phosphate binding motif [ion binding]; other site 205918001299 beta-alpha-beta structure motif; other site 205918001300 NAD binding pocket [chemical binding]; other site 205918001301 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 205918001302 putative active site pocket [active] 205918001303 dimerization interface [polypeptide binding]; other site 205918001304 putative catalytic residue [active] 205918001305 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 205918001306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001308 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001309 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001310 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001311 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001312 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001313 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001314 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001315 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001316 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001317 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001318 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001319 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001320 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918001321 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 205918001322 S-type Pyocin; Region: Pyocin_S; pfam06958 205918001323 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 205918001324 active site 205918001325 oxidoreductase, zinc-binding 205918001326 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918001327 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 205918001328 NAD(P) binding site [chemical binding]; other site 205918001329 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 205918001330 Uncharacterized conserved protein [Function unknown]; Region: COG2947 205918001331 1 probable transmembrane helix predicted by TMHMM2.0 205918001332 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 205918001333 Cell division protein ZapA; Region: ZapA; pfam05164 205918001334 TIGR02449 family protein; Region: TIGR02449 205918001335 hypothetical protein; Reviewed; Region: PRK02166 205918001336 proline aminopeptidase P II; Provisional; Region: PRK10879 205918001337 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 205918001338 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 205918001339 active site 205918001340 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 205918001341 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 205918001342 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 205918001343 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 205918001344 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 205918001345 Immunoglobulin domain; Region: Ig; cl11960 205918001346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918001347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918001348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001349 D-galactonate transporter; Region: 2A0114; TIGR00893 205918001350 putative substrate translocation pore; other site 205918001351 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001352 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001353 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001354 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001355 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001356 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001357 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001358 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001359 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001360 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001361 Serine hydrolase; Region: Ser_hydrolase; pfam06821 205918001362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918001363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918001364 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918001365 Walker A motif; other site 205918001366 ATP binding site [chemical binding]; other site 205918001367 Walker B motif; other site 205918001368 arginine finger; other site 205918001369 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 205918001370 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 205918001371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918001372 Secretory lipase; Region: LIP; pfam03583 205918001373 Methyltransferase domain; Region: Methyltransf_23; pfam13489 205918001374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001375 S-adenosylmethionine binding site [chemical binding]; other site 205918001376 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918001377 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 205918001378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 205918001379 acyl-activating enzyme (AAE) consensus motif; other site 205918001380 acyl-activating enzyme (AAE) consensus motif; other site 205918001381 AMP binding site [chemical binding]; other site 205918001382 active site 205918001383 CoA binding site [chemical binding]; other site 205918001384 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 205918001385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918001386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918001387 active site 205918001388 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 205918001389 H+ Antiporter protein; Region: 2A0121; TIGR00900 205918001390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001391 putative substrate translocation pore; other site 205918001392 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001393 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001394 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001395 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001396 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001397 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001398 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001399 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001400 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001401 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001402 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 205918001403 active site 205918001404 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 205918001405 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918001406 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918001407 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918001408 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918001409 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918001410 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 205918001411 Walker A/P-loop; other site 205918001412 ATP binding site [chemical binding]; other site 205918001413 Q-loop/lid; other site 205918001414 ABC transporter signature motif; other site 205918001415 Walker B; other site 205918001416 D-loop; other site 205918001417 H-loop/switch region; other site 205918001418 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205918001419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001420 dimer interface [polypeptide binding]; other site 205918001421 conserved gate region; other site 205918001422 putative PBP binding loops; other site 205918001423 ABC-ATPase subunit interface; other site 205918001424 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001425 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001426 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001427 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001428 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001429 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001430 NMT1-like family; Region: NMT1_2; pfam13379 205918001431 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918001432 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918001433 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001434 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001435 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918001436 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001437 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001438 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918001439 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918001440 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918001441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918001442 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918001443 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918001444 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001445 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001446 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001447 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001448 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001449 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001450 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001451 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001452 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001453 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001454 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001455 Methyltransferase domain; Region: Methyltransf_23; pfam13489 205918001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001457 S-adenosylmethionine binding site [chemical binding]; other site 205918001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001459 dimer interface [polypeptide binding]; other site 205918001460 conserved gate region; other site 205918001461 ABC-ATPase subunit interface; other site 205918001462 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001463 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001464 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001465 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001466 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001467 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 205918001468 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 205918001469 Walker A/P-loop; other site 205918001470 ATP binding site [chemical binding]; other site 205918001471 Q-loop/lid; other site 205918001472 ABC transporter signature motif; other site 205918001473 Walker B; other site 205918001474 D-loop; other site 205918001475 H-loop/switch region; other site 205918001476 NIL domain; Region: NIL; pfam09383 205918001477 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 205918001478 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918001479 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918001480 active site 205918001481 non-prolyl cis peptide bond; other site 205918001482 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 205918001483 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 205918001484 Flavin binding site [chemical binding]; other site 205918001485 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 205918001486 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918001487 active site 205918001488 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 205918001489 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918001490 Walker A/P-loop; other site 205918001491 ATP binding site [chemical binding]; other site 205918001492 Q-loop/lid; other site 205918001493 ABC transporter signature motif; other site 205918001494 Walker B; other site 205918001495 D-loop; other site 205918001496 H-loop/switch region; other site 205918001497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001498 dimer interface [polypeptide binding]; other site 205918001499 conserved gate region; other site 205918001500 putative PBP binding loops; other site 205918001501 ABC-ATPase subunit interface; other site 205918001502 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001503 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001504 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001505 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001506 cystine transporter subunit; Provisional; Region: PRK11260 205918001507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918001508 substrate binding pocket [chemical binding]; other site 205918001509 membrane-bound complex binding site; other site 205918001510 hinge residues; other site 205918001511 D-cysteine desulfhydrase; Validated; Region: PRK03910 205918001512 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205918001513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918001514 catalytic residue [active] 205918001515 serine O-acetyltransferase; Region: cysE; TIGR01172 205918001516 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 205918001517 trimer interface [polypeptide binding]; other site 205918001518 active site 205918001519 substrate binding site [chemical binding]; other site 205918001520 CoA binding site [chemical binding]; other site 205918001521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 205918001522 Anti-sigma-K factor rskA; Region: RskA; pfam10099 205918001523 1 probable transmembrane helix predicted by TMHMM2.0 205918001524 RNA polymerase sigma factor; Provisional; Region: PRK12537 205918001525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918001526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918001527 DNA binding residues [nucleotide binding] 205918001528 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 205918001529 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 205918001530 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001531 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001532 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001533 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001534 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001535 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001536 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001537 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001538 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001539 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001540 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001541 HutD; Region: HutD; pfam05962 205918001542 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 205918001543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918001544 DNA-binding site [nucleotide binding]; DNA binding site 205918001545 UTRA domain; Region: UTRA; pfam07702 205918001546 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 205918001547 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 205918001548 active site 205918001549 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 205918001550 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 205918001551 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 205918001552 fructose-1,6-bisphosphatase family protein; Region: PLN02628 205918001553 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 205918001554 AMP binding site [chemical binding]; other site 205918001555 metal binding site [ion binding]; metal-binding site 205918001556 active site 205918001557 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 205918001558 1 probable transmembrane helix predicted by TMHMM2.0 205918001559 membrane protein 205918001560 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001561 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001562 membrane protein 205918001563 1 probable transmembrane helix predicted by TMHMM2.0 205918001564 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 205918001565 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 205918001566 homodimer interface [polypeptide binding]; other site 205918001567 active site pocket [active] 205918001568 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 205918001569 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 205918001570 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 205918001571 putative active site [active] 205918001572 dimerization interface [polypeptide binding]; other site 205918001573 putative tRNAtyr binding site [nucleotide binding]; other site 205918001574 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 205918001575 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 205918001576 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 205918001577 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 205918001578 Ligand binding site; other site 205918001579 DXD motif; other site 205918001580 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001581 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001582 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001583 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001584 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001585 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001587 dimerization interface [polypeptide binding]; other site 205918001588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918001589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918001590 dimer interface [polypeptide binding]; other site 205918001591 putative CheW interface [polypeptide binding]; other site 205918001592 1 probable transmembrane helix predicted by TMHMM2.0 205918001593 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918001594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001595 dimerization interface [polypeptide binding]; other site 205918001596 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918001597 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918001598 dimer interface [polypeptide binding]; other site 205918001599 putative CheW interface [polypeptide binding]; other site 205918001600 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001601 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001602 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 205918001603 RNA methyltransferase, RsmE family; Region: TIGR00046 205918001604 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 205918001605 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001606 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001607 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001608 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001609 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001610 sec-independent translocase; Provisional; Region: tatB; PRK00404 205918001611 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 205918001612 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 205918001613 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 205918001614 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 205918001615 metal binding site [ion binding]; metal-binding site 205918001616 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 205918001617 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 205918001618 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 205918001619 1 probable transmembrane helix predicted by TMHMM2.0 205918001620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 205918001621 SCP-2 sterol transfer family; Region: SCP2; pfam02036 205918001622 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 205918001623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001624 S-adenosylmethionine binding site [chemical binding]; other site 205918001625 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 205918001626 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 205918001627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 205918001628 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 205918001629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918001630 Walker A motif; other site 205918001631 ATP binding site [chemical binding]; other site 205918001632 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 205918001633 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 205918001634 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 205918001635 active site 205918001636 HslU subunit interaction site [polypeptide binding]; other site 205918001637 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 205918001638 Sporulation related domain; Region: SPOR; pfam05036 205918001639 1 probable transmembrane helix predicted by TMHMM2.0 205918001640 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 205918001641 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 205918001642 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 205918001643 active site 205918001644 HIGH motif; other site 205918001645 KMSK motif region; other site 205918001646 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 205918001647 tRNA binding surface [nucleotide binding]; other site 205918001648 anticodon binding site; other site 205918001649 primosome assembly protein PriA; Validated; Region: PRK05580 205918001650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918001651 ATP binding site [chemical binding]; other site 205918001652 putative Mg++ binding site [ion binding]; other site 205918001653 helicase superfamily c-terminal domain; Region: HELICc; smart00490 205918001654 ATP-binding site [chemical binding]; other site 205918001655 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 205918001656 Staphylococcal nuclease homologues; Region: SNc; smart00318 205918001657 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 205918001658 Catalytic site; other site 205918001659 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 205918001660 Malic enzyme, N-terminal domain; Region: malic; pfam00390 205918001661 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 205918001662 putative NAD(P) binding site [chemical binding]; other site 205918001663 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 205918001664 Transglycosylase; Region: Transgly; pfam00912 205918001665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 205918001666 1 probable transmembrane helix predicted by TMHMM2.0 205918001667 Competence protein A; Region: Competence_A; pfam11104 205918001668 Cell division protein FtsA; Region: FtsA; cl17206 205918001669 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205918001670 nucleotide binding site [chemical binding]; other site 205918001671 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 205918001672 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 205918001673 1 probable transmembrane helix predicted by TMHMM2.0 205918001674 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 205918001675 1 probable transmembrane helix predicted by TMHMM2.0 205918001676 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 205918001677 Pilus assembly protein, PilP; Region: PilP; pfam04351 205918001678 AMIN domain; Region: AMIN; pfam11741 205918001679 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 205918001680 Secretin and TonB N terminus short domain; Region: STN; smart00965 205918001681 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918001682 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918001683 1 probable transmembrane helix predicted by TMHMM2.0 205918001684 shikimate kinase; Reviewed; Region: aroK; PRK00131 205918001685 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 205918001686 ADP binding site [chemical binding]; other site 205918001687 magnesium binding site [ion binding]; other site 205918001688 putative shikimate binding site; other site 205918001689 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 205918001690 active site 205918001691 dimer interface [polypeptide binding]; other site 205918001692 metal binding site [ion binding]; metal-binding site 205918001693 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 205918001694 Sporulation related domain; Region: SPOR; pfam05036 205918001695 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 205918001696 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 205918001697 active site 205918001698 dimer interface [polypeptide binding]; other site 205918001699 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 205918001700 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 205918001701 active site 205918001702 FMN binding site [chemical binding]; other site 205918001703 substrate binding site [chemical binding]; other site 205918001704 3Fe-4S cluster binding site [ion binding]; other site 205918001705 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 205918001706 domain interface; other site 205918001707 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 205918001708 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 205918001709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918001710 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 205918001711 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 205918001712 substrate binding site [chemical binding]; other site 205918001713 active site 205918001714 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 205918001715 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 205918001716 active site 205918001717 putative substrate binding pocket [chemical binding]; other site 205918001718 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 205918001719 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205918001720 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918001721 putative active site [active] 205918001722 fructuronate transporter; Provisional; Region: PRK10034; cl15264 205918001723 GntP family permease; Region: GntP_permease; pfam02447 205918001724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001725 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001726 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001727 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001728 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001729 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001730 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001731 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001732 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001733 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001734 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001735 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001736 TIGR02646 family protein; Region: TIGR02646 205918001737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918001738 AAA domain; Region: AAA_23; pfam13476 205918001739 Walker A/P-loop; other site 205918001740 ATP binding site [chemical binding]; other site 205918001741 Q-loop/lid; other site 205918001742 ABC transporter signature motif; other site 205918001743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001744 putative substrate translocation pore; other site 205918001745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001748 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001749 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001750 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001751 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001752 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001753 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001754 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001755 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001756 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001757 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 205918001758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918001759 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 205918001760 dimerization interface [polypeptide binding]; other site 205918001761 substrate binding pocket [chemical binding]; other site 205918001762 1 probable transmembrane helix predicted by TMHMM2.0 205918001763 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 205918001764 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918001765 dimer interface [polypeptide binding]; other site 205918001766 active site 205918001767 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 205918001768 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 205918001769 NAD(P) binding site [chemical binding]; other site 205918001770 homotetramer interface [polypeptide binding]; other site 205918001771 homodimer interface [polypeptide binding]; other site 205918001772 active site 205918001773 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 205918001774 putative active site 1 [active] 205918001775 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 205918001776 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918001777 dimer interface [polypeptide binding]; other site 205918001778 active site 205918001779 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 205918001780 Methyltransferase domain; Region: Methyltransf_23; pfam13489 205918001781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001782 S-adenosylmethionine binding site [chemical binding]; other site 205918001783 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 205918001784 Predicted exporter [General function prediction only]; Region: COG4258 205918001785 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001786 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001787 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001788 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001789 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001790 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001791 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001792 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001793 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001794 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001795 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 205918001796 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918001797 active site 205918001798 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 205918001799 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 205918001800 putative acyl-acceptor binding pocket; other site 205918001801 1 probable transmembrane helix predicted by TMHMM2.0 205918001802 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 205918001803 Ligand binding site; other site 205918001804 Putative Catalytic site; other site 205918001805 DXD motif; other site 205918001806 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 205918001807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 205918001808 AMP binding site [chemical binding]; other site 205918001809 active site 205918001810 acyl-activating enzyme (AAE) consensus motif; other site 205918001811 CoA binding site [chemical binding]; other site 205918001812 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 205918001813 active site 2 [active] 205918001814 dimer interface [polypeptide binding]; other site 205918001815 active site 1 [active] 205918001816 Predicted membrane protein [Function unknown]; Region: COG4648 205918001817 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001818 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001819 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001820 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001821 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001822 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001823 acyl carrier protein; Provisional; Region: PRK05350 205918001824 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918001825 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918001826 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918001827 putative acyl-acceptor binding pocket; other site 205918001828 1 probable transmembrane helix predicted by TMHMM2.0 205918001829 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 205918001830 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918001831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918001832 P-loop; other site 205918001833 Magnesium ion binding site [ion binding]; other site 205918001834 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918001835 Magnesium ion binding site [ion binding]; other site 205918001836 PAAR motif; Region: PAAR_motif; pfam05488 205918001837 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 205918001838 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 205918001839 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 205918001840 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 205918001841 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 205918001842 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 205918001843 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 205918001844 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 205918001845 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918001846 Malonate transporter MadL subunit; Region: MadL; cl04273 205918001847 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001848 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001849 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001850 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001851 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 205918001852 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001853 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001854 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001855 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001856 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001857 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001858 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001859 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918001861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918001862 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 205918001863 putative dimerization interface [polypeptide binding]; other site 205918001864 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 205918001865 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 205918001866 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001867 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001868 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001869 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001870 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001871 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001872 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001873 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 205918001874 RNA methyltransferase, RsmE family; Region: TIGR00046 205918001875 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 205918001876 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918001877 inhibitor-cofactor binding pocket; inhibition site 205918001878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918001879 catalytic residue [active] 205918001880 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 205918001881 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 205918001882 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001883 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001884 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001885 hypothetical protein; Provisional; Region: PRK03757 205918001886 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 205918001887 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918001888 ATP binding site [chemical binding]; other site 205918001889 Mg++ binding site [ion binding]; other site 205918001890 motif III; other site 205918001891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918001892 nucleotide binding region [chemical binding]; other site 205918001893 ATP-binding site [chemical binding]; other site 205918001894 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 205918001895 FAD binding site [chemical binding]; other site 205918001896 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 205918001897 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 205918001898 homotetramer interface [polypeptide binding]; other site 205918001899 ligand binding site [chemical binding]; other site 205918001900 catalytic site [active] 205918001901 NAD binding site [chemical binding]; other site 205918001902 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 205918001903 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 205918001904 fructuronate transporter; Provisional; Region: PRK10034; cl15264 205918001905 GntP family permease; Region: GntP_permease; pfam02447 205918001906 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001907 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001908 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001909 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001910 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001911 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001912 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001913 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001914 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001915 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001916 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001917 putative aldolase; Validated; Region: PRK08130 205918001918 intersubunit interface [polypeptide binding]; other site 205918001919 active site 205918001920 Zn2+ binding site [ion binding]; other site 205918001921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 205918001922 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 205918001923 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 205918001924 Flagellin N-methylase; Region: FliB; pfam03692 205918001925 aminotransferase; Validated; Region: PRK08175 205918001926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918001927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918001928 homodimer interface [polypeptide binding]; other site 205918001929 catalytic residue [active] 205918001930 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 205918001931 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 205918001932 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001933 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001934 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001935 HemN family oxidoreductase; Provisional; Region: PRK05660 205918001936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918001937 FeS/SAM binding site; other site 205918001938 HemN C-terminal domain; Region: HemN_C; pfam06969 205918001939 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 205918001940 active site 205918001941 dimerization interface [polypeptide binding]; other site 205918001942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001943 S-adenosylmethionine binding site [chemical binding]; other site 205918001944 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 205918001945 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 205918001946 YGGT family; Region: YGGT; pfam02325 205918001947 YGGT family; Region: YGGT; pfam02325 205918001948 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001949 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001950 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001951 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001952 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 205918001953 pyrroline-5-carboxylate reductase; Region: PLN02688 205918001954 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 205918001955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918001956 catalytic residue [active] 205918001957 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 205918001958 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 205918001959 Walker A motif; other site 205918001960 ATP binding site [chemical binding]; other site 205918001961 Walker B motif; other site 205918001962 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 205918001963 NlpC/P60 family; Region: NLPC_P60; pfam00877 205918001964 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 205918001965 TM2 domain; Region: TM2; cl00984 205918001966 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001967 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001968 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001969 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001970 dihydroorotase; Validated; Region: pyrC; PRK09357 205918001971 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918001972 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 205918001973 active site 205918001974 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 205918001975 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205918001976 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205918001977 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 205918001978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918001979 active site 205918001980 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 205918001981 hypothetical protein; Validated; Region: PRK00228 205918001982 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918001983 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918001984 1 probable transmembrane helix predicted by TMHMM2.0 205918001985 glutathione synthetase; Provisional; Region: PRK05246 205918001986 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 205918001987 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 205918001988 Response regulator receiver domain; Region: Response_reg; pfam00072 205918001989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001990 active site 205918001991 phosphorylation site [posttranslational modification] 205918001992 intermolecular recognition site; other site 205918001993 dimerization interface [polypeptide binding]; other site 205918001994 Response regulator receiver domain; Region: Response_reg; pfam00072 205918001995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001996 active site 205918001997 phosphorylation site [posttranslational modification] 205918001998 intermolecular recognition site; other site 205918001999 dimerization interface [polypeptide binding]; other site 205918002000 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918002001 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 205918002002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918002003 dimer interface [polypeptide binding]; other site 205918002004 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 205918002005 putative CheW interface [polypeptide binding]; other site 205918002006 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002007 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002008 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918002009 putative binding surface; other site 205918002010 active site 205918002011 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918002012 putative binding surface; other site 205918002013 active site 205918002014 Hpt domain; Region: Hpt; pfam01627 205918002015 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 205918002016 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918002017 putative binding surface; other site 205918002018 active site 205918002019 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918002020 putative binding surface; other site 205918002021 active site 205918002022 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 205918002023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918002024 ATP binding site [chemical binding]; other site 205918002025 Mg2+ binding site [ion binding]; other site 205918002026 G-X-G motif; other site 205918002027 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918002028 Response regulator receiver domain; Region: Response_reg; pfam00072 205918002029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918002030 active site 205918002031 phosphorylation site [posttranslational modification] 205918002032 intermolecular recognition site; other site 205918002033 dimerization interface [polypeptide binding]; other site 205918002034 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918002035 Uncharacterized conserved protein [Function unknown]; Region: COG0397 205918002036 hypothetical protein; Validated; Region: PRK00029 205918002037 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918002038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918002039 DNA-binding site [nucleotide binding]; DNA binding site 205918002040 FCD domain; Region: FCD; pfam07729 205918002041 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 205918002042 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002043 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002044 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002045 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002046 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002047 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002048 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002049 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002050 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002051 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002052 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002053 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 205918002054 putative active site [active] 205918002055 hypothetical protein; Provisional; Region: PRK05463 205918002056 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 205918002057 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 205918002058 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 205918002059 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 205918002060 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918002061 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 205918002062 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 205918002063 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 205918002064 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918002065 carboxyltransferase (CT) interaction site; other site 205918002066 biotinylation site [posttranslational modification]; other site 205918002067 hypothetical protein; Provisional; Region: PRK11281 205918002068 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 205918002069 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918002070 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002071 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002072 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002073 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002074 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002075 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002076 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002077 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002078 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002079 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002080 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002081 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002082 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 205918002083 TrkA-C domain; Region: TrkA_C; pfam02080 205918002084 Transporter associated domain; Region: CorC_HlyC; smart01091 205918002085 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002086 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002087 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002088 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002089 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002090 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002091 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002092 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002093 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002094 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002095 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002096 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002097 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 205918002098 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 205918002099 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 205918002100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918002101 active site 205918002102 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 205918002103 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 205918002104 Predicted transcriptional regulator [Transcription]; Region: COG3905 205918002105 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 205918002106 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 205918002107 Glutamate binding site [chemical binding]; other site 205918002108 NAD binding site [chemical binding]; other site 205918002109 catalytic residues [active] 205918002110 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 205918002111 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 205918002112 Na binding site [ion binding]; other site 205918002113 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002114 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002115 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002116 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002117 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002118 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002119 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002120 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002121 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002122 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002123 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002124 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002125 Alginate lyase; Region: Alginate_lyase2; pfam08787 205918002126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918002127 Response regulator receiver domain; Region: Response_reg; pfam00072 205918002128 active site 205918002129 phosphorylation site [posttranslational modification] 205918002130 intermolecular recognition site; other site 205918002131 dimerization interface [polypeptide binding]; other site 205918002132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918002133 PAS domain; Region: PAS_9; pfam13426 205918002134 putative active site [active] 205918002135 heme pocket [chemical binding]; other site 205918002136 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918002137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918002138 metal binding site [ion binding]; metal-binding site 205918002139 active site 205918002140 I-site; other site 205918002141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918002142 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 205918002143 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 205918002144 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918002145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918002146 Coenzyme A binding pocket [chemical binding]; other site 205918002147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918002148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918002149 substrate binding pocket [chemical binding]; other site 205918002150 membrane-bound complex binding site; other site 205918002151 hinge residues; other site 205918002152 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 205918002153 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 205918002154 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 205918002155 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002156 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002157 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002158 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002159 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002160 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002161 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002162 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002163 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002164 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002165 HI0933-like protein; Region: HI0933_like; pfam03486 205918002166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918002167 1 probable transmembrane helix predicted by TMHMM2.0 205918002168 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 205918002169 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918002170 ATP binding site [chemical binding]; other site 205918002171 Mg++ binding site [ion binding]; other site 205918002172 motif III; other site 205918002173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918002174 nucleotide binding region [chemical binding]; other site 205918002175 ATP-binding site [chemical binding]; other site 205918002176 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 205918002177 putative RNA binding site [nucleotide binding]; other site 205918002178 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 205918002179 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918002180 E3 interaction surface; other site 205918002181 lipoyl attachment site [posttranslational modification]; other site 205918002182 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918002183 E3 interaction surface; other site 205918002184 lipoyl attachment site [posttranslational modification]; other site 205918002185 e3 binding domain; Region: E3_binding; pfam02817 205918002186 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 205918002187 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 205918002188 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 205918002189 dimer interface [polypeptide binding]; other site 205918002190 TPP-binding site [chemical binding]; other site 205918002191 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 205918002192 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918002193 metal binding triad; other site 205918002194 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205918002195 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918002196 metal binding triad; other site 205918002197 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205918002198 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 205918002199 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 205918002200 putative active site [active] 205918002201 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 205918002202 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 205918002203 putative active site [active] 205918002204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918002205 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 205918002206 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 205918002207 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 205918002208 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 205918002209 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 205918002210 active site 205918002211 ATP binding site [chemical binding]; other site 205918002212 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 205918002213 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 205918002214 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 205918002215 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 205918002216 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 205918002217 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 205918002218 putative ADP-binding pocket [chemical binding]; other site 205918002219 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918002220 Mig-14; Region: Mig-14; pfam07395 205918002221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 205918002222 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 205918002223 1 probable transmembrane helix predicted by TMHMM2.0 205918002224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918002225 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 205918002226 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 205918002227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918002228 active site 205918002229 1 probable transmembrane helix predicted by TMHMM2.0 205918002230 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002231 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002232 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002233 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002234 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002235 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002236 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002237 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002238 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002239 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002240 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002241 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 205918002243 active site 205918002244 ATP binding site [chemical binding]; other site 205918002245 1 probable transmembrane helix predicted by TMHMM2.0 205918002246 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 205918002247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918002248 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 205918002249 Walker A/P-loop; other site 205918002250 ATP binding site [chemical binding]; other site 205918002251 Q-loop/lid; other site 205918002252 ABC transporter signature motif; other site 205918002253 Walker B; other site 205918002254 D-loop; other site 205918002255 H-loop/switch region; other site 205918002256 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002257 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002258 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002259 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002260 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002261 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 205918002262 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 205918002263 putative ribose interaction site [chemical binding]; other site 205918002264 putative ADP binding site [chemical binding]; other site 205918002265 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 205918002266 active site 205918002267 nucleotide binding site [chemical binding]; other site 205918002268 HIGH motif; other site 205918002269 KMSKS motif; other site 205918002270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918002271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918002272 active site 205918002273 catalytic tetrad [active] 205918002274 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 205918002275 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 205918002276 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002277 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002278 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002279 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 205918002280 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 205918002281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918002282 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918002283 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 205918002284 ThiC-associated domain; Region: ThiC-associated; pfam13667 205918002285 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 205918002286 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 205918002287 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918002288 Na binding site [ion binding]; other site 205918002289 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002290 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002291 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002292 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002293 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002294 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002295 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002296 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002297 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002298 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002299 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002300 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002301 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 205918002302 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 205918002303 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 205918002304 dimer interface [polypeptide binding]; other site 205918002305 ADP-ribose binding site [chemical binding]; other site 205918002306 active site 205918002307 nudix motif; other site 205918002308 metal binding site [ion binding]; metal-binding site 205918002309 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 205918002310 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 205918002311 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 205918002312 hexamer interface [polypeptide binding]; other site 205918002313 active site 205918002314 metal binding site [ion binding]; metal-binding site 205918002315 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 205918002316 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918002317 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 205918002318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918002319 ATP binding site [chemical binding]; other site 205918002320 Mg2+ binding site [ion binding]; other site 205918002321 G-X-G motif; other site 205918002322 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205918002323 anchoring element; other site 205918002324 dimer interface [polypeptide binding]; other site 205918002325 ATP binding site [chemical binding]; other site 205918002326 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 205918002327 active site 205918002328 metal binding site [ion binding]; metal-binding site 205918002329 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205918002330 SdiA-regulated; Region: SdiA-regulated; cd09971 205918002331 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 205918002332 catalytic motif [active] 205918002333 Catalytic residue [active] 205918002334 1 probable transmembrane helix predicted by TMHMM2.0 205918002335 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 205918002336 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 205918002337 CAP-like domain; other site 205918002338 active site 205918002339 primary dimer interface [polypeptide binding]; other site 205918002340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 205918002341 Protein of unknown function (DUF330); Region: DUF330; pfam03886 205918002342 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 205918002343 1 probable transmembrane helix predicted by TMHMM2.0 205918002344 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 205918002345 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 205918002346 phosphoserine phosphatase SerB; Region: serB; TIGR00338 205918002347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918002348 motif II; other site 205918002349 bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional; Region: PRK09629 205918002350 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 205918002351 active site residue [active] 205918002352 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 205918002353 active site residue [active] 205918002354 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 205918002355 HDOD domain; Region: HDOD; pfam08668 205918002356 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 205918002357 flagellar motor protein MotA; Validated; Region: PRK09110 205918002358 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002359 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002360 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002361 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002362 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 205918002363 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 205918002364 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918002365 ligand binding site [chemical binding]; other site 205918002366 1 probable transmembrane helix predicted by TMHMM2.0 205918002367 GTPase RsgA; Reviewed; Region: PRK12288 205918002368 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918002369 RNA binding site [nucleotide binding]; other site 205918002370 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 205918002371 GTPase/Zn-binding domain interface [polypeptide binding]; other site 205918002372 GTP/Mg2+ binding site [chemical binding]; other site 205918002373 G4 box; other site 205918002374 G5 box; other site 205918002375 G1 box; other site 205918002376 Switch I region; other site 205918002377 G2 box; other site 205918002378 G3 box; other site 205918002379 Switch II region; other site 205918002380 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 205918002381 catalytic site [active] 205918002382 putative active site [active] 205918002383 putative substrate binding site [chemical binding]; other site 205918002384 dimer interface [polypeptide binding]; other site 205918002385 Predicted membrane protein [Function unknown]; Region: COG2860 205918002386 UPF0126 domain; Region: UPF0126; pfam03458 205918002387 UPF0126 domain; Region: UPF0126; pfam03458 205918002388 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002389 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002390 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002391 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002392 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002393 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002394 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002395 epoxyqueuosine reductase; Region: TIGR00276 205918002396 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 205918002397 putative carbohydrate kinase; Provisional; Region: PRK10565 205918002398 Uncharacterized conserved protein [Function unknown]; Region: COG0062 205918002399 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 205918002400 putative substrate binding site [chemical binding]; other site 205918002401 putative ATP binding site [chemical binding]; other site 205918002402 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 205918002403 AMIN domain; Region: AMIN; pfam11741 205918002404 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 205918002405 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 205918002406 active site 205918002407 metal binding site [ion binding]; metal-binding site 205918002408 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918002409 1 probable transmembrane helix predicted by TMHMM2.0 205918002410 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 205918002411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918002412 ATP binding site [chemical binding]; other site 205918002413 Mg2+ binding site [ion binding]; other site 205918002414 G-X-G motif; other site 205918002415 Mitochondrial ribosomal subunit protein; Region: MRP-S28; pfam10213 205918002416 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 205918002417 ATP binding site [chemical binding]; other site 205918002418 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 205918002419 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 205918002420 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 205918002421 bacterial Hfq-like; Region: Hfq; cd01716 205918002422 hexamer interface [polypeptide binding]; other site 205918002423 Sm1 motif; other site 205918002424 RNA binding site [nucleotide binding]; other site 205918002425 Sm2 motif; other site 205918002426 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 205918002427 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 205918002428 HflX GTPase family; Region: HflX; cd01878 205918002429 G1 box; other site 205918002430 GTP/Mg2+ binding site [chemical binding]; other site 205918002431 Switch I region; other site 205918002432 G2 box; other site 205918002433 G3 box; other site 205918002434 Switch II region; other site 205918002435 G4 box; other site 205918002436 G5 box; other site 205918002437 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 205918002438 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 205918002439 HflK protein; Region: hflK; TIGR01933 205918002440 1 probable transmembrane helix predicted by TMHMM2.0 205918002441 HflC protein; Region: hflC; TIGR01932 205918002442 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 205918002443 1 probable transmembrane helix predicted by TMHMM2.0 205918002444 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 205918002445 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 205918002446 dimer interface [polypeptide binding]; other site 205918002447 motif 1; other site 205918002448 active site 205918002449 motif 2; other site 205918002450 motif 3; other site 205918002451 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 205918002452 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 205918002453 GDP-binding site [chemical binding]; other site 205918002454 ACT binding site; other site 205918002455 IMP binding site; other site 205918002456 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918002457 dimerization interface [polypeptide binding]; other site 205918002458 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918002459 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918002460 dimer interface [polypeptide binding]; other site 205918002461 putative CheW interface [polypeptide binding]; other site 205918002462 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002463 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002464 ribonuclease R; Region: RNase_R; TIGR02063 205918002465 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 205918002466 RNB domain; Region: RNB; pfam00773 205918002467 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 205918002468 RNA binding site [nucleotide binding]; other site 205918002469 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 205918002470 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 205918002471 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 205918002472 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 205918002473 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 205918002474 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002475 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002476 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002477 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002478 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002479 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002480 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002481 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 205918002482 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 205918002483 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 205918002484 replicative DNA helicase; Provisional; Region: PRK05748 205918002485 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205918002486 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205918002487 Walker A motif; other site 205918002488 ATP binding site [chemical binding]; other site 205918002489 Walker B motif; other site 205918002490 DNA binding loops [nucleotide binding] 205918002491 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918002492 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918002493 1 probable transmembrane helix predicted by TMHMM2.0 205918002494 hypothetical protein; Provisional; Region: PRK01254 205918002495 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 205918002496 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 205918002497 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205918002498 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205918002499 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 205918002500 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 205918002501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 205918002502 Uncharacterized conserved protein [Function unknown]; Region: COG2308 205918002503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 205918002504 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 205918002505 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205918002506 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205918002507 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 205918002508 azurin; Region: azurin; TIGR02695 205918002509 putative transposase OrfB; Reviewed; Region: PHA02517 205918002510 HTH-like domain; Region: HTH_21; pfam13276 205918002511 Integrase core domain; Region: rve; pfam00665 205918002512 Integrase core domain; Region: rve_2; pfam13333 205918002513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918002514 Helix-turn-helix domain; Region: HTH_28; pfam13518 205918002515 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 205918002516 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 205918002517 homodimer interface [polypeptide binding]; other site 205918002518 NAD binding pocket [chemical binding]; other site 205918002519 ATP binding pocket [chemical binding]; other site 205918002520 Mg binding site [ion binding]; other site 205918002521 active-site loop [active] 205918002522 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 205918002523 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 205918002524 active site 205918002525 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918002526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918002527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918002528 dimerization interface [polypeptide binding]; other site 205918002529 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 205918002530 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 205918002531 dimerization interface [polypeptide binding]; other site 205918002532 ligand binding site [chemical binding]; other site 205918002533 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918002534 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918002535 TM-ABC transporter signature motif; other site 205918002536 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002537 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002538 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002539 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002540 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002541 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002542 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002543 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 205918002544 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 205918002545 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918002546 TM-ABC transporter signature motif; other site 205918002547 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002548 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002549 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002550 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002551 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002552 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002553 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002554 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002555 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002556 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002557 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002558 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 205918002559 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 205918002560 Walker A/P-loop; other site 205918002561 ATP binding site [chemical binding]; other site 205918002562 Q-loop/lid; other site 205918002563 ABC transporter signature motif; other site 205918002564 Walker B; other site 205918002565 D-loop; other site 205918002566 H-loop/switch region; other site 205918002567 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 205918002568 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 205918002569 Walker A/P-loop; other site 205918002570 ATP binding site [chemical binding]; other site 205918002571 Q-loop/lid; other site 205918002572 ABC transporter signature motif; other site 205918002573 Walker B; other site 205918002574 D-loop; other site 205918002575 H-loop/switch region; other site 205918002576 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 205918002577 malonic semialdehyde reductase; Provisional; Region: PRK10538 205918002578 putative NAD(P) binding site [chemical binding]; other site 205918002579 homotetramer interface [polypeptide binding]; other site 205918002580 homodimer interface [polypeptide binding]; other site 205918002581 active site 205918002582 dimerization interface [polypeptide binding]; other site 205918002583 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 205918002584 putative active cleft [active] 205918002585 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 205918002586 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 205918002587 TPP-binding site; other site 205918002588 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205918002589 PYR/PP interface [polypeptide binding]; other site 205918002590 dimer interface [polypeptide binding]; other site 205918002591 TPP binding site [chemical binding]; other site 205918002592 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205918002593 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205918002594 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205918002595 substrate binding pocket [chemical binding]; other site 205918002596 chain length determination region; other site 205918002597 substrate-Mg2+ binding site; other site 205918002598 catalytic residues [active] 205918002599 aspartate-rich region 1; other site 205918002600 active site lid residues [active] 205918002601 aspartate-rich region 2; other site 205918002602 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 205918002603 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 205918002604 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918002605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918002606 catalytic residue [active] 205918002607 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 205918002608 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 205918002609 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 205918002610 putative S-transferase; Provisional; Region: PRK11752 205918002611 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 205918002612 C-terminal domain interface [polypeptide binding]; other site 205918002613 GSH binding site (G-site) [chemical binding]; other site 205918002614 dimer interface [polypeptide binding]; other site 205918002615 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 205918002616 dimer interface [polypeptide binding]; other site 205918002617 N-terminal domain interface [polypeptide binding]; other site 205918002618 active site 205918002619 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 205918002620 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 205918002621 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002622 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002623 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002624 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002625 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002626 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002627 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002628 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 205918002629 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 205918002630 Walker A/P-loop; other site 205918002631 ATP binding site [chemical binding]; other site 205918002632 Q-loop/lid; other site 205918002633 ABC transporter signature motif; other site 205918002634 Walker B; other site 205918002635 D-loop; other site 205918002636 H-loop/switch region; other site 205918002637 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 205918002638 Ligand binding site; other site 205918002639 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 205918002640 putative active site [active] 205918002641 catalytic site [active] 205918002642 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 205918002643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918002644 motif II; other site 205918002645 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 205918002646 Ligand binding site; other site 205918002647 Cupin domain; Region: Cupin_2; cl17218 205918002648 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 205918002649 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918002650 1 probable transmembrane helix predicted by TMHMM2.0 205918002651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918002652 non-specific DNA binding site [nucleotide binding]; other site 205918002653 salt bridge; other site 205918002654 sequence-specific DNA binding site [nucleotide binding]; other site 205918002655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918002656 non-specific DNA binding site [nucleotide binding]; other site 205918002657 salt bridge; other site 205918002658 sequence-specific DNA binding site [nucleotide binding]; other site 205918002659 Predicted transcriptional regulator [Transcription]; Region: COG2932 205918002660 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918002661 Catalytic site [active] 205918002662 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205918002663 dimer interface [polypeptide binding]; other site 205918002664 substrate binding site [chemical binding]; other site 205918002665 metal binding sites [ion binding]; metal-binding site 205918002666 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 205918002667 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205918002668 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205918002669 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002670 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002671 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002672 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002673 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002674 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 205918002675 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 205918002676 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 205918002677 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205918002678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918002679 NAD(P) binding site [chemical binding]; other site 205918002680 catalytic residues [active] 205918002681 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 205918002682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918002683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918002684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918002685 aromatic acid decarboxylase; Validated; Region: PRK05920 205918002686 Flavoprotein; Region: Flavoprotein; pfam02441 205918002687 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 205918002688 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 205918002689 NAD binding site [chemical binding]; other site 205918002690 active site 205918002691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 205918002692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 205918002693 Peptidase C13 family; Region: Peptidase_C13; cl02159 205918002694 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 205918002695 putative active site [active] 205918002696 putative catalytic site [active] 205918002697 LrgA family; Region: LrgA; cl00608 205918002698 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002699 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002700 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002701 LrgB-like family; Region: LrgB; pfam04172 205918002702 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002703 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002704 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002705 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002706 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002707 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002708 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 205918002709 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 205918002710 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 205918002711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918002712 S-adenosylmethionine binding site [chemical binding]; other site 205918002713 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 205918002714 homodimer interface [polypeptide binding]; other site 205918002715 chemical substrate binding site [chemical binding]; other site 205918002716 oligomer interface [polypeptide binding]; other site 205918002717 metal binding site [ion binding]; metal-binding site 205918002718 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918002719 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918002720 active site 2 [active] 205918002721 active site 1 [active] 205918002722 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 205918002723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918002724 NAD(P) binding site [chemical binding]; other site 205918002725 active site 205918002726 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 205918002727 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918002728 dimer interface [polypeptide binding]; other site 205918002729 active site 205918002730 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002731 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002732 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002733 Protein of unknown function (DUF726); Region: DUF726; pfam05277 205918002734 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 205918002735 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 205918002736 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002737 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002738 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002739 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002740 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002741 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002742 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002743 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002744 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002745 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002746 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 205918002747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918002748 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 205918002749 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 205918002750 ATP binding site [chemical binding]; other site 205918002751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918002752 Transposase; Region: HTH_Tnp_1; pfam01527 205918002753 putative transposase OrfB; Reviewed; Region: PHA02517 205918002754 HTH-like domain; Region: HTH_21; pfam13276 205918002755 Integrase core domain; Region: rve; pfam00665 205918002756 Integrase core domain; Region: rve_3; pfam13683 205918002757 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 205918002758 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 205918002759 DNA binding residues [nucleotide binding] 205918002760 dimer interface [polypeptide binding]; other site 205918002761 copper binding site [ion binding]; other site 205918002762 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 205918002763 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918002764 metal-binding site [ion binding] 205918002765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918002766 Soluble P-type ATPase [General function prediction only]; Region: COG4087 205918002767 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002768 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002769 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002770 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002771 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002772 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002773 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002774 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002775 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918002776 metal-binding site [ion binding] 205918002777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918002778 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 205918002779 putative substrate translocation pore; other site 205918002780 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002781 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002782 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002783 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002784 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002785 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002786 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002787 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002788 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002789 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002790 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002791 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002792 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 205918002793 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 205918002794 putative NAD(P) binding site [chemical binding]; other site 205918002795 dimer interface [polypeptide binding]; other site 205918002796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918002797 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918002798 putative effector binding pocket; other site 205918002799 dimerization interface [polypeptide binding]; other site 205918002800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918002801 putative DNA binding site [nucleotide binding]; other site 205918002802 putative Zn2+ binding site [ion binding]; other site 205918002803 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 205918002804 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 205918002805 active site 205918002806 purine riboside binding site [chemical binding]; other site 205918002807 oxidase reductase; Provisional; Region: PTZ00273 205918002808 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 205918002809 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 205918002810 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 205918002811 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 205918002812 putative ligand binding site [chemical binding]; other site 205918002813 1 probable transmembrane helix predicted by TMHMM2.0 205918002814 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 205918002815 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918002816 Walker A/P-loop; other site 205918002817 ATP binding site [chemical binding]; other site 205918002818 Q-loop/lid; other site 205918002819 ABC transporter signature motif; other site 205918002820 Walker B; other site 205918002821 D-loop; other site 205918002822 H-loop/switch region; other site 205918002823 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 205918002824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918002825 ABC-ATPase subunit interface; other site 205918002826 dimer interface [polypeptide binding]; other site 205918002827 putative PBP binding regions; other site 205918002828 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002829 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002830 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002831 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002832 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002833 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002834 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002835 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002836 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002837 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 205918002838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918002839 putative PBP binding regions; other site 205918002840 ABC-ATPase subunit interface; other site 205918002841 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002842 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002843 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002844 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002845 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002846 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002847 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002848 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002849 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002850 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 205918002851 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 205918002852 siderophore binding site; other site 205918002853 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 205918002854 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 205918002855 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002856 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002857 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002858 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002859 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002860 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002861 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002862 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002863 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002864 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 205918002865 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 205918002866 active site 205918002867 putative substrate binding pocket [chemical binding]; other site 205918002868 short chain dehydrogenase; Provisional; Region: PRK08177 205918002869 C factor cell-cell signaling protein; Provisional; Region: PRK09009 205918002870 NAD(P) binding site [chemical binding]; other site 205918002871 active site 205918002872 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918002873 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918002874 TM-ABC transporter signature motif; other site 205918002875 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002876 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002877 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002878 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002879 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002880 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002881 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002882 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002883 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002884 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918002885 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918002886 TM-ABC transporter signature motif; other site 205918002887 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002888 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002889 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002890 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002891 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002892 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002893 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002894 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002895 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002896 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 205918002897 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918002898 Walker A/P-loop; other site 205918002899 ATP binding site [chemical binding]; other site 205918002900 Q-loop/lid; other site 205918002901 ABC transporter signature motif; other site 205918002902 Walker B; other site 205918002903 D-loop; other site 205918002904 H-loop/switch region; other site 205918002905 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918002906 Uncharacterized conserved protein [Function unknown]; Region: COG1739 205918002907 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 205918002908 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 205918002909 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 205918002910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918002911 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 205918002912 xanthine permease; Region: pbuX; TIGR03173 205918002913 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 205918002914 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002915 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002916 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002917 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002918 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002919 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002920 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002921 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002922 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002923 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002924 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002925 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918002927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918002928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918002929 dimerization interface [polypeptide binding]; other site 205918002930 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 205918002931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918002932 inhibitor-cofactor binding pocket; inhibition site 205918002933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918002934 catalytic residue [active] 205918002935 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 205918002936 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 205918002937 tetrameric interface [polypeptide binding]; other site 205918002938 NAD binding site [chemical binding]; other site 205918002939 catalytic residues [active] 205918002940 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 205918002941 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 205918002942 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 205918002943 Family description; Region: UvrD_C_2; pfam13538 205918002944 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 205918002945 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 205918002946 AAA domain; Region: AAA_30; pfam13604 205918002947 Family description; Region: UvrD_C_2; pfam13538 205918002948 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 205918002949 nudix motif; other site 205918002950 1 probable transmembrane helix predicted by TMHMM2.0 205918002951 Uncharacterized conserved protein [Function unknown]; Region: COG4104 205918002952 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002953 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002954 GAD-like domain; Region: GAD-like; pfam08887 205918002955 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 205918002956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918002957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918002958 LysR substrate binding domain; Region: LysR_substrate; pfam03466 205918002959 dimerization interface [polypeptide binding]; other site 205918002960 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 205918002961 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 205918002962 tetrameric interface [polypeptide binding]; other site 205918002963 NAD binding site [chemical binding]; other site 205918002964 catalytic residues [active] 205918002965 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 205918002966 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 205918002967 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 205918002968 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 205918002969 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 205918002970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918002971 dimer interface [polypeptide binding]; other site 205918002972 conserved gate region; other site 205918002973 putative PBP binding loops; other site 205918002974 ABC-ATPase subunit interface; other site 205918002975 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002976 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002977 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002978 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002979 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002980 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002981 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 205918002982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918002983 dimer interface [polypeptide binding]; other site 205918002984 conserved gate region; other site 205918002985 putative PBP binding loops; other site 205918002986 ABC-ATPase subunit interface; other site 205918002987 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002988 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002989 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002990 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002991 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002992 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002993 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 205918002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918002995 Walker A/P-loop; other site 205918002996 ATP binding site [chemical binding]; other site 205918002997 Q-loop/lid; other site 205918002998 ABC transporter signature motif; other site 205918002999 Walker B; other site 205918003000 D-loop; other site 205918003001 H-loop/switch region; other site 205918003002 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 205918003003 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918003004 substrate binding pocket [chemical binding]; other site 205918003005 membrane-bound complex binding site; other site 205918003006 hinge residues; other site 205918003007 selenophosphate synthetase; Provisional; Region: PRK00943 205918003008 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 205918003009 dimerization interface [polypeptide binding]; other site 205918003010 putative ATP binding site [chemical binding]; other site 205918003011 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 205918003012 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 205918003013 active site residue [active] 205918003014 membrane protein 205918003015 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003016 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003017 membrane protein 205918003018 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205918003019 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205918003020 substrate binding pocket [chemical binding]; other site 205918003021 chain length determination region; other site 205918003022 substrate-Mg2+ binding site; other site 205918003023 catalytic residues [active] 205918003024 aspartate-rich region 1; other site 205918003025 active site lid residues [active] 205918003026 aspartate-rich region 2; other site 205918003027 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 205918003028 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 205918003029 GTPase CgtA; Reviewed; Region: obgE; PRK12298 205918003030 GTP1/OBG; Region: GTP1_OBG; pfam01018 205918003031 Obg GTPase; Region: Obg; cd01898 205918003032 G1 box; other site 205918003033 GTP/Mg2+ binding site [chemical binding]; other site 205918003034 Switch I region; other site 205918003035 G2 box; other site 205918003036 G3 box; other site 205918003037 Switch II region; other site 205918003038 G4 box; other site 205918003039 G5 box; other site 205918003040 gamma-glutamyl kinase; Provisional; Region: PRK05429 205918003041 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 205918003042 nucleotide binding site [chemical binding]; other site 205918003043 homotetrameric interface [polypeptide binding]; other site 205918003044 putative phosphate binding site [ion binding]; other site 205918003045 putative allosteric binding site; other site 205918003046 PUA domain; Region: PUA; pfam01472 205918003047 CreA protein; Region: CreA; pfam05981 205918003048 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205918003049 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003050 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003051 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003052 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003053 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003054 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003055 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003056 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003057 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003058 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 205918003060 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 205918003061 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 205918003062 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003063 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003064 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003065 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003066 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003067 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003068 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003069 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003070 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003071 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003072 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003073 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003074 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918003075 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 205918003076 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 205918003077 active site 205918003078 Riboflavin kinase; Region: Flavokinase; pfam01687 205918003079 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 205918003080 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918003081 active site 205918003082 HIGH motif; other site 205918003083 nucleotide binding site [chemical binding]; other site 205918003084 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205918003085 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205918003086 active site 205918003087 KMSKS motif; other site 205918003088 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 205918003089 tRNA binding surface [nucleotide binding]; other site 205918003090 anticodon binding site; other site 205918003091 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 205918003092 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 205918003093 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003094 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003095 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003096 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003097 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003098 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 205918003099 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918003100 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 205918003101 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 205918003102 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 205918003103 Type II transport protein GspH; Region: GspH; pfam12019 205918003104 1 probable transmembrane helix predicted by TMHMM2.0 205918003105 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918003106 Type II transport protein GspH; Region: GspH; pfam12019 205918003107 1 probable transmembrane helix predicted by TMHMM2.0 205918003108 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 205918003109 1 probable transmembrane helix predicted by TMHMM2.0 205918003110 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 205918003111 1 probable transmembrane helix predicted by TMHMM2.0 205918003112 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 205918003113 PilX N-terminal; Region: PilX_N; pfam14341 205918003114 1 probable transmembrane helix predicted by TMHMM2.0 205918003115 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 205918003116 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 205918003117 1 probable transmembrane helix predicted by TMHMM2.0 205918003118 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 205918003119 1 probable transmembrane helix predicted by TMHMM2.0 205918003120 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 205918003121 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918003122 1 probable transmembrane helix predicted by TMHMM2.0 205918003123 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918003124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003125 active site 205918003126 phosphorylation site [posttranslational modification] 205918003127 intermolecular recognition site; other site 205918003128 dimerization interface [polypeptide binding]; other site 205918003129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003130 Walker A motif; other site 205918003131 ATP binding site [chemical binding]; other site 205918003132 Walker B motif; other site 205918003133 arginine finger; other site 205918003134 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918003135 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918003136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918003137 putative active site [active] 205918003138 heme pocket [chemical binding]; other site 205918003139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918003140 dimer interface [polypeptide binding]; other site 205918003141 phosphorylation site [posttranslational modification] 205918003142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918003143 ATP binding site [chemical binding]; other site 205918003144 Mg2+ binding site [ion binding]; other site 205918003145 G-X-G motif; other site 205918003146 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003147 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003148 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003149 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003150 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003151 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 205918003152 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 205918003153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918003154 RNA binding surface [nucleotide binding]; other site 205918003155 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205918003156 active site 205918003157 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 205918003158 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 205918003159 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 205918003160 Clp amino terminal domain; Region: Clp_N; pfam02861 205918003161 Clp amino terminal domain; Region: Clp_N; pfam02861 205918003162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003163 Walker A motif; other site 205918003164 ATP binding site [chemical binding]; other site 205918003165 Walker B motif; other site 205918003166 arginine finger; other site 205918003167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003168 Walker A motif; other site 205918003169 ATP binding site [chemical binding]; other site 205918003170 Walker B motif; other site 205918003171 arginine finger; other site 205918003172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205918003173 Integrase 205918003174 Integrase 205918003175 Protein of unknown function DUF1528 205918003176 conserved hypothetical protein 205918003177 Putative helicase; Region: TraI_2; pfam07514 205918003178 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 205918003179 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918003180 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918003181 Catalytic site [active] 205918003182 Y-family of DNA polymerases; Region: PolY; cl12025 205918003183 active site 205918003184 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 205918003185 Phage integrase, N-terminal SAM-like 205918003186 Phage integrase 205918003187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918003188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918003189 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918003190 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 205918003191 substrate binding site [chemical binding]; other site 205918003192 oxyanion hole (OAH) forming residues; other site 205918003193 trimer interface [polypeptide binding]; other site 205918003194 hypothetical protein 205918003195 Transposase IS66 205918003196 hypothetical protein 205918003197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 205918003198 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 205918003199 Transposase IS3/IS911 205918003200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918003201 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918003202 putative substrate translocation pore; other site 205918003203 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003204 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003205 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003206 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003207 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003208 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003209 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003210 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003211 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003212 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003213 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003214 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003215 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003216 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003217 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918003218 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 205918003219 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 205918003220 acyl-activating enzyme (AAE) consensus motif; other site 205918003221 acyl-activating enzyme (AAE) consensus motif; other site 205918003222 putative AMP binding site [chemical binding]; other site 205918003223 putative active site [active] 205918003224 putative CoA binding site [chemical binding]; other site 205918003225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205918003226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918003227 S-adenosylmethionine binding site [chemical binding]; other site 205918003228 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 205918003229 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 205918003230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 205918003231 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 205918003232 active site 205918003233 MEKHLA domain; Region: MEKHLA; pfam08670 205918003234 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 205918003235 active site 205918003236 ribulose/triose binding site [chemical binding]; other site 205918003237 phosphate binding site [ion binding]; other site 205918003238 substrate (anthranilate) binding pocket [chemical binding]; other site 205918003239 product (indole) binding pocket [chemical binding]; other site 205918003240 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918003241 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918003242 DNA binding site [nucleotide binding] 205918003243 domain linker motif; other site 205918003244 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 205918003245 putative dimerization interface [polypeptide binding]; other site 205918003246 putative ligand binding site [chemical binding]; other site 205918003247 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 205918003248 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 205918003249 substrate binding [chemical binding]; other site 205918003250 active site 205918003251 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 205918003252 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918003253 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 205918003254 Walker A/P-loop; other site 205918003255 ATP binding site [chemical binding]; other site 205918003256 Q-loop/lid; other site 205918003257 ABC transporter signature motif; other site 205918003258 Walker B; other site 205918003259 D-loop; other site 205918003260 H-loop/switch region; other site 205918003261 TOBE domain; Region: TOBE_2; pfam08402 205918003262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918003263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918003264 dimer interface [polypeptide binding]; other site 205918003265 conserved gate region; other site 205918003266 putative PBP binding loops; other site 205918003267 ABC-ATPase subunit interface; other site 205918003268 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003269 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003270 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003271 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003272 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003273 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003274 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918003276 dimer interface [polypeptide binding]; other site 205918003277 conserved gate region; other site 205918003278 putative PBP binding loops; other site 205918003279 ABC-ATPase subunit interface; other site 205918003280 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003281 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003282 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003283 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003284 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003285 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003286 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918003287 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205918003288 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 205918003289 trimer interface; other site 205918003290 sugar binding site [chemical binding]; other site 205918003291 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918003292 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 205918003293 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003294 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003295 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003296 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 205918003297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918003298 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 205918003299 dimerization interface [polypeptide binding]; other site 205918003300 substrate binding pocket [chemical binding]; other site 205918003301 Predicted membrane protein [Function unknown]; Region: COG2323 205918003302 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003303 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003304 1 probable transmembrane helix predicted by TMHMM2.0 205918003305 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 205918003306 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 205918003307 metal binding site [ion binding]; metal-binding site 205918003308 dimer interface [polypeptide binding]; other site 205918003309 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 205918003310 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 205918003311 active site 205918003312 substrate binding pocket [chemical binding]; other site 205918003313 homodimer interaction site [polypeptide binding]; other site 205918003314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918003315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918003316 TM-ABC transporter signature motif; other site 205918003317 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003318 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003319 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003320 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003321 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003322 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003323 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003324 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003325 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003326 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918003327 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205918003328 Walker A/P-loop; other site 205918003329 ATP binding site [chemical binding]; other site 205918003330 Q-loop/lid; other site 205918003331 ABC transporter signature motif; other site 205918003332 Walker B; other site 205918003333 D-loop; other site 205918003334 H-loop/switch region; other site 205918003335 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 205918003336 ligand binding site [chemical binding]; other site 205918003337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 205918003338 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918003339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918003340 DNA binding site [nucleotide binding] 205918003341 domain linker motif; other site 205918003342 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 205918003343 putative dimerization interface [polypeptide binding]; other site 205918003344 putative ligand binding site [chemical binding]; other site 205918003345 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205918003346 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 205918003347 nudix motif; other site 205918003348 similar to Pseudomonas syringae tomato virulence protein HopAI1; this region is disrupted by a frameshift between 887086 and 887089 205918003349 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 205918003350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003351 active site 205918003352 phosphorylation site [posttranslational modification] 205918003353 intermolecular recognition site; other site 205918003354 dimerization interface [polypeptide binding]; other site 205918003355 CheB methylesterase; Region: CheB_methylest; pfam01339 205918003356 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13498 205918003357 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918003358 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 205918003359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918003360 S-adenosylmethionine binding site [chemical binding]; other site 205918003361 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 205918003362 putative CheA interaction surface; other site 205918003363 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003365 dimerization interface [polypeptide binding]; other site 205918003366 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003368 dimer interface [polypeptide binding]; other site 205918003369 putative CheW interface [polypeptide binding]; other site 205918003370 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003371 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003372 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918003373 putative binding surface; other site 205918003374 active site 205918003375 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 205918003376 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 205918003377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918003378 ATP binding site [chemical binding]; other site 205918003379 Mg2+ binding site [ion binding]; other site 205918003380 G-X-G motif; other site 205918003381 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 205918003382 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918003383 anti sigma factor interaction site; other site 205918003384 regulatory phosphorylation site [posttranslational modification]; other site 205918003385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003386 Response regulator receiver domain; Region: Response_reg; pfam00072 205918003387 active site 205918003388 phosphorylation site [posttranslational modification] 205918003389 intermolecular recognition site; other site 205918003390 dimerization interface [polypeptide binding]; other site 205918003391 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003392 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003393 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 205918003394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918003395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918003396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 205918003397 MOSC domain; Region: MOSC; pfam03473 205918003398 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 205918003399 DNA gyrase inhibitor; Reviewed; Region: PRK00418 205918003400 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205918003401 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 205918003402 CoA-binding site [chemical binding]; other site 205918003403 ATP-binding [chemical binding]; other site 205918003404 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 205918003405 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 205918003406 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 205918003407 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003408 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003409 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003410 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003411 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003412 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003413 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 205918003414 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918003415 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918003416 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003417 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003418 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003419 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 205918003420 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918003421 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 205918003422 Walker A motif; other site 205918003423 ATP binding site [chemical binding]; other site 205918003424 Walker B motif; other site 205918003425 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 205918003426 Pilin (bacterial filament); Region: Pilin; pfam00114 205918003427 1 probable transmembrane helix predicted by TMHMM2.0 205918003428 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 205918003429 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003430 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003431 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 205918003432 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003433 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 205918003434 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 205918003435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918003436 active site 205918003437 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 205918003438 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 205918003439 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 205918003440 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 205918003441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 205918003442 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003443 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003444 putative metal binding site [ion binding]; other site 205918003445 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003446 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003447 putative metal binding site [ion binding]; other site 205918003448 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 205918003449 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003450 putative metal binding site [ion binding]; other site 205918003451 tellurite resistance protein terB; Region: terB; cd07176 205918003452 putative metal binding site [ion binding]; other site 205918003453 Integral membrane protein TerC family; Region: TerC; cl10468 205918003454 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003455 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003456 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003457 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003458 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003459 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003460 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003461 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003462 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003463 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003464 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003465 putative metal binding site [ion binding]; other site 205918003466 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003467 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003468 putative metal binding site [ion binding]; other site 205918003469 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 205918003470 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 205918003471 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 205918003472 dimerization interface [polypeptide binding]; other site 205918003473 active site 205918003474 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 205918003475 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 205918003476 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 205918003477 amidase catalytic site [active] 205918003478 Zn binding residues [ion binding]; other site 205918003479 substrate binding site [chemical binding]; other site 205918003480 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 205918003481 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003482 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003483 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003484 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003485 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003486 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205918003487 active site 205918003488 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 205918003489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918003490 DNA binding site [nucleotide binding] 205918003491 domain linker motif; other site 205918003492 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 205918003493 dimerization interface [polypeptide binding]; other site 205918003494 ligand binding site [chemical binding]; other site 205918003495 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 205918003496 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 205918003497 active site 205918003498 phosphorylation site [posttranslational modification] 205918003499 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 205918003500 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 205918003501 dimerization domain swap beta strand [polypeptide binding]; other site 205918003502 regulatory protein interface [polypeptide binding]; other site 205918003503 active site 205918003504 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 205918003505 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 205918003506 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 205918003507 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 205918003508 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 205918003509 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 205918003510 putative substrate binding site [chemical binding]; other site 205918003511 putative ATP binding site [chemical binding]; other site 205918003512 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 205918003513 active site 205918003514 P-loop; other site 205918003515 phosphorylation site [posttranslational modification] 205918003516 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 205918003517 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 205918003518 active site 205918003519 P-loop; other site 205918003520 phosphorylation site [posttranslational modification] 205918003521 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 205918003522 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003523 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003524 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003525 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003526 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003527 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003528 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003529 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003530 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003531 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 205918003532 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918003533 dimer interface [polypeptide binding]; other site 205918003534 active site 205918003535 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 205918003536 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 205918003537 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 205918003538 active site 205918003539 dimer interface [polypeptide binding]; other site 205918003540 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 205918003541 dimer interface [polypeptide binding]; other site 205918003542 active site 205918003543 Pantoate-beta-alanine ligase; Region: PanC; cd00560 205918003544 pantoate--beta-alanine ligase; Region: panC; TIGR00018 205918003545 active site 205918003546 ATP-binding site [chemical binding]; other site 205918003547 pantoate-binding site; other site 205918003548 HXXH motif; other site 205918003549 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 205918003550 oligomerization interface [polypeptide binding]; other site 205918003551 active site 205918003552 metal binding site [ion binding]; metal-binding site 205918003553 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205918003554 catalytic center binding site [active] 205918003555 ATP binding site [chemical binding]; other site 205918003556 poly(A) polymerase; Region: pcnB; TIGR01942 205918003557 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205918003558 active site 205918003559 NTP binding site [chemical binding]; other site 205918003560 metal binding triad [ion binding]; metal-binding site 205918003561 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205918003562 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 205918003563 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918003564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003565 active site 205918003566 phosphorylation site [posttranslational modification] 205918003567 intermolecular recognition site; other site 205918003568 dimerization interface [polypeptide binding]; other site 205918003569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003570 Walker A motif; other site 205918003571 ATP binding site [chemical binding]; other site 205918003572 Walker B motif; other site 205918003573 arginine finger; other site 205918003574 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 205918003575 Na binding site [ion binding]; other site 205918003576 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918003577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918003578 putative active site [active] 205918003579 heme pocket [chemical binding]; other site 205918003580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918003581 dimer interface [polypeptide binding]; other site 205918003582 phosphorylation site [posttranslational modification] 205918003583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918003584 ATP binding site [chemical binding]; other site 205918003585 Mg2+ binding site [ion binding]; other site 205918003586 G-X-G motif; other site 205918003587 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003588 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003589 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003590 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003591 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003592 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003593 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003594 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003595 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003596 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003597 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003598 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003599 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003600 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003601 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003602 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003603 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 205918003604 active site 205918003605 HIGH motif; other site 205918003606 nucleotide binding site [chemical binding]; other site 205918003607 KMSKS motif; other site 205918003608 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 205918003609 hypothetical protein; Provisional; Region: PRK08960 205918003610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918003612 homodimer interface [polypeptide binding]; other site 205918003613 catalytic residue [active] 205918003614 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 205918003615 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 205918003616 iron-sulfur cluster [ion binding]; other site 205918003617 [2Fe-2S] cluster binding site [ion binding]; other site 205918003618 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 205918003619 intersubunit interface [polypeptide binding]; other site 205918003620 active site 205918003621 catalytic residue [active] 205918003622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 205918003623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 205918003624 AAA domain; Region: AAA_33; pfam13671 205918003625 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205918003626 ATP-binding site [chemical binding]; other site 205918003627 Gluconate-6-phosphate binding site [chemical binding]; other site 205918003628 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 205918003629 Transglycosylase; Region: Transgly; pfam00912 205918003630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 205918003631 1 probable transmembrane helix predicted by TMHMM2.0 205918003632 Tetratricopeptide repeat; Region: TPR_16; pfam13432 205918003633 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 205918003634 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918003635 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 205918003636 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205918003637 PYR/PP interface [polypeptide binding]; other site 205918003638 dimer interface [polypeptide binding]; other site 205918003639 TPP binding site [chemical binding]; other site 205918003640 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 205918003641 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 205918003642 TPP-binding site [chemical binding]; other site 205918003643 dimer interface [polypeptide binding]; other site 205918003644 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 205918003645 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 205918003646 putative valine binding site [chemical binding]; other site 205918003647 dimer interface [polypeptide binding]; other site 205918003648 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 205918003649 ketol-acid reductoisomerase; Provisional; Region: PRK05479 205918003650 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 205918003651 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 205918003652 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 205918003653 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 205918003654 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003655 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003656 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003657 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003658 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003659 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003660 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003661 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003662 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 205918003663 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 205918003664 Moco binding site; other site 205918003665 metal coordination site [ion binding]; other site 205918003666 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 205918003667 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003668 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003669 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003670 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003671 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003672 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003673 Right handed beta helix region; Region: Beta_helix; pfam13229 205918003674 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 205918003675 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 205918003676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918003677 Coenzyme A binding pocket [chemical binding]; other site 205918003678 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 205918003679 active site clefts [active] 205918003680 zinc binding site [ion binding]; other site 205918003681 dimer interface [polypeptide binding]; other site 205918003682 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003684 dimerization interface [polypeptide binding]; other site 205918003685 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003687 dimer interface [polypeptide binding]; other site 205918003688 putative CheW interface [polypeptide binding]; other site 205918003689 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003690 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 205918003692 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 205918003693 Zn2+ binding site [ion binding]; other site 205918003694 Mg2+ binding site [ion binding]; other site 205918003695 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205918003696 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003697 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003698 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003699 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003700 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003701 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003702 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003703 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003704 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003705 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003706 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 205918003707 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 205918003708 PhnA protein; Region: PhnA; pfam03831 205918003709 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 205918003710 putative arabinose transporter; Provisional; Region: PRK03545 205918003711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918003712 putative substrate translocation pore; other site 205918003713 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003714 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003715 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003716 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003717 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003718 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003719 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003720 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003721 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003722 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003723 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003725 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 205918003726 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 205918003727 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003728 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003729 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003730 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003731 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003732 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003733 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918003734 metal binding site [ion binding]; metal-binding site 205918003735 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 205918003736 putative active site [active] 205918003737 putative metal binding site [ion binding]; other site 205918003738 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003739 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 205918003740 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918003741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003742 dimerization interface [polypeptide binding]; other site 205918003743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003744 dimer interface [polypeptide binding]; other site 205918003745 putative CheW interface [polypeptide binding]; other site 205918003746 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003747 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918003749 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918003750 Coenzyme A binding pocket [chemical binding]; other site 205918003751 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918003752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918003753 metal binding site [ion binding]; metal-binding site 205918003754 active site 205918003755 I-site; other site 205918003756 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003757 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003758 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003759 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003760 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003761 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003762 PAS domain; Region: PAS_9; pfam13426 205918003763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918003764 putative active site [active] 205918003765 heme pocket [chemical binding]; other site 205918003766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918003767 PAS domain; Region: PAS_9; pfam13426 205918003768 putative active site [active] 205918003769 heme pocket [chemical binding]; other site 205918003770 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003771 dimer interface [polypeptide binding]; other site 205918003772 putative CheW interface [polypeptide binding]; other site 205918003773 PhoD-like phosphatase; Region: PhoD; pfam09423 205918003774 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 205918003775 putative active site [active] 205918003776 putative metal binding site [ion binding]; other site 205918003777 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918003778 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205918003779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918003780 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918003781 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 205918003782 1 probable transmembrane helix predicted by TMHMM2.0 205918003783 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918003784 1 probable transmembrane helix predicted by TMHMM2.0 205918003785 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918003786 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918003787 N-terminal plug; other site 205918003788 ligand-binding site [chemical binding]; other site 205918003789 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918003790 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003791 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003792 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003793 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 205918003794 PLD-like domain; Region: PLDc_2; pfam13091 205918003795 putative active site [active] 205918003796 putative catalytic site [active] 205918003797 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 205918003798 PLD-like domain; Region: PLDc_2; pfam13091 205918003799 putative active site [active] 205918003800 putative catalytic site [active] 205918003801 putative acetyltransferase YhhY; Provisional; Region: PRK10140 205918003802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918003803 Coenzyme A binding pocket [chemical binding]; other site 205918003804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918003805 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 205918003806 MltA specific insert domain; Region: MltA; smart00925 205918003807 3D domain; Region: 3D; pfam06725 205918003808 S-type Pyocin; Region: Pyocin_S; pfam06958 205918003809 RES domain; Region: RES; cl02411 205918003810 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 205918003811 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 205918003812 Response regulator receiver domain; Region: Response_reg; pfam00072 205918003813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003814 active site 205918003815 phosphorylation site [posttranslational modification] 205918003816 intermolecular recognition site; other site 205918003817 dimerization interface [polypeptide binding]; other site 205918003818 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 205918003819 PAS fold; Region: PAS_4; pfam08448 205918003820 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 205918003821 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 205918003822 hinge; other site 205918003823 active site 205918003824 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 205918003825 toxin ChpB; Provisional; Region: PRK09812 205918003826 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 205918003827 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 205918003828 1 probable transmembrane helix predicted by TMHMM2.0 205918003829 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 205918003830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918003831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918003832 DNA binding residues [nucleotide binding] 205918003833 1 probable transmembrane helix predicted by TMHMM2.0 205918003834 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 205918003835 oligomeric interface; other site 205918003836 putative active site [active] 205918003837 homodimer interface [polypeptide binding]; other site 205918003838 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 205918003839 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 205918003840 active site 205918003841 catalytic residues [active] 205918003842 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 205918003843 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003844 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003845 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003846 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003847 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003848 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003849 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003850 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003851 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003852 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003853 DctM-like transporters; Region: DctM; pfam06808 205918003854 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 205918003855 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003856 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003857 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003858 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003859 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003860 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003861 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003862 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003863 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003864 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003865 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003866 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 205918003867 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003868 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003869 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003870 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003871 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 205918003872 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 205918003873 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918003874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918003875 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918003876 extended (e) SDRs; Region: SDR_e; cd08946 205918003877 NAD(P) binding site [chemical binding]; other site 205918003878 active site 205918003879 active site 205918003880 substrate binding site [chemical binding]; other site 205918003881 outer membrane porin, OprD family; Region: OprD; pfam03573 205918003882 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918003883 classical (c) SDRs; Region: SDR_c; cd05233 205918003884 NAD(P) binding site [chemical binding]; other site 205918003885 active site 205918003886 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003887 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918003888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003889 dimerization interface [polypeptide binding]; other site 205918003890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003891 dimer interface [polypeptide binding]; other site 205918003892 putative CheW interface [polypeptide binding]; other site 205918003893 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003894 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003895 Cache domain; Region: Cache_1; pfam02743 205918003896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003897 dimerization interface [polypeptide binding]; other site 205918003898 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003900 dimer interface [polypeptide binding]; other site 205918003901 putative CheW interface [polypeptide binding]; other site 205918003902 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003903 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003904 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 205918003905 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 205918003906 active site 205918003907 substrate binding site [chemical binding]; other site 205918003908 FMN binding site [chemical binding]; other site 205918003909 putative catalytic residues [active] 205918003910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918003911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918003912 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 205918003913 putative dimerization interface [polypeptide binding]; other site 205918003914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918003915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918003916 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 205918003917 EamA-like transporter family; Region: EamA; pfam00892 205918003918 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003919 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003920 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003921 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003922 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003923 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003924 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003925 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003926 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003927 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003928 DnaJ domain; Region: DnaJ; pfam00226 205918003929 HSP70 interaction site [polypeptide binding]; other site 205918003930 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918003931 HAMP domain; Region: HAMP; pfam00672 205918003932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003933 dimer interface [polypeptide binding]; other site 205918003934 putative CheW interface [polypeptide binding]; other site 205918003935 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003936 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918003938 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 205918003939 putative ADP-binding pocket [chemical binding]; other site 205918003940 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 205918003941 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 205918003942 NADP-binding site; other site 205918003943 homotetramer interface [polypeptide binding]; other site 205918003944 substrate binding site [chemical binding]; other site 205918003945 homodimer interface [polypeptide binding]; other site 205918003946 active site 205918003947 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 205918003948 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 205918003949 NADP-binding site; other site 205918003950 homotetramer interface [polypeptide binding]; other site 205918003951 substrate binding site [chemical binding]; other site 205918003952 homodimer interface [polypeptide binding]; other site 205918003953 active site 205918003954 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 205918003955 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 205918003956 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003957 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003958 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003959 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003960 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003961 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 205918003963 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 205918003964 Walker A/P-loop; other site 205918003965 ATP binding site [chemical binding]; other site 205918003966 Q-loop/lid; other site 205918003967 ABC transporter signature motif; other site 205918003968 Walker B; other site 205918003969 D-loop; other site 205918003970 H-loop/switch region; other site 205918003971 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 205918003972 putative carbohydrate binding site [chemical binding]; other site 205918003973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205918003974 Methyltransferase domain; Region: Methyltransf_23; pfam13489 205918003975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918003976 S-adenosylmethionine binding site [chemical binding]; other site 205918003977 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918003978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918003979 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918003980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918003981 Predicted membrane protein [Function unknown]; Region: COG2246 205918003982 GtrA-like protein; Region: GtrA; pfam04138 205918003983 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003984 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003985 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003986 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003987 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 205918003988 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 205918003989 Ligand binding site; other site 205918003990 Putative Catalytic site; other site 205918003991 DXD motif; other site 205918003992 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003993 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003994 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003995 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003996 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003997 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003998 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003999 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004000 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004001 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004002 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004003 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 205918004004 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 205918004005 substrate binding site; other site 205918004006 tetramer interface; other site 205918004007 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 205918004008 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 205918004009 NADP binding site [chemical binding]; other site 205918004010 active site 205918004011 putative substrate binding site [chemical binding]; other site 205918004012 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 205918004013 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 205918004014 NAD binding site [chemical binding]; other site 205918004015 substrate binding site [chemical binding]; other site 205918004016 homodimer interface [polypeptide binding]; other site 205918004017 active site 205918004018 Methyltransferase domain; Region: Methyltransf_24; pfam13578 205918004019 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 205918004020 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 205918004021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918004022 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918004023 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 205918004024 Probable Catalytic site; other site 205918004025 metal-binding site 205918004026 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918004027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918004028 active site 205918004029 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918004030 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918004031 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918004032 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 205918004033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918004034 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 205918004035 Walker A/P-loop; other site 205918004036 ATP binding site [chemical binding]; other site 205918004037 Q-loop/lid; other site 205918004038 ABC transporter signature motif; other site 205918004039 Walker B; other site 205918004040 D-loop; other site 205918004041 H-loop/switch region; other site 205918004042 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004043 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004044 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004045 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004046 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004047 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205918004048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918004049 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918004050 1 probable transmembrane helix predicted by TMHMM2.0 205918004051 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918004052 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918004053 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 205918004054 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 205918004055 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 205918004056 Substrate binding site; other site 205918004057 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 205918004058 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 205918004059 Transcriptional regulator, AcrR family 205918004060 transcriptional regulatory protein 205918004061 GTP-binding protein YchF; Reviewed; Region: PRK09601 205918004062 YchF GTPase; Region: YchF; cd01900 205918004063 G1 box; other site 205918004064 GTP/Mg2+ binding site [chemical binding]; other site 205918004065 Switch I region; other site 205918004066 G2 box; other site 205918004067 Switch II region; other site 205918004068 G3 box; other site 205918004069 G4 box; other site 205918004070 G5 box; other site 205918004071 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 205918004072 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 205918004073 putative active site [active] 205918004074 catalytic residue [active] 205918004075 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 205918004076 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 205918004077 5S rRNA interface [nucleotide binding]; other site 205918004078 CTC domain interface [polypeptide binding]; other site 205918004079 L16 interface [polypeptide binding]; other site 205918004080 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 205918004081 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 205918004082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918004083 active site 205918004084 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 205918004085 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 205918004086 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 205918004087 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 205918004088 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 205918004089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918004090 TPR motif; other site 205918004091 binding surface 205918004092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918004093 binding surface 205918004094 TPR motif; other site 205918004095 TPR repeat; Region: TPR_11; pfam13414 205918004096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918004097 binding surface 205918004098 TPR motif; other site 205918004099 TPR repeat; Region: TPR_11; pfam13414 205918004100 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 205918004101 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 205918004102 tRNA; other site 205918004103 putative tRNA binding site [nucleotide binding]; other site 205918004104 putative NADP binding site [chemical binding]; other site 205918004105 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 205918004106 peptide chain release factor 1; Validated; Region: prfA; PRK00591 205918004107 This domain is found in peptide chain release factors; Region: PCRF; smart00937 205918004108 RF-1 domain; Region: RF-1; pfam00472 205918004109 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 205918004110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918004111 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 205918004112 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 205918004113 ATP binding site [chemical binding]; other site 205918004114 substrate interface [chemical binding]; other site 205918004115 1 probable transmembrane helix predicted by TMHMM2.0 205918004116 glutamate racemase; Provisional; Region: PRK00865 205918004117 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 205918004118 Flagellin N-methylase; Region: FliB; pfam03692 205918004119 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 205918004120 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004121 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004122 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004123 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004124 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004125 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 205918004126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918004127 S-adenosylmethionine binding site [chemical binding]; other site 205918004128 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 205918004129 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 205918004130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918004131 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 205918004132 classical (c) SDRs; Region: SDR_c; cd05233 205918004133 NAD(P) binding site [chemical binding]; other site 205918004134 active site 205918004135 1 probable transmembrane helix predicted by TMHMM2.0 205918004136 SnoaL-like domain; Region: SnoaL_2; pfam12680 205918004137 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 205918004138 DNA photolyase; Region: DNA_photolyase; pfam00875 205918004139 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 205918004140 DNA binding residues [nucleotide binding] 205918004141 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205918004142 B12 binding domain; Region: B12-binding_2; pfam02607 205918004143 Protein of unknown function (DUF523); Region: DUF523; pfam04463 205918004144 Uncharacterized conserved protein [Function unknown]; Region: COG3272 205918004145 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 205918004146 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 205918004147 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 205918004148 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 205918004149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004150 NAD(P) binding site [chemical binding]; other site 205918004151 active site 205918004152 ferrochelatase; Reviewed; Region: hemH; PRK00035 205918004153 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 205918004154 C-terminal domain interface [polypeptide binding]; other site 205918004155 active site 205918004156 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 205918004157 active site 205918004158 N-terminal domain interface [polypeptide binding]; other site 205918004159 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 205918004160 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004161 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004162 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004163 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004164 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004165 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004166 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004167 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004168 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004169 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004170 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004171 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918004173 active site 205918004174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918004175 active site 205918004176 1 probable transmembrane helix predicted by TMHMM2.0 205918004177 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 205918004178 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004180 putative PBP binding loops; other site 205918004181 dimer interface [polypeptide binding]; other site 205918004182 ABC-ATPase subunit interface; other site 205918004183 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004184 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004185 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004186 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004187 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004188 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918004190 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918004191 substrate binding pocket [chemical binding]; other site 205918004192 membrane-bound complex binding site; other site 205918004193 hinge residues; other site 205918004194 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 205918004195 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 205918004196 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 205918004197 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 205918004198 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 205918004199 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918004200 putative acyl-acceptor binding pocket; other site 205918004201 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 205918004202 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 205918004203 Uncharacterized conserved protein [Function unknown]; Region: COG2135 205918004204 Peptidase family M48; Region: Peptidase_M48; pfam01435 205918004205 1 probable transmembrane helix predicted by TMHMM2.0 205918004206 Predicted membrane protein [Function unknown]; Region: COG2119 205918004207 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 205918004208 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 205918004209 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004210 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004211 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004212 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004213 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004214 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 205918004215 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 205918004216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918004217 S-adenosylmethionine binding site [chemical binding]; other site 205918004218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918004219 Transposase; Region: HTH_Tnp_1; pfam01527 205918004220 putative transposase OrfB; Reviewed; Region: PHA02517 205918004221 HTH-like domain; Region: HTH_21; pfam13276 205918004222 Integrase core domain; Region: rve; pfam00665 205918004223 Integrase core domain; Region: rve_3; pfam13683 205918004224 LysE type translocator; Region: LysE; cl00565 205918004225 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004226 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004227 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004228 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004229 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004230 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 205918004231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 205918004232 acyl-activating enzyme (AAE) consensus motif; other site 205918004233 AMP binding site [chemical binding]; other site 205918004234 active site 205918004235 CoA binding site [chemical binding]; other site 205918004236 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 205918004237 1 probable transmembrane helix predicted by TMHMM2.0 205918004238 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 205918004239 1 probable transmembrane helix predicted by TMHMM2.0 205918004240 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 205918004241 AAA ATPase domain; Region: AAA_16; pfam13191 205918004242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918004243 DNA binding residues [nucleotide binding] 205918004244 dimerization interface [polypeptide binding]; other site 205918004245 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 205918004246 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 205918004247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205918004248 Zn2+ binding site [ion binding]; other site 205918004249 Mg2+ binding site [ion binding]; other site 205918004250 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 205918004251 pyrimidine utilization protein D; Region: RutD; TIGR03611 205918004252 TAP-like protein; Region: Abhydrolase_4; pfam08386 205918004253 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918004254 homotrimer interaction site [polypeptide binding]; other site 205918004255 putative active site [active] 205918004256 Isochorismatase family; Region: Isochorismatase; pfam00857 205918004257 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918004258 catalytic triad [active] 205918004259 conserved cis-peptide bond; other site 205918004260 pyrimidine utilization protein A; Region: RutA; TIGR03612 205918004261 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918004262 active site 205918004263 dimer interface [polypeptide binding]; other site 205918004264 non-prolyl cis peptide bond; other site 205918004265 insertion regions; other site 205918004266 1 probable transmembrane helix predicted by TMHMM2.0 205918004267 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 205918004268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918004269 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 205918004270 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 205918004271 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 205918004272 putative ligand binding site [chemical binding]; other site 205918004273 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 205918004274 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918004275 Walker A/P-loop; other site 205918004276 ATP binding site [chemical binding]; other site 205918004277 Q-loop/lid; other site 205918004278 ABC transporter signature motif; other site 205918004279 Walker B; other site 205918004280 D-loop; other site 205918004281 H-loop/switch region; other site 205918004282 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918004283 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918004284 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918004285 TM-ABC transporter signature motif; other site 205918004286 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004287 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004288 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004289 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004290 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004291 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004292 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004293 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004294 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004295 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918004297 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918004298 TM-ABC transporter signature motif; other site 205918004299 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004300 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004301 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004302 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004303 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004304 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004305 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004306 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004307 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004308 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918004309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918004310 ligand binding site [chemical binding]; other site 205918004311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918004312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 205918004313 putative acyl-acceptor binding pocket; other site 205918004314 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004315 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004316 phosphate acetyltransferase; Reviewed; Region: PRK05632 205918004317 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918004318 DRTGG domain; Region: DRTGG; pfam07085 205918004319 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 205918004320 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 205918004321 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 205918004322 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918004323 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 205918004324 catalytic residues [active] 205918004325 dimer interface [polypeptide binding]; other site 205918004326 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918004327 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 205918004328 putative active site [active] 205918004329 putative FMN binding site [chemical binding]; other site 205918004330 putative substrate binding site [chemical binding]; other site 205918004331 putative catalytic residue [active] 205918004332 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 205918004333 putative sulfate transport protein CysZ; Validated; Region: PRK04949 205918004334 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004335 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004336 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004337 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004338 thioredoxin reductase; Provisional; Region: PRK10262 205918004339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918004340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918004341 HopJ type III effector protein; Region: HopJ; pfam08888 205918004342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 205918004343 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 205918004344 homooctamer interface [polypeptide binding]; other site 205918004345 active site 205918004346 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 205918004347 homodecamer interface [polypeptide binding]; other site 205918004348 GTP cyclohydrolase I; Provisional; Region: PLN03044 205918004349 active site 205918004350 putative catalytic site residues [active] 205918004351 zinc binding site [ion binding]; other site 205918004352 GTP-CH-I/GFRP interaction surface; other site 205918004353 dihydromonapterin reductase; Provisional; Region: PRK06483 205918004354 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 205918004355 NADP binding site [chemical binding]; other site 205918004356 substrate binding pocket [chemical binding]; other site 205918004357 active site 205918004358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 205918004359 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004360 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004361 flavodoxin; Provisional; Region: PRK05723 205918004362 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 205918004363 homodimer interface [polypeptide binding]; other site 205918004364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918004365 NAD binding site [chemical binding]; other site 205918004366 active site 205918004367 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 205918004368 Tetratricopeptide repeat; Region: TPR_9; pfam13371 205918004369 hypothetical protein; Provisional; Region: PRK09936 205918004370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918004371 TPR motif; other site 205918004372 binding surface 205918004373 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 205918004374 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 205918004375 active site 205918004376 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 205918004377 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918004378 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004379 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004380 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004381 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004382 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 205918004383 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004384 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004385 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 205918004386 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 205918004387 active site 205918004388 homodimer interface [polypeptide binding]; other site 205918004389 YebG protein; Region: YebG; pfam07130 205918004390 Predicted membrane protein [Function unknown]; Region: COG3223 205918004391 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004392 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004393 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004394 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004395 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 205918004396 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 205918004397 30S subunit binding site; other site 205918004398 Secretin and TonB N terminus short domain; Region: STN; smart00965 205918004399 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 205918004400 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918004401 N-terminal plug; other site 205918004402 ligand-binding site [chemical binding]; other site 205918004403 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918004404 FecR protein; Region: FecR; pfam04773 205918004405 RNA polymerase sigma factor; Provisional; Region: PRK12528 205918004406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918004407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918004408 DNA binding residues [nucleotide binding] 205918004409 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 205918004410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918004411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918004412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918004413 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 205918004414 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004415 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004416 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004417 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004418 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004419 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004420 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004421 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004422 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004423 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004424 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 205918004425 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 205918004426 dimerization interface [polypeptide binding]; other site 205918004427 ligand binding site [chemical binding]; other site 205918004428 NADP binding site [chemical binding]; other site 205918004429 catalytic site [active] 205918004430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918004431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918004432 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918004433 putative effector binding pocket; other site 205918004434 dimerization interface [polypeptide binding]; other site 205918004435 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918004436 1 probable transmembrane helix predicted by TMHMM2.0 205918004437 Fusaric acid resistance protein family; Region: FUSC; pfam04632 205918004438 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 205918004439 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004440 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004441 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004442 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004443 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004444 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004445 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004446 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004447 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004448 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004449 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 205918004450 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004451 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004452 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 205918004453 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918004454 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918004455 1 probable transmembrane helix predicted by TMHMM2.0 205918004456 short chain dehydrogenase; Provisional; Region: PRK05693 205918004457 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 205918004458 NADP binding site [chemical binding]; other site 205918004459 active site 205918004460 steroid binding site; other site 205918004461 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004462 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004463 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918004464 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918004465 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 205918004466 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 205918004467 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 205918004468 Substrate binding site; other site 205918004469 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 205918004470 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 205918004471 1 probable transmembrane helix predicted by TMHMM2.0 205918004472 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 205918004473 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004474 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004475 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004476 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004477 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004478 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004479 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004480 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004481 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004482 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 205918004483 active site 205918004484 Right handed beta helix region; Region: Beta_helix; pfam13229 205918004485 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 205918004486 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918004487 Sel1 repeat; Region: Sel1; cl02723 205918004488 PilZ domain; Region: PilZ; pfam07238 205918004489 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918004490 1 probable transmembrane helix predicted by TMHMM2.0 205918004491 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918004492 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 205918004493 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004494 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004495 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004496 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004497 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 205918004498 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 205918004499 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 205918004500 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 205918004501 hypothetical protein; Validated; Region: PRK02101 205918004502 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 205918004503 NodB motif; other site 205918004504 active site 205918004505 catalytic site [active] 205918004506 metal binding site [ion binding]; metal-binding site 205918004507 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 205918004508 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 205918004509 putative active site [active] 205918004510 PhoH-like protein; Region: PhoH; pfam02562 205918004511 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 205918004512 trimer interface [polypeptide binding]; other site 205918004513 dimer interface [polypeptide binding]; other site 205918004514 putative active site [active] 205918004515 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 205918004516 MoaE interaction surface [polypeptide binding]; other site 205918004517 MoeB interaction surface [polypeptide binding]; other site 205918004518 thiocarboxylated glycine; other site 205918004519 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 205918004520 MoaE homodimer interface [polypeptide binding]; other site 205918004521 MoaD interaction [polypeptide binding]; other site 205918004522 active site residues [active] 205918004523 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 205918004524 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918004525 ATP binding site [chemical binding]; other site 205918004526 Mg++ binding site [ion binding]; other site 205918004527 motif III; other site 205918004528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918004529 nucleotide binding region [chemical binding]; other site 205918004530 ATP-binding site [chemical binding]; other site 205918004531 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 205918004532 putative hydrolase; Provisional; Region: PRK11460 205918004533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918004534 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205918004535 substrate binding pocket [chemical binding]; other site 205918004536 membrane-bound complex binding site; other site 205918004537 hinge residues; other site 205918004538 1 probable transmembrane helix predicted by TMHMM2.0 205918004539 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 205918004540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004541 conserved gate region; other site 205918004542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004543 dimer interface [polypeptide binding]; other site 205918004544 conserved gate region; other site 205918004545 putative PBP binding loops; other site 205918004546 ABC-ATPase subunit interface; other site 205918004547 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004548 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004549 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004550 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004551 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004552 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004553 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004554 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004555 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918004556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004557 dimer interface [polypeptide binding]; other site 205918004558 conserved gate region; other site 205918004559 putative PBP binding loops; other site 205918004560 ABC-ATPase subunit interface; other site 205918004561 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004562 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004563 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004564 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004565 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004566 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004567 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004568 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004569 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918004570 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918004571 Walker A/P-loop; other site 205918004572 ATP binding site [chemical binding]; other site 205918004573 Q-loop/lid; other site 205918004574 ABC transporter signature motif; other site 205918004575 Walker B; other site 205918004576 D-loop; other site 205918004577 H-loop/switch region; other site 205918004578 cyanate transporter; Region: CynX; TIGR00896 205918004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918004580 putative substrate translocation pore; other site 205918004581 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004582 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004583 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004584 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004585 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004586 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004587 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004588 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004589 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004590 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004591 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004592 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004593 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 205918004594 NmrA-like family; Region: NmrA; pfam05368 205918004595 NAD(P) binding site [chemical binding]; other site 205918004596 active site lysine 205918004597 Predicted transcriptional regulators [Transcription]; Region: COG1733 205918004598 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 205918004599 SnoaL-like domain; Region: SnoaL_2; pfam12680 205918004600 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 205918004601 GIY-YIG motif/motif A; other site 205918004602 putative active site [active] 205918004603 putative metal binding site [ion binding]; other site 205918004604 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918004605 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 205918004606 C-terminal domain interface [polypeptide binding]; other site 205918004607 GSH binding site (G-site) [chemical binding]; other site 205918004608 dimer interface [polypeptide binding]; other site 205918004609 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 205918004610 substrate binding pocket (H-site) [chemical binding]; other site 205918004611 N-terminal domain interface [polypeptide binding]; other site 205918004612 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 205918004613 catalytic residues [active] 205918004614 Nucleoid-associated protein [General function prediction only]; Region: COG3081 205918004615 nucleoid-associated protein NdpA; Validated; Region: PRK00378 205918004616 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918004617 IHF dimer interface [polypeptide binding]; other site 205918004618 IHF - DNA interface [nucleotide binding]; other site 205918004619 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 205918004620 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 205918004621 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 205918004622 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 205918004623 HIGH motif; other site 205918004624 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205918004625 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 205918004626 active site 205918004627 KMSKS motif; other site 205918004628 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 205918004629 tRNA binding surface [nucleotide binding]; other site 205918004630 anticodon binding site; other site 205918004631 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 205918004632 hypothetical protein 205918004633 hypothetical protein 205918004634 DNA polymerase III subunit chi; Validated; Region: PRK05728 205918004635 multifunctional aminopeptidase A; Provisional; Region: PRK00913 205918004636 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 205918004637 interface (dimer of trimers) [polypeptide binding]; other site 205918004638 Substrate-binding/catalytic site; other site 205918004639 Zn-binding sites [ion binding]; other site 205918004640 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 205918004641 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 205918004642 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004643 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004644 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004645 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004646 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004647 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004648 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 205918004649 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 205918004650 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004651 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004652 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004653 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004654 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004655 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004656 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205918004657 DNA-binding site [nucleotide binding]; DNA binding site 205918004658 RNA-binding motif; other site 205918004659 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 205918004660 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918004661 glycine dehydrogenase; Provisional; Region: PRK05367 205918004662 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 205918004663 tetramer interface [polypeptide binding]; other site 205918004664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918004665 catalytic residue [active] 205918004666 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 205918004667 tetramer interface [polypeptide binding]; other site 205918004668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918004669 catalytic residue [active] 205918004670 glycine cleavage system protein H; Provisional; Region: PRK13380 205918004671 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 205918004672 lipoyl attachment site [posttranslational modification]; other site 205918004673 response regulator PleD; Reviewed; Region: pleD; PRK09581 205918004674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004675 active site 205918004676 phosphorylation site [posttranslational modification] 205918004677 intermolecular recognition site; other site 205918004678 dimerization interface [polypeptide binding]; other site 205918004679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004680 putative active site [active] 205918004681 heme pocket [chemical binding]; other site 205918004682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004683 metal binding site [ion binding]; metal-binding site 205918004684 active site 205918004685 I-site; other site 205918004686 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918004687 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918004688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004689 active site 205918004690 phosphorylation site [posttranslational modification] 205918004691 intermolecular recognition site; other site 205918004692 dimerization interface [polypeptide binding]; other site 205918004693 PAS domain S-box; Region: sensory_box; TIGR00229 205918004694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004695 putative active site [active] 205918004696 heme pocket [chemical binding]; other site 205918004697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004698 PAS domain; Region: PAS_9; pfam13426 205918004699 putative active site [active] 205918004700 heme pocket [chemical binding]; other site 205918004701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918004702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918004703 dimer interface [polypeptide binding]; other site 205918004704 phosphorylation site [posttranslational modification] 205918004705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918004706 ATP binding site [chemical binding]; other site 205918004707 Mg2+ binding site [ion binding]; other site 205918004708 G-X-G motif; other site 205918004709 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 205918004710 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 205918004711 putative aromatic amino acid binding site; other site 205918004712 PAS domain; Region: PAS; smart00091 205918004713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918004714 Walker A motif; other site 205918004715 ATP binding site [chemical binding]; other site 205918004716 Walker B motif; other site 205918004717 arginine finger; other site 205918004718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 205918004719 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004720 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004721 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 205918004722 heme binding pocket [chemical binding]; other site 205918004723 heme ligand [chemical binding]; other site 205918004724 Secretin and TonB N terminus short domain; Region: STN; smart00965 205918004725 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 205918004726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918004727 N-terminal plug; other site 205918004728 ligand-binding site [chemical binding]; other site 205918004729 fec operon regulator FecR; Reviewed; Region: PRK09774 205918004730 FecR protein; Region: FecR; pfam04773 205918004731 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 205918004732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918004733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918004734 DNA binding residues [nucleotide binding] 205918004735 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 205918004736 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 205918004737 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205918004738 phosphogluconate dehydratase; Validated; Region: PRK09054 205918004739 6-phosphogluconate dehydratase; Region: edd; TIGR01196 205918004740 glucokinase; Provisional; Region: glk; PRK00292 205918004741 glucokinase, proteobacterial type; Region: glk; TIGR00749 205918004742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918004743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004744 active site 205918004745 phosphorylation site [posttranslational modification] 205918004746 intermolecular recognition site; other site 205918004747 dimerization interface [polypeptide binding]; other site 205918004748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918004749 DNA binding site [nucleotide binding] 205918004750 HAMP domain; Region: HAMP; pfam00672 205918004751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918004752 ATP binding site [chemical binding]; other site 205918004753 Mg2+ binding site [ion binding]; other site 205918004754 G-X-G motif; other site 205918004755 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004756 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004757 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918004758 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205918004759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004760 dimer interface [polypeptide binding]; other site 205918004761 conserved gate region; other site 205918004762 putative PBP binding loops; other site 205918004763 ABC-ATPase subunit interface; other site 205918004764 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004765 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004766 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004767 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004768 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004769 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004770 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004772 dimer interface [polypeptide binding]; other site 205918004773 conserved gate region; other site 205918004774 putative PBP binding loops; other site 205918004775 ABC-ATPase subunit interface; other site 205918004776 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004777 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004778 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004779 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004780 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004781 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004782 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004783 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918004784 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 205918004785 Walker A/P-loop; other site 205918004786 ATP binding site [chemical binding]; other site 205918004787 Q-loop/lid; other site 205918004788 ABC transporter signature motif; other site 205918004789 Walker B; other site 205918004790 D-loop; other site 205918004791 H-loop/switch region; other site 205918004792 TOBE domain; Region: TOBE_2; pfam08402 205918004793 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 205918004794 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 205918004795 active site 205918004796 phosphate binding residues; other site 205918004797 catalytic residues [active] 205918004798 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 205918004799 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205918004800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918004801 putative active site [active] 205918004802 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 205918004803 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 205918004804 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 205918004805 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 205918004806 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 205918004807 putative active site [active] 205918004808 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 205918004809 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 205918004810 active site 205918004811 intersubunit interface [polypeptide binding]; other site 205918004812 catalytic residue [active] 205918004813 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 205918004814 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 205918004815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918004816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004817 metal binding site [ion binding]; metal-binding site 205918004818 active site 205918004819 I-site; other site 205918004820 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004821 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004822 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918004823 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918004824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918004825 dimer interface [polypeptide binding]; other site 205918004826 phosphorylation site [posttranslational modification] 205918004827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918004828 ATP binding site [chemical binding]; other site 205918004829 Mg2+ binding site [ion binding]; other site 205918004830 G-X-G motif; other site 205918004831 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004832 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004833 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918004834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004835 active site 205918004836 phosphorylation site [posttranslational modification] 205918004837 intermolecular recognition site; other site 205918004838 dimerization interface [polypeptide binding]; other site 205918004839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918004840 DNA binding site [nucleotide binding] 205918004841 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 205918004842 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004843 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004844 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004845 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004846 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004847 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004848 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004849 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004850 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004851 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004852 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004853 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004854 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918004855 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918004856 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918004857 1 probable transmembrane helix predicted by TMHMM2.0 205918004858 1 probable transmembrane helix predicted by TMHMM2.0 205918004859 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 205918004860 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 205918004861 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 205918004862 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 205918004863 1 probable transmembrane helix predicted by TMHMM2.0 205918004864 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 205918004865 PapC N-terminal domain; Region: PapC_N; pfam13954 205918004866 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 205918004867 PapC C-terminal domain; Region: PapC_C; pfam13953 205918004868 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 205918004869 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 205918004870 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 205918004871 Fimbrial protein; Region: Fimbrial; pfam00419 205918004872 Flagellin N-methylase; Region: FliB; pfam03692 205918004873 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 205918004874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918004875 Coenzyme A binding pocket [chemical binding]; other site 205918004876 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 205918004877 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918004878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004879 active site 205918004880 phosphorylation site [posttranslational modification] 205918004881 intermolecular recognition site; other site 205918004882 dimerization interface [polypeptide binding]; other site 205918004883 disulfide bond formation protein B; Provisional; Region: PRK02110 205918004884 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004885 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004886 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004887 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004888 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 205918004889 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 205918004890 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 205918004891 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004892 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004893 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004894 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 205918004895 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 205918004896 D-pathway; other site 205918004897 Putative ubiquinol binding site [chemical binding]; other site 205918004898 Low-spin heme (heme b) binding site [chemical binding]; other site 205918004899 Putative water exit pathway; other site 205918004900 Binuclear center (heme o3/CuB) [ion binding]; other site 205918004901 K-pathway; other site 205918004902 Putative proton exit pathway; other site 205918004903 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004904 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004905 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004906 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004907 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004908 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004909 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004910 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004911 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004912 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004913 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004914 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004915 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004916 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004917 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 205918004918 Subunit I/III interface [polypeptide binding]; other site 205918004919 Subunit III/IV interface [polypeptide binding]; other site 205918004920 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004921 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004922 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004923 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004924 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004925 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 205918004926 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004927 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004928 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004929 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 205918004930 UbiA prenyltransferase family; Region: UbiA; pfam01040 205918004931 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004932 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004933 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004934 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004935 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004936 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004937 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004938 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004939 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004940 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918004941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918004942 active site 205918004943 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 205918004944 trimer interface [polypeptide binding]; other site 205918004945 active site 205918004946 substrate binding site [chemical binding]; other site 205918004947 CoA binding site [chemical binding]; other site 205918004948 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 205918004949 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 205918004950 homodimer interface [polypeptide binding]; other site 205918004951 substrate-cofactor binding pocket; other site 205918004952 catalytic residue [active] 205918004953 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918004954 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918004955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918004956 dimer interface [polypeptide binding]; other site 205918004957 putative CheW interface [polypeptide binding]; other site 205918004958 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004959 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918004961 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918004962 substrate binding pocket [chemical binding]; other site 205918004963 membrane-bound complex binding site; other site 205918004964 hinge residues; other site 205918004965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918004966 dimerization interface [polypeptide binding]; other site 205918004967 putative DNA binding site [nucleotide binding]; other site 205918004968 putative Zn2+ binding site [ion binding]; other site 205918004969 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918004970 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 205918004971 putative NAD(P) binding site [chemical binding]; other site 205918004972 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 205918004973 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 205918004974 E-class dimer interface [polypeptide binding]; other site 205918004975 P-class dimer interface [polypeptide binding]; other site 205918004976 active site 205918004977 Cu2+ binding site [ion binding]; other site 205918004978 Zn2+ binding site [ion binding]; other site 205918004979 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 205918004980 hypothetical protein; Provisional; Region: PRK06156 205918004981 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 205918004982 active site 205918004983 metal binding site [ion binding]; metal-binding site 205918004984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004985 PAS domain; Region: PAS_9; pfam13426 205918004986 putative active site [active] 205918004987 heme pocket [chemical binding]; other site 205918004988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004989 PAS domain; Region: PAS_9; pfam13426 205918004990 putative active site [active] 205918004991 heme pocket [chemical binding]; other site 205918004992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918004993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004994 metal binding site [ion binding]; metal-binding site 205918004995 active site 205918004996 I-site; other site 205918004997 GntP family permease; Region: GntP_permease; pfam02447 205918004998 fructuronate transporter; Provisional; Region: PRK10034; cl15264 205918004999 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005000 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005001 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005002 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005003 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005004 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005005 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005006 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005007 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005008 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005009 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005010 PAS domain; Region: PAS; smart00091 205918005011 PAS domain; Region: PAS_9; pfam13426 205918005012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918005013 putative active site [active] 205918005014 heme pocket [chemical binding]; other site 205918005015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918005016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918005017 metal binding site [ion binding]; metal-binding site 205918005018 active site 205918005019 I-site; other site 205918005020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918005021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 205918005022 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918005023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918005024 DNA-binding site [nucleotide binding]; DNA binding site 205918005025 FCD domain; Region: FCD; pfam07729 205918005026 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 205918005027 Isochorismatase family; Region: Isochorismatase; pfam00857 205918005028 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918005029 catalytic triad [active] 205918005030 conserved cis-peptide bond; other site 205918005031 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 205918005032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918005033 Walker A/P-loop; other site 205918005034 ATP binding site [chemical binding]; other site 205918005035 Q-loop/lid; other site 205918005036 ABC transporter signature motif; other site 205918005037 Walker B; other site 205918005038 D-loop; other site 205918005039 H-loop/switch region; other site 205918005040 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918005041 Isochorismatase family; Region: Isochorismatase; pfam00857 205918005042 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918005043 catalytic triad [active] 205918005044 conserved cis-peptide bond; other site 205918005045 formamidase; Provisional; Region: amiF; PRK13287 205918005046 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 205918005047 multimer interface [polypeptide binding]; other site 205918005048 active site 205918005049 catalytic triad [active] 205918005050 dimer interface [polypeptide binding]; other site 205918005051 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205918005052 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918005053 TM-ABC transporter signature motif; other site 205918005054 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005055 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005056 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005057 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005058 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005059 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005060 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005061 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005062 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918005063 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918005064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918005065 TM-ABC transporter signature motif; other site 205918005066 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005067 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005068 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005069 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005070 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005071 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005072 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005073 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005074 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005075 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005076 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 205918005077 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 205918005078 putative ligand binding site [chemical binding]; other site 205918005079 allophanate hydrolase; Provisional; Region: PRK08186 205918005080 Amidase; Region: Amidase; cl11426 205918005081 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 205918005082 dimer interface [polypeptide binding]; other site 205918005083 ligand binding site [chemical binding]; other site 205918005084 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918005085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918005086 putative DNA binding site [nucleotide binding]; other site 205918005087 putative Zn2+ binding site [ion binding]; other site 205918005088 AsnC family; Region: AsnC_trans_reg; pfam01037 205918005089 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918005090 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005091 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005092 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005093 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005094 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005095 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005096 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 205918005097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918005098 putative substrate translocation pore; other site 205918005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918005100 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005101 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005102 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005103 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005104 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005105 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005106 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005107 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005108 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005109 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005110 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005111 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005112 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918005113 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 205918005114 putative C-terminal domain interface [polypeptide binding]; other site 205918005115 putative GSH binding site (G-site) [chemical binding]; other site 205918005116 putative dimer interface [polypeptide binding]; other site 205918005117 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 205918005118 putative N-terminal domain interface [polypeptide binding]; other site 205918005119 putative dimer interface [polypeptide binding]; other site 205918005120 putative substrate binding pocket (H-site) [chemical binding]; other site 205918005121 putative transposase OrfB; Reviewed; Region: PHA02517 205918005122 HTH-like domain; Region: HTH_21; pfam13276 205918005123 Integrase core domain; Region: rve; pfam00665 205918005124 Integrase core domain; Region: rve_2; pfam13333 205918005125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918005126 Helix-turn-helix domain; Region: HTH_28; pfam13518 205918005127 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 205918005128 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 205918005129 OPT oligopeptide transporter protein; Region: OPT; pfam03169 205918005130 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005131 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005132 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005133 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005134 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005135 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005136 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005137 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005138 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005139 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005140 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005141 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005142 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918005143 AAA domain; Region: AAA_33; pfam13671 205918005144 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 205918005145 active site 205918005146 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 205918005147 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 205918005148 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005149 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005150 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005151 Pectate lyase; Region: Pectate_lyase; pfam03211 205918005152 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 205918005153 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 205918005154 Pathogenicity factor; Region: AvrE; pfam11725 205918005155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918005156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918005157 catalytic residue [active] 205918005158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918005159 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 205918005160 Walker A motif; other site 205918005161 ATP binding site [chemical binding]; other site 205918005162 Walker B motif; other site 205918005163 arginine finger; other site 205918005164 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918005165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918005166 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918005167 Walker A motif; other site 205918005168 ATP binding site [chemical binding]; other site 205918005169 Walker B motif; other site 205918005170 arginine finger; other site 205918005171 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918005172 HrpA pilus formation protein; Region: HrpA_pilin; pfam09589 205918005173 HrpZ; Region: Hairpins; pfam04877 205918005174 HrpZ; Region: Hairpins; pfam04877 205918005175 Type III secretion needle MxiH like; Region: MxiH; pfam09392 205918005176 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 205918005177 1 probable transmembrane helix predicted by TMHMM2.0 205918005178 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 205918005179 HrpF protein; Region: HrpF; pfam06266 205918005180 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 205918005181 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918005182 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918005183 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918005184 1 probable transmembrane helix predicted by TMHMM2.0 205918005185 AAA domain; Region: AAA_21; pfam13304 205918005186 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 205918005187 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 205918005188 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005189 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005190 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005191 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 205918005192 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005193 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005194 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005195 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005196 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005197 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005198 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 205918005199 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005200 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005201 type III secretion apparatus protein, YscR/HrcR family; Region: yscR; TIGR01102 205918005202 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005203 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005204 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005205 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005206 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 205918005207 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 205918005208 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 205918005209 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 205918005210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205918005211 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918005212 Walker A motif; other site 205918005213 ATP binding site [chemical binding]; other site 205918005214 Walker B motif; other site 205918005215 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 205918005216 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 205918005217 FHIPEP family; Region: FHIPEP; pfam00771 205918005218 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005219 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005220 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005221 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005222 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005223 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005224 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005225 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 205918005226 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 205918005227 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 205918005228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918005229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918005230 DNA binding residues [nucleotide binding] 205918005231 1 probable transmembrane helix predicted by TMHMM2.0 205918005232 Avirulence protein; Region: AvrB_AvrC; pfam05394 205918005233 Transposase IS66 205918005234 ISPsy5, transposase 205918005235 IS66 Orf2 like 205918005236 YopJ Serine/Threonine acetyltransferase; Region: YopJ; pfam03421 205918005237 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 205918005238 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 205918005239 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 205918005240 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 205918005241 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 205918005242 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 205918005243 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 205918005244 1 probable transmembrane helix predicted by TMHMM2.0 205918005245 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 205918005246 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 205918005247 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 205918005248 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 205918005249 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005250 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005251 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005252 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005253 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005254 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005255 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 205918005256 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 205918005257 Protein export membrane protein; Region: SecD_SecF; pfam02355 205918005258 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005259 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005260 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005261 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005262 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005263 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005264 hypothetical protein; Provisional; Region: PRK11280 205918005265 1 probable transmembrane helix predicted by TMHMM2.0 205918005266 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 205918005267 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 205918005268 active site 205918005269 dimerization interface [polypeptide binding]; other site 205918005270 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 205918005271 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 205918005272 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 205918005273 serine O-acetyltransferase; Region: cysE; TIGR01172 205918005274 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 205918005275 trimer interface [polypeptide binding]; other site 205918005276 active site 205918005277 substrate binding site [chemical binding]; other site 205918005278 CoA binding site [chemical binding]; other site 205918005279 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 205918005280 Rrf2 family protein; Region: rrf2_super; TIGR00738 205918005281 cysteine desulfurase; Provisional; Region: PRK14012 205918005282 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 205918005283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918005284 catalytic residue [active] 205918005285 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 205918005286 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 205918005287 trimerization site [polypeptide binding]; other site 205918005288 active site 205918005289 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 205918005290 co-chaperone HscB; Provisional; Region: hscB; PRK00294 205918005291 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918005292 HSP70 interaction site [polypeptide binding]; other site 205918005293 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 205918005294 chaperone protein HscA; Provisional; Region: hscA; PRK05183 205918005295 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 205918005296 nucleotide binding site [chemical binding]; other site 205918005297 putative NEF/HSP70 interaction site [polypeptide binding]; other site 205918005298 SBD interface [polypeptide binding]; other site 205918005299 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 205918005300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918005301 catalytic loop [active] 205918005302 iron binding site [ion binding]; other site 205918005303 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 205918005304 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 205918005305 active site 205918005306 multimer interface [polypeptide binding]; other site 205918005307 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 205918005308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918005309 FeS/SAM binding site; other site 205918005310 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 205918005311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918005312 binding surface 205918005313 TPR motif; other site 205918005314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 205918005315 binding surface 205918005316 TPR motif; other site 205918005317 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 205918005318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918005319 non-specific DNA binding site [nucleotide binding]; other site 205918005320 salt bridge; other site 205918005321 sequence-specific DNA binding site [nucleotide binding]; other site 205918005322 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 205918005323 1 probable transmembrane helix predicted by TMHMM2.0 205918005324 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 205918005325 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205918005326 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205918005327 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 205918005328 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 205918005329 dimer interface [polypeptide binding]; other site 205918005330 motif 1; other site 205918005331 active site 205918005332 motif 2; other site 205918005333 motif 3; other site 205918005334 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 205918005335 anticodon binding site; other site 205918005336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 205918005337 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 205918005338 1 probable transmembrane helix predicted by TMHMM2.0 205918005339 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 205918005340 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 205918005341 Trp docking motif [polypeptide binding]; other site 205918005342 GTP-binding protein Der; Reviewed; Region: PRK00093 205918005343 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 205918005344 G1 box; other site 205918005345 GTP/Mg2+ binding site [chemical binding]; other site 205918005346 Switch I region; other site 205918005347 G2 box; other site 205918005348 Switch II region; other site 205918005349 G3 box; other site 205918005350 G4 box; other site 205918005351 G5 box; other site 205918005352 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 205918005353 G1 box; other site 205918005354 GTP/Mg2+ binding site [chemical binding]; other site 205918005355 Switch I region; other site 205918005356 G2 box; other site 205918005357 G3 box; other site 205918005358 Switch II region; other site 205918005359 G4 box; other site 205918005360 G5 box; other site 205918005361 methionine aminotransferase; Validated; Region: PRK09082 205918005362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918005363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918005364 homodimer interface [polypeptide binding]; other site 205918005365 catalytic residue [active] 205918005366 C-N hydrolase family amidase; Provisional; Region: PRK10438 205918005367 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 205918005368 putative active site [active] 205918005369 catalytic triad [active] 205918005370 dimer interface [polypeptide binding]; other site 205918005371 multimer interface [polypeptide binding]; other site 205918005372 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 205918005373 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918005374 tetramer interface [polypeptide binding]; other site 205918005375 active site 205918005376 Mg2+/Mn2+ binding site [ion binding]; other site 205918005377 2-isopropylmalate synthase; Validated; Region: PRK03739 205918005378 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 205918005379 active site 205918005380 catalytic residues [active] 205918005381 metal binding site [ion binding]; metal-binding site 205918005382 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 205918005383 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 205918005384 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918005385 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 205918005386 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 205918005387 generic binding surface II; other site 205918005388 generic binding surface I; other site 205918005389 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 205918005390 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 205918005391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 205918005392 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 205918005393 active site 205918005394 GMP synthase; Reviewed; Region: guaA; PRK00074 205918005395 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 205918005396 AMP/PPi binding site [chemical binding]; other site 205918005397 candidate oxyanion hole; other site 205918005398 catalytic triad [active] 205918005399 potential glutamine specificity residues [chemical binding]; other site 205918005400 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 205918005401 ATP Binding subdomain [chemical binding]; other site 205918005402 Ligand Binding sites [chemical binding]; other site 205918005403 Dimerization subdomain; other site 205918005404 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 205918005405 tetratricopeptide repeat protein; Provisional; Region: PRK11788 205918005406 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 205918005407 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 205918005408 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 205918005409 1 probable transmembrane helix predicted by TMHMM2.0 205918005410 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205918005411 nucleoside/Zn binding site; other site 205918005412 dimer interface [polypeptide binding]; other site 205918005413 catalytic motif [active] 205918005414 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 205918005415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918005416 substrate binding pocket [chemical binding]; other site 205918005417 membrane-bound complex binding site; other site 205918005418 hinge residues; other site 205918005419 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918005420 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918005421 catalytic residue [active] 205918005422 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 205918005423 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 205918005424 dimerization interface [polypeptide binding]; other site 205918005425 ATP binding site [chemical binding]; other site 205918005426 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 205918005427 dimerization interface [polypeptide binding]; other site 205918005428 ATP binding site [chemical binding]; other site 205918005429 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 205918005430 putative active site [active] 205918005431 catalytic triad [active] 205918005432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 205918005433 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205918005434 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 205918005435 nudix motif; other site 205918005436 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 205918005437 putative active site [active] 205918005438 putative CoA binding site [chemical binding]; other site 205918005439 nudix motif; other site 205918005440 metal binding site [ion binding]; metal-binding site 205918005441 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 205918005442 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 205918005443 trimer interface [polypeptide binding]; other site 205918005444 putative metal binding site [ion binding]; other site 205918005445 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 205918005446 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 205918005447 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005448 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005449 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005450 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005451 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 205918005452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918005453 ATP-grasp domain; Region: ATP-grasp; pfam02222 205918005454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918005455 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918005456 putative substrate translocation pore; other site 205918005457 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005458 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005459 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005460 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005461 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005462 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005463 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005464 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005465 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005466 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005467 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005468 Domain of unknown function DUF21; Region: DUF21; pfam01595 205918005469 hypothetical protein; Provisional; Region: PRK11573 205918005470 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918005471 Transporter associated domain; Region: CorC_HlyC; smart01091 205918005472 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005473 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005474 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005475 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005476 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 205918005477 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005478 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005479 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005480 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005481 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005482 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005483 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005484 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005485 signal recognition particle protein; Provisional; Region: PRK10867 205918005486 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 205918005487 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205918005488 P loop; other site 205918005489 GTP binding site [chemical binding]; other site 205918005490 Signal peptide binding domain; Region: SRP_SPB; pfam02978 205918005491 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 205918005492 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 205918005493 RimM N-terminal domain; Region: RimM; pfam01782 205918005494 PRC-barrel domain; Region: PRC; pfam05239 205918005495 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 205918005496 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 205918005497 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 205918005498 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 205918005499 active site 205918005500 Int/Topo IB signature motif; other site 205918005501 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 205918005502 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 205918005503 dimerization domain [polypeptide binding]; other site 205918005504 dimer interface [polypeptide binding]; other site 205918005505 catalytic residues [active] 205918005506 homoserine dehydrogenase; Provisional; Region: PRK06349 205918005507 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 205918005508 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 205918005509 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 205918005510 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 205918005511 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 205918005512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918005513 catalytic residue [active] 205918005514 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 205918005515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918005516 substrate binding pocket [chemical binding]; other site 205918005517 membrane-bound complex binding site; other site 205918005518 hinge residues; other site 205918005519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918005520 substrate binding pocket [chemical binding]; other site 205918005521 membrane-bound complex binding site; other site 205918005522 hinge residues; other site 205918005523 PAS domain; Region: PAS; smart00091 205918005524 putative active site [active] 205918005525 heme pocket [chemical binding]; other site 205918005526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918005527 dimer interface [polypeptide binding]; other site 205918005528 phosphorylation site [posttranslational modification] 205918005529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918005530 ATP binding site [chemical binding]; other site 205918005531 Mg2+ binding site [ion binding]; other site 205918005532 G-X-G motif; other site 205918005533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005534 active site 205918005535 phosphorylation site [posttranslational modification] 205918005536 intermolecular recognition site; other site 205918005537 dimerization interface [polypeptide binding]; other site 205918005538 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918005539 putative binding surface; other site 205918005540 active site 205918005541 1 probable transmembrane helix predicted by TMHMM2.0 205918005542 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005544 active site 205918005545 phosphorylation site [posttranslational modification] 205918005546 intermolecular recognition site; other site 205918005547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918005548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005550 active site 205918005551 phosphorylation site [posttranslational modification] 205918005552 intermolecular recognition site; other site 205918005553 dimerization interface [polypeptide binding]; other site 205918005554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918005555 DNA binding residues [nucleotide binding] 205918005556 dimerization interface [polypeptide binding]; other site 205918005557 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 205918005558 conserved hypothetical protein; Region: TIGR02285 205918005559 YaeQ protein; Region: YaeQ; pfam07152 205918005560 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 205918005561 DHH family; Region: DHH; pfam01368 205918005562 DHHA1 domain; Region: DHHA1; pfam02272 205918005563 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918005564 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 205918005565 active site 205918005566 FMN binding site [chemical binding]; other site 205918005567 substrate binding site [chemical binding]; other site 205918005568 homotetramer interface [polypeptide binding]; other site 205918005569 catalytic residue [active] 205918005570 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 205918005571 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918005572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918005573 putative active site [active] 205918005574 heme pocket [chemical binding]; other site 205918005575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918005576 dimer interface [polypeptide binding]; other site 205918005577 phosphorylation site [posttranslational modification] 205918005578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918005579 ATP binding site [chemical binding]; other site 205918005580 Mg2+ binding site [ion binding]; other site 205918005581 G-X-G motif; other site 205918005582 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005584 active site 205918005585 phosphorylation site [posttranslational modification] 205918005586 intermolecular recognition site; other site 205918005587 dimerization interface [polypeptide binding]; other site 205918005588 Protein of unknown function (DUF533); Region: DUF533; pfam04391 205918005589 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 205918005590 putative metal binding site [ion binding]; other site 205918005591 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 205918005592 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918005593 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918005594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918005595 dimerization interface [polypeptide binding]; other site 205918005596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918005597 dimer interface [polypeptide binding]; other site 205918005598 putative CheW interface [polypeptide binding]; other site 205918005599 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005600 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005601 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 205918005602 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 205918005603 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918005604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918005605 S-adenosylmethionine binding site [chemical binding]; other site 205918005606 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 205918005607 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918005608 putative binding surface; other site 205918005609 active site 205918005610 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 205918005611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918005612 ATP binding site [chemical binding]; other site 205918005613 Mg2+ binding site [ion binding]; other site 205918005614 G-X-G motif; other site 205918005615 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918005616 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005618 active site 205918005619 phosphorylation site [posttranslational modification] 205918005620 intermolecular recognition site; other site 205918005621 dimerization interface [polypeptide binding]; other site 205918005622 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 205918005623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005624 active site 205918005625 phosphorylation site [posttranslational modification] 205918005626 intermolecular recognition site; other site 205918005627 CheB methylesterase; Region: CheB_methylest; pfam01339 205918005628 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005630 active site 205918005631 phosphorylation site [posttranslational modification] 205918005632 intermolecular recognition site; other site 205918005633 dimerization interface [polypeptide binding]; other site 205918005634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918005635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918005636 metal binding site [ion binding]; metal-binding site 205918005637 active site 205918005638 I-site; other site 205918005639 peptide chain release factor 2; Region: prfB; TIGR00020 205918005640 This domain is found in peptide chain release factors; Region: PCRF; smart00937 205918005641 RF-1 domain; Region: RF-1; pfam00472 205918005642 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 205918005643 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 205918005644 dimer interface [polypeptide binding]; other site 205918005645 putative anticodon binding site; other site 205918005646 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 205918005647 motif 1; other site 205918005648 active site 205918005649 motif 2; other site 205918005650 motif 3; other site 205918005651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 205918005652 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 205918005653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918005654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918005655 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918005656 1 probable transmembrane helix predicted by TMHMM2.0 205918005657 CHASE3 domain; Region: CHASE3; cl05000 205918005658 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918005659 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918005660 ligand binding site [chemical binding]; other site 205918005661 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 205918005662 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 205918005663 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 205918005664 adenylate kinase; Reviewed; Region: adk; PRK00279 205918005665 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 205918005666 AMP-binding site [chemical binding]; other site 205918005667 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 205918005668 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 205918005669 Glycoprotease family; Region: Peptidase_M22; pfam00814 205918005670 Protein of unknown function DUF72; Region: DUF72; cl00777 205918005671 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 205918005672 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 205918005673 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 205918005674 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 205918005675 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 205918005676 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 205918005677 putative acyl-acceptor binding pocket; other site 205918005678 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 205918005679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918005680 S-adenosylmethionine binding site [chemical binding]; other site 205918005681 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 205918005682 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 205918005683 metal binding site [ion binding]; metal-binding site 205918005684 dimer interface [polypeptide binding]; other site 205918005685 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 205918005686 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918005687 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 205918005688 Ligand binding site; other site 205918005689 DXD motif; other site 205918005690 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005691 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005692 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005693 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005694 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005695 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005696 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005697 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 205918005698 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 205918005699 putative ATP binding site [chemical binding]; other site 205918005700 putative substrate interface [chemical binding]; other site 205918005701 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 205918005702 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 205918005703 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 205918005704 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918005705 catalytic residue [active] 205918005706 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 205918005707 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 205918005708 putative trimer interface [polypeptide binding]; other site 205918005709 putative CoA binding site [chemical binding]; other site 205918005710 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 205918005711 ArsC family; Region: ArsC; pfam03960 205918005712 putative catalytic residues [active] 205918005713 Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327 205918005714 active site 205918005715 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 205918005716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918005718 homodimer interface [polypeptide binding]; other site 205918005719 catalytic residue [active] 205918005720 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 205918005721 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918005722 metal binding triad; other site 205918005723 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205918005724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205918005725 Zn2+ binding site [ion binding]; other site 205918005726 Mg2+ binding site [ion binding]; other site 205918005727 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 205918005728 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 205918005729 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205918005730 active site 205918005731 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 205918005732 rRNA interaction site [nucleotide binding]; other site 205918005733 S8 interaction site; other site 205918005734 putative laminin-1 binding site; other site 205918005735 elongation factor Ts; Provisional; Region: tsf; PRK09377 205918005736 UBA/TS-N domain; Region: UBA; pfam00627 205918005737 Elongation factor TS; Region: EF_TS; pfam00889 205918005738 Elongation factor TS; Region: EF_TS; pfam00889 205918005739 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 205918005740 putative nucleotide binding site [chemical binding]; other site 205918005741 uridine monophosphate binding site [chemical binding]; other site 205918005742 homohexameric interface [polypeptide binding]; other site 205918005743 ribosome recycling factor; Reviewed; Region: frr; PRK00083 205918005744 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 205918005745 hinge region; other site 205918005746 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 205918005747 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 205918005748 catalytic residue [active] 205918005749 putative FPP diphosphate binding site; other site 205918005750 putative FPP binding hydrophobic cleft; other site 205918005751 dimer interface [polypeptide binding]; other site 205918005752 putative IPP diphosphate binding site; other site 205918005753 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 205918005754 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 205918005755 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005756 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005757 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005758 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005759 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005760 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005761 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005762 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 205918005763 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 205918005764 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 205918005765 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 205918005766 zinc metallopeptidase RseP; Provisional; Region: PRK10779 205918005767 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 205918005768 active site 205918005769 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 205918005770 protein binding site [polypeptide binding]; other site 205918005771 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 205918005772 protein binding site [polypeptide binding]; other site 205918005773 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 205918005774 putative substrate binding region [chemical binding]; other site 205918005775 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005776 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005777 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005778 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005779 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 205918005780 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918005781 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918005782 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918005783 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918005784 Surface antigen; Region: Bac_surface_Ag; pfam01103 205918005785 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 205918005786 periplasmic chaperone; Provisional; Region: PRK10780 205918005787 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 205918005788 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 205918005789 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 205918005790 trimer interface [polypeptide binding]; other site 205918005791 active site 205918005792 UDP-GlcNAc binding site [chemical binding]; other site 205918005793 lipid binding site [chemical binding]; lipid-binding site 205918005794 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 205918005795 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 205918005796 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 205918005797 active site 205918005798 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 205918005799 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 205918005800 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 205918005801 RNA/DNA hybrid binding site [nucleotide binding]; other site 205918005802 active site 205918005803 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 205918005804 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 205918005805 putative active site [active] 205918005806 putative PHP Thumb interface [polypeptide binding]; other site 205918005807 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 205918005808 generic binding surface II; other site 205918005809 generic binding surface I; other site 205918005810 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 205918005811 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 205918005812 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 205918005813 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 205918005814 Ligand Binding Site [chemical binding]; other site 205918005815 TilS substrate binding domain; Region: TilS; pfam09179 205918005816 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 205918005817 CTP synthetase; Validated; Region: pyrG; PRK05380 205918005818 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 205918005819 Catalytic site [active] 205918005820 active site 205918005821 UTP binding site [chemical binding]; other site 205918005822 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 205918005823 active site 205918005824 putative oxyanion hole; other site 205918005825 catalytic triad [active] 205918005826 1 probable transmembrane helix predicted by TMHMM2.0 205918005827 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 205918005828 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205918005829 enolase; Provisional; Region: eno; PRK00077 205918005830 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205918005831 dimer interface [polypeptide binding]; other site 205918005832 metal binding site [ion binding]; metal-binding site 205918005833 substrate binding pocket [chemical binding]; other site 205918005834 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 205918005835 Septum formation initiator; Region: DivIC; cl17659 205918005836 1 probable transmembrane helix predicted by TMHMM2.0 205918005837 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 205918005838 substrate binding site; other site 205918005839 dimer interface; other site 205918005840 1 probable transmembrane helix predicted by TMHMM2.0 205918005841 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918005842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918005843 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 205918005844 putative effector binding pocket; other site 205918005845 putative dimerization interface [polypeptide binding]; other site 205918005846 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 205918005847 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 205918005848 substrate binding site [chemical binding]; other site 205918005849 catalytic Zn binding site [ion binding]; other site 205918005850 NAD binding site [chemical binding]; other site 205918005851 structural Zn binding site [ion binding]; other site 205918005852 dimer interface [polypeptide binding]; other site 205918005853 S-formylglutathione hydrolase; Region: PLN02442 205918005854 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 205918005855 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 205918005856 homotrimer interaction site [polypeptide binding]; other site 205918005857 zinc binding site [ion binding]; other site 205918005858 CDP-binding sites; other site 205918005859 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 205918005860 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 205918005861 Permutation of conserved domain; other site 205918005862 active site 205918005863 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205918005864 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 205918005865 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 205918005866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918005867 S-adenosylmethionine binding site [chemical binding]; other site 205918005868 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 205918005869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918005870 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918005871 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 205918005872 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205918005873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918005874 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205918005875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918005876 DNA binding residues [nucleotide binding] 205918005877 Ferredoxin [Energy production and conversion]; Region: COG1146 205918005878 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 205918005879 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 205918005880 MutS domain I; Region: MutS_I; pfam01624 205918005881 MutS domain II; Region: MutS_II; pfam05188 205918005882 MutS domain III; Region: MutS_III; pfam05192 205918005883 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 205918005884 Walker A/P-loop; other site 205918005885 ATP binding site [chemical binding]; other site 205918005886 Q-loop/lid; other site 205918005887 ABC transporter signature motif; other site 205918005888 Walker B; other site 205918005889 D-loop; other site 205918005890 H-loop/switch region; other site 205918005891 Competence-damaged protein; Region: CinA; pfam02464 205918005892 recombinase A; Provisional; Region: recA; PRK09354 205918005893 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 205918005894 hexamer interface [polypeptide binding]; other site 205918005895 Walker A motif; other site 205918005896 ATP binding site [chemical binding]; other site 205918005897 Walker B motif; other site 205918005898 recombination regulator RecX; Reviewed; Region: recX; PRK00117 205918005899 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 205918005900 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 205918005901 Uncharacterized conserved protein [Function unknown]; Region: COG3148 205918005902 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918005903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005904 active site 205918005905 phosphorylation site [posttranslational modification] 205918005906 intermolecular recognition site; other site 205918005907 dimerization interface [polypeptide binding]; other site 205918005908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918005909 DNA binding residues [nucleotide binding] 205918005910 dimerization interface [polypeptide binding]; other site 205918005911 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 205918005912 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005913 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005914 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005915 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 205918005916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918005917 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 205918005918 putative dimerization interface [polypeptide binding]; other site 205918005919 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 205918005920 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 205918005921 FAD binding pocket [chemical binding]; other site 205918005922 FAD binding motif [chemical binding]; other site 205918005923 phosphate binding motif [ion binding]; other site 205918005924 beta-alpha-beta structure motif; other site 205918005925 NAD binding pocket [chemical binding]; other site 205918005926 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 205918005927 homodimer interaction site [polypeptide binding]; other site 205918005928 cofactor binding site; other site 205918005929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 205918005930 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 205918005931 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 205918005932 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 205918005933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918005934 RNA binding surface [nucleotide binding]; other site 205918005935 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 205918005936 active site 205918005937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918005938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918005939 Coenzyme A binding pocket [chemical binding]; other site 205918005940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918005941 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 205918005942 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205918005943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918005944 FeS/SAM binding site; other site 205918005945 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 205918005946 putative heme binding pocket [chemical binding]; other site 205918005947 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 205918005948 potassium uptake protein; Region: kup; TIGR00794 205918005949 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005950 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005951 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005952 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005953 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005954 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005955 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005956 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005957 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005958 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005959 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005960 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005961 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 205918005962 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 205918005963 1 probable transmembrane helix predicted by TMHMM2.0 205918005964 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 205918005965 Uncharacterized conserved protein [Function unknown]; Region: COG2898 205918005966 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 205918005967 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005968 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005969 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005970 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005971 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005972 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005973 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005974 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005975 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005976 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005977 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005978 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005979 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005980 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005981 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 205918005982 active site 205918005983 DNA polymerase IV; Validated; Region: PRK02406 205918005984 DNA binding site [nucleotide binding] 205918005985 prolyl-tRNA synthetase; Provisional; Region: PRK09194 205918005986 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 205918005987 dimer interface [polypeptide binding]; other site 205918005988 motif 1; other site 205918005989 active site 205918005990 motif 2; other site 205918005991 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 205918005992 putative deacylase active site [active] 205918005993 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205918005994 active site 205918005995 motif 3; other site 205918005996 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 205918005997 anticodon binding site; other site 205918005998 outer membrane porin, OprD family; Region: OprD; pfam03573 205918005999 HIT domain; Region: HIT; pfam01230 205918006000 nucleotide binding site/active site [active] 205918006001 HIT family signature motif; other site 205918006002 catalytic residue [active] 205918006003 hypothetical protein; Provisional; Region: PRK00295 205918006004 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205918006005 DNA-binding site [nucleotide binding]; DNA binding site 205918006006 RNA-binding motif; other site 205918006007 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 205918006008 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 205918006009 dimerization interface [polypeptide binding]; other site 205918006010 DPS ferroxidase diiron center [ion binding]; other site 205918006011 ion pore; other site 205918006012 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 205918006013 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 205918006014 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 205918006015 dimer interface [polypeptide binding]; other site 205918006016 anticodon binding site; other site 205918006017 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 205918006018 homodimer interface [polypeptide binding]; other site 205918006019 motif 1; other site 205918006020 active site 205918006021 motif 2; other site 205918006022 GAD domain; Region: GAD; pfam02938 205918006023 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205918006024 active site 205918006025 motif 3; other site 205918006026 hypothetical protein; Validated; Region: PRK00110 205918006027 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 205918006028 active site 205918006029 putative DNA-binding cleft [nucleotide binding]; other site 205918006030 dimer interface [polypeptide binding]; other site 205918006031 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 205918006032 RuvA N terminal domain; Region: RuvA_N; pfam01330 205918006033 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 205918006034 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 205918006035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918006036 Walker A motif; other site 205918006037 ATP binding site [chemical binding]; other site 205918006038 Walker B motif; other site 205918006039 arginine finger; other site 205918006040 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 205918006041 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918006042 active site 205918006043 TolQ protein; Region: tolQ; TIGR02796 205918006044 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006045 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006046 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006047 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918006048 TolR protein; Region: tolR; TIGR02801 205918006049 1 probable transmembrane helix predicted by TMHMM2.0 205918006050 TolA protein; Region: tolA_full; TIGR02794 205918006051 TolA protein; Region: tolA_full; TIGR02794 205918006052 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 205918006053 1 probable transmembrane helix predicted by TMHMM2.0 205918006054 translocation protein TolB; Provisional; Region: tolB; PRK00178 205918006055 TolB amino-terminal domain; Region: TolB_N; pfam04052 205918006056 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 205918006057 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 205918006058 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 205918006059 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918006060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918006061 ligand binding site [chemical binding]; other site 205918006062 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 205918006063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 205918006064 binding surface 205918006065 TPR motif; other site 205918006066 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 205918006067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918006068 FeS/SAM binding site; other site 205918006069 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 205918006070 Ligand Binding Site [chemical binding]; other site 205918006071 P-loop containing region of AAA domain; Region: AAA_29; cl17516 205918006072 AAA domain; Region: AAA_23; pfam13476 205918006073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918006074 ABC transporter signature motif; other site 205918006075 Walker B; other site 205918006076 D-loop; other site 205918006077 H-loop/switch region; other site 205918006078 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 205918006079 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 205918006080 active site 205918006081 catalytic residues [active] 205918006082 DNA binding site [nucleotide binding] 205918006083 Int/Topo IB signature motif; other site 205918006084 Putative helicase; Region: TraI_2; pfam07514 205918006085 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 205918006086 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 205918006087 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918006088 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918006089 Catalytic site [active] 205918006090 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 205918006091 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 205918006092 active site 205918006093 DNA binding site [nucleotide binding] 205918006094 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 205918006095 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 205918006096 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006097 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006098 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006099 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006100 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006101 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006102 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006103 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 205918006104 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 205918006105 integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757 205918006106 AZL_007950 family protein; Region: AZL_007950_fam; cl14861 205918006107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205918006108 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 205918006109 cofactor binding site; other site 205918006110 DNA binding site [nucleotide binding] 205918006111 substrate interaction site [chemical binding]; other site 205918006112 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 205918006113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918006114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918006115 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918006116 putative effector binding pocket; other site 205918006117 dimerization interface [polypeptide binding]; other site 205918006118 Major royal jelly protein; Region: MRJP; pfam03022 205918006119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918006120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918006121 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918006122 putative effector binding pocket; other site 205918006123 dimerization interface [polypeptide binding]; other site 205918006124 ISPpu14, transposase Orf3 205918006125 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918006126 Beta-lactamase; Region: Beta-lactamase; pfam00144 205918006127 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 205918006128 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 205918006129 catalytic residues [active] 205918006130 1 probable transmembrane helix predicted by TMHMM2.0 205918006131 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 205918006132 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 205918006133 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 205918006134 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 205918006135 Protein of unknown function (DUF972); Region: DUF972; pfam06156 205918006136 1 probable transmembrane helix predicted by TMHMM2.0 205918006137 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 205918006138 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 205918006139 1 probable transmembrane helix predicted by TMHMM2.0 205918006140 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 205918006141 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006142 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006143 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 205918006144 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006145 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006146 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006147 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 205918006148 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006149 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006150 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 205918006151 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 205918006152 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 205918006153 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 205918006154 Family description; Region: UvrD_C_2; pfam13538 205918006155 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 205918006156 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006157 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006158 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006159 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 205918006160 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 205918006161 1 probable transmembrane helix predicted by TMHMM2.0 205918006162 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 205918006163 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 205918006164 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 205918006165 1 probable transmembrane helix predicted by TMHMM2.0 205918006166 Cupin superfamily protein; Region: Cupin_4; pfam08007 205918006167 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006168 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006169 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006170 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006171 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006172 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006173 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006174 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006175 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006176 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918006178 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918006179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 205918006180 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 205918006181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 205918006182 putative Mg++ binding site [ion binding]; other site 205918006183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 205918006184 nucleotide binding region [chemical binding]; other site 205918006185 ATP-binding site [chemical binding]; other site 205918006186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918006187 S-adenosylmethionine binding site [chemical binding]; other site 205918006188 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 205918006189 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 205918006190 DNA topoisomerase III; Provisional; Region: PRK07726 205918006191 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 205918006192 active site 205918006193 putative interdomain interaction site [polypeptide binding]; other site 205918006194 putative metal-binding site [ion binding]; other site 205918006195 putative nucleotide binding site [chemical binding]; other site 205918006196 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205918006197 domain I; other site 205918006198 DNA binding groove [nucleotide binding] 205918006199 phosphate binding site [ion binding]; other site 205918006200 domain II; other site 205918006201 domain III; other site 205918006202 nucleotide binding site [chemical binding]; other site 205918006203 catalytic site [active] 205918006204 domain IV; other site 205918006205 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205918006206 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918006207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918006208 active site 205918006209 DNA binding site [nucleotide binding] 205918006210 Int/Topo IB signature motif; other site 205918006211 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 205918006212 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 205918006213 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 205918006214 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 205918006215 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 205918006216 1 probable transmembrane helix predicted by TMHMM2.0 205918006217 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 205918006218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918006219 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 205918006220 putative dimerization interface [polypeptide binding]; other site 205918006221 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 205918006222 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 205918006223 gating phenylalanine in ion channel; other site 205918006224 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006225 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006226 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006227 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006228 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006229 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006230 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006231 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006232 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006233 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006234 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 205918006235 putative uracil binding site [chemical binding]; other site 205918006236 putative active site [active] 205918006237 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205918006238 dimer interface [polypeptide binding]; other site 205918006239 substrate binding site [chemical binding]; other site 205918006240 metal binding sites [ion binding]; metal-binding site 205918006241 enolase; Provisional; Region: eno; PRK00077 205918006242 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205918006243 dimer interface [polypeptide binding]; other site 205918006244 metal binding site [ion binding]; metal-binding site 205918006245 substrate binding pocket [chemical binding]; other site 205918006246 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 205918006247 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 205918006248 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 205918006249 putative Cl- selectivity filter; other site 205918006250 putative pore gating glutamate residue; other site 205918006251 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006252 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006253 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006254 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006255 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006256 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006257 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006258 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006259 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006260 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 205918006261 Sodium Bile acid symporter family; Region: SBF; cl17470 205918006262 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006263 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006264 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006265 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006266 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006267 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006268 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006269 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006270 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 205918006271 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918006272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918006273 dimerization interface [polypeptide binding]; other site 205918006274 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918006275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918006276 dimer interface [polypeptide binding]; other site 205918006277 putative CheW interface [polypeptide binding]; other site 205918006278 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006279 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006280 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918006281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918006282 active site 205918006283 DNA binding site [nucleotide binding] 205918006284 Int/Topo IB signature motif; other site 205918006285 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 205918006286 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 205918006287 Multicopper oxidase; Region: Cu-oxidase; pfam00394 205918006288 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 205918006289 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 205918006290 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 205918006291 1 probable transmembrane helix predicted by TMHMM2.0 205918006292 CopC domain; Region: CopC; pfam04234 205918006293 Copper resistance protein D; Region: CopD; cl00563 205918006294 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006295 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006296 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006297 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006298 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006299 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006300 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006301 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006302 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918006303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918006304 active site 205918006305 phosphorylation site [posttranslational modification] 205918006306 intermolecular recognition site; other site 205918006307 dimerization interface [polypeptide binding]; other site 205918006308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918006309 DNA binding site [nucleotide binding] 205918006310 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918006311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918006312 dimerization interface [polypeptide binding]; other site 205918006313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918006314 dimer interface [polypeptide binding]; other site 205918006315 phosphorylation site [posttranslational modification] 205918006316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918006317 ATP binding site [chemical binding]; other site 205918006318 Mg2+ binding site [ion binding]; other site 205918006319 G-X-G motif; other site 205918006320 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006321 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006322 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006323 Predicted metal-binding protein [General function prediction only]; Region: COG3019 205918006324 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918006325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918006326 Coenzyme A binding pocket [chemical binding]; other site 205918006327 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 205918006328 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918006329 Low molecular weight phosphatase family; Region: LMWPc; cl00105 205918006330 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 205918006331 active site 205918006332 arsenical pump membrane protein; Provisional; Region: PRK15445 205918006333 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 205918006334 transmembrane helices; other site 205918006335 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006336 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006337 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006338 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006339 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006340 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006341 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006342 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006343 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006344 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006345 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918006347 dimerization interface [polypeptide binding]; other site 205918006348 putative DNA binding site [nucleotide binding]; other site 205918006349 putative Zn2+ binding site [ion binding]; other site 205918006350 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 205918006351 putative metal binding site [ion binding]; other site 205918006352 putative homodimer interface [polypeptide binding]; other site 205918006353 putative homotetramer interface [polypeptide binding]; other site 205918006354 putative homodimer-homodimer interface [polypeptide binding]; other site 205918006355 putative allosteric switch controlling residues; other site 205918006356 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 205918006357 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 205918006358 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006359 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006360 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006361 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006362 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006363 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006364 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918006365 active site 205918006366 DNA binding site [nucleotide binding] 205918006367 Int/Topo IB signature motif; other site 205918006368 PilM; Region: PilM; pfam07419 205918006369 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 205918006370 1 probable transmembrane helix predicted by TMHMM2.0 205918006371 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918006372 Walker A motif; other site 205918006373 ATP binding site [chemical binding]; other site 205918006374 Walker B motif; other site 205918006375 PilS N terminal; Region: PilS; pfam08805 205918006376 1 probable transmembrane helix predicted by TMHMM2.0 205918006377 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918006378 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918006379 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006380 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006381 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006382 Type II/IV secretion system protein; Region: T2SE; pfam00437 205918006383 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918006384 Walker A motif; other site 205918006385 ATP binding site [chemical binding]; other site 205918006386 Walker B motif; other site 205918006387 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 205918006388 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 205918006389 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 205918006390 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 205918006391 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918006392 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 205918006393 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 205918006394 SEC-C motif; Region: SEC-C; pfam02810 205918006395 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918006396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918006397 ATP binding site [chemical binding]; other site 205918006398 putative Mg++ binding site [ion binding]; other site 205918006399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918006400 nucleotide binding region [chemical binding]; other site 205918006401 ATP-binding site [chemical binding]; other site 205918006402 1 probable transmembrane helix predicted by TMHMM2.0 205918006403 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205918006404 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205918006405 ssDNA binding site [nucleotide binding]; other site 205918006406 dimer interface [polypeptide binding]; other site 205918006407 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205918006408 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 205918006409 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 205918006410 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 205918006411 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 205918006412 ParB-like nuclease domain; Region: ParBc; pfam02195 205918006413 Arc-like DNA binding domain; Region: Arc; pfam03869 205918006414 replicative DNA helicase; Region: DnaB; TIGR00665 205918006415 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205918006416 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205918006417 Walker A motif; other site 205918006418 ATP binding site [chemical binding]; other site 205918006419 Walker B motif; other site 205918006420 DNA binding loops [nucleotide binding] 205918006421 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 205918006422 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918006423 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006424 P-loop; other site 205918006425 Magnesium ion binding site [ion binding]; other site 205918006426 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006427 Magnesium ion binding site [ion binding]; other site 205918006428 hypothetical protein 205918006429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918006430 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 205918006431 indole acetimide hydrolase; Validated; Region: PRK07488 205918006432 Amidase; Region: Amidase; pfam01425 205918006433 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 205918006434 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 205918006435 HAMP domain; Region: HAMP; pfam00672 205918006436 dimerization interface [polypeptide binding]; other site 205918006437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918006438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918006439 dimer interface [polypeptide binding]; other site 205918006440 putative CheW interface [polypeptide binding]; other site 205918006441 1 probable transmembrane helix predicted by TMHMM2.0 205918006442 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205918006443 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 205918006444 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006445 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006446 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006447 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006448 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006449 quinolinate synthetase; Provisional; Region: PRK09375 205918006450 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 205918006451 Peptidase family M48; Region: Peptidase_M48; cl12018 205918006452 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 205918006453 CPxP motif; other site 205918006454 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205918006455 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918006456 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006457 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006458 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006459 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006460 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006461 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006462 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006463 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 205918006464 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 205918006465 catalytic triad [active] 205918006466 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 205918006467 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 205918006468 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 205918006469 dihydrodipicolinate synthase; Region: dapA; TIGR00674 205918006470 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 205918006471 dimer interface [polypeptide binding]; other site 205918006472 active site 205918006473 catalytic residue [active] 205918006474 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 205918006475 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 205918006476 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 205918006477 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 205918006478 ATP binding site [chemical binding]; other site 205918006479 active site 205918006480 substrate binding site [chemical binding]; other site 205918006481 site-specific recombinase, phage integrase family 205918006482 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006483 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006484 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006485 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006486 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006487 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006488 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918006489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006490 P-loop; other site 205918006491 Magnesium ion binding site [ion binding]; other site 205918006492 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006493 Magnesium ion binding site [ion binding]; other site 205918006494 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918006495 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 205918006496 FMN binding site [chemical binding]; other site 205918006497 active site 205918006498 substrate binding site [chemical binding]; other site 205918006499 catalytic residue [active] 205918006500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918006501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918006502 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 205918006503 putative effector binding pocket; other site 205918006504 putative dimerization interface [polypeptide binding]; other site 205918006505 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 205918006506 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918006507 malate dehydrogenase; Provisional; Region: PRK13529 205918006508 Malic enzyme, N-terminal domain; Region: malic; pfam00390 205918006509 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 205918006510 NAD(P) binding site [chemical binding]; other site 205918006511 putative metal dependent hydrolase; Provisional; Region: PRK11598 205918006512 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 205918006513 Sulfatase; Region: Sulfatase; pfam00884 205918006514 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006515 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006516 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006517 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006518 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006519 ribonuclease D; Region: rnd; TIGR01388 205918006520 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 205918006521 catalytic site [active] 205918006522 putative active site [active] 205918006523 putative substrate binding site [chemical binding]; other site 205918006524 HRDC domain; Region: HRDC; pfam00570 205918006525 YcgL domain; Region: YcgL; cl01189 205918006526 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 205918006527 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205918006528 NAD binding site [chemical binding]; other site 205918006529 ligand binding site [chemical binding]; other site 205918006530 catalytic site [active] 205918006531 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 205918006532 putative FMN binding site [chemical binding]; other site 205918006533 hypothetical protein; Provisional; Region: PRK05170 205918006534 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 205918006535 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 205918006536 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 205918006537 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 205918006538 Multicopper oxidase; Region: Cu-oxidase; pfam00394 205918006539 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 205918006540 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 205918006541 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 205918006542 active site 205918006543 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918006544 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 205918006545 ligand binding site [chemical binding]; other site 205918006546 flexible hinge region; other site 205918006547 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 205918006548 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918006549 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006550 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006551 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 205918006552 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 205918006553 putative active site [active] 205918006554 putative dimer interface [polypeptide binding]; other site 205918006555 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 205918006556 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006557 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006558 WbqC-like protein family; Region: WbqC; pfam08889 205918006559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 205918006560 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918006561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918006562 Walker A motif; other site 205918006563 ATP binding site [chemical binding]; other site 205918006564 Walker B motif; other site 205918006565 arginine finger; other site 205918006566 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 205918006567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918006568 salt bridge; other site 205918006569 non-specific DNA binding site [nucleotide binding]; other site 205918006570 sequence-specific DNA binding site [nucleotide binding]; other site 205918006571 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918006572 1 probable transmembrane helix predicted by TMHMM2.0 205918006573 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 205918006574 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205918006575 dimer interface [polypeptide binding]; other site 205918006576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006577 catalytic residue [active] 205918006578 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 205918006579 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006580 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006581 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 205918006582 Na binding site [ion binding]; other site 205918006583 PAS domain; Region: PAS; smart00091 205918006584 PAS fold; Region: PAS_7; pfam12860 205918006585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918006586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918006587 dimer interface [polypeptide binding]; other site 205918006588 phosphorylation site [posttranslational modification] 205918006589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918006590 ATP binding site [chemical binding]; other site 205918006591 Mg2+ binding site [ion binding]; other site 205918006592 G-X-G motif; other site 205918006593 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918006594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918006595 active site 205918006596 phosphorylation site [posttranslational modification] 205918006597 intermolecular recognition site; other site 205918006598 dimerization interface [polypeptide binding]; other site 205918006599 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006600 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006601 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006602 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006603 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006604 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006605 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006606 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006607 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006608 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006609 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006610 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006611 H+ Antiporter protein; Region: 2A0121; TIGR00900 205918006612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006613 putative substrate translocation pore; other site 205918006614 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918006615 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918006616 putative acyl-acceptor binding pocket; other site 205918006617 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006618 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006619 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006620 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006621 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006622 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006623 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006624 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006625 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006626 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006627 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006628 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 205918006629 Sodium Bile acid symporter family; Region: SBF; pfam01758 205918006630 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006631 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006632 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006633 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006634 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006635 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006636 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006637 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006638 recombination associated protein; Reviewed; Region: rdgC; PRK00321 205918006639 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 205918006640 CoA-transferase family III; Region: CoA_transf_3; pfam02515 205918006641 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 205918006642 dimer interface [polypeptide binding]; other site 205918006643 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918006644 metal binding site [ion binding]; metal-binding site 205918006645 Cupin domain; Region: Cupin_2; cl17218 205918006646 1 probable transmembrane helix predicted by TMHMM2.0 205918006647 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 205918006648 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 205918006649 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 205918006650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918006651 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 205918006652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918006653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205918006654 non-specific DNA binding site [nucleotide binding]; other site 205918006655 salt bridge; other site 205918006656 sequence-specific DNA binding site [nucleotide binding]; other site 205918006657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918006658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 205918006659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918006660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918006661 metal binding site [ion binding]; metal-binding site 205918006662 active site 205918006663 I-site; other site 205918006664 carboxy-terminal protease; Provisional; Region: PRK11186 205918006665 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 205918006666 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 205918006667 protein binding site [polypeptide binding]; other site 205918006668 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 205918006669 Catalytic dyad [active] 205918006670 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 205918006671 1 probable transmembrane helix predicted by TMHMM2.0 205918006672 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 205918006673 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 205918006674 NAD(P) binding site [chemical binding]; other site 205918006675 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 205918006676 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 205918006677 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918006678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918006679 Walker A/P-loop; other site 205918006680 ATP binding site [chemical binding]; other site 205918006681 Q-loop/lid; other site 205918006682 ABC transporter signature motif; other site 205918006683 Walker B; other site 205918006684 D-loop; other site 205918006685 H-loop/switch region; other site 205918006686 TOBE domain; Region: TOBE_2; pfam08402 205918006687 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918006688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918006689 dimer interface [polypeptide binding]; other site 205918006690 conserved gate region; other site 205918006691 putative PBP binding loops; other site 205918006692 ABC-ATPase subunit interface; other site 205918006693 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006694 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006695 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006696 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006697 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006698 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006699 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006700 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918006701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918006702 dimer interface [polypeptide binding]; other site 205918006703 conserved gate region; other site 205918006704 putative PBP binding loops; other site 205918006705 ABC-ATPase subunit interface; other site 205918006706 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006707 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006708 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006709 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006710 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006711 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006712 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 205918006713 PglZ domain; Region: PglZ; pfam08665 205918006714 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 205918006715 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205918006716 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918006717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918006718 transcriptional regulator protein; Region: phnR; TIGR03337 205918006719 DNA-binding site [nucleotide binding]; DNA binding site 205918006720 UTRA domain; Region: UTRA; pfam07702 205918006721 hypothetical protein; Provisional; Region: PRK09946 205918006722 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 205918006723 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 205918006724 active site 205918006725 metal binding site [ion binding]; metal-binding site 205918006726 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205918006727 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205918006728 active site 205918006729 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 205918006730 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 205918006731 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 205918006732 Switch I; other site 205918006733 Switch II; other site 205918006734 septum formation inhibitor; Reviewed; Region: minC; PRK00339 205918006735 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 205918006736 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 205918006737 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 205918006738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 205918006739 putative acyl-acceptor binding pocket; other site 205918006740 1 probable transmembrane helix predicted by TMHMM2.0 205918006741 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 205918006742 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 205918006743 active site 205918006744 nucleophile elbow; other site 205918006745 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 205918006746 iron-sulfur cluster [ion binding]; other site 205918006747 [2Fe-2S] cluster binding site [ion binding]; other site 205918006748 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 205918006749 inhibitor site; inhibition site 205918006750 active site 205918006751 dimer interface [polypeptide binding]; other site 205918006752 catalytic residue [active] 205918006753 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918006754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918006755 catalytic residue [active] 205918006756 Autoinducer synthetase; Region: Autoind_synth; pfam00765 205918006757 Autoinducer binding domain; Region: Autoind_bind; pfam03472 205918006758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918006759 DNA binding residues [nucleotide binding] 205918006760 dimerization interface [polypeptide binding]; other site 205918006761 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 205918006762 MarR family; Region: MarR_2; pfam12802 205918006763 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 205918006764 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 205918006765 dimer interface [polypeptide binding]; other site 205918006766 TPP-binding site [chemical binding]; other site 205918006767 Pirin-related protein [General function prediction only]; Region: COG1741 205918006768 Pirin; Region: Pirin; pfam02678 205918006769 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 205918006770 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 205918006771 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 205918006772 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 205918006773 active site 205918006774 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 205918006775 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006776 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006777 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006778 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918006779 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 205918006780 putative C-terminal domain interface [polypeptide binding]; other site 205918006781 putative GSH binding site (G-site) [chemical binding]; other site 205918006782 putative dimer interface [polypeptide binding]; other site 205918006783 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 205918006784 putative N-terminal domain interface [polypeptide binding]; other site 205918006785 putative dimer interface [polypeptide binding]; other site 205918006786 putative substrate binding pocket (H-site) [chemical binding]; other site 205918006787 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 205918006788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918006789 Walker A/P-loop; other site 205918006790 ATP binding site [chemical binding]; other site 205918006791 Q-loop/lid; other site 205918006792 ABC transporter signature motif; other site 205918006793 Walker B; other site 205918006794 D-loop; other site 205918006795 H-loop/switch region; other site 205918006796 inner membrane transport permease; Provisional; Region: PRK15066 205918006797 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 205918006798 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006799 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006800 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006801 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006802 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006803 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006804 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 205918006805 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 205918006806 Competence protein; Region: Competence; pfam03772 205918006807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 205918006808 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006809 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006810 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006811 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006812 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006813 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006814 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006815 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006816 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006817 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006818 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 205918006819 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006820 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006821 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006822 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918006823 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 205918006824 1 probable transmembrane helix predicted by TMHMM2.0 205918006825 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 205918006826 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 205918006827 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 205918006828 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 205918006829 Ligand binding site; other site 205918006830 oligomer interface; other site 205918006831 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 205918006832 FAD binding domain; Region: FAD_binding_4; pfam01565 205918006833 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 205918006834 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 205918006835 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 205918006836 homodimer interface [polypeptide binding]; other site 205918006837 oligonucleotide binding site [chemical binding]; other site 205918006838 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 205918006839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 205918006840 RNA binding surface [nucleotide binding]; other site 205918006841 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205918006842 active site 205918006843 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205918006844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918006845 motif II; other site 205918006846 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 205918006847 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 205918006848 tandem repeat interface [polypeptide binding]; other site 205918006849 oligomer interface [polypeptide binding]; other site 205918006850 active site residues [active] 205918006851 1 probable transmembrane helix predicted by TMHMM2.0 205918006852 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205918006853 active site 205918006854 dimer interface [polypeptide binding]; other site 205918006855 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 205918006856 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 205918006857 putative phosphate acyltransferase; Provisional; Region: PRK05331 205918006858 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 205918006859 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918006860 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918006861 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 205918006862 NAD(P) binding site [chemical binding]; other site 205918006863 homotetramer interface [polypeptide binding]; other site 205918006864 homodimer interface [polypeptide binding]; other site 205918006865 active site 205918006866 acyl carrier protein; Provisional; Region: acpP; PRK00982 205918006867 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 205918006868 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918006869 dimer interface [polypeptide binding]; other site 205918006870 active site 205918006871 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 205918006872 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 205918006873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006874 catalytic residue [active] 205918006875 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 205918006876 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 205918006877 dimerization interface [polypeptide binding]; other site 205918006878 thymidylate kinase; Validated; Region: tmk; PRK00698 205918006879 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 205918006880 TMP-binding site; other site 205918006881 ATP-binding site [chemical binding]; other site 205918006882 DNA polymerase III subunit delta'; Validated; Region: PRK05707 205918006883 AAA ATPase domain; Region: AAA_16; pfam13191 205918006884 DNA polymerase III subunit delta'; Validated; Region: PRK08485 205918006885 PilZ domain; Region: PilZ; cl01260 205918006886 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205918006887 active site 205918006888 LysE type translocator; Region: LysE; pfam01810 205918006889 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006890 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006891 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006892 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006893 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006894 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918006896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918006897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 205918006898 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 205918006899 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 205918006900 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205918006901 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918006902 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 205918006903 1 probable transmembrane helix predicted by TMHMM2.0 205918006904 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 205918006905 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 205918006906 dimerization interface 3.5A [polypeptide binding]; other site 205918006907 active site 205918006908 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 205918006909 active site 205918006910 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 205918006911 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 205918006912 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 205918006913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918006914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 205918006915 Sporulation related domain; Region: SPOR; pfam05036 205918006916 1 probable transmembrane helix predicted by TMHMM2.0 205918006917 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 205918006918 Colicin V production protein; Region: Colicin_V; cl00567 205918006919 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006920 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006921 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006922 amidophosphoribosyltransferase; Provisional; Region: PRK09246 205918006923 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 205918006924 active site 205918006925 tetramer interface [polypeptide binding]; other site 205918006926 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918006927 active site 205918006928 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 205918006929 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205918006930 homodimer interface [polypeptide binding]; other site 205918006931 substrate-cofactor binding pocket; other site 205918006932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006933 catalytic residue [active] 205918006934 oxidoreductase; Validated; Region: PRK05717 205918006935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918006936 NAD(P) binding site [chemical binding]; other site 205918006937 active site 205918006938 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 205918006939 threonine dehydratase; Reviewed; Region: PRK09224 205918006940 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 205918006941 tetramer interface [polypeptide binding]; other site 205918006942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006943 catalytic residue [active] 205918006944 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 205918006945 putative Ile/Val binding site [chemical binding]; other site 205918006946 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 205918006947 putative Ile/Val binding site [chemical binding]; other site 205918006948 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 205918006949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918006950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918006951 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 205918006952 active site 205918006953 catalytic triad [active] 205918006954 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918006955 dimer interface [polypeptide binding]; other site 205918006956 1 probable transmembrane helix predicted by TMHMM2.0 205918006957 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918006958 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 205918006959 active site 205918006960 FMN binding site [chemical binding]; other site 205918006961 2,4-decadienoyl-CoA binding site; other site 205918006962 catalytic residue [active] 205918006963 4Fe-4S cluster binding site [ion binding]; other site 205918006964 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 205918006965 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205918006966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006967 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918006968 putative substrate translocation pore; other site 205918006969 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006970 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006971 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006972 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006973 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006974 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006975 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006976 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006977 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006978 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006979 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006980 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006982 putative substrate translocation pore; other site 205918006983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918006984 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006985 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006986 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006987 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006988 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006989 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006990 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006991 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006992 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006993 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006994 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006995 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006996 arsenical pump membrane protein; Provisional; Region: PRK15445 205918006997 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 205918006998 transmembrane helices; other site 205918006999 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007000 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007001 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007002 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007003 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007004 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007005 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007006 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007007 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007008 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007009 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007010 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 205918007011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918007012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918007013 metal binding site [ion binding]; metal-binding site 205918007014 active site 205918007015 I-site; other site 205918007016 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007017 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007018 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007019 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007020 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007021 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007022 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 205918007023 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 205918007024 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918007025 active site 205918007026 metal binding site [ion binding]; metal-binding site 205918007027 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 205918007028 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 205918007029 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007030 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007031 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007032 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007033 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007034 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007035 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 205918007036 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 205918007037 aminopeptidase N; Provisional; Region: pepN; PRK14015 205918007038 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 205918007039 active site 205918007040 Zn binding site [ion binding]; other site 205918007041 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 205918007042 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 205918007043 Rhomboid family; Region: Rhomboid; cl11446 205918007044 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007045 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007046 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007047 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007048 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007049 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007050 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 205918007051 Predicted membrane protein [Function unknown]; Region: COG3766 205918007052 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 205918007053 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007054 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007055 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007056 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007057 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 205918007058 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 205918007059 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 205918007060 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 205918007061 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 205918007062 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007063 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007064 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007065 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007066 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007067 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007068 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007069 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007070 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007071 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007072 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007073 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918007075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918007076 DNA binding residues [nucleotide binding] 205918007077 dimerization interface [polypeptide binding]; other site 205918007078 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918007079 Fatty acid desaturase; Region: FA_desaturase; pfam00487 205918007080 putative di-iron ligands [ion binding]; other site 205918007081 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918007082 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007083 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007084 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007085 Condensation domain; Region: Condensation; pfam00668 205918007086 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007087 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007088 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918007089 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918007090 acyl-activating enzyme (AAE) consensus motif; other site 205918007091 AMP binding site [chemical binding]; other site 205918007092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007093 Condensation domain; Region: Condensation; pfam00668 205918007094 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007095 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007096 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918007097 acyl-activating enzyme (AAE) consensus motif; other site 205918007098 AMP binding site [chemical binding]; other site 205918007099 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007100 Condensation domain; Region: Condensation; pfam00668 205918007101 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007102 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007103 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918007104 acyl-activating enzyme (AAE) consensus motif; other site 205918007105 AMP binding site [chemical binding]; other site 205918007106 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007107 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 205918007108 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918007109 active site 205918007110 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 205918007111 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 205918007112 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918007113 KR domain; Region: KR; pfam08659 205918007114 putative NADP binding site [chemical binding]; other site 205918007115 active site 205918007116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007117 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918007118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918007120 putative substrate translocation pore; other site 205918007121 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007122 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007123 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007124 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007125 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007126 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007127 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007128 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007129 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007130 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007131 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918007132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918007133 DNA-binding site [nucleotide binding]; DNA binding site 205918007134 FCD domain; Region: FCD; pfam07729 205918007135 dihydroxy-acid dehydratase; Validated; Region: PRK06131 205918007136 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 205918007137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007138 putative substrate translocation pore; other site 205918007139 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007140 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007141 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007142 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007143 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007144 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007145 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007146 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007147 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007148 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007149 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007150 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 205918007152 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 205918007153 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 205918007154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918007155 AAA domain; Region: AAA_23; pfam13476 205918007156 Walker A/P-loop; other site 205918007157 ATP binding site [chemical binding]; other site 205918007158 Q-loop/lid; other site 205918007159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918007160 ABC transporter signature motif; other site 205918007161 Walker B; other site 205918007162 D-loop; other site 205918007163 H-loop/switch region; other site 205918007164 exonuclease subunit SbcD; Provisional; Region: PRK10966 205918007165 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 205918007166 active site 205918007167 metal binding site [ion binding]; metal-binding site 205918007168 DNA binding site [nucleotide binding] 205918007169 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 205918007170 Oxygen tolerance; Region: BatD; pfam13584 205918007171 1 probable transmembrane helix predicted by TMHMM2.0 205918007172 von Willebrand factor type A domain; Region: VWA_2; pfam13519 205918007173 metal ion-dependent adhesion site (MIDAS); other site 205918007174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918007175 TPR motif; other site 205918007176 binding surface 205918007177 TPR repeat; Region: TPR_11; pfam13414 205918007178 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007179 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007180 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 205918007181 metal ion-dependent adhesion site (MIDAS); other site 205918007182 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 205918007183 1 probable transmembrane helix predicted by TMHMM2.0 205918007184 Protein of unknown function DUF58; Region: DUF58; pfam01882 205918007185 MoxR-like ATPases [General function prediction only]; Region: COG0714 205918007186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007187 Walker A motif; other site 205918007188 ATP binding site [chemical binding]; other site 205918007189 Walker B motif; other site 205918007190 arginine finger; other site 205918007191 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 205918007192 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918007193 active site 205918007194 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 205918007195 hypothetical protein; Provisional; Region: PRK11469 205918007196 Domain of unknown function DUF; Region: DUF204; pfam02659 205918007197 Domain of unknown function DUF; Region: DUF204; pfam02659 205918007198 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007199 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007200 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007201 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007202 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007203 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 205918007204 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 205918007205 substrate binding site [chemical binding]; other site 205918007206 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 205918007207 substrate binding site [chemical binding]; other site 205918007208 ligand binding site [chemical binding]; other site 205918007209 Predicted Fe-S protein [General function prediction only]; Region: COG3313 205918007210 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 205918007211 active site 205918007212 dinuclear metal binding site [ion binding]; other site 205918007213 dimerization interface [polypeptide binding]; other site 205918007214 MarR family; Region: MarR_2; cl17246 205918007215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918007216 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 205918007217 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918007218 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918007219 1 probable transmembrane helix predicted by TMHMM2.0 205918007220 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918007221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007222 putative substrate translocation pore; other site 205918007223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007224 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007225 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007226 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007227 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007228 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007229 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007230 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007231 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007232 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007233 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007234 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007235 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007236 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007237 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007238 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918007239 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 205918007240 putative active site [active] 205918007241 putative metal binding site [ion binding]; other site 205918007242 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 205918007243 substrate binding site [chemical binding]; other site 205918007244 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 205918007245 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918007246 active site 205918007247 HIGH motif; other site 205918007248 nucleotide binding site [chemical binding]; other site 205918007249 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 205918007250 KMSKS motif; other site 205918007251 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 205918007252 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 205918007253 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205918007254 active site 205918007255 HIGH motif; other site 205918007256 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205918007257 KMSKS motif; other site 205918007258 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 205918007259 tRNA binding surface [nucleotide binding]; other site 205918007260 anticodon binding site; other site 205918007261 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 205918007262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007263 Walker A motif; other site 205918007264 ATP binding site [chemical binding]; other site 205918007265 Walker B motif; other site 205918007266 arginine finger; other site 205918007267 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 205918007268 DNA-binding interface [nucleotide binding]; DNA binding site 205918007269 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 205918007270 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 205918007271 Walker A/P-loop; other site 205918007272 ATP binding site [chemical binding]; other site 205918007273 Q-loop/lid; other site 205918007274 ABC transporter signature motif; other site 205918007275 Walker B; other site 205918007276 D-loop; other site 205918007277 H-loop/switch region; other site 205918007278 TOBE domain; Region: TOBE_2; pfam08402 205918007279 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 205918007280 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 205918007281 Walker A/P-loop; other site 205918007282 ATP binding site [chemical binding]; other site 205918007283 Q-loop/lid; other site 205918007284 ABC transporter signature motif; other site 205918007285 Walker B; other site 205918007286 D-loop; other site 205918007287 H-loop/switch region; other site 205918007288 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205918007289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007290 dimer interface [polypeptide binding]; other site 205918007291 conserved gate region; other site 205918007292 putative PBP binding loops; other site 205918007293 ABC-ATPase subunit interface; other site 205918007294 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007295 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007296 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007297 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007298 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007299 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007302 dimer interface [polypeptide binding]; other site 205918007303 conserved gate region; other site 205918007304 putative PBP binding loops; other site 205918007305 ABC-ATPase subunit interface; other site 205918007306 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007307 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007308 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007309 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007310 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007311 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007312 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 205918007313 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007314 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007315 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007316 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918007317 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 205918007318 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205918007319 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205918007320 homodimer interface [polypeptide binding]; other site 205918007321 NADP binding site [chemical binding]; other site 205918007322 substrate binding site [chemical binding]; other site 205918007323 trigger factor; Provisional; Region: tig; PRK01490 205918007324 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918007325 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 205918007326 1 probable transmembrane helix predicted by TMHMM2.0 205918007327 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 205918007328 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205918007329 oligomer interface [polypeptide binding]; other site 205918007330 active site residues [active] 205918007331 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 205918007332 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 205918007333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007334 Walker A motif; other site 205918007335 ATP binding site [chemical binding]; other site 205918007336 Walker B motif; other site 205918007337 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 205918007338 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 205918007339 Found in ATP-dependent protease La (LON); Region: LON; smart00464 205918007340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007341 Walker A motif; other site 205918007342 ATP binding site [chemical binding]; other site 205918007343 Walker B motif; other site 205918007344 arginine finger; other site 205918007345 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205918007346 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918007347 IHF - DNA interface [nucleotide binding]; other site 205918007348 IHF dimer interface [polypeptide binding]; other site 205918007349 periplasmic folding chaperone; Provisional; Region: PRK10788 205918007350 SurA N-terminal domain; Region: SurA_N_3; pfam13624 205918007351 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 205918007352 1 probable transmembrane helix predicted by TMHMM2.0 205918007353 Predicted transcriptional regulators [Transcription]; Region: COG1733 205918007354 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 205918007355 SnoaL-like domain; Region: SnoaL_2; pfam12680 205918007356 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 205918007357 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 205918007358 NAD binding site [chemical binding]; other site 205918007359 homotetramer interface [polypeptide binding]; other site 205918007360 homodimer interface [polypeptide binding]; other site 205918007361 substrate binding site [chemical binding]; other site 205918007362 active site 205918007363 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 205918007364 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918007365 Walker A/P-loop; other site 205918007366 ATP binding site [chemical binding]; other site 205918007367 Q-loop/lid; other site 205918007368 ABC transporter signature motif; other site 205918007369 Walker B; other site 205918007370 D-loop; other site 205918007371 H-loop/switch region; other site 205918007372 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 205918007373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918007374 Walker A/P-loop; other site 205918007375 ATP binding site [chemical binding]; other site 205918007376 Q-loop/lid; other site 205918007377 ABC transporter signature motif; other site 205918007378 Walker B; other site 205918007379 D-loop; other site 205918007380 H-loop/switch region; other site 205918007381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918007382 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918007383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007384 dimer interface [polypeptide binding]; other site 205918007385 conserved gate region; other site 205918007386 putative PBP binding loops; other site 205918007387 ABC-ATPase subunit interface; other site 205918007388 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007389 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007390 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007391 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007392 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007393 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007394 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 205918007395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007396 dimer interface [polypeptide binding]; other site 205918007397 conserved gate region; other site 205918007398 putative PBP binding loops; other site 205918007399 ABC-ATPase subunit interface; other site 205918007400 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007401 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007402 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007403 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007404 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007405 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007406 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918007407 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918007408 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918007409 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918007410 MltD lipid attachment motif; Region: MLTD_N; pfam06474 205918007411 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 205918007412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918007413 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918007414 catalytic residue [active] 205918007415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918007416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918007417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918007418 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 205918007419 Methyltransferase domain; Region: Methyltransf_23; pfam13489 205918007420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205918007421 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 205918007422 RNA/DNA hybrid binding site [nucleotide binding]; other site 205918007423 active site 205918007424 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 205918007425 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 205918007426 active site 205918007427 catalytic site [active] 205918007428 substrate binding site [chemical binding]; other site 205918007429 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918007430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918007431 Coenzyme A binding pocket [chemical binding]; other site 205918007432 Predicted flavoprotein [General function prediction only]; Region: COG0431 205918007433 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918007434 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918007435 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918007436 active site 205918007437 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 205918007438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918007439 substrate binding site [chemical binding]; other site 205918007440 oxyanion hole (OAH) forming residues; other site 205918007441 trimer interface [polypeptide binding]; other site 205918007442 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 205918007443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007444 putative substrate translocation pore; other site 205918007445 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918007446 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007447 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007448 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007449 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007450 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007451 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007452 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007453 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007454 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007455 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007456 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007457 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007458 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007459 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007460 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 205918007461 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918007462 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918007463 1 probable transmembrane helix predicted by TMHMM2.0 205918007464 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 205918007465 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 205918007466 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007467 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007468 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007469 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007470 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007471 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007472 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007473 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007474 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007475 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 205918007476 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 205918007477 Cl binding site [ion binding]; other site 205918007478 oligomer interface [polypeptide binding]; other site 205918007479 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007480 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918007482 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918007483 active site 205918007484 catalytic tetrad [active] 205918007485 Cache domain; Region: Cache_2; pfam08269 205918007486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918007487 dimerization interface [polypeptide binding]; other site 205918007488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918007489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918007490 dimer interface [polypeptide binding]; other site 205918007491 putative CheW interface [polypeptide binding]; other site 205918007492 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007493 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007494 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007495 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 205918007496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918007497 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 205918007498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918007499 PAS domain; Region: PAS_9; pfam13426 205918007500 putative active site [active] 205918007501 heme pocket [chemical binding]; other site 205918007502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918007503 PAS fold; Region: PAS_3; pfam08447 205918007504 putative active site [active] 205918007505 heme pocket [chemical binding]; other site 205918007506 PAS domain S-box; Region: sensory_box; TIGR00229 205918007507 PAS domain; Region: PAS_8; pfam13188 205918007508 PAS fold; Region: PAS_3; pfam08447 205918007509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918007510 dimer interface [polypeptide binding]; other site 205918007511 phosphorylation site [posttranslational modification] 205918007512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918007513 ATP binding site [chemical binding]; other site 205918007514 Mg2+ binding site [ion binding]; other site 205918007515 G-X-G motif; other site 205918007516 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918007517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918007518 active site 205918007519 phosphorylation site [posttranslational modification] 205918007520 intermolecular recognition site; other site 205918007521 dimerization interface [polypeptide binding]; other site 205918007522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918007523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918007524 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 205918007525 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 205918007526 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 205918007527 PA14 domain; Region: PA14; pfam07691 205918007528 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 205918007529 1 probable transmembrane helix predicted by TMHMM2.0 205918007530 hypothetical protein 205918007531 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 205918007532 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918007533 N-terminal plug; other site 205918007534 ligand-binding site [chemical binding]; other site 205918007535 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 205918007536 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 205918007537 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007538 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007539 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007540 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007541 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 205918007542 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205918007543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007544 putative substrate translocation pore; other site 205918007545 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007546 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007547 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007548 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007549 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007550 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007551 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007552 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007553 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007554 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007555 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007556 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007557 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918007558 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918007559 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918007560 dimer interface [polypeptide binding]; other site 205918007561 putative CheW interface [polypeptide binding]; other site 205918007562 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007563 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007564 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918007565 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918007566 active site 205918007567 catalytic tetrad [active] 205918007568 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 205918007569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918007570 motif II; other site 205918007571 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918007572 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918007573 acyl-activating enzyme (AAE) consensus motif; other site 205918007574 AMP binding site [chemical binding]; other site 205918007575 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007576 Condensation domain; Region: Condensation; pfam00668 205918007577 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007578 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007579 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918007580 acyl-activating enzyme (AAE) consensus motif; other site 205918007581 AMP binding site [chemical binding]; other site 205918007582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007583 Condensation domain; Region: Condensation; pfam00668 205918007584 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007585 Nonribosomal peptide synthase; Region: NRPS; pfam08415 205918007586 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 205918007587 acyl-activating enzyme (AAE) consensus motif; other site 205918007588 AMP binding site [chemical binding]; other site 205918007589 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007590 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 205918007591 putative FMN binding site [chemical binding]; other site 205918007592 NADPH bind site [chemical binding]; other site 205918007593 Condensation domain; Region: Condensation; pfam00668 205918007594 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007595 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007596 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918007597 acyl-activating enzyme (AAE) consensus motif; other site 205918007598 AMP binding site [chemical binding]; other site 205918007599 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007600 Thioesterase domain; Region: Thioesterase; pfam00975 205918007601 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918007602 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918007603 acyl-activating enzyme (AAE) consensus motif; other site 205918007604 AMP binding site [chemical binding]; other site 205918007605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007606 Condensation domain; Region: Condensation; pfam00668 205918007607 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918007609 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918007610 acyl-activating enzyme (AAE) consensus motif; other site 205918007611 AMP binding site [chemical binding]; other site 205918007612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007613 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918007614 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918007615 active site 205918007616 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918007617 putative NADP binding site [chemical binding]; other site 205918007618 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 205918007619 active site 205918007620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918007621 Thioesterase domain; Region: Thioesterase; pfam00975 205918007622 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918007623 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918007624 active site 205918007625 iron coordination sites [ion binding]; other site 205918007626 substrate binding pocket [chemical binding]; other site 205918007627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918007628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918007629 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 205918007630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918007631 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918007632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918007633 dimerization interface [polypeptide binding]; other site 205918007634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918007635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918007636 dimer interface [polypeptide binding]; other site 205918007637 putative CheW interface [polypeptide binding]; other site 205918007638 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007639 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007640 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 205918007641 EamA-like transporter family; Region: EamA; pfam00892 205918007642 EamA-like transporter family; Region: EamA; pfam00892 205918007643 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007644 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007645 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007646 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007647 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007648 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007649 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007650 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007651 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918007653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918007654 LysR substrate binding domain; Region: LysR_substrate; pfam03466 205918007655 dimerization interface [polypeptide binding]; other site 205918007656 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 205918007657 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 205918007658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918007659 catalytic residue [active] 205918007660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918007661 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 205918007662 putative DNA binding site [nucleotide binding]; other site 205918007663 putative Zn2+ binding site [ion binding]; other site 205918007664 AsnC family; Region: AsnC_trans_reg; pfam01037 205918007665 Protein of unknown function (DUF808); Region: DUF808; pfam05661 205918007666 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007667 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007668 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007669 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007670 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007671 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007672 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 205918007673 Predicted membrane protein [Function unknown]; Region: COG3748 205918007674 Protein of unknown function (DUF989); Region: DUF989; pfam06181 205918007675 Cytochrome c; Region: Cytochrom_C; pfam00034 205918007676 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007677 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007678 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007679 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007680 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007681 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007682 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007683 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007684 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 205918007685 ureidoglycolate hydrolase; Provisional; Region: PRK03606 205918007686 allantoicase; Provisional; Region: PRK13257 205918007687 Allantoicase repeat; Region: Allantoicase; pfam03561 205918007688 Allantoicase repeat; Region: Allantoicase; pfam03561 205918007689 OHCU decarboxylase; Region: UHCUDC; TIGR03164 205918007690 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 205918007691 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 205918007692 active site 205918007693 catalytic site [active] 205918007694 tetramer interface [polypeptide binding]; other site 205918007695 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 205918007696 active site 205918007697 homotetramer interface [polypeptide binding]; other site 205918007698 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918007699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918007700 DNA-binding site [nucleotide binding]; DNA binding site 205918007701 FCD domain; Region: FCD; pfam07729 205918007702 guanine deaminase; Provisional; Region: PRK09228 205918007703 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 205918007704 active site 205918007705 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 205918007706 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 205918007707 XdhC Rossmann domain; Region: XdhC_C; pfam13478 205918007708 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 205918007709 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 205918007710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 205918007711 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 205918007712 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918007713 catalytic loop [active] 205918007714 iron binding site [ion binding]; other site 205918007715 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 205918007716 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 205918007717 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918007718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918007719 DNA-binding site [nucleotide binding]; DNA binding site 205918007720 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918007721 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 205918007722 Walker A/P-loop; other site 205918007723 ATP binding site [chemical binding]; other site 205918007724 Q-loop/lid; other site 205918007725 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 205918007726 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 205918007727 ABC transporter signature motif; other site 205918007728 Walker B; other site 205918007729 D-loop; other site 205918007730 H-loop/switch region; other site 205918007731 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 205918007732 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 205918007733 FtsZ protein binding site [polypeptide binding]; other site 205918007734 1 probable transmembrane helix predicted by TMHMM2.0 205918007735 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 205918007736 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 205918007737 nucleotide binding pocket [chemical binding]; other site 205918007738 K-X-D-G motif; other site 205918007739 catalytic site [active] 205918007740 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205918007741 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 205918007742 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 205918007743 Dimer interface [polypeptide binding]; other site 205918007744 BRCT sequence motif; other site 205918007745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 205918007746 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 205918007747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918007748 Coenzyme A binding pocket [chemical binding]; other site 205918007749 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205918007750 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918007751 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007752 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007753 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007754 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007755 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007756 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 205918007757 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 205918007758 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 205918007759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918007760 substrate binding pocket [chemical binding]; other site 205918007761 membrane-bound complex binding site; other site 205918007762 hinge residues; other site 205918007763 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 205918007764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007765 Walker A motif; other site 205918007766 ATP binding site [chemical binding]; other site 205918007767 Walker B motif; other site 205918007768 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 205918007769 arginine finger; other site 205918007770 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 205918007771 hypothetical protein; Validated; Region: PRK00153 205918007772 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 205918007773 CPxP motif; other site 205918007774 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 205918007775 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 205918007776 ligand binding site [chemical binding]; other site 205918007777 NAD binding site [chemical binding]; other site 205918007778 catalytic site [active] 205918007779 homodimer interface [polypeptide binding]; other site 205918007780 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 205918007781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918007782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918007783 Walker A/P-loop; other site 205918007784 ATP binding site [chemical binding]; other site 205918007785 Q-loop/lid; other site 205918007786 ABC transporter signature motif; other site 205918007787 Walker B; other site 205918007788 D-loop; other site 205918007789 H-loop/switch region; other site 205918007790 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007791 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007792 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007793 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007794 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007795 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007796 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 205918007797 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 205918007798 active site 205918007799 catalytic site [active] 205918007800 substrate binding site [chemical binding]; other site 205918007801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918007802 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918007803 substrate binding pocket [chemical binding]; other site 205918007804 membrane-bound complex binding site; other site 205918007805 hinge residues; other site 205918007806 1 probable transmembrane helix predicted by TMHMM2.0 205918007807 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 205918007808 1 probable transmembrane helix predicted by TMHMM2.0 205918007809 ethanolamine permease; Region: 2A0305; TIGR00908 205918007810 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007811 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007812 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007813 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007814 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007815 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007816 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007817 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007818 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007819 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007820 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007821 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007822 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 205918007823 active site 205918007824 dimer interface [polypeptide binding]; other site 205918007825 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 205918007826 Prostaglandin dehydrogenases; Region: PGDH; cd05288 205918007827 NAD(P) binding site [chemical binding]; other site 205918007828 substrate binding site [chemical binding]; other site 205918007829 dimer interface [polypeptide binding]; other site 205918007830 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 205918007831 dimer interface [polypeptide binding]; other site 205918007832 catalytic triad [active] 205918007833 Benzoate membrane transport protein; Region: BenE; pfam03594 205918007834 benzoate transporter; Region: benE; TIGR00843 205918007835 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007836 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007837 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007838 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007839 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007840 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007841 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007842 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007843 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007844 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007845 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007846 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007847 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918007848 MarR family; Region: MarR_2; pfam12802 205918007849 aspartate aminotransferase; Provisional; Region: PRK05764 205918007850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918007851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918007852 homodimer interface [polypeptide binding]; other site 205918007853 catalytic residue [active] 205918007854 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918007855 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 205918007856 putative C-terminal domain interface [polypeptide binding]; other site 205918007857 putative GSH binding site (G-site) [chemical binding]; other site 205918007858 putative dimer interface [polypeptide binding]; other site 205918007859 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 205918007860 N-terminal domain interface [polypeptide binding]; other site 205918007861 dimer interface [polypeptide binding]; other site 205918007862 substrate binding pocket (H-site) [chemical binding]; other site 205918007863 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 205918007864 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918007865 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 205918007866 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 205918007867 GTP cyclohydrolase I; Provisional; Region: PLN03044 205918007868 homodecamer interface [polypeptide binding]; other site 205918007869 active site 205918007870 putative catalytic site residues [active] 205918007871 zinc binding site [ion binding]; other site 205918007872 GTP-CH-I/GFRP interaction surface; other site 205918007873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 205918007874 Smr domain; Region: Smr; pfam01713 205918007875 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007876 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007877 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 205918007878 Isochorismatase family; Region: Isochorismatase; pfam00857 205918007879 catalytic triad [active] 205918007880 conserved cis-peptide bond; other site 205918007881 HemK family putative methylases; Region: hemK_fam; TIGR00536 205918007882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918007883 S-adenosylmethionine binding site [chemical binding]; other site 205918007884 1 probable transmembrane helix predicted by TMHMM2.0 205918007885 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 205918007886 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 205918007887 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 205918007888 Tetramer interface [polypeptide binding]; other site 205918007889 active site 205918007890 FMN-binding site [chemical binding]; other site 205918007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007892 putative substrate translocation pore; other site 205918007893 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007894 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007895 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007896 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007897 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007898 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007899 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007900 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007901 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007902 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007903 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007904 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 205918007905 intersubunit interface [polypeptide binding]; other site 205918007906 active site 205918007907 Zn2+ binding site [ion binding]; other site 205918007908 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 205918007909 Cupin domain; Region: Cupin_2; cl17218 205918007910 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 205918007911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918007912 motif II; other site 205918007913 Autoinducer binding domain; Region: Autoind_bind; pfam03472 205918007914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918007915 DNA binding residues [nucleotide binding] 205918007916 dimerization interface [polypeptide binding]; other site 205918007917 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 205918007918 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205918007919 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205918007920 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205918007921 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 205918007922 ZIP Zinc transporter; Region: Zip; pfam02535 205918007923 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007924 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007925 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007926 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007927 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007928 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007929 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007930 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007931 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007932 spermidine synthase; Provisional; Region: PRK00811 205918007933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918007934 S-adenosylmethionine binding site [chemical binding]; other site 205918007935 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 205918007936 Sulfatase; Region: Sulfatase; pfam00884 205918007937 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007938 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007939 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007940 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007941 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007942 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 205918007943 Uncharacterized conserved protein [Function unknown]; Region: COG2308 205918007944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 205918007945 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 205918007946 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205918007947 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205918007948 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 205918007949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 205918007950 active site residue [active] 205918007951 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 205918007952 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 205918007953 catalytic triad [active] 205918007954 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 205918007955 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 205918007956 oligomer interface [polypeptide binding]; other site 205918007957 metal binding site [ion binding]; metal-binding site 205918007958 metal binding site [ion binding]; metal-binding site 205918007959 putative Cl binding site [ion binding]; other site 205918007960 basic sphincter; other site 205918007961 hydrophobic gate; other site 205918007962 periplasmic entrance; other site 205918007963 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007964 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007965 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918007966 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 205918007967 substrate binding site [chemical binding]; other site 205918007968 oxyanion hole (OAH) forming residues; other site 205918007969 trimer interface [polypeptide binding]; other site 205918007970 conserved hypothetical protein; Region: TIGR02118 205918007971 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918007972 Cytochrome c; Region: Cytochrom_C; cl11414 205918007973 Cupin domain; Region: Cupin_2; cl17218 205918007974 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 205918007975 Peptidase S24, S26A and S26B 205918007976 Y-family of DNA polymerases; Region: PolY; cl12025 205918007977 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918007978 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918007979 hypothetical protein 205918007980 Phage integrase 205918007981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918007982 classical (c) SDRs; Region: SDR_c; cd05233 205918007983 NAD(P) binding site [chemical binding]; other site 205918007984 active site 205918007985 Isochorismatase family; Region: Isochorismatase; pfam00857 205918007986 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 205918007987 catalytic triad [active] 205918007988 conserved cis-peptide bond; other site 205918007989 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 205918007990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918007991 ATP binding site [chemical binding]; other site 205918007992 putative Mg++ binding site [ion binding]; other site 205918007993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918007994 nucleotide binding region [chemical binding]; other site 205918007995 ATP-binding site [chemical binding]; other site 205918007996 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 205918007997 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 205918007998 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 205918007999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918008000 ATP binding site [chemical binding]; other site 205918008001 putative Mg++ binding site [ion binding]; other site 205918008002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918008003 nucleotide binding region [chemical binding]; other site 205918008004 ATP-binding site [chemical binding]; other site 205918008005 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 205918008006 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 205918008007 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 205918008008 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205918008009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918008011 putative substrate translocation pore; other site 205918008012 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008013 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008014 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008015 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008016 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008017 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008018 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008019 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008020 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008021 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008022 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918008023 citrate-proton symporter; Provisional; Region: PRK15075 205918008024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008025 putative substrate translocation pore; other site 205918008026 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008027 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008028 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008029 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008030 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008031 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008032 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008033 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008034 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008035 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008036 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 205918008037 ApbE family; Region: ApbE; pfam02424 205918008038 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 205918008039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918008040 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205918008041 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 205918008042 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 205918008043 active site 205918008044 catalytic site [active] 205918008045 metal binding site [ion binding]; metal-binding site 205918008046 PilZ domain; Region: PilZ; pfam07238 205918008047 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 205918008048 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918008049 FtsX-like permease family; Region: FtsX; pfam02687 205918008050 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008051 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008052 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008053 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008054 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 205918008055 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205918008056 Walker A/P-loop; other site 205918008057 ATP binding site [chemical binding]; other site 205918008058 Q-loop/lid; other site 205918008059 ABC transporter signature motif; other site 205918008060 Walker B; other site 205918008061 D-loop; other site 205918008062 H-loop/switch region; other site 205918008063 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 205918008064 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918008065 FtsX-like permease family; Region: FtsX; pfam02687 205918008066 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008067 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008068 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008069 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 205918008071 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 205918008072 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 205918008073 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 205918008074 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 205918008075 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 205918008076 PilZ domain; Region: PilZ; pfam07238 205918008077 Response regulator receiver domain; Region: Response_reg; pfam00072 205918008078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008079 active site 205918008080 phosphorylation site [posttranslational modification] 205918008081 intermolecular recognition site; other site 205918008082 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 205918008083 dimerization interface [polypeptide binding]; other site 205918008084 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 205918008085 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918008086 anti sigma factor interaction site; other site 205918008087 regulatory phosphorylation site [posttranslational modification]; other site 205918008088 transaldolase-like protein; Provisional; Region: PTZ00411 205918008089 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 205918008090 active site 205918008091 dimer interface [polypeptide binding]; other site 205918008092 catalytic residue [active] 205918008093 glutamate carboxypeptidase; Reviewed; Region: PRK06133 205918008094 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 205918008095 metal binding site [ion binding]; metal-binding site 205918008096 dimer interface [polypeptide binding]; other site 205918008097 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918008098 Catalytic site [active] 205918008099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918008100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008101 dimer interface [polypeptide binding]; other site 205918008102 phosphorylation site [posttranslational modification] 205918008103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008104 ATP binding site [chemical binding]; other site 205918008105 Mg2+ binding site [ion binding]; other site 205918008106 G-X-G motif; other site 205918008107 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 205918008108 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918008109 tetramer interface [polypeptide binding]; other site 205918008110 active site 205918008111 Mg2+/Mn2+ binding site [ion binding]; other site 205918008112 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 205918008113 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 205918008114 ATP binding site [chemical binding]; other site 205918008115 substrate interface [chemical binding]; other site 205918008116 1 probable transmembrane helix predicted by TMHMM2.0 205918008117 H+ Antiporter protein; Region: 2A0121; TIGR00900 205918008118 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008119 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008120 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008121 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008122 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008123 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008124 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008125 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008126 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008127 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008128 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008129 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 205918008131 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 205918008132 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918008133 inhibitor-cofactor binding pocket; inhibition site 205918008134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918008135 catalytic residue [active] 205918008136 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 205918008137 Cupin domain; Region: Cupin_2; pfam07883 205918008138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918008139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918008140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918008141 dimerization interface [polypeptide binding]; other site 205918008142 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 205918008143 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 205918008144 conserved hypothetical protein 205918008145 Protein of unknown function (DUF796); Region: DUF796; pfam05638 205918008146 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 205918008147 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205918008148 FMN binding site [chemical binding]; other site 205918008149 active site 205918008150 catalytic residues [active] 205918008151 substrate binding site [chemical binding]; other site 205918008152 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205918008153 Ligand Binding Site [chemical binding]; other site 205918008154 Response regulator receiver domain; Region: Response_reg; pfam00072 205918008155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008156 active site 205918008157 phosphorylation site [posttranslational modification] 205918008158 intermolecular recognition site; other site 205918008159 dimerization interface [polypeptide binding]; other site 205918008160 CHASE3 domain; Region: CHASE3; pfam05227 205918008161 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205918008162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008163 putative active site [active] 205918008164 heme pocket [chemical binding]; other site 205918008165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008166 dimer interface [polypeptide binding]; other site 205918008167 phosphorylation site [posttranslational modification] 205918008168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008169 ATP binding site [chemical binding]; other site 205918008170 Mg2+ binding site [ion binding]; other site 205918008171 G-X-G motif; other site 205918008172 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918008173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008174 active site 205918008175 phosphorylation site [posttranslational modification] 205918008176 intermolecular recognition site; other site 205918008177 dimerization interface [polypeptide binding]; other site 205918008178 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008179 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918008181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008182 active site 205918008183 phosphorylation site [posttranslational modification] 205918008184 intermolecular recognition site; other site 205918008185 dimerization interface [polypeptide binding]; other site 205918008186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918008187 DNA binding residues [nucleotide binding] 205918008188 dimerization interface [polypeptide binding]; other site 205918008189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205918008190 Histidine kinase; Region: HisKA_3; pfam07730 205918008191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008192 ATP binding site [chemical binding]; other site 205918008193 Mg2+ binding site [ion binding]; other site 205918008194 G-X-G motif; other site 205918008195 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 205918008196 SnoaL-like domain; Region: SnoaL_3; pfam13474 205918008197 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 205918008198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918008199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918008200 DNA binding residues [nucleotide binding] 205918008201 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 205918008202 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 205918008203 nucleophilic elbow; other site 205918008204 catalytic triad; other site 205918008205 peptide synthase; Validated; Region: PRK05691 205918008206 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 205918008207 acyl-activating enzyme (AAE) consensus motif; other site 205918008208 active site 205918008209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008210 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008211 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008212 acyl-activating enzyme (AAE) consensus motif; other site 205918008213 AMP binding site [chemical binding]; other site 205918008214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008215 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008216 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008217 acyl-activating enzyme (AAE) consensus motif; other site 205918008218 AMP binding site [chemical binding]; other site 205918008219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008220 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 205918008221 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008222 acyl-activating enzyme (AAE) consensus motif; other site 205918008223 AMP binding site [chemical binding]; other site 205918008224 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008225 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 205918008226 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918008227 inhibitor-cofactor binding pocket; inhibition site 205918008228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918008229 catalytic residue [active] 205918008230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 205918008231 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205918008232 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 205918008233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918008234 ABC-ATPase subunit interface; other site 205918008235 dimer interface [polypeptide binding]; other site 205918008236 putative PBP binding regions; other site 205918008237 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008238 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008239 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008240 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008241 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008242 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008243 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008244 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918008245 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205918008246 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 205918008247 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 205918008248 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 205918008249 metal binding site [ion binding]; metal-binding site 205918008250 1 probable transmembrane helix predicted by TMHMM2.0 205918008251 1 probable transmembrane helix predicted by TMHMM2.0 205918008252 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918008253 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 205918008254 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 205918008255 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 205918008256 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 205918008257 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008258 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008259 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008260 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008261 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 205918008262 Condensation domain; Region: Condensation; pfam00668 205918008263 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008264 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008265 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008266 acyl-activating enzyme (AAE) consensus motif; other site 205918008267 AMP binding site [chemical binding]; other site 205918008268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008269 Condensation domain; Region: Condensation; pfam00668 205918008270 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008271 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008272 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918008273 acyl-activating enzyme (AAE) consensus motif; other site 205918008274 AMP binding site [chemical binding]; other site 205918008275 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008276 Condensation domain; Region: Condensation; pfam00668 205918008277 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008278 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 205918008279 Condensation domain; Region: Condensation; pfam00668 205918008280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008281 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008282 acyl-activating enzyme (AAE) consensus motif; other site 205918008283 AMP binding site [chemical binding]; other site 205918008284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008285 Condensation domain; Region: Condensation; pfam00668 205918008286 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008287 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008288 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008289 acyl-activating enzyme (AAE) consensus motif; other site 205918008290 AMP binding site [chemical binding]; other site 205918008291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008292 Condensation domain; Region: Condensation; pfam00668 205918008293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008294 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008295 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008296 acyl-activating enzyme (AAE) consensus motif; other site 205918008297 AMP binding site [chemical binding]; other site 205918008298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008299 Condensation domain; Region: Condensation; pfam00668 205918008300 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008301 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008302 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008303 acyl-activating enzyme (AAE) consensus motif; other site 205918008304 AMP binding site [chemical binding]; other site 205918008305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008306 Condensation domain; Region: Condensation; pfam00668 205918008307 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008308 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 205918008309 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 205918008310 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918008311 acyl-activating enzyme (AAE) consensus motif; other site 205918008312 AMP binding site [chemical binding]; other site 205918008313 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918008314 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 205918008315 Secretin and TonB N terminus short domain; Region: STN; smart00965 205918008316 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918008317 N-terminal plug; other site 205918008318 ligand-binding site [chemical binding]; other site 205918008319 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 205918008320 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918008321 N-terminal plug; other site 205918008322 ligand-binding site [chemical binding]; other site 205918008323 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 205918008324 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918008325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918008326 Walker A/P-loop; other site 205918008327 ATP binding site [chemical binding]; other site 205918008328 Q-loop/lid; other site 205918008329 ABC transporter signature motif; other site 205918008330 Walker B; other site 205918008331 D-loop; other site 205918008332 H-loop/switch region; other site 205918008333 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008334 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008335 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008336 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008337 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008338 Uncharacterized conserved protein [Function unknown]; Region: COG1262 205918008339 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 205918008340 1 probable transmembrane helix predicted by TMHMM2.0 205918008341 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 205918008342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918008343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918008344 catalytic residue [active] 205918008345 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 205918008346 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 205918008347 active site 205918008348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918008349 1 probable transmembrane helix predicted by TMHMM2.0 205918008350 calcium-activated chloride channel protein 1; Region: hCaCC; TIGR00868 205918008351 1 probable transmembrane helix predicted by TMHMM2.0 205918008352 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918008353 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 205918008354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205918008355 Walker A/P-loop; other site 205918008356 ATP binding site [chemical binding]; other site 205918008357 Q-loop/lid; other site 205918008358 ABC transporter signature motif; other site 205918008359 Walker B; other site 205918008360 D-loop; other site 205918008361 H-loop/switch region; other site 205918008362 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918008363 FtsX-like permease family; Region: FtsX; pfam02687 205918008364 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008365 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008366 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008367 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008368 macrolide transporter subunit MacA; Provisional; Region: PRK11578 205918008369 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918008370 E3 interaction surface; other site 205918008371 lipoyl attachment site [posttranslational modification]; other site 205918008372 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918008373 1 probable transmembrane helix predicted by TMHMM2.0 205918008374 Penicillin amidase; Region: Penicil_amidase; pfam01804 205918008375 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918008376 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 205918008377 active site 205918008378 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918008379 1 probable transmembrane helix predicted by TMHMM2.0 205918008380 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 205918008381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918008382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918008383 homodimer interface [polypeptide binding]; other site 205918008384 catalytic residue [active] 205918008385 excinuclease ABC subunit B; Provisional; Region: PRK05298 205918008386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918008387 ATP binding site [chemical binding]; other site 205918008388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918008389 nucleotide binding region [chemical binding]; other site 205918008390 ATP-binding site [chemical binding]; other site 205918008391 Ultra-violet resistance protein B; Region: UvrB; pfam12344 205918008392 UvrB/uvrC motif; Region: UVR; pfam02151 205918008393 putative transposase OrfB; Reviewed; Region: PHA02517 205918008394 HTH-like domain; Region: HTH_21; pfam13276 205918008395 Integrase core domain; Region: rve; pfam00665 205918008396 Integrase core domain; Region: rve_2; pfam13333 205918008397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918008398 Transposase; Region: HTH_Tnp_1; cl17663 205918008399 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 205918008400 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205918008401 HIGH motif; other site 205918008402 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205918008403 active site 205918008404 KMSKS motif; other site 205918008405 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918008406 active site 205918008407 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 205918008408 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205918008409 FMN binding site [chemical binding]; other site 205918008410 active site 205918008411 catalytic residues [active] 205918008412 substrate binding site [chemical binding]; other site 205918008413 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 205918008414 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 205918008415 putative dimer interface [polypeptide binding]; other site 205918008416 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 205918008417 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918008418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008419 putative active site [active] 205918008420 heme pocket [chemical binding]; other site 205918008421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918008422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918008423 metal binding site [ion binding]; metal-binding site 205918008424 active site 205918008425 I-site; other site 205918008426 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918008427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918008428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918008429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918008430 dimerization interface [polypeptide binding]; other site 205918008431 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 205918008432 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 205918008433 substrate binding site [chemical binding]; other site 205918008434 ligand binding site [chemical binding]; other site 205918008435 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 205918008436 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 205918008437 substrate binding site [chemical binding]; other site 205918008438 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 205918008439 tartrate dehydrogenase; Region: TTC; TIGR02089 205918008440 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 205918008441 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205918008442 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 205918008443 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 205918008444 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 205918008445 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 205918008446 active site 205918008447 intersubunit interface [polypeptide binding]; other site 205918008448 catalytic residue [active] 205918008449 galactonate dehydratase; Provisional; Region: PRK14017 205918008450 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 205918008451 putative active site pocket [active] 205918008452 putative metal binding site [ion binding]; other site 205918008453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008454 D-galactonate transporter; Region: 2A0114; TIGR00893 205918008455 putative substrate translocation pore; other site 205918008456 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008457 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008458 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008459 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008460 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008461 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008462 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008463 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008464 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008465 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008466 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918008467 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 205918008468 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918008469 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 205918008470 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 205918008471 putative NAD(P) binding site [chemical binding]; other site 205918008472 putative substrate binding site [chemical binding]; other site 205918008473 catalytic Zn binding site [ion binding]; other site 205918008474 structural Zn binding site [ion binding]; other site 205918008475 dimer interface [polypeptide binding]; other site 205918008476 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918008477 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 205918008478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918008479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918008480 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 205918008481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918008482 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 205918008483 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 205918008484 Ligand binding site [chemical binding]; other site 205918008485 Electron transfer flavoprotein domain; Region: ETF; pfam01012 205918008486 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 205918008487 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 205918008488 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 205918008489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008490 substrate binding pocket [chemical binding]; other site 205918008491 membrane-bound complex binding site; other site 205918008492 hinge residues; other site 205918008493 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 205918008494 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918008495 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918008496 ligand binding site [chemical binding]; other site 205918008497 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918008498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918008499 DNA-binding site [nucleotide binding]; DNA binding site 205918008500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918008501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918008502 homodimer interface [polypeptide binding]; other site 205918008503 catalytic residue [active] 205918008504 Flagellin N-methylase; Region: FliB; cl00497 205918008505 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 205918008506 putative lipid binding site [chemical binding]; other site 205918008507 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 205918008508 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 205918008509 dimer interface [polypeptide binding]; other site 205918008510 active site 205918008511 citrylCoA binding site [chemical binding]; other site 205918008512 NADH binding [chemical binding]; other site 205918008513 cationic pore residues; other site 205918008514 oxalacetate/citrate binding site [chemical binding]; other site 205918008515 coenzyme A binding site [chemical binding]; other site 205918008516 catalytic triad [active] 205918008517 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 205918008518 Iron-sulfur protein interface; other site 205918008519 proximal quinone binding site [chemical binding]; other site 205918008520 SdhD (CybS) interface [polypeptide binding]; other site 205918008521 proximal heme binding site [chemical binding]; other site 205918008522 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008523 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008524 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008525 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 205918008526 SdhC subunit interface [polypeptide binding]; other site 205918008527 proximal heme binding site [chemical binding]; other site 205918008528 cardiolipin binding site; other site 205918008529 Iron-sulfur protein interface; other site 205918008530 proximal quinone binding site [chemical binding]; other site 205918008531 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008532 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008533 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008534 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 205918008535 L-aspartate oxidase; Provisional; Region: PRK06175 205918008536 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205918008537 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 205918008538 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 205918008539 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 205918008540 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 205918008541 TPP-binding site [chemical binding]; other site 205918008542 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 205918008543 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 205918008544 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918008545 E3 interaction surface; other site 205918008546 lipoyl attachment site [posttranslational modification]; other site 205918008547 e3 binding domain; Region: E3_binding; pfam02817 205918008548 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 205918008549 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 205918008550 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 205918008551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918008552 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205918008553 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 205918008554 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 205918008555 CoA-ligase; Region: Ligase_CoA; pfam00549 205918008556 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 205918008557 CoA binding domain; Region: CoA_binding; pfam02629 205918008558 CoA-ligase; Region: Ligase_CoA; pfam00549 205918008559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918008560 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 205918008561 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008562 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008563 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008564 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008565 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008566 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008567 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008568 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008569 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008570 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008571 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008572 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008573 heat shock protein 90; Provisional; Region: PRK05218 205918008574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008575 ATP binding site [chemical binding]; other site 205918008576 Mg2+ binding site [ion binding]; other site 205918008577 G-X-G motif; other site 205918008578 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 205918008579 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918008580 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 205918008581 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918008582 dimer interface [polypeptide binding]; other site 205918008583 active site 205918008584 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 205918008585 active site 1 [active] 205918008586 dimer interface [polypeptide binding]; other site 205918008587 active site 2 [active] 205918008588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008589 dimerization interface [polypeptide binding]; other site 205918008590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918008591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008592 dimer interface [polypeptide binding]; other site 205918008593 phosphorylation site [posttranslational modification] 205918008594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008595 ATP binding site [chemical binding]; other site 205918008596 Mg2+ binding site [ion binding]; other site 205918008597 G-X-G motif; other site 205918008598 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918008599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008600 active site 205918008601 phosphorylation site [posttranslational modification] 205918008602 intermolecular recognition site; other site 205918008603 dimerization interface [polypeptide binding]; other site 205918008604 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008605 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008606 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 205918008607 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 205918008608 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 205918008609 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 205918008610 1 probable transmembrane helix predicted by TMHMM2.0 205918008611 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205918008612 catalytic core [active] 205918008613 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 205918008614 CoenzymeA binding site [chemical binding]; other site 205918008615 subunit interaction site [polypeptide binding]; other site 205918008616 PHB binding site; other site 205918008617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918008618 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918008619 1 probable transmembrane helix predicted by TMHMM2.0 205918008620 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 205918008621 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918008622 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008623 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008624 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008625 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008626 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008627 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008628 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008629 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 205918008630 Ca2+ binding site [ion binding]; other site 205918008631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918008632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008633 dimerization interface [polypeptide binding]; other site 205918008634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008635 dimer interface [polypeptide binding]; other site 205918008636 phosphorylation site [posttranslational modification] 205918008637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008638 ATP binding site [chemical binding]; other site 205918008639 Mg2+ binding site [ion binding]; other site 205918008640 G-X-G motif; other site 205918008641 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008642 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008643 osmolarity response regulator; Provisional; Region: ompR; PRK09468 205918008644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008645 active site 205918008646 phosphorylation site [posttranslational modification] 205918008647 intermolecular recognition site; other site 205918008648 dimerization interface [polypeptide binding]; other site 205918008649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918008650 DNA binding site [nucleotide binding] 205918008651 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 205918008652 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918008653 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918008654 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 205918008655 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 205918008656 PapC N-terminal domain; Region: PapC_N; pfam13954 205918008657 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 205918008658 PapC C-terminal domain; Region: PapC_C; pfam13953 205918008659 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 205918008660 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 205918008661 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 205918008662 1 probable transmembrane helix predicted by TMHMM2.0 205918008663 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 205918008664 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918008665 RHS Repeat; Region: RHS_repeat; pfam05593 205918008666 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918008667 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008668 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008669 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008670 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918008671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918008672 DNA binding residues [nucleotide binding] 205918008673 dimerization interface [polypeptide binding]; other site 205918008674 K+-transporting ATPase, KdpF subunit; Region: potass_kdpF; TIGR02115 205918008675 1 probable transmembrane helix predicted by TMHMM2.0 205918008676 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 205918008677 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008678 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008679 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008680 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008681 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008682 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008683 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008684 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008685 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008686 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008687 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 205918008688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918008689 Soluble P-type ATPase [General function prediction only]; Region: COG4087 205918008690 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008691 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008692 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008693 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008694 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008695 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008696 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008697 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 205918008698 1 probable transmembrane helix predicted by TMHMM2.0 205918008699 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 205918008700 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 205918008701 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 205918008702 Ligand Binding Site [chemical binding]; other site 205918008703 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 205918008704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008705 dimer interface [polypeptide binding]; other site 205918008706 phosphorylation site [posttranslational modification] 205918008707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008708 ATP binding site [chemical binding]; other site 205918008709 Mg2+ binding site [ion binding]; other site 205918008710 G-X-G motif; other site 205918008711 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008712 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008713 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008714 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 205918008715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008716 active site 205918008717 phosphorylation site [posttranslational modification] 205918008718 intermolecular recognition site; other site 205918008719 dimerization interface [polypeptide binding]; other site 205918008720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918008721 DNA binding site [nucleotide binding] 205918008722 MoxR-like ATPases [General function prediction only]; Region: COG0714 205918008723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918008724 Walker A motif; other site 205918008725 ATP binding site [chemical binding]; other site 205918008726 Walker B motif; other site 205918008727 arginine finger; other site 205918008728 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205918008729 Protein of unknown function DUF58; Region: DUF58; pfam01882 205918008730 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008731 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008732 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 205918008733 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205918008734 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 205918008735 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 205918008736 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008737 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008738 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008739 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008740 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008741 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008742 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 205918008743 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 205918008744 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 205918008745 active site 205918008746 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918008747 active site 2 [active] 205918008748 active site 1 [active] 205918008749 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 205918008750 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008751 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008753 dimerization interface [polypeptide binding]; other site 205918008754 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918008755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918008756 dimer interface [polypeptide binding]; other site 205918008757 putative CheW interface [polypeptide binding]; other site 205918008758 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008759 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008760 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205918008761 active site 205918008762 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205918008763 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008764 substrate binding pocket [chemical binding]; other site 205918008765 membrane-bound complex binding site; other site 205918008766 hinge residues; other site 205918008767 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 205918008768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918008769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918008770 catalytic residue [active] 205918008771 DoxX; Region: DoxX; pfam07681 205918008772 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008773 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008774 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008775 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205918008777 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 205918008778 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 205918008779 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918008780 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 205918008781 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008782 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008783 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008784 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008785 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008786 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008787 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008788 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008789 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008790 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008791 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 205918008792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205918008793 Walker A/P-loop; other site 205918008794 ATP binding site [chemical binding]; other site 205918008795 Q-loop/lid; other site 205918008796 ABC transporter signature motif; other site 205918008797 Walker B; other site 205918008798 D-loop; other site 205918008799 H-loop/switch region; other site 205918008800 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 205918008801 active site 205918008802 catalytic triad [active] 205918008803 oxyanion hole [active] 205918008804 switch loop; other site 205918008805 L,D-transpeptidase; Provisional; Region: PRK10260 205918008806 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205918008807 Predicted acetyltransferase [General function prediction only]; Region: COG2388 205918008808 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 205918008809 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205918008810 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 205918008811 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 205918008812 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 205918008813 1 probable transmembrane helix predicted by TMHMM2.0 205918008814 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 205918008815 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205918008816 Ligand Binding Site [chemical binding]; other site 205918008817 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 205918008818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918008819 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 205918008820 substrate binding site [chemical binding]; other site 205918008821 dimerization interface [polypeptide binding]; other site 205918008822 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 205918008823 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 205918008824 Active Sites [active] 205918008825 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 205918008826 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 205918008827 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 205918008828 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 205918008829 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 205918008830 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 205918008831 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 205918008832 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 205918008833 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 205918008834 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008835 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008836 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008837 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008838 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008839 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008840 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 205918008841 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918008842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918008843 DNA-binding site [nucleotide binding]; DNA binding site 205918008844 FCD domain; Region: FCD; pfam07729 205918008845 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 205918008846 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918008847 tetramer interface [polypeptide binding]; other site 205918008848 active site 205918008849 Mg2+/Mn2+ binding site [ion binding]; other site 205918008850 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 205918008851 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 205918008852 dimer interface [polypeptide binding]; other site 205918008853 active site 205918008854 citrylCoA binding site [chemical binding]; other site 205918008855 oxalacetate/citrate binding site [chemical binding]; other site 205918008856 coenzyme A binding site [chemical binding]; other site 205918008857 catalytic triad [active] 205918008858 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 205918008859 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 205918008860 substrate binding site [chemical binding]; other site 205918008861 ligand binding site [chemical binding]; other site 205918008862 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 205918008863 substrate binding site [chemical binding]; other site 205918008864 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 205918008865 PEP synthetase regulatory protein; Provisional; Region: PRK05339 205918008866 phosphoenolpyruvate synthase; Validated; Region: PRK06464 205918008867 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205918008868 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 205918008869 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 205918008870 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918008871 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205918008872 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 205918008873 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 205918008874 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 205918008875 Cl binding site [ion binding]; other site 205918008876 oligomer interface [polypeptide binding]; other site 205918008877 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008878 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008879 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008880 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008881 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008882 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008883 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008884 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 205918008885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918008886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918008887 DNA binding residues [nucleotide binding] 205918008888 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 205918008889 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918008890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918008891 ligand binding site [chemical binding]; other site 205918008892 1 probable transmembrane helix predicted by TMHMM2.0 205918008893 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 205918008894 active site 205918008895 SAM binding site [chemical binding]; other site 205918008896 homodimer interface [polypeptide binding]; other site 205918008897 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 205918008898 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 205918008899 [4Fe-4S] binding site [ion binding]; other site 205918008900 molybdopterin cofactor binding site; other site 205918008901 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 205918008902 molybdopterin cofactor binding site; other site 205918008903 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 205918008904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 205918008905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918008906 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 205918008907 active site 205918008908 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205918008909 active site 205918008910 ATP binding site [chemical binding]; other site 205918008911 substrate binding site [chemical binding]; other site 205918008912 activation loop (A-loop); other site 205918008913 1 probable transmembrane helix predicted by TMHMM2.0 205918008914 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 205918008915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008916 putative substrate translocation pore; other site 205918008917 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008918 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008919 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008920 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008921 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008922 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008923 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008924 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008925 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008926 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008927 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008928 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008929 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 205918008930 active site 205918008931 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 205918008932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008933 active site 205918008934 phosphorylation site [posttranslational modification] 205918008935 intermolecular recognition site; other site 205918008936 dimerization interface [polypeptide binding]; other site 205918008937 ANTAR domain; Region: ANTAR; pfam03861 205918008938 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 205918008939 NMT1-like family; Region: NMT1_2; pfam13379 205918008940 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 205918008941 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 205918008942 quinone interaction residues [chemical binding]; other site 205918008943 active site 205918008944 catalytic residues [active] 205918008945 FMN binding site [chemical binding]; other site 205918008946 substrate binding site [chemical binding]; other site 205918008947 Ribosome modulation factor; Region: RMF; pfam04957 205918008948 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 205918008949 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 205918008950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205918008951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918008952 S-adenosylmethionine binding site [chemical binding]; other site 205918008953 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918008954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008955 dimerization interface [polypeptide binding]; other site 205918008956 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918008957 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918008958 dimer interface [polypeptide binding]; other site 205918008959 putative CheW interface [polypeptide binding]; other site 205918008960 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008961 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008962 CHASE domain; Region: CHASE; pfam03924 205918008963 PAS domain S-box; Region: sensory_box; TIGR00229 205918008964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008965 putative active site [active] 205918008966 heme pocket [chemical binding]; other site 205918008967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008968 PAS fold; Region: PAS_3; pfam08447 205918008969 putative active site [active] 205918008970 heme pocket [chemical binding]; other site 205918008971 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918008972 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918008973 metal binding site [ion binding]; metal-binding site 205918008974 active site 205918008975 I-site; other site 205918008976 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008977 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008978 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 205918008979 hypothetical protein; Provisional; Region: PRK11702 205918008980 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 205918008981 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008982 substrate binding pocket [chemical binding]; other site 205918008983 membrane-bound complex binding site; other site 205918008984 hinge residues; other site 205918008985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008986 substrate binding pocket [chemical binding]; other site 205918008987 membrane-bound complex binding site; other site 205918008988 hinge residues; other site 205918008989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008990 putative active site [active] 205918008991 heme pocket [chemical binding]; other site 205918008992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008993 dimer interface [polypeptide binding]; other site 205918008994 phosphorylation site [posttranslational modification] 205918008995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008996 ATP binding site [chemical binding]; other site 205918008997 Mg2+ binding site [ion binding]; other site 205918008998 G-X-G motif; other site 205918008999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918009000 active site 205918009001 phosphorylation site [posttranslational modification] 205918009002 intermolecular recognition site; other site 205918009003 dimerization interface [polypeptide binding]; other site 205918009004 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918009005 putative binding surface; other site 205918009006 active site 205918009007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918009008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918009009 active site 205918009010 phosphorylation site [posttranslational modification] 205918009011 intermolecular recognition site; other site 205918009012 dimerization interface [polypeptide binding]; other site 205918009013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918009014 DNA binding residues [nucleotide binding] 205918009015 dimerization interface [polypeptide binding]; other site 205918009016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918009017 active site 205918009018 phosphorylation site [posttranslational modification] 205918009019 intermolecular recognition site; other site 205918009020 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 205918009021 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205918009022 Zn2+ binding site [ion binding]; other site 205918009023 Mg2+ binding site [ion binding]; other site 205918009024 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 205918009025 Predicted membrane protein [Function unknown]; Region: COG5393 205918009026 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009027 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009028 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 205918009029 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205918009030 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009031 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009032 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009033 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009034 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009035 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009036 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009037 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009038 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009039 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009040 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 205918009041 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 205918009042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918009043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918009044 dimerization interface [polypeptide binding]; other site 205918009045 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 205918009046 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 205918009047 active site 205918009048 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 205918009049 heterodimer interface [polypeptide binding]; other site 205918009050 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 205918009051 active site 205918009052 benzoate transport; Region: 2A0115; TIGR00895 205918009053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009054 putative substrate translocation pore; other site 205918009055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009056 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009057 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009058 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009059 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009060 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009061 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009062 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009063 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009064 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009065 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009066 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009067 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009068 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 205918009069 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 205918009070 tetramer interface [polypeptide binding]; other site 205918009071 active site 205918009072 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 205918009073 outer membrane porin, OprD family; Region: OprD; pfam03573 205918009074 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 205918009075 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009076 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009077 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009078 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009079 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009080 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009081 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009082 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009083 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009084 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009086 D-galactonate transporter; Region: 2A0114; TIGR00893 205918009087 putative substrate translocation pore; other site 205918009088 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009089 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009090 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009091 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009092 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009093 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009094 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009095 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009096 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009097 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 205918009098 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 205918009099 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 205918009100 dimer interface [polypeptide binding]; other site 205918009101 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 205918009102 active site 205918009103 Fe binding site [ion binding]; other site 205918009104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918009105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918009106 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 205918009107 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205918009108 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205918009109 shikimate binding site; other site 205918009110 NAD(P) binding site [chemical binding]; other site 205918009111 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205918009112 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205918009113 active site 205918009114 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 205918009115 1 probable transmembrane helix predicted by TMHMM2.0 205918009116 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 205918009117 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 205918009118 GTP binding site; other site 205918009119 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 205918009120 MPT binding site; other site 205918009121 trimer interface [polypeptide binding]; other site 205918009122 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 205918009123 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 205918009124 dimer interface [polypeptide binding]; other site 205918009125 putative functional site; other site 205918009126 putative MPT binding site; other site 205918009127 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918009128 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 205918009129 active site 205918009130 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 205918009131 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 205918009132 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 205918009133 TrkA-N domain; Region: TrkA_N; pfam02254 205918009134 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009135 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009136 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009137 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009138 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009139 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009140 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009141 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009142 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009143 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009144 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009145 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009146 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009147 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009148 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 205918009149 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918009150 FecR protein; Region: FecR; pfam04773 205918009151 1 probable transmembrane helix predicted by TMHMM2.0 205918009152 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 205918009153 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 205918009154 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205918009155 active site 205918009156 DNA-specific endonuclease I; Provisional; Region: PRK15137 205918009157 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 205918009158 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 205918009159 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 205918009160 1 probable transmembrane helix predicted by TMHMM2.0 205918009161 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 205918009162 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918009163 ligand binding site [chemical binding]; other site 205918009164 1 probable transmembrane helix predicted by TMHMM2.0 205918009165 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918009166 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918009167 Walker A/P-loop; other site 205918009168 ATP binding site [chemical binding]; other site 205918009169 Q-loop/lid; other site 205918009170 ABC transporter signature motif; other site 205918009171 Walker B; other site 205918009172 D-loop; other site 205918009173 H-loop/switch region; other site 205918009174 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918009175 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918009176 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918009177 TM-ABC transporter signature motif; other site 205918009178 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009179 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009180 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009181 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009182 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009183 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009184 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009185 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009186 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009187 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918009188 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918009189 DNA binding site [nucleotide binding] 205918009190 domain linker motif; other site 205918009191 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205918009192 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918009193 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 205918009194 substrate binding site [chemical binding]; other site 205918009195 dimer interface [polypeptide binding]; other site 205918009196 ATP binding site [chemical binding]; other site 205918009197 D-ribose pyranase; Provisional; Region: PRK11797 205918009198 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 205918009199 active site 205918009200 tetramer interface [polypeptide binding]; other site 205918009201 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 205918009202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205918009203 DNA-binding site [nucleotide binding]; DNA binding site 205918009204 RNA-binding motif; other site 205918009205 1 probable transmembrane helix predicted by TMHMM2.0 205918009206 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 205918009207 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 205918009208 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 205918009209 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 205918009210 active site 205918009211 dimer interface [polypeptide binding]; other site 205918009212 motif 1; other site 205918009213 motif 2; other site 205918009214 motif 3; other site 205918009215 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 205918009216 anticodon binding site; other site 205918009217 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 205918009218 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 205918009219 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 205918009220 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 205918009221 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 205918009222 23S rRNA binding site [nucleotide binding]; other site 205918009223 L21 binding site [polypeptide binding]; other site 205918009224 L13 binding site [polypeptide binding]; other site 205918009225 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 205918009226 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 205918009227 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 205918009228 dimer interface [polypeptide binding]; other site 205918009229 motif 1; other site 205918009230 active site 205918009231 motif 2; other site 205918009232 motif 3; other site 205918009233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 205918009234 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 205918009235 putative tRNA-binding site [nucleotide binding]; other site 205918009236 B3/4 domain; Region: B3_4; pfam03483 205918009237 tRNA synthetase B5 domain; Region: B5; smart00874 205918009238 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 205918009239 dimer interface [polypeptide binding]; other site 205918009240 motif 1; other site 205918009241 motif 3; other site 205918009242 motif 2; other site 205918009243 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 205918009244 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918009245 IHF dimer interface [polypeptide binding]; other site 205918009246 IHF - DNA interface [nucleotide binding]; other site 205918009247 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 205918009248 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 205918009249 DNA binding residues [nucleotide binding] 205918009250 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 205918009251 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918009252 substrate binding pocket [chemical binding]; other site 205918009253 membrane-bound complex binding site; other site 205918009254 hinge residues; other site 205918009255 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 205918009256 Uncharacterized conserved protein [Function unknown]; Region: COG3777 205918009257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918009258 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918009259 active site 2 [active] 205918009260 active site 1 [active] 205918009261 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 205918009262 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 205918009263 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 205918009264 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 205918009265 Ligand binding site [chemical binding]; other site 205918009266 Electron transfer flavoprotein domain; Region: ETF; pfam01012 205918009267 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 205918009268 CoA-transferase family III; Region: CoA_transf_3; pfam02515 205918009269 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918009270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918009271 active site 205918009272 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 205918009273 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 205918009274 TPP-binding site; other site 205918009275 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205918009276 PYR/PP interface [polypeptide binding]; other site 205918009277 dimer interface [polypeptide binding]; other site 205918009278 TPP binding site [chemical binding]; other site 205918009279 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 205918009280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009281 putative substrate translocation pore; other site 205918009282 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009283 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009284 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009285 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009286 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009287 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009288 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009289 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009290 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009291 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009292 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009293 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918009295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918009296 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 205918009297 putative dimerization interface [polypeptide binding]; other site 205918009298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009299 putative substrate translocation pore; other site 205918009300 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009301 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009302 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009303 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009304 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009305 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009306 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009307 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009308 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009309 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009310 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009311 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009312 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009313 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918009314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918009315 DNA-binding site [nucleotide binding]; DNA binding site 205918009316 FCD domain; Region: FCD; pfam07729 205918009317 short chain dehydrogenase; Provisional; Region: PRK12829 205918009318 classical (c) SDRs; Region: SDR_c; cd05233 205918009319 NAD(P) binding site [chemical binding]; other site 205918009320 active site 205918009321 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 205918009322 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918009323 benzoate transport; Region: 2A0115; TIGR00895 205918009324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009325 putative substrate translocation pore; other site 205918009326 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009327 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009328 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009329 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009330 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009331 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009332 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009333 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009334 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009335 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009336 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009337 CHASE3 domain; Region: CHASE3; pfam05227 205918009338 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 205918009339 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009341 dimer interface [polypeptide binding]; other site 205918009342 putative CheW interface [polypeptide binding]; other site 205918009343 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009344 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918009346 dimerization interface [polypeptide binding]; other site 205918009347 putative DNA binding site [nucleotide binding]; other site 205918009348 putative Zn2+ binding site [ion binding]; other site 205918009349 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918009350 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 205918009351 active site 205918009352 FMN binding site [chemical binding]; other site 205918009353 substrate binding site [chemical binding]; other site 205918009354 homotetramer interface [polypeptide binding]; other site 205918009355 catalytic residue [active] 205918009356 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 205918009357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918009358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918009359 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918009360 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918009361 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918009362 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918009363 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009364 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009365 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009366 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009367 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009368 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009369 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009370 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009371 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009372 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009373 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009374 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009375 UreD urease accessory protein; Region: UreD; pfam01774 205918009376 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918009377 urease subunit alpha; Reviewed; Region: ureC; PRK13308 205918009378 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 205918009379 subunit interactions [polypeptide binding]; other site 205918009380 active site 205918009381 flap region; other site 205918009382 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 205918009383 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 205918009384 alpha-gamma subunit interface [polypeptide binding]; other site 205918009385 beta-gamma subunit interface [polypeptide binding]; other site 205918009386 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 205918009387 alpha-beta subunit interface [polypeptide binding]; other site 205918009388 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 205918009389 UreF; Region: UreF; pfam01730 205918009390 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 205918009391 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 205918009392 dimer interface [polypeptide binding]; other site 205918009393 catalytic residues [active] 205918009394 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 205918009395 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 205918009396 Walker A/P-loop; other site 205918009397 ATP binding site [chemical binding]; other site 205918009398 Q-loop/lid; other site 205918009399 ABC transporter signature motif; other site 205918009400 Walker B; other site 205918009401 D-loop; other site 205918009402 H-loop/switch region; other site 205918009403 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 205918009404 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 205918009405 Walker A/P-loop; other site 205918009406 ATP binding site [chemical binding]; other site 205918009407 Q-loop/lid; other site 205918009408 ABC transporter signature motif; other site 205918009409 Walker B; other site 205918009410 D-loop; other site 205918009411 H-loop/switch region; other site 205918009412 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205918009413 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918009414 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 205918009415 TM-ABC transporter signature motif; other site 205918009416 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009417 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009418 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009419 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009420 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009421 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009422 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009423 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918009425 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918009426 TM-ABC transporter signature motif; other site 205918009427 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009428 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009429 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009430 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009431 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009432 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009433 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009434 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009435 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 205918009436 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 205918009437 putative ligand binding site [chemical binding]; other site 205918009438 1 probable transmembrane helix predicted by TMHMM2.0 205918009439 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 205918009440 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 205918009441 ligand binding site [chemical binding]; other site 205918009442 regulator interaction site; other site 205918009443 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 205918009444 ANTAR domain; Region: ANTAR; pfam03861 205918009445 amidase; Provisional; Region: PRK07235 205918009446 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918009447 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918009448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918009449 substrate binding pocket [chemical binding]; other site 205918009450 membrane-bound complex binding site; other site 205918009451 1 probable transmembrane helix predicted by TMHMM2.0 205918009452 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 205918009453 putative ligand binding site [chemical binding]; other site 205918009454 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205918009455 putative NAD binding site [chemical binding]; other site 205918009456 catalytic site [active] 205918009457 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918009458 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918009459 active site 205918009460 non-prolyl cis peptide bond; other site 205918009461 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 205918009462 active site 205918009463 Mn binding site [ion binding]; other site 205918009464 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 205918009465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918009466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009467 PAS domain; Region: PAS_9; pfam13426 205918009468 putative active site [active] 205918009469 heme pocket [chemical binding]; other site 205918009470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009471 PAS domain; Region: PAS_9; pfam13426 205918009472 putative active site [active] 205918009473 heme pocket [chemical binding]; other site 205918009474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009475 PAS domain; Region: PAS_9; pfam13426 205918009476 putative active site [active] 205918009477 heme pocket [chemical binding]; other site 205918009478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009479 PAS domain; Region: PAS_9; pfam13426 205918009480 putative active site [active] 205918009481 heme pocket [chemical binding]; other site 205918009482 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009483 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009484 dimer interface [polypeptide binding]; other site 205918009485 putative CheW interface [polypeptide binding]; other site 205918009486 CheW-like domain; Region: CheW; pfam01584 205918009487 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918009488 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918009489 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 205918009490 1 probable transmembrane helix predicted by TMHMM2.0 205918009491 transcriptional regulator; Provisional; Region: PRK10632 205918009492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918009493 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918009494 putative effector binding pocket; other site 205918009495 dimerization interface [polypeptide binding]; other site 205918009496 Cache domain; Region: Cache_1; pfam02743 205918009497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918009498 dimerization interface [polypeptide binding]; other site 205918009499 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009501 dimer interface [polypeptide binding]; other site 205918009502 putative CheW interface [polypeptide binding]; other site 205918009503 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009504 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009505 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 205918009506 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 205918009507 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 205918009508 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918009509 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 205918009510 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 205918009511 hydroxyglutarate oxidase; Provisional; Region: PRK11728 205918009512 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 205918009513 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205918009514 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205918009515 homodimer interface [polypeptide binding]; other site 205918009516 NADP binding site [chemical binding]; other site 205918009517 substrate binding site [chemical binding]; other site 205918009518 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 205918009519 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 205918009520 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 205918009521 putative active site [active] 205918009522 putative substrate binding site [chemical binding]; other site 205918009523 putative cosubstrate binding site; other site 205918009524 catalytic site [active] 205918009525 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 205918009526 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918009527 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918009528 N-terminal plug; other site 205918009529 ligand-binding site [chemical binding]; other site 205918009530 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 205918009531 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 205918009532 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009533 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009534 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009535 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009536 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009537 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009538 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009539 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009540 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009541 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009542 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009543 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918009544 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 205918009545 active site 205918009546 catalytic triad [active] 205918009547 dimer interface [polypeptide binding]; other site 205918009548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918009550 putative substrate translocation pore; other site 205918009551 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009552 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009553 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009554 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009555 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009556 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009557 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009558 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009559 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009560 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009561 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 205918009562 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918009563 Strictosidine synthase; Region: Str_synth; pfam03088 205918009564 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 205918009565 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 205918009566 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 205918009567 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009568 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009569 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009570 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009571 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009572 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918009574 dimerization interface [polypeptide binding]; other site 205918009575 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009577 dimer interface [polypeptide binding]; other site 205918009578 putative CheW interface [polypeptide binding]; other site 205918009579 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009580 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009581 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 205918009582 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918009583 putative ligand binding site [chemical binding]; other site 205918009584 1 probable transmembrane helix predicted by TMHMM2.0 205918009585 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 205918009586 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 205918009587 active site 205918009588 substrate binding site [chemical binding]; other site 205918009589 Mg2+ binding site [ion binding]; other site 205918009590 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918009591 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 205918009592 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009594 dimer interface [polypeptide binding]; other site 205918009595 putative CheW interface [polypeptide binding]; other site 205918009596 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009597 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009598 HAMP domain; Region: HAMP; pfam00672 205918009599 dimerization interface [polypeptide binding]; other site 205918009600 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009602 dimer interface [polypeptide binding]; other site 205918009603 putative CheW interface [polypeptide binding]; other site 205918009604 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009605 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009606 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 205918009607 homotrimer interaction site [polypeptide binding]; other site 205918009608 putative active site [active] 205918009609 DNA topoisomerase III; Provisional; Region: PRK07726 205918009610 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 205918009611 active site 205918009612 putative interdomain interaction site [polypeptide binding]; other site 205918009613 putative metal-binding site [ion binding]; other site 205918009614 putative nucleotide binding site [chemical binding]; other site 205918009615 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205918009616 domain I; other site 205918009617 DNA binding groove [nucleotide binding] 205918009618 phosphate binding site [ion binding]; other site 205918009619 domain II; other site 205918009620 domain III; other site 205918009621 nucleotide binding site [chemical binding]; other site 205918009622 catalytic site [active] 205918009623 domain IV; other site 205918009624 HDOD domain; Region: HDOD; pfam08668 205918009625 HD domain; Region: HD; pfam01966 205918009626 Cache domain; Region: Cache_1; pfam02743 205918009627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918009628 dimerization interface [polypeptide binding]; other site 205918009629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009631 dimer interface [polypeptide binding]; other site 205918009632 putative CheW interface [polypeptide binding]; other site 205918009633 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009634 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009635 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 205918009636 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 205918009637 Walker A/P-loop; other site 205918009638 ATP binding site [chemical binding]; other site 205918009639 Q-loop/lid; other site 205918009640 ABC transporter signature motif; other site 205918009641 Walker B; other site 205918009642 D-loop; other site 205918009643 H-loop/switch region; other site 205918009644 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 205918009645 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 205918009646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009647 dimer interface [polypeptide binding]; other site 205918009648 conserved gate region; other site 205918009649 ABC-ATPase subunit interface; other site 205918009650 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009651 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009652 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009653 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009654 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009655 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009656 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205918009657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918009658 DNA-binding site [nucleotide binding]; DNA binding site 205918009659 UTRA domain; Region: UTRA; pfam07702 205918009660 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 205918009661 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 205918009662 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 205918009663 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 205918009664 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 205918009665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918009666 Walker A/P-loop; other site 205918009667 ATP binding site [chemical binding]; other site 205918009668 Q-loop/lid; other site 205918009669 ABC transporter signature motif; other site 205918009670 Walker B; other site 205918009671 D-loop; other site 205918009672 H-loop/switch region; other site 205918009673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918009674 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 205918009675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918009676 Walker A/P-loop; other site 205918009677 ATP binding site [chemical binding]; other site 205918009678 Q-loop/lid; other site 205918009679 ABC transporter signature motif; other site 205918009680 Walker B; other site 205918009681 D-loop; other site 205918009682 H-loop/switch region; other site 205918009683 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 205918009684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918009685 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 205918009686 active site 205918009687 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Region: phosphon_PhnN; TIGR02322 205918009688 AAA domain; Region: AAA_18; pfam13238 205918009689 active site 205918009690 putative hydrolase; Provisional; Region: PRK02113 205918009691 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 205918009692 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918009693 Amidase; Region: Amidase; pfam01425 205918009694 glutamate carboxypeptidase; Reviewed; Region: PRK06133 205918009695 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 205918009696 metal binding site [ion binding]; metal-binding site 205918009697 dimer interface [polypeptide binding]; other site 205918009698 hypothetical protein; Provisional; Region: PRK07079 205918009699 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 205918009700 metal binding site [ion binding]; metal-binding site 205918009701 putative dimer interface [polypeptide binding]; other site 205918009702 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918009703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918009704 Walker A/P-loop; other site 205918009705 ATP binding site [chemical binding]; other site 205918009706 Q-loop/lid; other site 205918009707 ABC transporter signature motif; other site 205918009708 Walker B; other site 205918009709 D-loop; other site 205918009710 H-loop/switch region; other site 205918009711 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918009712 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918009713 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918009714 Walker A/P-loop; other site 205918009715 ATP binding site [chemical binding]; other site 205918009716 Q-loop/lid; other site 205918009717 ABC transporter signature motif; other site 205918009718 Walker B; other site 205918009719 D-loop; other site 205918009720 H-loop/switch region; other site 205918009721 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918009722 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918009723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009724 dimer interface [polypeptide binding]; other site 205918009725 conserved gate region; other site 205918009726 putative PBP binding loops; other site 205918009727 ABC-ATPase subunit interface; other site 205918009728 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009729 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009730 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009731 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009732 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009733 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918009735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009736 dimer interface [polypeptide binding]; other site 205918009737 conserved gate region; other site 205918009738 putative PBP binding loops; other site 205918009739 ABC-ATPase subunit interface; other site 205918009740 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009741 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009742 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009743 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009744 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009745 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009746 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 205918009747 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918009748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918009749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918009750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918009751 dimerization interface [polypeptide binding]; other site 205918009752 putative GTP cyclohydrolase; Provisional; Region: PRK13674 205918009753 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 205918009754 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 205918009755 trimer interface [polypeptide binding]; other site 205918009756 active site 205918009757 Predicted membrane protein [Function unknown]; Region: COG3503 205918009758 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009759 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009760 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009761 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009762 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009763 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009764 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009765 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009766 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009767 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 205918009768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918009769 non-specific DNA binding site [nucleotide binding]; other site 205918009770 salt bridge; other site 205918009771 sequence-specific DNA binding site [nucleotide binding]; other site 205918009772 Cupin domain; Region: Cupin_2; pfam07883 205918009773 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 205918009774 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205918009775 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918009776 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 205918009777 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 205918009778 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 205918009779 putative active site [active] 205918009780 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 205918009781 domain_subunit interface; other site 205918009782 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 205918009783 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 205918009784 active site 205918009785 FMN binding site [chemical binding]; other site 205918009786 substrate binding site [chemical binding]; other site 205918009787 3Fe-4S cluster binding site [ion binding]; other site 205918009788 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 205918009789 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009790 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009791 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009792 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009793 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009794 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009795 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009796 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009797 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009798 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009799 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009800 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009801 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 205918009802 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918009803 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 205918009804 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918009805 active site 205918009806 dimer interface [polypeptide binding]; other site 205918009807 non-prolyl cis peptide bond; other site 205918009808 insertion regions; other site 205918009809 Cache domain; Region: Cache_1; pfam02743 205918009810 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918009811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918009812 metal binding site [ion binding]; metal-binding site 205918009813 active site 205918009814 I-site; other site 205918009815 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009816 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009817 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 205918009818 Protein export membrane protein; Region: SecD_SecF; cl14618 205918009819 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009820 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009821 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009822 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009823 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009824 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009825 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009826 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009827 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009828 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009829 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009830 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009831 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 205918009832 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918009833 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918009834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 205918009835 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 205918009836 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 205918009837 Cu(I) binding site [ion binding]; other site 205918009838 Protein of unknown function (DUF461); Region: DUF461; pfam04314 205918009839 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918009840 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918009841 1 probable transmembrane helix predicted by TMHMM2.0 205918009842 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 205918009843 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009844 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009845 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009846 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918009847 TolR protein; Region: tolR; TIGR02801 205918009848 1 probable transmembrane helix predicted by TMHMM2.0 205918009849 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 205918009850 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918009851 N-terminal plug; other site 205918009852 ligand-binding site [chemical binding]; other site 205918009853 aldolase II superfamily protein; Provisional; Region: PRK07044 205918009854 active site 205918009855 intersubunit interface [polypeptide binding]; other site 205918009856 Zn2+ binding site [ion binding]; other site 205918009857 glutaminase; Provisional; Region: PRK00971 205918009858 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 205918009859 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 205918009860 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 205918009861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918009862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918009863 Walker A/P-loop; other site 205918009864 ATP binding site [chemical binding]; other site 205918009865 Q-loop/lid; other site 205918009866 ABC transporter signature motif; other site 205918009867 Walker B; other site 205918009868 D-loop; other site 205918009869 H-loop/switch region; other site 205918009870 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009871 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009872 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009873 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009874 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918009876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918009877 active site 205918009878 catalytic tetrad [active] 205918009879 glucose-1-dehydrogenase; Provisional; Region: PRK08936 205918009880 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 205918009881 NAD binding site [chemical binding]; other site 205918009882 homodimer interface [polypeptide binding]; other site 205918009883 active site 205918009884 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 205918009885 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 205918009886 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009887 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009888 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009889 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009890 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009891 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009892 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009893 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009894 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009895 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 205918009896 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009897 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009898 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009899 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009900 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009901 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009902 short chain dehydrogenase; Provisional; Region: PRK07102 205918009903 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 205918009904 NAD(P) binding site [chemical binding]; other site 205918009905 active site 205918009906 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 205918009907 FAD binding domain; Region: FAD_binding_4; pfam01565 205918009908 hypothetical protein; Validated; Region: PRK08238 205918009909 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 205918009910 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 205918009911 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009912 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009913 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009914 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009915 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009916 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009917 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009918 benzoate transport; Region: 2A0115; TIGR00895 205918009919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009920 putative substrate translocation pore; other site 205918009921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009922 putative substrate translocation pore; other site 205918009923 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009924 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009925 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009926 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009927 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009928 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009929 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009930 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009931 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009932 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009933 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009934 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009935 manganese transport protein MntH; Reviewed; Region: PRK00701 205918009936 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 205918009937 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009938 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009939 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009940 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009941 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009942 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009943 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009944 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009945 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009946 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009947 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009948 benzoate transport; Region: 2A0115; TIGR00895 205918009949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009950 putative substrate translocation pore; other site 205918009951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009952 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009953 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009954 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009955 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009956 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009957 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009958 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009959 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009960 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009961 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009962 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009963 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 205918009964 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 205918009965 NmrA-like family; Region: NmrA; pfam05368 205918009966 NADP binding site [chemical binding]; other site 205918009967 Predicted transcriptional regulators [Transcription]; Region: COG1733 205918009968 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 205918009969 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 205918009970 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205918009971 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 205918009972 1 probable transmembrane helix predicted by TMHMM2.0 205918009973 pyruvate dehydrogenase; Provisional; Region: PRK09124 205918009974 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 205918009975 PYR/PP interface [polypeptide binding]; other site 205918009976 tetramer interface [polypeptide binding]; other site 205918009977 dimer interface [polypeptide binding]; other site 205918009978 TPP binding site [chemical binding]; other site 205918009979 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 205918009980 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 205918009981 TPP-binding site [chemical binding]; other site 205918009982 Nitrate and nitrite sensing; Region: NIT; pfam08376 205918009983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009984 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009986 dimer interface [polypeptide binding]; other site 205918009987 putative CheW interface [polypeptide binding]; other site 205918009988 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009989 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009990 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 205918009991 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918009992 1 probable transmembrane helix predicted by TMHMM2.0 205918009993 general secretion pathway protein K 205918009994 general secretion pathway protein K 205918009995 methyl-accepting chemotaxis protein 205918009996 RHS Repeat; Region: RHS_repeat; cl11982 205918009997 RHS Repeat; Region: RHS_repeat; cl11982 205918009998 RHS Repeat; Region: RHS_repeat; cl11982 205918009999 RHS Repeat; Region: RHS_repeat; cl11982 205918010000 RHS Repeat; Region: RHS_repeat; pfam05593 205918010001 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918010002 RHS Repeat; Region: RHS_repeat; pfam05593 205918010003 RHS Repeat; Region: RHS_repeat; pfam05593 205918010004 RHS Repeat; Region: RHS_repeat; pfam05593 205918010005 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918010006 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 205918010007 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 205918010008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918010009 FeS/SAM binding site; other site 205918010010 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 205918010011 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 205918010012 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010013 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010014 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010015 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010016 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010017 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010018 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010019 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010020 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010021 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010022 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918010023 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205918010024 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918010025 1 probable transmembrane helix predicted by TMHMM2.0 205918010026 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918010027 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 205918010028 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 205918010029 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 205918010030 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205918010031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010032 dimer interface [polypeptide binding]; other site 205918010033 conserved gate region; other site 205918010034 putative PBP binding loops; other site 205918010035 ABC-ATPase subunit interface; other site 205918010036 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010037 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010038 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010039 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010040 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010041 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010042 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 205918010043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010044 dimer interface [polypeptide binding]; other site 205918010045 conserved gate region; other site 205918010046 putative PBP binding loops; other site 205918010047 ABC-ATPase subunit interface; other site 205918010048 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010049 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010050 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010051 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010052 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010053 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010054 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918010055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918010056 Walker A/P-loop; other site 205918010057 ATP binding site [chemical binding]; other site 205918010058 Q-loop/lid; other site 205918010059 ABC transporter signature motif; other site 205918010060 Walker B; other site 205918010061 D-loop; other site 205918010062 H-loop/switch region; other site 205918010063 TOBE domain; Region: TOBE_2; pfam08402 205918010064 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918010065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918010066 putative DNA binding site [nucleotide binding]; other site 205918010067 putative Zn2+ binding site [ion binding]; other site 205918010068 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918010069 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 205918010070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918010071 S-adenosylmethionine binding site [chemical binding]; other site 205918010072 Predicted membrane protein [Function unknown]; Region: COG3619 205918010073 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010074 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010075 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010076 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010077 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010078 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010079 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 205918010080 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918010081 1 probable transmembrane helix predicted by TMHMM2.0 205918010082 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 205918010083 FOG: CBS domain [General function prediction only]; Region: COG0517 205918010084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918010085 Transporter associated domain; Region: CorC_HlyC; smart01091 205918010086 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010087 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010088 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010089 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010090 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010091 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010092 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010093 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918010094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918010095 Coenzyme A binding pocket [chemical binding]; other site 205918010096 conserved hypothetical protein 205918010097 AAA domain; Region: AAA_21; pfam13304 205918010098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918010099 Walker A/P-loop; other site 205918010100 ATP binding site [chemical binding]; other site 205918010101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918010102 Walker B; other site 205918010103 D-loop; other site 205918010104 H-loop/switch region; other site 205918010105 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 205918010106 active site 205918010107 metal binding site [ion binding]; metal-binding site 205918010108 homotetramer interface [polypeptide binding]; other site 205918010109 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205918010110 active site 205918010111 dimer interface [polypeptide binding]; other site 205918010112 motif 2; other site 205918010113 putative acetyltransferase YhhY; Provisional; Region: PRK10140 205918010114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918010115 Coenzyme A binding pocket [chemical binding]; other site 205918010116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 205918010117 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 205918010118 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010119 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010120 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010121 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 205918010122 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918010123 GAF domain; Region: GAF; pfam01590 205918010124 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918010125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918010126 dimerization interface [polypeptide binding]; other site 205918010127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918010128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918010129 dimer interface [polypeptide binding]; other site 205918010130 putative CheW interface [polypeptide binding]; other site 205918010131 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010132 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918010134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 205918010136 putative effector binding pocket; other site 205918010137 putative dimerization interface [polypeptide binding]; other site 205918010138 acetylornithine aminotransferase; Provisional; Region: PRK02627 205918010139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918010140 inhibitor-cofactor binding pocket; inhibition site 205918010141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918010142 catalytic residue [active] 205918010143 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 205918010144 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 205918010145 FOG: CBS domain [General function prediction only]; Region: COG0517 205918010146 DNA polymerase II; Reviewed; Region: PRK05762 205918010147 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 205918010148 active site 205918010149 catalytic site [active] 205918010150 substrate binding site [chemical binding]; other site 205918010151 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 205918010152 active site 205918010153 metal-binding site 205918010154 NAD-dependent deacetylase; Provisional; Region: PRK05333 205918010155 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 205918010156 NAD+ binding site [chemical binding]; other site 205918010157 substrate binding site [chemical binding]; other site 205918010158 Zn binding site [ion binding]; other site 205918010159 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918010160 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 205918010161 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 205918010162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918010163 FeS/SAM binding site; other site 205918010164 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205918010165 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 205918010166 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 205918010167 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918010168 ABC-ATPase subunit interface; other site 205918010169 dimer interface [polypeptide binding]; other site 205918010170 putative PBP binding regions; other site 205918010171 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010172 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010173 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010174 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010175 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010176 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010177 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010178 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010179 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 205918010180 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 205918010181 metal binding site [ion binding]; metal-binding site 205918010182 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 205918010183 active site 205918010184 catalytic residues [active] 205918010185 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918010186 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 205918010187 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 205918010188 ligand binding site [chemical binding]; other site 205918010189 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 205918010190 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918010191 Walker A/P-loop; other site 205918010192 ATP binding site [chemical binding]; other site 205918010193 Q-loop/lid; other site 205918010194 ABC transporter signature motif; other site 205918010195 Walker B; other site 205918010196 D-loop; other site 205918010197 H-loop/switch region; other site 205918010198 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918010199 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918010200 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918010201 TM-ABC transporter signature motif; other site 205918010202 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010203 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010204 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010205 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010206 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010207 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010208 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010209 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010210 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010211 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918010213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010214 dimer interface [polypeptide binding]; other site 205918010215 phosphorylation site [posttranslational modification] 205918010216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010217 ATP binding site [chemical binding]; other site 205918010218 Mg2+ binding site [ion binding]; other site 205918010219 G-X-G motif; other site 205918010220 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010221 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918010223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010224 active site 205918010225 phosphorylation site [posttranslational modification] 205918010226 intermolecular recognition site; other site 205918010227 dimerization interface [polypeptide binding]; other site 205918010228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918010229 DNA binding site [nucleotide binding] 205918010230 MltA-interacting protein MipA; Region: MipA; cl01504 205918010231 hypothetical protein; Provisional; Region: PRK06184 205918010232 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 205918010233 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 205918010234 dimer interface [polypeptide binding]; other site 205918010235 tetracycline repressor protein TetR; Provisional; Region: PRK13756 205918010236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918010237 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 205918010238 amino acid transporter; Region: 2A0306; TIGR00909 205918010239 Spore germination protein; Region: Spore_permease; cl17796 205918010240 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010241 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010242 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010243 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010244 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010245 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010246 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010247 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010248 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010249 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010250 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010251 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010252 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 205918010253 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 205918010254 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 205918010255 Protein of unknown function DUF72; Region: DUF72; pfam01904 205918010256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 205918010257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 205918010258 active site 205918010259 phosphorylation site [posttranslational modification] 205918010260 intermolecular recognition site; other site 205918010261 dimerization interface [polypeptide binding]; other site 205918010262 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 205918010263 GAF domain; Region: GAF; pfam01590 205918010264 Phytochrome region; Region: PHY; pfam00360 205918010265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010266 dimer interface [polypeptide binding]; other site 205918010267 phosphorylation site [posttranslational modification] 205918010268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010269 ATP binding site [chemical binding]; other site 205918010270 Mg2+ binding site [ion binding]; other site 205918010271 G-X-G motif; other site 205918010272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205918010273 HWE histidine kinase; Region: HWE_HK; pfam07536 205918010274 malate:quinone oxidoreductase; Validated; Region: PRK05257 205918010275 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 205918010276 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 205918010277 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 205918010278 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 205918010279 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 205918010280 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 205918010281 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 205918010282 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 205918010283 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 205918010284 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 205918010285 XdhC Rossmann domain; Region: XdhC_C; pfam13478 205918010286 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 205918010287 Ligand binding site; other site 205918010288 metal-binding site 205918010289 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 205918010290 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 205918010291 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 205918010292 NAD(P) binding site [chemical binding]; other site 205918010293 catalytic residues [active] 205918010294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918010295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010296 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 205918010297 putative dimerization interface [polypeptide binding]; other site 205918010298 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 205918010299 tartrate dehydrogenase; Region: TTC; TIGR02089 205918010300 transcriptional activator TtdR; Provisional; Region: PRK09801 205918010301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010302 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 205918010303 putative effector binding pocket; other site 205918010304 putative dimerization interface [polypeptide binding]; other site 205918010305 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918010306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918010307 Walker A/P-loop; other site 205918010308 ATP binding site [chemical binding]; other site 205918010309 Q-loop/lid; other site 205918010310 ABC transporter signature motif; other site 205918010311 Walker B; other site 205918010312 D-loop; other site 205918010313 H-loop/switch region; other site 205918010314 TOBE domain; Region: TOBE_2; pfam08402 205918010315 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918010316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010317 dimer interface [polypeptide binding]; other site 205918010318 conserved gate region; other site 205918010319 putative PBP binding loops; other site 205918010320 ABC-ATPase subunit interface; other site 205918010321 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010322 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010323 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010324 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010325 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010326 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010327 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010329 dimer interface [polypeptide binding]; other site 205918010330 conserved gate region; other site 205918010331 putative PBP binding loops; other site 205918010332 ABC-ATPase subunit interface; other site 205918010333 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010334 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010335 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010336 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010337 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010338 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010339 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918010340 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205918010341 1 probable transmembrane helix predicted by TMHMM2.0 205918010342 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 205918010343 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 205918010344 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 205918010345 dimerization interface [polypeptide binding]; other site 205918010346 active site 205918010347 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 205918010348 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 205918010349 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 205918010350 nudix motif; other site 205918010351 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918010352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918010353 DNA-binding site [nucleotide binding]; DNA binding site 205918010354 FCD domain; Region: FCD; pfam07729 205918010355 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 205918010356 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918010357 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 205918010358 NAD(P) binding site [chemical binding]; other site 205918010359 catalytic residues [active] 205918010360 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918010361 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 205918010362 Amino acid synthesis; Region: AA_synth; pfam06684 205918010363 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 205918010364 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 205918010365 NAD binding site [chemical binding]; other site 205918010366 catalytic Zn binding site [ion binding]; other site 205918010367 structural Zn binding site [ion binding]; other site 205918010368 short chain dehydrogenase; Provisional; Region: PRK06701 205918010369 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 205918010370 NAD binding site [chemical binding]; other site 205918010371 metal binding site [ion binding]; metal-binding site 205918010372 active site 205918010373 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918010374 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918010375 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918010376 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 205918010377 tetramerization interface [polypeptide binding]; other site 205918010378 NAD(P) binding site [chemical binding]; other site 205918010379 catalytic residues [active] 205918010380 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 205918010381 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 205918010382 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010383 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010384 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 205918010385 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205918010386 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205918010387 shikimate binding site; other site 205918010388 NAD(P) binding site [chemical binding]; other site 205918010389 Protein of unknown function, DUF480; Region: DUF480; pfam04337 205918010390 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 205918010391 putative arabinose transporter; Provisional; Region: PRK03545 205918010392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010393 putative substrate translocation pore; other site 205918010394 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010395 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010396 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010397 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010398 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010399 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010400 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010401 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010402 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010403 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010404 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010405 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010406 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 205918010407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010408 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 205918010409 putative dimerization interface [polypeptide binding]; other site 205918010410 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 205918010411 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010412 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010413 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010414 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010415 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010416 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010417 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010418 1 probable transmembrane helix predicted by TMHMM2.0 205918010419 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 205918010420 putative active site [active] 205918010421 1 probable transmembrane helix predicted by TMHMM2.0 205918010422 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918010423 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918010424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918010425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918010426 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 205918010427 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918010428 NAD(P) binding site [chemical binding]; other site 205918010429 active site 205918010430 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 205918010431 nudix motif; other site 205918010432 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 205918010433 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 205918010434 putative NAD(P) binding site [chemical binding]; other site 205918010435 putative substrate binding site [chemical binding]; other site 205918010436 catalytic Zn binding site [ion binding]; other site 205918010437 structural Zn binding site [ion binding]; other site 205918010438 dimer interface [polypeptide binding]; other site 205918010439 GAF domain; Region: GAF; cl17456 205918010440 GAF domain; Region: GAF_3; pfam13492 205918010441 GAF domain; Region: GAF_2; pfam13185 205918010442 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918010443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918010444 metal binding site [ion binding]; metal-binding site 205918010445 active site 205918010446 I-site; other site 205918010447 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918010448 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918010449 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 205918010450 putative substrate binding site [chemical binding]; other site 205918010451 putative ATP binding site [chemical binding]; other site 205918010452 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 205918010453 N- and C-terminal domain interface [polypeptide binding]; other site 205918010454 D-xylulose kinase; Region: XylB; TIGR01312 205918010455 active site 205918010456 MgATP binding site [chemical binding]; other site 205918010457 catalytic site [active] 205918010458 metal binding site [ion binding]; metal-binding site 205918010459 xylulose binding site [chemical binding]; other site 205918010460 putative homodimer interface [polypeptide binding]; other site 205918010461 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 205918010462 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 205918010463 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 205918010464 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918010465 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 205918010466 Walker A/P-loop; other site 205918010467 ATP binding site [chemical binding]; other site 205918010468 Q-loop/lid; other site 205918010469 ABC transporter signature motif; other site 205918010470 Walker B; other site 205918010471 D-loop; other site 205918010472 H-loop/switch region; other site 205918010473 TOBE domain; Region: TOBE_2; pfam08402 205918010474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918010475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010476 dimer interface [polypeptide binding]; other site 205918010477 conserved gate region; other site 205918010478 ABC-ATPase subunit interface; other site 205918010479 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010480 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010481 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010482 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010483 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010484 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010486 dimer interface [polypeptide binding]; other site 205918010487 conserved gate region; other site 205918010488 putative PBP binding loops; other site 205918010489 ABC-ATPase subunit interface; other site 205918010490 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010491 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010492 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010493 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010494 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010495 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918010497 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205918010498 1 probable transmembrane helix predicted by TMHMM2.0 205918010499 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 205918010500 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 205918010501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918010502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918010503 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 205918010504 active site 205918010505 SAM binding site [chemical binding]; other site 205918010506 homodimer interface [polypeptide binding]; other site 205918010507 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 205918010508 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918010509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010510 active site 205918010511 phosphorylation site [posttranslational modification] 205918010512 intermolecular recognition site; other site 205918010513 dimerization interface [polypeptide binding]; other site 205918010514 CHASE3 domain; Region: CHASE3; pfam05227 205918010515 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918010516 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 205918010517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010518 dimer interface [polypeptide binding]; other site 205918010519 phosphorylation site [posttranslational modification] 205918010520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010521 ATP binding site [chemical binding]; other site 205918010522 Mg2+ binding site [ion binding]; other site 205918010523 G-X-G motif; other site 205918010524 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010526 active site 205918010527 phosphorylation site [posttranslational modification] 205918010528 intermolecular recognition site; other site 205918010529 dimerization interface [polypeptide binding]; other site 205918010530 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918010531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010532 active site 205918010533 phosphorylation site [posttranslational modification] 205918010534 intermolecular recognition site; other site 205918010535 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010537 active site 205918010538 phosphorylation site [posttranslational modification] 205918010539 intermolecular recognition site; other site 205918010540 dimerization interface [polypeptide binding]; other site 205918010541 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010542 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010543 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918010544 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 205918010545 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 205918010546 CheB methylesterase; Region: CheB_methylest; pfam01339 205918010547 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010549 active site 205918010550 phosphorylation site [posttranslational modification] 205918010551 intermolecular recognition site; other site 205918010552 dimerization interface [polypeptide binding]; other site 205918010553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205918010554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010555 dimer interface [polypeptide binding]; other site 205918010556 phosphorylation site [posttranslational modification] 205918010557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010558 ATP binding site [chemical binding]; other site 205918010559 Mg2+ binding site [ion binding]; other site 205918010560 G-X-G motif; other site 205918010561 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010563 active site 205918010564 phosphorylation site [posttranslational modification] 205918010565 intermolecular recognition site; other site 205918010566 dimerization interface [polypeptide binding]; other site 205918010567 PAS fold; Region: PAS_3; pfam08447 205918010568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918010569 heme pocket [chemical binding]; other site 205918010570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010571 dimer interface [polypeptide binding]; other site 205918010572 phosphorylation site [posttranslational modification] 205918010573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010574 ATP binding site [chemical binding]; other site 205918010575 Mg2+ binding site [ion binding]; other site 205918010576 G-X-G motif; other site 205918010577 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918010578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010579 active site 205918010580 phosphorylation site [posttranslational modification] 205918010581 intermolecular recognition site; other site 205918010582 dimerization interface [polypeptide binding]; other site 205918010583 circadian clock protein KaiC; Reviewed; Region: PRK09302 205918010584 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918010585 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918010586 Walker A motif; other site 205918010587 Walker A motif; other site 205918010588 ATP binding site [chemical binding]; other site 205918010589 Walker B motif; other site 205918010590 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918010591 Walker A motif; other site 205918010592 ATP binding site [chemical binding]; other site 205918010593 Walker B motif; other site 205918010594 enoyl-CoA hydratase; Provisional; Region: PRK06142 205918010595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918010596 substrate binding site [chemical binding]; other site 205918010597 oxyanion hole (OAH) forming residues; other site 205918010598 trimer interface [polypeptide binding]; other site 205918010599 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 205918010600 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 205918010601 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 205918010602 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 205918010603 putative NADH binding site [chemical binding]; other site 205918010604 putative active site [active] 205918010605 nudix motif; other site 205918010606 putative metal binding site [ion binding]; other site 205918010607 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205918010608 hypothetical protein; Provisional; Region: PRK10621 205918010609 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010610 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010611 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010612 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010613 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010614 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010615 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205918010616 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 205918010617 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 205918010618 short chain dehydrogenase; Provisional; Region: PRK07035 205918010619 classical (c) SDRs; Region: SDR_c; cd05233 205918010620 NAD(P) binding site [chemical binding]; other site 205918010621 active site 205918010622 Phosphotransferase enzyme family; Region: APH; pfam01636 205918010623 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 205918010624 putative active site [active] 205918010625 putative substrate binding site [chemical binding]; other site 205918010626 ATP binding site [chemical binding]; other site 205918010627 SCP-2 sterol transfer family; Region: SCP2; pfam02036 205918010628 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205918010629 catalytic core [active] 205918010630 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 205918010631 putative inner membrane peptidase; Provisional; Region: PRK11778 205918010632 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 205918010633 tandem repeat interface [polypeptide binding]; other site 205918010634 oligomer interface [polypeptide binding]; other site 205918010635 active site residues [active] 205918010636 1 probable transmembrane helix predicted by TMHMM2.0 205918010637 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 205918010638 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 205918010639 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918010640 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918010641 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 205918010642 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918010643 putative ligand binding site [chemical binding]; other site 205918010644 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 205918010645 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 205918010646 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 205918010647 substrate binding pocket [chemical binding]; other site 205918010648 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 205918010649 B12 binding site [chemical binding]; other site 205918010650 cobalt ligand [ion binding]; other site 205918010651 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 205918010652 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205918010653 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010654 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010655 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010656 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010657 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010658 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010659 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010660 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010661 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010662 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 205918010663 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 205918010664 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 205918010665 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 205918010666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918010667 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 205918010668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 205918010669 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918010670 carboxyltransferase (CT) interaction site; other site 205918010671 biotinylation site [posttranslational modification]; other site 205918010672 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 205918010673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918010674 substrate binding site [chemical binding]; other site 205918010675 oxyanion hole (OAH) forming residues; other site 205918010676 trimer interface [polypeptide binding]; other site 205918010677 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 205918010678 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 205918010679 isovaleryl-CoA dehydrogenase; Region: PLN02519 205918010680 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 205918010681 substrate binding site [chemical binding]; other site 205918010682 FAD binding site [chemical binding]; other site 205918010683 catalytic base [active] 205918010684 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 205918010685 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 205918010686 active site 205918010687 catalytic residues [active] 205918010688 metal binding site [ion binding]; metal-binding site 205918010689 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 205918010690 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205918010691 DNA binding residues [nucleotide binding] 205918010692 putative dimer interface [polypeptide binding]; other site 205918010693 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 205918010694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010695 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 205918010696 substrate binding pocket [chemical binding]; other site 205918010697 dimerization interface [polypeptide binding]; other site 205918010698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918010699 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 205918010700 FAD binding site [chemical binding]; other site 205918010701 substrate binding site [chemical binding]; other site 205918010702 catalytic base [active] 205918010703 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 205918010704 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918010705 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918010706 ligand binding site [chemical binding]; other site 205918010707 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 205918010708 putative catalytic site [active] 205918010709 putative phosphate binding site [ion binding]; other site 205918010710 active site 205918010711 metal binding site A [ion binding]; metal-binding site 205918010712 DNA binding site [nucleotide binding] 205918010713 putative AP binding site [nucleotide binding]; other site 205918010714 putative metal binding site B [ion binding]; other site 205918010715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 205918010716 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918010717 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 205918010718 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918010719 Surface antigen; Region: Bac_surface_Ag; pfam01103 205918010720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 205918010721 Family of unknown function (DUF490); Region: DUF490; pfam04357 205918010722 1 probable transmembrane helix predicted by TMHMM2.0 205918010723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918010724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010725 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 205918010726 putative effector binding pocket; other site 205918010727 putative dimerization interface [polypeptide binding]; other site 205918010728 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 205918010729 dimer interface [polypeptide binding]; other site 205918010730 catalytic triad [active] 205918010731 peroxidatic and resolving cysteines [active] 205918010732 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 205918010733 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918010734 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918010735 1 probable transmembrane helix predicted by TMHMM2.0 205918010736 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 205918010737 Protein export membrane protein; Region: SecD_SecF; cl14618 205918010738 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010739 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010740 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010741 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010742 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010743 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010744 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010748 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010749 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010750 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 205918010751 Protein export membrane protein; Region: SecD_SecF; cl14618 205918010752 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010753 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010754 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010755 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010756 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010757 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010758 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010759 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010760 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010761 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010762 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918010763 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 205918010764 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 205918010765 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 205918010766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918010767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918010768 metal binding site [ion binding]; metal-binding site 205918010769 active site 205918010770 I-site; other site 205918010771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918010772 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010773 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010774 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010775 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010776 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010777 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010778 short chain dehydrogenase; Provisional; Region: PRK06123 205918010779 classical (c) SDRs; Region: SDR_c; cd05233 205918010780 NAD(P) binding site [chemical binding]; other site 205918010781 active site 205918010782 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 205918010783 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 205918010784 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 205918010785 active site 205918010786 homodimer interface [polypeptide binding]; other site 205918010787 catalytic site [active] 205918010788 acceptor binding site [chemical binding]; other site 205918010789 trehalose synthase; Region: treS_nterm; TIGR02456 205918010790 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 205918010791 active site 205918010792 catalytic site [active] 205918010793 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 205918010794 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 205918010795 glycogen branching enzyme; Provisional; Region: PRK05402 205918010796 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 205918010797 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 205918010798 active site 205918010799 catalytic site [active] 205918010800 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 205918010801 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 205918010802 Autotransporter beta-domain; Region: Autotransporter; smart00869 205918010803 major facilitator superfamily transporter; Provisional; Region: PRK05122 205918010804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010805 putative substrate translocation pore; other site 205918010806 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010807 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010808 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010809 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010810 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010811 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010812 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010813 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010814 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010815 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010816 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010817 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010818 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 205918010819 1 probable transmembrane helix predicted by TMHMM2.0 205918010820 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 205918010821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918010822 Walker A/P-loop; other site 205918010823 ATP binding site [chemical binding]; other site 205918010824 Q-loop/lid; other site 205918010825 ABC transporter signature motif; other site 205918010826 Walker B; other site 205918010827 D-loop; other site 205918010828 H-loop/switch region; other site 205918010829 ABC transporter; Region: ABC_tran_2; pfam12848 205918010830 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918010831 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 205918010832 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 205918010833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918010834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918010835 Coenzyme A binding pocket [chemical binding]; other site 205918010836 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918010837 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 205918010838 putative C-terminal domain interface [polypeptide binding]; other site 205918010839 putative GSH binding site (G-site) [chemical binding]; other site 205918010840 putative dimer interface [polypeptide binding]; other site 205918010841 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 205918010842 putative N-terminal domain interface [polypeptide binding]; other site 205918010843 putative dimer interface [polypeptide binding]; other site 205918010844 putative substrate binding pocket (H-site) [chemical binding]; other site 205918010845 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 205918010846 Hemerythrin family; Region: Hemerythrin-like; cl15774 205918010847 Fe binding site [ion binding]; other site 205918010848 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918010849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918010850 substrate binding pocket [chemical binding]; other site 205918010851 membrane-bound complex binding site; other site 205918010852 hinge residues; other site 205918010853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010854 dimer interface [polypeptide binding]; other site 205918010855 conserved gate region; other site 205918010856 putative PBP binding loops; other site 205918010857 ABC-ATPase subunit interface; other site 205918010858 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010859 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010860 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010861 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010862 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010863 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918010864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010865 dimer interface [polypeptide binding]; other site 205918010866 conserved gate region; other site 205918010867 putative PBP binding loops; other site 205918010868 ABC-ATPase subunit interface; other site 205918010869 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010870 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010871 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010872 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918010873 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918010874 Walker A/P-loop; other site 205918010875 ATP binding site [chemical binding]; other site 205918010876 Q-loop/lid; other site 205918010877 ABC transporter signature motif; other site 205918010878 Walker B; other site 205918010879 D-loop; other site 205918010880 H-loop/switch region; other site 205918010881 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918010882 homotrimer interaction site [polypeptide binding]; other site 205918010883 putative active site [active] 205918010884 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918010885 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 205918010886 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918010887 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 205918010888 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 205918010889 dimer interface [polypeptide binding]; other site 205918010890 active site 205918010891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918010892 substrate binding site [chemical binding]; other site 205918010893 catalytic residue [active] 205918010894 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 205918010895 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918010896 substrate binding site [chemical binding]; other site 205918010897 ATP binding site [chemical binding]; other site 205918010898 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205918010899 Family description; Region: UvrD_C_2; pfam13538 205918010900 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 205918010901 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918010902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205918010903 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918010904 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 205918010905 Walker A/P-loop; other site 205918010906 ATP binding site [chemical binding]; other site 205918010907 Q-loop/lid; other site 205918010908 ABC transporter signature motif; other site 205918010909 Walker B; other site 205918010910 D-loop; other site 205918010911 H-loop/switch region; other site 205918010912 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205918010913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010914 dimer interface [polypeptide binding]; other site 205918010915 conserved gate region; other site 205918010916 putative PBP binding loops; other site 205918010917 ABC-ATPase subunit interface; other site 205918010918 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010919 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010920 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010921 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010922 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010923 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010924 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918010925 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918010926 membrane-bound complex binding site; other site 205918010927 1 probable transmembrane helix predicted by TMHMM2.0 205918010928 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918010929 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918010930 active site 205918010931 catalytic tetrad [active] 205918010932 LexA repressor; Provisional; Region: PRK12423 205918010933 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 205918010934 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918010935 Catalytic site [active] 205918010936 Uncharacterized conserved protein [Function unknown]; Region: COG4544 205918010937 DNA Polymerase Y-family; Region: PolY_like; cd03468 205918010938 active site 205918010939 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 205918010940 DNA binding site [nucleotide binding] 205918010941 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 205918010942 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 205918010943 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 205918010944 putative active site [active] 205918010945 putative PHP Thumb interface [polypeptide binding]; other site 205918010946 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 205918010947 generic binding surface I; other site 205918010948 generic binding surface II; other site 205918010949 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 205918010950 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 205918010951 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 205918010952 oligomer interface [polypeptide binding]; other site 205918010953 Cl binding site [ion binding]; other site 205918010954 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010955 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010956 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 205918010957 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 205918010958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205918010959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918010960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918010961 Coenzyme A binding pocket [chemical binding]; other site 205918010962 Peptidase_C39 like family; Region: DUF3335; pfam11814 205918010963 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 205918010964 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 205918010965 NodB motif; other site 205918010966 active site 205918010967 catalytic site [active] 205918010968 metal binding site [ion binding]; metal-binding site 205918010969 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 205918010970 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918010971 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 205918010972 active site 205918010973 citrate-proton symporter; Provisional; Region: PRK15075 205918010974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010975 putative substrate translocation pore; other site 205918010976 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010977 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010978 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010979 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010980 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010981 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010982 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010983 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010984 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010985 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010986 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010987 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010988 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918010989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010991 dimerization interface [polypeptide binding]; other site 205918010992 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918010993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918010994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010995 dimerization interface [polypeptide binding]; other site 205918010996 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 205918010997 FAD binding domain; Region: FAD_binding_4; pfam01565 205918010998 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 205918010999 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 205918011000 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918011001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918011002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918011003 metal binding site [ion binding]; metal-binding site 205918011004 active site 205918011005 I-site; other site 205918011006 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011007 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011008 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011009 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011010 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011011 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918011013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918011014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918011015 dimerization interface [polypeptide binding]; other site 205918011016 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 205918011017 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 205918011018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918011019 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918011020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011021 dimer interface [polypeptide binding]; other site 205918011022 conserved gate region; other site 205918011023 putative PBP binding loops; other site 205918011024 ABC-ATPase subunit interface; other site 205918011025 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011026 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011027 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011028 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011029 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011030 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011031 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918011032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011033 dimer interface [polypeptide binding]; other site 205918011034 conserved gate region; other site 205918011035 putative PBP binding loops; other site 205918011036 ABC-ATPase subunit interface; other site 205918011037 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011038 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011039 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011040 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011041 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011042 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918011043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918011044 Walker A/P-loop; other site 205918011045 ATP binding site [chemical binding]; other site 205918011046 Q-loop/lid; other site 205918011047 ABC transporter signature motif; other site 205918011048 Walker B; other site 205918011049 D-loop; other site 205918011050 H-loop/switch region; other site 205918011051 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 205918011052 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 205918011053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918011054 Walker A/P-loop; other site 205918011055 ATP binding site [chemical binding]; other site 205918011056 Q-loop/lid; other site 205918011057 ABC transporter signature motif; other site 205918011058 Walker B; other site 205918011059 D-loop; other site 205918011060 H-loop/switch region; other site 205918011061 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 205918011062 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 205918011063 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918011064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 205918011065 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 205918011066 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 205918011067 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 205918011068 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918011069 active site 205918011070 metal binding site [ion binding]; metal-binding site 205918011071 hexamer interface [polypeptide binding]; other site 205918011072 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 205918011073 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011074 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011075 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011076 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011077 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 205918011078 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 205918011079 dimer interface [polypeptide binding]; other site 205918011080 active site 205918011081 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918011082 catalytic residues [active] 205918011083 substrate binding site [chemical binding]; other site 205918011084 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 205918011085 metal binding triad [ion binding]; metal-binding site 205918011086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918011087 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 205918011088 inhibitor-cofactor binding pocket; inhibition site 205918011089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011090 catalytic residue [active] 205918011091 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 205918011092 hydrophobic ligand binding site; other site 205918011093 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918011094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011095 NAD(P) binding site [chemical binding]; other site 205918011096 active site 205918011097 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918011098 Fatty acid desaturase; Region: FA_desaturase; pfam00487 205918011099 putative di-iron ligands [ion binding]; other site 205918011100 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918011101 1 probable transmembrane helix predicted by TMHMM2.0 205918011102 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 205918011103 trimer interface [polypeptide binding]; other site 205918011104 active site 205918011105 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205918011106 trimer interface [polypeptide binding]; other site 205918011107 active site 205918011108 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205918011109 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 205918011110 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205918011111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918011112 Walker A/P-loop; other site 205918011113 ATP binding site [chemical binding]; other site 205918011114 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 205918011115 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 205918011116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918011117 active site 205918011118 motif I; other site 205918011119 motif II; other site 205918011120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918011121 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918011122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918011123 DNA-binding site [nucleotide binding]; DNA binding site 205918011124 DAK2 domain; Region: Dak2; pfam02734 205918011125 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 205918011126 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 205918011127 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205918011128 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 205918011129 putative NAD(P) binding site [chemical binding]; other site 205918011130 catalytic Zn binding site [ion binding]; other site 205918011131 structural Zn binding site [ion binding]; other site 205918011132 short chain dehydrogenase; Provisional; Region: PRK06841 205918011133 classical (c) SDRs; Region: SDR_c; cd05233 205918011134 NAD(P) binding site [chemical binding]; other site 205918011135 active site 205918011136 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 205918011137 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918011138 putative ligand binding site [chemical binding]; other site 205918011139 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918011140 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918011141 TM-ABC transporter signature motif; other site 205918011142 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011143 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011144 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011145 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011146 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011147 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011148 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011149 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011150 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918011151 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918011152 Walker A/P-loop; other site 205918011153 ATP binding site [chemical binding]; other site 205918011154 Q-loop/lid; other site 205918011155 ABC transporter signature motif; other site 205918011156 Walker B; other site 205918011157 D-loop; other site 205918011158 H-loop/switch region; other site 205918011159 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918011160 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 205918011161 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 205918011162 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918011163 DNA binding residues [nucleotide binding] 205918011164 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 205918011165 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 205918011166 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 205918011167 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 205918011168 Trp docking motif [polypeptide binding]; other site 205918011169 putative active site [active] 205918011170 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011171 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011172 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011173 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011174 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918011176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918011177 DNA binding residues [nucleotide binding] 205918011178 dimerization interface [polypeptide binding]; other site 205918011179 Condensation domain; Region: Condensation; pfam00668 205918011180 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011181 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011182 acyl-activating enzyme (AAE) consensus motif; other site 205918011183 AMP binding site [chemical binding]; other site 205918011184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011185 Condensation domain; Region: Condensation; pfam00668 205918011186 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011187 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011188 acyl-activating enzyme (AAE) consensus motif; other site 205918011189 AMP binding site [chemical binding]; other site 205918011190 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011191 Condensation domain; Region: Condensation; pfam00668 205918011192 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011193 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011194 acyl-activating enzyme (AAE) consensus motif; other site 205918011195 AMP binding site [chemical binding]; other site 205918011196 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011197 Condensation domain; Region: Condensation; pfam00668 205918011198 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011199 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011200 acyl-activating enzyme (AAE) consensus motif; other site 205918011201 AMP binding site [chemical binding]; other site 205918011202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011203 Condensation domain; Region: Condensation; pfam00668 205918011204 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011205 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011206 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011207 acyl-activating enzyme (AAE) consensus motif; other site 205918011208 AMP binding site [chemical binding]; other site 205918011209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011210 Condensation domain; Region: Condensation; pfam00668 205918011211 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918011212 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011213 acyl-activating enzyme (AAE) consensus motif; other site 205918011214 AMP binding site [chemical binding]; other site 205918011215 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011216 Condensation domain; Region: Condensation; pfam00668 205918011217 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011218 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011219 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011220 acyl-activating enzyme (AAE) consensus motif; other site 205918011221 AMP binding site [chemical binding]; other site 205918011222 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011223 Condensation domain; Region: Condensation; pfam00668 205918011224 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011225 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011226 acyl-activating enzyme (AAE) consensus motif; other site 205918011227 AMP binding site [chemical binding]; other site 205918011228 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011229 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011230 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011231 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 205918011232 DNA binding residues [nucleotide binding] 205918011233 dimerization interface [polypeptide binding]; other site 205918011234 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 205918011235 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 205918011236 NAD(P) binding site [chemical binding]; other site 205918011237 catalytic residues [active] 205918011238 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 205918011239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918011240 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 205918011241 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918011242 FecR protein; Region: FecR; pfam04773 205918011243 Secretin and TonB N terminus short domain; Region: STN; smart00965 205918011244 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918011245 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918011246 N-terminal plug; other site 205918011247 ligand-binding site [chemical binding]; other site 205918011248 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 205918011249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918011250 inhibitor-cofactor binding pocket; inhibition site 205918011251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011252 catalytic residue [active] 205918011253 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 205918011254 IucA / IucC family; Region: IucA_IucC; pfam04183 205918011255 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918011256 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 205918011257 dimer interface [polypeptide binding]; other site 205918011258 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 205918011259 active site 205918011260 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918011261 catalytic residues [active] 205918011262 substrate binding site [chemical binding]; other site 205918011263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918011264 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918011265 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011266 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011267 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011268 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011269 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011270 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011271 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011272 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011273 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011274 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011275 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011276 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011277 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011278 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918011279 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 205918011280 IucA / IucC family; Region: IucA_IucC; pfam04183 205918011281 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918011282 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 205918011283 IucA / IucC family; Region: IucA_IucC; pfam04183 205918011284 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918011285 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 205918011286 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 205918011287 siderophore binding site; other site 205918011288 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 205918011289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918011290 ABC-ATPase subunit interface; other site 205918011291 dimer interface [polypeptide binding]; other site 205918011292 putative PBP binding regions; other site 205918011293 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011294 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011295 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011296 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011297 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011298 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011299 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011300 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011301 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011302 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 205918011303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918011304 ABC-ATPase subunit interface; other site 205918011305 dimer interface [polypeptide binding]; other site 205918011306 putative PBP binding regions; other site 205918011307 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011308 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011309 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011310 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011311 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011312 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011313 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011314 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918011315 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205918011316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918011317 Walker A/P-loop; other site 205918011318 ATP binding site [chemical binding]; other site 205918011319 Q-loop/lid; other site 205918011320 ABC transporter signature motif; other site 205918011321 Walker B; other site 205918011322 D-loop; other site 205918011323 H-loop/switch region; other site 205918011324 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 205918011325 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918011326 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 205918011327 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 205918011328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918011329 PAS domain; Region: PAS_9; pfam13426 205918011330 putative active site [active] 205918011331 heme pocket [chemical binding]; other site 205918011332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918011333 PAS domain; Region: PAS_9; pfam13426 205918011334 putative active site [active] 205918011335 heme pocket [chemical binding]; other site 205918011336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918011337 dimer interface [polypeptide binding]; other site 205918011338 putative CheW interface [polypeptide binding]; other site 205918011339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918011340 metal binding site [ion binding]; metal-binding site 205918011341 active site 205918011342 I-site; other site 205918011343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918011344 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011345 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011346 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 205918011347 Part of AAA domain; Region: AAA_19; pfam13245 205918011348 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 205918011349 AAA domain; Region: AAA_12; pfam13087 205918011350 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 205918011351 putative active site [active] 205918011352 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 205918011353 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 205918011354 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918011355 putative active site [active] 205918011356 putative metal binding site [ion binding]; other site 205918011357 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011358 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011359 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011360 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918011361 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 205918011362 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 205918011363 dimerization interface [polypeptide binding]; other site 205918011364 DNA binding residues [nucleotide binding] 205918011365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918011366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918011367 DNA binding residues [nucleotide binding] 205918011368 dimerization interface [polypeptide binding]; other site 205918011369 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918011370 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918011371 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918011372 1 probable transmembrane helix predicted by TMHMM2.0 205918011373 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918011374 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011375 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011376 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011377 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011378 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011379 Helix-turn-helix domain; Region: HTH_28; pfam13518 205918011380 Winged helix-turn helix; Region: HTH_29; pfam13551 205918011381 Homeodomain-like domain; Region: HTH_32; pfam13565 205918011382 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918011383 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 205918011384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918011385 DNA binding residues [nucleotide binding] 205918011386 dimerization interface [polypeptide binding]; other site 205918011387 Condensation domain; Region: Condensation; pfam00668 205918011388 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011389 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011390 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011391 acyl-activating enzyme (AAE) consensus motif; other site 205918011392 AMP binding site [chemical binding]; other site 205918011393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011394 Condensation domain; Region: Condensation; pfam00668 205918011395 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011396 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011397 acyl-activating enzyme (AAE) consensus motif; other site 205918011398 AMP binding site [chemical binding]; other site 205918011399 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011400 Condensation domain; Region: Condensation; pfam00668 205918011401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 205918011402 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011403 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011404 acyl-activating enzyme (AAE) consensus motif; other site 205918011405 AMP binding site [chemical binding]; other site 205918011406 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011407 Condensation domain; Region: Condensation; pfam00668 205918011408 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011409 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011410 acyl-activating enzyme (AAE) consensus motif; other site 205918011411 AMP binding site [chemical binding]; other site 205918011412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011413 Condensation domain; Region: Condensation; pfam00668 205918011414 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011415 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011416 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011417 acyl-activating enzyme (AAE) consensus motif; other site 205918011418 AMP binding site [chemical binding]; other site 205918011419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011420 Condensation domain; Region: Condensation; pfam00668 205918011421 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011422 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011423 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918011424 acyl-activating enzyme (AAE) consensus motif; other site 205918011425 AMP binding site [chemical binding]; other site 205918011426 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011427 Condensation domain; Region: Condensation; pfam00668 205918011428 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011429 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011430 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011431 acyl-activating enzyme (AAE) consensus motif; other site 205918011432 AMP binding site [chemical binding]; other site 205918011433 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011434 Condensation domain; Region: Condensation; pfam00668 205918011435 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011436 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011437 acyl-activating enzyme (AAE) consensus motif; other site 205918011438 AMP binding site [chemical binding]; other site 205918011439 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011440 Condensation domain; Region: Condensation; pfam00668 205918011441 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011442 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011443 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011444 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918011446 chlorinating enzyme; Region: chlorin-enz; TIGR01762 205918011447 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011448 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011449 acyl-activating enzyme (AAE) consensus motif; other site 205918011450 AMP binding site [chemical binding]; other site 205918011451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011452 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918011453 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 205918011454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918011455 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 205918011456 Walker A/P-loop; other site 205918011457 ATP binding site [chemical binding]; other site 205918011458 Q-loop/lid; other site 205918011459 ABC transporter signature motif; other site 205918011460 Walker B; other site 205918011461 D-loop; other site 205918011462 H-loop/switch region; other site 205918011463 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011464 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011465 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011466 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011467 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011468 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011469 Condensation domain; Region: Condensation; pfam00668 205918011470 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011471 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011472 acyl-activating enzyme (AAE) consensus motif; other site 205918011473 AMP binding site [chemical binding]; other site 205918011474 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011475 Condensation domain; Region: Condensation; pfam00668 205918011476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011477 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011478 acyl-activating enzyme (AAE) consensus motif; other site 205918011479 AMP binding site [chemical binding]; other site 205918011480 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011481 Condensation domain; Region: Condensation; pfam00668 205918011482 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011483 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918011484 acyl-activating enzyme (AAE) consensus motif; other site 205918011485 AMP binding site [chemical binding]; other site 205918011486 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011487 Condensation domain; Region: Condensation; pfam00668 205918011488 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011489 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011490 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011491 acyl-activating enzyme (AAE) consensus motif; other site 205918011492 AMP binding site [chemical binding]; other site 205918011493 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011494 Condensation domain; Region: Condensation; pfam00668 205918011495 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 205918011496 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011497 acyl-activating enzyme (AAE) consensus motif; other site 205918011498 AMP binding site [chemical binding]; other site 205918011499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011500 Condensation domain; Region: Condensation; pfam00668 205918011501 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 205918011502 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011503 acyl-activating enzyme (AAE) consensus motif; other site 205918011504 AMP binding site [chemical binding]; other site 205918011505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011506 Condensation domain; Region: Condensation; pfam00668 205918011507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011508 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011509 acyl-activating enzyme (AAE) consensus motif; other site 205918011510 AMP binding site [chemical binding]; other site 205918011511 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011512 Condensation domain; Region: Condensation; pfam00668 205918011513 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918011514 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011515 acyl-activating enzyme (AAE) consensus motif; other site 205918011516 AMP binding site [chemical binding]; other site 205918011517 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011518 Condensation domain; Region: Condensation; pfam00668 205918011519 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011520 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011521 acyl-activating enzyme (AAE) consensus motif; other site 205918011522 AMP binding site [chemical binding]; other site 205918011523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011524 Condensation domain; Region: Condensation; pfam00668 205918011525 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011526 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011527 acyl-activating enzyme (AAE) consensus motif; other site 205918011528 AMP binding site [chemical binding]; other site 205918011529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011530 Condensation domain; Region: Condensation; pfam00668 205918011531 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011532 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918011533 acyl-activating enzyme (AAE) consensus motif; other site 205918011534 AMP binding site [chemical binding]; other site 205918011535 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011536 Condensation domain; Region: Condensation; pfam00668 205918011537 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011538 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011539 acyl-activating enzyme (AAE) consensus motif; other site 205918011540 AMP binding site [chemical binding]; other site 205918011541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011542 Condensation domain; Region: Condensation; pfam00668 205918011543 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011544 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011545 acyl-activating enzyme (AAE) consensus motif; other site 205918011546 AMP binding site [chemical binding]; other site 205918011547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011548 Condensation domain; Region: Condensation; pfam00668 205918011549 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011550 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011551 acyl-activating enzyme (AAE) consensus motif; other site 205918011552 AMP binding site [chemical binding]; other site 205918011553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011554 Condensation domain; Region: Condensation; pfam00668 205918011555 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011556 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011557 acyl-activating enzyme (AAE) consensus motif; other site 205918011558 AMP binding site [chemical binding]; other site 205918011559 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011560 Condensation domain; Region: Condensation; pfam00668 205918011561 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011562 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011563 acyl-activating enzyme (AAE) consensus motif; other site 205918011564 AMP binding site [chemical binding]; other site 205918011565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011566 Condensation domain; Region: Condensation; pfam00668 205918011567 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011568 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011569 acyl-activating enzyme (AAE) consensus motif; other site 205918011570 AMP binding site [chemical binding]; other site 205918011571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011572 Condensation domain; Region: Condensation; pfam00668 205918011573 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011574 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011575 acyl-activating enzyme (AAE) consensus motif; other site 205918011576 AMP binding site [chemical binding]; other site 205918011577 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011578 Condensation domain; Region: Condensation; pfam00668 205918011579 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011580 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918011581 acyl-activating enzyme (AAE) consensus motif; other site 205918011582 AMP binding site [chemical binding]; other site 205918011583 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011584 Condensation domain; Region: Condensation; pfam00668 205918011585 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011586 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011587 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011588 acyl-activating enzyme (AAE) consensus motif; other site 205918011589 AMP binding site [chemical binding]; other site 205918011590 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011591 Condensation domain; Region: Condensation; pfam00668 205918011592 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918011593 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011594 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918011595 acyl-activating enzyme (AAE) consensus motif; other site 205918011596 AMP binding site [chemical binding]; other site 205918011597 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011598 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 205918011599 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011600 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918011601 acyl-activating enzyme (AAE) consensus motif; other site 205918011602 AMP binding site [chemical binding]; other site 205918011603 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918011604 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011605 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011606 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918011607 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918011608 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918011609 1 probable transmembrane helix predicted by TMHMM2.0 205918011610 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 205918011611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205918011612 Walker A/P-loop; other site 205918011613 ATP binding site [chemical binding]; other site 205918011614 Q-loop/lid; other site 205918011615 ABC transporter signature motif; other site 205918011616 Walker B; other site 205918011617 D-loop; other site 205918011618 H-loop/switch region; other site 205918011619 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918011620 FtsX-like permease family; Region: FtsX; pfam02687 205918011621 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011622 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011623 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011624 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011625 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011626 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918011627 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 205918011628 inhibitor-cofactor binding pocket; inhibition site 205918011629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011630 catalytic residue [active] 205918011631 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918011632 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918011633 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918011634 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918011635 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011636 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011637 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011638 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011639 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011640 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011641 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011642 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011643 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011644 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011645 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011646 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011647 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918011648 metal ion-dependent adhesion site (MIDAS); other site 205918011649 1 probable transmembrane helix predicted by TMHMM2.0 205918011650 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918011651 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 205918011652 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011653 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011654 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 205918011655 1 probable transmembrane helix predicted by TMHMM2.0 205918011656 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011657 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011658 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205918011660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918011661 Walker A/P-loop; other site 205918011662 ATP binding site [chemical binding]; other site 205918011663 Q-loop/lid; other site 205918011664 ABC transporter signature motif; other site 205918011665 Walker B; other site 205918011666 D-loop; other site 205918011667 H-loop/switch region; other site 205918011668 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205918011669 metal ion-dependent adhesion site (MIDAS); other site 205918011670 1 probable transmembrane helix predicted by TMHMM2.0 205918011671 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 205918011672 Virulence factor SrfB; Region: SrfB; pfam07520 205918011673 1 probable transmembrane helix predicted by TMHMM2.0 205918011674 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918011675 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 205918011676 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918011677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918011678 dimerization interface [polypeptide binding]; other site 205918011679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918011680 dimer interface [polypeptide binding]; other site 205918011681 putative CheW interface [polypeptide binding]; other site 205918011682 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011683 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011684 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 205918011685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 205918011686 TspO/MBR family; Region: TspO_MBR; pfam03073 205918011687 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011688 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011689 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011690 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011691 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011692 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918011693 hydroxyglutarate oxidase; Provisional; Region: PRK11728 205918011694 1 probable transmembrane helix predicted by TMHMM2.0 205918011695 hypothetical protein; Provisional; Region: PRK06489 205918011696 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 205918011697 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 205918011698 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011699 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011700 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011701 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011702 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 205918011703 nudix motif; other site 205918011704 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 205918011705 active site 205918011706 substrate binding site [chemical binding]; other site 205918011707 ATP binding site [chemical binding]; other site 205918011708 AAA domain; Region: AAA_13; pfam13166 205918011709 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 205918011710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918011711 FeS/SAM binding site; other site 205918011712 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 205918011713 HEXXH motif domain; Region: mod_HExxH; TIGR04267 205918011714 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205918011715 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918011716 Methyltransferase domain; Region: Methyltransf_26; pfam13659 205918011717 S-adenosylmethionine binding site [chemical binding]; other site 205918011718 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 205918011719 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205918011720 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 205918011721 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011722 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011723 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918011725 Transposase; Region: HTH_Tnp_1; cl17663 205918011726 putative transposase OrfB; Reviewed; Region: PHA02517 205918011727 HTH-like domain; Region: HTH_21; pfam13276 205918011728 Integrase core domain; Region: rve; pfam00665 205918011729 Integrase core domain; Region: rve_2; pfam13333 205918011730 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 205918011731 dimer interface [polypeptide binding]; other site 205918011732 FMN binding site [chemical binding]; other site 205918011733 NADPH bind site [chemical binding]; other site 205918011734 Abortive infection C-terminus; Region: Abi_C; pfam14355 205918011735 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 205918011736 Restriction endonuclease; Region: Mrr_cat; pfam04471 205918011737 Domain of unknown function (DUF955); Region: DUF955; pfam06114 205918011738 putative alcohol dehydrogenase; Provisional; Region: PRK09860 205918011739 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011740 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011741 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918011742 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918011743 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 205918011744 nudix motif; other site 205918011745 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 205918011746 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 205918011747 multiple promoter invertase; Provisional; Region: mpi; PRK13413 205918011748 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 205918011749 catalytic residues [active] 205918011750 catalytic nucleophile [active] 205918011751 Presynaptic Site I dimer interface [polypeptide binding]; other site 205918011752 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 205918011753 Synaptic Flat tetramer interface [polypeptide binding]; other site 205918011754 Synaptic Site I dimer interface [polypeptide binding]; other site 205918011755 DNA binding site [nucleotide binding] 205918011756 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 205918011757 DNA-binding interface [nucleotide binding]; DNA binding site 205918011758 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 205918011759 Phosphotransferase enzyme family; Region: APH; pfam01636 205918011760 active site 205918011761 ATP binding site [chemical binding]; other site 205918011762 antibiotic binding site [chemical binding]; other site 205918011763 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 205918011764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918011765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918011766 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 205918011767 putative dimerization interface [polypeptide binding]; other site 205918011768 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 205918011769 Citrate transporter; Region: CitMHS; pfam03600 205918011770 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011771 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011772 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011773 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011774 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011775 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011776 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011777 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011778 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011779 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011780 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011781 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 205918011782 transcriptional regulator NanR; Provisional; Region: PRK03837 205918011783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918011784 DNA-binding site [nucleotide binding]; DNA binding site 205918011785 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 205918011786 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918011787 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918011788 Walker A/P-loop; other site 205918011789 ATP binding site [chemical binding]; other site 205918011790 Q-loop/lid; other site 205918011791 ABC transporter signature motif; other site 205918011792 Walker B; other site 205918011793 D-loop; other site 205918011794 H-loop/switch region; other site 205918011795 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 205918011796 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918011797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918011798 Walker A/P-loop; other site 205918011799 ATP binding site [chemical binding]; other site 205918011800 Q-loop/lid; other site 205918011801 ABC transporter signature motif; other site 205918011802 Walker B; other site 205918011803 D-loop; other site 205918011804 H-loop/switch region; other site 205918011805 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 205918011806 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918011807 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 205918011808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918011809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011810 dimer interface [polypeptide binding]; other site 205918011811 conserved gate region; other site 205918011812 putative PBP binding loops; other site 205918011813 ABC-ATPase subunit interface; other site 205918011814 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011815 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011816 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011817 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011818 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011819 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011820 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918011821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011822 dimer interface [polypeptide binding]; other site 205918011823 conserved gate region; other site 205918011824 putative PBP binding loops; other site 205918011825 ABC-ATPase subunit interface; other site 205918011826 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011827 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011828 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011829 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011830 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 205918011831 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 205918011832 Cache domain; Region: Cache_1; pfam02743 205918011833 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918011834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918011835 dimerization interface [polypeptide binding]; other site 205918011836 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918011837 dimer interface [polypeptide binding]; other site 205918011838 putative CheW interface [polypeptide binding]; other site 205918011839 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011840 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011841 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 205918011842 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011843 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011844 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011845 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011846 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011847 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011848 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011849 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011850 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011851 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011852 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011853 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011854 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011855 arginine deiminase; Provisional; Region: PRK01388 205918011856 ornithine carbamoyltransferase; Validated; Region: PRK02102 205918011857 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205918011858 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205918011859 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 205918011860 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 205918011861 putative substrate binding site [chemical binding]; other site 205918011862 nucleotide binding site [chemical binding]; other site 205918011863 nucleotide binding site [chemical binding]; other site 205918011864 homodimer interface [polypeptide binding]; other site 205918011865 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918011866 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 205918011867 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 205918011868 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 205918011869 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011870 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011871 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011872 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011873 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011874 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011875 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011876 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 205918011877 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 205918011878 inhibitor-cofactor binding pocket; inhibition site 205918011879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011880 catalytic residue [active] 205918011881 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 205918011882 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 205918011883 Ligand binding site; other site 205918011884 Putative Catalytic site; other site 205918011885 DXD motif; other site 205918011886 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011887 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011888 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 205918011889 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 205918011890 active site 205918011891 substrate binding site [chemical binding]; other site 205918011892 cosubstrate binding site; other site 205918011893 catalytic site [active] 205918011894 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 205918011895 active site 205918011896 hexamer interface [polypeptide binding]; other site 205918011897 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 205918011898 NAD binding site [chemical binding]; other site 205918011899 substrate binding site [chemical binding]; other site 205918011900 active site 205918011901 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 205918011902 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 205918011903 putative active site [active] 205918011904 putative catalytic site [active] 205918011905 putative Zn binding site [ion binding]; other site 205918011906 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 205918011907 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 205918011908 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011909 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011910 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011911 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011912 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011913 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011914 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011915 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011916 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011917 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011918 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011919 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 205918011920 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011921 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011922 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011923 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 205918011924 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011925 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011926 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011927 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011928 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 205918011929 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 205918011930 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 205918011931 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 205918011932 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 205918011933 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 205918011934 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011935 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011936 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011937 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011938 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011939 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011940 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011941 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011942 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011943 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 205918011944 putative sugar binding sites [chemical binding]; other site 205918011945 Q-X-W motif; other site 205918011946 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 205918011947 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 205918011948 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 205918011949 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011950 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011951 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011952 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011953 histidine kinase; Provisional; Region: PRK13557 205918011954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918011955 putative active site [active] 205918011956 heme pocket [chemical binding]; other site 205918011957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918011958 dimer interface [polypeptide binding]; other site 205918011959 phosphorylation site [posttranslational modification] 205918011960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918011961 ATP binding site [chemical binding]; other site 205918011962 Mg2+ binding site [ion binding]; other site 205918011963 G-X-G motif; other site 205918011964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918011965 active site 205918011966 phosphorylation site [posttranslational modification] 205918011967 intermolecular recognition site; other site 205918011968 dimerization interface [polypeptide binding]; other site 205918011969 beta-galactosidase; Region: BGL; TIGR03356 205918011970 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 205918011971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918011972 UDP-galactopyranose mutase; Region: GLF; pfam03275 205918011973 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 205918011974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918011975 putative homodimer interface [polypeptide binding]; other site 205918011976 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 205918011977 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 205918011978 NAD binding site [chemical binding]; other site 205918011979 homodimer interface [polypeptide binding]; other site 205918011980 active site 205918011981 substrate binding site [chemical binding]; other site 205918011982 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 205918011983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918011984 non-specific DNA binding site [nucleotide binding]; other site 205918011985 salt bridge; other site 205918011986 sequence-specific DNA binding site [nucleotide binding]; other site 205918011987 Cupin domain; Region: Cupin_2; pfam07883 205918011988 Peptidase C26; Region: Peptidase_C26; pfam07722 205918011989 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 205918011990 catalytic triad [active] 205918011991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918011992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918011993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918011994 dimerization interface [polypeptide binding]; other site 205918011995 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 205918011996 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 205918011997 iron-sulfur cluster [ion binding]; other site 205918011998 [2Fe-2S] cluster binding site [ion binding]; other site 205918011999 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 205918012000 alpha subunit interface [polypeptide binding]; other site 205918012001 active site 205918012002 substrate binding site [chemical binding]; other site 205918012003 Fe binding site [ion binding]; other site 205918012004 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 205918012005 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 205918012006 FMN-binding pocket [chemical binding]; other site 205918012007 flavin binding motif; other site 205918012008 phosphate binding motif [ion binding]; other site 205918012009 beta-alpha-beta structure motif; other site 205918012010 NAD binding pocket [chemical binding]; other site 205918012011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918012012 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 205918012013 catalytic loop [active] 205918012014 iron binding site [ion binding]; other site 205918012015 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918012016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918012017 DNA-binding site [nucleotide binding]; DNA binding site 205918012018 FCD domain; Region: FCD; pfam07729 205918012019 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 205918012020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918012021 metal binding site [ion binding]; metal-binding site 205918012022 active site 205918012023 I-site; other site 205918012024 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918012025 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012026 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012027 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012028 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012029 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012030 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 205918012031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012032 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 205918012033 putative dimerization interface [polypeptide binding]; other site 205918012034 putative substrate binding pocket [chemical binding]; other site 205918012035 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 205918012036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918012037 D-galactonate transporter; Region: 2A0114; TIGR00893 205918012038 putative substrate translocation pore; other site 205918012039 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012040 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012041 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012042 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012043 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012044 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012045 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012046 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012047 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012048 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012049 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012050 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012051 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 205918012052 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 205918012053 active site 205918012054 tetramer interface [polypeptide binding]; other site 205918012055 Uncharacterized conserved protein [Function unknown]; Region: COG1359 205918012056 Major royal jelly protein; Region: MRJP; pfam03022 205918012057 1 probable transmembrane helix predicted by TMHMM2.0 205918012058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918012059 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 205918012060 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 205918012061 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 205918012062 1 probable transmembrane helix predicted by TMHMM2.0 205918012063 hypothetical protein; Provisional; Region: PRK12569 205918012064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012066 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 205918012067 putative substrate binding pocket [chemical binding]; other site 205918012068 dimerization interface [polypeptide binding]; other site 205918012069 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 205918012070 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918012071 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 205918012072 dimer interface [polypeptide binding]; other site 205918012073 active site 205918012074 feruloyl-CoA synthase; Reviewed; Region: PRK08180 205918012075 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 205918012076 acyl-activating enzyme (AAE) consensus motif; other site 205918012077 putative AMP binding site [chemical binding]; other site 205918012078 putative active site [active] 205918012079 putative CoA binding site [chemical binding]; other site 205918012080 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918012081 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 205918012082 NAD(P) binding site [chemical binding]; other site 205918012083 catalytic residues [active] 205918012084 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 205918012085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918012086 substrate binding site [chemical binding]; other site 205918012087 oxyanion hole (OAH) forming residues; other site 205918012088 trimer interface [polypeptide binding]; other site 205918012089 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 205918012090 domain I; other site 205918012091 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918012092 MarR family; Region: MarR_2; pfam12802 205918012093 phosphate binding site [ion binding]; other site 205918012094 outer membrane porin, OprD family; Region: OprD; pfam03573 205918012095 benzoate transport; Region: 2A0115; TIGR00895 205918012096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918012097 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012098 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012099 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012100 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012101 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012102 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012103 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012104 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012105 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012106 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012107 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012108 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012109 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 205918012110 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 205918012111 NAD(P) binding site [chemical binding]; other site 205918012112 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 205918012113 active site 205918012114 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918012115 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 205918012116 NAD(P) binding site [chemical binding]; other site 205918012117 catalytic residues [active] 205918012118 Activator of aromatic catabolism; Region: XylR_N; pfam06505 205918012119 V4R domain; Region: V4R; pfam02830 205918012120 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 205918012121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918012122 Walker A motif; other site 205918012123 ATP binding site [chemical binding]; other site 205918012124 Walker B motif; other site 205918012125 arginine finger; other site 205918012126 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 205918012127 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 205918012128 trehalose synthase; Region: treS_nterm; TIGR02456 205918012129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918012131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012133 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 205918012134 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 205918012135 conserved cys residue [active] 205918012136 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 205918012137 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 205918012138 conserved cys residue [active] 205918012139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918012140 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918012141 Beta-lactamase; Region: Beta-lactamase; pfam00144 205918012142 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 205918012143 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 205918012144 putative active site [active] 205918012145 metal binding site [ion binding]; metal-binding site 205918012146 LysE type translocator; Region: LysE; cl00565 205918012147 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012148 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012149 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012150 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012151 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 205918012152 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 205918012153 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205918012154 dimer interface [polypeptide binding]; other site 205918012155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918012156 catalytic residue [active] 205918012157 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 205918012158 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 205918012159 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 205918012160 NAD(P) binding pocket [chemical binding]; other site 205918012161 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 205918012162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918012163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918012164 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 205918012165 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 205918012166 ligand binding site [chemical binding]; other site 205918012167 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918012168 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 205918012169 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918012170 active site 205918012171 nucleotide binding site [chemical binding]; other site 205918012172 HIGH motif; other site 205918012173 KMSKS motif; other site 205918012174 Cupin domain; Region: Cupin_2; pfam07883 205918012175 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918012176 active site 205918012177 DNA binding site [nucleotide binding] 205918012178 Int/Topo IB signature motif; other site 205918012179 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 205918012180 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 205918012181 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 205918012182 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 205918012183 NADP binding site [chemical binding]; other site 205918012184 dimer interface [polypeptide binding]; other site 205918012185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918012186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918012187 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 205918012188 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 205918012189 FMN binding site [chemical binding]; other site 205918012190 substrate binding site [chemical binding]; other site 205918012191 putative catalytic residue [active] 205918012192 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918012193 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205918012194 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205918012195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012196 dimer interface [polypeptide binding]; other site 205918012197 conserved gate region; other site 205918012198 putative PBP binding loops; other site 205918012199 ABC-ATPase subunit interface; other site 205918012200 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012201 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012202 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012203 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012204 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012205 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 205918012206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918012207 Walker A/P-loop; other site 205918012208 ATP binding site [chemical binding]; other site 205918012209 Q-loop/lid; other site 205918012210 ABC transporter signature motif; other site 205918012211 Walker B; other site 205918012212 D-loop; other site 205918012213 H-loop/switch region; other site 205918012214 TOBE domain; Region: TOBE; cl01440 205918012215 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 205918012216 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 205918012217 active site 205918012218 DNA binding site [nucleotide binding] 205918012219 Int/Topo IB signature motif; other site 205918012220 catalytic residues [active] 205918012221 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 205918012222 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 205918012223 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 205918012224 active site 205918012225 DNA binding site [nucleotide binding] 205918012226 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 205918012227 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918012228 Catalytic site [active] 205918012229 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918012230 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 205918012231 active site 205918012232 catalytic triad [active] 205918012233 oxyanion hole [active] 205918012234 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 205918012235 1 probable transmembrane helix predicted by TMHMM2.0 205918012236 Predicted chitinase [General function prediction only]; Region: COG3179 205918012237 catalytic residue [active] 205918012238 Phage-related protein, tail component [Function unknown]; Region: COG4733 205918012239 Putative phage tail protein; Region: Phage-tail_3; pfam13550 205918012240 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 205918012241 Phage-related protein, tail component [Function unknown]; Region: COG4723 205918012242 1 probable transmembrane helix predicted by TMHMM2.0 205918012243 1 probable transmembrane helix predicted by TMHMM2.0 205918012244 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 205918012245 MPN+ (JAMM) motif; other site 205918012246 Zinc-binding site [ion binding]; other site 205918012247 NlpC/P60 family; Region: NLPC_P60; cl17555 205918012248 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 205918012249 Phage-related protein [Function unknown]; Region: gp18; COG4672 205918012250 Phage minor tail protein; Region: Phage_min_tail; pfam05939 205918012251 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 205918012252 Phage-related minor tail protein [Function unknown]; Region: COG5281 205918012253 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 205918012254 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 205918012255 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 205918012256 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 205918012257 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 205918012258 Phage tail protein; Region: Phage_tail_3; pfam08813 205918012259 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 205918012260 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 205918012261 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 205918012262 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 205918012263 Phage terminase large subunit; Region: Terminase_3; cl12054 205918012264 Terminase-like family; Region: Terminase_6; pfam03237 205918012265 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 205918012266 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918012267 active site 205918012268 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012269 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012270 1 probable transmembrane helix predicted by TMHMM2.0 205918012271 seryl-tRNA synthetase; Provisional; Region: PRK05431 205918012272 1 probable transmembrane helix predicted by TMHMM2.0 205918012273 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012274 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012275 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 205918012276 NinB protein; Region: NinB; pfam05772 205918012277 NAD-dependent deacetylase; Provisional; Region: PRK14138 205918012278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918012279 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 205918012280 non-specific DNA binding site [nucleotide binding]; other site 205918012281 salt bridge; other site 205918012282 sequence-specific DNA binding site [nucleotide binding]; other site 205918012283 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918012284 Catalytic site [active] 205918012285 1 probable transmembrane helix predicted by TMHMM2.0 205918012286 Virulence protein [General function prediction only]; Region: COG3943 205918012287 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 205918012288 RecT family; Region: RecT; pfam03837 205918012289 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 205918012290 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 205918012291 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 205918012292 DNA methylase; Region: N6_N4_Mtase; pfam01555 205918012293 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 205918012294 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 205918012295 Active Sites [active] 205918012296 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 205918012297 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205918012298 substrate interaction site [chemical binding]; other site 205918012299 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205918012300 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 205918012301 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918012302 active site 205918012303 DNA binding site [nucleotide binding] 205918012304 Int/Topo IB signature motif; other site 205918012305 conserved hypothetical protein 205918012306 1 probable transmembrane helix predicted by TMHMM2.0 205918012307 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012308 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012309 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 205918012310 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 205918012311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918012312 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 205918012313 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205918012314 substrate interaction site [chemical binding]; other site 205918012315 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205918012316 phytoene desaturase; Region: crtI_fam; TIGR02734 205918012317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918012318 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918012319 active site 205918012320 DNA binding site [nucleotide binding] 205918012321 Int/Topo IB signature motif; other site 205918012322 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 205918012323 hypothetical protein 205918012324 1 probable transmembrane helix predicted by TMHMM2.0 205918012325 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 205918012326 hypothetical protein 205918012327 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 205918012328 methionine synthase; Provisional; Region: PRK01207 205918012329 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 205918012330 substrate binding site [chemical binding]; other site 205918012331 THF binding site; other site 205918012332 zinc-binding site [ion binding]; other site 205918012333 Chitin binding domain; Region: Chitin_bind_3; pfam03067 205918012334 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 205918012335 active site 205918012336 oxidase reductase; Provisional; Region: PTZ00273 205918012337 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 205918012338 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 205918012339 Isochorismatase family; Region: Isochorismatase; pfam00857 205918012340 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918012341 catalytic triad [active] 205918012342 conserved cis-peptide bond; other site 205918012343 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 205918012344 GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species; Region: GYF; cl00072 205918012345 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 205918012346 Cytochrome c; Region: Cytochrom_C; pfam00034 205918012347 Tannase and feruloyl esterase; Region: Tannase; pfam07519 205918012348 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 205918012349 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 205918012350 Protein export membrane protein; Region: SecD_SecF; cl14618 205918012351 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012352 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012353 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012354 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012355 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012356 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012357 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012358 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012359 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012360 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012361 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012362 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 205918012363 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918012364 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918012365 1 probable transmembrane helix predicted by TMHMM2.0 205918012366 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 205918012367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918012368 dimerization interface [polypeptide binding]; other site 205918012369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918012370 dimer interface [polypeptide binding]; other site 205918012371 phosphorylation site [posttranslational modification] 205918012372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918012373 ATP binding site [chemical binding]; other site 205918012374 Mg2+ binding site [ion binding]; other site 205918012375 G-X-G motif; other site 205918012376 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012377 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012378 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 205918012379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012380 active site 205918012381 phosphorylation site [posttranslational modification] 205918012382 intermolecular recognition site; other site 205918012383 dimerization interface [polypeptide binding]; other site 205918012384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918012385 DNA binding site [nucleotide binding] 205918012386 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918012387 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918012388 active site 205918012389 non-prolyl cis peptide bond; other site 205918012390 acyl-CoA dehydrogenase 205918012391 Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, N-terminal 205918012392 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 205918012393 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 205918012394 Flavin binding site [chemical binding]; other site 205918012395 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918012396 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918012397 TM-ABC transporter signature motif; other site 205918012398 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012399 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012400 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012401 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012402 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012403 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012404 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012405 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012406 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012407 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918012408 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918012409 TM-ABC transporter signature motif; other site 205918012410 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012411 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012412 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012413 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012414 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012415 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012416 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012417 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012418 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012419 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918012420 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918012421 Walker A/P-loop; other site 205918012422 ATP binding site [chemical binding]; other site 205918012423 Q-loop/lid; other site 205918012424 ABC transporter signature motif; other site 205918012425 Walker B; other site 205918012426 D-loop; other site 205918012427 H-loop/switch region; other site 205918012428 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918012429 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 205918012430 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918012431 putative ligand binding site [chemical binding]; other site 205918012432 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918012433 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918012434 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918012435 dimer interface [polypeptide binding]; other site 205918012436 putative CheW interface [polypeptide binding]; other site 205918012437 1 probable transmembrane helix predicted by TMHMM2.0 205918012438 VirK protein; Region: VirK; pfam06903 205918012439 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 205918012440 active site 205918012441 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 205918012442 putative dimerization interface [polypeptide binding]; other site 205918012443 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918012444 putative ligand binding site [chemical binding]; other site 205918012445 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918012446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918012447 xylose isomerase; Provisional; Region: PRK05474 205918012448 xylose isomerase; Region: xylose_isom_A; TIGR02630 205918012449 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 205918012450 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 205918012451 putative ligand binding site [chemical binding]; other site 205918012452 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 205918012453 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918012454 Walker A/P-loop; other site 205918012455 ATP binding site [chemical binding]; other site 205918012456 Q-loop/lid; other site 205918012457 ABC transporter signature motif; other site 205918012458 Walker B; other site 205918012459 D-loop; other site 205918012460 H-loop/switch region; other site 205918012461 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918012462 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918012463 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918012464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918012465 TM-ABC transporter signature motif; other site 205918012466 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012467 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012468 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012469 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012470 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012471 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012472 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012473 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012474 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012475 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918012476 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 205918012477 homotrimer interaction site [polypeptide binding]; other site 205918012478 putative active site [active] 205918012479 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 205918012480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918012481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918012482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918012483 substrate binding pocket [chemical binding]; other site 205918012484 membrane-bound complex binding site; other site 205918012485 hinge residues; other site 205918012486 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918012487 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918012488 Walker A/P-loop; other site 205918012489 ATP binding site [chemical binding]; other site 205918012490 Q-loop/lid; other site 205918012491 ABC transporter signature motif; other site 205918012492 Walker B; other site 205918012493 D-loop; other site 205918012494 H-loop/switch region; other site 205918012495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012497 dimer interface [polypeptide binding]; other site 205918012498 conserved gate region; other site 205918012499 putative PBP binding loops; other site 205918012500 ABC-ATPase subunit interface; other site 205918012501 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012502 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012503 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012504 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012505 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012506 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 205918012507 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918012508 N-terminal plug; other site 205918012509 ligand-binding site [chemical binding]; other site 205918012510 1 probable transmembrane helix predicted by TMHMM2.0 205918012511 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 205918012512 Protein of unknown function, DUF393; Region: DUF393; pfam04134 205918012513 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205918012514 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012515 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012516 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012517 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012518 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 205918012519 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 205918012520 GIY-YIG motif/motif A; other site 205918012521 active site 205918012522 catalytic site [active] 205918012523 putative DNA binding site [nucleotide binding]; other site 205918012524 metal binding site [ion binding]; metal-binding site 205918012525 UvrB/uvrC motif; Region: UVR; pfam02151 205918012526 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 205918012527 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 205918012528 DNA binding site [nucleotide binding] 205918012529 response regulator; Provisional; Region: PRK09483 205918012530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012531 active site 205918012532 phosphorylation site [posttranslational modification] 205918012533 intermolecular recognition site; other site 205918012534 dimerization interface [polypeptide binding]; other site 205918012535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918012536 DNA binding residues [nucleotide binding] 205918012537 dimerization interface [polypeptide binding]; other site 205918012538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918012539 non-specific DNA binding site [nucleotide binding]; other site 205918012540 salt bridge; other site 205918012541 sequence-specific DNA binding site [nucleotide binding]; other site 205918012542 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 205918012543 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 205918012544 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205918012545 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 205918012546 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918012547 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918012548 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 205918012549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012550 dimer interface [polypeptide binding]; other site 205918012551 conserved gate region; other site 205918012552 putative PBP binding loops; other site 205918012553 ABC-ATPase subunit interface; other site 205918012554 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012555 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012556 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012557 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012558 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012559 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012560 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 205918012561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012562 dimer interface [polypeptide binding]; other site 205918012563 conserved gate region; other site 205918012564 putative PBP binding loops; other site 205918012565 ABC-ATPase subunit interface; other site 205918012566 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012567 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012568 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012569 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012570 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012571 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012572 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 205918012573 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918012574 Walker A/P-loop; other site 205918012575 ATP binding site [chemical binding]; other site 205918012576 Q-loop/lid; other site 205918012577 ABC transporter signature motif; other site 205918012578 Walker B; other site 205918012579 D-loop; other site 205918012580 H-loop/switch region; other site 205918012581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918012583 Walker A/P-loop; other site 205918012584 ATP binding site [chemical binding]; other site 205918012585 Q-loop/lid; other site 205918012586 ABC transporter signature motif; other site 205918012587 Walker B; other site 205918012588 D-loop; other site 205918012589 H-loop/switch region; other site 205918012590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012591 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 205918012592 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205918012593 Walker A motif; other site 205918012594 ATP binding site [chemical binding]; other site 205918012595 Walker B motif; other site 205918012596 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 205918012597 phosphoglucomutase; Validated; Region: PRK07564 205918012598 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 205918012599 active site 205918012600 substrate binding site [chemical binding]; other site 205918012601 metal binding site [ion binding]; metal-binding site 205918012602 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 205918012603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 205918012604 DEAD_2; Region: DEAD_2; pfam06733 205918012605 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 205918012606 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918012607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918012608 DNA-binding site [nucleotide binding]; DNA binding site 205918012609 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918012610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918012611 catalytic residue [active] 205918012612 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 205918012613 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918012614 putative NAD(P) binding site [chemical binding]; other site 205918012615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012617 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 205918012618 putative substrate binding pocket [chemical binding]; other site 205918012619 putative dimerization interface [polypeptide binding]; other site 205918012620 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 205918012621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918012622 ATP binding site [chemical binding]; other site 205918012623 putative Mg++ binding site [ion binding]; other site 205918012624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918012625 nucleotide binding region [chemical binding]; other site 205918012626 ATP-binding site [chemical binding]; other site 205918012627 Part of AAA domain; Region: AAA_19; pfam13245 205918012628 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205918012629 Family description; Region: UvrD_C_2; pfam13538 205918012630 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918012631 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 205918012632 conserved cys residue [active] 205918012633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918012634 1 probable transmembrane helix predicted by TMHMM2.0 205918012635 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 205918012636 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 205918012637 Uncharacterized conserved protein [Function unknown]; Region: COG3246 205918012638 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 205918012639 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 205918012640 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205918012641 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918012642 active site 205918012643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918012644 DNA-binding site [nucleotide binding]; DNA binding site 205918012645 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205918012646 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 205918012647 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 205918012648 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918012649 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 205918012650 Na binding site [ion binding]; other site 205918012651 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012652 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012653 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012654 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012655 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012656 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012657 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012658 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012659 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012660 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012661 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012662 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012663 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 205918012664 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918012665 substrate binding site [chemical binding]; other site 205918012666 ATP binding site [chemical binding]; other site 205918012667 HipA N-terminal domain; Region: Couple_hipA; pfam13657 205918012668 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205918012669 HipA-like C-terminal domain; Region: HipA_C; pfam07804 205918012670 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205918012671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918012672 non-specific DNA binding site [nucleotide binding]; other site 205918012673 salt bridge; other site 205918012674 sequence-specific DNA binding site [nucleotide binding]; other site 205918012675 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205918012676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918012677 putative substrate translocation pore; other site 205918012678 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012679 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012680 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012681 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012682 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012683 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012684 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012685 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012686 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012687 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012688 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012689 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918012691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918012692 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918012693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918012694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918012695 Walker A/P-loop; other site 205918012696 ATP binding site [chemical binding]; other site 205918012697 Q-loop/lid; other site 205918012698 ABC transporter signature motif; other site 205918012699 Walker B; other site 205918012700 D-loop; other site 205918012701 H-loop/switch region; other site 205918012702 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012703 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012704 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012705 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012706 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012709 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 205918012710 putative dimerization interface [polypeptide binding]; other site 205918012711 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 205918012712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918012713 putative metal binding site [ion binding]; other site 205918012714 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 205918012715 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012716 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012717 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012718 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012719 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012720 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012721 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 205918012722 putative homodimer interface [polypeptide binding]; other site 205918012723 putative homotetramer interface [polypeptide binding]; other site 205918012724 putative metal binding site [ion binding]; other site 205918012725 putative homodimer-homodimer interface [polypeptide binding]; other site 205918012726 putative allosteric switch controlling residues; other site 205918012727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918012728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918012729 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918012730 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 205918012731 FMN binding site [chemical binding]; other site 205918012732 active site 205918012733 substrate binding site [chemical binding]; other site 205918012734 catalytic residue [active] 205918012735 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 205918012736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918012737 NADH(P)-binding; Region: NAD_binding_10; pfam13460 205918012738 NAD(P) binding site [chemical binding]; other site 205918012739 active site 205918012740 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918012741 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 205918012742 active site 205918012743 FMN binding site [chemical binding]; other site 205918012744 substrate binding site [chemical binding]; other site 205918012745 putative catalytic residue [active] 205918012746 D-serine deaminase transcriptional activator; Region: dsdC; TIGR02036 205918012747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012748 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918012749 putative effector binding pocket; other site 205918012750 dimerization interface [polypeptide binding]; other site 205918012751 Response regulator receiver domain; Region: Response_reg; pfam00072 205918012752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012753 active site 205918012754 phosphorylation site [posttranslational modification] 205918012755 intermolecular recognition site; other site 205918012756 dimerization interface [polypeptide binding]; other site 205918012757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918012758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918012759 metal binding site [ion binding]; metal-binding site 205918012760 active site 205918012761 I-site; other site 205918012762 CHASE domain; Region: CHASE; pfam03924 205918012763 PAS domain S-box; Region: sensory_box; TIGR00229 205918012764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918012765 putative active site [active] 205918012766 heme pocket [chemical binding]; other site 205918012767 PAS domain; Region: PAS_9; pfam13426 205918012768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918012769 putative active site [active] 205918012770 heme pocket [chemical binding]; other site 205918012771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918012772 dimer interface [polypeptide binding]; other site 205918012773 phosphorylation site [posttranslational modification] 205918012774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918012775 ATP binding site [chemical binding]; other site 205918012776 Mg2+ binding site [ion binding]; other site 205918012777 G-X-G motif; other site 205918012778 Response regulator receiver domain; Region: Response_reg; pfam00072 205918012779 Response regulator receiver domain; Region: Response_reg; pfam00072 205918012780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012781 active site 205918012782 phosphorylation site [posttranslational modification] 205918012783 intermolecular recognition site; other site 205918012784 dimerization interface [polypeptide binding]; other site 205918012785 Hpt domain; Region: Hpt; pfam01627 205918012786 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012787 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012788 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205918012789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918012790 substrate binding pocket [chemical binding]; other site 205918012791 membrane-bound complex binding site; other site 205918012792 hinge residues; other site 205918012793 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918012794 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918012795 Walker A/P-loop; other site 205918012796 ATP binding site [chemical binding]; other site 205918012797 Q-loop/lid; other site 205918012798 ABC transporter signature motif; other site 205918012799 Walker B; other site 205918012800 D-loop; other site 205918012801 H-loop/switch region; other site 205918012802 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918012803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012804 dimer interface [polypeptide binding]; other site 205918012805 conserved gate region; other site 205918012806 putative PBP binding loops; other site 205918012807 ABC-ATPase subunit interface; other site 205918012808 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012809 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012810 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012812 dimer interface [polypeptide binding]; other site 205918012813 conserved gate region; other site 205918012814 putative PBP binding loops; other site 205918012815 ABC-ATPase subunit interface; other site 205918012816 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012817 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012818 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012819 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012820 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012823 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 205918012824 putative effector binding pocket; other site 205918012825 putative dimerization interface [polypeptide binding]; other site 205918012826 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 205918012827 active site 1 [active] 205918012828 dimer interface [polypeptide binding]; other site 205918012829 hexamer interface [polypeptide binding]; other site 205918012830 active site 2 [active] 205918012831 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 205918012832 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 205918012833 dimer interface [polypeptide binding]; other site 205918012834 FMN binding site [chemical binding]; other site 205918012835 Uncharacterized conserved protein [Function unknown]; Region: COG2128 205918012836 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918012837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918012839 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918012840 putative effector binding pocket; other site 205918012841 dimerization interface [polypeptide binding]; other site 205918012842 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 205918012843 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 205918012844 1 probable transmembrane helix predicted by TMHMM2.0 205918012845 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 205918012846 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 205918012847 putative active site [active] 205918012848 metal binding site [ion binding]; metal-binding site 205918012849 putative hydrolase; Provisional; Region: PRK11460 205918012850 Predicted membrane protein [Function unknown]; Region: COG2259 205918012851 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012852 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012853 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012854 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012855 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 205918012856 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 205918012857 substrate binding site [chemical binding]; other site 205918012858 catalytic Zn binding site [ion binding]; other site 205918012859 NAD binding site [chemical binding]; other site 205918012860 structural Zn binding site [ion binding]; other site 205918012861 dimer interface [polypeptide binding]; other site 205918012862 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 205918012863 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918012864 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 205918012865 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918012866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012867 dimer interface [polypeptide binding]; other site 205918012868 conserved gate region; other site 205918012869 putative PBP binding loops; other site 205918012870 ABC-ATPase subunit interface; other site 205918012871 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012872 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012873 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012874 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012875 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012876 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205918012878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012879 dimer interface [polypeptide binding]; other site 205918012880 conserved gate region; other site 205918012881 putative PBP binding loops; other site 205918012882 ABC-ATPase subunit interface; other site 205918012883 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012884 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012885 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012886 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012887 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012888 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012889 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205918012890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918012891 Walker A/P-loop; other site 205918012892 ATP binding site [chemical binding]; other site 205918012893 Q-loop/lid; other site 205918012894 ABC transporter signature motif; other site 205918012895 Walker B; other site 205918012896 D-loop; other site 205918012897 H-loop/switch region; other site 205918012898 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 205918012899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918012900 Walker A/P-loop; other site 205918012901 ATP binding site [chemical binding]; other site 205918012902 Q-loop/lid; other site 205918012903 ABC transporter signature motif; other site 205918012904 Walker B; other site 205918012905 D-loop; other site 205918012906 H-loop/switch region; other site 205918012907 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 205918012908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918012909 substrate binding pocket [chemical binding]; other site 205918012910 membrane-bound complex binding site; other site 205918012911 hinge residues; other site 205918012912 1 probable transmembrane helix predicted by TMHMM2.0 205918012913 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918012914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012915 dimer interface [polypeptide binding]; other site 205918012916 conserved gate region; other site 205918012917 putative PBP binding loops; other site 205918012918 ABC-ATPase subunit interface; other site 205918012919 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012920 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012921 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012923 dimer interface [polypeptide binding]; other site 205918012924 conserved gate region; other site 205918012925 putative PBP binding loops; other site 205918012926 ABC-ATPase subunit interface; other site 205918012927 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012928 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012929 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012930 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918012931 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918012932 Walker A/P-loop; other site 205918012933 ATP binding site [chemical binding]; other site 205918012934 Q-loop/lid; other site 205918012935 ABC transporter signature motif; other site 205918012936 Walker B; other site 205918012937 D-loop; other site 205918012938 H-loop/switch region; other site 205918012939 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918012940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918012941 dimerization interface [polypeptide binding]; other site 205918012942 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918012943 dimer interface [polypeptide binding]; other site 205918012944 putative CheW interface [polypeptide binding]; other site 205918012945 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012946 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012947 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918012948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918012949 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918012950 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 205918012951 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012952 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012953 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012954 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012955 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012956 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012957 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012958 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012959 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012960 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012961 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012962 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012963 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 205918012964 HEAT repeats; Region: HEAT_2; pfam13646 205918012965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 205918012966 TPR motif; other site 205918012967 binding surface 205918012968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918012969 binding surface 205918012970 TPR motif; other site 205918012971 TPR repeat; Region: TPR_11; pfam13414 205918012972 1 probable transmembrane helix predicted by TMHMM2.0 205918012973 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 205918012974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918012975 dimer interface [polypeptide binding]; other site 205918012976 active site 205918012977 metal binding site [ion binding]; metal-binding site 205918012978 glutathione binding site [chemical binding]; other site 205918012979 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 205918012980 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 205918012981 catalytic residue [active] 205918012982 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 205918012983 catalytic residues [active] 205918012984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918012985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918012986 peroxiredoxin; Region: AhpC; TIGR03137 205918012987 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 205918012988 dimer interface [polypeptide binding]; other site 205918012989 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205918012990 catalytic triad [active] 205918012991 peroxidatic and resolving cysteines [active] 205918012992 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 205918012993 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 205918012994 DNA binding site [nucleotide binding] 205918012995 dimer interface [polypeptide binding]; other site 205918012996 active site 205918012997 Int/Topo IB signature motif; other site 205918012998 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 205918012999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918013000 PAS domain; Region: PAS_9; pfam13426 205918013001 putative active site [active] 205918013002 heme pocket [chemical binding]; other site 205918013003 histidine kinase; Provisional; Region: PRK13557 205918013004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918013005 ATP binding site [chemical binding]; other site 205918013006 Mg2+ binding site [ion binding]; other site 205918013007 G-X-G motif; other site 205918013008 glutathione reductase; Validated; Region: PRK06116 205918013009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918013010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918013011 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205918013012 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 205918013013 active site 205918013014 tetramer interface; other site 205918013015 1 probable transmembrane helix predicted by TMHMM2.0 205918013016 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 205918013017 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 205918013018 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 205918013019 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 205918013020 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 205918013021 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205918013022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918013023 active site 205918013024 motif I; other site 205918013025 motif II; other site 205918013026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918013027 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 205918013028 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 205918013029 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 205918013030 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 205918013031 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 205918013032 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918013033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918013034 Coenzyme A binding pocket [chemical binding]; other site 205918013035 glycogen synthase; Provisional; Region: glgA; PRK00654 205918013036 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 205918013037 ADP-binding pocket [chemical binding]; other site 205918013038 homodimer interface [polypeptide binding]; other site 205918013039 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 205918013040 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 205918013041 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 205918013042 catalytic site [active] 205918013043 active site 205918013044 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 205918013045 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 205918013046 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 205918013047 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 205918013048 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 205918013049 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 205918013050 active site 205918013051 catalytic site [active] 205918013052 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 205918013053 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 205918013054 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 205918013055 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 205918013056 active site 205918013057 catalytic site [active] 205918013058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918013059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918013060 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 205918013061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918013062 S-adenosylmethionine binding site [chemical binding]; other site 205918013063 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 205918013064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918013065 active site 205918013066 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 205918013067 azoreductase; Reviewed; Region: PRK00170 205918013068 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918013069 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918013070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013071 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 205918013072 putative effector binding pocket; other site 205918013073 putative dimerization interface [polypeptide binding]; other site 205918013074 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918013075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 205918013076 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 205918013077 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013078 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013079 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013080 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 205918013081 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013082 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013083 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013084 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013085 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013086 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013087 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 205918013088 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013089 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013090 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013091 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013092 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 205918013093 AAA domain; Region: AAA_28; pfam13521 205918013094 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 205918013095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013096 Walker A motif; other site 205918013097 ATP binding site [chemical binding]; other site 205918013098 Walker B motif; other site 205918013099 arginine finger; other site 205918013100 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918013101 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918013102 metal ion-dependent adhesion site (MIDAS); other site 205918013103 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 205918013104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013105 Walker A motif; other site 205918013106 ATP binding site [chemical binding]; other site 205918013107 Walker B motif; other site 205918013108 arginine finger; other site 205918013109 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 205918013110 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 205918013111 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 205918013112 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 205918013113 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 205918013114 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 205918013115 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 205918013116 1 probable transmembrane helix predicted by TMHMM2.0 205918013117 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 205918013118 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013119 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013120 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013121 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013122 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013123 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013124 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 205918013125 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 205918013126 active site 205918013127 SAM binding site [chemical binding]; other site 205918013128 homodimer interface [polypeptide binding]; other site 205918013129 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 205918013130 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 205918013131 dimer interface [polypeptide binding]; other site 205918013132 PYR/PP interface [polypeptide binding]; other site 205918013133 TPP binding site [chemical binding]; other site 205918013134 substrate binding site [chemical binding]; other site 205918013135 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 205918013136 TPP-binding site; other site 205918013137 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 205918013138 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918013139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918013140 putative DNA binding site [nucleotide binding]; other site 205918013141 putative Zn2+ binding site [ion binding]; other site 205918013142 AsnC family; Region: AsnC_trans_reg; pfam01037 205918013143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918013144 DNA binding residues [nucleotide binding] 205918013145 1 probable transmembrane helix predicted by TMHMM2.0 205918013146 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 205918013147 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 205918013148 active site 205918013149 Zn binding site [ion binding]; other site 205918013150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918013152 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013153 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013154 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013155 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013156 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013157 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013158 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013159 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013160 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013161 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013162 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013163 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918013165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918013166 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 205918013167 Leucine-rich repeats; other site 205918013168 Leucine rich repeat; Region: LRR_8; pfam13855 205918013169 Leucine rich repeat; Region: LRR_8; pfam13855 205918013170 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 205918013171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918013172 active site 205918013173 ATP binding site [chemical binding]; other site 205918013174 substrate binding site [chemical binding]; other site 205918013175 activation loop (A-loop); other site 205918013176 hypothetical protein; Provisional; Region: PRK12378 205918013177 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 205918013178 enoyl-CoA hydratase; Provisional; Region: PRK05862 205918013179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918013180 substrate binding site [chemical binding]; other site 205918013181 oxyanion hole (OAH) forming residues; other site 205918013182 trimer interface [polypeptide binding]; other site 205918013183 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 205918013184 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 205918013185 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918013186 dimer interface [polypeptide binding]; other site 205918013187 active site 205918013188 Water Stress and Hypersensitive response; Region: WHy; smart00769 205918013189 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 205918013190 1 probable transmembrane helix predicted by TMHMM2.0 205918013191 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 205918013192 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 205918013193 PA14 domain; Region: PA14; pfam07691 205918013194 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 205918013195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918013196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918013197 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 205918013198 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205918013199 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013200 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013201 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013202 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013203 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013204 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013205 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013206 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013207 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013208 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013209 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013210 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013211 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 205918013212 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 205918013213 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 205918013214 active site 205918013215 Zn binding site [ion binding]; other site 205918013216 Paraquat-inducible protein A; Region: PqiA; pfam04403 205918013217 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013218 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013219 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013220 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013221 Paraquat-inducible protein A; Region: PqiA; pfam04403 205918013222 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013223 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013224 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013225 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013226 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 205918013227 mce related protein; Region: MCE; pfam02470 205918013228 mce related protein; Region: MCE; pfam02470 205918013229 mce related protein; Region: MCE; pfam02470 205918013230 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 205918013231 1 probable transmembrane helix predicted by TMHMM2.0 205918013232 Protein of unknown function (DUF330); Region: DUF330; pfam03886 205918013233 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918013234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013235 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918013236 putative effector binding pocket; other site 205918013237 dimerization interface [polypeptide binding]; other site 205918013238 Pirin; Region: Pirin; pfam02678 205918013239 Pirin-related protein [General function prediction only]; Region: COG1741 205918013240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918013241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918013242 active site 205918013243 catalytic tetrad [active] 205918013244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 205918013247 putative effector binding pocket; other site 205918013248 putative dimerization interface [polypeptide binding]; other site 205918013249 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 205918013250 Na binding site [ion binding]; other site 205918013251 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013252 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013253 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013254 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013255 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013256 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013257 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013258 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013259 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013260 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013261 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013262 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013263 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013264 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013265 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013266 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 205918013267 Phosphotransferase enzyme family; Region: APH; pfam01636 205918013268 active site 205918013269 ATP binding site [chemical binding]; other site 205918013270 substrate binding site [chemical binding]; other site 205918013271 dimer interface [polypeptide binding]; other site 205918013272 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 205918013273 active site 205918013274 ATP binding site [chemical binding]; other site 205918013275 dimer interface [polypeptide binding]; other site 205918013276 Phosphotransferase enzyme family; Region: APH; pfam01636 205918013277 substrate binding site [chemical binding]; other site 205918013278 allantoate amidohydrolase; Reviewed; Region: PRK09290 205918013279 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 205918013280 active site 205918013281 metal binding site [ion binding]; metal-binding site 205918013282 dimer interface [polypeptide binding]; other site 205918013283 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 205918013284 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 205918013285 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 205918013286 putative amidase; Provisional; Region: PRK06169 205918013287 Amidase; Region: Amidase; pfam01425 205918013288 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 205918013289 active site 205918013290 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918013291 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918013292 GAF domain; Region: GAF; pfam01590 205918013293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918013294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918013295 ATP binding site [chemical binding]; other site 205918013296 Mg2+ binding site [ion binding]; other site 205918013297 G-X-G motif; other site 205918013298 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 205918013299 C-terminal domain interface [polypeptide binding]; other site 205918013300 GSH binding site (G-site) [chemical binding]; other site 205918013301 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918013302 dimer interface [polypeptide binding]; other site 205918013303 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 205918013304 dimer interface [polypeptide binding]; other site 205918013305 N-terminal domain interface [polypeptide binding]; other site 205918013306 substrate binding pocket (H-site) [chemical binding]; other site 205918013307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013309 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 205918013310 putative effector binding pocket; other site 205918013311 putative dimerization interface [polypeptide binding]; other site 205918013312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013313 putative substrate translocation pore; other site 205918013314 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013315 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013316 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013317 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013318 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013319 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013320 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013321 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013322 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013323 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013324 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013325 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013326 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013327 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013328 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 205918013329 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918013330 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918013331 active site 205918013332 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 205918013333 dimer interface [polypeptide binding]; other site 205918013334 non-prolyl cis peptide bond; other site 205918013335 insertion regions; other site 205918013336 Nitronate monooxygenase; Region: NMO; pfam03060 205918013337 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 205918013338 FMN binding site [chemical binding]; other site 205918013339 substrate binding site [chemical binding]; other site 205918013340 putative catalytic residue [active] 205918013341 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 205918013342 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 205918013343 tartrate dehydrogenase; Region: TTC; TIGR02089 205918013344 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 205918013345 active site 205918013346 catalytic residues [active] 205918013347 metal binding site [ion binding]; metal-binding site 205918013348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013350 LysR substrate binding domain; Region: LysR_substrate; pfam03466 205918013351 dimerization interface [polypeptide binding]; other site 205918013352 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918013353 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918013354 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 205918013355 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918013356 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918013357 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205918013358 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918013359 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918013360 1 probable transmembrane helix predicted by TMHMM2.0 205918013361 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 205918013362 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 205918013363 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918013364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918013365 Walker A/P-loop; other site 205918013366 ATP binding site [chemical binding]; other site 205918013367 Q-loop/lid; other site 205918013368 ABC transporter signature motif; other site 205918013369 Walker B; other site 205918013370 D-loop; other site 205918013371 H-loop/switch region; other site 205918013372 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013373 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013374 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013375 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013376 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918013377 1 probable transmembrane helix predicted by TMHMM2.0 205918013378 glutamate carboxypeptidase; Reviewed; Region: PRK06133 205918013379 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 205918013380 metal binding site [ion binding]; metal-binding site 205918013381 dimer interface [polypeptide binding]; other site 205918013382 acriflavin resistance protein 205918013383 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013384 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013385 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013386 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013387 acriflavin resistance protein 205918013388 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918013389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918013390 E3 interaction surface; other site 205918013391 lipoyl attachment site [posttranslational modification]; other site 205918013392 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918013393 MltA-interacting protein MipA; Region: MipA; cl01504 205918013394 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 205918013395 1 probable transmembrane helix predicted by TMHMM2.0 205918013396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918013397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013398 active site 205918013399 phosphorylation site [posttranslational modification] 205918013400 intermolecular recognition site; other site 205918013401 dimerization interface [polypeptide binding]; other site 205918013402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918013403 DNA binding site [nucleotide binding] 205918013404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918013405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918013406 dimerization interface [polypeptide binding]; other site 205918013407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918013408 dimer interface [polypeptide binding]; other site 205918013409 phosphorylation site [posttranslational modification] 205918013410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918013411 ATP binding site [chemical binding]; other site 205918013412 Mg2+ binding site [ion binding]; other site 205918013413 G-X-G motif; other site 205918013414 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013415 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013416 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 205918013417 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 205918013418 Sulfate transporter family; Region: Sulfate_transp; pfam00916 205918013419 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 205918013420 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013421 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013422 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013423 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013424 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013425 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013426 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013427 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013428 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013429 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013430 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013431 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918013432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918013433 DNA-binding site [nucleotide binding]; DNA binding site 205918013434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918013435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918013436 homodimer interface [polypeptide binding]; other site 205918013437 catalytic residue [active] 205918013438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918013439 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 205918013440 putative ADP-binding pocket [chemical binding]; other site 205918013441 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 205918013442 Pleckstrin homology-like domain; Region: PH-like; cl17171 205918013443 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918013444 1 probable transmembrane helix predicted by TMHMM2.0 205918013445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918013446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013447 active site 205918013448 phosphorylation site [posttranslational modification] 205918013449 intermolecular recognition site; other site 205918013450 dimerization interface [polypeptide binding]; other site 205918013451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918013452 DNA binding site [nucleotide binding] 205918013453 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 205918013454 active site 205918013455 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013456 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013457 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013458 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013459 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013460 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013461 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 205918013462 catalytic core [active] 205918013463 1 probable transmembrane helix predicted by TMHMM2.0 205918013464 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 205918013465 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 205918013466 putative ligand binding residues [chemical binding]; other site 205918013467 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 205918013468 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918013469 ABC-ATPase subunit interface; other site 205918013470 dimer interface [polypeptide binding]; other site 205918013471 putative PBP binding regions; other site 205918013472 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013473 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013474 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013475 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013476 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013477 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013478 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013479 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013480 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918013481 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205918013482 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918013483 Walker A/P-loop; other site 205918013484 ATP binding site [chemical binding]; other site 205918013485 Q-loop/lid; other site 205918013486 ABC transporter signature motif; other site 205918013487 Walker B; other site 205918013488 D-loop; other site 205918013489 H-loop/switch region; other site 205918013490 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 205918013491 Peptidase family U32; Region: Peptidase_U32; pfam01136 205918013492 Collagenase; Region: DUF3656; pfam12392 205918013493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918013494 Coenzyme A binding pocket [chemical binding]; other site 205918013495 nitrite reductase subunit NirD; Provisional; Region: PRK14989 205918013496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918013497 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 205918013498 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918013499 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 205918013500 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 205918013501 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918013502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013504 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 205918013505 putative substrate binding pocket [chemical binding]; other site 205918013506 putative dimerization interface [polypeptide binding]; other site 205918013507 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 205918013508 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 205918013509 Walker A/P-loop; other site 205918013510 ATP binding site [chemical binding]; other site 205918013511 Q-loop/lid; other site 205918013512 ABC transporter signature motif; other site 205918013513 Walker B; other site 205918013514 D-loop; other site 205918013515 H-loop/switch region; other site 205918013516 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 205918013517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918013518 dimer interface [polypeptide binding]; other site 205918013519 conserved gate region; other site 205918013520 putative PBP binding loops; other site 205918013521 ABC-ATPase subunit interface; other site 205918013522 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013523 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013524 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013525 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013526 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013527 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918013529 dimer interface [polypeptide binding]; other site 205918013530 conserved gate region; other site 205918013531 putative PBP binding loops; other site 205918013532 ABC-ATPase subunit interface; other site 205918013533 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013534 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013535 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013536 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013537 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013538 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 205918013539 MarB protein; Region: MarB; cl08087 205918013540 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 205918013541 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 205918013542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013544 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 205918013545 putative dimerization interface [polypeptide binding]; other site 205918013546 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918013547 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 205918013548 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918013549 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013550 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013551 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013552 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013553 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013554 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013555 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013556 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013557 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013558 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013559 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 205918013560 putative active cleft [active] 205918013561 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918013562 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918013563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918013564 dimerization interface [polypeptide binding]; other site 205918013565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918013566 dimer interface [polypeptide binding]; other site 205918013567 putative CheW interface [polypeptide binding]; other site 205918013568 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013569 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013570 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 205918013571 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 205918013572 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 205918013573 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 205918013574 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 205918013575 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918013576 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918013577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918013578 DNA-binding site [nucleotide binding]; DNA binding site 205918013579 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 205918013580 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 205918013581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013582 putative substrate translocation pore; other site 205918013583 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013584 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013585 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013586 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013587 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013588 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013589 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013590 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013591 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013592 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013593 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013594 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013595 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 205918013596 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 205918013597 active site 205918013598 tetramer interface [polypeptide binding]; other site 205918013599 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 205918013600 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013601 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013602 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013603 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013604 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013605 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 205918013606 dimerization interface [polypeptide binding]; other site 205918013607 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 205918013608 NAD binding site [chemical binding]; other site 205918013609 ligand binding site [chemical binding]; other site 205918013610 catalytic site [active] 205918013611 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918013612 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918013613 N-terminal plug; other site 205918013614 ligand-binding site [chemical binding]; other site 205918013615 Isochorismatase family; Region: Isochorismatase; pfam00857 205918013616 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 205918013617 catalytic triad [active] 205918013618 metal binding site [ion binding]; metal-binding site 205918013619 conserved cis-peptide bond; other site 205918013620 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 205918013621 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013622 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013623 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013624 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013625 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013626 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918013628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013629 active site 205918013630 phosphorylation site [posttranslational modification] 205918013631 intermolecular recognition site; other site 205918013632 dimerization interface [polypeptide binding]; other site 205918013633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918013634 DNA binding site [nucleotide binding] 205918013635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918013636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918013637 dimerization interface [polypeptide binding]; other site 205918013638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918013639 dimer interface [polypeptide binding]; other site 205918013640 phosphorylation site [posttranslational modification] 205918013641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918013642 ATP binding site [chemical binding]; other site 205918013643 Mg2+ binding site [ion binding]; other site 205918013644 G-X-G motif; other site 205918013645 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013646 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918013648 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918013649 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918013650 putative membrane fusion protein; Region: TIGR02828 205918013651 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918013652 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918013653 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918013654 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918013655 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013656 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013657 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013658 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013659 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013660 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013661 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013662 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013663 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013664 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013665 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013666 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 205918013667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918013668 active site 205918013669 benzoate transport; Region: 2A0115; TIGR00895 205918013670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013671 putative substrate translocation pore; other site 205918013672 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013673 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013674 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013675 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013676 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013677 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013678 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013679 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013680 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013681 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013682 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013683 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013684 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205918013685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918013686 DNA-binding site [nucleotide binding]; DNA binding site 205918013687 UTRA domain; Region: UTRA; pfam07702 205918013688 TIGR02646 family protein; Region: TIGR02646 205918013689 AAA domain; Region: AAA_23; pfam13476 205918013690 AAA domain; Region: AAA_21; pfam13304 205918013691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 205918013692 Q-loop/lid; other site 205918013693 ABC transporter signature motif; other site 205918013694 Walker B; other site 205918013695 D-loop; other site 205918013696 H-loop/switch region; other site 205918013697 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205918013698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013699 putative substrate translocation pore; other site 205918013700 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013701 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013702 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013703 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013704 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013705 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013706 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013707 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013708 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013709 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013710 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013711 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013712 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013713 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013714 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013715 Predicted esterase [General function prediction only]; Region: COG0400 205918013716 putative hydrolase; Provisional; Region: PRK11460 205918013717 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013718 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013719 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013720 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 205918013721 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918013722 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 205918013723 1 probable transmembrane helix predicted by TMHMM2.0 205918013724 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 205918013725 1 probable transmembrane helix predicted by TMHMM2.0 205918013726 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 205918013727 1 probable transmembrane helix predicted by TMHMM2.0 205918013728 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 205918013729 1 probable transmembrane helix predicted by TMHMM2.0 205918013730 general secretion pathway protein J; Validated; Region: PRK08808 205918013731 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 205918013732 1 probable transmembrane helix predicted by TMHMM2.0 205918013733 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 205918013734 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918013735 1 probable transmembrane helix predicted by TMHMM2.0 205918013736 1 probable transmembrane helix predicted by TMHMM2.0 205918013737 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 205918013738 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 205918013739 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 205918013740 1 probable transmembrane helix predicted by TMHMM2.0 205918013741 type II secretion system protein F; Region: GspF; TIGR02120 205918013742 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918013743 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918013744 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013745 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013746 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013747 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918013748 type II secretion system protein E; Region: type_II_gspE; TIGR02533 205918013749 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 205918013750 Walker A motif; other site 205918013751 ATP binding site [chemical binding]; other site 205918013752 Walker B motif; other site 205918013753 1 probable transmembrane helix predicted by TMHMM2.0 205918013754 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 205918013755 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 205918013756 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 205918013757 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 205918013758 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 205918013759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918013760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918013761 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 205918013762 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918013763 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918013764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918013767 dimerization interface [polypeptide binding]; other site 205918013768 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 205918013769 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 205918013770 dimer interface [polypeptide binding]; other site 205918013771 NADP binding site [chemical binding]; other site 205918013772 catalytic residues [active] 205918013773 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 205918013774 hydroxyglutarate oxidase; Provisional; Region: PRK11728 205918013775 1 probable transmembrane helix predicted by TMHMM2.0 205918013776 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918013777 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205918013778 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918013779 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918013780 1 probable transmembrane helix predicted by TMHMM2.0 205918013781 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 205918013782 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 205918013783 Walker A/P-loop; other site 205918013784 ATP binding site [chemical binding]; other site 205918013785 Q-loop/lid; other site 205918013786 ABC transporter signature motif; other site 205918013787 Walker B; other site 205918013788 D-loop; other site 205918013789 H-loop/switch region; other site 205918013790 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013791 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013792 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013793 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013794 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013795 Protease inhibitor Inh; Region: Inh; pfam02974 205918013796 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 205918013797 active site 205918013798 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918013799 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 205918013800 YccA-like proteins; Region: YccA_like; cd10433 205918013801 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013802 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013803 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013804 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013805 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013806 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013807 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013810 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 205918013811 putative dimerization interface [polypeptide binding]; other site 205918013812 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918013813 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205918013814 citrate-proton symporter; Provisional; Region: PRK15075 205918013815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013816 putative substrate translocation pore; other site 205918013817 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013818 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013819 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013820 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013821 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013822 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013823 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013824 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013825 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013826 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013827 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013828 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013829 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 205918013830 sulfur relay protein TusC; Validated; Region: PRK00211 205918013831 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 205918013832 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 205918013833 DsrC like protein; Region: DsrC; pfam04358 205918013834 hypothetical protein; Validated; Region: PRK09071 205918013835 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 205918013836 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 205918013837 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 205918013838 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 205918013839 putative dimer interface [polypeptide binding]; other site 205918013840 N-terminal domain interface [polypeptide binding]; other site 205918013841 putative substrate binding pocket (H-site) [chemical binding]; other site 205918013842 siroheme synthase; Provisional; Region: cysG; PRK10637 205918013843 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 205918013844 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 205918013845 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 205918013846 active site 205918013847 SAM binding site [chemical binding]; other site 205918013848 homodimer interface [polypeptide binding]; other site 205918013849 seryl-tRNA synthetase; Provisional; Region: PRK05431 205918013850 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 205918013851 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 205918013852 dimer interface [polypeptide binding]; other site 205918013853 active site 205918013854 motif 1; other site 205918013855 motif 2; other site 205918013856 motif 3; other site 205918013857 camphor resistance protein CrcB; Provisional; Region: PRK14234 205918013858 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013859 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013860 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013861 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013862 recombination factor protein RarA; Reviewed; Region: PRK13342 205918013863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013864 Walker A motif; other site 205918013865 ATP binding site [chemical binding]; other site 205918013866 Walker B motif; other site 205918013867 arginine finger; other site 205918013868 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 205918013869 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 205918013870 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 205918013871 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 205918013872 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 205918013873 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 205918013874 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013875 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013876 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013877 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013878 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 205918013879 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 205918013880 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 205918013881 Protein of unknown function (DUF402); Region: DUF402; cl00979 205918013882 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 205918013883 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 205918013884 rRNA binding site [nucleotide binding]; other site 205918013885 predicted 30S ribosome binding site; other site 205918013886 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 205918013887 Clp amino terminal domain; Region: Clp_N; pfam02861 205918013888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013889 Walker A motif; other site 205918013890 ATP binding site [chemical binding]; other site 205918013891 Walker B motif; other site 205918013892 arginine finger; other site 205918013893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013894 Walker A motif; other site 205918013895 ATP binding site [chemical binding]; other site 205918013896 Walker B motif; other site 205918013897 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 205918013898 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 205918013899 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205918013900 DNA-binding site [nucleotide binding]; DNA binding site 205918013901 RNA-binding motif; other site 205918013902 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 205918013903 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 205918013904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918013905 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918013907 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 205918013908 putative effector binding pocket; other site 205918013909 putative dimerization interface [polypeptide binding]; other site 205918013910 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 205918013911 nudix motif; other site 205918013912 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 205918013913 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 205918013914 putative lysogenization regulator; Reviewed; Region: PRK00218 205918013915 adenylosuccinate lyase; Provisional; Region: PRK09285 205918013916 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 205918013917 tetramer interface [polypeptide binding]; other site 205918013918 active site 205918013919 Uncharacterized conserved protein [Function unknown]; Region: COG2850 205918013920 Cupin domain; Region: Cupin_2; cl17218 205918013921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918013922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918013923 Coenzyme A binding pocket [chemical binding]; other site 205918013924 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013925 1 probable transmembrane helix predicted by TMHMM2.0 205918013926 isocitrate lyase; Provisional; Region: PRK15063 205918013927 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918013928 tetramer interface [polypeptide binding]; other site 205918013929 active site 205918013930 Mg2+/Mn2+ binding site [ion binding]; other site 205918013931 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 205918013932 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013933 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013934 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013935 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 205918013936 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 205918013937 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 205918013938 NADH dehydrogenase subunit D; Validated; Region: PRK06075 205918013939 NADH dehydrogenase subunit E; Validated; Region: PRK07539 205918013940 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 205918013941 putative dimer interface [polypeptide binding]; other site 205918013942 [2Fe-2S] cluster binding site [ion binding]; other site 205918013943 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 205918013944 SLBB domain; Region: SLBB; pfam10531 205918013945 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 205918013946 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918013947 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 205918013948 catalytic loop [active] 205918013949 iron binding site [ion binding]; other site 205918013950 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 205918013951 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 205918013952 [4Fe-4S] binding site [ion binding]; other site 205918013953 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 205918013954 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 205918013955 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013956 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013957 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013958 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013959 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013960 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013961 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013962 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013963 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 205918013964 4Fe-4S binding domain; Region: Fer4; pfam00037 205918013965 4Fe-4S binding domain; Region: Fer4; pfam00037 205918013966 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 205918013967 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 205918013968 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013969 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013970 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013971 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013972 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013973 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 205918013974 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013975 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013976 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013977 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 205918013978 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 205918013979 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 205918013980 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205918013981 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013982 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013983 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013984 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013985 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013986 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013987 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013988 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013989 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013990 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013991 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013992 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013993 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013994 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013995 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013996 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013997 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 205918013998 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205918013999 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014000 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014001 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014002 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014003 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014004 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014005 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014006 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014007 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014008 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014009 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014010 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014011 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014012 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014013 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 205918014014 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205918014015 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014016 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014017 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014018 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014019 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014020 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014021 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014022 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014023 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014024 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014025 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014026 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014027 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014028 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918014029 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205918014030 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918014031 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014032 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014033 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014034 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014035 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014036 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014037 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014038 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918014039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014040 ATP binding site [chemical binding]; other site 205918014041 Mg2+ binding site [ion binding]; other site 205918014042 G-X-G motif; other site 205918014043 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014044 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014045 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 205918014046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014047 active site 205918014048 phosphorylation site [posttranslational modification] 205918014049 intermolecular recognition site; other site 205918014050 dimerization interface [polypeptide binding]; other site 205918014051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918014052 DNA binding site [nucleotide binding] 205918014053 Predicted membrane protein [Function unknown]; Region: COG3212 205918014054 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 205918014055 Predicted membrane protein [Function unknown]; Region: COG3212 205918014056 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 205918014057 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 205918014058 active site 205918014059 threonine and homoserine efflux system; Provisional; Region: PRK10532 205918014060 EamA-like transporter family; Region: EamA; pfam00892 205918014061 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014062 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014063 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014064 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014065 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014066 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014067 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014068 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014069 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014070 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014071 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 205918014072 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 205918014073 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 205918014074 active site 205918014075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918014076 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 205918014077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918014078 catalytic residue [active] 205918014079 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 205918014080 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 205918014081 inhibitor-cofactor binding pocket; inhibition site 205918014082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918014083 catalytic residue [active] 205918014084 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 205918014085 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 205918014086 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014087 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014088 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014089 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014090 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014091 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014092 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014093 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014094 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014095 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014096 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014097 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014098 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014099 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205918014100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918014101 active site 205918014102 Low molecular weight phosphatase family; Region: LMWPc; cd00115 205918014103 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 205918014104 active site 205918014105 tyrosine kinase; Provisional; Region: PRK11519 205918014106 Chain length determinant protein; Region: Wzz; pfam02706 205918014107 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 205918014108 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 205918014109 Nucleotide binding site [chemical binding]; other site 205918014110 P loop; other site 205918014111 DTAP/Switch II; other site 205918014112 Switch I; other site 205918014113 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014114 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014115 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 205918014116 transcriptional activator RfaH; Region: RfaH; TIGR01955 205918014117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918014118 active site 205918014119 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 205918014120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918014121 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 205918014122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918014123 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918014124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918014125 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 205918014126 putative ADP-binding pocket [chemical binding]; other site 205918014127 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 205918014128 Bacterial sugar transferase; Region: Bac_transf; pfam02397 205918014129 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014130 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014131 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014132 polysaccharide export protein Wza; Provisional; Region: PRK15078 205918014133 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 205918014134 SLBB domain; Region: SLBB; pfam10531 205918014135 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 205918014136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918014137 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918014138 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014139 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014140 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014141 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014142 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014143 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014144 1 probable transmembrane helix predicted by TMHMM2.0 205918014145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918014146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918014147 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 205918014148 putative dimerization interface [polypeptide binding]; other site 205918014149 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 205918014150 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 205918014151 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 205918014152 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014153 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014154 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014155 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014156 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014157 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014158 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014159 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014160 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014161 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014162 hypothetical protein; Validated; Region: PRK06186 205918014163 conserved cys residue [active] 205918014164 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 205918014165 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 205918014166 putative ligand binding site [chemical binding]; other site 205918014167 NAD binding site [chemical binding]; other site 205918014168 catalytic site [active] 205918014169 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 205918014170 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 205918014171 active site 205918014172 catalytic site [active] 205918014173 metal binding site [ion binding]; metal-binding site 205918014174 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918014175 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918014176 N-terminal plug; other site 205918014177 ligand-binding site [chemical binding]; other site 205918014178 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 205918014179 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 205918014180 domain interface [polypeptide binding]; other site 205918014181 putative active site [active] 205918014182 catalytic site [active] 205918014183 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 205918014184 domain interface [polypeptide binding]; other site 205918014185 putative active site [active] 205918014186 catalytic site [active] 205918014187 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 205918014188 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 205918014189 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 205918014190 active site 205918014191 DNA binding site [nucleotide binding] 205918014192 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 205918014193 DNA binding site [nucleotide binding] 205918014194 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 205918014195 nucleotide binding site [chemical binding]; other site 205918014196 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 205918014197 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 205918014198 putative DNA binding site [nucleotide binding]; other site 205918014199 putative homodimer interface [polypeptide binding]; other site 205918014200 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 205918014201 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918014202 active site 205918014203 dimer interface [polypeptide binding]; other site 205918014204 non-prolyl cis peptide bond; other site 205918014205 insertion regions; other site 205918014206 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 205918014207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918014208 Walker A motif; other site 205918014209 ATP binding site [chemical binding]; other site 205918014210 Walker B motif; other site 205918014211 arginine finger; other site 205918014212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 205918014213 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 205918014214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918014215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918014216 non-specific DNA binding site [nucleotide binding]; other site 205918014217 salt bridge; other site 205918014218 sequence-specific DNA binding site [nucleotide binding]; other site 205918014219 Cupin domain; Region: Cupin_2; pfam07883 205918014220 EamA-like transporter family; Region: EamA; pfam00892 205918014221 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918014222 EamA-like transporter family; Region: EamA; pfam00892 205918014223 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014224 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014225 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014226 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014227 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014228 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014229 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014230 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014231 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 205918014232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205918014233 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 205918014234 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 205918014235 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014236 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014237 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014238 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014239 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014240 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014241 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014242 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014243 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014244 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014245 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014246 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014247 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014248 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014249 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014250 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014251 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014252 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014253 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014254 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014255 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014256 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014257 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918014258 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 205918014259 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014260 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014261 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014262 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 205918014263 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 205918014264 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014265 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014266 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014267 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014268 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014269 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014270 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014271 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014272 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014273 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014274 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014275 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014276 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014277 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014278 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014279 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 205918014280 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014281 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014282 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 205918014283 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014284 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014285 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014286 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 205918014287 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014288 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014289 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918014290 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 205918014291 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 205918014292 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918014293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014294 dimer interface [polypeptide binding]; other site 205918014295 putative CheW interface [polypeptide binding]; other site 205918014296 1 probable transmembrane helix predicted by TMHMM2.0 205918014297 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 205918014298 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205918014299 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918014300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918014301 TM-ABC transporter signature motif; other site 205918014302 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014303 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014304 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014305 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014306 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014307 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014308 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014309 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014310 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918014311 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205918014312 Walker A/P-loop; other site 205918014313 ATP binding site [chemical binding]; other site 205918014314 Q-loop/lid; other site 205918014315 ABC transporter signature motif; other site 205918014316 Walker B; other site 205918014317 D-loop; other site 205918014318 H-loop/switch region; other site 205918014319 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205918014320 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 205918014321 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918014322 putative ligand binding site [chemical binding]; other site 205918014323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205918014324 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 205918014325 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 205918014326 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 205918014327 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205918014328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 205918014329 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 205918014330 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 205918014331 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205918014332 PYR/PP interface [polypeptide binding]; other site 205918014333 dimer interface [polypeptide binding]; other site 205918014334 TPP binding site [chemical binding]; other site 205918014335 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 205918014336 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 205918014337 TPP-binding site; other site 205918014338 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 205918014339 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 205918014340 Metal-binding active site; metal-binding site 205918014341 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 205918014342 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 205918014343 tetrameric interface [polypeptide binding]; other site 205918014344 NAD binding site [chemical binding]; other site 205918014345 catalytic residues [active] 205918014346 KduI/IolB family; Region: KduI; pfam04962 205918014347 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 205918014348 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918014349 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 205918014350 substrate binding site [chemical binding]; other site 205918014351 ATP binding site [chemical binding]; other site 205918014352 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 205918014353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 205918014354 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 205918014355 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918014356 putative active site [active] 205918014357 Predicted integral membrane protein [Function unknown]; Region: COG0392 205918014358 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014359 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014360 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014361 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014362 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014363 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014364 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014365 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014366 cardiolipin synthase 2; Provisional; Region: PRK11263 205918014367 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 205918014368 putative active site [active] 205918014369 catalytic site [active] 205918014370 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 205918014371 putative active site [active] 205918014372 catalytic site [active] 205918014373 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 205918014374 putative catalytic site [active] 205918014375 putative metal binding site [ion binding]; other site 205918014376 putative phosphate binding site [ion binding]; other site 205918014377 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 205918014378 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014379 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014380 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014381 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014382 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 205918014383 beta-hexosaminidase; Provisional; Region: PRK05337 205918014384 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 205918014385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918014386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918014387 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 205918014388 LexA repressor; Validated; Region: PRK00215 205918014389 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 205918014390 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918014391 Catalytic site [active] 205918014392 Cell division inhibitor SulA; Region: SulA; cl01880 205918014393 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 205918014394 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 205918014395 active site 205918014396 interdomain interaction site; other site 205918014397 putative metal-binding site [ion binding]; other site 205918014398 nucleotide binding site [chemical binding]; other site 205918014399 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205918014400 domain I; other site 205918014401 DNA binding groove [nucleotide binding] 205918014402 phosphate binding site [ion binding]; other site 205918014403 domain II; other site 205918014404 domain III; other site 205918014405 nucleotide binding site [chemical binding]; other site 205918014406 catalytic site [active] 205918014407 domain IV; other site 205918014408 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205918014409 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205918014410 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 205918014411 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 205918014412 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 205918014413 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 205918014414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918014415 dimer interface [polypeptide binding]; other site 205918014416 active site 205918014417 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 205918014418 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918014419 substrate binding site [chemical binding]; other site 205918014420 oxyanion hole (OAH) forming residues; other site 205918014421 trimer interface [polypeptide binding]; other site 205918014422 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 205918014423 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205918014424 1 probable transmembrane helix predicted by TMHMM2.0 205918014425 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205918014426 Ligand Binding Site [chemical binding]; other site 205918014427 ABC transporter ATPase component; Reviewed; Region: PRK11147 205918014428 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918014429 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918014430 ABC transporter; Region: ABC_tran_2; pfam12848 205918014431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918014432 lytic murein transglycosylase; Provisional; Region: PRK11619 205918014433 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918014434 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918014435 catalytic residue [active] 205918014436 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 205918014437 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 205918014438 MOSC domain; Region: MOSC; pfam03473 205918014439 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 205918014440 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918014441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014442 active site 205918014443 phosphorylation site [posttranslational modification] 205918014444 intermolecular recognition site; other site 205918014445 dimerization interface [polypeptide binding]; other site 205918014446 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918014447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014448 active site 205918014449 phosphorylation site [posttranslational modification] 205918014450 intermolecular recognition site; other site 205918014451 dimerization interface [polypeptide binding]; other site 205918014452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918014453 DNA binding residues [nucleotide binding] 205918014454 lipid kinase; Reviewed; Region: PRK13054 205918014455 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 205918014456 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 205918014457 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 205918014458 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014459 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014460 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014461 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014462 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014463 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 205918014464 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 205918014465 Substrate binding site; other site 205918014466 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 205918014467 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 205918014468 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 205918014469 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 205918014470 Chain length determinant protein; Region: Wzz; cl15801 205918014471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 205918014472 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014473 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014474 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918014475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918014476 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 205918014477 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 205918014478 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 205918014479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918014480 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918014481 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 205918014482 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014483 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014484 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014485 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014486 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014487 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014488 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014489 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014490 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014491 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014492 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014493 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014494 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014495 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 205918014496 trimer interface [polypeptide binding]; other site 205918014497 active site 205918014498 substrate binding site [chemical binding]; other site 205918014499 CoA binding site [chemical binding]; other site 205918014500 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 205918014501 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 205918014502 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014503 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014504 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014505 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014506 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014507 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014508 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014509 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014510 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014511 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014512 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014513 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014514 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 205918014515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918014516 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 205918014517 putative dimerization interface [polypeptide binding]; other site 205918014518 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 205918014519 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 205918014520 gating phenylalanine in ion channel; other site 205918014521 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014522 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014523 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014524 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014525 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014526 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014527 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014528 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014529 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014530 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918014532 Transposase; Region: HTH_Tnp_1; cl17663 205918014533 putative transposase OrfB; Reviewed; Region: PHA02517 205918014534 HTH-like domain; Region: HTH_21; pfam13276 205918014535 Integrase core domain; Region: rve; pfam00665 205918014536 Integrase core domain; Region: rve_2; pfam13333 205918014537 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 205918014538 active site 205918014539 catalytic residues [active] 205918014540 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 205918014541 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 205918014542 potential catalytic triad [active] 205918014543 conserved cys residue [active] 205918014544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918014545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918014546 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 205918014547 substrate binding pocket [chemical binding]; other site 205918014548 dimerization interface [polypeptide binding]; other site 205918014549 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 205918014550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918014551 putative substrate translocation pore; other site 205918014552 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014553 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014554 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014555 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014556 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014557 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014558 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014559 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014560 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014561 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014562 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014563 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014564 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 205918014565 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 205918014566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918014567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918014568 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 205918014569 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 205918014570 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 205918014571 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 205918014572 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 205918014573 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 205918014574 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918014575 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918014576 Cache domain; Region: Cache_1; pfam02743 205918014577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918014578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918014579 metal binding site [ion binding]; metal-binding site 205918014580 active site 205918014581 I-site; other site 205918014582 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014583 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014584 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014585 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014586 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918014587 GAF domain; Region: GAF; pfam01590 205918014588 PAS domain S-box; Region: sensory_box; TIGR00229 205918014589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918014590 putative active site [active] 205918014591 heme pocket [chemical binding]; other site 205918014592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918014593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918014594 metal binding site [ion binding]; metal-binding site 205918014595 active site 205918014596 I-site; other site 205918014597 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918014598 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 205918014599 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 205918014600 dimer interface [polypeptide binding]; other site 205918014601 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 205918014602 active site 205918014603 Fe binding site [ion binding]; other site 205918014604 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 205918014605 FAD binding domain; Region: FAD_binding_4; pfam01565 205918014606 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 205918014607 FAD binding domain; Region: FAD_binding_4; pfam01565 205918014608 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 205918014609 Cysteine-rich domain; Region: CCG; pfam02754 205918014610 Cysteine-rich domain; Region: CCG; pfam02754 205918014611 Domain of unknown function (DUF336); Region: DUF336; cl01249 205918014612 Uncharacterized conserved protein [Function unknown]; Region: COG3391 205918014613 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 205918014614 structural tetrad; other site 205918014615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918014616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918014617 DNA binding site [nucleotide binding] 205918014618 domain linker motif; other site 205918014619 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 205918014620 putative dimerization interface [polypeptide binding]; other site 205918014621 putative ligand binding site [chemical binding]; other site 205918014622 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205918014623 AAA domain; Region: AAA_33; pfam13671 205918014624 ATP-binding site [chemical binding]; other site 205918014625 Gluconate-6-phosphate binding site [chemical binding]; other site 205918014626 fructuronate transporter; Provisional; Region: PRK10034; cl15264 205918014627 GntP family permease; Region: GntP_permease; pfam02447 205918014628 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014629 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014630 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014631 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014632 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014633 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014634 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014635 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014636 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014637 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014638 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014639 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014640 carbon storage regulator; Provisional; Region: PRK01712 205918014641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 205918014642 1 probable transmembrane helix predicted by TMHMM2.0 205918014643 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 205918014644 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205918014645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918014646 Coenzyme A binding pocket [chemical binding]; other site 205918014647 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918014648 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205918014649 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918014650 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918014651 N-terminal plug; other site 205918014652 ligand-binding site [chemical binding]; other site 205918014653 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 205918014654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918014655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918014656 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 205918014657 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918014658 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918014659 HAMP domain; Region: HAMP; pfam00672 205918014660 dimerization interface [polypeptide binding]; other site 205918014661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014662 dimer interface [polypeptide binding]; other site 205918014663 putative CheW interface [polypeptide binding]; other site 205918014664 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014665 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014666 SnoaL-like domain; Region: SnoaL_3; pfam13474 205918014667 SnoaL-like domain; Region: SnoaL_2; pfam12680 205918014668 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 205918014669 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 205918014670 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 205918014671 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918014672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918014673 dimerization interface [polypeptide binding]; other site 205918014674 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918014675 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014676 dimer interface [polypeptide binding]; other site 205918014677 putative CheW interface [polypeptide binding]; other site 205918014678 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014679 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014680 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918014681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918014682 Coenzyme A binding pocket [chemical binding]; other site 205918014683 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 205918014684 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 205918014685 tetramer interface [polypeptide binding]; other site 205918014686 heme binding pocket [chemical binding]; other site 205918014687 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205918014688 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205918014689 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205918014690 PAS fold; Region: PAS_4; pfam08448 205918014691 PAS fold; Region: PAS_4; pfam08448 205918014692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918014693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014694 dimer interface [polypeptide binding]; other site 205918014695 phosphorylation site [posttranslational modification] 205918014696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014697 ATP binding site [chemical binding]; other site 205918014698 Mg2+ binding site [ion binding]; other site 205918014699 G-X-G motif; other site 205918014700 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918014701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014702 active site 205918014703 phosphorylation site [posttranslational modification] 205918014704 intermolecular recognition site; other site 205918014705 dimerization interface [polypeptide binding]; other site 205918014706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918014707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918014708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918014709 dimerization interface [polypeptide binding]; other site 205918014710 Predicted membrane protein [Function unknown]; Region: COG4125 205918014711 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 205918014712 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 205918014713 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014714 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014715 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014716 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014717 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918014718 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014719 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014720 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014721 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014722 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014723 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014725 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014726 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014727 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014728 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014729 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014730 Predicted permeases [General function prediction only]; Region: RarD; COG2962 205918014731 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014732 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014733 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014734 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014735 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014736 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014737 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014738 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014739 Predicted ATPase [General function prediction only]; Region: COG1485 205918014740 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 205918014741 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 205918014742 Sulfate transporter family; Region: Sulfate_transp; pfam00916 205918014743 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 205918014744 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014748 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014749 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014750 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014751 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014752 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014753 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014754 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014755 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014756 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 205918014757 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918014758 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 205918014759 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 205918014760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918014761 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 205918014762 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 205918014763 DNA binding site [nucleotide binding] 205918014764 active site 205918014765 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205918014766 endonuclease III; Region: ENDO3c; smart00478 205918014767 minor groove reading motif; other site 205918014768 helix-hairpin-helix signature motif; other site 205918014769 substrate binding pocket [chemical binding]; other site 205918014770 active site 205918014771 Iron permease FTR1 family; Region: FTR1; cl00475 205918014772 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014773 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014774 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014775 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014776 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014777 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014778 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014779 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 205918014780 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 205918014781 Imelysin; Region: Peptidase_M75; pfam09375 205918014782 1 probable transmembrane helix predicted by TMHMM2.0 205918014783 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 205918014784 Imelysin; Region: Peptidase_M75; pfam09375 205918014785 1 probable transmembrane helix predicted by TMHMM2.0 205918014786 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 205918014787 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 205918014788 Moco binding site; other site 205918014789 metal coordination site [ion binding]; other site 205918014790 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 205918014791 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 205918014792 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014793 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014794 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014795 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014796 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918014797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014798 active site 205918014799 phosphorylation site [posttranslational modification] 205918014800 intermolecular recognition site; other site 205918014801 dimerization interface [polypeptide binding]; other site 205918014802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918014803 DNA binding site [nucleotide binding] 205918014804 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918014805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014806 dimer interface [polypeptide binding]; other site 205918014807 phosphorylation site [posttranslational modification] 205918014808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014809 ATP binding site [chemical binding]; other site 205918014810 Mg2+ binding site [ion binding]; other site 205918014811 G-X-G motif; other site 205918014812 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014813 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014814 Alginate lyase; Region: Alginate_lyase2; pfam08787 205918014815 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918014816 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 205918014817 Fusaric acid resistance protein family; Region: FUSC; pfam04632 205918014818 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 205918014819 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014820 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014821 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014822 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014823 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014824 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014825 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014826 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014827 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014828 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014829 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 205918014830 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014831 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014832 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 205918014833 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918014834 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918014835 1 probable transmembrane helix predicted by TMHMM2.0 205918014836 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918014837 Ion transport protein; Region: Ion_trans; pfam00520 205918014838 Ion channel; Region: Ion_trans_2; pfam07885 205918014839 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 205918014840 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014841 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014842 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014843 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014844 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014845 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014846 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 205918014847 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918014848 1 probable transmembrane helix predicted by TMHMM2.0 205918014849 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 205918014850 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 205918014851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918014852 binding surface 205918014853 TPR motif; other site 205918014854 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014855 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014856 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 205918014857 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014858 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014859 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 205918014860 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 205918014861 catalytic residues [active] 205918014862 central insert; other site 205918014863 1 probable transmembrane helix predicted by TMHMM2.0 205918014864 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 205918014865 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014866 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014867 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014868 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014869 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014870 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014871 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014872 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014873 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014874 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014875 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014876 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014877 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014878 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014879 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014880 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 205918014881 1 probable transmembrane helix predicted by TMHMM2.0 205918014882 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 205918014883 1 probable transmembrane helix predicted by TMHMM2.0 205918014884 heme exporter protein CcmC; Region: ccmC; TIGR01191 205918014885 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014886 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014887 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014888 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014889 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014890 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014891 heme exporter protein CcmB; Region: ccmB; TIGR01190 205918014892 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014893 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014894 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014895 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014896 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014897 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014898 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 205918014899 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 205918014900 Walker A/P-loop; other site 205918014901 ATP binding site [chemical binding]; other site 205918014902 Q-loop/lid; other site 205918014903 ABC transporter signature motif; other site 205918014904 Walker B; other site 205918014905 D-loop; other site 205918014906 H-loop/switch region; other site 205918014907 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 205918014908 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 205918014909 recombination protein RecR; Reviewed; Region: recR; PRK00076 205918014910 RecR protein; Region: RecR; pfam02132 205918014911 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 205918014912 putative active site [active] 205918014913 putative metal-binding site [ion binding]; other site 205918014914 tetramer interface [polypeptide binding]; other site 205918014915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918014916 transcriptional activator TtdR; Provisional; Region: PRK09801 205918014917 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 205918014918 putative effector binding pocket; other site 205918014919 putative dimerization interface [polypeptide binding]; other site 205918014920 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 205918014921 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 205918014922 dimer interface [polypeptide binding]; other site 205918014923 active site 205918014924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918014925 substrate binding site [chemical binding]; other site 205918014926 catalytic residue [active] 205918014927 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918014928 homotrimer interaction site [polypeptide binding]; other site 205918014929 putative active site [active] 205918014930 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918014931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918014932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918014933 Coenzyme A binding pocket [chemical binding]; other site 205918014934 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 205918014935 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918014936 NAD binding site [chemical binding]; other site 205918014937 catalytic residues [active] 205918014938 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 205918014939 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 205918014940 aconitate hydratase; Validated; Region: PRK09277 205918014941 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 205918014942 substrate binding site [chemical binding]; other site 205918014943 ligand binding site [chemical binding]; other site 205918014944 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 205918014945 substrate binding site [chemical binding]; other site 205918014946 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014947 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014948 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014949 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014950 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014951 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014952 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014953 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014954 PAS domain; Region: PAS_9; pfam13426 205918014955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918014956 putative active site [active] 205918014957 heme pocket [chemical binding]; other site 205918014958 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918014959 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014960 dimer interface [polypeptide binding]; other site 205918014961 putative CheW interface [polypeptide binding]; other site 205918014962 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014963 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014964 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 205918014965 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918014966 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918014967 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 205918014968 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 205918014969 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 205918014970 1 probable transmembrane helix predicted by TMHMM2.0 205918014971 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 205918014972 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 205918014973 Low-spin heme binding site [chemical binding]; other site 205918014974 Putative water exit pathway; other site 205918014975 Binuclear center (active site) [active] 205918014976 Putative proton exit pathway; other site 205918014977 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014978 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014979 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014980 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014981 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014982 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014983 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014984 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014985 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014986 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014987 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014988 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014989 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 205918014990 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 205918014991 1 probable transmembrane helix predicted by TMHMM2.0 205918014992 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 205918014993 1 probable transmembrane helix predicted by TMHMM2.0 205918014994 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 205918014995 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 205918014996 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 205918014997 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014998 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014999 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 205918015000 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 205918015001 oligomeric interface; other site 205918015002 putative active site [active] 205918015003 homodimer interface [polypeptide binding]; other site 205918015004 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 205918015005 4Fe-4S binding domain; Region: Fer4_5; pfam12801 205918015006 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 205918015007 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 205918015008 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015009 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015010 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015011 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015012 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 205918015014 FixH; Region: FixH; pfam05751 205918015015 1 probable transmembrane helix predicted by TMHMM2.0 205918015016 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 205918015017 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 205918015018 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918015019 metal-binding site [ion binding] 205918015020 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918015021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918015022 motif II; other site 205918015023 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015024 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015025 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015026 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015027 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015028 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015029 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015030 Uncharacterized conserved protein [Function unknown]; Region: COG2836 205918015031 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015032 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015033 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015034 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015035 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015036 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015037 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 205918015038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918015039 FeS/SAM binding site; other site 205918015040 HemN C-terminal domain; Region: HemN_C; pfam06969 205918015041 molecular chaperone DnaK; Provisional; Region: PRK13411 205918015042 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 205918015043 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918015044 ligand binding site [chemical binding]; other site 205918015045 flexible hinge region; other site 205918015046 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205918015047 putative switch regulator; other site 205918015048 non-specific DNA interactions [nucleotide binding]; other site 205918015049 DNA binding site [nucleotide binding] 205918015050 sequence specific DNA binding site [nucleotide binding]; other site 205918015051 putative cAMP binding site [chemical binding]; other site 205918015052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918015053 active site 205918015054 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 205918015055 1 probable transmembrane helix predicted by TMHMM2.0 205918015056 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 205918015057 putative CheA interaction surface; other site 205918015058 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918015059 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918015060 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918015061 P-loop; other site 205918015062 Magnesium ion binding site [ion binding]; other site 205918015063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918015064 Magnesium ion binding site [ion binding]; other site 205918015065 flagellar motor protein MotD; Reviewed; Region: PRK09038 205918015066 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 205918015067 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918015068 ligand binding site [chemical binding]; other site 205918015069 1 probable transmembrane helix predicted by TMHMM2.0 205918015070 flagellar motor protein; Reviewed; Region: motC; PRK09109 205918015071 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 205918015072 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015073 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015074 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015075 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015076 Response regulator receiver domain; Region: Response_reg; pfam00072 205918015077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015078 active site 205918015079 phosphorylation site [posttranslational modification] 205918015080 intermolecular recognition site; other site 205918015081 dimerization interface [polypeptide binding]; other site 205918015082 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 205918015083 CheB methylesterase; Region: CheB_methylest; pfam01339 205918015084 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918015085 putative binding surface; other site 205918015086 active site 205918015087 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 205918015088 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 205918015089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015090 ATP binding site [chemical binding]; other site 205918015091 Mg2+ binding site [ion binding]; other site 205918015092 G-X-G motif; other site 205918015093 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 205918015094 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 205918015095 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 205918015096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015097 active site 205918015098 phosphorylation site [posttranslational modification] 205918015099 intermolecular recognition site; other site 205918015100 dimerization interface [polypeptide binding]; other site 205918015101 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 205918015102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918015103 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205918015104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918015105 DNA binding residues [nucleotide binding] 205918015106 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 205918015107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918015108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918015109 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 205918015110 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 205918015111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918015112 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 205918015113 FHIPEP family; Region: FHIPEP; pfam00771 205918015114 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015115 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015116 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015117 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015118 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015119 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015120 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015121 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 205918015122 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 205918015123 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015124 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015125 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015126 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015127 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 205918015128 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015129 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015130 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015131 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015132 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015133 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015134 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 205918015135 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015136 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015137 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 205918015138 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015139 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015140 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015141 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015142 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015143 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 205918015144 1 probable transmembrane helix predicted by TMHMM2.0 205918015145 flagellar motor switch protein; Validated; Region: fliN; PRK05698 205918015146 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 205918015147 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 205918015148 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 205918015149 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 205918015150 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015151 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015152 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 205918015153 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918015154 putative binding surface; other site 205918015155 active site 205918015156 Response regulator receiver domain; Region: Response_reg; pfam00072 205918015157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015158 active site 205918015159 phosphorylation site [posttranslational modification] 205918015160 intermolecular recognition site; other site 205918015161 dimerization interface [polypeptide binding]; other site 205918015162 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 205918015163 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 205918015164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918015165 anti sigma factor interaction site; other site 205918015166 regulatory phosphorylation site [posttranslational modification]; other site 205918015167 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 205918015168 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 205918015169 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 205918015170 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 205918015171 Walker A motif/ATP binding site; other site 205918015172 Walker B motif; other site 205918015173 flagellar assembly protein H; Validated; Region: fliH; PRK05687 205918015174 Flagellar assembly protein FliH; Region: FliH; pfam02108 205918015175 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 205918015176 MgtE intracellular N domain; Region: MgtE_N; cl15244 205918015177 FliG C-terminal domain; Region: FliG_C; pfam01706 205918015178 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 205918015179 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 205918015180 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 205918015181 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015182 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015183 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 205918015184 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918015185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015186 active site 205918015187 phosphorylation site [posttranslational modification] 205918015188 intermolecular recognition site; other site 205918015189 dimerization interface [polypeptide binding]; other site 205918015190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918015191 Walker A motif; other site 205918015192 ATP binding site [chemical binding]; other site 205918015193 Walker B motif; other site 205918015194 arginine finger; other site 205918015195 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918015196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918015197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015198 dimer interface [polypeptide binding]; other site 205918015199 phosphorylation site [posttranslational modification] 205918015200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015201 ATP binding site [chemical binding]; other site 205918015202 Mg2+ binding site [ion binding]; other site 205918015203 G-X-G motif; other site 205918015204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918015205 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 205918015206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918015207 Walker A motif; other site 205918015208 ATP binding site [chemical binding]; other site 205918015209 Walker B motif; other site 205918015210 arginine finger; other site 205918015211 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918015212 flagellar protein FliS; Validated; Region: fliS; PRK05685 205918015213 flagellar capping protein; Reviewed; Region: fliD; PRK08032 205918015214 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 205918015215 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 205918015216 FlaG protein; Region: FlaG; pfam03646 205918015217 flagellin; Provisional; Region: PRK12802 205918015218 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 205918015219 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 205918015220 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 205918015221 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 205918015222 dimer interface [polypeptide binding]; other site 205918015223 active site 205918015224 CoA binding pocket [chemical binding]; other site 205918015225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918015226 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 205918015227 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 205918015228 Probable Catalytic site; other site 205918015229 metal-binding site 205918015230 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205918015231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918015232 active site 205918015233 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918015234 active site 205918015235 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 205918015236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918015237 active site 205918015238 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918015239 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 205918015240 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 205918015241 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 205918015242 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 205918015243 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 205918015244 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 205918015245 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 205918015246 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 205918015247 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 205918015248 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 205918015249 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 205918015250 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 205918015251 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 205918015252 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 205918015253 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 205918015254 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 205918015255 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 205918015256 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 205918015257 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 205918015258 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 205918015259 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 205918015260 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 205918015261 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 205918015262 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 205918015263 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 205918015264 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 205918015265 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 205918015266 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 205918015267 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 205918015268 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 205918015269 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 205918015270 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 205918015271 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 205918015272 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 205918015273 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 205918015274 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 205918015275 SnoaL-like domain; Region: SnoaL_2; pfam12680 205918015276 cyanate hydratase; Validated; Region: PRK02866 205918015277 Helix-turn-helix domain; Region: HTH_31; pfam13560 205918015278 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 205918015279 oligomer interface [polypeptide binding]; other site 205918015280 active site 205918015281 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 205918015282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918015283 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 205918015284 dimerization interface [polypeptide binding]; other site 205918015285 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 205918015286 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918015287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918015288 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 205918015289 Response regulator receiver domain; Region: Response_reg; pfam00072 205918015290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015291 active site 205918015292 phosphorylation site [posttranslational modification] 205918015293 intermolecular recognition site; other site 205918015294 dimerization interface [polypeptide binding]; other site 205918015295 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 205918015296 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 205918015297 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 205918015298 FlgN protein; Region: FlgN; pfam05130 205918015299 Flagellar regulator YcgR; Region: YcgR; pfam07317 205918015300 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 205918015301 PilZ domain; Region: PilZ; pfam07238 205918015302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918015303 putative substrate translocation pore; other site 205918015304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918015305 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015306 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015307 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015308 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015309 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015310 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015311 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015312 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015313 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015314 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015315 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015316 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015317 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205918015318 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918015319 Methyltransferase domain; Region: Methyltransf_11; pfam08241 205918015320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918015321 active site 205918015322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015323 ATP binding site [chemical binding]; other site 205918015324 Mg2+ binding site [ion binding]; other site 205918015325 G-X-G motif; other site 205918015326 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 205918015327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015328 active site 205918015329 phosphorylation site [posttranslational modification] 205918015330 intermolecular recognition site; other site 205918015331 dimerization interface [polypeptide binding]; other site 205918015332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918015333 binding surface 205918015334 TPR motif; other site 205918015335 TPR repeat; Region: TPR_11; pfam13414 205918015336 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 205918015337 Bacterial SH3 domain homologues; Region: SH3b; smart00287 205918015338 1 probable transmembrane helix predicted by TMHMM2.0 205918015339 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 205918015340 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 205918015341 Helix-turn-helix domain; Region: HTH_18; pfam12833 205918015342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015343 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 205918015344 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 205918015345 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 205918015346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918015347 putative substrate translocation pore; other site 205918015348 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015349 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015350 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015351 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015352 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015353 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015354 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015355 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015356 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015357 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015358 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015359 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015360 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015361 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015362 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015363 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015364 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015365 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015366 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015367 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 205918015368 GAF domain; Region: GAF; pfam01590 205918015369 Phytochrome region; Region: PHY; pfam00360 205918015370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015371 dimer interface [polypeptide binding]; other site 205918015372 phosphorylation site [posttranslational modification] 205918015373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015374 ATP binding site [chemical binding]; other site 205918015375 Mg2+ binding site [ion binding]; other site 205918015376 G-X-G motif; other site 205918015377 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 205918015378 heme binding pocket [chemical binding]; other site 205918015379 heme ligand [chemical binding]; other site 205918015380 Sulfatase; Region: Sulfatase; pfam00884 205918015381 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015382 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015383 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015384 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015385 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015386 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015387 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015388 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015389 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015390 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015391 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015392 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 205918015393 BNR repeat-like domain; Region: BNR_2; pfam13088 205918015394 1 probable transmembrane helix predicted by TMHMM2.0 205918015395 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 205918015396 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015397 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015398 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015399 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015400 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 205918015401 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 205918015402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015403 active site 205918015404 phosphorylation site [posttranslational modification] 205918015405 intermolecular recognition site; other site 205918015406 dimerization interface [polypeptide binding]; other site 205918015407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918015408 DNA binding site [nucleotide binding] 205918015409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918015410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918015411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015412 dimer interface [polypeptide binding]; other site 205918015413 phosphorylation site [posttranslational modification] 205918015414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015415 ATP binding site [chemical binding]; other site 205918015416 Mg2+ binding site [ion binding]; other site 205918015417 G-X-G motif; other site 205918015418 1 probable transmembrane helix predicted by TMHMM2.0 205918015419 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918015420 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918015421 aldehyde dehydrogenase family 7 member; Region: PLN02315 205918015422 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 205918015423 tetrameric interface [polypeptide binding]; other site 205918015424 NAD binding site [chemical binding]; other site 205918015425 catalytic residues [active] 205918015426 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 205918015427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918015428 inhibitor-cofactor binding pocket; inhibition site 205918015429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015430 catalytic residue [active] 205918015431 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 205918015432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 205918015433 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 205918015434 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015435 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015436 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015437 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015438 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015439 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015440 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015441 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015442 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015443 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015444 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918015446 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918015447 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 205918015448 dimerization interface [polypeptide binding]; other site 205918015449 substrate binding pocket [chemical binding]; other site 205918015450 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 205918015451 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 205918015452 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 205918015453 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 205918015454 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 205918015455 metal binding site [ion binding]; metal-binding site 205918015456 putative dimer interface [polypeptide binding]; other site 205918015457 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918015458 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205918015459 NAD(P) binding site [chemical binding]; other site 205918015460 catalytic residues [active] 205918015461 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 205918015462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 205918015463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918015464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918015465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918015466 dimerization interface [polypeptide binding]; other site 205918015467 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 205918015468 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205918015469 NAD binding site [chemical binding]; other site 205918015470 catalytic Zn binding site [ion binding]; other site 205918015471 structural Zn binding site [ion binding]; other site 205918015472 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 205918015473 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918015474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918015475 DNA-binding site [nucleotide binding]; DNA binding site 205918015476 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 205918015477 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 205918015478 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 205918015479 Na binding site [ion binding]; other site 205918015480 putative substrate binding site [chemical binding]; other site 205918015481 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015482 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015483 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015484 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015485 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015486 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015487 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015488 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015489 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015490 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015491 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015492 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015493 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918015494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918015495 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 205918015496 putative active site [active] 205918015497 heme pocket [chemical binding]; other site 205918015498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918015499 putative active site [active] 205918015500 heme pocket [chemical binding]; other site 205918015501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918015502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015503 dimer interface [polypeptide binding]; other site 205918015504 phosphorylation site [posttranslational modification] 205918015505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015506 ATP binding site [chemical binding]; other site 205918015507 Mg2+ binding site [ion binding]; other site 205918015508 G-X-G motif; other site 205918015509 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918015510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015511 active site 205918015512 phosphorylation site [posttranslational modification] 205918015513 intermolecular recognition site; other site 205918015514 dimerization interface [polypeptide binding]; other site 205918015515 Cache domain; Region: Cache_1; pfam02743 205918015516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918015517 dimerization interface [polypeptide binding]; other site 205918015518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918015519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918015520 dimer interface [polypeptide binding]; other site 205918015521 putative CheW interface [polypeptide binding]; other site 205918015522 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015523 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015524 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 205918015525 putative metal binding site [ion binding]; other site 205918015526 Uncharacterized conserved protein [Function unknown]; Region: COG1432 205918015527 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 205918015528 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918015529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918015530 TAP-like protein; Region: Abhydrolase_4; pfam08386 205918015531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918015532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918015533 WHG domain; Region: WHG; pfam13305 205918015534 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 205918015535 classical (c) SDRs; Region: SDR_c; cd05233 205918015536 NAD(P) binding site [chemical binding]; other site 205918015537 active site 205918015538 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918015539 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 205918015540 putative NAD(P) binding site [chemical binding]; other site 205918015541 short chain dehydrogenase; Provisional; Region: PRK06179 205918015542 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 205918015543 NADP binding site [chemical binding]; other site 205918015544 active site 205918015545 steroid binding site; other site 205918015546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918015547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015548 NAD(P) binding site [chemical binding]; other site 205918015549 active site 205918015550 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918015551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015552 Helix-turn-helix domain; Region: HTH_18; pfam12833 205918015553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015554 Uncharacterized conserved protein [Function unknown]; Region: COG3268 205918015555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918015557 NAD(P) binding site [chemical binding]; other site 205918015558 active site 205918015559 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918015560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015561 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918015562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918015563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918015564 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918015565 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 205918015566 putative C-terminal domain interface [polypeptide binding]; other site 205918015567 putative GSH binding site (G-site) [chemical binding]; other site 205918015568 putative dimer interface [polypeptide binding]; other site 205918015569 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 205918015570 N-terminal domain interface [polypeptide binding]; other site 205918015571 dimer interface [polypeptide binding]; other site 205918015572 substrate binding pocket (H-site) [chemical binding]; other site 205918015573 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 205918015574 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 205918015575 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918015576 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015577 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015578 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015579 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015580 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015581 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015582 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015583 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015584 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015585 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015586 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015587 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015588 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015589 Arc-like DNA binding domain; Region: Arc; pfam03869 205918015590 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 205918015591 MgtE intracellular N domain; Region: MgtE_N; smart00924 205918015592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 205918015593 Divalent cation transporter; Region: MgtE; cl00786 205918015594 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015595 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015596 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015597 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015598 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015599 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918015600 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 205918015601 carbon storage regulator; Provisional; Region: PRK01712 205918015602 aspartate kinase; Reviewed; Region: PRK06635 205918015603 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 205918015604 putative nucleotide binding site [chemical binding]; other site 205918015605 putative catalytic residues [active] 205918015606 putative Mg ion binding site [ion binding]; other site 205918015607 putative aspartate binding site [chemical binding]; other site 205918015608 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 205918015609 putative allosteric regulatory site; other site 205918015610 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 205918015611 putative allosteric regulatory residue; other site 205918015612 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 205918015613 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 205918015614 motif 1; other site 205918015615 active site 205918015616 motif 2; other site 205918015617 motif 3; other site 205918015618 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 205918015619 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 205918015620 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 205918015621 tetramer interface [polypeptide binding]; other site 205918015622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015623 catalytic residue [active] 205918015624 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 205918015625 active site 205918015626 homopentamer interface [polypeptide binding]; other site 205918015627 dimer interface [polypeptide binding]; other site 205918015628 succinylglutamate desuccinylase; Provisional; Region: PRK05324 205918015629 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 205918015630 active site 205918015631 Zn binding site [ion binding]; other site 205918015632 succinylarginine dihydrolase; Provisional; Region: PRK13281 205918015633 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 205918015634 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 205918015635 NAD(P) binding site [chemical binding]; other site 205918015636 catalytic residues [active] 205918015637 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 205918015638 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 205918015639 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 205918015640 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 205918015641 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 205918015642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918015643 inhibitor-cofactor binding pocket; inhibition site 205918015644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015645 catalytic residue [active] 205918015646 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918015647 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 205918015648 conserved cys residue [active] 205918015649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015651 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 205918015652 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918015653 Walker A/P-loop; other site 205918015654 ATP binding site [chemical binding]; other site 205918015655 Q-loop/lid; other site 205918015656 ABC transporter signature motif; other site 205918015657 Walker B; other site 205918015658 D-loop; other site 205918015659 H-loop/switch region; other site 205918015660 Predicted deacylase [General function prediction only]; Region: COG3608 205918015661 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 205918015662 active site 205918015663 Zn binding site [ion binding]; other site 205918015664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918015665 dimer interface [polypeptide binding]; other site 205918015666 conserved gate region; other site 205918015667 putative PBP binding loops; other site 205918015668 ABC-ATPase subunit interface; other site 205918015669 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015670 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015671 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015672 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015673 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015674 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918015675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918015676 dimer interface [polypeptide binding]; other site 205918015677 conserved gate region; other site 205918015678 putative PBP binding loops; other site 205918015679 ABC-ATPase subunit interface; other site 205918015680 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015681 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015682 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015683 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015684 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015685 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 205918015686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918015687 substrate binding pocket [chemical binding]; other site 205918015688 membrane-bound complex binding site; other site 205918015689 hinge residues; other site 205918015690 acetyl-CoA synthetase; Provisional; Region: PRK00174 205918015691 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 205918015692 active site 205918015693 CoA binding site [chemical binding]; other site 205918015694 acyl-activating enzyme (AAE) consensus motif; other site 205918015695 AMP binding site [chemical binding]; other site 205918015696 acetate binding site [chemical binding]; other site 205918015697 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 205918015698 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 205918015699 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 205918015700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918015701 Walker A motif; other site 205918015702 ATP binding site [chemical binding]; other site 205918015703 Walker B motif; other site 205918015704 arginine finger; other site 205918015705 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 205918015706 cofactor binding site; other site 205918015707 metal binding site [ion binding]; metal-binding site 205918015708 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 205918015709 aromatic arch; other site 205918015710 DCoH dimer interaction site [polypeptide binding]; other site 205918015711 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 205918015712 DCoH tetramer interaction site [polypeptide binding]; other site 205918015713 substrate binding site [chemical binding]; other site 205918015714 major facilitator superfamily transporter; Provisional; Region: PRK05122 205918015715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918015716 putative substrate translocation pore; other site 205918015717 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015718 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015719 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015720 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015721 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015722 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015723 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015725 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015726 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015727 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015728 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015729 hypothetical protein; Provisional; Region: PRK09256 205918015730 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 205918015731 aromatic amino acid transporter; Provisional; Region: PRK10238 205918015732 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015733 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015734 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015735 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015736 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015737 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015738 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015739 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015740 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015741 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015742 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015743 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015744 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 205918015745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918015746 RNA binding surface [nucleotide binding]; other site 205918015747 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 205918015748 probable active site [active] 205918015749 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 205918015750 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 205918015751 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 205918015752 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 205918015753 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 205918015754 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 205918015755 active site 205918015756 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 205918015757 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015758 intracellular septation protein A; Reviewed; Region: PRK00259 205918015759 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015760 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015761 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015762 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015763 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015764 YciI-like protein; Reviewed; Region: PRK11370 205918015765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918015766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015767 active site 205918015768 phosphorylation site [posttranslational modification] 205918015769 intermolecular recognition site; other site 205918015770 dimerization interface [polypeptide binding]; other site 205918015771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918015772 DNA binding site [nucleotide binding] 205918015773 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 205918015774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918015775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918015776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015777 ATP binding site [chemical binding]; other site 205918015778 G-X-G motif; other site 205918015779 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015780 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015781 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 205918015782 putative FMN binding site [chemical binding]; other site 205918015783 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 205918015784 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 205918015785 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015786 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015787 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015788 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015789 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015790 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015791 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015792 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015793 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015794 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015795 Protein of unknown function (DUF962); Region: DUF962; pfam06127 205918015796 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015797 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015798 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918015799 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 205918015800 putative active site [active] 205918015801 putative metal binding site [ion binding]; other site 205918015802 Rdx family; Region: Rdx; cl01407 205918015803 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918015804 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 205918015805 Walker A/P-loop; other site 205918015806 ATP binding site [chemical binding]; other site 205918015807 Q-loop/lid; other site 205918015808 ABC transporter signature motif; other site 205918015809 Walker B; other site 205918015810 D-loop; other site 205918015811 H-loop/switch region; other site 205918015812 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205918015813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918015814 dimer interface [polypeptide binding]; other site 205918015815 conserved gate region; other site 205918015816 putative PBP binding loops; other site 205918015817 ABC-ATPase subunit interface; other site 205918015818 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015819 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015820 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015821 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015822 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015823 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015824 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015825 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015826 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918015827 active site 205918015828 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 205918015829 dimer interface [polypeptide binding]; other site 205918015830 non-prolyl cis peptide bond; other site 205918015831 insertion regions; other site 205918015832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918015833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918015834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918015835 dimerization interface [polypeptide binding]; other site 205918015836 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 205918015837 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 205918015838 active site residue [active] 205918015839 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 205918015840 active site residue [active] 205918015841 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 205918015842 active site residue [active] 205918015843 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 205918015844 active site residue [active] 205918015845 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918015846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918015847 substrate binding pocket [chemical binding]; other site 205918015848 membrane-bound complex binding site; other site 205918015849 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918015850 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 205918015851 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 205918015852 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 205918015853 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 205918015854 molybdopterin cofactor binding site [chemical binding]; other site 205918015855 substrate binding site [chemical binding]; other site 205918015856 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 205918015857 molybdopterin cofactor binding site; other site 205918015858 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 205918015859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918015860 substrate binding pocket [chemical binding]; other site 205918015861 membrane-bound complex binding site; other site 205918015862 hinge residues; other site 205918015863 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918015864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918015865 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918015866 putative effector binding pocket; other site 205918015867 dimerization interface [polypeptide binding]; other site 205918015868 Pirin-related protein [General function prediction only]; Region: COG1741 205918015869 Pirin; Region: Pirin; pfam02678 205918015870 1 probable transmembrane helix predicted by TMHMM2.0 205918015871 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 205918015872 GAF domain; Region: GAF_2; pfam13185 205918015873 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 205918015874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918015875 Walker A motif; other site 205918015876 ATP binding site [chemical binding]; other site 205918015877 Walker B motif; other site 205918015878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015879 dimer interface [polypeptide binding]; other site 205918015880 phosphorylation site [posttranslational modification] 205918015881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015882 ATP binding site [chemical binding]; other site 205918015883 Mg2+ binding site [ion binding]; other site 205918015884 G-X-G motif; other site 205918015885 Response regulator receiver domain; Region: Response_reg; pfam00072 205918015886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015887 active site 205918015888 phosphorylation site [posttranslational modification] 205918015889 intermolecular recognition site; other site 205918015890 dimerization interface [polypeptide binding]; other site 205918015891 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015892 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015893 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015894 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 205918015895 catalytic residues [active] 205918015896 dimer interface [polypeptide binding]; other site 205918015897 methionine sulfoxide reductase B; Provisional; Region: PRK00222 205918015898 SelR domain; Region: SelR; pfam01641 205918015899 aminotransferase AlaT; Validated; Region: PRK09265 205918015900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918015901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015902 homodimer interface [polypeptide binding]; other site 205918015903 catalytic residue [active] 205918015904 heat shock protein HtpX; Provisional; Region: PRK05457 205918015905 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015906 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015907 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015908 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015909 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 205918015910 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 205918015911 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 205918015912 putative active site [active] 205918015913 metal binding site [ion binding]; metal-binding site 205918015914 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 205918015915 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918015916 ATP binding site [chemical binding]; other site 205918015917 Mg++ binding site [ion binding]; other site 205918015918 motif III; other site 205918015919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918015920 nucleotide binding region [chemical binding]; other site 205918015921 ATP-binding site [chemical binding]; other site 205918015922 DbpA RNA binding domain; Region: DbpA; pfam03880 205918015923 spermidine synthase; Provisional; Region: PRK00811 205918015924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918015925 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 205918015926 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 205918015927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918015928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918015929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918015930 dimerization interface [polypeptide binding]; other site 205918015931 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205918015932 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015933 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015934 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015935 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015936 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015937 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015938 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015939 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015940 Transcriptional regulators [Transcription]; Region: MarR; COG1846 205918015941 MarR family; Region: MarR; pfam01047 205918015942 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 205918015943 elongation factor P; Validated; Region: PRK00529 205918015944 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 205918015945 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 205918015946 RNA binding site [nucleotide binding]; other site 205918015947 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 205918015948 RNA binding site [nucleotide binding]; other site 205918015949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 205918015950 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 205918015951 1 probable transmembrane helix predicted by TMHMM2.0 205918015952 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918015953 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 205918015954 serine transporter; Region: stp; TIGR00814 205918015955 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015956 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015957 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015958 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015959 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015960 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015961 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015962 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015963 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015964 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015965 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918015967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918015968 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 205918015969 1 probable transmembrane helix predicted by TMHMM2.0 205918015970 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 205918015971 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 205918015972 NAD(P) binding site [chemical binding]; other site 205918015973 homodimer interface [polypeptide binding]; other site 205918015974 substrate binding site [chemical binding]; other site 205918015975 active site 205918015976 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015977 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015978 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015979 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 205918015980 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 205918015981 Mg++ binding site [ion binding]; other site 205918015982 putative catalytic motif [active] 205918015983 putative substrate binding site [chemical binding]; other site 205918015984 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015985 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015986 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015987 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015988 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015989 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015990 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015991 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015992 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015993 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015994 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918015996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015997 NAD(P) binding site [chemical binding]; other site 205918015998 active site 205918015999 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 205918016000 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 205918016001 Beta-Casp domain; Region: Beta-Casp; smart01027 205918016002 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 205918016003 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016004 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016005 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918016006 IHF dimer interface [polypeptide binding]; other site 205918016007 IHF - DNA interface [nucleotide binding]; other site 205918016008 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 205918016009 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 205918016010 RNA binding site [nucleotide binding]; other site 205918016011 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 205918016012 RNA binding site [nucleotide binding]; other site 205918016013 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 205918016014 RNA binding site [nucleotide binding]; other site 205918016015 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918016016 RNA binding site [nucleotide binding]; other site 205918016017 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918016018 RNA binding site [nucleotide binding]; other site 205918016019 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 205918016020 RNA binding site [nucleotide binding]; other site 205918016021 cytidylate kinase; Provisional; Region: cmk; PRK00023 205918016022 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 205918016023 CMP-binding site; other site 205918016024 The sites determining sugar specificity; other site 205918016025 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 205918016026 prephenate dehydrogenase; Validated; Region: PRK08507 205918016027 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 205918016028 putative active site [active] 205918016029 1 probable transmembrane helix predicted by TMHMM2.0 205918016030 Chorismate mutase type II; Region: CM_2; cl00693 205918016031 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 205918016032 Prephenate dehydratase; Region: PDT; pfam00800 205918016033 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 205918016034 putative L-Phe binding site [chemical binding]; other site 205918016035 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 205918016036 homodimer interface [polypeptide binding]; other site 205918016037 substrate-cofactor binding pocket; other site 205918016038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918016039 catalytic residue [active] 205918016040 DNA gyrase subunit A; Validated; Region: PRK05560 205918016041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 205918016042 CAP-like domain; other site 205918016043 active site 205918016044 primary dimer interface [polypeptide binding]; other site 205918016045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918016046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918016047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918016048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918016049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918016050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918016051 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 205918016052 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 205918016053 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 205918016054 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 205918016055 active site 205918016056 putative substrate binding pocket [chemical binding]; other site 205918016057 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 205918016058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918016059 S-adenosylmethionine binding site [chemical binding]; other site 205918016060 phosphoglycolate phosphatase; Provisional; Region: PRK13222 205918016061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918016062 motif II; other site 205918016063 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 205918016064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918016065 NAD(P) binding site [chemical binding]; other site 205918016066 active site 205918016067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918016068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918016069 metal binding site [ion binding]; metal-binding site 205918016070 active site 205918016071 I-site; other site 205918016072 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 205918016073 PAS domain S-box; Region: sensory_box; TIGR00229 205918016074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918016075 putative active site [active] 205918016076 heme pocket [chemical binding]; other site 205918016077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918016078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918016079 metal binding site [ion binding]; metal-binding site 205918016080 active site 205918016081 I-site; other site 205918016082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918016083 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016084 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016085 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918016086 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918016087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918016088 Walker A/P-loop; other site 205918016089 ATP binding site [chemical binding]; other site 205918016090 Q-loop/lid; other site 205918016091 ABC transporter signature motif; other site 205918016092 Walker B; other site 205918016093 D-loop; other site 205918016094 H-loop/switch region; other site 205918016095 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016096 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016097 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016098 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016099 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016100 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 205918016101 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 205918016102 catalytic residues [active] 205918016103 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 205918016104 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 205918016105 active site residue [active] 205918016106 BolA-like protein; Region: BolA; cl00386 205918016107 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 205918016108 fumarate hydratase; Provisional; Region: PRK12425 205918016109 Class II fumarases; Region: Fumarase_classII; cd01362 205918016110 active site 205918016111 tetramer interface [polypeptide binding]; other site 205918016112 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 205918016113 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918016114 EamA-like transporter family; Region: EamA; pfam00892 205918016115 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016116 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016117 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016118 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016119 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016120 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016121 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016122 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016123 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016124 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016125 Uncharacterized conserved protein [Function unknown]; Region: COG3148 205918016126 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 205918016127 RmuC family; Region: RmuC; pfam02646 205918016128 1 probable transmembrane helix predicted by TMHMM2.0 205918016129 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016130 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016131 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016132 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 205918016133 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 205918016134 catalytic residues [active] 205918016135 dimer interface [polypeptide binding]; other site 205918016136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918016137 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016138 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016139 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016140 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016141 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016142 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016143 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016144 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016145 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016146 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016147 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016148 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016149 cobalamin synthase; Reviewed; Region: cobS; PRK00235 205918016150 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016151 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016152 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016153 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016154 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016155 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205918016157 catalytic core [active] 205918016158 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 205918016159 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 205918016160 putative dimer interface [polypeptide binding]; other site 205918016161 active site pocket [active] 205918016162 putative cataytic base [active] 205918016163 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 205918016164 homotrimer interface [polypeptide binding]; other site 205918016165 Walker A motif; other site 205918016166 GTP binding site [chemical binding]; other site 205918016167 Walker B motif; other site 205918016168 cobyric acid synthase; Provisional; Region: PRK00784 205918016169 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 205918016170 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 205918016171 catalytic triad [active] 205918016172 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 205918016173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918016174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918016175 homodimer interface [polypeptide binding]; other site 205918016176 catalytic residue [active] 205918016177 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 205918016178 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016179 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016180 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 205918016181 putative FMN binding site [chemical binding]; other site 205918016182 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 205918016183 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918016184 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 205918016185 catalytic triad [active] 205918016186 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 205918016187 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 205918016188 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 205918016189 Walker A motif; other site 205918016190 homodimer interface [polypeptide binding]; other site 205918016191 ATP binding site [chemical binding]; other site 205918016192 hydroxycobalamin binding site [chemical binding]; other site 205918016193 Walker B motif; other site 205918016194 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 205918016195 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 205918016196 NlpC/P60 family; Region: NLPC_P60; pfam00877 205918016197 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 205918016198 NlpC/P60 family; Region: NLPC_P60; pfam00877 205918016199 NAD-dependent deacetylase; Provisional; Region: PRK00481 205918016200 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 205918016201 NAD+ binding site [chemical binding]; other site 205918016202 substrate binding site [chemical binding]; other site 205918016203 Zn binding site [ion binding]; other site 205918016204 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 205918016205 DNA replication initiation factor; Validated; Region: PRK05642 205918016206 Walker A motif; other site 205918016207 ATP binding site [chemical binding]; other site 205918016208 Walker B motif; other site 205918016209 arginine finger; other site 205918016210 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205918016211 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918016212 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016213 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016214 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016215 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016216 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016217 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016218 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016219 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 205918016220 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 205918016221 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 205918016222 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 205918016223 dimerization interface [polypeptide binding]; other site 205918016224 putative ATP binding site [chemical binding]; other site 205918016225 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 205918016226 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 205918016227 active site 205918016228 substrate binding site [chemical binding]; other site 205918016229 cosubstrate binding site; other site 205918016230 catalytic site [active] 205918016231 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 205918016232 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 205918016233 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 205918016234 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 205918016235 homodimer interface [polypeptide binding]; other site 205918016236 metal binding site [ion binding]; metal-binding site 205918016237 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 205918016238 homodimer interface [polypeptide binding]; other site 205918016239 active site 205918016240 putative chemical substrate binding site [chemical binding]; other site 205918016241 metal binding site [ion binding]; metal-binding site 205918016242 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 205918016243 HD domain; Region: HD_4; pfam13328 205918016244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205918016245 synthetase active site [active] 205918016246 NTP binding site [chemical binding]; other site 205918016247 metal binding site [ion binding]; metal-binding site 205918016248 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 205918016249 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 205918016250 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 205918016251 TRAM domain; Region: TRAM; pfam01938 205918016252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918016253 S-adenosylmethionine binding site [chemical binding]; other site 205918016254 cysteine synthase B; Region: cysM; TIGR01138 205918016255 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205918016256 dimer interface [polypeptide binding]; other site 205918016257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918016258 catalytic residue [active] 205918016259 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 205918016260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918016261 dimerization interface [polypeptide binding]; other site 205918016262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016263 dimer interface [polypeptide binding]; other site 205918016264 phosphorylation site [posttranslational modification] 205918016265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016266 ATP binding site [chemical binding]; other site 205918016267 Mg2+ binding site [ion binding]; other site 205918016268 G-X-G motif; other site 205918016269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016270 active site 205918016271 phosphorylation site [posttranslational modification] 205918016272 intermolecular recognition site; other site 205918016273 dimerization interface [polypeptide binding]; other site 205918016274 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918016275 putative binding surface; other site 205918016276 active site 205918016277 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016278 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016279 META domain; Region: META; pfam03724 205918016280 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 205918016281 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205918016282 catalytic residues [active] 205918016283 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 205918016284 ArsC family; Region: ArsC; pfam03960 205918016285 catalytic residues [active] 205918016286 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 205918016287 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918016288 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 205918016289 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 205918016290 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 205918016291 Ligand Binding Site [chemical binding]; other site 205918016292 hypothetical protein; Provisional; Region: PRK04860 205918016293 SprT homologues; Region: SprT; cl01182 205918016294 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 205918016295 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 205918016296 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016297 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016298 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016299 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016300 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016301 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016302 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016303 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 205918016305 dimer interface [polypeptide binding]; other site 205918016306 phosphorylation site [posttranslational modification] 205918016307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016308 ATP binding site [chemical binding]; other site 205918016309 Mg2+ binding site [ion binding]; other site 205918016310 G-X-G motif; other site 205918016311 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016312 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918016314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016315 active site 205918016316 phosphorylation site [posttranslational modification] 205918016317 intermolecular recognition site; other site 205918016318 dimerization interface [polypeptide binding]; other site 205918016319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918016320 DNA binding site [nucleotide binding] 205918016321 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 205918016322 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918016323 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918016324 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 205918016325 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 205918016326 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 205918016327 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918016328 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 205918016329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918016330 dimerization interface [polypeptide binding]; other site 205918016331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016332 dimer interface [polypeptide binding]; other site 205918016333 phosphorylation site [posttranslational modification] 205918016334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016335 ATP binding site [chemical binding]; other site 205918016336 Mg2+ binding site [ion binding]; other site 205918016337 G-X-G motif; other site 205918016338 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016339 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918016341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016342 active site 205918016343 phosphorylation site [posttranslational modification] 205918016344 intermolecular recognition site; other site 205918016345 dimerization interface [polypeptide binding]; other site 205918016346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918016347 DNA binding site [nucleotide binding] 205918016348 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 205918016349 ATP cone domain; Region: ATP-cone; pfam03477 205918016350 ATP cone domain; Region: ATP-cone; pfam03477 205918016351 Class I ribonucleotide reductase; Region: RNR_I; cd01679 205918016352 active site 205918016353 dimer interface [polypeptide binding]; other site 205918016354 catalytic residues [active] 205918016355 effector binding site; other site 205918016356 R2 peptide binding site; other site 205918016357 Fic/DOC family; Region: Fic; cl00960 205918016358 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 205918016359 dimer interface [polypeptide binding]; other site 205918016360 putative radical transfer pathway; other site 205918016361 diiron center [ion binding]; other site 205918016362 tyrosyl radical; other site 205918016363 Condensation domain; Region: Condensation; pfam00668 205918016364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918016365 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918016366 acyl-activating enzyme (AAE) consensus motif; other site 205918016367 AMP binding site [chemical binding]; other site 205918016368 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918016369 Condensation domain; Region: Condensation; pfam00668 205918016370 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918016371 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918016372 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918016373 acyl-activating enzyme (AAE) consensus motif; other site 205918016374 AMP binding site [chemical binding]; other site 205918016375 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918016376 Condensation domain; Region: Condensation; pfam00668 205918016377 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918016378 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918016379 acyl-activating enzyme (AAE) consensus motif; other site 205918016380 AMP binding site [chemical binding]; other site 205918016381 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918016382 Condensation domain; Region: Condensation; pfam00668 205918016383 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918016384 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918016385 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 205918016386 acyl-activating enzyme (AAE) consensus motif; other site 205918016387 AMP binding site [chemical binding]; other site 205918016388 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918016389 Condensation domain; Region: Condensation; pfam00668 205918016390 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918016391 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918016392 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918016393 acyl-activating enzyme (AAE) consensus motif; other site 205918016394 AMP binding site [chemical binding]; other site 205918016395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918016396 Condensation domain; Region: Condensation; pfam00668 205918016397 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918016398 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918016399 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918016400 acyl-activating enzyme (AAE) consensus motif; other site 205918016401 AMP binding site [chemical binding]; other site 205918016402 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918016403 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918016404 Ribonucleotide reductase beta chain 205918016405 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 205918016406 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 205918016407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 205918016408 Walker B motif; other site 205918016409 arginine finger; other site 205918016410 BRO family, N-terminal domain; Region: Bro-N; smart01040 205918016411 1 probable transmembrane helix predicted by TMHMM2.0 205918016412 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 205918016413 catalytic triad [active] 205918016414 putative active site [active] 205918016415 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 205918016416 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918016417 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918016418 1 probable transmembrane helix predicted by TMHMM2.0 205918016419 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 205918016420 catalytic triad [active] 205918016421 putative active site [active] 205918016422 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 205918016423 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918016424 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918016425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918016426 PAS domain; Region: PAS_9; pfam13426 205918016427 putative active site [active] 205918016428 heme pocket [chemical binding]; other site 205918016429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918016430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918016431 dimer interface [polypeptide binding]; other site 205918016432 putative CheW interface [polypeptide binding]; other site 205918016433 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016434 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016435 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918016436 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 205918016437 1 probable transmembrane helix predicted by TMHMM2.0 205918016438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918016439 MarR family; Region: MarR_2; pfam12802 205918016440 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 205918016441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016442 ATP binding site [chemical binding]; other site 205918016443 putative Mg++ binding site [ion binding]; other site 205918016444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016445 nucleotide binding region [chemical binding]; other site 205918016446 ATP-binding site [chemical binding]; other site 205918016447 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 205918016448 HRDC domain; Region: HRDC; pfam00570 205918016449 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 205918016450 yecA family protein; Region: ygfB_yecA; TIGR02292 205918016451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 205918016452 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016453 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016454 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 205918016455 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 205918016456 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 205918016457 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 205918016458 Uncharacterized conserved protein [Function unknown]; Region: COG4121 205918016459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918016460 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205918016461 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205918016462 Walker A/P-loop; other site 205918016463 ATP binding site [chemical binding]; other site 205918016464 Q-loop/lid; other site 205918016465 ABC transporter signature motif; other site 205918016466 Walker B; other site 205918016467 D-loop; other site 205918016468 H-loop/switch region; other site 205918016469 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918016470 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016471 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016472 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016473 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016474 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016475 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016476 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016477 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016478 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016479 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016480 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 205918016481 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918016482 1 probable transmembrane helix predicted by TMHMM2.0 205918016483 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 205918016484 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 205918016485 active site 205918016486 dimer interface [polypeptide binding]; other site 205918016487 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 205918016488 Ligand Binding Site [chemical binding]; other site 205918016489 Molecular Tunnel; other site 205918016490 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 205918016491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918016492 Coenzyme A binding pocket [chemical binding]; other site 205918016493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205918016494 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 205918016495 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 205918016496 putative oligomer interface [polypeptide binding]; other site 205918016497 putative active site [active] 205918016498 metal binding site [ion binding]; metal-binding site 205918016499 hypothetical protein; Provisional; Region: PRK00304 205918016500 carbon storage regulator; Provisional; Region: PRK01712 205918016501 hypothetical protein; Provisional; Region: PRK02237 205918016502 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016503 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016504 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016505 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016506 short chain dehydrogenase; Provisional; Region: PRK05650 205918016507 classical (c) SDRs; Region: SDR_c; cd05233 205918016508 NAD(P) binding site [chemical binding]; other site 205918016509 active site 205918016510 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 205918016511 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016512 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016513 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 205918016514 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016515 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016516 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 205918016517 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 205918016518 Na binding site [ion binding]; other site 205918016519 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016520 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016521 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016522 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016523 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016524 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016525 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016526 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016527 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016528 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016529 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016530 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016531 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016532 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918016533 Predicted membrane protein [Function unknown]; Region: COG3162 205918016534 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016535 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016536 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 205918016537 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918016538 VacJ like lipoprotein; Region: VacJ; cl01073 205918016539 hypothetical protein; Provisional; Region: PRK11615 205918016540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918016542 putative substrate translocation pore; other site 205918016543 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016544 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016545 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016546 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016547 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016548 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016549 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016550 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016551 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016552 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016553 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016554 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 205918016555 MASE2 domain; Region: MASE2; pfam05230 205918016556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918016557 metal binding site [ion binding]; metal-binding site 205918016558 active site 205918016559 I-site; other site 205918016560 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016561 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016562 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016563 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918016565 DNA binding residues [nucleotide binding] 205918016566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918016567 dimerization interface [polypeptide binding]; other site 205918016568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016569 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918016570 putative substrate translocation pore; other site 205918016571 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016572 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016573 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016574 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016575 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016576 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016577 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016578 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016579 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016580 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016581 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016582 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016583 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918016584 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918016585 N-terminal plug; other site 205918016586 ligand-binding site [chemical binding]; other site 205918016587 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 205918016588 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 205918016589 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 205918016590 GAF domain; Region: GAF; pfam01590 205918016591 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918016592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918016593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016594 dimer interface [polypeptide binding]; other site 205918016595 phosphorylation site [posttranslational modification] 205918016596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016597 ATP binding site [chemical binding]; other site 205918016598 Mg2+ binding site [ion binding]; other site 205918016599 G-X-G motif; other site 205918016600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918016601 PAS domain; Region: PAS_9; pfam13426 205918016602 putative active site [active] 205918016603 heme pocket [chemical binding]; other site 205918016604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918016605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016606 dimer interface [polypeptide binding]; other site 205918016607 phosphorylation site [posttranslational modification] 205918016608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016609 ATP binding site [chemical binding]; other site 205918016610 Mg2+ binding site [ion binding]; other site 205918016611 G-X-G motif; other site 205918016612 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918016613 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205918016614 nucleoside/Zn binding site; other site 205918016615 dimer interface [polypeptide binding]; other site 205918016616 catalytic motif [active] 205918016617 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 205918016618 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918016619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918016620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918016621 Coenzyme A binding pocket [chemical binding]; other site 205918016622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918016623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205918016624 active site 205918016625 catalytic residues [active] 205918016626 metal binding site [ion binding]; metal-binding site 205918016627 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 205918016628 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016629 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016630 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016631 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016632 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016633 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016634 CsbD-like; Region: CsbD; pfam05532 205918016635 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 205918016636 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016637 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016638 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016639 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016640 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 205918016641 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 205918016642 catalytic residues [active] 205918016643 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 205918016644 S1 domain; Region: S1_2; pfam13509 205918016645 S1 domain; Region: S1_2; pfam13509 205918016646 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 205918016647 helicase 45; Provisional; Region: PTZ00424 205918016648 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918016649 ATP binding site [chemical binding]; other site 205918016650 Mg++ binding site [ion binding]; other site 205918016651 motif III; other site 205918016652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016653 nucleotide binding region [chemical binding]; other site 205918016654 ATP-binding site [chemical binding]; other site 205918016655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918016656 dimerization interface [polypeptide binding]; other site 205918016657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016658 dimer interface [polypeptide binding]; other site 205918016659 phosphorylation site [posttranslational modification] 205918016660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016661 ATP binding site [chemical binding]; other site 205918016662 Mg2+ binding site [ion binding]; other site 205918016663 G-X-G motif; other site 205918016664 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016665 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918016667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016668 active site 205918016669 phosphorylation site [posttranslational modification] 205918016670 intermolecular recognition site; other site 205918016671 dimerization interface [polypeptide binding]; other site 205918016672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918016673 DNA binding site [nucleotide binding] 205918016674 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 205918016675 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918016676 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918016677 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918016678 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 205918016679 Surface antigen; Region: Bac_surface_Ag; pfam01103 205918016680 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 205918016681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918016682 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 205918016683 putative substrate binding pocket [chemical binding]; other site 205918016684 putative dimerization interface [polypeptide binding]; other site 205918016685 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 205918016686 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205918016687 Uncharacterized conserved protein [Function unknown]; Region: COG4925 205918016688 1 probable transmembrane helix predicted by TMHMM2.0 205918016689 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 205918016690 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918016691 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205918016692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016693 putative substrate translocation pore; other site 205918016694 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016695 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016696 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016697 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016698 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016699 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016700 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016701 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016702 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016703 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016704 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016705 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918016707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918016708 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 205918016709 putative effector binding pocket; other site 205918016710 putative dimerization interface [polypeptide binding]; other site 205918016711 1 probable transmembrane helix predicted by TMHMM2.0 205918016712 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205918016713 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918016714 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016715 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016716 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016717 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016718 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016719 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918016720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016721 ATP binding site [chemical binding]; other site 205918016722 putative Mg++ binding site [ion binding]; other site 205918016723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016724 nucleotide binding region [chemical binding]; other site 205918016725 ATP-binding site [chemical binding]; other site 205918016726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918016727 active site 205918016728 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 205918016729 DNA protecting protein DprA; Region: dprA; TIGR00732 205918016730 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 205918016731 putative transposase OrfB; Reviewed; Region: PHA02517 205918016732 HTH-like domain; Region: HTH_21; pfam13276 205918016733 Integrase core domain; Region: rve; pfam00665 205918016734 Integrase core domain; Region: rve_2; pfam13333 205918016735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918016736 Transposase; Region: HTH_Tnp_1; pfam01527 205918016737 mechanosensitive ion channel family protein 205918016738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918016739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918016740 Coenzyme A binding pocket [chemical binding]; other site 205918016741 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 205918016742 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 205918016743 BRO family, N-terminal domain; Region: Bro-N; smart01040 205918016744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918016745 classical (c) SDRs; Region: SDR_c; cd05233 205918016746 NAD(P) binding site [chemical binding]; other site 205918016747 active site 205918016748 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918016749 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016750 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016751 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016752 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016753 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016754 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016755 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016756 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016757 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016758 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016759 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 205918016760 Right handed beta helix region; Region: Beta_helix; pfam13229 205918016761 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 205918016762 Cadherin repeat-like domain; Region: CA_like; cl15786 205918016763 Ca2+ binding site [ion binding]; other site 205918016764 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918016765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918016766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918016767 LysR substrate binding domain; Region: LysR_substrate; pfam03466 205918016768 dimerization interface [polypeptide binding]; other site 205918016769 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 205918016770 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 205918016771 substrate binding site [chemical binding]; other site 205918016772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918016773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205918016774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918016775 Walker A/P-loop; other site 205918016776 ATP binding site [chemical binding]; other site 205918016777 Q-loop/lid; other site 205918016778 ABC transporter signature motif; other site 205918016779 Walker B; other site 205918016780 D-loop; other site 205918016781 H-loop/switch region; other site 205918016782 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016783 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016784 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016785 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016786 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 205918016788 Protein of unknown function, DUF482; Region: DUF482; pfam04339 205918016789 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 205918016790 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 205918016791 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 205918016792 dimer interface [polypeptide binding]; other site 205918016793 active site 205918016794 CoA binding pocket [chemical binding]; other site 205918016795 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 205918016796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016797 ATP binding site [chemical binding]; other site 205918016798 putative Mg++ binding site [ion binding]; other site 205918016799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016800 nucleotide binding region [chemical binding]; other site 205918016801 ATP-binding site [chemical binding]; other site 205918016802 Helicase associated domain (HA2); Region: HA2; pfam04408 205918016803 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 205918016804 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 205918016805 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 205918016806 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 205918016807 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 205918016808 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 205918016809 acyl-activating enzyme (AAE) consensus motif; other site 205918016810 putative AMP binding site [chemical binding]; other site 205918016811 putative active site [active] 205918016812 putative CoA binding site [chemical binding]; other site 205918016813 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 205918016814 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 205918016815 acyl-activating enzyme (AAE) consensus motif; other site 205918016816 putative AMP binding site [chemical binding]; other site 205918016817 putative active site [active] 205918016818 putative CoA binding site [chemical binding]; other site 205918016819 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 205918016820 dimer interaction site [polypeptide binding]; other site 205918016821 substrate-binding tunnel; other site 205918016822 active site 205918016823 catalytic site [active] 205918016824 substrate binding site [chemical binding]; other site 205918016825 Pectate lyase; Region: Pec_lyase_C; cl01593 205918016826 ATP-dependent helicase HepA; Validated; Region: PRK04914 205918016827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016828 ATP binding site [chemical binding]; other site 205918016829 putative Mg++ binding site [ion binding]; other site 205918016830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016831 nucleotide binding region [chemical binding]; other site 205918016832 ATP-binding site [chemical binding]; other site 205918016833 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 205918016834 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 205918016835 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 205918016836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918016837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918016838 metal binding site [ion binding]; metal-binding site 205918016839 active site 205918016840 I-site; other site 205918016841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918016842 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016843 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016844 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016845 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016846 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016847 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016848 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 205918016849 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 205918016850 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 205918016851 dimerization interface [polypeptide binding]; other site 205918016852 ligand binding site [chemical binding]; other site 205918016853 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918016854 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918016855 TM-ABC transporter signature motif; other site 205918016856 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016857 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016858 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016859 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016860 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016861 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016862 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016863 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016864 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 205918016865 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 205918016866 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918016867 TM-ABC transporter signature motif; other site 205918016868 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016869 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016870 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016871 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016872 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016873 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016874 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016875 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016876 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016877 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016878 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 205918016879 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 205918016880 Walker A/P-loop; other site 205918016881 ATP binding site [chemical binding]; other site 205918016882 Q-loop/lid; other site 205918016883 ABC transporter signature motif; other site 205918016884 Walker B; other site 205918016885 D-loop; other site 205918016886 H-loop/switch region; other site 205918016887 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 205918016888 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 205918016889 Walker A/P-loop; other site 205918016890 ATP binding site [chemical binding]; other site 205918016891 Q-loop/lid; other site 205918016892 ABC transporter signature motif; other site 205918016893 Walker B; other site 205918016894 D-loop; other site 205918016895 H-loop/switch region; other site 205918016896 Predicted membrane protein [Function unknown]; Region: COG3650 205918016897 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 205918016898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205918016899 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 205918016900 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016901 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016902 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 205918016903 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 205918016904 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 205918016905 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918016906 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918016907 ligand binding site [chemical binding]; other site 205918016908 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918016909 Beta-lactamase; Region: Beta-lactamase; pfam00144 205918016910 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 205918016911 DEAD/DEAH box helicase; Region: DEAD; pfam00270 205918016912 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 205918016913 Predicted integral membrane protein [Function unknown]; Region: COG5615 205918016914 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016915 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016916 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016917 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016918 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 205918016919 Purine nucleoside permease (NUP); Region: NUP; pfam06516 205918016920 1 probable transmembrane helix predicted by TMHMM2.0 205918016921 1 probable transmembrane helix predicted by TMHMM2.0 205918016922 Protein of unknown function (DUF1145); Region: DUF1145; pfam06611 205918016923 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016924 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918016926 dimerization interface [polypeptide binding]; other site 205918016927 hypothetical protein; Provisional; Region: PRK00183 205918016928 SEC-C motif; Region: SEC-C; pfam02810 205918016929 Secretin and TonB N terminus short domain; Region: STN; smart00965 205918016930 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918016931 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918016932 N-terminal plug; other site 205918016933 ligand-binding site [chemical binding]; other site 205918016934 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 205918016935 1 probable transmembrane helix predicted by TMHMM2.0 205918016936 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016937 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016938 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016939 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 205918016940 Predicted transcriptional regulator [Transcription]; Region: COG2932 205918016941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918016942 non-specific DNA binding site [nucleotide binding]; other site 205918016943 salt bridge; other site 205918016944 sequence-specific DNA binding site [nucleotide binding]; other site 205918016945 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918016946 Catalytic site [active] 205918016947 SEC-C motif; Region: SEC-C; pfam02810 205918016948 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 205918016949 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 205918016950 active site 205918016951 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 205918016952 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918016953 ATP-dependent DNA ligase; Validated; Region: PRK09247 205918016954 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 205918016955 active site 205918016956 DNA binding site [nucleotide binding] 205918016957 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 205918016958 DNA binding site [nucleotide binding] 205918016959 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 205918016960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918016961 substrate binding pocket [chemical binding]; other site 205918016962 membrane-bound complex binding site; other site 205918016963 hinge residues; other site 205918016964 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918016965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918016966 dimer interface [polypeptide binding]; other site 205918016967 conserved gate region; other site 205918016968 putative PBP binding loops; other site 205918016969 ABC-ATPase subunit interface; other site 205918016970 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016971 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016972 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016973 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016974 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016975 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918016976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918016977 dimer interface [polypeptide binding]; other site 205918016978 conserved gate region; other site 205918016979 putative PBP binding loops; other site 205918016980 ABC-ATPase subunit interface; other site 205918016981 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016982 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016983 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016984 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016985 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016986 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 205918016987 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 205918016988 active site 205918016989 Zn binding site [ion binding]; other site 205918016990 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 205918016991 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918016992 Walker A/P-loop; other site 205918016993 ATP binding site [chemical binding]; other site 205918016994 Q-loop/lid; other site 205918016995 ABC transporter signature motif; other site 205918016996 Walker B; other site 205918016997 D-loop; other site 205918016998 H-loop/switch region; other site 205918016999 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 205918017000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 205918017001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918017002 ATP binding site [chemical binding]; other site 205918017003 putative Mg++ binding site [ion binding]; other site 205918017004 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918017005 nucleotide binding region [chemical binding]; other site 205918017006 ATP-binding site [chemical binding]; other site 205918017007 DEAD/H associated; Region: DEAD_assoc; pfam08494 205918017008 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 205918017009 putative active site [active] 205918017010 putative metal binding site [ion binding]; other site 205918017011 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205918017012 trimer interface [polypeptide binding]; other site 205918017013 active site 205918017014 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205918017015 DNA-binding site [nucleotide binding]; DNA binding site 205918017016 RNA-binding motif; other site 205918017017 antiporter inner membrane protein; Provisional; Region: PRK11670 205918017018 Domain of unknown function DUF59; Region: DUF59; pfam01883 205918017019 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 205918017020 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 205918017021 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 205918017022 active site 205918017023 HIGH motif; other site 205918017024 KMSKS motif; other site 205918017025 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 205918017026 tRNA binding surface [nucleotide binding]; other site 205918017027 anticodon binding site; other site 205918017028 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 205918017029 putative tRNA-binding site [nucleotide binding]; other site 205918017030 dimer interface [polypeptide binding]; other site 205918017031 ferredoxin; Provisional; Region: PRK08764 205918017032 Putative Fe-S cluster; Region: FeS; pfam04060 205918017033 4Fe-4S binding domain; Region: Fer4; pfam00037 205918017034 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 205918017035 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205918017036 minor groove reading motif; other site 205918017037 helix-hairpin-helix signature motif; other site 205918017038 substrate binding pocket [chemical binding]; other site 205918017039 active site 205918017040 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 205918017041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918017042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017043 active site 205918017044 phosphorylation site [posttranslational modification] 205918017045 intermolecular recognition site; other site 205918017046 dimerization interface [polypeptide binding]; other site 205918017047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918017048 DNA binding residues [nucleotide binding] 205918017049 dimerization interface [polypeptide binding]; other site 205918017050 argininosuccinate synthase; Provisional; Region: PRK13820 205918017051 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 205918017052 ANP binding site [chemical binding]; other site 205918017053 Substrate Binding Site II [chemical binding]; other site 205918017054 Substrate Binding Site I [chemical binding]; other site 205918017055 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918017056 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918017057 ligand binding site [chemical binding]; other site 205918017058 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 205918017059 active site 205918017060 substrate binding pocket [chemical binding]; other site 205918017061 dimer interface [polypeptide binding]; other site 205918017062 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 205918017063 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 205918017064 dimer interface [polypeptide binding]; other site 205918017065 catalytic site [active] 205918017066 putative active site [active] 205918017067 putative substrate binding site [chemical binding]; other site 205918017068 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 205918017069 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 205918017070 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 205918017071 heme binding site [chemical binding]; other site 205918017072 ferroxidase pore; other site 205918017073 ferroxidase diiron center [ion binding]; other site 205918017074 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 205918017075 putative GSH binding site [chemical binding]; other site 205918017076 catalytic residues [active] 205918017077 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 205918017078 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 205918017079 putative [Fe4-S4] binding site [ion binding]; other site 205918017080 putative molybdopterin cofactor binding site [chemical binding]; other site 205918017081 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 205918017082 putative molybdopterin cofactor binding site; other site 205918017083 ornithine carbamoyltransferase; Provisional; Region: PRK00779 205918017084 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205918017085 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205918017086 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918017087 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 205918017088 Walker A/P-loop; other site 205918017089 ATP binding site [chemical binding]; other site 205918017090 Q-loop/lid; other site 205918017091 ABC transporter signature motif; other site 205918017092 Walker B; other site 205918017093 D-loop; other site 205918017094 H-loop/switch region; other site 205918017095 TOBE domain; Region: TOBE_2; pfam08402 205918017096 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 205918017097 putative deacylase active site [active] 205918017098 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 205918017099 amphipathic channel; other site 205918017100 Asn-Pro-Ala signature motifs; other site 205918017101 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017102 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017103 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017104 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017105 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017106 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017107 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017108 glycerol kinase; Provisional; Region: glpK; PRK00047 205918017109 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 205918017110 N- and C-terminal domain interface [polypeptide binding]; other site 205918017111 active site 205918017112 MgATP binding site [chemical binding]; other site 205918017113 catalytic site [active] 205918017114 metal binding site [ion binding]; metal-binding site 205918017115 glycerol binding site [chemical binding]; other site 205918017116 homotetramer interface [polypeptide binding]; other site 205918017117 homodimer interface [polypeptide binding]; other site 205918017118 protein IIAGlc interface [polypeptide binding]; other site 205918017119 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 205918017120 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 205918017121 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 205918017122 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 205918017123 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 205918017124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918017125 substrate binding pocket [chemical binding]; other site 205918017126 membrane-bound complex binding site; other site 205918017127 hinge residues; other site 205918017128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017129 dimer interface [polypeptide binding]; other site 205918017130 conserved gate region; other site 205918017131 putative PBP binding loops; other site 205918017132 ABC-ATPase subunit interface; other site 205918017133 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017134 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017135 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017136 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017138 dimer interface [polypeptide binding]; other site 205918017139 conserved gate region; other site 205918017140 putative PBP binding loops; other site 205918017141 ABC-ATPase subunit interface; other site 205918017142 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017143 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017144 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017145 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017146 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017147 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918017148 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205918017149 Walker A/P-loop; other site 205918017150 ATP binding site [chemical binding]; other site 205918017151 Q-loop/lid; other site 205918017152 ABC transporter signature motif; other site 205918017153 Walker B; other site 205918017154 D-loop; other site 205918017155 H-loop/switch region; other site 205918017156 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 205918017157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017158 dimer interface [polypeptide binding]; other site 205918017159 phosphorylation site [posttranslational modification] 205918017160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017161 ATP binding site [chemical binding]; other site 205918017162 Mg2+ binding site [ion binding]; other site 205918017163 G-X-G motif; other site 205918017164 1 probable transmembrane helix predicted by TMHMM2.0 205918017165 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918017166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017167 active site 205918017168 phosphorylation site [posttranslational modification] 205918017169 intermolecular recognition site; other site 205918017170 dimerization interface [polypeptide binding]; other site 205918017171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918017172 Walker A motif; other site 205918017173 ATP binding site [chemical binding]; other site 205918017174 Walker B motif; other site 205918017175 arginine finger; other site 205918017176 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918017177 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 205918017178 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 205918017179 catalytic residues [active] 205918017180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918017181 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 205918017182 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 205918017183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918017184 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 205918017185 putative dimerization interface [polypeptide binding]; other site 205918017186 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 205918017187 nudix motif; other site 205918017188 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 205918017189 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 205918017190 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 205918017191 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 205918017192 OpgC protein; Region: OpgC_C; pfam10129 205918017193 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017194 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017195 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017196 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017197 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017198 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017199 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017200 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017201 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017202 1 probable transmembrane helix predicted by TMHMM2.0 205918017203 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 205918017204 Transglycosylase; Region: Transgly; pfam00912 205918017205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 205918017206 1 probable transmembrane helix predicted by TMHMM2.0 205918017207 Predicted transcriptional regulators [Transcription]; Region: COG1695 205918017208 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 205918017209 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 205918017210 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 205918017211 FAD binding pocket [chemical binding]; other site 205918017212 FAD binding motif [chemical binding]; other site 205918017213 phosphate binding motif [ion binding]; other site 205918017214 NAD binding pocket [chemical binding]; other site 205918017215 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017216 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017217 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017218 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017219 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017220 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017221 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 205918017222 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 205918017223 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 205918017224 Trp docking motif [polypeptide binding]; other site 205918017225 putative active site [active] 205918017226 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017227 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017228 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017229 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017230 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017231 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918017232 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 205918017233 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918017234 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 205918017235 classical (c) SDRs; Region: SDR_c; cd05233 205918017236 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918017237 NAD(P) binding site [chemical binding]; other site 205918017238 active site 205918017239 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918017240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017241 NAD(P) binding site [chemical binding]; other site 205918017242 active site 205918017243 1 probable transmembrane helix predicted by TMHMM2.0 205918017244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017245 benzoate transport; Region: 2A0115; TIGR00895 205918017246 putative substrate translocation pore; other site 205918017247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017248 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017249 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017250 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017251 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017252 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017253 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017254 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017255 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017256 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017257 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017258 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017259 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017260 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 205918017261 active site 205918017262 catalytic site [active] 205918017263 Zn binding site [ion binding]; other site 205918017264 tetramer interface [polypeptide binding]; other site 205918017265 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 205918017266 hypothetical protein; Provisional; Region: PRK06102 205918017267 Amidase; Region: Amidase; cl11426 205918017268 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918017269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918017270 DNA-binding site [nucleotide binding]; DNA binding site 205918017271 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918017272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918017273 DNA-binding site [nucleotide binding]; DNA binding site 205918017274 FCD domain; Region: FCD; pfam07729 205918017275 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 205918017276 apolar tunnel; other site 205918017277 heme binding site [chemical binding]; other site 205918017278 dimerization interface [polypeptide binding]; other site 205918017279 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 205918017280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918017281 dimerization interface [polypeptide binding]; other site 205918017282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918017283 metal binding site [ion binding]; metal-binding site 205918017284 active site 205918017285 I-site; other site 205918017286 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918017287 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017288 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017289 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 205918017290 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 205918017291 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 205918017292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918017293 Walker A motif; other site 205918017294 ATP binding site [chemical binding]; other site 205918017295 Walker B motif; other site 205918017296 arginine finger; other site 205918017297 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205918017298 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 205918017299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918017300 S-adenosylmethionine binding site [chemical binding]; other site 205918017301 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918017302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918017303 S-adenosylmethionine binding site [chemical binding]; other site 205918017304 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 205918017305 active site 205918017306 hydrophilic channel; other site 205918017307 dimerization interface [polypeptide binding]; other site 205918017308 catalytic residues [active] 205918017309 active site lid [active] 205918017310 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 205918017311 Recombination protein O N terminal; Region: RecO_N; pfam11967 205918017312 Recombination protein O C terminal; Region: RecO_C; pfam02565 205918017313 GTPase Era; Reviewed; Region: era; PRK00089 205918017314 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 205918017315 G1 box; other site 205918017316 GTP/Mg2+ binding site [chemical binding]; other site 205918017317 Switch I region; other site 205918017318 G2 box; other site 205918017319 Switch II region; other site 205918017320 G3 box; other site 205918017321 G4 box; other site 205918017322 G5 box; other site 205918017323 ribonuclease III; Reviewed; Region: rnc; PRK00102 205918017324 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 205918017325 dimerization interface [polypeptide binding]; other site 205918017326 active site 205918017327 metal binding site [ion binding]; metal-binding site 205918017328 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 205918017329 dsRNA binding site [nucleotide binding]; other site 205918017330 1 probable transmembrane helix predicted by TMHMM2.0 205918017331 signal peptidase I; Provisional; Region: PRK10861 205918017332 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205918017333 Catalytic site [active] 205918017334 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205918017335 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017336 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017337 GTP-binding protein LepA; Provisional; Region: PRK05433 205918017338 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 205918017339 G1 box; other site 205918017340 putative GEF interaction site [polypeptide binding]; other site 205918017341 GTP/Mg2+ binding site [chemical binding]; other site 205918017342 Switch I region; other site 205918017343 G2 box; other site 205918017344 G3 box; other site 205918017345 Switch II region; other site 205918017346 G4 box; other site 205918017347 G5 box; other site 205918017348 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 205918017349 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 205918017350 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 205918017351 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 205918017352 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 205918017353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205918017354 protein binding site [polypeptide binding]; other site 205918017355 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205918017356 protein binding site [polypeptide binding]; other site 205918017357 MucB/RseB family; Region: MucB_RseB; pfam03888 205918017358 anti-sigma E factor; Provisional; Region: rseB; PRK09455 205918017359 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 205918017360 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 205918017361 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 205918017362 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 205918017363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918017364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918017365 DNA binding residues [nucleotide binding] 205918017366 L-aspartate oxidase; Provisional; Region: PRK09077 205918017367 L-aspartate oxidase; Provisional; Region: PRK06175 205918017368 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205918017369 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017370 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017371 Uncharacterized conserved protein [Function unknown]; Region: COG2938 205918017372 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 205918017373 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 205918017374 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 205918017375 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 205918017376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918017377 HAMP domain; Region: HAMP; pfam00672 205918017378 dimerization interface [polypeptide binding]; other site 205918017379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017380 dimer interface [polypeptide binding]; other site 205918017381 phosphorylation site [posttranslational modification] 205918017382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017383 ATP binding site [chemical binding]; other site 205918017384 Mg2+ binding site [ion binding]; other site 205918017385 G-X-G motif; other site 205918017386 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017387 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017388 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 205918017389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017390 active site 205918017391 phosphorylation site [posttranslational modification] 205918017392 intermolecular recognition site; other site 205918017393 dimerization interface [polypeptide binding]; other site 205918017394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918017395 DNA binding site [nucleotide binding] 205918017396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 205918017397 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 205918017398 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017399 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017400 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017401 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 205918017403 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017404 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017405 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017406 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017407 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017408 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017409 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017410 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017411 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017412 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017413 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017414 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017415 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918017416 Putative ammonia monooxygenase; Region: AmoA; pfam05145 205918017417 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918017418 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017419 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017420 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017421 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017422 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017423 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017424 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017425 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 205918017426 ligand binding site [chemical binding]; other site 205918017427 active site 205918017428 UGI interface [polypeptide binding]; other site 205918017429 catalytic site [active] 205918017430 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 205918017431 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918017432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918017433 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017434 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017435 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017436 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017437 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017438 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918017439 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 205918017440 Walker A/P-loop; other site 205918017441 ATP binding site [chemical binding]; other site 205918017442 Q-loop/lid; other site 205918017443 ABC transporter signature motif; other site 205918017444 Walker B; other site 205918017445 D-loop; other site 205918017446 H-loop/switch region; other site 205918017447 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 205918017448 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 205918017449 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 205918017450 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 205918017451 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 205918017452 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918017453 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205918017454 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 205918017455 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 205918017456 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 205918017457 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 205918017458 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 205918017459 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918017460 carboxyltransferase (CT) interaction site; other site 205918017461 biotinylation site [posttranslational modification]; other site 205918017462 allophanate hydrolase; Provisional; Region: PRK08186 205918017463 Amidase; Region: Amidase; cl11426 205918017464 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 205918017465 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 205918017466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918017467 RNA binding surface [nucleotide binding]; other site 205918017468 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 205918017469 active site 205918017470 uracil binding [chemical binding]; other site 205918017471 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918017472 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 205918017473 active site 205918017474 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918017475 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918017476 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918017477 Part of AAA domain; Region: AAA_19; pfam13245 205918017478 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 205918017479 AAA domain; Region: AAA_12; pfam13087 205918017480 Amb_all domain; Region: Amb_all; smart00656 205918017481 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918017482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918017483 Coenzyme A binding pocket [chemical binding]; other site 205918017484 putative alcohol dehydrogenase; Provisional; Region: PRK09860 205918017485 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 205918017486 dimer interface [polypeptide binding]; other site 205918017487 active site 205918017488 metal binding site [ion binding]; metal-binding site 205918017489 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918017490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918017491 S-adenosylmethionine binding site [chemical binding]; other site 205918017492 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918017493 Repair protein; Region: Repair_PSII; cl01535 205918017494 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017495 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017496 Repair protein; Region: Repair_PSII; pfam04536 205918017497 1 probable transmembrane helix predicted by TMHMM2.0 205918017498 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205918017499 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 205918017500 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 205918017501 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 205918017502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017503 dimer interface [polypeptide binding]; other site 205918017504 phosphorylation site [posttranslational modification] 205918017505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017506 ATP binding site [chemical binding]; other site 205918017507 Mg2+ binding site [ion binding]; other site 205918017508 G-X-G motif; other site 205918017509 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017510 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017511 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017512 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918017513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017514 active site 205918017515 phosphorylation site [posttranslational modification] 205918017516 intermolecular recognition site; other site 205918017517 dimerization interface [polypeptide binding]; other site 205918017518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918017519 Walker A motif; other site 205918017520 ATP binding site [chemical binding]; other site 205918017521 Walker B motif; other site 205918017522 arginine finger; other site 205918017523 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 205918017524 PAS fold; Region: PAS_4; pfam08448 205918017525 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918017526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918017527 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918017528 putative active site [active] 205918017529 heme pocket [chemical binding]; other site 205918017530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017531 dimer interface [polypeptide binding]; other site 205918017532 phosphorylation site [posttranslational modification] 205918017533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017534 ATP binding site [chemical binding]; other site 205918017535 Mg2+ binding site [ion binding]; other site 205918017536 G-X-G motif; other site 205918017537 Response regulator receiver domain; Region: Response_reg; pfam00072 205918017538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017539 active site 205918017540 phosphorylation site [posttranslational modification] 205918017541 intermolecular recognition site; other site 205918017542 dimerization interface [polypeptide binding]; other site 205918017543 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 205918017544 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 205918017545 nucleotide binding site [chemical binding]; other site 205918017546 putative NEF/HSP70 interaction site [polypeptide binding]; other site 205918017547 SBD interface [polypeptide binding]; other site 205918017548 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918017549 HSP70 interaction site [polypeptide binding]; other site 205918017550 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017551 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017552 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017553 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017554 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 205918017555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017556 putative substrate translocation pore; other site 205918017557 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017558 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017559 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017560 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017561 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017562 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017563 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017564 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017565 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017566 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017567 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017568 1 probable transmembrane helix predicted by TMHMM2.0 205918017569 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 205918017570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918017572 putative substrate translocation pore; other site 205918017573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017574 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017575 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017576 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017577 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017578 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017579 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017580 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017581 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017582 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017583 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017584 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017585 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017586 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918017587 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 205918017588 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 205918017589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918017590 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 205918017591 1 probable transmembrane helix predicted by TMHMM2.0 205918017592 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 205918017593 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918017594 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918017595 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 205918017596 Protein export membrane protein; Region: SecD_SecF; cl14618 205918017597 Protein export membrane protein; Region: SecD_SecF; cl14618 205918017598 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017599 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017600 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017601 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017602 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017603 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017604 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017605 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017606 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017607 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017608 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017609 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918017610 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 205918017611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017612 putative substrate translocation pore; other site 205918017613 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017614 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017615 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017616 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017617 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017618 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017619 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017620 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017621 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017622 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017623 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017624 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017625 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 205918017626 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918017627 dimer interface [polypeptide binding]; other site 205918017628 active site 205918017629 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 205918017630 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 205918017631 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 205918017632 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 205918017633 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918017634 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 205918017635 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 205918017636 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017637 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017638 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017639 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017640 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017641 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017642 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017643 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017644 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017645 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017646 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 205918017647 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 205918017648 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 205918017649 putative active site [active] 205918017650 putative substrate binding site [chemical binding]; other site 205918017651 putative cosubstrate binding site; other site 205918017652 catalytic site [active] 205918017653 exonuclease I; Provisional; Region: sbcB; PRK11779 205918017654 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 205918017655 active site 205918017656 catalytic site [active] 205918017657 substrate binding site [chemical binding]; other site 205918017658 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 205918017659 Predicted membrane protein/domain [Function unknown]; Region: COG1714 205918017660 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017661 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017662 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 205918017663 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017664 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017665 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017666 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017667 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017668 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017669 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017670 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017671 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017672 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017673 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017674 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 205918017675 1 probable transmembrane helix predicted by TMHMM2.0 205918017676 MoxR-like ATPases [General function prediction only]; Region: COG0714 205918017677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918017678 Walker A motif; other site 205918017679 ATP binding site [chemical binding]; other site 205918017680 Walker B motif; other site 205918017681 arginine finger; other site 205918017682 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205918017683 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205918017684 metal ion-dependent adhesion site (MIDAS); other site 205918017685 PilZ domain; Region: PilZ; pfam07238 205918017686 pyruvate kinase; Provisional; Region: PRK05826 205918017687 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 205918017688 domain interfaces; other site 205918017689 active site 205918017690 hypothetical protein; Provisional; Region: PRK05713 205918017691 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918017692 catalytic loop [active] 205918017693 iron binding site [ion binding]; other site 205918017694 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 205918017695 FAD binding pocket [chemical binding]; other site 205918017696 conserved FAD binding motif [chemical binding]; other site 205918017697 phosphate binding motif [ion binding]; other site 205918017698 beta-alpha-beta structure motif; other site 205918017699 NAD binding pocket [chemical binding]; other site 205918017700 putative fumarate hydratase; Provisional; Region: PRK15392 205918017701 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 205918017702 Fumarase C-terminus; Region: Fumerase_C; pfam05683 205918017703 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017704 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017705 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017706 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017707 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 205918017708 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 205918017709 Family description; Region: VCBS; pfam13517 205918017710 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 205918017711 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 205918017712 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017713 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017714 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017715 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017716 Protein of unknown function (DUF796); Region: DUF796; pfam05638 205918017717 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 205918017718 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 205918017719 putative active site [active] 205918017720 catalytic site [active] 205918017721 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 205918017722 PLD-like domain; Region: PLDc_2; pfam13091 205918017723 putative active site [active] 205918017724 catalytic site [active] 205918017725 YceI-like domain; Region: YceI; pfam04264 205918017726 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017727 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017728 1 probable transmembrane helix predicted by TMHMM2.0 205918017729 Beta-lactamase; Region: Beta-lactamase; pfam00144 205918017730 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918017731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 205918017732 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918017733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918017734 putative acyl-acceptor binding pocket; other site 205918017735 1 probable transmembrane helix predicted by TMHMM2.0 205918017736 Protein of unknown function, DUF479; Region: DUF479; cl01203 205918017737 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918017738 dimerization interface [polypeptide binding]; other site 205918017739 putative DNA binding site [nucleotide binding]; other site 205918017740 putative Zn2+ binding site [ion binding]; other site 205918017741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017742 putative substrate translocation pore; other site 205918017743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918017744 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017748 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017749 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017750 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017751 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017752 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017753 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017754 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017755 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017756 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205918017757 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 205918017758 FMN binding site [chemical binding]; other site 205918017759 active site 205918017760 substrate binding site [chemical binding]; other site 205918017761 catalytic residue [active] 205918017762 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918017763 1 probable transmembrane helix predicted by TMHMM2.0 205918017764 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918017765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017766 NAD(P) binding site [chemical binding]; other site 205918017767 active site 205918017768 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 205918017769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918017770 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918017771 dimerization interface [polypeptide binding]; other site 205918017772 Lysine efflux permease [General function prediction only]; Region: COG1279 205918017773 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017774 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017775 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017776 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017777 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017778 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017779 superoxide dismutase; Provisional; Region: PRK10543 205918017780 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 205918017781 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 205918017782 biofilm formation regulator HmsP; Provisional; Region: PRK11829 205918017783 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918017784 metal binding site [ion binding]; metal-binding site 205918017785 active site 205918017786 I-site; other site 205918017787 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918017788 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017789 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017790 Imelysin; Region: Peptidase_M75; cl09159 205918017791 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 205918017792 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 205918017793 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 205918017794 Imelysin; Region: Peptidase_M75; cl09159 205918017795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 205918017796 1 probable transmembrane helix predicted by TMHMM2.0 205918017797 1 probable transmembrane helix predicted by TMHMM2.0 205918017798 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 205918017799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918017800 S-adenosylmethionine binding site [chemical binding]; other site 205918017801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918017802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017803 dimer interface [polypeptide binding]; other site 205918017804 phosphorylation site [posttranslational modification] 205918017805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017806 ATP binding site [chemical binding]; other site 205918017807 Mg2+ binding site [ion binding]; other site 205918017808 G-X-G motif; other site 205918017809 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017810 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918017812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017813 active site 205918017814 phosphorylation site [posttranslational modification] 205918017815 intermolecular recognition site; other site 205918017816 dimerization interface [polypeptide binding]; other site 205918017817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918017818 DNA binding site [nucleotide binding] 205918017819 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 205918017820 active site 205918017821 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017822 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017823 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017824 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017825 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017826 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017827 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 205918017828 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 205918017829 ring oligomerisation interface [polypeptide binding]; other site 205918017830 ATP/Mg binding site [chemical binding]; other site 205918017831 stacking interactions; other site 205918017832 hinge regions; other site 205918017833 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 205918017834 oligomerisation interface [polypeptide binding]; other site 205918017835 mobile loop; other site 205918017836 roof hairpin; other site 205918017837 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 205918017838 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017839 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017840 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017841 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 205918017842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017843 NAD(P) binding site [chemical binding]; other site 205918017844 active site 205918017845 Protein of unknown function, DUF481; Region: DUF481; pfam04338 205918017846 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 205918017847 DNA binding site [nucleotide binding] 205918017848 active site 205918017849 muropeptide transporter; Validated; Region: ampG; cl17669 205918017850 muropeptide transporter; Validated; Region: ampG; cl17669 205918017851 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017852 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017853 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017854 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017855 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017856 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017857 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017858 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017859 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017860 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017861 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017862 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017863 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017864 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017865 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017866 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017867 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 205918017869 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 205918017870 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 205918017871 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 205918017872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 205918017873 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 205918017874 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 205918017875 1 probable transmembrane helix predicted by TMHMM2.0 205918017876 PAAR motif; Region: PAAR_motif; pfam05488 205918017877 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 205918017878 1 probable transmembrane helix predicted by TMHMM2.0 205918017879 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205918017880 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918017881 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017882 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017883 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 205918017885 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 205918017886 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 205918017887 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 205918017888 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 205918017889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918017890 dimerization interface [polypeptide binding]; other site 205918017891 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918017892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918017893 putative active site [active] 205918017894 heme pocket [chemical binding]; other site 205918017895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017896 dimer interface [polypeptide binding]; other site 205918017897 phosphorylation site [posttranslational modification] 205918017898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017899 ATP binding site [chemical binding]; other site 205918017900 Mg2+ binding site [ion binding]; other site 205918017901 G-X-G motif; other site 205918017902 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017903 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017904 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 205918017905 hypothetical protein; Provisional; Region: PRK08999 205918017906 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 205918017907 active site 205918017908 8-oxo-dGMP binding site [chemical binding]; other site 205918017909 nudix motif; other site 205918017910 metal binding site [ion binding]; metal-binding site 205918017911 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 205918017912 thiamine phosphate binding site [chemical binding]; other site 205918017913 active site 205918017914 pyrophosphate binding site [ion binding]; other site 205918017915 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 205918017916 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918017917 putative C-terminal domain interface [polypeptide binding]; other site 205918017918 putative GSH binding site (G-site) [chemical binding]; other site 205918017919 putative dimer interface [polypeptide binding]; other site 205918017920 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 205918017921 putative substrate binding pocket (H-site) [chemical binding]; other site 205918017922 putative N-terminal domain interface [polypeptide binding]; other site 205918017923 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 205918017924 heterotetramer interface [polypeptide binding]; other site 205918017925 active site pocket [active] 205918017926 cleavage site 205918017927 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 205918017928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 205918017929 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 205918017930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 205918017931 nucleotide binding region [chemical binding]; other site 205918017932 ATP-binding site [chemical binding]; other site 205918017933 SEC-C motif; Region: SEC-C; pfam02810 205918017934 Protein of unknown function (DUF721); Region: DUF721; pfam05258 205918017935 Protein of unknown function (DUF721); Region: DUF721; cl02324 205918017936 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 205918017937 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 205918017938 cell division protein FtsZ; Validated; Region: PRK09330 205918017939 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 205918017940 nucleotide binding site [chemical binding]; other site 205918017941 SulA interaction site; other site 205918017942 cell division protein FtsA; Region: ftsA; TIGR01174 205918017943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205918017944 nucleotide binding site [chemical binding]; other site 205918017945 Cell division protein FtsA; Region: FtsA; pfam14450 205918017946 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 205918017947 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 205918017948 Cell division protein FtsQ; Region: FtsQ; pfam03799 205918017949 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 205918017950 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 205918017951 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205918017952 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 205918017953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918017954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017956 1 probable transmembrane helix predicted by TMHMM2.0 205918017957 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 205918017958 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 205918017959 active site 205918017960 homodimer interface [polypeptide binding]; other site 205918017961 cell division protein FtsW; Region: ftsW; TIGR02614 205918017962 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017963 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017964 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017965 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017966 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017967 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017968 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017969 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017970 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017971 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 205918017972 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017973 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017974 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 205918017975 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 205918017976 Mg++ binding site [ion binding]; other site 205918017977 putative catalytic motif [active] 205918017978 putative substrate binding site [chemical binding]; other site 205918017979 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017980 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017981 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017982 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017983 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017984 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017985 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017986 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017987 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017988 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017989 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918017990 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 205918017991 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017992 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017993 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 205918017994 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918017995 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017996 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017997 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 205918017998 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205918017999 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 205918018000 1 probable transmembrane helix predicted by TMHMM2.0 205918018001 Cell division protein FtsL; Region: FtsL; pfam04999 205918018002 1 probable transmembrane helix predicted by TMHMM2.0 205918018003 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 205918018004 MraW methylase family; Region: Methyltransf_5; cl17771 205918018005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 205918018006 MraZ protein; Region: MraZ; pfam02381 205918018007 MraZ protein; Region: MraZ; pfam02381 205918018008 Predicted methyltransferases [General function prediction only]; Region: COG0313 205918018009 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 205918018010 putative SAM binding site [chemical binding]; other site 205918018011 putative homodimer interface [polypeptide binding]; other site 205918018012 LppC putative lipoprotein; Region: LppC; pfam04348 205918018013 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 205918018014 putative ligand binding site [chemical binding]; other site 205918018015 hypothetical protein; Reviewed; Region: PRK12497 205918018016 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 205918018017 dimer interface [polypeptide binding]; other site 205918018018 active site 205918018019 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 205918018020 BON domain; Region: BON; pfam04972 205918018021 BON domain; Region: BON; pfam04972 205918018022 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 205918018023 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 205918018024 stringent starvation protein A; Provisional; Region: sspA; PRK09481 205918018025 C-terminal domain interface [polypeptide binding]; other site 205918018026 putative GSH binding site (G-site) [chemical binding]; other site 205918018027 dimer interface [polypeptide binding]; other site 205918018028 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 205918018029 dimer interface [polypeptide binding]; other site 205918018030 N-terminal domain interface [polypeptide binding]; other site 205918018031 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 205918018032 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 205918018033 23S rRNA interface [nucleotide binding]; other site 205918018034 L3 interface [polypeptide binding]; other site 205918018035 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918018036 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 205918018037 conserved cys residue [active] 205918018038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918018039 Predicted ATPase [General function prediction only]; Region: COG1485 205918018040 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 205918018041 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 205918018042 active site 205918018043 HIGH motif; other site 205918018044 dimer interface [polypeptide binding]; other site 205918018045 KMSKS motif; other site 205918018046 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205918018047 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 205918018048 1 probable transmembrane helix predicted by TMHMM2.0 205918018049 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 205918018050 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 205918018051 CysD dimerization site [polypeptide binding]; other site 205918018052 G1 box; other site 205918018053 putative GEF interaction site [polypeptide binding]; other site 205918018054 GTP/Mg2+ binding site [chemical binding]; other site 205918018055 Switch I region; other site 205918018056 G2 box; other site 205918018057 G3 box; other site 205918018058 Switch II region; other site 205918018059 G4 box; other site 205918018060 G5 box; other site 205918018061 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 205918018062 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 205918018063 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 205918018064 ligand-binding site [chemical binding]; other site 205918018065 hypothetical protein; Reviewed; Region: PRK12275 205918018066 four helix bundle protein; Region: TIGR02436 205918018067 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 205918018068 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 205918018069 Active Sites [active] 205918018070 Uncharacterized conserved protein [Function unknown]; Region: COG0327 205918018071 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 205918018072 serine endoprotease; Provisional; Region: PRK10898 205918018073 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 205918018074 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205918018075 protein binding site [polypeptide binding]; other site 205918018076 1 probable transmembrane helix predicted by TMHMM2.0 205918018077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 205918018078 Transposase; Region: DEDD_Tnp_IS110; pfam01548 205918018079 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 205918018080 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 205918018081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918018082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918018083 homodimer interface [polypeptide binding]; other site 205918018084 catalytic residue [active] 205918018085 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 205918018086 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 205918018087 NAD binding site [chemical binding]; other site 205918018088 dimerization interface [polypeptide binding]; other site 205918018089 product binding site; other site 205918018090 substrate binding site [chemical binding]; other site 205918018091 zinc binding site [ion binding]; other site 205918018092 catalytic residues [active] 205918018093 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 205918018094 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 205918018095 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 205918018096 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 205918018097 hinge; other site 205918018098 active site 205918018099 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 205918018100 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918018101 anti sigma factor interaction site; other site 205918018102 regulatory phosphorylation site [posttranslational modification]; other site 205918018103 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 205918018104 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 205918018105 mce related protein; Region: MCE; pfam02470 205918018106 1 probable transmembrane helix predicted by TMHMM2.0 205918018107 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 205918018108 Permease; Region: Permease; cl00510 205918018109 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018110 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018111 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018112 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018113 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018114 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 205918018115 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 205918018116 Walker A/P-loop; other site 205918018117 ATP binding site [chemical binding]; other site 205918018118 Q-loop/lid; other site 205918018119 ABC transporter signature motif; other site 205918018120 Walker B; other site 205918018121 D-loop; other site 205918018122 H-loop/switch region; other site 205918018123 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 205918018124 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 205918018125 putative active site [active] 205918018126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 205918018127 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 205918018128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918018129 active site 205918018130 motif I; other site 205918018131 motif II; other site 205918018132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 205918018133 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 205918018134 1 probable transmembrane helix predicted by TMHMM2.0 205918018135 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 205918018136 OstA-like protein; Region: OstA; pfam03968 205918018137 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 205918018138 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 205918018139 Walker A/P-loop; other site 205918018140 ATP binding site [chemical binding]; other site 205918018141 Q-loop/lid; other site 205918018142 ABC transporter signature motif; other site 205918018143 Walker B; other site 205918018144 D-loop; other site 205918018145 H-loop/switch region; other site 205918018146 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 205918018147 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 205918018148 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 205918018149 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 205918018150 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 205918018151 30S subunit binding site; other site 205918018152 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 205918018153 active site 205918018154 phosphorylation site [posttranslational modification] 205918018155 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 205918018156 AAA domain; Region: AAA_18; pfam13238 205918018157 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 205918018158 dimerization domain swap beta strand [polypeptide binding]; other site 205918018159 regulatory protein interface [polypeptide binding]; other site 205918018160 active site 205918018161 regulatory phosphorylation site [posttranslational modification]; other site 205918018162 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 205918018163 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 205918018164 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 205918018165 Ebola nucleoprotein; Region: Ebola_NP; pfam05505 205918018166 peptidase PmbA; Provisional; Region: PRK11040 205918018167 hypothetical protein; Provisional; Region: PRK05255 205918018168 protease TldD; Provisional; Region: tldD; PRK10735 205918018169 nitrilase; Region: PLN02798 205918018170 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 205918018171 putative active site [active] 205918018172 catalytic triad [active] 205918018173 dimer interface [polypeptide binding]; other site 205918018174 TIGR02099 family protein; Region: TIGR02099 205918018175 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 205918018176 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018177 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018178 ribonuclease G; Provisional; Region: PRK11712 205918018179 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 205918018180 homodimer interface [polypeptide binding]; other site 205918018181 oligonucleotide binding site [chemical binding]; other site 205918018182 Maf-like protein; Region: Maf; pfam02545 205918018183 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205918018184 active site 205918018185 dimer interface [polypeptide binding]; other site 205918018186 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 205918018187 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018188 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018189 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018190 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018191 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018192 rod shape-determining protein MreC; Provisional; Region: PRK13922 205918018193 rod shape-determining protein MreC; Region: MreC; pfam04085 205918018194 rod shape-determining protein MreB; Provisional; Region: PRK13927 205918018195 MreB and similar proteins; Region: MreB_like; cd10225 205918018196 nucleotide binding site [chemical binding]; other site 205918018197 Mg binding site [ion binding]; other site 205918018198 putative protofilament interaction site [polypeptide binding]; other site 205918018199 RodZ interaction site [polypeptide binding]; other site 205918018200 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 205918018201 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918018202 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 205918018203 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 205918018204 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 205918018205 GatB domain; Region: GatB_Yqey; smart00845 205918018206 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 205918018207 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 205918018208 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 205918018209 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 205918018210 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 205918018211 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 205918018212 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018213 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018214 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018215 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018216 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018217 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018218 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018219 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018220 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018221 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018222 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018223 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 205918018224 Predicted permeases [General function prediction only]; Region: COG0679 205918018225 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018226 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018227 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018228 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018229 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018230 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018231 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018232 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018233 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018234 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 205918018235 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 205918018236 putative active site [active] 205918018237 putative metal binding site [ion binding]; other site 205918018238 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918018239 1 probable transmembrane helix predicted by TMHMM2.0 205918018240 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 205918018241 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 205918018242 putative RNA binding site [nucleotide binding]; other site 205918018243 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918018244 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918018245 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918018246 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 205918018247 ligand binding site [chemical binding]; other site 205918018248 1 probable transmembrane helix predicted by TMHMM2.0 205918018249 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 205918018250 1 probable transmembrane helix predicted by TMHMM2.0 205918018251 BON domain; Region: BON; pfam04972 205918018252 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 205918018253 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 205918018254 RNase E interface [polypeptide binding]; other site 205918018255 trimer interface [polypeptide binding]; other site 205918018256 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 205918018257 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 205918018258 RNase E interface [polypeptide binding]; other site 205918018259 trimer interface [polypeptide binding]; other site 205918018260 active site 205918018261 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 205918018262 putative nucleic acid binding region [nucleotide binding]; other site 205918018263 G-X-X-G motif; other site 205918018264 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 205918018265 RNA binding site [nucleotide binding]; other site 205918018266 domain interface; other site 205918018267 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 205918018268 16S/18S rRNA binding site [nucleotide binding]; other site 205918018269 S13e-L30e interaction site [polypeptide binding]; other site 205918018270 25S rRNA binding site [nucleotide binding]; other site 205918018271 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 205918018272 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 205918018273 RNA binding site [nucleotide binding]; other site 205918018274 active site 205918018275 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 205918018276 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 205918018277 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205918018278 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 205918018279 translation initiation factor IF-2; Region: IF-2; TIGR00487 205918018280 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205918018281 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 205918018282 G1 box; other site 205918018283 putative GEF interaction site [polypeptide binding]; other site 205918018284 GTP/Mg2+ binding site [chemical binding]; other site 205918018285 Switch I region; other site 205918018286 G2 box; other site 205918018287 G3 box; other site 205918018288 Switch II region; other site 205918018289 G4 box; other site 205918018290 G5 box; other site 205918018291 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 205918018292 Translation-initiation factor 2; Region: IF-2; pfam11987 205918018293 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 205918018294 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 205918018295 NusA N-terminal domain; Region: NusA_N; pfam08529 205918018296 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 205918018297 RNA binding site [nucleotide binding]; other site 205918018298 homodimer interface [polypeptide binding]; other site 205918018299 NusA-like KH domain; Region: KH_5; pfam13184 205918018300 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 205918018301 G-X-X-G motif; other site 205918018302 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 205918018303 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 205918018304 ribosome maturation protein RimP; Reviewed; Region: PRK00092 205918018305 Sm and related proteins; Region: Sm_like; cl00259 205918018306 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 205918018307 putative oligomer interface [polypeptide binding]; other site 205918018308 putative RNA binding site [nucleotide binding]; other site 205918018309 Preprotein translocase SecG subunit; Region: SecG; pfam03840 205918018310 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018311 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018312 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 205918018313 triosephosphate isomerase; Provisional; Region: PRK14567 205918018314 substrate binding site [chemical binding]; other site 205918018315 dimer interface [polypeptide binding]; other site 205918018316 catalytic triad [active] 205918018317 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 205918018318 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 205918018319 active site 205918018320 substrate binding site [chemical binding]; other site 205918018321 metal binding site [ion binding]; metal-binding site 205918018322 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 205918018323 dihydropteroate synthase; Region: DHPS; TIGR01496 205918018324 substrate binding pocket [chemical binding]; other site 205918018325 dimer interface [polypeptide binding]; other site 205918018326 inhibitor binding site; inhibition site 205918018327 FtsH Extracellular; Region: FtsH_ext; pfam06480 205918018328 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 205918018329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918018330 Walker A motif; other site 205918018331 ATP binding site [chemical binding]; other site 205918018332 Walker B motif; other site 205918018333 arginine finger; other site 205918018334 Peptidase family M41; Region: Peptidase_M41; pfam01434 205918018335 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018336 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018337 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 205918018338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918018339 S-adenosylmethionine binding site [chemical binding]; other site 205918018340 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 205918018341 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 205918018342 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 205918018343 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918018344 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 205918018345 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918018346 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 205918018347 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 205918018348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918018349 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205918018350 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 205918018351 IMP binding site; other site 205918018352 dimer interface [polypeptide binding]; other site 205918018353 interdomain contacts; other site 205918018354 partial ornithine binding site; other site 205918018355 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 205918018356 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 205918018357 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 205918018358 catalytic site [active] 205918018359 subunit interface [polypeptide binding]; other site 205918018360 dihydrodipicolinate reductase; Provisional; Region: PRK00048 205918018361 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 205918018362 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 205918018363 chaperone protein DnaJ; Provisional; Region: PRK10767 205918018364 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918018365 HSP70 interaction site [polypeptide binding]; other site 205918018366 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 205918018367 substrate binding site [polypeptide binding]; other site 205918018368 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 205918018369 Zn binding sites [ion binding]; other site 205918018370 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205918018371 dimer interface [polypeptide binding]; other site 205918018372 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205918018373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205918018374 nucleotide binding site [chemical binding]; other site 205918018375 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 205918018376 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 205918018377 dimer interface [polypeptide binding]; other site 205918018378 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 205918018379 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 205918018380 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 205918018381 Walker A/P-loop; other site 205918018382 ATP binding site [chemical binding]; other site 205918018383 Q-loop/lid; other site 205918018384 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 205918018385 ABC transporter signature motif; other site 205918018386 Walker B; other site 205918018387 D-loop; other site 205918018388 H-loop/switch region; other site 205918018389 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 205918018390 metal binding site 2 [ion binding]; metal-binding site 205918018391 putative DNA binding helix; other site 205918018392 metal binding site 1 [ion binding]; metal-binding site 205918018393 dimer interface [polypeptide binding]; other site 205918018394 structural Zn2+ binding site [ion binding]; other site 205918018395 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 205918018396 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 205918018397 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 205918018398 1 probable transmembrane helix predicted by TMHMM2.0 205918018399 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 205918018400 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 205918018401 putative coenzyme Q binding site [chemical binding]; other site 205918018402 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 205918018403 Na2 binding site [ion binding]; other site 205918018404 putative substrate binding site 1 [chemical binding]; other site 205918018405 Na binding site 1 [ion binding]; other site 205918018406 putative substrate binding site 2 [chemical binding]; other site 205918018407 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018408 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018409 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018410 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018411 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018412 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018413 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018414 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018415 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018416 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018417 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018418 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 205918018419 SmpB-tmRNA interface; other site 205918018420 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 205918018421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918018422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918018423 metal binding site [ion binding]; metal-binding site 205918018424 active site 205918018425 I-site; other site 205918018426 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018427 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018428 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018429 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018430 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018431 putative acetyltransferase; Provisional; Region: PRK03624 205918018432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918018433 Coenzyme A binding pocket [chemical binding]; other site 205918018434 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 205918018435 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 205918018436 dimer interface [polypeptide binding]; other site 205918018437 active site 205918018438 heme binding site [chemical binding]; other site 205918018439 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 205918018440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918018441 PAS fold; Region: PAS_3; pfam08447 205918018442 putative active site [active] 205918018443 heme pocket [chemical binding]; other site 205918018444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918018445 PAS fold; Region: PAS_3; pfam08447 205918018446 putative active site [active] 205918018447 heme pocket [chemical binding]; other site 205918018448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918018449 putative CheW interface [polypeptide binding]; other site 205918018450 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 205918018451 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018452 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018453 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018454 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018455 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018456 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018457 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018458 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018459 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018460 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018461 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018462 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918018463 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 205918018464 1 probable transmembrane helix predicted by TMHMM2.0 205918018465 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918018466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918018467 Walker A/P-loop; other site 205918018468 ATP binding site [chemical binding]; other site 205918018469 Q-loop/lid; other site 205918018470 ABC transporter signature motif; other site 205918018471 Walker B; other site 205918018472 D-loop; other site 205918018473 H-loop/switch region; other site 205918018474 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 205918018475 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918018476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918018477 Walker A/P-loop; other site 205918018478 ATP binding site [chemical binding]; other site 205918018479 Q-loop/lid; other site 205918018480 ABC transporter signature motif; other site 205918018481 Walker B; other site 205918018482 D-loop; other site 205918018483 H-loop/switch region; other site 205918018484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918018485 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918018486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018487 dimer interface [polypeptide binding]; other site 205918018488 conserved gate region; other site 205918018489 putative PBP binding loops; other site 205918018490 ABC-ATPase subunit interface; other site 205918018491 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018492 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018493 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018494 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018495 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018496 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018497 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918018498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018499 dimer interface [polypeptide binding]; other site 205918018500 conserved gate region; other site 205918018501 putative PBP binding loops; other site 205918018502 ABC-ATPase subunit interface; other site 205918018503 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018504 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018505 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018506 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018507 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018508 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018509 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 205918018510 Autoinducer binding domain; Region: Autoind_bind; pfam03472 205918018511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918018512 DNA binding residues [nucleotide binding] 205918018513 dimerization interface [polypeptide binding]; other site 205918018514 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 205918018515 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918018516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918018517 dimerization interface [polypeptide binding]; other site 205918018518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918018519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918018520 dimer interface [polypeptide binding]; other site 205918018521 putative CheW interface [polypeptide binding]; other site 205918018522 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018523 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018524 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 205918018525 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918018526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918018527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918018528 Coenzyme A binding pocket [chemical binding]; other site 205918018529 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918018530 GAF domain; Region: GAF; pfam01590 205918018531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918018532 metal binding site [ion binding]; metal-binding site 205918018533 active site 205918018534 I-site; other site 205918018535 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918018536 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205918018537 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018538 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018539 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018540 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018541 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018542 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018543 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018544 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018545 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018546 galactarate dehydratase; Region: galactar-dH20; TIGR03248 205918018547 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 205918018548 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 205918018549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918018550 D-galactonate transporter; Region: 2A0114; TIGR00893 205918018551 putative substrate translocation pore; other site 205918018552 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018553 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018554 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018555 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018556 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018557 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018558 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018559 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018560 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018561 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018562 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018563 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 205918018564 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 205918018565 putative active site [active] 205918018566 catalytic residue [active] 205918018567 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918018568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918018569 DNA-binding site [nucleotide binding]; DNA binding site 205918018570 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 205918018571 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 205918018572 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 205918018573 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 205918018574 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018575 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018576 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018577 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018578 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018579 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 205918018580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918018581 active site 205918018582 phosphorylation site [posttranslational modification] 205918018583 intermolecular recognition site; other site 205918018584 dimerization interface [polypeptide binding]; other site 205918018585 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918018586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918018587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 205918018588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918018589 ATP binding site [chemical binding]; other site 205918018590 G-X-G motif; other site 205918018591 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018592 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018593 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018594 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018595 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018596 Protein of unknown function (DUF541); Region: SIMPL; cl01077 205918018597 Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217 205918018598 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918018599 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918018600 peptide binding site [polypeptide binding]; other site 205918018601 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918018602 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918018603 peptide binding site [polypeptide binding]; other site 205918018604 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918018605 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918018606 peptide binding site [polypeptide binding]; other site 205918018607 outer membrane porin, OprD family; Region: OprD; pfam03573 205918018608 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205918018609 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918018610 peptide binding site [polypeptide binding]; other site 205918018611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918018612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018613 dimer interface [polypeptide binding]; other site 205918018614 conserved gate region; other site 205918018615 putative PBP binding loops; other site 205918018616 ABC-ATPase subunit interface; other site 205918018617 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018618 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018619 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018620 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018621 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018622 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018623 dipeptide transporter; Provisional; Region: PRK10913 205918018624 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 205918018625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018626 putative PBP binding loops; other site 205918018627 dimer interface [polypeptide binding]; other site 205918018628 ABC-ATPase subunit interface; other site 205918018629 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018630 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018631 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018632 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018633 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018634 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018635 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918018636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918018637 Walker A/P-loop; other site 205918018638 ATP binding site [chemical binding]; other site 205918018639 Q-loop/lid; other site 205918018640 ABC transporter signature motif; other site 205918018641 Walker B; other site 205918018642 D-loop; other site 205918018643 H-loop/switch region; other site 205918018644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918018645 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918018646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205918018647 Walker A/P-loop; other site 205918018648 ATP binding site [chemical binding]; other site 205918018649 Q-loop/lid; other site 205918018650 ABC transporter signature motif; other site 205918018651 Walker B; other site 205918018652 D-loop; other site 205918018653 H-loop/switch region; other site 205918018654 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 205918018655 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918018656 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 205918018657 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 205918018658 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 205918018659 Flavodoxin; Region: Flavodoxin_1; pfam00258 205918018660 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 205918018661 FAD binding pocket [chemical binding]; other site 205918018662 FAD binding motif [chemical binding]; other site 205918018663 catalytic residues [active] 205918018664 NAD binding pocket [chemical binding]; other site 205918018665 phosphate binding motif [ion binding]; other site 205918018666 beta-alpha-beta structure motif; other site 205918018667 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018668 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018669 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018670 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018671 transferase, transferring glycosyl groups; Region: PLN02939 205918018672 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 205918018673 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 205918018674 dimer interface [polypeptide binding]; other site 205918018675 active site 205918018676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918018677 catalytic residues [active] 205918018678 substrate binding site [chemical binding]; other site 205918018679 Peptidase M60-like family; Region: M60-like; pfam13402 205918018680 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 205918018681 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 205918018682 Walker A/P-loop; other site 205918018683 ATP binding site [chemical binding]; other site 205918018684 Q-loop/lid; other site 205918018685 ABC transporter signature motif; other site 205918018686 Walker B; other site 205918018687 D-loop; other site 205918018688 H-loop/switch region; other site 205918018689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 205918018690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018691 dimer interface [polypeptide binding]; other site 205918018692 conserved gate region; other site 205918018693 ABC-ATPase subunit interface; other site 205918018694 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018695 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018696 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018697 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018698 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018699 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018700 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918018701 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 205918018702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018703 ABC-ATPase subunit interface; other site 205918018704 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018705 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018706 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018707 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018708 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018709 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 205918018710 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 205918018711 G1 box; other site 205918018712 putative GEF interaction site [polypeptide binding]; other site 205918018713 GTP/Mg2+ binding site [chemical binding]; other site 205918018714 Switch I region; other site 205918018715 G2 box; other site 205918018716 G3 box; other site 205918018717 Switch II region; other site 205918018718 G4 box; other site 205918018719 G5 box; other site 205918018720 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 205918018721 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 205918018722 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 205918018723 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205918018724 hypothetical protein; Provisional; Region: PRK05208 205918018725 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018726 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018727 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018728 AAA domain; Region: AAA_32; pfam13654 205918018729 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205918018730 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 205918018731 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 205918018732 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 205918018733 transcription elongation factor regulatory protein; Validated; Region: PRK06342 205918018734 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918018735 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 205918018736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918018737 Walker A/P-loop; other site 205918018738 ATP binding site [chemical binding]; other site 205918018739 Q-loop/lid; other site 205918018740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918018741 ABC transporter signature motif; other site 205918018742 Walker B; other site 205918018743 D-loop; other site 205918018744 ABC transporter; Region: ABC_tran_2; pfam12848 205918018745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205918018746 PAS domain S-box; Region: sensory_box; TIGR00229 205918018747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918018748 putative active site [active] 205918018749 heme pocket [chemical binding]; other site 205918018750 PAS domain S-box; Region: sensory_box; TIGR00229 205918018751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918018752 putative active site [active] 205918018753 heme pocket [chemical binding]; other site 205918018754 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918018755 PAS domain; Region: PAS_9; pfam13426 205918018756 putative active site [active] 205918018757 heme pocket [chemical binding]; other site 205918018758 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918018759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918018760 metal binding site [ion binding]; metal-binding site 205918018761 active site 205918018762 I-site; other site 205918018763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918018764 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018765 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918018767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918018768 dimerization interface [polypeptide binding]; other site 205918018769 DNA binding residues [nucleotide binding] 205918018770 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 205918018771 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918018772 Amidase; Region: Amidase; cl11426 205918018773 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 205918018774 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 205918018775 dimer interface [polypeptide binding]; other site 205918018776 active site 205918018777 glycine-pyridoxal phosphate binding site [chemical binding]; other site 205918018778 folate binding site [chemical binding]; other site 205918018779 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 205918018780 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 205918018781 P-loop, Walker A motif; other site 205918018782 Base recognition motif; other site 205918018783 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 205918018784 Uncharacterized small protein [Function unknown]; Region: COG2879 205918018785 carbon starvation protein A; Provisional; Region: PRK15015 205918018786 Carbon starvation protein CstA; Region: CstA; pfam02554 205918018787 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 205918018788 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018789 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018790 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018791 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018792 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018793 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018794 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018795 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018796 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018797 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018798 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018799 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018800 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018801 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018802 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018803 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018804 PilZ domain; Region: PilZ; pfam07238 205918018805 DNA repair protein RadA; Provisional; Region: PRK11823 205918018806 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 205918018807 Walker A motif/ATP binding site; other site 205918018808 ATP binding site [chemical binding]; other site 205918018809 Walker B motif; other site 205918018810 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 205918018811 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 205918018812 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 205918018813 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018814 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018815 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 205918018816 ferredoxin-NADP reductase; Provisional; Region: PRK10926 205918018817 FAD binding pocket [chemical binding]; other site 205918018818 FAD binding motif [chemical binding]; other site 205918018819 phosphate binding motif [ion binding]; other site 205918018820 beta-alpha-beta structure motif; other site 205918018821 NAD binding pocket [chemical binding]; other site 205918018822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918018823 DNA binding residues [nucleotide binding] 205918018824 dimerization interface [polypeptide binding]; other site 205918018825 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 205918018826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918018827 S-adenosylmethionine binding site [chemical binding]; other site 205918018828 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 205918018829 1 probable transmembrane helix predicted by TMHMM2.0 205918018830 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 205918018831 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 205918018832 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 205918018833 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018834 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018835 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018836 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018837 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018838 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018839 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018840 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018841 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 205918018842 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018843 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018844 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018845 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018846 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018847 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018848 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018849 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018850 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018851 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 205918018852 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 205918018853 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 205918018854 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 205918018855 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 205918018856 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 205918018857 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 205918018858 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 205918018859 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018860 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018861 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018862 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018863 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018864 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018865 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018866 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018867 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018868 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018869 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018870 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 205918018871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918018872 S-adenosylmethionine binding site [chemical binding]; other site 205918018873 enterobactin exporter EntS; Provisional; Region: PRK10489 205918018874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918018875 putative substrate translocation pore; other site 205918018876 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018877 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018878 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018879 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018880 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018881 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018882 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018883 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018884 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018885 Predicted metalloprotease [General function prediction only]; Region: COG2321 205918018886 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 205918018887 1 probable transmembrane helix predicted by TMHMM2.0 205918018888 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 205918018889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918018890 active site 205918018891 motif I; other site 205918018892 motif II; other site 205918018893 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 205918018894 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 205918018895 active site 205918018896 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 205918018897 catalytic triad [active] 205918018898 dimer interface [polypeptide binding]; other site 205918018899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918018900 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918018901 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 205918018902 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 205918018903 putative active site [active] 205918018904 Zn binding site [ion binding]; other site 205918018905 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 205918018906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918018907 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 205918018908 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918018909 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918018910 ATP binding site [chemical binding]; other site 205918018911 Mg++ binding site [ion binding]; other site 205918018912 motif III; other site 205918018913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918018914 nucleotide binding region [chemical binding]; other site 205918018915 ATP-binding site [chemical binding]; other site 205918018916 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 205918018917 EamA-like transporter family; Region: EamA; pfam00892 205918018918 EamA-like transporter family; Region: EamA; pfam00892 205918018919 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018920 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018921 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018922 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018923 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018924 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018925 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018926 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018927 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018928 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018929 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918018930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918018931 putative DNA binding site [nucleotide binding]; other site 205918018932 putative Zn2+ binding site [ion binding]; other site 205918018933 AsnC family; Region: AsnC_trans_reg; pfam01037 205918018934 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 205918018935 active site 205918018936 catalytic site [active] 205918018937 substrate binding site [chemical binding]; other site 205918018938 Uncharacterized conserved protein [Function unknown]; Region: COG1432 205918018939 LabA_like proteins; Region: LabA; cd10911 205918018940 putative metal binding site [ion binding]; other site 205918018941 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 205918018942 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 205918018943 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018944 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018945 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018946 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018947 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018948 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018949 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205918018950 putative catalytic site [active] 205918018951 putative metal binding site [ion binding]; other site 205918018952 putative phosphate binding site [ion binding]; other site 205918018953 1 probable transmembrane helix predicted by TMHMM2.0 205918018954 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 205918018955 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 205918018956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 205918018957 AAA domain; Region: AAA_33; pfam13671 205918018958 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205918018959 ATP-binding site [chemical binding]; other site 205918018960 Gluconate-6-phosphate binding site [chemical binding]; other site 205918018961 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918018962 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018963 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018964 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018965 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018966 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018967 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 205918018968 active site 205918018969 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918018970 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 205918018971 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 205918018972 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918018973 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 205918018974 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918018975 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 205918018976 putative NADP binding site [chemical binding]; other site 205918018977 active site 205918018978 Methyltransferase domain; Region: Methyltransf_12; pfam08242 205918018979 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918018980 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018981 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018982 active site 205918018983 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 205918018984 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918018985 KR domain; Region: KR; pfam08659 205918018986 putative NADP binding site [chemical binding]; other site 205918018987 active site 205918018988 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918018989 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018990 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018991 active site 205918018992 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 205918018993 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018994 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018995 active site 205918018996 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 205918018997 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018998 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 205918018999 active site 205918019000 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918019001 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 205918019002 putative NADP binding site [chemical binding]; other site 205918019003 active site 205918019004 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 205918019005 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918019006 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918019007 active site 205918019008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918019009 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918019010 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918019011 active site 205918019012 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 205918019013 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 205918019014 active site 205918019015 dimer interface [polypeptide binding]; other site 205918019016 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 205918019017 Ligand Binding Site [chemical binding]; other site 205918019018 Molecular Tunnel; other site 205918019019 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 205918019020 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918019021 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918019022 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 205918019023 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918019024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918019025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918019026 dimerization interface [polypeptide binding]; other site 205918019027 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 205918019028 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 205918019029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918019030 ATP binding site [chemical binding]; other site 205918019031 putative Mg++ binding site [ion binding]; other site 205918019032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918019033 nucleotide binding region [chemical binding]; other site 205918019034 ATP-binding site [chemical binding]; other site 205918019035 Helicase associated domain (HA2); Region: HA2; pfam04408 205918019036 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 205918019037 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 205918019038 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205918019039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918019040 catalytic residue [active] 205918019041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918019042 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019043 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019044 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019045 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019046 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019047 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019048 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019049 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019050 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019051 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019052 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019053 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019054 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 205918019055 serine O-acetyltransferase; Region: cysE; TIGR01172 205918019056 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 205918019057 trimer interface [polypeptide binding]; other site 205918019058 active site 205918019059 substrate binding site [chemical binding]; other site 205918019060 CoA binding site [chemical binding]; other site 205918019061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918019062 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918019063 DNA-binding site [nucleotide binding]; DNA binding site 205918019064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918019065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918019066 homodimer interface [polypeptide binding]; other site 205918019067 catalytic residue [active] 205918019068 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 205918019069 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918019070 HSP70 interaction site [polypeptide binding]; other site 205918019071 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918019072 homotrimer interaction site [polypeptide binding]; other site 205918019073 putative active site [active] 205918019074 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 205918019075 Family of unknown function (DUF633); Region: DUF633; pfam04816 205918019076 Thioredoxin; Region: Thioredoxin_4; cl17273 205918019077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 205918019078 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205918019079 substrate binding pocket [chemical binding]; other site 205918019080 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918019081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205918019082 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 205918019083 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 205918019084 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019085 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019086 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 205918019087 Cation efflux family; Region: Cation_efflux; cl00316 205918019088 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019089 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019090 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019091 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019092 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019093 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019094 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918019095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918019096 putative DNA binding site [nucleotide binding]; other site 205918019097 putative Zn2+ binding site [ion binding]; other site 205918019098 AsnC family; Region: AsnC_trans_reg; pfam01037 205918019099 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 205918019100 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205918019101 active site 205918019102 AMP nucleosidase; Provisional; Region: PRK08292 205918019103 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 205918019104 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 205918019105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918019106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918019107 active site 205918019108 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 205918019109 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 205918019110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918019111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918019112 dimer interface [polypeptide binding]; other site 205918019113 phosphorylation site [posttranslational modification] 205918019114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918019115 ATP binding site [chemical binding]; other site 205918019116 Mg2+ binding site [ion binding]; other site 205918019117 G-X-G motif; other site 205918019118 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019119 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019120 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019121 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019122 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019123 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019124 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019125 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 205918019126 dimer interface [polypeptide binding]; other site 205918019127 substrate binding site [chemical binding]; other site 205918019128 ATP binding site [chemical binding]; other site 205918019129 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 205918019130 thiamine phosphate binding site [chemical binding]; other site 205918019131 active site 205918019132 pyrophosphate binding site [ion binding]; other site 205918019133 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 205918019134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918019135 inhibitor-cofactor binding pocket; inhibition site 205918019136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918019137 catalytic residue [active] 205918019138 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918019139 Sel1-like repeats; Region: SEL1; smart00671 205918019140 Sel1-like repeats; Region: SEL1; smart00671 205918019141 1 probable transmembrane helix predicted by TMHMM2.0 205918019142 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 205918019143 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 205918019144 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205918019145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918019146 FeS/SAM binding site; other site 205918019147 TRAM domain; Region: TRAM; pfam01938 205918019148 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 205918019149 PhoH-like protein; Region: PhoH; pfam02562 205918019150 metal-binding heat shock protein; Provisional; Region: PRK00016 205918019151 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 205918019152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918019153 Transporter associated domain; Region: CorC_HlyC; smart01091 205918019154 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 205918019155 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 205918019156 putative active site [active] 205918019157 catalytic triad [active] 205918019158 putative dimer interface [polypeptide binding]; other site 205918019159 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019160 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019161 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019162 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019163 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019164 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019165 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019166 Uncharacterized conserved protein [Function unknown]; Region: COG1434 205918019167 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 205918019168 putative active site [active] 205918019169 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019170 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019171 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 205918019172 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 205918019173 HIGH motif; other site 205918019174 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205918019175 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918019176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918019177 active site 205918019178 KMSKS motif; other site 205918019179 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 205918019180 tRNA binding surface [nucleotide binding]; other site 205918019181 Lipopolysaccharide-assembly; Region: LptE; cl01125 205918019182 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 205918019183 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 205918019184 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019185 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019186 Domain of unknown function; Region: DUF331; cl01149 205918019187 Transglycosylase SLT domain; Region: SLT_2; pfam13406 205918019188 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918019189 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918019190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 205918019191 lipoyl synthase; Provisional; Region: PRK05481 205918019192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918019193 FeS/SAM binding site; other site 205918019194 lipoate-protein ligase B; Provisional; Region: PRK14342 205918019195 hypothetical protein; Provisional; Region: PRK00341 205918019196 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 205918019197 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 205918019198 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 205918019199 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 205918019200 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 205918019201 Sporulation related domain; Region: SPOR; pfam05036 205918019202 Transglycosylase SLT domain; Region: SLT_2; pfam13406 205918019203 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205918019204 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918019205 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 205918019206 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019207 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019208 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019209 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019210 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019211 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019212 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019213 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019214 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019215 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019216 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 205918019217 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205918019218 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 205918019219 1 probable transmembrane helix predicted by TMHMM2.0 205918019220 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 205918019221 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 205918019222 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 205918019223 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 205918019224 active site 205918019225 (T/H)XGH motif; other site 205918019226 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 205918019227 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 205918019228 putative catalytic cysteine [active] 205918019229 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 205918019230 active site 205918019231 DNA binding site [nucleotide binding] 205918019232 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205918019233 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 205918019234 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 205918019235 active site 205918019236 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 205918019237 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019238 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019239 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019240 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019241 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019242 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019243 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019244 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019245 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019246 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019247 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019248 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019249 Predicted membrane protein [Function unknown]; Region: COG4655 205918019250 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 205918019251 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019252 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019254 putative active site [active] 205918019255 heme pocket [chemical binding]; other site 205918019256 PAS fold; Region: PAS_3; pfam08447 205918019257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019258 putative active site [active] 205918019259 heme pocket [chemical binding]; other site 205918019260 PAS domain; Region: PAS; smart00091 205918019261 PAS fold; Region: PAS_4; pfam08448 205918019262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918019263 dimer interface [polypeptide binding]; other site 205918019264 phosphorylation site [posttranslational modification] 205918019265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918019266 ATP binding site [chemical binding]; other site 205918019267 Mg2+ binding site [ion binding]; other site 205918019268 G-X-G motif; other site 205918019269 1 probable transmembrane helix predicted by TMHMM2.0 205918019270 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019271 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019272 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019273 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918019275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019276 active site 205918019277 phosphorylation site [posttranslational modification] 205918019278 intermolecular recognition site; other site 205918019279 dimerization interface [polypeptide binding]; other site 205918019280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918019281 DNA binding residues [nucleotide binding] 205918019282 dimerization interface [polypeptide binding]; other site 205918019283 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 205918019284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 205918019285 active site 205918019286 phosphorylation site [posttranslational modification] 205918019287 intermolecular recognition site; other site 205918019288 dimerization interface [polypeptide binding]; other site 205918019289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019290 active site 205918019291 phosphorylation site [posttranslational modification] 205918019292 intermolecular recognition site; other site 205918019293 dimerization interface [polypeptide binding]; other site 205918019294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918019295 metal binding site [ion binding]; metal-binding site 205918019296 active site 205918019297 I-site; other site 205918019298 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 205918019299 1 probable transmembrane helix predicted by TMHMM2.0 205918019300 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 205918019301 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 205918019302 nudix motif; other site 205918019303 translation initiation factor Sui1; Validated; Region: PRK06824 205918019304 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 205918019305 putative rRNA binding site [nucleotide binding]; other site 205918019306 arginine decarboxylase; Provisional; Region: PRK05354 205918019307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 205918019308 dimer interface [polypeptide binding]; other site 205918019309 active site 205918019310 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918019311 catalytic residues [active] 205918019312 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 205918019313 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 205918019314 FecR protein; Region: FecR; pfam04773 205918019315 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205918019316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918019317 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 205918019318 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 205918019319 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019320 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019321 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019322 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019323 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019324 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019325 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019326 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019327 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019328 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019329 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 205918019330 MG2 domain; Region: A2M_N; pfam01835 205918019331 Alpha-2-macroglobulin family; Region: A2M; pfam00207 205918019332 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 205918019333 surface patch; other site 205918019334 thioester region; other site 205918019335 specificity defining residues; other site 205918019336 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019337 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019338 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019339 penicillin-binding protein 1C; Provisional; Region: PRK11240 205918019340 Transglycosylase; Region: Transgly; pfam00912 205918019341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 205918019342 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 205918019343 1 probable transmembrane helix predicted by TMHMM2.0 205918019344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019345 active site 205918019346 phosphorylation site [posttranslational modification] 205918019347 intermolecular recognition site; other site 205918019348 dimerization interface [polypeptide binding]; other site 205918019349 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 205918019350 1 probable transmembrane helix predicted by TMHMM2.0 205918019351 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 205918019352 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 205918019353 1 probable transmembrane helix predicted by TMHMM2.0 205918019354 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 205918019355 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 205918019356 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918019357 1 probable transmembrane helix predicted by TMHMM2.0 205918019358 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 205918019359 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 205918019360 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 205918019361 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 205918019362 ATP binding site [chemical binding]; other site 205918019363 Walker A motif; other site 205918019364 hexamer interface [polypeptide binding]; other site 205918019365 Walker B motif; other site 205918019366 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 205918019367 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918019368 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019369 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019370 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019371 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019372 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 205918019373 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205918019374 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019375 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019376 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019377 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019378 TPR repeat; Region: TPR_11; pfam13414 205918019379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918019380 binding surface 205918019381 TPR motif; other site 205918019382 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 205918019383 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 205918019384 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 205918019385 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 205918019386 DsbD alpha interface [polypeptide binding]; other site 205918019387 catalytic residues [active] 205918019388 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019389 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019390 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019391 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019392 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019393 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019394 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019395 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019396 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 205918019397 Dehydroquinase class II; Region: DHquinase_II; pfam01220 205918019398 trimer interface [polypeptide binding]; other site 205918019399 active site 205918019400 dimer interface [polypeptide binding]; other site 205918019401 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 205918019402 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918019403 carboxyltransferase (CT) interaction site; other site 205918019404 biotinylation site [posttranslational modification]; other site 205918019405 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 205918019406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918019407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 205918019408 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 205918019409 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 205918019410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918019411 S-adenosylmethionine binding site [chemical binding]; other site 205918019412 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 205918019413 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 205918019414 1 probable transmembrane helix predicted by TMHMM2.0 205918019415 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 205918019416 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205918019417 FMN binding site [chemical binding]; other site 205918019418 active site 205918019419 catalytic residues [active] 205918019420 substrate binding site [chemical binding]; other site 205918019421 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 205918019422 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 205918019423 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 205918019424 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 205918019425 purine monophosphate binding site [chemical binding]; other site 205918019426 dimer interface [polypeptide binding]; other site 205918019427 putative catalytic residues [active] 205918019428 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 205918019429 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 205918019430 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 205918019431 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 205918019432 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 205918019433 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 205918019434 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 205918019435 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 205918019436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918019437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918019438 dimer interface [polypeptide binding]; other site 205918019439 phosphorylation site [posttranslational modification] 205918019440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918019441 ATP binding site [chemical binding]; other site 205918019442 Mg2+ binding site [ion binding]; other site 205918019443 G-X-G motif; other site 205918019444 Response regulator receiver domain; Region: Response_reg; pfam00072 205918019445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019446 active site 205918019447 phosphorylation site [posttranslational modification] 205918019448 intermolecular recognition site; other site 205918019449 dimerization interface [polypeptide binding]; other site 205918019450 Response regulator receiver domain; Region: Response_reg; pfam00072 205918019451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019452 active site 205918019453 phosphorylation site [posttranslational modification] 205918019454 intermolecular recognition site; other site 205918019455 dimerization interface [polypeptide binding]; other site 205918019456 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019457 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019458 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019459 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019460 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019461 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019462 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019463 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019464 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 205918019465 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019466 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019467 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019468 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019469 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019470 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019471 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 205918019472 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 205918019473 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 205918019474 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 205918019475 active site 205918019476 SAM binding site [chemical binding]; other site 205918019477 homodimer interface [polypeptide binding]; other site 205918019478 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 205918019479 active site 205918019480 SAM binding site [chemical binding]; other site 205918019481 homodimer interface [polypeptide binding]; other site 205918019482 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 205918019483 Precorrin-8X methylmutase; Region: CbiC; pfam02570 205918019484 precorrin-3B synthase; Region: CobG; TIGR02435 205918019485 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918019486 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918019487 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 205918019488 active site 205918019489 putative homodimer interface [polypeptide binding]; other site 205918019490 SAM binding site [chemical binding]; other site 205918019491 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 205918019492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918019493 S-adenosylmethionine binding site [chemical binding]; other site 205918019494 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 205918019495 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 205918019496 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 205918019497 Transposase IS200 like; Region: Y1_Tnp; pfam01797 205918019498 Protein of unknown function (DUF461); Region: DUF461; pfam04314 205918019499 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 205918019500 1 probable transmembrane helix predicted by TMHMM2.0 205918019501 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918019502 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 205918019503 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 205918019504 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 205918019505 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019506 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019507 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019508 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019509 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019510 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 205918019511 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 205918019512 putative ligand binding site [chemical binding]; other site 205918019513 HEAT repeats; Region: HEAT_2; pfam13646 205918019514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918019515 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205918019516 TM-ABC transporter signature motif; other site 205918019517 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019518 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019519 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019520 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019521 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019522 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019523 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019524 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918019525 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 205918019526 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918019527 TM-ABC transporter signature motif; other site 205918019528 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019529 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019530 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019531 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019532 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019533 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019534 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019535 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019536 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918019537 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 205918019538 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 205918019539 Walker A/P-loop; other site 205918019540 ATP binding site [chemical binding]; other site 205918019541 Q-loop/lid; other site 205918019542 ABC transporter signature motif; other site 205918019543 Walker B; other site 205918019544 D-loop; other site 205918019545 H-loop/switch region; other site 205918019546 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 205918019547 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 205918019548 Walker A/P-loop; other site 205918019549 ATP binding site [chemical binding]; other site 205918019550 Q-loop/lid; other site 205918019551 ABC transporter signature motif; other site 205918019552 Walker B; other site 205918019553 D-loop; other site 205918019554 H-loop/switch region; other site 205918019555 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 205918019556 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 205918019557 alpha-gamma subunit interface [polypeptide binding]; other site 205918019558 beta-gamma subunit interface [polypeptide binding]; other site 205918019559 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918019560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918019561 Coenzyme A binding pocket [chemical binding]; other site 205918019562 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918019563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918019564 Coenzyme A binding pocket [chemical binding]; other site 205918019565 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 205918019566 gamma-beta subunit interface [polypeptide binding]; other site 205918019567 alpha-beta subunit interface [polypeptide binding]; other site 205918019568 urease subunit alpha; Reviewed; Region: ureC; PRK13207 205918019569 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 205918019570 subunit interactions [polypeptide binding]; other site 205918019571 active site 205918019572 flap region; other site 205918019573 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205918019574 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918019575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918019576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918019577 dimer interface [polypeptide binding]; other site 205918019578 phosphorylation site [posttranslational modification] 205918019579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918019580 ATP binding site [chemical binding]; other site 205918019581 Mg2+ binding site [ion binding]; other site 205918019582 G-X-G motif; other site 205918019583 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 205918019584 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918019585 HSP70 interaction site [polypeptide binding]; other site 205918019586 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205918019587 substrate binding site [polypeptide binding]; other site 205918019588 dimer interface [polypeptide binding]; other site 205918019589 putative chaperone; Provisional; Region: PRK11678 205918019590 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 205918019591 nucleotide binding site [chemical binding]; other site 205918019592 putative NEF/HSP70 interaction site [polypeptide binding]; other site 205918019593 SBD interface [polypeptide binding]; other site 205918019594 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 205918019595 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019596 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019597 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019598 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019599 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019600 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019601 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019602 psiF repeat; Region: PsiF_repeat; pfam07769 205918019603 psiF repeat; Region: PsiF_repeat; pfam07769 205918019604 EamA-like transporter family; Region: EamA; pfam00892 205918019605 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918019606 EamA-like transporter family; Region: EamA; pfam00892 205918019607 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019608 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019609 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019610 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019611 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019612 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019613 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019614 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019615 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019616 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019617 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 205918019618 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 205918019619 Ferritin-like domain; Region: Ferritin; pfam00210 205918019620 dinuclear metal binding motif [ion binding]; other site 205918019621 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 205918019622 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 205918019623 1 probable transmembrane helix predicted by TMHMM2.0 205918019624 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 205918019625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918019626 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 205918019627 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 205918019628 dimer interface [polypeptide binding]; other site 205918019629 catalytic residues [active] 205918019630 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 205918019631 UreF; Region: UreF; pfam01730 205918019632 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205918019633 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 205918019634 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019635 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019636 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019637 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019638 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019639 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019640 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019641 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019642 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019643 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019644 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019645 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 205918019646 dimerization interface [polypeptide binding]; other site 205918019647 active site 205918019648 thiamine monophosphate kinase; Provisional; Region: PRK05731 205918019649 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 205918019650 ATP binding site [chemical binding]; other site 205918019651 dimerization interface [polypeptide binding]; other site 205918019652 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 205918019653 putative RNA binding site [nucleotide binding]; other site 205918019654 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 205918019655 homopentamer interface [polypeptide binding]; other site 205918019656 active site 205918019657 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 205918019658 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 205918019659 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 205918019660 dimerization interface [polypeptide binding]; other site 205918019661 active site 205918019662 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 205918019663 Lumazine binding domain; Region: Lum_binding; pfam00677 205918019664 Lumazine binding domain; Region: Lum_binding; pfam00677 205918019665 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 205918019666 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 205918019667 catalytic motif [active] 205918019668 Zn binding site [ion binding]; other site 205918019669 RibD C-terminal domain; Region: RibD_C; cl17279 205918019670 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 205918019671 ATP cone domain; Region: ATP-cone; pfam03477 205918019672 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 205918019673 Predicted methyltransferase [General function prediction only]; Region: COG3897 205918019674 Putative methyltransferase; Region: Methyltransf_16; pfam10294 205918019675 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 205918019676 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 205918019677 SnoaL-like domain; Region: SnoaL_2; pfam12680 205918019678 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 205918019679 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205918019680 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205918019681 Walker A/P-loop; other site 205918019682 ATP binding site [chemical binding]; other site 205918019683 Q-loop/lid; other site 205918019684 ABC transporter signature motif; other site 205918019685 Walker B; other site 205918019686 D-loop; other site 205918019687 H-loop/switch region; other site 205918019688 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918019689 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 205918019690 FtsX-like permease family; Region: FtsX; pfam02687 205918019691 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019692 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019693 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019694 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019695 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 205918019696 OmpW family; Region: OmpW; cl17427 205918019697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918019698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918019699 NAD(P) binding site [chemical binding]; other site 205918019700 active site 205918019701 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 205918019702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918019703 NAD(P) binding site [chemical binding]; other site 205918019704 active site 205918019705 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205918019706 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918019707 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019708 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019709 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019710 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019711 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019712 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019713 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019714 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019715 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019716 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019717 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918019718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 205918019719 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918019720 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918019721 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 205918019722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 205918019723 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918019724 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918019725 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 205918019726 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019727 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019728 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019729 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918019730 TolR protein; Region: tolR; TIGR02801 205918019731 1 probable transmembrane helix predicted by TMHMM2.0 205918019732 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 205918019733 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918019734 N-terminal plug; other site 205918019735 ligand-binding site [chemical binding]; other site 205918019736 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918019737 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 205918019738 substrate binding site [chemical binding]; other site 205918019739 dimer interface [polypeptide binding]; other site 205918019740 ATP binding site [chemical binding]; other site 205918019741 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 205918019742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918019743 putative substrate translocation pore; other site 205918019744 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019748 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019749 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019750 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019751 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019752 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019753 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019754 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019755 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019756 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 205918019757 active site 205918019758 catalytic residues [active] 205918019759 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 205918019760 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 205918019761 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 205918019762 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 205918019763 intersubunit interface [polypeptide binding]; other site 205918019764 active site 205918019765 catalytic residue [active] 205918019766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019767 PAS domain; Region: PAS_9; pfam13426 205918019768 putative active site [active] 205918019769 heme pocket [chemical binding]; other site 205918019770 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918019771 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918019772 metal binding site [ion binding]; metal-binding site 205918019773 active site 205918019774 I-site; other site 205918019775 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918019776 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019777 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019778 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 205918019779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918019780 substrate binding pocket [chemical binding]; other site 205918019781 membrane-bound complex binding site; other site 205918019782 hinge residues; other site 205918019783 Beta-lactamase; Region: Beta-lactamase; pfam00144 205918019784 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918019785 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918019786 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 205918019787 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 205918019788 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019789 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019790 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019791 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 205918019792 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 205918019793 1 probable transmembrane helix predicted by TMHMM2.0 205918019794 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918019795 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918019796 N-terminal plug; other site 205918019797 ligand-binding site [chemical binding]; other site 205918019798 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 205918019799 catalytic core [active] 205918019800 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 205918019801 1 probable transmembrane helix predicted by TMHMM2.0 205918019802 MarR family; Region: MarR_2; pfam12802 205918019803 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205918019804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205918019805 nucleotide binding site [chemical binding]; other site 205918019806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205918019807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918019808 1 probable transmembrane helix predicted by TMHMM2.0 205918019809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918019810 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019811 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019812 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019813 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019814 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019815 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019816 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918019817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019818 dimer interface [polypeptide binding]; other site 205918019819 conserved gate region; other site 205918019820 putative PBP binding loops; other site 205918019821 ABC-ATPase subunit interface; other site 205918019822 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019823 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019824 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019825 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019826 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019827 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019828 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918019829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918019830 Walker A/P-loop; other site 205918019831 ATP binding site [chemical binding]; other site 205918019832 Q-loop/lid; other site 205918019833 ABC transporter signature motif; other site 205918019834 Walker B; other site 205918019835 D-loop; other site 205918019836 H-loop/switch region; other site 205918019837 TOBE domain; Region: TOBE_2; pfam08402 205918019838 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 205918019839 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 205918019840 putative active site [active] 205918019841 catalytic site [active] 205918019842 putative metal binding site [ion binding]; other site 205918019843 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 205918019844 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 205918019845 active site 205918019846 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 205918019847 Domain of unknown function (DUF955); Region: DUF955; pfam06114 205918019848 Beta protein; Region: Beta_protein; pfam14350 205918019849 SEC-C motif; Region: SEC-C; pfam02810 205918019850 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205918019851 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205918019852 dimer interface [polypeptide binding]; other site 205918019853 ssDNA binding site [nucleotide binding]; other site 205918019854 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205918019855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918019856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918019857 putative substrate translocation pore; other site 205918019858 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019859 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019860 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019861 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019862 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019863 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019864 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019865 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019866 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019867 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019868 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019869 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019870 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 205918019871 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 205918019872 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 205918019873 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 205918019874 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 205918019875 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 205918019876 heme binding site [chemical binding]; other site 205918019877 ferroxidase pore; other site 205918019878 ferroxidase diiron center [ion binding]; other site 205918019879 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 205918019880 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 205918019881 tetramer interface [polypeptide binding]; other site 205918019882 heme binding pocket [chemical binding]; other site 205918019883 NADPH binding site [chemical binding]; other site 205918019884 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 205918019885 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 205918019886 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 205918019887 alphaNTD homodimer interface [polypeptide binding]; other site 205918019888 alphaNTD - beta interaction site [polypeptide binding]; other site 205918019889 alphaNTD - beta' interaction site [polypeptide binding]; other site 205918019890 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 205918019891 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 205918019892 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 205918019893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918019894 RNA binding surface [nucleotide binding]; other site 205918019895 30S ribosomal protein S11; Validated; Region: PRK05309 205918019896 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 205918019897 30S ribosomal protein S13; Region: bact_S13; TIGR03631 205918019898 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 205918019899 SecY translocase; Region: SecY; pfam00344 205918019900 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019901 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019902 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019903 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019904 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019905 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019906 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019907 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019908 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019909 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019910 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 205918019911 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 205918019912 23S rRNA binding site [nucleotide binding]; other site 205918019913 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 205918019914 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 205918019915 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 205918019916 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 205918019917 5S rRNA interface [nucleotide binding]; other site 205918019918 23S rRNA interface [nucleotide binding]; other site 205918019919 L5 interface [polypeptide binding]; other site 205918019920 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 205918019921 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205918019922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205918019923 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 205918019924 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 205918019925 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 205918019926 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 205918019927 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 205918019928 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 205918019929 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 205918019930 RNA binding site [nucleotide binding]; other site 205918019931 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 205918019932 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 205918019933 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 205918019934 23S rRNA interface [nucleotide binding]; other site 205918019935 putative translocon interaction site; other site 205918019936 signal recognition particle (SRP54) interaction site; other site 205918019937 L23 interface [polypeptide binding]; other site 205918019938 trigger factor interaction site; other site 205918019939 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 205918019940 23S rRNA interface [nucleotide binding]; other site 205918019941 5S rRNA interface [nucleotide binding]; other site 205918019942 putative antibiotic binding site [chemical binding]; other site 205918019943 L25 interface [polypeptide binding]; other site 205918019944 L27 interface [polypeptide binding]; other site 205918019945 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 205918019946 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 205918019947 G-X-X-G motif; other site 205918019948 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 205918019949 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 205918019950 protein-rRNA interface [nucleotide binding]; other site 205918019951 putative translocon binding site; other site 205918019952 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 205918019953 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 205918019954 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 205918019955 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 205918019956 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 205918019957 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 205918019958 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 205918019959 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 205918019960 elongation factor Tu; Reviewed; Region: PRK00049 205918019961 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 205918019962 G1 box; other site 205918019963 GEF interaction site [polypeptide binding]; other site 205918019964 GTP/Mg2+ binding site [chemical binding]; other site 205918019965 Switch I region; other site 205918019966 G2 box; other site 205918019967 G3 box; other site 205918019968 Switch II region; other site 205918019969 G4 box; other site 205918019970 G5 box; other site 205918019971 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 205918019972 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 205918019973 Antibiotic Binding Site [chemical binding]; other site 205918019974 elongation factor G; Reviewed; Region: PRK00007 205918019975 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 205918019976 G1 box; other site 205918019977 putative GEF interaction site [polypeptide binding]; other site 205918019978 GTP/Mg2+ binding site [chemical binding]; other site 205918019979 Switch I region; other site 205918019980 G2 box; other site 205918019981 G3 box; other site 205918019982 Switch II region; other site 205918019983 G4 box; other site 205918019984 G5 box; other site 205918019985 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 205918019986 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 205918019987 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 205918019988 30S ribosomal protein S7; Validated; Region: PRK05302 205918019989 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 205918019990 S17 interaction site [polypeptide binding]; other site 205918019991 S8 interaction site; other site 205918019992 16S rRNA interaction site [nucleotide binding]; other site 205918019993 streptomycin interaction site [chemical binding]; other site 205918019994 23S rRNA interaction site [nucleotide binding]; other site 205918019995 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 205918019996 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 205918019997 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 205918019998 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 205918019999 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 205918020000 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 205918020001 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 205918020002 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205918020003 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 205918020004 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205918020005 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 205918020006 DNA binding site [nucleotide binding] 205918020007 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 205918020008 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 205918020009 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 205918020010 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 205918020011 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205918020012 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 205918020013 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205918020014 RPB3 interaction site [polypeptide binding]; other site 205918020015 RPB1 interaction site [polypeptide binding]; other site 205918020016 RPB11 interaction site [polypeptide binding]; other site 205918020017 RPB10 interaction site [polypeptide binding]; other site 205918020018 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 205918020019 peripheral dimer interface [polypeptide binding]; other site 205918020020 core dimer interface [polypeptide binding]; other site 205918020021 L10 interface [polypeptide binding]; other site 205918020022 L11 interface [polypeptide binding]; other site 205918020023 putative EF-Tu interaction site [polypeptide binding]; other site 205918020024 putative EF-G interaction site [polypeptide binding]; other site 205918020025 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 205918020026 23S rRNA interface [nucleotide binding]; other site 205918020027 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 205918020028 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 205918020029 mRNA/rRNA interface [nucleotide binding]; other site 205918020030 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 205918020031 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 205918020032 23S rRNA interface [nucleotide binding]; other site 205918020033 L7/L12 interface [polypeptide binding]; other site 205918020034 putative thiostrepton binding site; other site 205918020035 L25 interface [polypeptide binding]; other site 205918020036 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 205918020037 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 205918020038 putative homodimer interface [polypeptide binding]; other site 205918020039 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 205918020040 heterodimer interface [polypeptide binding]; other site 205918020041 homodimer interface [polypeptide binding]; other site 205918020042 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 205918020043 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020044 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020045 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020046 pantothenate kinase; Reviewed; Region: PRK13322 205918020047 Biotin operon repressor [Transcription]; Region: BirA; COG1654 205918020048 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 205918020049 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 205918020050 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 205918020051 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 205918020052 active site 205918020053 HIGH motif; other site 205918020054 dimer interface [polypeptide binding]; other site 205918020055 KMSKS motif; other site 205918020056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 205918020057 RNA binding surface [nucleotide binding]; other site 205918020058 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 205918020059 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918020060 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 205918020061 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 205918020062 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 205918020063 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205918020064 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 205918020065 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020066 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020067 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020068 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020069 Protein of unknown function (DUF805); Region: DUF805; pfam05656 205918020070 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020071 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020072 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020073 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020074 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 205918020075 classical (c) SDRs; Region: SDR_c; cd05233 205918020076 NAD(P) binding site [chemical binding]; other site 205918020077 active site 205918020078 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 205918020079 nucleotide binding site/active site [active] 205918020080 HIT family signature motif; other site 205918020081 catalytic residue [active] 205918020082 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 205918020083 diiron binding motif [ion binding]; other site 205918020084 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 205918020085 OsmC-like protein; Region: OsmC; cl00767 205918020086 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 205918020087 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918020088 ligand binding site [chemical binding]; other site 205918020089 flexible hinge region; other site 205918020090 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205918020091 putative switch regulator; other site 205918020092 non-specific DNA interactions [nucleotide binding]; other site 205918020093 DNA binding site [nucleotide binding] 205918020094 sequence specific DNA binding site [nucleotide binding]; other site 205918020095 putative cAMP binding site [chemical binding]; other site 205918020096 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 205918020097 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 205918020098 active site 205918020099 ribulose/triose binding site [chemical binding]; other site 205918020100 phosphate binding site [ion binding]; other site 205918020101 substrate (anthranilate) binding pocket [chemical binding]; other site 205918020102 product (indole) binding pocket [chemical binding]; other site 205918020103 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 205918020104 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 205918020105 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 205918020106 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 205918020107 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 205918020108 glutamine binding [chemical binding]; other site 205918020109 catalytic triad [active] 205918020110 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 205918020111 Predicted chitinase [General function prediction only]; Region: COG3179 205918020112 catalytic residue [active] 205918020113 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 205918020114 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 205918020115 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 205918020116 Phage protein GP46; Region: GP46; pfam07409 205918020117 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 205918020118 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 205918020119 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 205918020120 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 205918020121 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 205918020122 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 205918020123 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020124 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020125 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 205918020126 Phage tail tube protein; Region: Tail_tube; pfam10618 205918020127 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 205918020128 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 205918020129 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 205918020130 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 205918020131 1 probable transmembrane helix predicted by TMHMM2.0 205918020132 1 probable transmembrane helix predicted by TMHMM2.0 205918020133 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 205918020134 Mu-like prophage protein Com; Region: Mu-like_Com; pfam10122 205918020135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918020136 non-specific DNA binding site [nucleotide binding]; other site 205918020137 salt bridge; other site 205918020138 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 205918020139 sequence-specific DNA binding site [nucleotide binding]; other site 205918020140 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918020141 Catalytic site [active] 205918020142 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 205918020143 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 205918020144 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 205918020145 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 205918020146 active site 205918020147 catalytic triad [active] 205918020148 oxyanion hole [active] 205918020149 Autotransporter beta-domain; Region: Autotransporter; pfam03797 205918020150 1 probable transmembrane helix predicted by TMHMM2.0 205918020151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918020152 Transposase; Region: HTH_Tnp_1; pfam01527 205918020153 putative transposase OrfB; Reviewed; Region: PHA02517 205918020154 HTH-like domain; Region: HTH_21; pfam13276 205918020155 Integrase core domain; Region: rve; pfam00665 205918020156 Integrase core domain; Region: rve_3; pfam13683 205918020157 anthranilate synthase component I; Provisional; Region: PRK13565 205918020158 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 205918020159 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 205918020160 phosphoglycolate phosphatase; Provisional; Region: PRK13223 205918020161 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 205918020162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918020163 motif II; other site 205918020164 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 205918020165 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 205918020166 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 205918020167 substrate binding site [chemical binding]; other site 205918020168 hexamer interface [polypeptide binding]; other site 205918020169 metal binding site [ion binding]; metal-binding site 205918020170 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918020171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020172 dimer interface [polypeptide binding]; other site 205918020173 conserved gate region; other site 205918020174 putative PBP binding loops; other site 205918020175 ABC-ATPase subunit interface; other site 205918020176 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020177 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020178 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020179 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020180 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020181 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020183 dimer interface [polypeptide binding]; other site 205918020184 conserved gate region; other site 205918020185 putative PBP binding loops; other site 205918020186 ABC-ATPase subunit interface; other site 205918020187 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020188 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020189 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020190 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020191 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020192 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020193 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918020194 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205918020195 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918020196 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 205918020197 Walker A/P-loop; other site 205918020198 ATP binding site [chemical binding]; other site 205918020199 Q-loop/lid; other site 205918020200 ABC transporter signature motif; other site 205918020201 Walker B; other site 205918020202 D-loop; other site 205918020203 H-loop/switch region; other site 205918020204 TOBE domain; Region: TOBE_2; pfam08402 205918020205 putative transposase OrfB; Reviewed; Region: PHA02517 205918020206 HTH-like domain; Region: HTH_21; pfam13276 205918020207 Integrase core domain; Region: rve; pfam00665 205918020208 Integrase core domain; Region: rve_2; pfam13333 205918020209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918020210 Helix-turn-helix domain; Region: HTH_28; pfam13518 205918020211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918020212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918020213 active site 205918020214 phosphorylation site [posttranslational modification] 205918020215 intermolecular recognition site; other site 205918020216 dimerization interface [polypeptide binding]; other site 205918020217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918020218 DNA binding residues [nucleotide binding] 205918020219 dimerization interface [polypeptide binding]; other site 205918020220 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918020221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918020222 substrate binding pocket [chemical binding]; other site 205918020223 membrane-bound complex binding site; other site 205918020224 hinge residues; other site 205918020225 PAS domain; Region: PAS_9; pfam13426 205918020226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020227 putative active site [active] 205918020228 heme pocket [chemical binding]; other site 205918020229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205918020230 Histidine kinase; Region: HisKA_3; pfam07730 205918020231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918020232 ATP binding site [chemical binding]; other site 205918020233 Mg2+ binding site [ion binding]; other site 205918020234 G-X-G motif; other site 205918020235 1 probable transmembrane helix predicted by TMHMM2.0 205918020236 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 205918020237 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 205918020238 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 205918020239 putative metal binding site [ion binding]; other site 205918020240 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918020241 HSP70 interaction site [polypeptide binding]; other site 205918020242 1 probable transmembrane helix predicted by TMHMM2.0 205918020243 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 205918020244 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 205918020245 Substrate binding site; other site 205918020246 metal-binding site 205918020247 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 205918020248 Phosphotransferase enzyme family; Region: APH; pfam01636 205918020249 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 205918020250 OstA-like protein; Region: OstA; cl00844 205918020251 Organic solvent tolerance protein; Region: OstA_C; pfam04453 205918020252 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 205918020253 SurA N-terminal domain; Region: SurA_N; pfam09312 205918020254 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 205918020255 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 205918020256 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 205918020257 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 205918020258 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 205918020259 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 205918020260 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 205918020261 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 205918020262 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 205918020263 active site 205918020264 metal binding site [ion binding]; metal-binding site 205918020265 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 205918020266 active site residue [active] 205918020267 PrkA family serine protein kinase; Provisional; Region: PRK15455 205918020268 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 205918020269 hypothetical protein; Provisional; Region: PRK05325 205918020270 SpoVR family protein; Provisional; Region: PRK11767 205918020271 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 205918020272 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 205918020273 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205918020274 active site 205918020275 NTP binding site [chemical binding]; other site 205918020276 metal binding triad [ion binding]; metal-binding site 205918020277 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205918020278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205918020279 Zn2+ binding site [ion binding]; other site 205918020280 Mg2+ binding site [ion binding]; other site 205918020281 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205918020282 catalytic center binding site [active] 205918020283 ATP binding site [chemical binding]; other site 205918020284 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 205918020285 homooctamer interface [polypeptide binding]; other site 205918020286 active site 205918020287 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 205918020288 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020289 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020290 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020291 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020292 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020293 UGMP family protein; Validated; Region: PRK09604 205918020294 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 205918020295 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 205918020296 DNA primase; Validated; Region: dnaG; PRK05667 205918020297 CHC2 zinc finger; Region: zf-CHC2; pfam01807 205918020298 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 205918020299 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 205918020300 active site 205918020301 metal binding site [ion binding]; metal-binding site 205918020302 interdomain interaction site; other site 205918020303 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 205918020304 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 205918020305 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 205918020306 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 205918020307 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205918020308 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 205918020309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918020310 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205918020311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918020312 DNA binding residues [nucleotide binding] 205918020313 1 probable transmembrane helix predicted by TMHMM2.0 205918020314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020315 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 205918020316 putative active site [active] 205918020317 heme pocket [chemical binding]; other site 205918020318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020319 putative active site [active] 205918020320 heme pocket [chemical binding]; other site 205918020321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020322 PAS domain; Region: PAS_9; pfam13426 205918020323 putative active site [active] 205918020324 heme pocket [chemical binding]; other site 205918020325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918020326 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918020327 metal binding site [ion binding]; metal-binding site 205918020328 active site 205918020329 I-site; other site 205918020330 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918020331 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 205918020332 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020333 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020334 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020335 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020336 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020337 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 205918020338 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 205918020339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918020340 active site 205918020341 DNA binding site [nucleotide binding] 205918020342 Int/Topo IB signature motif; other site 205918020343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918020344 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918020345 Coenzyme A binding pocket [chemical binding]; other site 205918020346 ISPpu14, transposase Orf3 205918020347 S-type Pyocin; Region: Pyocin_S; pfam06958 205918020348 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 205918020349 active site 205918020350 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 205918020351 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205918020352 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020353 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020354 hypothetical protein 205918020355 similar to Type II secretory pathway component ExeA (predicted ATPase) 205918020356 Pto-interacting domain of the HopAB family of Type III Effector proteins; Region: HopAB_PID; cd12802 205918020357 Pto binding site [polypeptide binding]; other site 205918020358 Kinase-interacting domains of the HopAB family of Type III Effector proteins; Region: HopAB_KID; cl17109 205918020359 kinase binding site [polypeptide binding]; other site 205918020360 AvrPtoB E3 ubiquitin ligase; Region: AvrPtoB-E3_ubiq; pfam09046 205918020361 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 205918020362 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020363 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020364 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020365 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020366 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020367 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020368 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 205918020369 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 205918020370 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918020371 acyl-activating enzyme (AAE) consensus motif; other site 205918020372 AMP binding site [chemical binding]; other site 205918020373 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 205918020374 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205918020375 putative trimer interface [polypeptide binding]; other site 205918020376 putative CoA binding site [chemical binding]; other site 205918020377 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205918020378 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205918020379 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020380 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020381 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020382 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020383 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020384 Fic family protein [Function unknown]; Region: COG3177 205918020385 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 205918020386 Fic/DOC family; Region: Fic; pfam02661 205918020387 Predicted membrane protein [Function unknown]; Region: COG1289 205918020388 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 205918020389 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020390 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020391 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020392 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020393 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020394 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020395 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918020396 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 205918020397 putative DNA binding site [nucleotide binding]; other site 205918020398 putative Zn2+ binding site [ion binding]; other site 205918020399 AsnC family; Region: AsnC_trans_reg; pfam01037 205918020400 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 205918020401 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918020402 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 205918020403 putative active site [active] 205918020404 catalytic triad [active] 205918020405 putative dimer interface [polypeptide binding]; other site 205918020406 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 205918020407 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918020408 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918020409 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918020410 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 205918020411 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 205918020412 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 205918020413 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 205918020414 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 205918020415 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 205918020416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918020417 FeS/SAM binding site; other site 205918020418 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 205918020419 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205918020420 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205918020421 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 205918020422 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020423 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020424 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 205918020425 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 205918020426 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918020427 active site 205918020428 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 205918020429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918020430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918020431 metal binding site [ion binding]; metal-binding site 205918020432 active site 205918020433 I-site; other site 205918020434 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020435 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020436 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020437 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020438 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020439 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020440 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918020442 Helix-turn-helix domain; Region: HTH_28; pfam13518 205918020443 putative transposase OrfB; Reviewed; Region: PHA02517 205918020444 HTH-like domain; Region: HTH_21; pfam13276 205918020445 Integrase core domain; Region: rve; pfam00665 205918020446 Integrase core domain; Region: rve_2; pfam13333 205918020447 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 205918020448 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 205918020449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918020450 active site 205918020451 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 205918020452 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 205918020453 AAA domain; Region: AAA_26; pfam13500 205918020454 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 205918020455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020456 S-adenosylmethionine binding site [chemical binding]; other site 205918020457 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 205918020458 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 205918020459 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 205918020460 substrate-cofactor binding pocket; other site 205918020461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020462 catalytic residue [active] 205918020463 biotin synthase; Provisional; Region: PRK15108 205918020464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918020465 FeS/SAM binding site; other site 205918020466 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 205918020467 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 205918020468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918020469 active site 205918020470 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 205918020471 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 205918020472 TOBE domain; Region: TOBE; cl01440 205918020473 TOBE domain; Region: TOBE; cl01440 205918020474 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 205918020475 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 205918020476 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918020477 active site 205918020478 metal binding site [ion binding]; metal-binding site 205918020479 hexamer interface [polypeptide binding]; other site 205918020480 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918020481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918020482 Walker A/P-loop; other site 205918020483 ATP binding site [chemical binding]; other site 205918020484 Q-loop/lid; other site 205918020485 ABC transporter signature motif; other site 205918020486 Walker B; other site 205918020487 D-loop; other site 205918020488 H-loop/switch region; other site 205918020489 TOBE domain; Region: TOBE_2; pfam08402 205918020490 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918020491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020492 dimer interface [polypeptide binding]; other site 205918020493 conserved gate region; other site 205918020494 putative PBP binding loops; other site 205918020495 ABC-ATPase subunit interface; other site 205918020496 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020497 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020498 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020499 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020500 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020501 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020502 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205918020503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020504 dimer interface [polypeptide binding]; other site 205918020505 conserved gate region; other site 205918020506 putative PBP binding loops; other site 205918020507 ABC-ATPase subunit interface; other site 205918020508 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020509 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020510 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020511 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020512 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020513 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020514 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205918020515 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918020516 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918020517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918020518 DNA binding site [nucleotide binding] 205918020519 domain linker motif; other site 205918020520 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 205918020521 putative dimerization interface [polypeptide binding]; other site 205918020522 putative ligand binding site [chemical binding]; other site 205918020523 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 205918020524 serine/threonine protein kinase; Provisional; Region: PRK11768 205918020525 Predicted permeases [General function prediction only]; Region: RarD; COG2962 205918020526 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020527 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020528 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020529 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020530 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020531 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020532 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020533 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020534 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020535 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918020536 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 205918020537 ACT domain; Region: ACT_6; pfam13740 205918020538 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 205918020539 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 205918020540 active site 205918020541 Response regulator receiver domain; Region: Response_reg; pfam00072 205918020542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918020543 active site 205918020544 phosphorylation site [posttranslational modification] 205918020545 intermolecular recognition site; other site 205918020546 dimerization interface [polypeptide binding]; other site 205918020547 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 205918020548 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918020549 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 205918020550 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 205918020551 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918020552 metal binding triad; other site 205918020553 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 205918020554 active site 205918020555 catalytic site [active] 205918020556 substrate binding site [chemical binding]; other site 205918020557 Cell division protein ZapA; Region: ZapA; pfam05164 205918020558 rod shape-determining protein MreC; Provisional; Region: PRK13922 205918020559 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918020560 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918020561 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918020562 dimer interface [polypeptide binding]; other site 205918020563 putative CheW interface [polypeptide binding]; other site 205918020564 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020565 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020566 Transposase IS200 like; Region: Y1_Tnp; pfam01797 205918020567 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918020568 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 205918020569 conserved cys residue [active] 205918020570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918020571 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 205918020572 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 205918020573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020574 dimer interface [polypeptide binding]; other site 205918020575 conserved gate region; other site 205918020576 putative PBP binding loops; other site 205918020577 ABC-ATPase subunit interface; other site 205918020578 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020579 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020580 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020581 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020582 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020583 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020584 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 205918020585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918020586 Walker A/P-loop; other site 205918020587 ATP binding site [chemical binding]; other site 205918020588 Q-loop/lid; other site 205918020589 ABC transporter signature motif; other site 205918020590 Walker B; other site 205918020591 D-loop; other site 205918020592 H-loop/switch region; other site 205918020593 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 205918020594 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 205918020595 dimer interface [polypeptide binding]; other site 205918020596 active site 205918020597 glycine-pyridoxal phosphate binding site [chemical binding]; other site 205918020598 folate binding site [chemical binding]; other site 205918020599 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 205918020600 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 205918020601 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 205918020602 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 205918020603 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 205918020604 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918020605 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 205918020606 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 205918020607 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 205918020608 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 205918020609 putative active site [active] 205918020610 putative substrate binding site [chemical binding]; other site 205918020611 putative cosubstrate binding site; other site 205918020612 catalytic site [active] 205918020613 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 205918020614 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 205918020615 NAD binding site [chemical binding]; other site 205918020616 catalytic Zn binding site [ion binding]; other site 205918020617 structural Zn binding site [ion binding]; other site 205918020618 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020619 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020620 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 205918020621 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020622 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918020623 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 205918020624 putative acyl-acceptor binding pocket; other site 205918020625 1 probable transmembrane helix predicted by TMHMM2.0 205918020626 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 205918020627 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918020628 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918020629 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918020630 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918020631 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918020632 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918020633 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918020634 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 205918020635 putative C-terminal domain interface [polypeptide binding]; other site 205918020636 putative GSH binding site (G-site) [chemical binding]; other site 205918020637 putative dimer interface [polypeptide binding]; other site 205918020638 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 205918020639 N-terminal domain interface [polypeptide binding]; other site 205918020640 dimer interface [polypeptide binding]; other site 205918020641 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020642 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020643 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918020644 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 205918020645 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 205918020646 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020647 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020648 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020649 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020650 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918020651 FecR protein; Region: FecR; pfam04773 205918020652 1 probable transmembrane helix predicted by TMHMM2.0 205918020653 RNA polymerase sigma factor; Reviewed; Region: PRK12523 205918020654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918020655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918020656 DNA binding residues [nucleotide binding] 205918020657 choline dehydrogenase; Validated; Region: PRK02106 205918020658 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 205918020659 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 205918020660 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205918020661 NAD(P) binding site [chemical binding]; other site 205918020662 catalytic residues [active] 205918020663 transcriptional regulator BetI; Validated; Region: PRK00767 205918020664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918020665 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 205918020666 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 205918020667 G1 box; other site 205918020668 GTP/Mg2+ binding site [chemical binding]; other site 205918020669 G2 box; other site 205918020670 Switch I region; other site 205918020671 G3 box; other site 205918020672 Switch II region; other site 205918020673 G4 box; other site 205918020674 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 205918020675 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 205918020676 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020677 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020678 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020679 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020680 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 205918020681 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 205918020682 folate binding site [chemical binding]; other site 205918020683 NADP+ binding site [chemical binding]; other site 205918020684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020685 S-adenosylmethionine binding site [chemical binding]; other site 205918020686 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 205918020687 ThiS interaction site; other site 205918020688 putative active site [active] 205918020689 tetramer interface [polypeptide binding]; other site 205918020690 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205918020691 thiS-thiF/thiG interaction site; other site 205918020692 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 205918020693 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020694 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020695 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020696 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020697 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 205918020698 Transglycosylase; Region: Transgly; cl17702 205918020699 1 probable transmembrane helix predicted by TMHMM2.0 205918020700 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 205918020701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918020702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918020703 DNA binding residues [nucleotide binding] 205918020704 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 205918020705 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 205918020706 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020707 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020708 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020709 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020710 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 205918020711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918020712 Walker A/P-loop; other site 205918020713 ATP binding site [chemical binding]; other site 205918020714 Q-loop/lid; other site 205918020715 ABC transporter signature motif; other site 205918020716 Walker B; other site 205918020717 D-loop; other site 205918020718 H-loop/switch region; other site 205918020719 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 205918020720 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 205918020721 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205918020722 P loop; other site 205918020723 GTP binding site [chemical binding]; other site 205918020724 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205918020725 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918020726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918020727 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205918020728 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918020729 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918020730 1 probable transmembrane helix predicted by TMHMM2.0 205918020731 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 205918020732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020733 S-adenosylmethionine binding site [chemical binding]; other site 205918020734 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 205918020735 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 205918020736 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 205918020737 active site residue [active] 205918020738 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 205918020739 active site residue [active] 205918020740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918020741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918020742 Bacterial transcriptional repressor; Region: TetR; pfam13972 205918020743 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 205918020744 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 205918020745 active site 205918020746 (T/H)XGH motif; other site 205918020747 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 205918020748 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020749 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020750 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 205918020751 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 205918020752 DNA binding site [nucleotide binding] 205918020753 catalytic residue [active] 205918020754 H2TH interface [polypeptide binding]; other site 205918020755 putative catalytic residues [active] 205918020756 turnover-facilitating residue; other site 205918020757 intercalation triad [nucleotide binding]; other site 205918020758 8OG recognition residue [nucleotide binding]; other site 205918020759 putative reading head residues; other site 205918020760 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 205918020761 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 205918020762 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 205918020763 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 205918020764 intracellular protease, PfpI family; Region: PfpI; TIGR01382 205918020765 proposed catalytic triad [active] 205918020766 conserved cys residue [active] 205918020767 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 205918020768 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 205918020769 putative RNA binding site [nucleotide binding]; other site 205918020770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020771 S-adenosylmethionine binding site [chemical binding]; other site 205918020772 TraX protein; Region: TraX; pfam05857 205918020773 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020774 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020775 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020776 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020777 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020778 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020779 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 205918020780 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 205918020781 tetramer interface [polypeptide binding]; other site 205918020782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020783 catalytic residue [active] 205918020784 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 205918020785 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 205918020786 putative transporter; Provisional; Region: PRK10504 205918020787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918020788 putative substrate translocation pore; other site 205918020789 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020790 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020791 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020792 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020793 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020794 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020795 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020796 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020797 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020798 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020799 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020800 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020801 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020802 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020803 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918020804 GAF domain; Region: GAF; pfam01590 205918020805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020806 PAS domain; Region: PAS_9; pfam13426 205918020807 putative active site [active] 205918020808 heme pocket [chemical binding]; other site 205918020809 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 205918020810 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918020811 metal binding site [ion binding]; metal-binding site 205918020812 active site 205918020813 I-site; other site 205918020814 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918020815 methionine sulfoxide reductase A; Provisional; Region: PRK00058 205918020816 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 205918020817 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 205918020818 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 205918020819 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 205918020820 FAD binding pocket [chemical binding]; other site 205918020821 FAD binding motif [chemical binding]; other site 205918020822 phosphate binding motif [ion binding]; other site 205918020823 beta-alpha-beta structure motif; other site 205918020824 NAD binding pocket [chemical binding]; other site 205918020825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918020826 catalytic loop [active] 205918020827 iron binding site [ion binding]; other site 205918020828 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 205918020829 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 205918020830 [2Fe-2S] cluster binding site [ion binding]; other site 205918020831 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 205918020832 putative alpha subunit interface [polypeptide binding]; other site 205918020833 putative active site [active] 205918020834 putative substrate binding site [chemical binding]; other site 205918020835 Fe binding site [ion binding]; other site 205918020836 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 205918020837 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 205918020838 putative active site [active] 205918020839 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205918020840 Interdomain contacts; other site 205918020841 Cytokine receptor motif; other site 205918020842 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205918020843 Interdomain contacts; other site 205918020844 Cytokine receptor motif; other site 205918020845 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 205918020846 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205918020847 Interdomain contacts; other site 205918020848 Cytokine receptor motif; other site 205918020849 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 205918020850 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 205918020851 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 205918020852 putative active site [active] 205918020853 catalytic site [active] 205918020854 1 probable transmembrane helix predicted by TMHMM2.0 205918020855 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 205918020856 Ligand Binding Site [chemical binding]; other site 205918020857 Electron transfer flavoprotein domain; Region: ETF; pfam01012 205918020858 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 205918020859 Electron transfer flavoprotein domain; Region: ETF; smart00893 205918020860 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 205918020861 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 205918020862 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 205918020863 Cysteine-rich domain; Region: CCG; pfam02754 205918020864 Cysteine-rich domain; Region: CCG; pfam02754 205918020865 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020866 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020867 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020868 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020869 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020870 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 205918020871 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 205918020872 putative active site [active] 205918020873 putative FMN binding site [chemical binding]; other site 205918020874 putative substrate binding site [chemical binding]; other site 205918020875 putative catalytic residue [active] 205918020876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205918020877 V4R domain; Region: V4R; cl15268 205918020878 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 205918020879 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 205918020880 active site 205918020881 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 205918020882 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 205918020883 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 205918020884 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 205918020885 intersubunit interface [polypeptide binding]; other site 205918020886 active site 205918020887 zinc binding site [ion binding]; other site 205918020888 Na+ binding site [ion binding]; other site 205918020889 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 205918020890 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 205918020891 Phosphoglycerate kinase; Region: PGK; pfam00162 205918020892 substrate binding site [chemical binding]; other site 205918020893 hinge regions; other site 205918020894 ADP binding site [chemical binding]; other site 205918020895 catalytic site [active] 205918020896 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 205918020897 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 205918020898 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205918020899 transketolase; Reviewed; Region: PRK12753 205918020900 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 205918020901 TPP-binding site [chemical binding]; other site 205918020902 dimer interface [polypeptide binding]; other site 205918020903 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205918020904 PYR/PP interface [polypeptide binding]; other site 205918020905 dimer interface [polypeptide binding]; other site 205918020906 TPP binding site [chemical binding]; other site 205918020907 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205918020908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918020909 putative DNA binding site [nucleotide binding]; other site 205918020910 putative Zn2+ binding site [ion binding]; other site 205918020911 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918020912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020913 S-adenosylmethionine binding site [chemical binding]; other site 205918020914 S-adenosylmethionine synthetase; Validated; Region: PRK05250 205918020915 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 205918020916 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 205918020917 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 205918020918 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 205918020919 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020920 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020921 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020922 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020923 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020924 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 205918020925 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 205918020926 nucleotide binding pocket [chemical binding]; other site 205918020927 K-X-D-G motif; other site 205918020928 catalytic site [active] 205918020929 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205918020930 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 205918020931 Predicted membrane protein [Function unknown]; Region: COG3686 205918020932 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020933 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020934 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020935 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918020936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918020937 dimerization interface [polypeptide binding]; other site 205918020938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918020939 dimer interface [polypeptide binding]; other site 205918020940 phosphorylation site [posttranslational modification] 205918020941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918020942 ATP binding site [chemical binding]; other site 205918020943 Mg2+ binding site [ion binding]; other site 205918020944 G-X-G motif; other site 205918020945 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020946 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020947 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918020948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918020949 active site 205918020950 phosphorylation site [posttranslational modification] 205918020951 intermolecular recognition site; other site 205918020952 dimerization interface [polypeptide binding]; other site 205918020953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918020954 DNA binding site [nucleotide binding] 205918020955 Outer membrane efflux protein; Region: OEP; pfam02321 205918020956 Outer membrane efflux protein; Region: OEP; pfam02321 205918020957 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 205918020958 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 205918020959 HlyD family secretion protein; Region: HlyD_3; pfam13437 205918020960 1 probable transmembrane helix predicted by TMHMM2.0 205918020961 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 205918020962 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020963 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020964 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020965 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020966 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020967 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020968 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020969 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020970 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020971 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020972 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020973 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020974 PAAR motif; Region: PAAR_motif; pfam05488 205918020975 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 205918020976 RHS Repeat; Region: RHS_repeat; pfam05593 205918020977 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020978 RHS protein; Region: RHS; pfam03527 205918020979 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020980 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020981 outer membrane porin, OprD family; Region: OprD; pfam03573 205918020982 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 205918020983 1 probable transmembrane helix predicted by TMHMM2.0 205918020984 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 205918020985 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 205918020986 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020987 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020988 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020989 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020990 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020991 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020992 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020993 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020994 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020995 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020996 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020997 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020998 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020999 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 205918021000 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 205918021001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918021002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918021003 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205918021004 sorbitol dehydrogenase; Provisional; Region: PRK07067 205918021005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918021006 NAD(P) binding site [chemical binding]; other site 205918021007 active site 205918021008 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 205918021009 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 205918021010 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 205918021011 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 205918021012 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 205918021013 G1 box; other site 205918021014 putative GEF interaction site [polypeptide binding]; other site 205918021015 GTP/Mg2+ binding site [chemical binding]; other site 205918021016 Switch I region; other site 205918021017 G2 box; other site 205918021018 G3 box; other site 205918021019 Switch II region; other site 205918021020 G4 box; other site 205918021021 G5 box; other site 205918021022 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 205918021023 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 205918021024 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 205918021025 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 205918021026 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 205918021027 Ligand Binding Site [chemical binding]; other site 205918021028 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 205918021029 glutamine synthetase; Provisional; Region: glnA; PRK09469 205918021030 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205918021031 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918021032 chorismate mutase; Provisional; Region: PRK09269 205918021033 Chorismate mutase type II; Region: CM_2; cl00693 205918021034 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918021035 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918021036 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918021037 PAS domain; Region: PAS; smart00091 205918021038 putative active site [active] 205918021039 heme pocket [chemical binding]; other site 205918021040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918021041 dimer interface [polypeptide binding]; other site 205918021042 phosphorylation site [posttranslational modification] 205918021043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918021044 ATP binding site [chemical binding]; other site 205918021045 Mg2+ binding site [ion binding]; other site 205918021046 G-X-G motif; other site 205918021047 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 205918021048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021049 active site 205918021050 phosphorylation site [posttranslational modification] 205918021051 intermolecular recognition site; other site 205918021052 dimerization interface [polypeptide binding]; other site 205918021053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918021054 Walker A motif; other site 205918021055 ATP binding site [chemical binding]; other site 205918021056 Walker B motif; other site 205918021057 arginine finger; other site 205918021058 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 205918021059 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918021060 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918021061 active site 205918021062 catalytic tetrad [active] 205918021063 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918021064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918021065 substrate binding pocket [chemical binding]; other site 205918021066 membrane-bound complex binding site; other site 205918021067 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918021068 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918021069 active site 205918021070 non-prolyl cis peptide bond; other site 205918021071 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 205918021072 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918021073 N-terminal plug; other site 205918021074 ligand-binding site [chemical binding]; other site 205918021075 BCCT family transporter; Region: BCCT; cl00569 205918021076 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021077 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021078 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021079 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021080 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021081 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021082 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021083 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021084 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021085 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021086 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021087 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021088 urocanate hydratase; Provisional; Region: PRK05414 205918021089 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 205918021090 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918021091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021092 dimer interface [polypeptide binding]; other site 205918021093 conserved gate region; other site 205918021094 putative PBP binding loops; other site 205918021095 ABC-ATPase subunit interface; other site 205918021096 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021097 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021098 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021099 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021100 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021101 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021102 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918021103 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 205918021104 Walker A/P-loop; other site 205918021105 ATP binding site [chemical binding]; other site 205918021106 Q-loop/lid; other site 205918021107 ABC transporter signature motif; other site 205918021108 Walker B; other site 205918021109 D-loop; other site 205918021110 H-loop/switch region; other site 205918021111 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 205918021112 active sites [active] 205918021113 tetramer interface [polypeptide binding]; other site 205918021114 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 205918021115 active sites [active] 205918021116 tetramer interface [polypeptide binding]; other site 205918021117 putative proline-specific permease; Provisional; Region: proY; PRK10580 205918021118 Spore germination protein; Region: Spore_permease; cl17796 205918021119 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021120 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021121 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021122 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021123 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021124 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021125 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021126 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021127 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021128 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021129 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021130 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021131 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021132 imidazolonepropionase; Validated; Region: PRK09356 205918021133 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 205918021134 active site 205918021135 N-formylglutamate amidohydrolase; Region: FGase; cl01522 205918021136 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 205918021137 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918021138 metal-binding site [ion binding] 205918021139 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918021140 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 205918021141 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021142 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021143 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021144 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021145 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021146 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 205918021147 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 205918021148 DNA binding residues [nucleotide binding] 205918021149 dimer interface [polypeptide binding]; other site 205918021150 putative metal binding site [ion binding]; other site 205918021151 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021152 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021153 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021154 thymidylate synthase; Provisional; Region: thyA; PRK13821 205918021155 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 205918021156 dimerization interface [polypeptide binding]; other site 205918021157 active site 205918021158 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 205918021159 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021160 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021161 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021162 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021163 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021164 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021165 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021166 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 205918021167 GAF domain; Region: GAF; pfam01590 205918021168 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 205918021169 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 205918021170 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 205918021171 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 205918021172 putative active site [active] 205918021173 Ap4A binding site [chemical binding]; other site 205918021174 nudix motif; other site 205918021175 putative metal binding site [ion binding]; other site 205918021176 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 205918021177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918021178 motif II; other site 205918021179 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 205918021180 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021181 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021182 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021183 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021184 threonine dehydratase; Reviewed; Region: PRK09224 205918021185 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 205918021186 tetramer interface [polypeptide binding]; other site 205918021187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918021188 catalytic residue [active] 205918021189 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 205918021190 putative Ile/Val binding site [chemical binding]; other site 205918021191 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 205918021192 putative Ile/Val binding site [chemical binding]; other site 205918021193 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 205918021194 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205918021195 active site 205918021196 dimer interface [polypeptide binding]; other site 205918021197 SdiA-regulated; Region: SdiA-regulated; pfam06977 205918021198 SdiA-regulated; Region: SdiA-regulated; cd09971 205918021199 putative active site [active] 205918021200 1 probable transmembrane helix predicted by TMHMM2.0 205918021201 SdiA-regulated; Region: SdiA-regulated; pfam06977 205918021202 SdiA-regulated; Region: SdiA-regulated; cd09971 205918021203 putative active site [active] 205918021204 1 probable transmembrane helix predicted by TMHMM2.0 205918021205 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 205918021206 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 205918021207 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 205918021208 FAD binding domain; Region: FAD_binding_4; pfam01565 205918021209 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 205918021210 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 205918021211 ligand binding site [chemical binding]; other site 205918021212 NAD binding site [chemical binding]; other site 205918021213 tetramer interface [polypeptide binding]; other site 205918021214 catalytic site [active] 205918021215 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 205918021216 L-serine binding site [chemical binding]; other site 205918021217 ACT domain interface; other site 205918021218 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 205918021219 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 205918021220 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 205918021221 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 205918021222 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021223 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021224 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 205918021225 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205918021226 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 205918021227 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918021228 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 205918021229 active site 205918021230 1 probable transmembrane helix predicted by TMHMM2.0 205918021231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918021232 Transposase; Region: HTH_Tnp_1; cl17663 205918021233 putative transposase OrfB; Reviewed; Region: PHA02517 205918021234 HTH-like domain; Region: HTH_21; pfam13276 205918021235 Integrase core domain; Region: rve; pfam00665 205918021236 Integrase core domain; Region: rve_2; pfam13333 205918021237 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918021238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021239 dimer interface [polypeptide binding]; other site 205918021240 conserved gate region; other site 205918021241 putative PBP binding loops; other site 205918021242 ABC-ATPase subunit interface; other site 205918021243 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021244 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021245 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021246 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021247 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021248 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021250 dimer interface [polypeptide binding]; other site 205918021251 conserved gate region; other site 205918021252 putative PBP binding loops; other site 205918021253 ABC-ATPase subunit interface; other site 205918021254 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021255 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021256 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021257 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021258 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021259 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021260 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 205918021261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918021262 Walker A/P-loop; other site 205918021263 ATP binding site [chemical binding]; other site 205918021264 Q-loop/lid; other site 205918021265 ABC transporter signature motif; other site 205918021266 Walker B; other site 205918021267 D-loop; other site 205918021268 H-loop/switch region; other site 205918021269 TOBE domain; Region: TOBE_2; pfam08402 205918021270 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 205918021271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205918021272 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 205918021273 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205918021274 putative aminotransferase; Validated; Region: PRK07480 205918021275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918021276 inhibitor-cofactor binding pocket; inhibition site 205918021277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918021278 catalytic residue [active] 205918021279 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205918021280 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918021281 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205918021282 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918021283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918021284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205918021285 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021286 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021287 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 205918021288 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 205918021289 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 205918021290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918021291 Walker A/P-loop; other site 205918021292 ATP binding site [chemical binding]; other site 205918021293 Q-loop/lid; other site 205918021294 ABC transporter signature motif; other site 205918021295 Walker B; other site 205918021296 D-loop; other site 205918021297 H-loop/switch region; other site 205918021298 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205918021299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021300 dimer interface [polypeptide binding]; other site 205918021301 conserved gate region; other site 205918021302 putative PBP binding loops; other site 205918021303 ABC-ATPase subunit interface; other site 205918021304 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021305 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021306 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021307 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021308 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021309 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021310 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021311 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021312 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918021313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918021314 substrate binding pocket [chemical binding]; other site 205918021315 membrane-bound complex binding site; other site 205918021316 hinge residues; other site 205918021317 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 205918021318 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 205918021319 dimer interface [polypeptide binding]; other site 205918021320 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205918021321 catalytic triad [active] 205918021322 outer membrane porin, OprD family; Region: OprD; pfam03573 205918021323 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 205918021324 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 205918021325 SecA binding site; other site 205918021326 Preprotein binding site; other site 205918021327 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 205918021328 GSH binding site [chemical binding]; other site 205918021329 catalytic residues [active] 205918021330 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 205918021331 active site residue [active] 205918021332 1 probable transmembrane helix predicted by TMHMM2.0 205918021333 phosphoglyceromutase; Provisional; Region: PRK05434 205918021334 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 205918021335 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 205918021336 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918021337 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 205918021338 C-terminal peptidase (prc); Region: prc; TIGR00225 205918021339 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 205918021340 protein binding site [polypeptide binding]; other site 205918021341 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 205918021342 Catalytic dyad [active] 205918021343 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 205918021344 NodB motif; other site 205918021345 putative active site [active] 205918021346 putative catalytic site [active] 205918021347 Zn binding site [ion binding]; other site 205918021348 Peptidase M60-like family; Region: M60-like; pfam13402 205918021349 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 205918021350 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 205918021351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918021352 substrate binding pocket [chemical binding]; other site 205918021353 membrane-bound complex binding site; other site 205918021354 hinge residues; other site 205918021355 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 205918021356 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 205918021357 substrate binding site [chemical binding]; other site 205918021358 glutamase interaction surface [polypeptide binding]; other site 205918021359 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 205918021360 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 205918021361 catalytic residues [active] 205918021362 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 205918021363 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 205918021364 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 205918021365 putative active site [active] 205918021366 oxyanion strand; other site 205918021367 catalytic triad [active] 205918021368 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 205918021369 putative active site pocket [active] 205918021370 4-fold oligomerization interface [polypeptide binding]; other site 205918021371 metal binding residues [ion binding]; metal-binding site 205918021372 3-fold/trimer interface [polypeptide binding]; other site 205918021373 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 205918021374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918021375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918021376 homodimer interface [polypeptide binding]; other site 205918021377 catalytic residue [active] 205918021378 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 205918021379 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021380 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021381 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021382 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021383 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021384 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021385 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021386 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021387 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021388 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021389 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021390 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021391 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021392 AsmA family; Region: AsmA; pfam05170 205918021393 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 205918021394 1 probable transmembrane helix predicted by TMHMM2.0 205918021395 adenine DNA glycosylase; Provisional; Region: PRK10880 205918021396 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205918021397 minor groove reading motif; other site 205918021398 helix-hairpin-helix signature motif; other site 205918021399 substrate binding pocket [chemical binding]; other site 205918021400 active site 205918021401 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 205918021402 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 205918021403 DNA binding and oxoG recognition site [nucleotide binding] 205918021404 oxidative damage protection protein; Provisional; Region: PRK05408 205918021405 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 205918021406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918021407 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 205918021408 putative active site [active] 205918021409 heme pocket [chemical binding]; other site 205918021410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918021411 putative active site [active] 205918021412 heme pocket [chemical binding]; other site 205918021413 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918021414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918021415 dimer interface [polypeptide binding]; other site 205918021416 putative CheW interface [polypeptide binding]; other site 205918021417 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 205918021418 Spore germination protein; Region: Spore_permease; cl17796 205918021419 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021420 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021421 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021422 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021423 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021424 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021425 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021426 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021427 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021428 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021429 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021430 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021431 Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA...; Region: FH; cl00061 205918021432 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 205918021433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205918021434 Walker A/P-loop; other site 205918021435 ATP binding site [chemical binding]; other site 205918021436 Q-loop/lid; other site 205918021437 ABC transporter signature motif; other site 205918021438 Walker B; other site 205918021439 D-loop; other site 205918021440 H-loop/switch region; other site 205918021441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918021442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918021443 substrate binding pocket [chemical binding]; other site 205918021444 membrane-bound complex binding site; other site 205918021445 hinge residues; other site 205918021446 1 probable transmembrane helix predicted by TMHMM2.0 205918021447 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918021448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021449 dimer interface [polypeptide binding]; other site 205918021450 conserved gate region; other site 205918021451 putative PBP binding loops; other site 205918021452 ABC-ATPase subunit interface; other site 205918021453 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021454 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021455 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021456 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021457 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021458 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918021459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021460 dimer interface [polypeptide binding]; other site 205918021461 conserved gate region; other site 205918021462 putative PBP binding loops; other site 205918021463 ABC-ATPase subunit interface; other site 205918021464 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021465 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021466 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021467 Methyltransferase domain; Region: Methyltransf_32; pfam13679 205918021468 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918021469 HSP70 interaction site [polypeptide binding]; other site 205918021470 Central core of the bacterial effector protein AvrPto; Region: AvrPto; pfam11592 205918021471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 205918021472 short chain dehydrogenase; Provisional; Region: PRK06500 205918021473 classical (c) SDRs; Region: SDR_c; cd05233 205918021474 NAD(P) binding site [chemical binding]; other site 205918021475 active site 205918021476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918021477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918021478 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918021479 putative effector binding pocket; other site 205918021480 dimerization interface [polypeptide binding]; other site 205918021481 Uncharacterized conserved protein [Function unknown]; Region: COG4748 205918021482 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 205918021483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918021484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918021485 Coenzyme A binding pocket [chemical binding]; other site 205918021486 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205918021487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918021488 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021489 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021490 outer membrane porin, OprD family; Region: OprD; pfam03573 205918021491 agmatine deiminase; Provisional; Region: PRK13551 205918021492 agmatine deiminase; Region: agmatine_aguA; TIGR03380 205918021493 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 205918021494 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 205918021495 putative active site; other site 205918021496 catalytic triad [active] 205918021497 putative dimer interface [polypeptide binding]; other site 205918021498 hypothetical protein; Provisional; Region: PRK06149 205918021499 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 205918021500 active site 205918021501 substrate binding site [chemical binding]; other site 205918021502 ATP binding site [chemical binding]; other site 205918021503 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918021504 inhibitor-cofactor binding pocket; inhibition site 205918021505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918021506 catalytic residue [active] 205918021507 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 205918021508 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 205918021509 NAD binding site [chemical binding]; other site 205918021510 substrate binding site [chemical binding]; other site 205918021511 homodimer interface [polypeptide binding]; other site 205918021512 active site 205918021513 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 205918021514 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 205918021515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918021516 dimer interface [polypeptide binding]; other site 205918021517 phosphorylation site [posttranslational modification] 205918021518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918021519 ATP binding site [chemical binding]; other site 205918021520 Mg2+ binding site [ion binding]; other site 205918021521 G-X-G motif; other site 205918021522 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021523 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021524 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918021525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021526 active site 205918021527 phosphorylation site [posttranslational modification] 205918021528 intermolecular recognition site; other site 205918021529 dimerization interface [polypeptide binding]; other site 205918021530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918021531 Walker A motif; other site 205918021532 ATP binding site [chemical binding]; other site 205918021533 Walker B motif; other site 205918021534 arginine finger; other site 205918021535 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 205918021536 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 205918021537 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 205918021538 active site 205918021539 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 205918021540 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 205918021541 dimer interface [polypeptide binding]; other site 205918021542 ADP-ribose binding site [chemical binding]; other site 205918021543 active site 205918021544 nudix motif; other site 205918021545 metal binding site [ion binding]; metal-binding site 205918021546 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 205918021547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918021548 motif II; other site 205918021549 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 205918021550 BON domain; Region: BON; pfam04972 205918021551 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918021552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918021553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918021554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918021555 dimerization interface [polypeptide binding]; other site 205918021556 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 205918021557 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 205918021558 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 205918021559 putative molybdopterin cofactor binding site [chemical binding]; other site 205918021560 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 205918021561 putative molybdopterin cofactor binding site; other site 205918021562 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 205918021563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918021564 ATP binding site [chemical binding]; other site 205918021565 putative Mg++ binding site [ion binding]; other site 205918021566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918021567 nucleotide binding region [chemical binding]; other site 205918021568 ATP-binding site [chemical binding]; other site 205918021569 1 probable transmembrane helix predicted by TMHMM2.0 205918021570 Peptidase family M48; Region: Peptidase_M48; cl12018 205918021571 Peptidase family M48; Region: Peptidase_M48; cl12018 205918021572 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021573 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021574 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021575 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021576 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021577 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021578 Protein of unknown function (DUF770); Region: DUF770; pfam05591 205918021579 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 205918021580 Protein of unknown function (DUF877); Region: DUF877; pfam05943 205918021581 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 205918021582 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 205918021583 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 205918021584 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 205918021585 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 205918021586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918021587 Walker A motif; other site 205918021588 ATP binding site [chemical binding]; other site 205918021589 Walker B motif; other site 205918021590 arginine finger; other site 205918021591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918021592 Walker A motif; other site 205918021593 ATP binding site [chemical binding]; other site 205918021594 Walker B motif; other site 205918021595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 205918021596 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 205918021597 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 205918021598 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 205918021599 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 205918021600 1 probable transmembrane helix predicted by TMHMM2.0 205918021601 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 205918021602 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 205918021603 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 205918021604 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021605 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021606 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021607 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 205918021608 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 205918021609 G1 box; other site 205918021610 GTP/Mg2+ binding site [chemical binding]; other site 205918021611 G2 box; other site 205918021612 G3 box; other site 205918021613 Switch II region; other site 205918021614 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 205918021615 G4 box; other site 205918021616 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918021617 ligand binding site [chemical binding]; other site 205918021618 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021619 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021620 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021621 Protein of unknown function (DUF796); Region: DUF796; pfam05638 205918021622 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 205918021623 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 205918021624 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 205918021625 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021626 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021627 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021628 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021629 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021630 PAAR motif; Region: PAAR_motif; pfam05488 205918021631 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918021632 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918021633 putative active site [active] 205918021634 catalytic site [active] 205918021635 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918021636 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 205918021637 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918021638 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 205918021639 putative active site [active] 205918021640 putative active site [active] 205918021641 catalytic site [active] 205918021642 catalytic site [active] 205918021643 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918021644 Sel1-like repeats; Region: SEL1; smart00671 205918021645 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918021646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 205918021647 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 205918021648 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 205918021649 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 205918021650 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 205918021651 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021652 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021653 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021654 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021655 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918021656 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 205918021657 HD domain; Region: HD_4; pfam13328 205918021658 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 205918021659 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021660 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021661 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021662 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021663 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021664 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021665 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021666 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021667 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021668 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021669 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021670 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 205918021671 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 205918021672 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 205918021673 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 205918021674 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 205918021675 PAAR motif; Region: PAAR_motif; pfam05488 205918021676 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918021677 RHS Repeat; Region: RHS_repeat; pfam05593 205918021678 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 205918021679 RHS protein; Region: RHS; pfam03527 205918021680 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021681 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021682 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021683 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 205918021684 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918021685 RHS protein; Region: RHS; pfam03527 205918021686 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021687 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918021688 RHS Repeat; Region: RHS_repeat; cl11982 205918021689 RHS Repeat; Region: RHS_repeat; cl11982 205918021690 RHS protein; Region: RHS; pfam03527 205918021691 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021692 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 205918021693 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918021694 RHS protein; Region: RHS; pfam03527 205918021695 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021696 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918021697 RHS protein; Region: RHS; pfam03527 205918021698 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918021699 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918021700 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 205918021701 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021702 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021703 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021704 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021705 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021706 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021707 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021708 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021709 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021710 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021711 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 205918021712 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021713 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021714 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918021716 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205918021717 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021718 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021719 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021720 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021721 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205918021722 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918021723 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021724 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021725 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021726 FIST N domain; Region: FIST; smart00897 205918021727 FIST C domain; Region: FIST_C; pfam10442 205918021728 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918021729 dimer interface [polypeptide binding]; other site 205918021730 putative CheW interface [polypeptide binding]; other site 205918021731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 205918021732 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 205918021733 1 probable transmembrane helix predicted by TMHMM2.0 205918021734 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 205918021735 hydrolase; Region: PLN02811 205918021736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918021737 motif II; other site 205918021738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918021739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918021740 active site 205918021741 catalytic tetrad [active] 205918021742 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 205918021743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918021744 DNA-binding site [nucleotide binding]; DNA binding site 205918021745 FCD domain; Region: FCD; pfam07729 205918021746 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 205918021747 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 205918021748 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 205918021749 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 205918021750 acyl-activating enzyme (AAE) consensus motif; other site 205918021751 AMP binding site [chemical binding]; other site 205918021752 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 205918021753 thioester reductase domain; Region: Thioester-redct; TIGR01746 205918021754 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 205918021755 putative NAD(P) binding site [chemical binding]; other site 205918021756 active site 205918021757 putative substrate binding site [chemical binding]; other site 205918021758 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 205918021759 putative hydrophobic ligand binding site [chemical binding]; other site 205918021760 protein interface [polypeptide binding]; other site 205918021761 gate; other site 205918021762 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 205918021763 CoA-transferase family III; Region: CoA_transf_3; pfam02515 205918021764 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 205918021765 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918021766 FAD binding site [chemical binding]; other site 205918021767 substrate binding pocket [chemical binding]; other site 205918021768 catalytic base [active] 205918021769 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918021770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918021771 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 205918021772 dimerization interface [polypeptide binding]; other site 205918021773 substrate binding pocket [chemical binding]; other site 205918021774 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 205918021775 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 205918021776 ligand binding site [chemical binding]; other site 205918021777 homodimer interface [polypeptide binding]; other site 205918021778 NAD(P) binding site [chemical binding]; other site 205918021779 trimer interface B [polypeptide binding]; other site 205918021780 trimer interface A [polypeptide binding]; other site 205918021781 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 205918021782 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021783 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021784 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021785 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 205918021786 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 205918021787 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021788 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021789 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021790 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021791 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021792 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021793 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021794 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021795 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 205918021796 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 205918021797 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 205918021798 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 205918021799 conserverd hypothetical protein; Region: TIGR02448 205918021800 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 205918021801 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 205918021802 Cell division protein FtsL; Region: FtsL; cl11433 205918021803 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918021804 IHF dimer interface [polypeptide binding]; other site 205918021805 IHF - DNA interface [nucleotide binding]; other site 205918021806 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 205918021807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918021808 Rubredoxin [Energy production and conversion]; Region: COG1773 205918021809 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 205918021810 iron binding site [ion binding]; other site 205918021811 Chorismate lyase; Region: Chor_lyase; cl01230 205918021812 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 205918021813 UbiA prenyltransferase family; Region: UbiA; pfam01040 205918021814 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021815 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021816 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021817 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021818 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021819 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021820 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021821 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 205918021822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021823 active site 205918021824 phosphorylation site [posttranslational modification] 205918021825 intermolecular recognition site; other site 205918021826 dimerization interface [polypeptide binding]; other site 205918021827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918021828 DNA binding site [nucleotide binding] 205918021829 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 205918021830 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205918021831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918021832 putative active site [active] 205918021833 heme pocket [chemical binding]; other site 205918021834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918021835 dimer interface [polypeptide binding]; other site 205918021836 phosphorylation site [posttranslational modification] 205918021837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918021838 ATP binding site [chemical binding]; other site 205918021839 Mg2+ binding site [ion binding]; other site 205918021840 G-X-G motif; other site 205918021841 1 probable transmembrane helix predicted by TMHMM2.0 205918021842 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 205918021843 Domain of unknown function DUF21; Region: DUF21; pfam01595 205918021844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918021845 Transporter associated domain; Region: CorC_HlyC; smart01091 205918021846 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021847 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021848 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021849 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021850 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918021851 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 205918021852 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918021853 Response regulator receiver domain; Region: Response_reg; pfam00072 205918021854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021855 active site 205918021856 phosphorylation site [posttranslational modification] 205918021857 intermolecular recognition site; other site 205918021858 dimerization interface [polypeptide binding]; other site 205918021859 transcriptional regulator PhoU; Provisional; Region: PRK11115 205918021860 PhoU domain; Region: PhoU; pfam01895 205918021861 PhoU domain; Region: PhoU; pfam01895 205918021862 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 205918021863 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 205918021864 Walker A/P-loop; other site 205918021865 ATP binding site [chemical binding]; other site 205918021866 Q-loop/lid; other site 205918021867 ABC transporter signature motif; other site 205918021868 Walker B; other site 205918021869 D-loop; other site 205918021870 H-loop/switch region; other site 205918021871 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 205918021872 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 205918021873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021874 dimer interface [polypeptide binding]; other site 205918021875 conserved gate region; other site 205918021876 putative PBP binding loops; other site 205918021877 ABC-ATPase subunit interface; other site 205918021878 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021879 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021880 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021881 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021882 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021883 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021884 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 205918021885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021886 dimer interface [polypeptide binding]; other site 205918021887 conserved gate region; other site 205918021888 putative PBP binding loops; other site 205918021889 ABC-ATPase subunit interface; other site 205918021890 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021891 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021892 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021893 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021894 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021895 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021896 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021897 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021898 PBP superfamily domain; Region: PBP_like_2; cl17296 205918021899 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918021900 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918021901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918021902 putative substrate translocation pore; other site 205918021903 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021904 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021905 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021906 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021907 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021908 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021909 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021910 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021911 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021912 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021913 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021914 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021915 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 205918021916 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 205918021917 active site 205918021918 phosphate binding residues; other site 205918021919 catalytic residues [active] 205918021920 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 205918021921 Predicted membrane protein [Function unknown]; Region: COG2261 205918021922 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021923 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021924 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021925 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 205918021926 ATP-grasp domain; Region: ATP-grasp; pfam02222 205918021927 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 205918021928 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 205918021929 1 probable transmembrane helix predicted by TMHMM2.0 205918021930 cell density-dependent motility repressor; Provisional; Region: PRK10082 205918021931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918021932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918021933 dimerization interface [polypeptide binding]; other site 205918021934 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 205918021935 Aspartase; Region: Aspartase; cd01357 205918021936 active sites [active] 205918021937 tetramer interface [polypeptide binding]; other site 205918021938 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 205918021939 amino acid carrier protein; Region: agcS; TIGR00835 205918021940 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021941 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021942 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021943 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021944 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021945 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021946 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021947 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021948 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021949 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021950 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 205918021951 active site 205918021952 homodimer interface [polypeptide binding]; other site 205918021953 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 205918021954 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021955 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021956 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021957 Sulphur transport; Region: Sulf_transp; pfam04143 205918021958 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021959 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021960 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021961 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021962 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021963 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021964 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021965 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021966 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021967 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021968 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021969 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918021970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918021971 DNA-binding site [nucleotide binding]; DNA binding site 205918021972 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918021973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918021974 homodimer interface [polypeptide binding]; other site 205918021975 catalytic residue [active] 205918021976 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 205918021977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918021978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918021979 Coenzyme A binding pocket [chemical binding]; other site 205918021980 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205918021981 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205918021982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205918021983 pyruvate carboxylase subunit B; Validated; Region: PRK09282 205918021984 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 205918021985 active site 205918021986 catalytic residues [active] 205918021987 metal binding site [ion binding]; metal-binding site 205918021988 homodimer binding site [polypeptide binding]; other site 205918021989 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918021990 carboxyltransferase (CT) interaction site; other site 205918021991 biotinylation site [posttranslational modification]; other site 205918021992 pyruvate carboxylase subunit A; Validated; Region: PRK07178 205918021993 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918021994 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 205918021995 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 205918021996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918021997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205918021998 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 205918021999 putative dimerization interface [polypeptide binding]; other site 205918022000 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 205918022001 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205918022002 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918022003 putative active site [active] 205918022004 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 205918022005 Part of AAA domain; Region: AAA_19; pfam13245 205918022006 Family description; Region: UvrD_C_2; pfam13538 205918022007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 205918022008 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022009 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022010 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 205918022011 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 205918022012 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 205918022013 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022014 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022015 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022016 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022017 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022018 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022019 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022020 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022021 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022022 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022023 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022024 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022025 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022026 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022027 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918022028 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 205918022029 pyridoxamine kinase; Validated; Region: PRK05756 205918022030 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 205918022031 pyridoxal binding site [chemical binding]; other site 205918022032 dimer interface [polypeptide binding]; other site 205918022033 ATP binding site [chemical binding]; other site 205918022034 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 205918022035 1 probable transmembrane helix predicted by TMHMM2.0 205918022036 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 205918022037 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 205918022038 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 205918022039 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 205918022040 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 205918022041 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 205918022042 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 205918022043 AMIN domain; Region: AMIN; pfam11741 205918022044 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 205918022045 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 205918022046 active site 205918022047 metal binding site [ion binding]; metal-binding site 205918022048 1 probable transmembrane helix predicted by TMHMM2.0 205918022049 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 205918022050 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 205918022051 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 205918022052 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 205918022053 putative active site [active] 205918022054 catalytic site [active] 205918022055 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918022056 putative active site [active] 205918022057 catalytic site [active] 205918022058 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022059 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022060 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 205918022061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918022062 S-adenosylmethionine binding site [chemical binding]; other site 205918022063 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 205918022064 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918022065 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022066 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022067 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022068 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022069 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022070 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022071 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022072 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205918022073 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 205918022074 1 probable transmembrane helix predicted by TMHMM2.0 205918022075 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 205918022076 HflC protein; Region: hflC; TIGR01932 205918022077 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205918022078 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 205918022079 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022080 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022081 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022082 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022083 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022084 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022085 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918022086 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 205918022087 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 205918022088 1 probable transmembrane helix predicted by TMHMM2.0 205918022089 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022090 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022091 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022092 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022093 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022094 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022095 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022096 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022097 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022098 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022099 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918022100 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205918022101 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022102 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022103 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022104 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022105 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022106 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022107 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022108 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022109 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022110 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 205918022111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918022112 active site 205918022113 phosphorylation site [posttranslational modification] 205918022114 intermolecular recognition site; other site 205918022115 dimerization interface [polypeptide binding]; other site 205918022116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918022117 dimerization interface [polypeptide binding]; other site 205918022118 DNA binding residues [nucleotide binding] 205918022119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918022120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918022121 dimer interface [polypeptide binding]; other site 205918022122 phosphorylation site [posttranslational modification] 205918022123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918022124 ATP binding site [chemical binding]; other site 205918022125 Mg2+ binding site [ion binding]; other site 205918022126 G-X-G motif; other site 205918022127 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918022128 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918022129 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918022130 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918022131 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 205918022132 Walker A/P-loop; other site 205918022133 ATP binding site [chemical binding]; other site 205918022134 Q-loop/lid; other site 205918022135 ABC transporter signature motif; other site 205918022136 Walker B; other site 205918022137 D-loop; other site 205918022138 H-loop/switch region; other site 205918022139 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 205918022140 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 205918022141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918022142 dimer interface [polypeptide binding]; other site 205918022143 conserved gate region; other site 205918022144 putative PBP binding loops; other site 205918022145 ABC-ATPase subunit interface; other site 205918022146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918022147 dimer interface [polypeptide binding]; other site 205918022148 conserved gate region; other site 205918022149 putative PBP binding loops; other site 205918022150 ABC-ATPase subunit interface; other site 205918022151 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022152 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022153 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022154 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022155 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022156 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022157 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022158 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022159 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022160 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022161 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022162 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022163 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918022164 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918022165 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918022166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918022167 dimerization interface [polypeptide binding]; other site 205918022168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918022169 dimer interface [polypeptide binding]; other site 205918022170 putative CheW interface [polypeptide binding]; other site 205918022171 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022172 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022173 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918022174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918022175 dimerization interface [polypeptide binding]; other site 205918022176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918022177 dimer interface [polypeptide binding]; other site 205918022178 putative CheW interface [polypeptide binding]; other site 205918022179 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022180 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022181 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 205918022182 dimanganese center [ion binding]; other site 205918022183 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 205918022184 dimerization interface [polypeptide binding]; other site 205918022185 metal binding site [ion binding]; metal-binding site 205918022186 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 205918022187 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 205918022188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918022189 S-adenosylmethionine binding site [chemical binding]; other site 205918022190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918022191 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 205918022192 putative metal binding site [ion binding]; other site 205918022193 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205918022194 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918022195 Walker A/P-loop; other site 205918022196 ATP binding site [chemical binding]; other site 205918022197 Q-loop/lid; other site 205918022198 ABC transporter signature motif; other site 205918022199 Walker B; other site 205918022200 D-loop; other site 205918022201 H-loop/switch region; other site 205918022202 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 205918022203 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 205918022204 putative ligand binding residues [chemical binding]; other site 205918022205 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 205918022206 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918022207 ABC-ATPase subunit interface; other site 205918022208 dimer interface [polypeptide binding]; other site 205918022209 putative PBP binding regions; other site 205918022210 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022211 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022212 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022213 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022214 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022215 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022216 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022217 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022218 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022219 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 205918022220 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 205918022221 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 205918022222 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 205918022223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918022224 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 205918022225 putative NAD(P) binding site [chemical binding]; other site 205918022226 active site 205918022227 putative substrate binding site [chemical binding]; other site 205918022228 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 205918022229 Ligand binding site; other site 205918022230 Putative Catalytic site; other site 205918022231 DXD motif; other site 205918022232 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 205918022233 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022234 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022235 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 205918022236 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 205918022237 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022238 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022239 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022240 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022241 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022242 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022243 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022244 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022245 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918022246 SdiA-regulated; Region: SdiA-regulated; pfam06977 205918022247 SdiA-regulated; Region: SdiA-regulated; cd09971 205918022248 putative active site [active] 205918022249 1 probable transmembrane helix predicted by TMHMM2.0 205918022250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918022251 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 205918022252 NAD(P) binding site [chemical binding]; other site 205918022253 active site 205918022254 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 205918022255 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918022256 tetramer interface [polypeptide binding]; other site 205918022257 active site 205918022258 Mg2+/Mn2+ binding site [ion binding]; other site 205918022259 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918022260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918022261 ATP binding site [chemical binding]; other site 205918022262 putative Mg++ binding site [ion binding]; other site 205918022263 helicase superfamily c-terminal domain; Region: HELICc; smart00490 205918022264 nucleotide binding region [chemical binding]; other site 205918022265 ATP-binding site [chemical binding]; other site 205918022266 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 205918022267 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 205918022268 glutaminase active site [active] 205918022269 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 205918022270 dimer interface [polypeptide binding]; other site 205918022271 active site 205918022272 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 205918022273 dimer interface [polypeptide binding]; other site 205918022274 active site 205918022275 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 205918022276 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 205918022277 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 205918022278 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 205918022279 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 205918022280 Substrate binding site; other site 205918022281 Mg++ binding site; other site 205918022282 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 205918022283 active site 205918022284 substrate binding site [chemical binding]; other site 205918022285 CoA binding site [chemical binding]; other site 205918022286 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 205918022287 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 205918022288 gamma subunit interface [polypeptide binding]; other site 205918022289 epsilon subunit interface [polypeptide binding]; other site 205918022290 LBP interface [polypeptide binding]; other site 205918022291 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 205918022292 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205918022293 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 205918022294 alpha subunit interaction interface [polypeptide binding]; other site 205918022295 Walker A motif; other site 205918022296 ATP binding site [chemical binding]; other site 205918022297 Walker B motif; other site 205918022298 inhibitor binding site; inhibition site 205918022299 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205918022300 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 205918022301 core domain interface [polypeptide binding]; other site 205918022302 delta subunit interface [polypeptide binding]; other site 205918022303 epsilon subunit interface [polypeptide binding]; other site 205918022304 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 205918022305 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205918022306 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 205918022307 beta subunit interaction interface [polypeptide binding]; other site 205918022308 Walker A motif; other site 205918022309 ATP binding site [chemical binding]; other site 205918022310 Walker B motif; other site 205918022311 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205918022312 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 205918022313 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 205918022314 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 205918022315 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 205918022316 1 probable transmembrane helix predicted by TMHMM2.0 205918022317 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 205918022318 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022319 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918022320 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 205918022321 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 205918022322 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918022323 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918022324 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918022325 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918022326 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918022327 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918022328 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 205918022329 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022330 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022331 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022332 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022333 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 205918022334 ParB-like nuclease domain; Region: ParBc; pfam02195 205918022335 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918022336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 205918022337 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918022338 Magnesium ion binding site [ion binding]; other site 205918022339 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 205918022340 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 205918022341 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 205918022342 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 205918022343 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 205918022344 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 205918022345 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 205918022346 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 205918022347 trmE is a tRNA modification GTPase; Region: trmE; cd04164 205918022348 G1 box; other site 205918022349 GTP/Mg2+ binding site [chemical binding]; other site 205918022350 Switch I region; other site 205918022351 G2 box; other site 205918022352 Switch II region; other site 205918022353 G3 box; other site 205918022354 G4 box; other site 205918022355 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 205918022356 membrane protein insertase; Provisional; Region: PRK01318 205918022357 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 205918022358 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022359 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022360 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022361 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918022362 hypothetical protein; Provisional; Region: PRK14371 205918022363 ribonuclease P; Reviewed; Region: rnpA; PRK00396 205918022364 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399